CN114047557B

CN114047557B - Test tube detection method and sample transmission device

Info

Publication number: CN114047557B
Application number: CN202111237434.XA
Authority: CN
Inventors: 唐勇; 周涌; 钱大兴; 强军奇
Original assignee: Maccura Medical Electronics Co Ltd
Current assignee: Maccura Medical Electronics Co Ltd
Priority date: 2021-10-22
Filing date: 2021-10-22
Publication date: 2023-11-14
Anticipated expiration: 2041-10-22
Also published as: CN114047557A

Abstract

The embodiment of the application discloses a test tube detection method and a sample transmission device, wherein the test tube detection method can comprise the following steps: firstly, determining first movement information of a starting position of the test tube rack relative to a sample injection area of the test tube rack when a first position point in a first cavity of the test tube rack reaches a detection position, and second movement information of the test tube rack relative to the starting position when a second position point in the first cavity reaches the detection position; then, acquiring first signal intensity of a photoelectric signal between the first movement information and the second movement information, wherein the photoelectric signal is obtained through a first photoelectric sensor; and finally, determining the test tube condition corresponding to the first cavity according to the first signal intensity. By implementing the method, the condition of the test tube in the cavity can be identified efficiently with lower power consumption.

Description

Test tube detection method and sample transmission device

Technical Field

The application relates to the technical field of medical instruments, in particular to a test tube detection method and a sample transmission device.

Background

Existing test tube assays are generally classified into contact test tube assays and non-contact test tube assays. Among them, the contact tube test generally has a problem of sample fluid overflowing due to pressure generated by contact, and the non-contact tube test is widely used because it does not have the problem.

In practice, the existing non-contact test tube detection is mostly realized by an ultrasonic sensor, and the power consumption of the ultrasonic sensor is relatively high during working, so that how to realize the non-contact test tube detection with relatively low power consumption becomes a technical problem to be solved in industry.

Disclosure of Invention

The embodiment of the application provides a test tube detection method and a sample transmission device, which can efficiently identify the condition of a test tube in a cavity with lower power consumption.

The first aspect of the embodiment of the application discloses a test tube detection method, which comprises the following steps:

determining first movement information of a starting position of the test tube rack relative to a sample injection area of the test tube rack when a first position point in a first cavity of the test tube rack reaches a detection position, and second movement information of the test tube rack relative to the starting position when a second position point in the first cavity reaches the detection position; the first cavity is any one of a plurality of cavities on the test tube rack, a distance value between the first position point and the first side edge of the first cavity is a first distance value, and a distance value between the second position point and the first side edge of the first cavity is a second distance value;

Acquiring first signal intensity of photoelectric signals between the first movement information and the second movement information; wherein the photoelectric signal is obtained through a first photoelectric sensor;

and determining the test tube condition corresponding to the first cavity according to the first signal intensity.

As an optional implementation manner, in the first aspect of the embodiment of the present application, the first photoelectric sensor includes a first photoelectric receiver, and the acquiring a first signal strength of a photoelectric signal between the first movement information and the second movement information includes:

and acquiring first signal intensity of the photoelectric signal between the first movement information and the second movement information from the photoelectric signal acquired by the first photoelectric receiver in the movement process of the test tube rack.

and acquiring first signal intensity of photoelectric signals between the first movement information and the second movement information through the first photoelectric receiver in the movement process of the test tube rack.

In a first aspect of the embodiment of the present application, the determining, according to the first signal strength, a test tube condition corresponding to the first cavity includes:

determining that no cuvette is present in the first cavity when the first signal intensity is in a target intensity interval;

and determining that a test tube exists in the first cavity when the first signal intensity is smaller than the lower limit intensity of the target intensity interval.

As an optional implementation manner, in the first aspect of the embodiment of the present application, when the first signal intensity is less than the lower limit intensity of the target intensity interval, determining that the test tube exists in the first cavity includes:

when the first signal intensity is smaller than the lower limit intensity of the target intensity interval, calculating a first intensity difference value between the maximum first signal intensity and the lower limit intensity;

when the first intensity difference value is larger than a first difference value threshold value, determining that a test tube with a preset height is reached by the sample liquid in the first cavity;

and when the first intensity difference value is smaller than or equal to the first difference value threshold value, determining that a test tube with the sample liquid not reaching the preset height exists in the first cavity.

As an optional implementation manner, in a first aspect of the embodiment of the present application, the first photoelectric sensor includes a first photoelectric receiver and a first photoelectric transmitter, and before determining, according to the first signal strength, a test tube situation corresponding to the first cavity, the method further includes:

before the test tube rack does not move, if the second signal intensity of the photoelectric signal received by the first photoelectric receiver is a first intensity threshold value, a first duty ratio corresponding to a first photoelectric transmitter is obtained;

controlling the first photoelectric transmitter to work at half of the first duty cycle, and acquiring third signal intensity of a photoelectric signal received by the first photoelectric receiver;

and determining the target intensity interval according to the third signal intensity under the condition that the third signal intensity is more than half of the first intensity threshold.

As an optional implementation manner, in the first aspect of the embodiment of the present application, when determining that the first position point in the first cavity of the test tube rack is at the detection position, first movement information of the starting position of the test tube rack relative to the sample injection area of the test tube rack, and when determining that the second position point in the first cavity is at the detection position, second movement information of the test tube rack relative to the starting position includes:

After the standard distance of the test tube rack relative to the initial position is determined, when the first side edge of the test tube rack reaches the detection position, third movement information of the test tube rack relative to the initial position is obtained; the first side edge of the test tube rack is a side far away from the initial position;

and obtaining first movement information of the initial position of the test tube rack relative to the sample injection area of the test tube rack when a first position point in a first cavity of the test tube rack reaches a detection position and second movement information of the test tube rack relative to the initial position when a second position point in the first cavity reaches the detection position according to the third movement information, the parameters of the test tube rack, the first distance value and the second distance value.

As an optional implementation manner, in the first aspect of the embodiment of the present application, the first side edge of the first cavity is a side of the first cavity away from the starting position, the first cavity is an adjacent cavity of the first side edge of the test tube rack, and the parameter of the test tube rack includes a distance value between the first side edge of the test tube rack and the first side edge of the first cavity;

The step of obtaining the first movement information of the initial position of the test tube rack relative to the sample injection area of the test tube rack when the first position point in the first cavity of the test tube rack reaches the detection position and the second movement information of the test tube rack relative to the initial position when the second position point in the first cavity reaches the detection position according to the third movement information, the parameters of the test tube rack, the first distance value and the second distance value, comprises the following steps:

obtaining first movement information of the initial position of the test tube rack relative to the sample injection area of the test tube rack when a first position point in a first cavity of the test tube rack reaches a detection position by using the distance value included in the third movement information and the interval distance value and the first distance value;

and obtaining second movement information of the test tube rack relative to the initial position when the second position point in the first cavity reaches the detection position by utilizing the distance value included in the third movement information and the interval distance value and the second distance value.

In an optional implementation manner, in a first aspect of the embodiment of the present application, the first side edge of the first cavity is a side away from the starting position, the first distance value and the second distance value are both smaller than a radius of the first cavity, and the first distance value is smaller than the second distance value.

As an alternative implementation manner, in the first aspect of the embodiment of the present application, the first distance value is 1/7 of a diameter of the first cavity, and the second distance value is 1/3 of the diameter of the first cavity.

A second aspect of an embodiment of the present application discloses a sample transmission device, including:

the test tube rack detection device comprises a determination unit, a detection unit and a control unit, wherein the determination unit is used for determining first movement information of a starting position of the test tube rack relative to a sample injection area of the test tube rack when a first position point in a first cavity of the test tube rack reaches a detection position, and second movement information of the test tube rack relative to the starting position when a second position point in the first cavity reaches the detection position; the first cavity is any one of a plurality of cavities on the test tube rack, a distance value between the first position point and the first side edge of the first cavity is a first distance value, a distance value between the second position point and the first side edge of the first cavity is a second distance value, the first side edge of the first cavity is one side, away from the initial position, of the first cavity, and the first distance value is smaller than the second distance value;

an acquisition unit configured to acquire a first signal strength of an optoelectronic signal between the first movement information and the second movement information; wherein the photoelectric signal is obtained through a first photoelectric sensor;

And the analysis unit is used for determining the test tube condition corresponding to the first cavity according to the first signal intensity.

A third aspect of an embodiment of the present application discloses a sample transmission device, including:

a memory storing executable program code;

and a processor coupled to the memory;

the processor invokes the executable program code stored in the memory, which when executed by the processor causes the processor to implement the method of the first aspect.

A fourth aspect of the embodiments of the present application discloses a computer readable storage medium having stored thereon executable program code which, when executed by a processor, implements the method according to the first aspect.

A fifth aspect of an embodiment of the application discloses a computer program product which, when run on a computer, causes the computer to perform the method according to the first aspect of the embodiment of the application.

A sixth aspect of the embodiments of the present application discloses an application publishing platform for publishing a computer program product, wherein the computer program product, when run on a computer, causes the computer to perform the method according to the first aspect of the embodiments of the present application.

From the above technical solutions, the embodiment of the present application has the following advantages:

the test tube detection method disclosed by the embodiment of the application can comprise the following steps: firstly, determining first movement information of a starting position of the test tube rack relative to a sample injection area of the test tube rack when a first position point in a first cavity of the test tube rack reaches a detection position, and second movement information of the test tube rack relative to the starting position when a second position point in the first cavity reaches the detection position; then, acquiring first signal intensity of a photoelectric signal between the first movement information and the second movement information, wherein the photoelectric signal is obtained through a first photoelectric sensor; and finally, determining the test tube condition corresponding to the first cavity according to the first signal intensity. By implementing the method, on one hand, the power consumption of the photoelectric sensor in operation is far smaller than that of the ultrasonic sensor, so that the power consumption of equipment can be greatly reduced by performing test tube detection based on the photoelectric sensor. On the other hand, according to any cavity on the test tube rack, the test tube condition corresponding to the cavity can be determined rapidly according to the signal intensity of the photoelectric signal between the first movement information and the second movement information. In conclusion, the condition of the test tube in the cavity can be identified efficiently with lower power consumption.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings used in the description of the embodiments and the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings.

FIG. 1 is a schematic illustration of a scenario disclosed in an embodiment of the present application;

FIG. 2A is a schematic flow chart of a test tube detection method according to an embodiment of the present application;

FIG. 2B is a schematic diagram of a signal sampling curve disclosed in an embodiment of the present application;

FIG. 3A is a flow chart of another test tube detection method disclosed in an embodiment of the present application;

fig. 3B is a diagram of the interval area of the test tube rack 102 disclosed in the embodiment of the present application;

FIG. 3C is a graphical representation of a first correspondence;

FIG. 3D is a diagram of a second correspondence disclosed in an embodiment of the present application;

fig. 4 is a block diagram of a sample transmission apparatus according to an embodiment of the present application;

fig. 5 is a block diagram of a sample transmission apparatus according to an embodiment of the present application.

Detailed Description

In order that those skilled in the art will better understand the present application, reference will now be made to the accompanying drawings in which embodiments of the application are illustrated, it being apparent that the embodiments described are only some, but not all, of the embodiments of the application. Based on the embodiments of the present application, it should be understood that the present application is within the scope of protection.

It should be noted that the terms "comprising" and "having" and any variations thereof in the embodiments of the present application and the accompanying drawings are intended to cover non-exclusive inclusions. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those listed steps or elements but may include other steps or elements not listed or inherent to such process, method, article, or apparatus.

It will be understood that the terms first, second, etc. as used herein may be used to describe various elements, but these elements are not limited by these terms. These terms are only used to distinguish one element from another element. For example, the first movement information may be referred to as second movement information, and similarly, the second movement information may be referred to as first movement information, without departing from the scope of the present application. Both the first movement information and the second movement information are movement information, but they are not the same movement information. In addition, the term "plurality" as used in the embodiments of the present application refers to two or more.

The technical scheme of the application is further described below by way of examples.

Referring to fig. 1, fig. 1 is a schematic diagram of a scenario disclosed in an embodiment of the present application, where the scenario includes a sample transmission device 10, a sample injection area 101 of a test tube rack arranged on the sample transmission device 10, a test tube rack 102, a first photoelectric sensor 103 and a second photoelectric sensor 104. The second photoelectric sensor 104 is disposed at a start position of the sample injection area 101 of the test tube rack, and is configured to detect a homing condition of the test tube rack 102, i.e. whether a start moving position of the test tube rack is the start position of the sample injection area of the test tube rack. It should be noted that, the test tube rack 102 includes a plurality of cavities for placing test tubes; the first photosensor 103 includes a first photoemitter 1031 and a first photoreceiver 1032. Alternatively, the first photo-emitter 1031 may emit infrared rays or visible rays, which are not limited in the embodiment of the present application.

The signal intensities mentioned in the embodiments of the present application (including the first signal intensity, the second signal intensity, the third signal intensity, and the fourth signal intensity in the embodiments described below) may be represented by an AD value, where the AD value is used to represent the signal intensity when the photoelectric signal is converted into a digital signal.

The sample transmission device disclosed by the embodiment of the application can further comprise a motor for driving the test tube rack to move, wherein the movement information (including the first movement information, the second movement information, the third movement information, the fourth movement information, the fifth movement information, the sixth movement information and the seventh movement information) of the test tube rack relative to the initial position of the test tube sample injection area can be obtained through the motor. The movement information of the initial position of the test tube rack relative to the test tube sample injection area can be represented by a movement distance value; or if the motor is a stepping motor, the movement information of the initial position of the test tube rack relative to the test tube sample injection area can be represented by the step number of the motor, and the embodiment of the application is not limited.

Referring to fig. 2A, fig. 2A is a schematic flow chart of a test tube detection method according to an embodiment of the present application, and the test tube detection method shown in fig. 2 is suitable for the sample transmission device 10 shown in fig. 1, and may include the following steps:

201. when a first position point in a first cavity of the test tube rack is determined to be at a detection position, first movement information of the test tube rack relative to the initial position of the sample injection area of the test tube rack, and when a second position point in the first cavity is determined to be at the detection position, second movement information of the test tube rack relative to the initial position are determined.

The detection position may be indicated by a detection position corresponding to the first photoelectric sensor. The first cavity is any one of a plurality of cavities on the test tube rack, the distance value between the first position point and the first side edge of the first cavity is a first distance value, and the distance value between the second position point and the first side edge of the first cavity is a second distance value.

The edge of the first side of the first cavity may be a side of the first cavity away from the initial position, or a side of the first cavity close to the initial position, which is not limited in the embodiment of the present application.

Referring to fig. 2B, fig. 2B is a schematic diagram of a signal sampling curve according to an embodiment of the present application, and fig. 2B includes a signal sampling curve 20 in the case of empty pipe, a sampling curve 30 in the case of no pipe, and a sampling curve 40 in the case of full test tube with a sample liquid. As shown in fig. 2B, there is a distinct test tube-free section at the front end and the rear end of the cavity, where if the first side edge is the side of the first cavity away from the starting position, the front end section of the cavity may be the section that can be irradiated by the first photo-emitter and is close to the first side edge of the cavity, and the rear end section of the cavity may be the section that can be irradiated by the first photo-emitter and is far away from the first side edge of the cavity. The section lengths of the front section and the rear section of the cavity are shown in fig. 2B.

The signal sampling curve shown in fig. 2B is exemplified by a cylindrical test tube, and when the test tube is filled with a sample liquid (i.e., the height of the sample liquid in the test tube reaches a preset height), the photoelectric signals emitted by the first photoelectric emitter are all collected at the middle part of the test tube when the front end section and the rear end section of each cavity reach the detection position, so that the signal intensity received by the first photoelectric receiver is close to 0 when the front end section and the rear end section are formed. When the height of the sample liquid in the test tube does not reach the preset height (including empty tube condition), the photoelectric signal emitted by the first photoelectric emitter generates light scattering in the test tube, so that the signal intensity received by the first photoelectric receiver in the front end section and the rear end section is smaller than that received by the first photoelectric receiver in the front end section and the rear end section in the absence of the test tube.

In the following, the front end section of the cavity is taken as an example, and in different situations, the signal intensities of the signals collected in the front end section of the cavity are obviously different, so that the test tube condition corresponding to the cavity can be rapidly identified based on the signal intensity corresponding to the front end section of the cavity. The rear end section of the cavity is the same.

It may be appreciated that the first location point and the second location point may both be located in a front end section of the first cavity, or the first location point and the second location point may both be located in a rear end section of the first cavity, which is not limited by the embodiment of the present application. The edge of the first side of the first cavity may be a side of the first cavity away from the initial position or a side of the first cavity close to the initial position, which is not limited in the embodiment of the present application.

In some embodiments, the first position point and the second position point are both located in the front end section of the first cavity, which is beneficial to further improving the detection efficiency of the test tube. At this time, if the first side edge is a side of the first cavity away from the starting position, both the first distance value and the second distance value are smaller than the radius of the first cavity, and the first distance value is smaller than the second distance value. Similarly, if the edge of the first side is the side of the first cavity close to the initial position, the first distance value and the second distance value are both greater than the radius of the first cavity, and the first distance value is greater than the second distance value.

Further, in some embodiments, if the first location point and the second location point are located in a front end section of the first cavity, and the first side edge is a side of the first cavity away from the starting location, the first distance value is 1/7 of a diameter of the first cavity, and the second distance value is 1/3 of the diameter of the first cavity.

202. A first signal strength of an optoelectronic signal between the first movement information and the second movement information is acquired.

It is understood that the photoelectric signal between the first movement information and the second movement information is a photoelectric signal received by the first photoelectric receiver when the front end region of the first cavity reaches the detection position, or a photoelectric signal received by the first photoelectric receiver when the rear end region of the first cavity reaches the detection position.

In some embodiments, obtaining a first signal strength of the optoelectronic signal between the first movement information and the second movement information may include, but is not limited to, the following:

mode 1, a first signal intensity of a photoelectric signal between first movement information and second movement information is obtained from a photoelectric signal acquired by a first photoelectric receiver of a test tube rack in a movement process.

In some embodiments, in the process of moving the test tube rack relative to the initial position, a correspondence table may be obtained through the first photoelectric receiver, and further, from the correspondence table, a first signal intensity of the photoelectric signal between the first movement information and the second movement information is searched. The correspondence table may include a plurality of first signal strengths and movement information corresponding to each first signal strength. It can be understood that in the moving process of the initial position of the test tube rack relative to the test tube sample injection area, the moving information can be periodically collected, so as to obtain the intensity of the photoelectric signal received by the first photoelectric receiver corresponding to the moving information.

Mode 2, test-tube rack is in the removal in-process, gathers the first signal strength of the photoelectric signal that is in between first removal information and the second removal information through first photoelectric receiver.

It can be understood that when the test tube rack moves the first movement information relative to the initial position, the first photoelectric receiver starts to receive the photoelectric signal transmitted by the first photoelectric transmitter, so as to detect the intensity of the photoelectric signal received by the first photoelectric receiver, and when the test tube rack moves the second movement information relative to the initial position, the first photoelectric receiver stops receiving the photoelectric signal transmitted by the first photoelectric transmitter, so as to stop detecting the intensity of the photoelectric signal received by the first photoelectric receiver. By implementing the method, the first photoelectric transmitter and the first photoelectric receiver do not need to be in a working state continuously, and the power consumption of the equipment is reduced.

203. And determining the test tube condition corresponding to the first cavity according to the first signal intensity.

The test tube condition corresponding to the first cavity can include that no test tube exists in the first cavity, that the sample liquid does not reach the preset height exists in the first cavity, and that the sample liquid reaches the preset height exists in the first cavity.

In some embodiments, determining, based on the first signal strength, a cuvette condition corresponding to the first cavity includes: and determining the test tube condition corresponding to the first cavity according to the first signal intensity and the target intensity interval. It should be noted that the target intensity interval may be obtained through multiple experiments.

By implementing the method, on one hand, the power consumption of the photoelectric sensor in operation is far smaller than that of the ultrasonic sensor, so that the power consumption of equipment can be greatly reduced by performing test tube detection based on the photoelectric sensor. On the other hand, according to any cavity on the test tube rack, the test tube condition corresponding to the cavity can be determined rapidly according to the signal intensity of the photoelectric signal between the first movement information and the second movement information. In conclusion, the condition of the test tube in the cavity can be identified efficiently with lower power consumption.

Referring to fig. 3A, fig. 3A is a flowchart illustrating another test tube testing method according to an embodiment of the present application, and the test tube testing method shown in fig. 3A is suitable for the sample transmission device 10 shown in fig. 1, and may include the following steps:

301. when a first position point in a first cavity of the test tube rack is determined to be at a detection position, first movement information of the test tube rack relative to the initial position of the sample injection area of the test tube rack, and when a second position point in the first cavity is determined to be at the detection position, second movement information of the test tube rack relative to the initial position are determined.

In some embodiments, when determining that the first position point in the first cavity of the test tube rack is at the detection position, the first movement information of the starting position of the test tube rack relative to the sample injection area of the test tube rack, and when determining that the second position point in the first cavity is at the detection position, the second movement information of the test tube rack relative to the starting position may include:

after the standard distance of the test tube rack relative to the initial position is determined, when the first side edge of the test tube rack reaches the detection position, third movement information of the test tube rack relative to the initial position is obtained; and obtaining the first movement information of the initial position of the test tube rack relative to the sample injection area of the test tube rack when the first position point in the first cavity of the test tube rack reaches the detection position and the second movement information of the test tube rack relative to the initial position when the second position point in the first cavity reaches the detection position according to the third movement information, the parameters of the test tube rack, the first distance value and the second distance value.

In some embodiments, the standard distance may be preset by the user.

It should be noted that, after the test tube rack 102 moves a standard distance relative to the starting position 101 of the sample injection area of the test tube rack, the second side edge of the interval area has passed or is located at the detection position (i.e., the second side edge of the interval area has blocked or is blocking the photoelectric signal emitted by the first photoelectric emitter 1031). The interval area is an area between the first side edge of the test tube rack 102 and an adjacent cavity of the first side edge of the test tube rack, the first side edge of the interval area is the same as the first side edge of the test tube rack and is a side far away from the starting position, the second side edge of the interval area is the first side edge of the adjacent cavity, and the first side edge of the adjacent cavity is a side far away from the starting position.

In the embodiment of the present application, for the spacer region, please refer to fig. 3B. As shown in fig. 3B, the space 1021 is located between the first side edge 1022 of the test tube rack and the adjacent cavity 1023 of the first side edge 1022.

In some embodiments, if the first side edge of the first cavity is a side of the first cavity away from the starting position, the first cavity is the adjacent cavity, and the parameter of the test tube rack includes a distance value between the first side edge of the test tube rack and the first side edge of the first cavity, where the distance value is used to characterize an actual width of the spacing region.

In practice, the sample transmission device 10 generally includes a deviation in mounting positions of the first photoelectric emitter 1031 and the first photoelectric receiver 1032, a difference in photoelectric performance of the first photoelectric emitter 1031, and an environmental disturbance. In the process of moving the test tube rack 102 by a standard distance relative to the initial position of the test tube rack sample injection area 101, there is often a situation that the interval area of the test tube rack 102 shields the photoelectric signal emitted by the first photoelectric emitter 1031, but the intensity of the photoelectric signal received by the first photoelectric receiver 1032 is not 0, so that the position of the test tube rack 102 cannot be accurately positioned, and the accuracy of the first movement information and the second movement information is affected. In order to overcome the problem, the first side edge of the test tube rack is positioned to obtain the third movement information of the test tube rack relative to the initial position when the first side edge of the test tube rack reaches the detection position after the test tube rack moves by the standard distance relative to the initial position.

In some embodiments, after determining that the test tube rack moves a standard distance relative to the initial position, when the first side edge of the test tube rack is at the detection position, the third movement information of the test tube rack relative to the initial position may include: according to the second intensity threshold value, fourth movement information of the test tube rack relative to the initial position is obtained from the first corresponding relation when the middle position of the interval region reaches the detection position; and obtaining third movement information of the test tube rack relative to the initial position when the first side edge of the test tube rack reaches the detection position according to the fourth movement information and the measurement width information of the interval region.

In the embodiment of the application, the first corresponding relation is used for representing the relation between the movement information and the signal intensity of the photoelectric signal acquired by the first photoelectric receiver in the process of moving the initial position of the test tube rack relative to the test tube sample injection area by the standard distance.

In some embodiments, the first correspondence establishment procedure may be as follows: in the process of moving the standard distance of the test tube rack relative to the initial position of the test tube sample injection area, the moving distance value can be periodically acquired, the photoelectric signal intensity corresponding to the acquired moving distance value is further acquired, and the first corresponding relation is obtained according to the acquired moving distance value and the photoelectric signal intensity corresponding to each moving distance value. It can be appreciated that the abscissa of the first correspondence is a periodically acquired movement distance value; the ordinate of the first correspondence is the signal intensity corresponding to each moving distance value.

The second intensity threshold may be obtained through a number of experimental tests and analyses, and may be between 4 and 5, and by way of example, the second intensity threshold may be 4, 4.001, 4.01, 4.1, etc., and embodiments of the present application are not limited thereto.

For example, referring to fig. 3C, fig. 3C is a diagram of a first correspondence relationship. The abscissa of the first correspondence relationship shown in fig. 3C is a moving distance value, and the ordinate is an AD value.

The measured width information of the spacing region is used to characterize the measured width of the spacing region. In an embodiment of the present application, the measurement width information of the interval region may include a measurement width value.

In some embodiments, the measured width value of the spaced area may be actually measured by the user using a ruler.

In some embodiments, the measured width value of the spacing region may also be derived from a second correspondence obtained under theoretical conditions. The theoretical case may be indicated as follows: the first photo-emitter 1031 and the first photo-receiver 1032 on the sample transmission device 10 have no deviation in mounting positions, the first photo-emitter 1031 has no deviation in photo-performance, and no environmental interference.

The second corresponding relation is used for representing the relation between the movement information and the signal intensity of the photoelectric signal acquired by the first photoelectric receiver in the process that the initial position of the test tube rack relative to the test tube sample injection area moves by the standard distance under the theoretical condition. For an example, refer to fig. 3D for a diagram of the second correspondence.

Under the theoretical condition, in the process of moving the test tube rack by a standard distance relative to the initial position of the sample injection area of the test tube rack, if the interval area of the test tube rack reaches the detection position, the photoelectric signal emitted by the first photoelectric emitter is often shielded, and at this time, the intensity of the photoelectric signal received by the first photoelectric receiver is 0. Therefore, only the first moving distance value and the second moving distance value of which the signal intensities are not 0 to 0 and the second moving distance value of which the signal intensities are not 0 are found in the second corresponding relation, and the distance difference between the first moving distance value and the second moving distance value is calculated to obtain the measured width value of the interval region.

In some embodiments, when the first side edge of the test tube rack is obtained to the detection position according to the fourth movement information and the measurement width information of the interval area, the third movement information of the test tube rack relative to the starting position may include, but is not limited to, the following ways:

mode 1, regarding a half of a measured width value included in measured width information of an interval region as a first width value; and subtracting the first width value from the moving distance value included in the fourth moving information to obtain third moving information of the test tube rack relative to the initial position when the first side edge of the test tube rack reaches the detection position.

And 2, subtracting the measured width value included in the measured width information of the interval area from the moving distance value included in the fourth moving information by two times to obtain third moving information of the test tube rack relative to the initial position when the first side edge of the test tube rack reaches the detection position.

By implementing the method, first, the fourth movement information of the test tube rack relative to the initial position is obtained from the first corresponding relation by utilizing the second intensity threshold value when the middle position of the interval region reaches the detection position, and then the actual movement information of the test tube rack relative to the initial position is obtained from the first side edge of the test tube rack to the detection position according to the fourth movement information and the measurement width information of the interval region, so that the positioning deviation caused by the mounting position deviation of the photoelectric transmitter and the photoelectric receiving plate of the photoelectric sensor, the photoelectric performance difference of the photoelectric sensor and the environmental interference is reduced, and the accurate positioning of the test tube rack is realized, thereby being beneficial to accurately positioning the first movement information and the second movement information.

In some embodiments, when the detection position is obtained from the intermediate position of the interval region in the first correspondence according to the second intensity threshold, the fourth movement information of the test tube rack relative to the starting position may include: from the first corresponding relation, determining fifth movement information and sixth movement information with corresponding signal strength being a second strength threshold value; and obtaining fourth movement information of the test tube rack relative to the initial position when the middle position of the interval region obtains the detection position according to the fifth movement information and the sixth movement information.

In some embodiments, the fifth movement information and the sixth movement information may each include a movement distance value of the test tube rack relative to the start position when the corresponding signal strength is the second strength threshold. The first correspondence may include a falling band and a rising band (as shown in fig. 3C), and the signal strengths corresponding to the falling band and the rising band each include a second strength threshold. It may be appreciated that the movement distance value included in the fifth movement information may be a distance value corresponding to the second intensity threshold in the falling band, and the movement distance value included in the sixth movement information may be a distance value corresponding to the second intensity threshold in the rising band.

In some embodiments, the number of the first correspondence may include one or more, which is not limited by the implementation of the present application. It can be understood that, in the case where the first correspondence is one, the number of the fifth movement information and the sixth movement information is one; when the first correspondence is plural, the number of the fifth movement information and the number of the sixth movement information are plural, wherein the number of the first correspondence, the number of the fifth movement information and the number of the sixth movement information are the same.

In some embodiments, when the intermediate position of the interval region is obtained to the detection position according to the fifth movement information and the sixth movement information, the fourth movement information of the test tube rack relative to the initial position may include, but is not limited to, the following ways:

in the mode 1, when the number of the first correspondence relationships is one, the moving distance value included in the fifth moving information and the moving distance value included in the sixth moving information are averaged to obtain fourth moving information of the test tube rack relative to the initial position when the middle position of the interval region reaches the detection position;

mode 2, when the number of the first correspondences is plural, averaging the moving distance value included in the fifth moving information and the moving distance value included in the sixth moving information of each first correspondences to obtain seventh moving information of each first correspondences; the number of the seventh moving information is the same as the number of the first corresponding relation; and obtaining fourth movement information of the test tube rack relative to the initial position when the middle position of the interval region obtains the detection position according to the seventh movement information.

In some embodiments, when the intermediate position of the interval region is obtained from each seventh movement information to obtain the detection position, the fourth movement information of the test tube rack relative to the initial position may include, but is not limited to, the following ways:

In embodiment 1, when the average value of the movement distance values included in the seventh movement information is used as the intermediate position of the interval region to obtain the detection position, the test tube rack is moved with respect to the fourth movement information of the initial position.

Mode 2 is a fourth movement information of the test tube rack with respect to the initial position when the detection position is obtained by using the median of the movement distance values included in each of the seventh movement information as the intermediate position of the interval region.

Mode 3 is a fourth movement information of the test tube rack with respect to the initial position when the detection position is obtained by using the mode of the movement distance value included in each of the seventh movement information as the intermediate position of the interval region.

By implementing the method, the fourth movement information is obtained based on a plurality of first corresponding relations, the acquisition precision of the third movement information can be greatly improved, and the positioning precision of the first movement information and the second movement information is further improved.

In some embodiments, according to the third movement information, the parameter of the test tube rack, the first distance value, and the second distance value, when the first position point in the first cavity of the test tube rack reaches the detection position, the first movement information of the test tube rack relative to the starting position of the sample injection area of the test tube rack, and when the second position point in the first cavity reaches the detection position, the second movement information of the test tube rack relative to the starting position may include:

Obtaining first movement information of the initial position of the test tube rack relative to the sample injection area of the test tube rack when a first position point in a first cavity of the test tube rack reaches a detection position by using a distance value included in the third movement information and a spacing distance value and a first distance value; and obtaining second movement information of the test tube rack relative to the initial position when the second position point in the first cavity reaches the detection position by using the distance value added with the interval distance value and the second distance value included in the third movement information.

302. A first signal strength of an optoelectronic signal between the first movement information and the second movement information is acquired.

It should be noted that, in the embodiment of the present application, for the description of step 302, please refer to the description of step 202 in the embodiment shown in fig. 2, and the description is omitted here.

303. When the first signal intensity is within the target intensity interval, it is determined that no cuvette is present in the first cavity.

In an embodiment of the present application, the following steps may be further performed before step 303:

before the test tube rack does not move, if the second signal intensity of the photoelectric signal received by the first photoelectric receiver is a first intensity threshold value, a first duty ratio corresponding to the first photoelectric transmitter is obtained;

Controlling the first photoelectric transmitter to work at half of a first duty ratio, and acquiring third signal intensity of a photoelectric signal received by the first photoelectric receiver;

and determining a target intensity interval according to the third signal intensity under the condition that the third signal intensity is more than half of the first intensity threshold.

It can be appreciated that, in the case of powering on the sample transmission device 10, first, the duty ratio of the first photoelectric transmitter may be gradually increased according to the fixed frequency until the second signal strength of the photoelectric signal received by the first photoelectric receiver reaches the first strength threshold, where the duty ratio of the first photoelectric transmitter is taken as the first duty ratio, and the increase of the duty ratio of the first photoelectric transmitter is stopped; and then, controlling the first photoelectric transmitter to work at half of the first duty ratio, and acquiring third signal intensity of the photoelectric signal received by the first photoelectric receiver at the moment, wherein if the third signal intensity is greater than half of the first intensity threshold value, the target intensity interval can be determined according to the third signal intensity.

In the embodiment of the present application, if the third signal strength is less than or equal to half of the first strength threshold, 1% is added to half of the first duty cycle to obtain the second duty cycle, and the first photoelectric transmitter is controlled to work with the second duty cycle, and the fourth signal strength of the photoelectric signal received by the first photoelectric receiver is obtained, and the target strength interval is determined according to the fourth signal strength. 1% was obtained by a large number of experiments.

In some embodiments, determining the target intensity interval from the third signal intensity may include: and determining a target intensity interval according to the third signal intensity and the preset floating quantity. The preset floating amount is larger than 0, the upper limit of the target intensity interval is obtained by adding the third signal intensity to the preset floating amount, and the lower limit intensity of the target intensity interval is obtained by subtracting the preset floating amount from the third signal intensity.

Wherein the first intensity threshold may be represented by an AD value, and the first intensity threshold may be 160, 170 or 180. In the embodiment of the application, if the first intensity threshold is 180, and the third signal intensity is represented by A, A is greater than 180/2. The preset float amount may also be represented by an AD value, and may be 8, 9, 10, or the like. If the preset float is 10, the target intensity interval may be expressed as [ A+10, A-10].

304. And when the first signal intensity is smaller than the lower limit intensity of the target intensity interval, calculating a first intensity difference value between the maximum first signal intensity and the lower limit intensity.

The number of the first signal intensities may be plural, and the first intensity difference may be obtained by subtracting the maximum first signal intensity from the lower limit intensity.

305. And when the first intensity difference is larger than a first difference threshold, determining that a test tube with the sample liquid reaching a preset height exists in the first cavity.

Wherein the first difference threshold may be obtained through a number of experiments.

306. And when the first intensity difference is smaller than or equal to the first difference threshold value, determining that a test tube with the sample liquid not reaching the preset height exists in the first cavity.

In some embodiments, when the first signal intensity is less than the lower intensity limit of the target intensity interval, the height detection of the cuvette sample liquid may include, but is not limited to, the following:

mode 1, calculating a first average signal intensity of the first signal intensity, and calculating a second intensity difference value between the average signal intensity and the lower limit intensity, if the second intensity difference value is greater than a second difference value threshold value, a test tube with a sample liquid reaching a preset height exists in the first cavity, otherwise, a test tube with a sample liquid not reaching the preset height exists in the first cavity.

And 2, calculating the median of the first signal intensity, and calculating a third intensity difference value between the median and the lower limit intensity, wherein if the third intensity difference value is larger than a third difference value threshold value, a test tube with the sample liquid reaching the preset height exists in the first cavity, otherwise, a test tube with the sample liquid not reaching the preset height exists in the first cavity.

And 3, calculating second average signal intensity corresponding to the mode in the first signal intensity, and calculating fourth intensity difference between the second average signal intensity and the lower limit intensity, wherein if the fourth intensity difference is larger than a fourth difference threshold value, a test tube with the sample liquid reaching the preset height exists in the first cavity, otherwise, a test tube with the sample liquid not reaching the preset height exists in the first cavity.

It should be noted that the first difference threshold, the second difference threshold, the third difference threshold, and the fourth difference threshold may be obtained through a plurality of experiments.

By implementing the method, under the condition that the test tube exists in the first cavity, whether the height of the sample liquid in the test tube reaches the preset height can be further judged according to the first signal intensity and the lower limit intensity of the target intensity interval, and the efficient identification of the condition of the test tube corresponding to the cavity on the test tube rack is further realized.

Referring to fig. 4, fig. 4 is a block diagram illustrating a sample transmission apparatus according to an embodiment of the present application. May include:

a determining unit 401, configured to determine first movement information of a starting position of the test tube rack relative to the sample injection area of the test tube rack when a first position point in the first cavity of the test tube rack reaches a detection position, and second movement information of the test tube rack relative to the starting position when a second position point in the first cavity reaches the detection position; the first cavity is any one of a plurality of cavities on the test tube rack, the distance value between the first position point and the first side edge of the first cavity is a first distance value, and the distance value between the second position point and the first side edge of the first cavity is a second distance value;

An acquisition unit 402 for acquiring a first signal strength of the photoelectric signal between the first movement information and the second movement information;

and the analysis unit 403 is configured to determine a test tube condition corresponding to the first cavity according to the first signal intensity.

In some embodiments, the manner in which the obtaining unit 402 is configured to obtain the first signal strength of the photoelectric signal between the first movement information and the second movement information may specifically include:

an acquiring unit 402, configured to acquire a first signal strength of a photoelectric signal between first movement information and second movement information from a photoelectric signal acquired by a first photoelectric receiver during a movement process of a test tube rack;

or,

and an acquisition unit 402, configured to acquire, through the first photoelectric receiver, a first signal strength of a photoelectric signal between the first movement information and the second movement information during movement of the test tube rack.

In some embodiments, the manner in which the analysis unit 403 is configured to determine, according to the first signal strength, the condition of the test tube corresponding to the first cavity may specifically include: an analysis unit 403, configured to determine that no cuvette exists in the first cavity when the first signal intensity is within the target intensity interval; and determining that the test tube exists in the first cavity when the first signal intensity is smaller than the lower limit intensity of the target intensity interval.

In some embodiments, the analysis unit 403 is configured to determine that a cuvette is present in the first cavity when the first signal intensity is less than the lower limit intensity of the target intensity interval, including: an analysis unit 403, configured to calculate a first intensity difference between the maximum first signal intensity and the lower limit intensity when the first signal intensity is less than the lower limit intensity of the target intensity interval; when the first intensity difference value is larger than a first difference value threshold value, determining that a test tube with a preset height is reached by the sample liquid in the first cavity; and when the first intensity difference value is smaller than or equal to the first difference value threshold value, determining that a test tube with the sample liquid not reaching the preset height exists in the first cavity.

In some embodiments, the determining unit 401 is further configured to, before the test tube rack is not moved, obtain a first duty cycle corresponding to the first photoelectric transmitter if the second signal strength of the photoelectric signal received by the first photoelectric receiver is a first strength threshold; controlling the first photoelectric transmitter to work at half of a first duty ratio, and acquiring third signal intensity of a photoelectric signal received by the first photoelectric receiver; and determining a target intensity interval according to the third signal intensity under the condition that the third signal intensity is more than half of the first intensity threshold.

In some embodiments, the determining unit 401 is configured to determine, when the first position point in the first cavity of the test tube rack is at the detection position, first movement information of the test tube rack relative to the start position of the sample injection area of the test tube rack, and when the second position point in the first cavity is at the detection position, second movement information of the test tube rack relative to the start position, where the first movement information includes: a determining unit 401, configured to determine third movement information of the test tube rack relative to the initial position when the first side edge of the test tube rack reaches the detection position after the test tube rack moves a standard distance relative to the initial position; the edge of the first side of the test tube rack is the side far away from the initial position; and obtaining first movement information of the initial position of the test tube rack relative to the sample injection area of the test tube rack when a first position point in the first cavity of the test tube rack reaches a detection position and second movement information of the test tube rack relative to the initial position when a second position point in the first cavity reaches the detection position according to the third movement information, the parameters of the test tube rack, the first distance value and the second distance value.

In some embodiments, the first side edge of the first cavity is a side of the first cavity away from the starting position, the first cavity is an adjacent cavity of the first side edge of the test tube rack, and the parameters of the test tube rack include a distance value between the first side edge of the test tube rack and the first side edge of the first cavity;

Further, the determining unit 401 is configured to obtain, according to the third movement information, the parameter of the test tube rack, the first distance value, and the second distance value, first movement information of a starting position of the test tube rack relative to the sample injection area of the test tube rack when a first position point in the first cavity of the test tube rack reaches a detection position, and second movement information of the test tube rack relative to the starting position when a second position point in the first cavity reaches the detection position, where the modes specifically include: a determining unit 401, configured to obtain first movement information of a starting position of the test tube rack relative to the sample injection area of the test tube rack when a first position point in the first cavity of the test tube rack reaches a detection position by using a distance value included in the third movement information and adding the interval distance value and the first distance value; and obtaining second movement information of the test tube rack relative to the initial position when the second position point in the first cavity reaches the detection position by using the distance value added with the interval distance value and the second distance value included in the third movement information.

In some embodiments, the first side edge of the first cavity is a side distal from the starting position, the first distance value and the second distance value are both less than a radius of the first cavity, and the first distance value is less than the second distance value.

In some embodiments, the first distance value is 1/7 of the first cavity diameter and the second distance value is 1/3 of the first cavity diameter.

Referring to fig. 5, fig. 5 is a block diagram illustrating a sample transmission apparatus according to an embodiment of the present application.

May include

A memory 501 in which executable program codes are stored;

and a processor 502 coupled to the memory 501.

The processor 502 invokes executable program code stored in the memory 501, which when executed by the processor 502 causes the processor 502 to implement the method as described in the above embodiments.

The embodiments of the present application disclose a computer readable storage medium storing a computer program, wherein the computer program when executed by a processor implements the method as described in the above embodiments.

Embodiments of the present application disclose a computer program product comprising a non-transitory computer readable storage medium storing a computer program, which when executed by a processor, implements a method as described in the above embodiments.

Those skilled in the art will appreciate that all or part of the processes in the methods of the above embodiments may be implemented by a computer program for instructing relevant hardware, where the program may be stored in a non-volatile computer readable storage medium, and where the program, when executed, may include processes in the embodiments of the methods described above. Wherein the storage medium may be a magnetic disk, an optical disk, a ROM, etc.

Any reference to memory, storage, database, or other medium as used herein may include non-volatile and/or volatile memory. Suitable nonvolatile memory can include ROM, programmable ROM (PROM), erasable PROM (EPROM), electrically Erasable PROM (Electrically Erasable PROM, EEPROM), or flash memory. Volatile memory can include random access memory (random access memory, RAM), which acts as external cache memory. By way of illustration and not limitation, RAM may take many forms, such as Static RAM (SRAM), dynamic RAM (Dynamic Random Access Memory, DRAM), synchronous DRAM (SDRAM), double Data Rate SDRAM (DDR SDRAM), enhanced SDRAM (Enhanced Synchronous DRAM, ESDRAM), synchronous Link DRAM (SLDRAM), memory bus Direct RAM (Rambus DRAM), and Direct memory bus dynamic RAM (DRDRAM).

It should be appreciated that reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment of the present application. Thus, the appearances of the phrases "in one embodiment" or "in an embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments. Those skilled in the art will also appreciate that the embodiments described in the specification are alternative embodiments and that the acts and modules referred to are not necessarily required for the present application.

In various embodiments of the present application, it should be understood that the sequence numbers of the foregoing processes do not imply that the execution sequences of the processes should be determined by the functions and internal logic of the processes, and should not be construed as limiting the implementation of the embodiments of the present application.

The functional units in the embodiments of the present application may be integrated in one processing unit, or each unit may exist alone physically, or two or more units may be integrated in one unit. The integrated units may be implemented in hardware or in software functional units.

The integrated units described above, if implemented in the form of software functional units and sold or used as stand-alone products, may be stored in a computer-accessible memory. Based on this understanding, the technical solution of the present application, or a part contributing to the prior art or all or part of the technical solution, may be embodied in the form of a software product stored in a memory, comprising several requests for a computer device (which may be a personal computer, a server or a network device, etc., in particular may be a processor in a computer device) to execute some or all of the steps of the above-mentioned method of the various embodiments of the present application.

The above describes in detail a test tube detection method and a sample transmission device disclosed in the embodiments of the present application, and specific examples are applied herein to illustrate the principles and embodiments of the present application, and the above description of the examples is only for helping to understand the method and core ideas of the present application. Meanwhile, as those skilled in the art will have variations in the specific embodiments and application scope in accordance with the ideas of the present application, the present description should not be construed as limiting the present application in view of the above.

Claims

1. A method of cuvette detection, the method comprising:

after determining that the test tube rack moves a standard distance relative to a starting position, when the first side edge of the test tube rack reaches a detection position, third movement information of the test tube rack relative to the starting position is obtained; the first side edge of the test tube rack is a side far away from the initial position;

obtaining first movement information of a starting position of the test tube rack relative to a sample injection area of the test tube rack when a first position point in a first cavity of the test tube rack reaches the detection position and second movement information of the test tube rack relative to the starting position when a second position point in the first cavity reaches the detection position according to the third movement information, the parameters of the test tube rack, the first distance value and the second distance value; the first cavity is any one of a plurality of cavities on the test tube rack, a distance value between the first position point and the first side edge of the first cavity is the first distance value, and a distance value between the second position point and the first side edge of the first cavity is the second distance value;

2. The method of claim 1, wherein the first photosensor comprises a first photoelectric receiver, the acquiring a first signal strength of a photoelectric signal between the first movement information and the second movement information comprising:

3. The method of claim 1, wherein the first photosensor comprises a first photoelectric receiver, the acquiring a first signal strength of a photoelectric signal between the first movement information and the second movement information comprising:

4. A method according to any one of claims 1-3, wherein said determining, based on said first signal strength, a tube condition corresponding to said first cavity comprises:

5. The method of claim 4, wherein determining that a cuvette is present in the first cavity when the first signal strength is less than a lower strength of a target strength interval comprises:

6. The method of claim 4, wherein the first photosensor comprises a first photosensor and a first photoemitter, and wherein the method further comprises, prior to determining the cuvette condition corresponding to the first cavity based on the first signal strength:

7. The method of claim 1, wherein the first side edge of the first cavity is a side of the first cavity away from the starting position, the first cavity is an adjacent cavity to the first side edge of the test tube rack, and the parameters of the test tube rack include a distance value between the first side edge of the test tube rack and the first side edge of the first cavity;

8. The method of claim 1, wherein the first side edge of the first cavity is a side distal from the starting location, the first distance value and the second distance value are each less than a radius of the first cavity, and the first distance value is less than the second distance value.

9. The method of claim 8, wherein the first distance value is 1/7 of a diameter of the first cavity and the second distance value is 1/3 of the diameter of the first cavity.

10. A sample transmission device, comprising:

the determining unit is used for determining third movement information of the test tube rack relative to the initial position when the first side edge of the test tube rack reaches the detection position after the test tube rack moves a standard distance relative to the initial position; the first side edge of the test tube rack is a side far away from the initial position; obtaining first movement information of a starting position of the test tube rack relative to a sample injection area of the test tube rack when a first position point in a first cavity of the test tube rack reaches the detection position and second movement information of the test tube rack relative to the starting position when a second position point in the first cavity reaches the detection position according to the third movement information, the parameters of the test tube rack, the first distance value and the second distance value; the first cavity is any one of a plurality of cavities on the test tube rack, a distance value between the first position point and the first side edge of the first cavity is the first distance value, and a distance value between the second position point and the first side edge of the first cavity is the second distance value;

11. A sample transmission device, comprising:

a memory storing executable program code;

and a processor coupled to the memory;

the processor invoking the executable program code stored in the memory, which when executed by the processor, causes the processor to implement the method of any of claims 1-9.