CN113990395A - Artificial intelligence antibacterial agent developments monitoring device - Google Patents
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- CN113990395A CN113990395A CN202111095698.6A CN202111095698A CN113990395A CN 113990395 A CN113990395 A CN 113990395A CN 202111095698 A CN202111095698 A CN 202111095698A CN 113990395 A CN113990395 A CN 113990395A
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Abstract
The invention relates to an artificial intelligent antibacterial drug dynamic monitoring device, which comprises: a gene measuring unit for measuring the number of drug-resistant genes; and the analysis and judgment unit is used for obtaining the drug resistance degree of the corresponding antibacterial drugs based on the number of the drug resistance genes measured by the gene sequencing unit. The invention is based on the high organic combination of molecular biology technology and computer technology, summarizes and designs the existing known drug-resistant gene determination primer, utilizes the rapid and accurate advantage of gene sequencing, carries out comprehensive data analysis on the central axial relation of the bacterial drug-resistant gene-drug-resistant bacteria through a statistical model, realizes the bedside rapid detection of the number of the drug-resistant gene and the real-time monitoring of functional abundance of the patient on the application effect of the antibacterial drug, helps the clinician to adjust the drug use in time, and can guide the scientific and reasonable family drug use of the patient.
Description
Technical Field
The invention relates to the technical field of artificial intelligence, in particular to an artificial intelligence dynamic monitoring device for an antibacterial drug.
Background
Antibiotics are one of the greatest medical findings in human history, saving the lives of countless patients. However, with the overuse of antibacterial drugs, the occurrence of bacterial drug resistance to antibacterial drugs is rare, and with the appearance of more and more "superbacteria", it becomes important to effectively detect drug resistance and avoid overuse.
Traditional methods of microorganism identification rely on phenotypic identification, mainly staining, culturing and simple biochemical tests. The indexes for monitoring the in vitro pharmacodynamics of the antibacterial drug mainly comprise: bacterial sensitivity (MIC/MBC); antibiogram (antibiogram mechanism); (iii) antibacterial character (bactericidal/bacteriostatic); fourthly, antibacterial post-effect (PAE); fifthly, combining antibacterial agents.
Although the traditional identification method is still widely used, the method has two defects: they are only suitable for microorganisms that can be cultured in vitro, and some strains exhibit unique biochemical properties that do not conform to known species patterns; another problem is that the culture period is too long, the bacteria are in a dynamic process in the human body, the effect of the antibacterial drug is related to the concentration/time, the composition of pathogenic bacteria and the application curative effect of the pathogenic bacteria on the antibacterial drug are determined in time, and the composition and the application curative effect are closely related to the prognosis of a patient.
With the development of biotechnology in the 21 st century, "gene sequencing" has been widely used in a variety of basic and clinical studies and commercial tests because it does not rely on living cultures and often reveals subtle differences between organisms that cannot be detected by traditional methods. By reading the microbial gene information, the accuracy rate and the cycle period of clinical pathogen identification are greatly improved. At present, the identification of microorganisms by using microbial gene sequences mainly comprises the following steps: PCR identification (such as qPCR); identifying the microarray chip; and sequencing next generation gene. However, the diagnosis and antibacterial treatment of infection by doctors still remain in a single static layer such as biochemical analysis of the types of microorganisms and their metabolites, and the timeliness, sensitivity and comprehensiveness of gene sequencing cannot be fully applied to clinical application.
Based on this, the prior art still remains to be improved.
Disclosure of Invention
The invention aims to solve the problems and provides an artificial intelligent antibacterial drug dynamic monitoring device, which obtains an antibiotic drug resistance evaluation result through gene sequencing.
In order to achieve the purpose, the invention adopts the following technical scheme:
the embodiment of the invention discloses an artificial intelligent antibacterial drug dynamic monitoring device, which comprises:
a gene measuring unit for measuring the number of drug-resistant genes;
and the analysis and judgment unit is used for obtaining the drug resistance degree of the corresponding antibacterial drugs based on the number of the drug resistance genes measured by the gene sequencing unit.
In the gene determination unit, the determination of the number of drug-resistant genes can be accomplished by the following method: quantitative PCR (e.g., qPCR); microarray chip identification techniques; the next generation gene sequencing technology is realized.
Further, the analysis and judgment unit further includes: and obtaining an antibiotic resistance enrichment result through hyper-geometric distribution calculation analysis according to the corresponding relation between different drug resistance genes and different antibiotics, and outputting an analysis result based on the antibiotic resistance enrichment result.
Further, the analysis results include recommended relevant antibiotics and medication adjustment regimens.
Further, the determining the number of the drug-resistant genes comprises:
determining the number m of genes which can be determined from known drug-resistant genes in the sample,
obtaining a gene factor a contained in a certain antibiotic drug-resistant gene group in the quantity-increasing gene group;
the gene factor b contained in a certain antibiotic resistance gene group in the gene group with unchanged quantity;
a gene factor c excluding a in the population of elevated numbers;
the number of genes was unchanged except for the number d of genes in the population.
Further, the analysis unit includes: the P value is calculated by using a formula (I),
wherein C is a combination in the permutation and combination,
the number of combinations of n elements from m different elements;
and obtaining a drug resistance conclusion based on the comparison result of the P value and the preset value.
Further, if the P value is less than 0.05, the drug resistance is considered.
Further, the smaller the P value, the stronger the drug resistance was considered.
The invention has the beneficial effects that:
the invention is based on the high organic combination of molecular biology technology and computer technology, summarizes and designs the existing known drug-resistant gene determination primer, utilizes the rapid and accurate advantage of gene sequencing, carries out comprehensive data analysis on the central axial relation of the bacterial drug-resistant gene-drug-resistant bacteria through a statistical model, realizes the bedside rapid detection of the number of the drug-resistant gene and the real-time monitoring of functional abundance of the patient on the application effect of the antibacterial drug, helps the clinician to adjust the drug use in time, and can guide the scientific and reasonable family drug use of the patient.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the following embodiments of the present invention are described in further detail with reference to specific embodiments.
It should be noted that all expressions using "first" and "second" in the embodiments of the present invention are used for distinguishing two entities with the same name but different names or different parameters, and it should be noted that "first" and "second" are merely for convenience of description and should not be construed as limitations of the embodiments of the present invention, and they are not described in any more detail in the following embodiments.
An embodiment of the invention discloses an artificial intelligence antibacterial drug dynamic monitoring device, which comprises:
a gene measuring unit for measuring the number of drug-resistant genes;
and the analysis and judgment unit is used for obtaining the drug resistance degree of the corresponding antibacterial drugs based on the number of the drug resistance genes measured by the gene sequencing unit.
The analysis determination unit includes: and obtaining an antibiotic resistance enrichment result through hyper-geometric distribution calculation analysis according to the corresponding relation between different drug resistance genes and different antibiotics, and outputting an analysis result based on the antibiotic resistance enrichment result. And recommending related antibiotics and medication adjustment schemes according to the analysis result.
In some embodiments, based on the above embodiments, the determining the number of drug resistance genes comprises:
determining the number m of genes which can be determined from known drug-resistant genes in the sample,
obtaining a gene factor a contained in a certain antibiotic drug-resistant gene group in the quantity-increasing gene group;
the gene factor b contained in a certain antibiotic resistance gene group in the gene group with unchanged quantity;
a gene factor c excluding a in the population of elevated numbers;
the number of genes was unchanged except for the number d of genes in the population.
The analysis unit includes: the P value is calculated by using a formula (I),
wherein C is a combination in the permutation and combination,
the number of combinations of n elements from m different elements;
and obtaining a drug resistance conclusion based on the comparison result of the P value and the preset value.
The drug resistance is considered to be stronger when the P value is smaller, and drug resistance is considered to be present when the P value is smaller than 0.05.
In the initial data model building process, the micro-ecological gene determination is carried out by adopting the metagenomics, the accuracy of the known drug resistance gene is verified, and the unknown potential drug resistance gene is predicted. Combining the abundance information and the phenotype information of the functional genes obtained by sequencing the metagenome of the patient, namely integrating the antibiotic resistance or the antibiotic intolerance, mining the genes related to each antibiotic resistance by using a machine learning algorithm (classification, regression, clustering and the like), and evaluating the corresponding effect values. Thereby establishing a network relationship tree between genes and phenotypes.
After the fixed and drug-resistant related genome is screened out, the gene sequencing technology or chip technology is utilized to input the primer information of the fixed genome into a mass spectrometer, and the number of the sequences of the fixed genome is rapidly detected to obtain the abundance information of the fixed genome. And obtaining an antibiotic resistance enrichment result through hyper-geometric distribution calculation analysis according to the corresponding relation between different drug resistance genes and different antibiotics, and intelligently recommending related antibiotics and medication adjustment schemes.
The invention provides a primer design scheme (429, see table 1 and a sequence table) required by a method for determining the number of drug-resistant genes based on a quantitative PCR mode.
TABLE 1
Examples
Gene measuring unit
Using quantitative PCR (e.g., qPCR); microarray chip identification techniques; the quantitative detection method of nucleic acid such as the next generation gene sequencing technology and the like realizes the gene quantity measurement, and takes the drug-resistant gene primer designed by the invention as an example, and the quantitative PCR method is used for the measurement.
Taking the dfrA26 gene as an example using LAMP detection reaction:
| primer and method for producing the same | Primer series (5'→ 3') |
| Forward primer | AGGGCGTTTATTCTTCCTATAC |
| Reverse primer | GTCATTGAATCCTGATGTGA |
The method comprises the following steps:
1) extracting DNA;
2) preparing an LAMP detection reaction system, wherein the reaction system comprises primers: forward primer, Reverse primer (0.2. mu.M concentration);
3) and (3) carrying out amplification reaction on the extracted nucleic acid template at 63 ℃ for 1 hour, placing the reaction tube in a water bath at 80 ℃ for 5 minutes to terminate the reaction, and observing green fluorescence intensity or quantifying the DNA concentration by a real-time turbidimeter.
The LAMP detection reaction system is as follows:
dNTPs 1.4mM，Tris-HCl pH＝8.8,20mM，(NH4)2SO4 10mM，KCl 10mM， MgSO48mM, betaine 0.8M, 0.1% Tween 20, Bst DNA polymerase 8U, AMV reverse transcriptase 0.5U, fluorescent dye SYBR green I1. mu.l, dfrA26 gene 2. mu.l.
An analysis and judgment unit:
the total number of known drug-resistant genes is: 742, wherein 11 related genes of trimethoprim (trimethoprim) drug resistance comprise: dfrA26, dfrA12, dfrA14, dfrA17, dfrA5, dfrA8, dfrC, dfrD, dfrF, dfrG, dfrK. The total number of 50 genes (the number of genes a + c of a number-increasing gene group) in 742 genes (known drug resistance genes m) in a sputum sample of a patient is significantly up-regulated, and the 50 up-regulated genes comprise four trimethoprim resistance genes dfrA26, dfrA12, dfrA14 and dfrA17 (the gene factor a contained in a certain antibiotic resistance gene group in the number-increasing gene group), so that the gene factor b contained in a certain antibiotic resistance gene group in a number-unchanged gene group is 11-4-7, and the gene factor d except the gene b in the number-unchanged gene group is 742-50-7 685.
Substitution into the formula:
p value less than 0.01, the patient is presumed to be resistant to trimethoprim.
In conclusion, the artificial intelligent dynamic monitoring device for the antibacterial drugs provided by the invention has the advantages of small volume, high experimental efficiency and labor, material and time saving, is an artificial intelligent instrument capable of rapidly detecting the drug resistance genes of bacteria at the bedside, realizes clinical rapid diagnosis of pathogenic bacteria and sensitivity of pathogenic bacteria to the antibacterial drugs, and guides the drugs in time.
It should be particularly noted that the various components or steps in the above embodiments can be mutually intersected, replaced, added or deleted, and therefore, the combination formed by the reasonable permutation and combination conversion shall also belong to the protection scope of the present invention, and the protection scope of the present invention shall not be limited to the embodiments.
The above is an exemplary embodiment of the present disclosure, and the order of disclosure of the above embodiment of the present disclosure is only for description and does not represent the merits of the embodiment. It should be noted that the discussion of any embodiment above is exemplary only, and is not intended to intimate that the scope of the disclosure, including the claims, of embodiments of the invention is limited to those examples, and that various changes and modifications may be made without departing from the scope, as defined in the claims. The functions, steps and/or actions of the method claims in accordance with the disclosed embodiments described herein need not be performed in any particular order. Furthermore, although elements of the disclosed embodiments of the invention may be described or claimed in the singular, the plural is contemplated unless limitation to the singular is explicitly stated.
Those of ordinary skill in the art will understand that: the discussion of any embodiment above is meant to be exemplary only, and is not intended to intimate that the scope of the disclosure, including the claims, of embodiments of the invention is limited to these examples; within the idea of an embodiment of the invention, also technical features in the above embodiment or in different embodiments may be combined and there are many other variations of the different aspects of an embodiment of the invention as described above, which are not provided in detail for the sake of brevity. Therefore, any omissions, modifications, substitutions, improvements, and the like that may be made without departing from the spirit and principles of the embodiments of the present invention are intended to be included within the scope of the embodiments of the present invention.
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<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 36
atgagcaacg atacgactaa 20
<210> 37
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 37
gggattgcga aagttggg 18
<210> 38
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 38
ccgtagatgt ggaagcag 18
<210> 39
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 39
atgcctgctg atgaactg 18
<210> 40
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 40
ccgagattga gaccttgac 19
<210> 41
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 41
gctggtcttc gtcaacaa 18
<210> 42
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 42
cgtactcctt ctcggtca 18
<210> 43
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 43
tctgttctcc gtgatgttc 19
<210> 44
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 44
cgtgtcgtca aggttgat 18
<210> 45
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 45
catcttcggt acggtctc 18
<210> 46
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 46
ttgtagcggt tccacttc 18
<210> 47
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 47
gtgctgtatc tggacgag 18
<210> 48
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 48
catgtactgg gtggtgag 18
<210> 49
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 49
gaagaggatg aagaggatga g 21
<210> 50
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 50
gttggcgtat aacatagtat cg 22
<210> 51
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 51
cgtgaattgg tcatctgtc 19
<210> 52
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 52
agccatagtt cttgaggtag 20
<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 53
tgaagacagt tgcgattatc 20
<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 54
attctcacca taacctccat 20
<210> 55
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 55
gaattagacg ccgccatt 18
<210> 56
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 56
ttgagtgcca gtgtgatg 18
<210> 57
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 57
ctgcgataca ctctcatca 19
<210> 58
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 58
tcatcaactc tgccaacaa 19
<210> 59
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 59
ggaggtcaat cttcggaat 19
<210> 60
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 60
gttgttgctt gtggtgag 18
<210> 61
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 61
aatagtgcgg atgaattgga 20
<210> 62
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 62
tggataacgg ctgtatgac 19
<210> 63
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 63
agtgtcggag tgatgagta 19
<210> 64
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 64
aagtcggtcg ctaaggat 18
<210> 65
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 65
gagaggtggc aagaagtc 18
<210> 66
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 66
cggatagcga aggtgatc 18
<210> 67
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 67
ggagattcca aatcggttc 19
<210> 68
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 68
cgtgtggtac ggatactc 18
<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 69
ctgagattga ccttgccata 20
<210> 70
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 70
tgttgttgct cttgctgaa 19
<210> 71
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 71
cagaggcaga cgactatg 18
<210> 72
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 72
ttgatatgag tgtggactgt 20
<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 73
gtgccatcgc ctatattgaa 20
<210> 74
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 74
gtgtgccatg acagtattat tg 22
<210> 75
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 75
tcttagtggt tgacgatgaa 20
<210> 76
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 76
cttatggctg ctcttgct 18
<210> 77
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 77
tcctgtgttg atgctaact 19
<210> 78
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 78
actcttctga cgatattacg 20
<210> 79
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 79
ggtatcgtgt cattaaggta tc 22
<210> 80
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 80
ataatcgtct gctccaatca 20
<210> 81
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 81
cgattggagc ggatgatt 18
<210> 82
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 82
atctgcggca ttattgtaac 20
<210> 83
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 83
aggagtggtt gttagttcag 20
<210> 84
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 84
cgtggctgtt cgtctaat 18
<210> 85
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 85
atgtaatcca ggctcaatca 20
<210> 86
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 86
tctcaccgaa ctccaaga 18
<210> 87
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 87
tggatgtgat gttacctgat 20
<210> 88
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 88
actactgtcc cttgatgct 19
<210> 89
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 89
cggcatacca atcctgatg 19
<210> 90
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 90
ggcattcgtg aacggatc 18
<210> 91
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 91
aacgcacata gacctatact 20
<210> 92
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 92
caatcgccaa tccaagtc 18
<210> 93
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 93
gcacacctct tacctctg 18
<210> 94
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 94
cttgaataac gacttcctct g 21
<210> 95
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 95
aagactccgc ttacatctg 19
<210> 96
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 96
aaccaactgc tccaacata 19
<210> 97
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 97
cgccttgaag aattattgag 20
<210> 98
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 98
agatgtgtcc attcggtaa 19
<210> 99
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 99
gaccaatgcc aatcgttac 19
<210> 100
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 100
caagaccagt gctatcctc 19
<210> 101
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 101
ccgttcttct tgcgattg 18
<210> 102
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 102
gttgttcagg tgcttcca 18
<210> 103
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 103
ctggtgtctt gctccttg 18
<210> 104
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 104
cgagaagggt ttgtgtgat 19
<210> 105
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 105
actgctgcta agagaatgg 19
<210> 106
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 106
agtgcgtatc cgtattgag 19
<210> 107
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 107
cgcaccttat caccagatt 19
<210> 108
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 108
cggcagtcgt atcaatgt 18
<210> 109
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 109
gtgtcagcgt aagccata 18
<210> 110
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 110
ttgtgagttc ggtcatagg 19
<210> 111
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 111
cggttattga gcgactaca 19
<210> 112
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 112
cgtatgcggt gtgattgt 18
<210> 113
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 113
caagcatcac cgaggaag 18
<210> 114
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 114
tcatcagcat caacatcagt 20
<210> 115
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 115
gggacaactt cactggaa 18
<210> 116
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 116
cgcttcattg ctcgtaat 18
<210> 117
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 117
gcttcggatt gcttctct 18
<210> 118
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 118
agtagacatc tggatatggt tc 22
<210> 119
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 119
aatatcctgt tcgccaaga 19
<210> 120
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 120
gcatcattga ccatctctg 19
<210> 121
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 121
gcgttcatta tctcgttcac 20
<210> 122
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 122
gctcaagttc cacatcgta 19
<210> 123
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 123
aaccttggca tattcgctat 20
<210> 124
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 124
actgttcatc cgctggta 18
<210> 125
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 125
gcaggttata gcgaacataa 20
<210> 126
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 126
tgaagattgg caggcatt 18
<210> 127
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 127
cggtatgtgc cagatgag 18
<210> 128
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 128
tcgcctcctg aatatcca 18
<210> 129
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 129
ccgcaaatgg caaagaaa 18
<210> 130
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 130
tcgttaatcg tagcatcagt 20
<210> 131
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 131
catttaatca ttcgccacag 20
<210> 132
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 132
tatactcttc taaggtccat cc 22
<210> 133
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 133
gcgacaacga gtattcaac 19
<210> 134
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 134
tcaccaccta atccaatcag 20
<210> 135
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 135
cagcgttatt gagcagtc 18
<210> 136
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 136
cttgaaggcg atgtatagc 19
<210> 137
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 137
ggatacacta caccaaccaa 20
<210> 138
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 138
cgaacatagt catacgctaa c 21
<210> 139
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 139
gaagggcagg aagtcaag 18
<210> 140
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 140
gcgagaagtt cacgtagat 19
<210> 141
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 141
gacgaccatc acgagaag 18
<210> 142
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 142
gcgaatcacc atcaccat 18
<210> 143
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 143
gacatcggca tccattcg 18
<210> 144
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 144
gttgaacgga cggaacag 18
<210> 145
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 145
gattattgtc ggtcacttgt 20
<210> 146
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 146
cgccagaaca tcactacta 19
<210> 147
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 147
gccttgcttc actatccg 18
<210> 148
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 148
ttcgctcatc gtaatcttca 20
<210> 149
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 149
tggtatgttg gctatgttga 20
<210> 150
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 150
gctatctgcg ttcgtagg 18
<210> 151
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 151
tgctgcgtta tactcttact 20
<210> 152
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 152
acctgaacct gtcttatgc 19
<210> 153
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 153
tgctgcgtta tactcttact 20
<210> 154
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 154
acctgaacct gtcttatgc 19
<210> 155
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 155
tgctgcgtta tactcttact 20
<210> 156
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 156
acctgaacct gtcttatgc 19
<210> 157
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 157
tgctgcgtta tactcttact 20
<210> 158
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 158
acctgaacct gtcttatgc 19
<210> 159
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 159
tcgtgtctac tgttatgtca 20
<210> 160
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 160
ctggtgtatg tggagttca 19
<210> 161
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 161
cgcatcaatc tcggctata 19
<210> 162
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 162
gacgacgaac acgaactt 18
<210> 163
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 163
gccagttcta caagcagtt 19
<210> 164
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 164
caccagcacg agatacac 18
<210> 165
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 165
ccaggtgagc agaagatt 18
<210> 166
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 166
cgtgattgtg ccttgaat 18
<210> 167
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 167
gaatggagtt atcggaaatg g 21
<210> 168
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 168
atcaccttct ggctcaatg 19
<210> 169
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 169
acggtattat cggtaatgga 20
<210> 170
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 170
tgtatctggg atttcaggaa 20
<210> 171
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 171
ggcacttacc aagagatatg 20
<210> 172
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 172
tgagcaccac caataatga 19
<210> 173
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 173
gggcaaagtg gtcgttat 18
<210> 174
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 174
cgtgattgtg gcttgaac 18
<210> 175
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 175
agcactgacc tataaccaat 20
<210> 176
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 176
aaacgacatc aaacttccc 19
<210> 177
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 177
cgtagaggtc cgcttcaa 18
<210> 178
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 178
taggtgccgt ggttggta 18
<210> 179
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 179
accctgctcc tggatttc 18
<210> 180
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 180
cctgctcgtc cttcttct 18
<210> 181
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 181
cttccaccga cctcaagt 18
<210> 182
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 182
gaacaccacc acgatgac 18
<210> 183
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 183
caaggaccat taccaggaa 19
<210> 184
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 184
gaccaccagg aagaacag 18
<210> 185
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 185
ctgctgttca tcgacctg 18
<210> 186
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 186
gttgaccacc ttgaccac 18
<210> 187
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 187
ggcatcatcg gtgagaac 18
<210> 188
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 188
ttcgtcgagc agcatcag 18
<210> 189
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 189
caacgaaggc gacatcag 18
<210> 190
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 190
cgaccacagg aacaggtt 18
<210> 191
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 191
gtcaaccgct acgaggaa 18
<210> 192
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 192
cagttgctgt tccgagtc 18
<210> 193
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 193
cgacttccga ccagacta 18
<210> 194
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 194
agcagagatg tagccttga 19
<210> 195
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 195
ggctcctcgt attgttgaa 19
<210> 196
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 196
gttgcttgct gaccatct 18
<210> 197
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 197
gcaactctcg caacctaa 18
<210> 198
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 198
cgccgtcata tacttacctt 20
<210> 199
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 199
aatagcagtt gtagcaggtt 20
<210> 200
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 200
gccataggta ataggtataa gc 22
<210> 201
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 201
aatagcagtt gtagcaggtt 20
<210> 202
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 202
gccataggta ataggtataa gc 22
<210> 203
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 203
atccttatcg caccttacg 19
<210> 204
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 204
acctatccta tcgccaaga 19
<210> 205
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 205
cggacttcac ttctcactt 19
<210> 206
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 206
gacaacaatc atcagcgtaa 20
<210> 207
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 207
cgcatcaacc tcgactac 18
<210> 208
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 208
cgcatcaacc tcgactac 18
<210> 209
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 209
atcaagaagg tgttcatcca 20
<210> 210
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 210
acgcaggttc atcatcag 18
<210> 211
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 211
aggtgaccga atccgatg 18
<210> 212
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 212
agcgtctgtt gcgtgaat 18
<210> 213
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 213
atgttgctga gccgaatc 18
<210> 214
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 214
cacgatgcca ttgacctg 18
<210> 215
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 215
gtgatctatc gccagttct 19
<210> 216
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 216
acggttgaag ccattgaa 18
<210> 217
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 217
cacgctgaag acctacga 18
<210> 218
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 218
caccgatgtt ggcattgg 18
<210> 219
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 219
cgatgtgacc aagcattc 18
<210> 220
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 220
gtagacctcg gtgaactc 18
<210> 221
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 221
gtccacgaag atcctgatc 19
<210> 222
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 222
aacggcttgc agatgtag 18
<210> 223
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 223
ctggcgttgg aagaagac 18
<210> 224
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 224
ggatgatgtt gtggctgat 19
<210> 225
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 225
cggctattgg cgagatac 18
<210> 226
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 226
tgacatcaac accacctaat 20
<210> 227
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 227
ttatcgtcgc agaagcatt 19
<210> 228
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 228
ccgtctccac cataatcatt 20
<210> 229
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 229
gcttaggcgt ctcttcttat 20
<210> 230
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 230
ttgttgtcac ttctggttct 20
<210> 231
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 231
gcagcaatga tgatgatgt 19
<210> 232
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 232
tgttccgtcg tcaataatac 20
<210> 233
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 233
ttggatacag acaccttacc 20
<210> 234
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 234
agccgttctc atagacaag 19
<210> 235
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 235
tgctgcgtta tactcttact 20
<210> 236
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 236
acctgaacct gtcttatgc 19
<210> 237
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 237
catcttggtg ttctcattgt 20
<210> 238
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 238
gcattattgt cgctctgg 18
<210> 239
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 239
tgtcgttagt cgcaatcc 18
<210> 240
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 240
catcgcttcc tcacagtc 18
<210> 241
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 241
cggttgttga ggttataggt 20
<210> 242
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 242
tcatagcgtc gtgtcaga 18
<210> 243
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 243
ggtggttact cggattactt 20
<210> 244
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 244
aatgctctgg tgcttgaat 19
<210> 245
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 245
ggaagtgatg tctggatagg 20
<210> 246
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 246
tccgccaacg atagtgta 18
<210> 247
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 247
ctcattattc aggtggtcag a 21
<210> 248
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 248
gttgatattg tctcttggaa gg 22
<210> 249
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 249
atccgttaca tcaccacaa 19
<210> 250
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 250
gaatatactc gtttaggcta cc 22
<210> 251
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 251
atgacattag gcgatgctat 20
<210> 252
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 252
ggcttcttgt tgaggtgta 19
<210> 253
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 253
ctgttagtta cgcctccaa 19
<210> 254
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 254
ggttccaatc ggtcaagt 18
<210> 255
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 255
ttcgcctgtg tattatctcc 20
<210> 256
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 256
gctgttatcg ctcatggta 19
<210> 257
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 257
ttcgcctgtg tattatctcc 20
<210> 258
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 258
gctgttatcg ctcatggta 19
<210> 259
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 259
gccgcataca ctattctca 19
<210> 260
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 260
ttatccgcct ccatccag 18
<210> 261
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 261
gccgcataca ctattctca 19
<210> 262
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 262
ttatccgcct ccatccag 18
<210> 263
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 263
ttgctatgtg gttgcttct 19
<210> 264
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 264
atggcttctc ctagtgtca 19
<210> 265
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 265
gctatgtggt tgcttctct 19
<210> 266
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 266
atggcttctc ctagtgtca 19
<210> 267
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 267
gctatgtggt tgcttctct 19
<210> 268
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 268
atggcttctc ctagtgtca 19
<210> 269
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 269
gaagtgtgcc gctgtatg 18
<210> 270
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 270
tctgctgtgt taatcaatgc 20
<210> 271
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 271
aactctgcgg aatctgac 18
<210> 272
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 272
ttctgcgtta ggttgagg 18
<210> 273
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 273
gttctgctgt cttgtctct 19
<210> 274
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 274
ggcgttatca ctgtattgc 19
<210> 275
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 275
gcagcacact tcctatctc 19
<210> 276
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 276
cgacaacgca ttggcata 18
<210> 277
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 277
ctgttagtta cgcctccaa 19
<210> 278
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 278
gctccaatcg gtcaagtc 18
<210> 279
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 279
agccatacag cgatattgat 20
<210> 280
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 280
gcgagttcca tagcgtta 18
<210> 281
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 281
cgccatgact acgtgaac 18
<210> 282
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 282
ggaaatagac cacccgttc 19
<210> 283
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 283
ttgcttctgc ttctgctt 18
<210> 284
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 284
acaaccgtta ttatcgctac 20
<210> 285
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 285
aagcatcagt cggtgttg 18
<210> 286
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 286
ctcgtggcat tctttctct 19
<210> 287
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 287
ttctcacagc gataacaac 19
<210> 288
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 288
tggcagcagt aattcctt 18
<210> 289
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 289
ggtgaccaat actctgatat ag 22
<210> 290
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 290
cctctgttcc gtactcatt 19
<210> 291
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 291
atgctgagtg gactgaatc 19
<210> 292
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 292
atcggcttcg ctaatactaa 20
<210> 293
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 293
cgttgtggct atgcttgt 18
<210> 294
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 294
ctgcggttgt ctttccata 19
<210> 295
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 295
gatgtcgttg tcgttctct 19
<210> 296
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 296
ggtgttgtcc ttctccag 18
<210> 297
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 297
gacatcatcc tcaacactca 20
<210> 298
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 298
cactccatct caccgaatc 19
<210> 299
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 299
gcgacgacac attatcac 18
<210> 300
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 300
ttaccatcac gagccatac 19
<210> 301
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 301
gcgacgacac attatcac 18
<210> 302
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 302
ttaccatcac gagccatac 19
<210> 303
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 303
gactctgcgt gctgataa 18
<210> 304
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 304
gaatgtggat ggtggtgaa 19
<210> 305
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 305
caggtatgcg tggattgat 19
<210> 306
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 306
ccgtgagttg agatgaagta 20
<210> 307
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 307
ggtatcgccg taggtatg 18
<210> 308
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 308
ccagttccgc aatcttct 18
<210> 309
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 309
gcagtccatc aggttctc 18
<210> 310
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 310
ggaagtgacg gcatacag 18
<210> 311
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 311
atcgttatcc gcttgttga 19
<210> 312
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 312
cgtctaatac cactcttacc ta 22
<210> 313
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 313
gttgatgaag atggagagga 20
<210> 314
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 314
ccgctatacg aatacagttg 20
<210> 315
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 315
gatgctggtc gctgttat 18
<210> 316
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 316
atgaagttgt cgtggttga 19
<210> 317
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 317
gtagcaagtc ttccaggtaa 20
<210> 318
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 318
cacatcggca tcagtcat 18
<210> 319
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 319
cgacaacgct attgatgaag 20
<210> 320
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 320
tctaagacga cgctctaatg 20
<210> 321
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 321
gctgctgttg accttctt 18
<210> 322
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 322
gacgctccat acgattgat 19
<210> 323
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 323
gtggctatga ccgttgaa 18
<210> 324
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 324
tgaccttaac cgagataacc 20
<210> 325
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 325
cgtcctggta tgtatattgg t 21
<210> 326
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 326
catcttcaac tcgtattact cc 22
<210> 327
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 327
gcgtaaccgt aagaacca 18
<210> 328
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 328
agtgcgatag agacctgat 19
<210> 329
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 329
gtatcggcgt ggaagtag 18
<210> 330
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 330
agttcgttca tctgctgtt 19
<210> 331
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 331
ggtggtgatt gaagatgct 19
<210> 332
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 332
ctgccgatgg aatgttga 18
<210> 333
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 333
cgtgatgaat ctgatgctaa g 21
<210> 334
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 334
agtgtaggag ttcggtgaa 19
<210> 335
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 335
ttcctgatgc tcgtgatg 18
<210> 336
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 336
ttctgactaa tgcctcgtat 20
<210> 337
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 337
acttcgtcct tctacctct 19
<210> 338
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 338
tcgttcacat ccacttcc 18
<210> 339
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 339
cgacagatat accaccacat a 21
<210> 340
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 340
ccatcactaa tagcgaccat 20
<210> 341
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 341
tgttggtgct tcagttgta 19
<210> 342
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 342
taatgctctt gacgctctt 19
<210> 343
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 343
gttggtgctt cagttgtaa 19
<210> 344
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 344
aatgctcttg acgctctt 18
<210> 345
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 345
gaccagtcgt tagaagttat tg 22
<210> 346
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 346
gatagcacca gcgttgtt 18
<210> 347
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 347
atcctctgtc ggcttcat 18
<210> 348
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 348
tgctcgctgt tattcactt 19
<210> 349
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 349
ggtcgttcgt caacatca 18
<210> 350
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 350
cttggtggag gtcaggaa 18
<210> 351
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 351
cattcttcac ttacgcttca 20
<210> 352
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 352
taatctcctc gcaatcttca 20
<210> 353
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 353
tgaacaagga ttcgtaagtg 20
<210> 354
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 354
ttgccaatgg atcacctaa 19
<210> 355
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 355
gacgaagaga atgcggata 19
<210> 356
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 356
ctgctacgaa cacaataagg 20
<210> 357
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 357
gacatcatcg gcatcaaga 19
<210> 358
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 358
tagaactgcg gacggtag 18
<210> 359
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 359
aggctcaggt ctacatcc 18
<210> 360
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 360
ggtcatctcg gtgttgtc 18
<210> 361
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 361
atcaccatca acacttctca 20
<210> 362
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 362
gctcttcgtc atcaacca 18
<210> 363
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 363
atcaccatca acacttctca 20
<210> 364
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 364
gctcttcgtc atcaacca 18
<210> 365
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 365
ttgaagcgac agtgacag 18
<210> 366
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 366
tacatctcca gcagaatagc 20
<210> 367
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 367
gtaccagcga tctgttcaa 19
<210> 368
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 368
ttacggcagg actttcttaa 20
<210> 369
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 369
tcgtccgaag agtgaaga 18
<210> 370
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 370
ccaactgatg taactgttcc 20
<210> 371
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 371
agcaagcgtt actggaag 18
<210> 372
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 372
tggcgaaata gcgaaaca 18
<210> 373
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 373
cgtaacagcg gcaatcag 18
<210> 374
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 374
tcttctccta agcggtcg 18
<210> 375
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 375
taccagtatc cgtaatagcg 20
<210> 376
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 376
gccaccagcg tatgaata 18
<210> 377
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 377
gcatcagcag ataattcaga c 21
<210> 378
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 378
tacaggcggt gacggtaa 18
<210> 379
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 379
ggaagttagc gttgaagaag 20
<210> 380
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 380
gcaggttgaa atggtgaaat 20
<210> 381
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 381
tgattgctga tggtgctaa 19
<210> 382
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 382
cttcttcgtc ttggttatgc 20
<210> 383
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 383
cgtatcgttc ctgtcgtaa 19
<210> 384
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 384
caccagacac atcgttga 18
<210> 385
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 385
ttcttcgttg gtcgtgtt 18
<210> 386
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 386
agccttcgta ttcgtagc 18
<210> 387
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 387
gagatccagg agtcattcaa 20
<210> 388
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 388
gagcaggttc acgaagaa 18
<210> 389
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 389
caaccaagga cttccacat 19
<210> 390
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 390
ggcaataccg accacatc 18
<210> 391
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 391
accaccactc cgaagaag 18
<210> 392
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 392
cttgacaccc tgcgtatc 18
<210> 393
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 393
aacagataca cgccactac 19
<210> 394
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 394
ccagcaacta caggaacat 19
<210> 395
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 395
cctgtcgttc atctcgtt 18
<210> 396
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 396
gcatcctcca atcccttg 18
<210> 397
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 397
tgtgatagac cagcagttc 19
<210> 398
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 398
cttagcattc ggagttcttc 20
<210> 399
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 399
gagaagaagc cacaggtt 18
<210> 400
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 400
cagaaggtag ccgtcatc 18
<210> 401
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 401
ggacaacaag tggacatca 19
<210> 402
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 402
attcaacaag cgacagaca 19
<210> 403
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 403
gtcggtggtg aacaagta 18
<210> 404
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 404
gaagtatcgc ctggaaca 18
<210> 405
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 405
gtaggcatcg agttgtga 18
<210> 406
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 406
acggtgaatg tcagtagc 18
<210> 407
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 407
gagttcgtca ccaagtgg 18
<210> 408
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 408
cgcattcatc aggtcgta 18
<210> 409
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 409
tctcctagaa ccgctactg 19
<210> 410
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 410
tgctccattt cgtcaactt 19
<210> 411
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 411
ttaggttgcg tattggaaga 20
<210> 412
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 412
aataagaagg ctggctctg 19
<210> 413
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 413
ggattgacga gcatattgac 20
<210> 414
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 414
gcgttggcga atgtaatc 18
<210> 415
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 415
tgttagtggt tgcgttgg 18
<210> 416
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 416
tgcggcgtaa tgtatctg 18
<210> 417
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 417
ttattcacgc tactggtcat 20
<210> 418
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 418
gttggcacat ctcttcaca 19
<210> 419
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 419
gccgacgata ttcatcttg 19
<210> 420
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 420
tgcgacctgt aattgtga 18
<210> 421
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 421
tattgccgtg attgcctt 18
<210> 422
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 422
gtccgttgat ggttcctt 18
<210> 423
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 423
ccgtcaaagt tattcaatcg 20
<210> 424
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 424
gcaagttcat tccatcctac 20
<210> 425
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 425
gccaatctca gccgaatt 18
<210> 426
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 426
ccacaatcca gtcagtagg 19
<210> 427
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 427
ctgctgctga agaccatt 18
<210> 428
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 428
gcgtcatcat caccaaca 18
<210> 429
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 429
atgaacagca cggtcaag 18
<210> 430
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 430
gtctccagaa gcgaagtc 18
<210> 431
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 431
ggtgttcaag acgctgtc 18
<210> 432
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 432
gatggagacc tcgcacaa 18
<210> 433
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 433
taatccattc taccgccatt 20
<210> 434
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 434
ccagcaccaa tagtcactt 19
<210> 435
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 435
ggtcttcata gcggtcaa 18
<210> 436
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 436
cttaggagca tcttgttcac 20
<210> 437
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 437
gtgatggcgt gattgtct 18
<210> 438
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 438
cgtgttgtcg taagtgttc 19
<210> 439
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 439
ggttatggtg gttattgtct g 21
<210> 440
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 440
aggcgagagt tgaagaatg 19
<210> 441
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 441
cagaatccgc cagaagaa 18
<210> 442
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 442
aacctccaat cgcaataatg 20
<210> 443
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 443
aaggcgatac cgtggaat 18
<210> 444
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 444
ctctgctcca gttggttg 18
<210> 445
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 445
gctgttctac tcgctgtt 18
<210> 446
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 446
atctgctcca tcaaggtg 18
<210> 447
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 447
ggaagcggac tactatctg 19
<210> 448
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 448
ggagcatcag cgaatctt 18
<210> 449
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 449
taagccagca ggtcagaa 18
<210> 450
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 450
atccatcgca gaactcatc 19
<210> 451
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 451
caactaccag cggcagaa 18
<210> 452
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 452
gaccttgacc ttcagcgta 19
<210> 453
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 453
ccgtgaagac cctgaaga 18
<210> 454
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 454
caactggttc tgctggtc 18
<210> 455
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 455
aatacaccga catcaccat 19
<210> 456
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 456
ttcttctgct ccgacttg 18
<210> 457
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 457
gcactatggc aagtatgtc 19
<210> 458
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 458
tagcggctgt tgttgtag 18
<210> 459
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 459
gcgagcagat tatcatcac 19
<210> 460
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 460
gcatagaggt tgttgagga 19
<210> 461
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 461
gctacttaca acgcagac 18
<210> 462
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 462
gccgatgact tccagatc 18
<210> 463
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 463
gacatctatc gccagtatta c 21
<210> 464
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 464
ccgtagccgt agttcttat 19
<210> 465
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 465
ggtgcctgaa ctcatcat 18
<210> 466
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 466
agtgcctcct tatagatagc 20
<210> 467
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 467
ccgtatctca agcatcgt 18
<210> 468
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 468
tccaggtgtt ccagaagt 18
<210> 469
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 469
ggcgttcagc agtcatta 18
<210> 470
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 470
cagcgtatcc agcacatt 18
<210> 471
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 471
tcgagaacat ccagaacag 19
<210> 472
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 472
acaagggaac cgataacg 18
<210> 473
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 473
atcgcatcgt gtccttct 18
<210> 474
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 474
gtcggcatag tccttcatc 19
<210> 475
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 475
acacttcatc cgcatcac 18
<210> 476
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 476
gaagccgaga tccagttg 18
<210> 477
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 477
aggtgctgat gatgaagg 18
<210> 478
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 478
cggttgaagt cgttgatg 18
<210> 479
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 479
agagtggtac gtccttcaa 19
<210> 480
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 480
agaggtatcg tcggtagc 18
<210> 481
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 481
cgcctggaag agatgaag 18
<210> 482
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 482
cgatgaacac cgcatact 18
<210> 483
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 483
cgatctccgt agtcttctc 19
<210> 484
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 484
actgtcgatc tggttgtc 18
<210> 485
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 485
agcctggact ggttctac 18
<210> 486
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 486
cttcttgacg atgccgat 18
<210> 487
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 487
ccaaagagga atcccagaaa 20
<210> 488
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 488
tcgcacttga ggtagagg 18
<210> 489
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 489
cgtctacagc cacttcac 18
<210> 490
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 490
cgatattcag caggacctt 19
<210> 491
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 491
ggtgcgatgt ctgagatta 19
<210> 492
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 492
caggatgatg aagcattgtt 20
<210> 493
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 493
caccacatac aatacctaca 20
<210> 494
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 494
ggaaaccaaa ctaccagatt 20
<210> 495
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 495
aacgcaggca cattatga 18
<210> 496
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 496
atctccttct ttccgcttt 19
<210> 497
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 497
cgtaacagaa ccaaccaatc 20
<210> 498
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 498
gaccaggatg atgaagcaa 19
<210> 499
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 499
tggcagcaag aatgtgat 18
<210> 500
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 500
gtgacaattc gttcggatc 19
<210> 501
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 501
cgctgaacgg cttactta 18
<210> 502
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 502
cggctcattc tcctgatg 18
<210> 503
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 503
ctgaagccta ttatgagaat gg 22
<210> 504
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 504
cactatgacc tccgtaacaa 20
<210> 505
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 505
cgaacctctt gtggcttat 19
<210> 506
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 506
tgttggaccg ttgtgtag 18
<210> 507
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 507
gacagccaag gaagaagaa 19
<210> 508
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 508
ccatacctca ctgaacaatt c 21
<210> 509
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 509
ttgttatgga cggtgaagg 19
<210> 510
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 510
actacgacgg atatgagaat c 21
<210> 511
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 511
tggatggagc aagaacaag 19
<210> 512
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 512
ggattggagc agcgttag 18
<210> 513
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 513
cttgaacttg ttggtgtagg 20
<210> 514
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 514
ggtcttactg aacggatgt 19
<210> 515
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 515
ggattggcta tgatgtgttg 20
<210> 516
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 516
ggtgtagatt gcgactgat 19
<210> 517
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 517
ggattacacg cttgattgaa 20
<210> 518
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 518
acttgccttg aactactgat 20
<210> 519
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 519
acccagtaca tggaggag 18
<210> 520
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 520
gatggaggac agcgtgat 18
<210> 521
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 521
gctcggtgtc gttgatac 18
<210> 522
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 522
taatgattgt tcggcggata 20
<210> 523
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 523
gccagcaacc tcattact 18
<210> 524
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 524
gcagccaaga cactatca 18
<210> 525
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 525
tcgtgaatcg gatggaga 18
<210> 526
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 526
gcttggtagt ctacttggtt 20
<210> 527
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 527
ggaagcagcg attgaaga 18
<210> 528
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 528
ctaccatcta gccactcatc 20
<210> 529
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 529
ttcggctcgt tcatctatc 19
<210> 530
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 530
aatcagtgtt gtggcatca 19
<210> 531
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 531
gttaggagaa gaggcaagg 19
<210> 532
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 532
agcattaggt aatccataga gg 22
<210> 533
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 533
atcgccacat agtcaagag 19
<210> 534
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 534
gatagacaag atacgccatt c 21
<210> 535
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 535
aatgctgctc tgcctatc 18
<210> 536
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 536
caataatcgt ggtgccttc 19
<210> 537
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 537
gaattgaagc aggcacatt 19
<210> 538
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 538
taccatcagc aactaatcca 20
<210> 539
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 539
gtcaccacta ttcacaatgc 20
<210> 540
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 540
cggatcatct cttcaacga 19
<210> 541
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 541
agtcgtgtcg ctattctac 19
<210> 542
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 542
gcatctcggt attctcaatc 20
<210> 543
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 543
ctcggattat gtagcaggaa 20
<210> 544
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 544
ggatcattgt catactcttg g 21
<210> 545
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 545
gtgctgttat aggtcgttat c 21
<210> 546
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 546
gttgccttgt cctgtaatac 20
<210> 547
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 547
ctgctgttat ttgctgtttg 20
<210> 548
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 548
atccgtgttc tgcctatc 18
<210> 549
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 549
acaagcacaa cgaacaga 18
<210> 550
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 550
ccgacaccat catcaaca 18
<210> 551
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 551
aacggtaaga ttggctatga 20
<210> 552
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 552
ttatgcgtca cttcaggtt 19
<210> 553
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 553
agcagtctaa ccgtagtct 19
<210> 554
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 554
tccttaccac cgccataa 18
<210> 555
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 555
gtatcaggca ctcggttg 18
<210> 556
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 556
cattcagcac agcataagc 19
<210> 557
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 557
ctattggcat tgtgtctgtc 20
<210> 558
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 558
taacggcttc gcttcatc 18
<210> 559
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 559
gaggattcag gtcggaag 18
<210> 560
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 560
gaacaggtac aaggcgata 19
<210> 561
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 561
gcctcattgg aacgctat 18
<210> 562
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 562
acggtgtctt gtggattc 18
<210> 563
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 563
tcggatttgt tcagtgagat 20
<210> 564
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 564
attcgttagt ggcaggatta 20
<210> 565
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 565
ttcttggcga gatgacttat 20
<210> 566
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 566
acctacttca ccgaatacg 19
<210> 567
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 567
ttcggtaagt taggcgtatt 20
<210> 568
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 568
cgttcttcag catcatcag 19
<210> 569
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 569
acaatcgtat ctcgtggac 19
<210> 570
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 570
gctcataggc agtcattcc 19
<210> 571
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 571
ttggtgttgc gattactga 19
<210> 572
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 572
gcgatacgat gcgactta 18
<210> 573
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 573
taacttacct tcagcgagag 20
<210> 574
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 574
agcaatcaac tcagactcat 20
<210> 575
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 575
tctggttgtc gtggtgtt 18
<210> 576
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 576
acgggataaa ctggttaatg g 21
<210> 577
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 577
ggttagttcc ttccgttgt 19
<210> 578
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 578
ccatacagcg taagcaatac 20
<210> 579
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 579
ctcgttcgtc gttcattc 18
<210> 580
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 580
gctaataagg cgttcaactt 20
<210> 581
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 581
gaagatgaac aggctattcg 20
<210> 582
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 582
acggcttact cagataatca 20
<210> 583
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 583
gtatcaggca ctcggttg 18
<210> 584
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 584
cattcagcac agcataagc 19
<210> 585
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 585
acatcaaggt cgctatcaa 19
<210> 586
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 586
ttaggcttca tcacaatctg 20
<210> 587
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 587
cacatcaagg tcgctatca 19
<210> 588
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 588
gcactcagca cagcataa 18
<210> 589
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 589
acaccgattg accaagtta 19
<210> 590
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 590
ttgtctgtat tcaccgattg 20
<210> 591
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 591
acaccgattg accaagtta 19
<210> 592
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 592
ttgtctgtat tcaccgattg 20
<210> 593
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 593
ccagtatcct taacaacctt g 21
<210> 594
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 594
gcatcaccag tccaatct 18
<210> 595
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 595
ttgacgatac gcctggta 18
<210> 596
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 596
cggatatttc tgtgggttga 20
<210> 597
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 597
acaccgattg accaagtta 19
<210> 598
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 598
ttgtctgtat tcaccgattg 20
<210> 599
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 599
caacttgcta cttatacgag tg 22
<210> 600
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 600
tggtgccgac ttgataga 18
<210> 601
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 601
atggtctaca atccgttcaa 20
<210> 602
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 602
ctggtatatg tcgcaagttg 20
<210> 603
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 603
ctatcaagtc ggcaccat 18
<210> 604
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 604
cattcaacac ggcatacg 18
<210> 605
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 605
atatgatgtg cctggtatgg 20
<210> 606
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 606
acttggtcaa tcggtgtatt 20
<210> 607
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 607
gttgtggcat tgtctatgaa 20
<210> 608
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 608
gtggaacatc ttaactgaag g 21
<210> 609
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 609
tatgcggaca atacaccaa 19
<210> 610
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 610
gttgcgagtt gaagtaagtt 20
<210> 611
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 611
cctacctgat atgctgagtt 20
<210> 612
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 612
aaccaagtgc ctgatacat 19
<210> 613
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 613
taatgccaac ctcaacaca 19
<210> 614
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 614
ctgccttaat gcgttcttc 19
<210> 615
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 615
gtatcaggca ctcggttg 18
<210> 616
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 616
cattcagcac agcataagc 19
<210> 617
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 617
taccgaagaa ccagatgc 18
<210> 618
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 618
ggaatgaaca cgacataagt 20
<210> 619
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 619
acaccgattg accaagtta 19
<210> 620
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 620
ttgtctgtat tcaccgattg 20
<210> 621
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 621
cacgatgtat caggcactt 19
<210> 622
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 622
gcattcagca ccgcatat 18
<210> 623
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 623
gtatcaggca ctcggttg 18
<210> 624
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 624
atccagcaca gcataagc 18
<210> 625
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 625
ttgacgatac gcctggta 18
<210> 626
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 626
tgtctggatt caccgattg 19
<210> 627
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 627
ggctatgcgg cttactatt 19
<210> 628
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 628
tccacactga cacaatgc 18
<210> 629
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 629
ctcggttagc ctgttcct 18
<210> 630
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 630
cacttggtca tatcggtaga t 21
<210> 631
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 631
cgattatgct ctccgttca 19
<210> 632
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 632
ctttcaccgc cattcctt 18
<210> 633
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 633
cctcttcggc aatacctatt 20
<210> 634
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 634
ttgacgggcg gatatttg 18
<210> 635
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 635
ctgctggtag tggaagac 18
<210> 636
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 636
ggatgcggta ttcgtagg 18
<210> 637
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 637
ggctatatct acgaccagaa t 21
<210> 638
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 638
cgaacacgaa gaactcct 18
<210> 639
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 639
tagtatcggc accaatgatt 20
<210> 640
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 640
gctaacacct tcgcatct 18
<210> 641
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 641
tccaacaggt ctacagtcta 20
<210> 642
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 642
attcgtcaag cagcagtat 19
<210> 643
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 643
tactcactgc tatcgtcaat 20
<210> 644
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 644
gccataatac ctccaccaa 19
<210> 645
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 645
gcgtatctat tcggtgact 19
<210> 646
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 646
catctgtcca tccacttaat g 21
<210> 647
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 647
gtggaaggtg gaagtgaat 19
<210> 648
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 648
cgctcgtcgt ataacagat 19
<210> 649
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 649
gaggaatctt acaacggatg 20
<210> 650
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 650
caacacggtc ataacttctt 20
<210> 651
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 651
agtatgtatg gctgttggtt 20
<210> 652
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 652
tcattgtagg cggtgtatc 19
<210> 653
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 653
ggcatacgac gaactaca 18
<210> 654
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 654
cagaagagca ggaagacat 19
<210> 655
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 655
gctaaggtgc tggtgaag 18
<210> 656
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 656
acgaggttgg tatggacta 19
<210> 657
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 657
tcaccaacac gccgaata 18
<210> 658
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 658
acataagacg agccgagat 19
<210> 659
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 659
cgtgtggtag gtgatgtaa 19
<210> 660
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 660
gtgtggtgga atgttggt 18
<210> 661
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 661
cttctgcctg ttcatcact 19
<210> 662
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 662
cttctgcctg ttcatcact 19
<210> 663
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 663
acaccatcct ctgcttct 18
<210> 664
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 664
acgccttctt catactcac 19
<210> 665
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 665
atgcgttatg tgctgataga 20
<210> 666
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 666
gttgatggtg tcggtgag 18
<210> 667
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 667
attgcggaat tgctgttg 18
<210> 668
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 668
attgtgcgac ggaatctc 18
<210> 669
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 669
gcttatgatt acgccctga 19
<210> 670
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 670
ggtccaatcc acgatgtc 18
<210> 671
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 671
tatcgttgcc atcactatca 20
<210> 672
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 672
tactgcttct cctgtctct 19
<210> 673
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 673
gcaaaggtca ggaaggtt 18
<210> 674
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 674
attcagccgt tcgttcaa 18
<210> 675
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 675
ccgttctctt accgttacc 19
<210> 676
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 676
ccgttcagca ggatgttc 18
<210> 677
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 677
gtcggcaatg tctggtta 18
<210> 678
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 678
tgttcttcgt atggctgata 20
<210> 679
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 679
gcgttacaca atgcgttat 19
<210> 680
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 680
aacatcactg gcgtcataa 19
<210> 681
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 681
gtcgcatatt caggaggaa 19
<210> 682
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 682
caccagcaac cacatagta 19
<210> 683
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 683
tactgttgtg cgtgaagg 18
<210> 684
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 684
agagatggaa gaggctgaa 19
<210> 685
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 685
agcggattct ggatactca 19
<210> 686
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 686
atatggtggc gatactcttg 20
<210> 687
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 687
cttgtgttag gcgtgagta 19
<210> 688
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 688
gttcttgagt attcgtgtag g 21
<210> 689
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 689
ccatcttctc acataacaag g 21
<210> 690
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 690
atcaataagc cgacaccaa 19
<210> 691
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 691
aacgcacctt cattgttg 18
<210> 692
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 692
cgatggtaat gcctgaca 18
<210> 693
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 693
ttggacgacg ataatgatgt 20
<210> 694
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 694
atctttcaac ctgccgatt 19
<210> 695
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 695
ttcctgtctc cgttaatcg 19
<210> 696
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 696
cgttgccaat atccatatcg 20
<210> 697
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 697
ggaatagcga gcgttatg 18
<210> 698
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 698
cctcattgta agcgtctaag 20
<210> 699
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 699
accgtaactc cgacttct 18
<210> 700
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 700
ccgcatagat gttgttagc 19
<210> 701
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 701
ttcgcatact ctaactccaa 20
<210> 702
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 702
tattgtcgtc cagcaggt 18
<210> 703
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 703
aaccttccta agcagattca 20
<210> 704
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 704
tagcgttgtt cctactgac 19
<210> 705
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 705
tctgacggat tcggctta 18
<210> 706
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 706
cataacggta ggcttcttga 20
<210> 707
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 707
aggattggca agattacga 19
<210> 708
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 708
ggtataggcg aacaggtt 18
<210> 709
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 709
gcgtctgtat cgtggtat 18
<210> 710
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 710
cttgctctcg gtatcctc 18
<210> 711
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 711
attgcttccg aggtcaga 18
<210> 712
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 712
gtccatatct ccgcttacaa 20
<210> 713
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 713
ttcctgctaa cgactcct 18
<210> 714
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 714
cgcctaacca ttcattcatt 20
<210> 715
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 715
tggactacaa ccgacact 18
<210> 716
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 716
ctgccttctt caacaatctg 20
<210> 717
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 717
ctatcgcttc ttggacctt 19
<210> 718
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 718
aactggctta ccttcttcat 20
<210> 719
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 719
tagcgagcga actgaatg 18
<210> 720
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 720
gtaagcacga atcacatacg 20
<210> 721
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 721
gttcctgtga tgattctatg g 21
<210> 722
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 722
attcctcgct cggtgtat 18
<210> 723
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 723
actatctcta cctcgccatc 20
<210> 724
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 724
ggagaacaac tggatcacc 19
<210> 725
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 725
gagtcggtat tgtcctgatt 20
<210> 726
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 726
ttaatgtggt gtgcttcgt 19
<210> 727
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 727
cggaagtcgg tattgtga 18
<210> 728
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 728
ataatgccac tgacctgag 19
<210> 729
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 729
ttagcggcat tatcctgaa 19
<210> 730
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 730
ggcggtatcg taatcctg 18
<210> 731
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 731
ggtcgttctg atgctctc 18
<210> 732
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 732
gtcgtatgtc gcctgatag 19
<210> 733
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 733
gctggatggt gactatgtt 19
<210> 734
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 734
taacggcttc gcaatgag 18
<210> 735
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 735
aagatgaaga gtggaacgat 20
<210> 736
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 736
cagaaccgat agtgataata cg 22
<210> 737
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 737
tgttgatcga cgatgacc 18
<210> 738
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 738
agttccagac cgaggatg 18
<210> 739
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 739
atgtccctga acactccg 18
<210> 740
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 740
tagaagtgct cgccgtag 18
<210> 741
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 741
gacgagcgac tcatcaag 18
<210> 742
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 742
aataccagga ataccagcag 20
<210> 743
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 743
gacgagcgac tcatcaag 18
<210> 744
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 744
aataccagga ataccagcag 20
<210> 745
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 745
gaagagtgta ttgaactgga ac 22
<210> 746
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 746
gagcgaagcg taaaggtt 18
<210> 747
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 747
cacggaagaa gccatcaa 18
<210> 748
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 748
ttcttgtact gcttgacctt 20
<210> 749
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 749
aattcaagga agccgaagg 19
<210> 750
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 750
gctgacactg aggttggt 18
<210> 751
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 751
ctggtcaagg tgctgttc 18
<210> 752
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 752
atctcggcgt tcttcagt 18
<210> 753
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 753
accagcaaca acctcaac 18
<210> 754
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 754
cgttcttgta ggcgatgat 19
<210> 755
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 755
cactacaacg ccgacaac 18
<210> 756
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 756
caggaagacc accaggat 18
<210> 757
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 757
gccgaactca aggaactg 18
<210> 758
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 758
ggtcatcagc aggaacatc 19
<210> 759
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 759
ggctacattc ctgacacaa 19
<210> 760
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 760
cgaagttcca taacgagaag 20
<210> 761
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 761
gacctaaccg acagcaat 18
<210> 762
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 762
cagcatcctc agagcaat 18
<210> 763
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 763
cgctgtagaa gtcaccatt 19
<210> 764
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 764
taccaaggca acgctatg 18
<210> 765
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 765
ccttcgctct cacagttc 18
<210> 766
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 766
cggcatcttc aatcgtatag 20
<210> 767
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 767
gtagcaggag aagacatagg 20
<210> 768
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 768
tggtatcaag gcgaaggt 18
<210> 769
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 769
tcggcgtcta catcttca 18
<210> 770
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 770
ctggtgatga tgatctcgtt 20
<210> 771
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 771
cgcatctcgt gaactgag 18
<210> 772
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 772
tcggtgagat cctccttc 18
<210> 773
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 773
tgatgtcggt atgcttgtc 19
<210> 774
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 774
gttggcttga atgtcgtatt 20
<210> 775
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 775
atgctgagtg gactgaatc 19
<210> 776
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 776
atcggcttcg ctaatactaa 20
<210> 777
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 777
ccactacgca ttcagcat 18
<210> 778
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 778
aacgcattcc agagtaagg 19
<210> 779
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 779
ttggcggttc tatcacttat 20
<210> 780
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 780
tcttcgtcgt cgtagttac 19
<210> 781
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 781
ggcaaggtag atggtctg 18
<210> 782
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 782
agttatccgc ataggtgtag 20
<210> 783
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 783
gtgccgacaa ctacgaag 18
<210> 784
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 784
tggttccagt gagtgctt 18
<210> 785
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 785
acagtcacat tcgcctatc 19
<210> 786
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 786
ctcatcgcca tcattacca 19
<210> 787
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 787
tcaacaacaa cggtcacat 19
<210> 788
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 788
tgcgaagaca cgaatagc 18
<210> 789
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 789
tggcttaggt ggtggtta 18
<210> 790
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 790
gtgctcttac ggtcatcc 18
<210> 791
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 791
gaaggctgga ccgatatg 18
<210> 792
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 792
cgaagaagtt gttgttacga 20
<210> 793
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 793
atagtgattg cggttattgc 20
<210> 794
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 794
tccatcgttc tccttcca 18
<210> 795
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 795
gcttctcgga tctgttca 18
<210> 796
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 796
tccagcatct ccaggtag 18
<210> 797
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 797
gccgcctgta tgaagaag 18
<210> 798
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 798
gcgagaagtt gacgtagat 19
<210> 799
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 799
ggtgttctgc gtgatgta 18
<210> 800
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 800
aactggcggt agatgttg 18
<210> 801
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 801
cgcaagacga aagaagaat 19
<210> 802
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 802
gcaggtagac attggaca 18
<210> 803
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 803
atgcgttctt ccagttct 18
<210> 804
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 804
cgtgattgtc gtagatgtg 19
<210> 805
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 805
gcaggttgag catctact 18
<210> 806
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 806
gtaggtcgcc acatactg 18
<210> 807
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 807
ccaggactta cagcaacta 19
<210> 808
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 808
tgttcaccat ctatcgctaa 20
<210> 809
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 809
gtgaggctgt tggagtaag 19
<210> 810
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 810
ggcaacgctt ctataatatc g 21
<210> 811
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 811
tgtatgccaa ctccagtatc 20
<210> 812
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 812
ttgccagtag cgagattg 18
<210> 813
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 813
gctatgaccg caagacag 18
<210> 814
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 814
gaggctggag gatgaagt 18
<210> 815
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 815
gcagcggcag tatgtatc 18
<210> 816
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 816
cagcgtgttg agaagagtat 20
<210> 817
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 817
ccgtgctaat gctcaaga 18
<210> 818
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 818
gtcgtaggtg ttaatcagtt c 21
<210> 819
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 819
tgttcatcag ccttgtgtt 19
<210> 820
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 820
catcagattc cgcagcat 18
<210> 821
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 821
acaccatcct ctgcttct 18
<210> 822
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 822
acgccttctt catactcac 19
<210> 823
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 823
ggtatcgccg taggtatg 18
<210> 824
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 824
ccagttccgc aatcttct 18
<210> 825
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 825
tctattccaa cccgagcat 19
<210> 826
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 826
cgccgacctt gtagtaac 18
<210> 827
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 827
tgaaaggaga accgcatta 19
<210> 828
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 828
cgagatagcc gaacagac 18
<210> 829
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 829
tgaaaggaga accgcatta 19
<210> 830
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 830
cgagatagcc gaacagac 18
<210> 831
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 831
ctggagatgg cgttatgg 18
<210> 832
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 832
gtgatgaggt cgtcgtatt 19
<210> 833
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 833
tggacatcta cggcttct 18
<210> 834
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 834
gaggcgaatg cgaataac 18
<210> 835
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 835
gacaatactg cttcacaaga g 21
<210> 836
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 836
gctgctccat caacaaca 18
<210> 837
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 837
atcgcaggag aaccaatc 18
<210> 838
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 838
atagccgcag atagacaag 19
<210> 839
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 839
gtgagtcgcc tggataga 18
<210> 840
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 840
agtcgcctgt gttattgc 18
<210> 841
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 841
tgcggtgtta gttgatgtt 19
<210> 842
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 842
ctcgttgaag tgcggtta 18
<210> 843
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 843
gctctttgtc atcgcattt 19
<210> 844
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 844
cgccaaggta agtcagaat 19
<210> 845
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 845
ggttgactac gcctatgg 18
<210> 846
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 846
cgagcctgtc ttgttgta 18
<210> 847
<211> 18
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 847
cgacaagcag gtgaagag 18
<210> 848
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 848
atgaagaaga acgggaagg 19
<210> 849
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 849
cgatgattcc ttggattgat 20
<210> 850
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 850
cacatactgc atgatgaact 20
<210> 851
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 851
acaccatacc gatttcaatg 20
<210> 852
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 852
gtaaccatca catacagcat 20
<210> 853
<211> 21
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 853
ccgatttcaa tgattccttg g 21
<210> 854
<211> 22
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 854
ggtaaccatc acatacagaa tg 22
<210> 855
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 855
tgatgccgtg ctatacaat 19
<210> 856
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 856
cattcttcgt cacctccat 19
<210> 857
<211> 20
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 857
tgatgataga gcaggagatt 20
<210> 858
<211> 19
<212> DNA
<213> Artificial Sequence (Artificial Sequence)
<400> 858
gccattcaac aacattagc 19
Claims (7)
1. An artificial intelligence antimicrobial drug dynamic monitoring device, comprising:
a gene measuring unit for measuring the number of drug-resistant genes;
and the analysis and judgment unit is used for obtaining the drug resistance degree of the corresponding antibacterial drugs based on the number of the drug resistance genes measured by the gene sequencing unit.
2. The artificial intelligence antimicrobial drug dynamics monitoring apparatus of claim 1,
the analysis determination unit further includes: and obtaining an antibiotic resistance enrichment result through hyper-geometric distribution calculation analysis according to the corresponding relation between different drug resistance genes and different antibiotics, and outputting an analysis result based on the antibiotic resistance enrichment result.
3. The device of claim 2, wherein the analysis results include recommended relevant antibiotics and medication adjustments.
4. The artificial intelligent antimicrobial drug dynamics monitoring apparatus of claim 2, wherein the determining the number of drug resistance genes comprises:
determining the number m of genes which can be determined from known drug-resistant genes in the sample,
obtaining a gene factor a contained in a certain antibiotic drug-resistant gene group in the quantity-increasing gene group;
the gene factor b contained in a certain antibiotic resistance gene group in the gene group with unchanged quantity;
a gene factor c excluding a in the population of elevated numbers;
the number of genes was unchanged except for the number d of genes in the population.
5. The artificial intelligent antimicrobial drug dynamics monitoring apparatus of claim 4, wherein the analysis unit comprises: the P value is calculated by using a formula (I),
and obtaining a drug resistance conclusion based on the comparison result of the P value and the preset value.
6. The device for dynamically monitoring artificial intelligence antibiotic drugs according to claim 5, wherein if the P value is less than 0.05, the drug resistance is considered.
7. The device for dynamically monitoring artificial intelligence antibiotic drugs according to claim 5, wherein the smaller the P value, the stronger the drug resistance is considered.
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