CN113952273A - Toothpaste containing yeast fermentation product extract composition and preparation method thereof - Google Patents
Toothpaste containing yeast fermentation product extract composition and preparation method thereof Download PDFInfo
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- CN113952273A CN113952273A CN202111116093.0A CN202111116093A CN113952273A CN 113952273 A CN113952273 A CN 113952273A CN 202111116093 A CN202111116093 A CN 202111116093A CN 113952273 A CN113952273 A CN 113952273A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention discloses a toothpaste containing yeast fermentation product extract and a preparation method thereof, wherein the paste of the toothpaste contains the yeast fermentation product extract or a composition containing the yeast fermentation product extract. The toothpaste containing the composition of the yeast fermentation product extract provided by the invention contains various nutritional ingredients and bioactive substances beneficial to oral health, and can be absorbed by oral mucosa in the process of tooth brushing to supplement nutrition, thereby achieving the effect of maintaining gum and oral health.
Description
Technical Field
The invention belongs to the technical field of daily chemical products, and particularly relates to toothpaste containing a composition of yeast fermentation product extracts and a preparation method of the toothpaste.
Background
Toothpaste is a common cleaning and nursing article in daily life and has a long history. With the continuous development of science and technology, the appearance of new raw materials and the continuous improvement and perfection of technological equipment, various types of toothpaste are brought out in succession, the quality and the grade of products are continuously improved, and the existing toothpaste varieties are changed from single clean toothpaste into functional toothpaste with complete varieties, various functions and hundreds of brands, so that the requirements of consumption levels of different levels are met. Nutritious health toothpastes containing bioactive ingredients have also been proposed in succession (e.g., probiotic toothpastes) and are gradually perceived and accepted by consumers.
The yeast is utilized by human for a long time and is used for food processing, but the yeast fermentation product extract has the recent discovery of the nutrition and health care effect on human skin and is successfully applied to high-grade skin care cosmetics. The yeast fermentation product extract contains rich nutrients and bioactive substances, such as protein, polypeptide, amino acids, nucleic acid, nucleotide, vitamins, minerals, etc. Has effects of delaying skin aging, promoting cell metabolism, keeping moisture, improving xerosis cutis, whitening skin and removing speckle. Can be used for preparing cosmetic with skin caring, skin whitening and moisture keeping effects.
At present, the composition of the yeast fermentation product extract has a fresh application in toothpaste, and the application aims to provide the composition of the yeast fermentation product extract for toothpaste.
Disclosure of Invention
The present invention has been made keeping in mind the above problems occurring in the prior art, and an object of the present invention is to provide toothpaste containing a composition extracted from yeast fermentation products and a method for preparing the same.
The invention solves the technical problems through the following technical means:
the toothpaste containing the composition of the yeast fermentation product extract comprises:
at least one of a small molecule peptide and a hydrolyzed plant protein;
or at least one amino acid;
or at least one of dipotassium glycyrrhizinate and plant extract;
or at least one vitamin.
Further, the amino acid includes glutamic acid, serine, arginine, glycine, threonine, tyrosine, lysine, alanine, aspartic acid, isoleucine, histidine, leucine, methionine, phenylalanine, cystine.
Further, the small molecule peptide is silk peptide, and the hydrolyzed vegetable protein comprises hydrolyzed wheat protein and hydrolyzed soybean protein.
Further, the vitamins include sodium ascorbyl phosphate, tocopheryl acetate, niacinamide, D-panthenol.
Further, the plant extract includes honeysuckle extract, dandelion extract, peony root extract, aloe extract, chamomile extract, chlorophyll.
The invention also provides a preparation method of the toothpaste containing the yeast fermentation product extract, which comprises the following steps:
the first step is as follows: accurately weighing all raw materials in the formula;
the second step is that: the adhesive, the foaming agent (powder) and the abrasive are stirred and mixed uniformly in advance;
the third step: dissolving water soluble materials such as sweetener and stabilizer (sodium pyrophosphate) in water;
the fourth step: adding water solutions such as humectant, sweetener, etc., nutrient substances such as yeast fermentation product extract, etc., and water into a vacuum paste making pot, starting stirring, and uniformly stirring the liquid raw materials;
the fifth step: sucking mixed powder such as abrasive under vacuum and high-speed stirring (homogenizing), stirring to obtain paste, sucking liquid foaming agent, and homogenizing under vacuum for a proper time;
and a sixth step: absorbing essence, continuing vacuum homogenizing for a proper time (the total homogenizing time is controlled to be 30-40 minutes), and finally vacuumizing to enable the vacuum degree to reach the technological requirement (below-0.096 MPa) and continuing for a proper time;
the seventh step: the stirring was stopped and the vacuum broken. And (4) after the normal pressure is recovered, sampling the paste, detecting the qualified paste (items such as appearance, fragrance, paste specific gravity, consistency or viscosity, pH value, foam amount and the like), and discharging for later use.
The invention has the beneficial effects that: the toothpaste containing the composition of the yeast fermentation product extract provided by the invention contains various nutritional ingredients and bioactive substances beneficial to oral health, and can be absorbed by oral mucosa in the process of tooth brushing to supplement nutrition, thereby achieving the effect of maintaining gum and oral health.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
This example provides a toothpaste containing a composition of yeast fermentation product extract, the toothpaste comprising:
yeast fermentation product extract, yeast fermentation product extract stock solution adding amount (by stock solution containing protein 1.5%): 0.05-20% of non-transparent paste and 0.05-10% of transparent paste;
the yeast fermentation product extract and small molecular peptide or hydrolyzed plant protein, wherein the small molecular peptide can be fibroin, the hydrolyzed plant protein can be hydrolyzed wheat protein and hydrolyzed soybean protein, and the addition amount of the stock solution of the fibroin peptide (average molecular weight 500-: 0.1-10% (0.1-6% transparent toothpaste), and the addition amount of the hydrolyzed vegetable protein stock solution is as follows: 0-10% (transparent toothpaste 0-6%);
the yeast fermentation product extract and/or various amino acids are glutamic acid, serine, arginine, glycine, threonine, tyrosine, lysine, alanine, aspartic acid, isoleucine, histidine, leucine, methionine, phenylalanine and cystine, and the addition amount of the amino acids is implemented according to relevant regulations in GB 2760;
yeast fermentation product extract and dipotassium glycyrrhizinate or plant extract, wherein the plant extract comprises honeysuckle extract, dandelion extract, peony root extract, aloe extract, chamomile extract and chlorophyll, and the adding amount of the plant extract (stock solution) is as follows: 0-10% (transparent toothpaste 0-6%);
yeast fermentation product extract and/or vitamins, wherein the vitamins comprise sodium ascorbyl phosphate, tocopherol acetate, nicotinamide, D-panthenol, and the addition amount of the sodium ascorbyl phosphate is as follows: 0.05-0.5%, and the addition amount of vitamin E (tocopheryl acetate): 0.05-0.5%, the addition amount of D-panthenol is 0-0.2%, the addition amount of nicotinamide is 0-2%, and the addition amounts of other vitamins are performed according to relevant regulations in GB 2760.
The yeast fermentation product extract comprises at least one of yeast lysate extract, yeast fermentation product filtrate, and yeast secondary fission yeast fermentation product lysate extract.
Besides the yeast fermentation product extract and the composition thereof, the toothpaste also contains the following components: humectant, adhesive, foaming agent, abrasive, sweetener, functional component, stabilizer, essence and water.
The humectant mainly comprises sorbitol (70%), PEG-400, glycerol, propylene glycol, etc. The dosage of the humectant in the toothpaste is as follows: 0-30% of glycerin, 0-6% of PEG-400, 20-70% of sorbitol and 0-20% of propylene glycol.
The foaming agent mainly comprises sodium lauryl sulfate (K12, 94%), sodium lauroyl sarcosinate (S12, 30%), cocamidopropyl betaine (CAB, 30%), disodium lauroyl glutamate (30%), sodium methyl cocoyl taurate (30%) and the like. The dosage of the formula is 1-3% based on the active matter dry agent. The sodium lauryl sulfate can be used alone or in combination with other foaming agents; or other foaming agents are compounded for use.
The adhesive mainly comprises sodium carboxymethylcellulose (CMC, cellulose gum), hydroxyethyl cellulose (HEC), xanthan gum, carrageenan and hydroxypropyl guar gum. CMC can be used alone, can also be used together with xanthan gum, etc.; or other adhesives are compounded for use.
The abradant mainly comprises two types of silicon dioxide and calcium carbonate:
silicon dioxide: the thickening type friction type.
The calcium carbonate can be used independently, and can also be used after being compounded with thickening silica or comprehensive silica.
The dosage of the preservative is strictly in accordance with the relevant regulations in GB22115 raw material Standard for toothpaste.
The specific contents of the components of the toothpaste in the example are shown in Table 1 (Table 1: toothpaste formula composition table):
in the embodiment, correspondingly disclosed are test examples 1-7:
the toothpaste containing the composition of the yeast fermentation product extract provided by the invention contains various nutritional ingredients and bioactive substances beneficial to oral health, and can be absorbed by oral mucosa in the process of tooth brushing to supplement nutrition, thereby achieving the effect of maintaining gum and oral health. The yeast fermentation product extract contains various nutrients and bioactive substances such as protein, polypeptide, amino acids, nucleosides, nucleotides, minerals and trace elements, vitamin B group, active enzyme, sterol, immune polysaccharide, etc. The nutrient substances and the bioactive substances can be directly utilized basically, so that the oral epidermal cells are fully nourished, and the healthy and active epidermal cells are helped. Thereby maintaining gum and oral health.
In addition, the yeast fermentation product extract can also be combined with other functional components in the toothpaste:
combining the yeast fermentation product extract with anticariogenic components (such as sodium fluoride, sodium monofluorophosphate, stannous fluoride, fluoride calculated by fluoride ion, 0.05-0.15%);
the yeast fermentation product extract and anti-allergic components (such as potassium nitrate 0.1-8%, strontium chloride hexahydrate 0.05-0.6%) are combined;
the yeast fermentation product extract and baking soda (sodium bicarbonate, 0.05-8%) are combined.
Example 2
The embodiment discloses a first toothpaste making process:
the first step is as follows: accurately weighing all raw materials in the formula;
the second step is that: the adhesive, the foaming agent (powder) and the abrasive are stirred and mixed uniformly in advance;
the third step: dissolving water soluble materials such as sweetener and stabilizer (sodium pyrophosphate) in water;
the fourth step: adding water solutions such as humectant, sweetener, etc., nutrient substances such as yeast fermentation product extract, etc., and water into a vacuum paste making pot, starting stirring, and uniformly stirring the liquid raw materials;
the fifth step: sucking mixed powder such as abrasive under vacuum and high-speed stirring (homogenizing), stirring to obtain paste, sucking liquid foaming agent, and homogenizing under vacuum for a proper time;
and a sixth step: absorbing essence, continuing vacuum homogenizing for a proper time (the total homogenizing time is controlled to be 30-40 minutes), and finally vacuumizing to enable the vacuum degree to reach the technological requirement (below-0.096 MPa) and continuing for a proper time;
the seventh step: the stirring was stopped and the vacuum broken. And (4) after the normal pressure is recovered, sampling the paste, detecting the qualified paste (items such as appearance, fragrance, paste specific gravity, consistency or viscosity, pH value, foam amount and the like), and discharging for later use.
And a second toothpaste making process:
s1: accurately weighing all raw materials in the formula;
s2: the foaming agent (powder) and the abrasive agent are stirred and mixed evenly in advance,
s3: dissolving water soluble materials such as sweetener and stabilizer (sodium pyrophosphate) in water,
s4-1: adding water solution such as humectant (sorbitol), sweetener, etc., nutrient substances such as yeast fermentation product extract, etc., and water into vacuum paste making pot, starting stirring, and stirring liquid raw materials uniformly;
s4-2: adding humectant (glycerol or propylene glycol) into the other liquid material premixing pot, stirring, adding adhesive, and dispersing the adhesive into uniform slurry;
s4-3: starting vacuum and stirring in a vacuum paste making pot, sucking in adhesive slurry (reserving a part of humectant such as sorbitol, adding into a liquid material premixing pot, stirring, adding the rest adhesive slurry into the humectant, sucking into the vacuum paste making pot together), and stirring and mixing with the liquid material to obtain uniform glue;
s5: sucking mixed powder such as abradant and the like under vacuum and high-speed stirring (homogenizing), stirring into paste, and sucking liquid foaming agent. Homogenizing under vacuum for a suitable time;
s6: absorbing essence, continuing vacuum homogenizing for a proper time (the total homogenizing time is controlled to be 30-40 minutes), and finally vacuumizing to enable the vacuum degree to reach the technological requirement (below-0.096 MPa) and continuing for a proper time;
s7: stopping stirring, breaking vacuum, recovering normal pressure, sampling paste, detecting to obtain qualified paste (appearance, fragrance, paste specific gravity, consistency or viscosity, pH value, foam amount, etc.), and discharging.
The embodiment also provides a method for coating the yeast fermentation product extract or the composition containing the yeast fermentation product extract into microcapsules, which comprises the following steps:
1) preparing yeast fermentation product extract or composition containing yeast fermentation product extract into suspension as core material;
2) dissolving sodium carboxymethylcellulose in deionized water, removing insoluble substances, and adjusting pH to weak acidity, such as pH 5, to obtain sodium carboxymethylcellulose solution;
3) and mixing the sodium carboxymethyl cellulose solution with the core material suspension, then mechanically stirring for 30min, carrying out solid-liquid separation to obtain a solid, and washing off the non-adsorbed sodium carboxymethyl cellulose in the obtained solid by using deionized water, thereby obtaining the sodium carboxymethyl cellulose microcapsule.
The coating of the yeast fermentation product extract or the composition containing the yeast fermentation product extract based on sodium carboxymethyl cellulose according to this example had the following effects compared to directly adding the yeast fermentation product extract or the composition containing the yeast fermentation product extract to the toothpaste mixture: the capsule wall of the microcapsule wraps the yeast fermentation product extract or the yeast fermentation product extract to a certain degree, and provides an isolation environment, so that the yeast fermentation product extract or the yeast fermentation product extract is prevented from being exposed to an external environment, and the breeding of bacteria and the oral health problem caused by the breeding of bacteria are avoided; the toothpaste body can be added with abrasive, such as silicon dioxide and calcium carbonate, when brushing teeth, the carboxymethylcellulose sodium microcapsule can be broken under the abrasive action of the abrasive, so that yeast fermentation product extract or composition containing yeast fermentation product extract contained in the carboxymethylcellulose sodium microcapsule can be exposed and absorbed in oral cavity; based on the addition of the carboxymethylcellulose sodium microcapsule, after the carboxymethylcellulose sodium microcapsule is broken, the carboxymethylcellulose sodium serving as the capsule wall can also help the yeast fermentation product extract or the composition containing the yeast fermentation product extract to be adhered to the oral mucosa so as to improve the retention time of the yeast fermentation product extract or the composition containing the yeast fermentation product extract on the oral mucosa and further improve the absorption efficiency.
It is noted that, in this document, relational terms such as first and second, and the like, if any, are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (10)
1. The toothpaste containing the yeast fermentation product extract is characterized in that the paste of the toothpaste contains the yeast fermentation product extract or a composition containing the yeast fermentation product extract.
2. The toothpaste containing yeast fermentation product extract according to claim 1, wherein the composition comprises, in addition to yeast fermentation product extract:
at least one of a small molecule peptide and a hydrolyzed plant protein;
or at least one amino acid;
or at least one of dipotassium glycyrrhizinate and plant extract;
or at least one vitamin.
3. The toothpaste containing yeast fermentation product extract according to claim 2, wherein the amino acids comprise glutamic acid, serine, arginine, glycine, threonine, tyrosine, lysine, alanine, aspartic acid, isoleucine, histidine, leucine, methionine, phenylalanine, cystine.
4. The toothpaste containing yeast fermentation product extract according to claim 2, wherein the small molecule peptide is silk peptide, and the hydrolyzed vegetable protein comprises hydrolyzed wheat protein and hydrolyzed soybean protein.
5. The toothpaste containing yeast fermentation product extract according to claim 2, wherein said vitamins include sodium ascorbyl phosphate, tocopheryl acetate, niacinamide, D-panthenol.
6. The toothpaste containing yeast fermentation product extract according to claim 2, wherein the plant extract comprises honeysuckle extract, dandelion extract, peony root extract, aloe extract, chamomile extract, chlorophyll.
7. The toothpaste containing yeast fermentation product extract according to claim 1, wherein the toothpaste body further contains at least one of an anticaries component and an anti-sensitivity component baking soda.
8. The toothpaste containing yeast fermentation product extract according to claim 7, wherein the anticaries component comprises sodium fluoride, sodium monofluorophosphate, stannous fluoride, and the anti-sensitivity component comprises potassium nitrate and strontium chloride hexahydrate.
9. The toothpaste containing the yeast fermentation product extract according to claim 1, wherein the yeast fermentation product extract or the composition containing the yeast fermentation product extract is coated with a protective agent to be microencapsulated and dispersed in a paste of the toothpaste.
10. A preparation method of toothpaste containing yeast fermentation product extract is characterized by comprising the following steps:
s1: accurately weighing all raw materials in the formula;
s2: the foaming agent and the abrasive agent are stirred and mixed evenly in advance,
s3: dissolving water soluble materials such as sweetener and stabilizer in water in advance,
s4-1: adding water solutions such as humectant, sweetener, etc., nutrient substances such as yeast fermentation product extract, etc., and water into a vacuum paste making pot, starting stirring, and uniformly stirring the liquid raw materials;
s4-2: adding a humectant into the other liquid material premixing pot, starting stirring, adding an adhesive, and dispersing the adhesive into uniform slurry;
s4-3: starting vacuum and stirring in a vacuum paste making pot, sucking the adhesive slurry, and uniformly stirring the adhesive slurry and the liquid material to form uniform glue;
s5: sucking mixed powder such as abrasive under vacuum and high-speed stirring, stirring to obtain paste, sucking liquid foaming agent, and homogenizing under vacuum;
s6: absorbing essence, continuing vacuum homogenization for 30-40 minutes, and finally vacuumizing to below-0.096 MPa;
s7: stopping stirring, breaking vacuum, recovering normal pressure, sampling paste, detecting, and discharging for use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111116093.0A CN113952273A (en) | 2021-09-23 | 2021-09-23 | Toothpaste containing yeast fermentation product extract composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111116093.0A CN113952273A (en) | 2021-09-23 | 2021-09-23 | Toothpaste containing yeast fermentation product extract composition and preparation method thereof |
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| CN114404318A (en) * | 2022-02-24 | 2022-04-29 | 浙江大学 | Toothpaste containing silk fibroin and preparation method thereof |
| CN114903854A (en) * | 2022-06-20 | 2022-08-16 | 广西丝蜜派科技有限公司 | Oral spray |
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| CN114903854A (en) * | 2022-06-20 | 2022-08-16 | 广西丝蜜派科技有限公司 | Oral spray |
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