CN113769200B - Hematopoietic stem cell reinfusion device - Google Patents
Hematopoietic stem cell reinfusion device Download PDFInfo
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- CN113769200B CN113769200B CN202111025642.3A CN202111025642A CN113769200B CN 113769200 B CN113769200 B CN 113769200B CN 202111025642 A CN202111025642 A CN 202111025642A CN 113769200 B CN113769200 B CN 113769200B
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- 210000003958 hematopoietic stem cell Anatomy 0.000 title claims abstract description 18
- 239000008280 blood Substances 0.000 claims abstract description 165
- 210000004369 blood Anatomy 0.000 claims abstract description 165
- 210000000130 stem cell Anatomy 0.000 claims abstract description 122
- 239000007788 liquid Substances 0.000 claims abstract description 84
- 238000000034 method Methods 0.000 claims abstract description 39
- 230000008569 process Effects 0.000 claims abstract description 39
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 32
- 239000011780 sodium chloride Substances 0.000 claims abstract description 27
- 238000011010 flushing procedure Methods 0.000 claims abstract description 20
- 238000001802 infusion Methods 0.000 claims abstract description 15
- 230000002457 bidirectional effect Effects 0.000 claims description 30
- 238000002156 mixing Methods 0.000 claims description 18
- 238000007789 sealing Methods 0.000 claims description 13
- 238000005286 illumination Methods 0.000 claims description 10
- 239000012267 brine Substances 0.000 claims description 5
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 claims description 5
- 238000009434 installation Methods 0.000 claims description 3
- 230000006835 compression Effects 0.000 claims description 2
- 238000007906 compression Methods 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 abstract description 3
- 208000035143 Bacterial infection Diseases 0.000 abstract description 3
- 208000022362 bacterial infectious disease Diseases 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 8
- 239000002504 physiological saline solution Substances 0.000 description 8
- 230000000712 assembly Effects 0.000 description 3
- 238000000429 assembly Methods 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
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- 210000001161 mammalian embryo Anatomy 0.000 description 1
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- 210000000056 organ Anatomy 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16804—Flow controllers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16804—Flow controllers
- A61M5/16827—Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16877—Adjusting flow; Devices for setting a flow rate
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- External Artificial Organs (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention relates to the technical field of stem cell reinfusion, and discloses a hematopoietic stem cell reinfusion device which comprises a telescopic bracket, a saline bag, a blood transfusion pipeline and a blood transfusion control system; the blood transfusion pipeline is used for respectively connecting the saline bag and the blood transfusion bag and transfusing blood to a human body; the infusion control system is used for controlling the flow direction of liquid in the blood transfusion pipeline, and is also used for providing the flow power of the liquid in the blood transfusion pipeline. The controller is used for controlling the reinfusion process of the stem cells in stages according to the real-time capacity of the stem cells in the blood transfusion bag, so that the reinfusion process of the stem cells is ensured to be input into a human body rapidly and completely in stages under the control of the controller, the problem of misoperation easily caused by manual work is solved through the intervention of automatic control, the accuracy of the blood transfusion process is ensured, bacteria in the process of continuously carrying out plugging and flushing by manual work are exposed through the intervention of automatic control, and the risk of bacterial infection in the blood transfusion process is reduced.
Description
Technical Field
The invention relates to the technical field of stem cell reinfusion, in particular to a hematopoietic stem cell reinfusion device.
Background
Stem cells, which are cells that have not been differentiated and are found in early embryo, bone marrow, umbilical cord, placenta, and part of adult cells, can be cultured into human tissues and organs such as muscle, bone, and nerve, and are of great importance in the treatment of many diseases.
In the stem cell reinfusion process, stem cells flow down along the tube wall in the reinfusion process because the stem cells are sticky, so that the stem cells are prevented from being detained on the tube wall in order to ensure the activity of the stem cells, physiological saline is usually required to be used for flushing blood transfusion tubes for many times in the stem cell reinfusion treatment process, a common physiological saline flushing strategy is to be used for flushing the blood transfusion tubes in a manner of plugging and flushing for many times or a manner of manually controlling the opening and closing flow direction of a valve is adopted for controlling the flushing of the physiological saline, but the process needs to be manually operated, and the problem of misoperation is easy to occur due to numerous valves, so that the normal reinfusion process of the stem cells is influenced.
And because the blood bag capacity of stem cells is smaller, when the stem cell content in the stem cell blood bag is less than half of the total blood bag capacity, the stem cells are viscous due to the reduction of the stem cell quantity, so that the pressure of stem cell conveying is insufficient, the flow velocity of the stem cells in the infusion tube is reduced, and the conveying speed of the stem cells is influenced.
For the problems in the related art, no effective solution has been proposed at present.
Disclosure of Invention
(one) solving the technical problems
Aiming at the defects of the prior art, the invention provides a hematopoietic stem cell reinfusion device which has the advantages of accurate and controllable blood transfusion process, low probability of stem cell pollution, good blood transfusion effect and the like, and solves the problems of misoperation easily caused by complex flow in the stem cell reinfusion process and lower pressure shortage and conveying speed in the stem cell reinfusion process.
(II) technical scheme
In order to solve the technical problems that the flow is complex and misoperation is easy to occur in the stem cell reinfusion process, and the pressure is insufficient and the conveying speed is low in the stem cell reinfusion process, the invention provides the following technical scheme: a hematopoietic stem cell reinfusion device comprising a telescoping scaffold, further comprising: saline bag, blood transfusion line and blood transfusion control system; the saline bag and the blood transfusion bag are respectively mounted on the telescopic bracket, and the mounting height of the saline bag is higher than that of the blood transfusion bag; the blood transfusion pipeline comprises a long liquid inlet pipe, a short liquid inlet pipe and a liquid delivery pipe, and the long liquid inlet pipe, the short liquid inlet pipe and the liquid delivery pipe are connected through a liquid mixing tee joint; the blood transfusion pipeline is used for connecting the saline bag and the blood transfusion bag through the long liquid inlet pipe and the short liquid inlet pipe respectively, and the blood transfusion pipeline is used for blood transfusion to a human body through the blood transfusion pipe; the blood transfusion control system comprises a controller, a bidirectional pressure supply device, a stem cell capacity detector and a plurality of clamping valves; the infusion control system is used for controlling the flow direction of liquid in the blood transfusion pipeline, and the infusion control system is also used for providing the flow power of the liquid in the blood transfusion pipeline.
Preferably, the stem cell volume detector is mounted on the outer side of the blood transfusion bag, and comprises a light emitter and a light receiver, wherein the light emitter emits light to pass through the blood transfusion bag and then is received by the light receiver; the stem cell capacity detector transmits the illumination intensity of each height received by the light receiver to the controller, and the controller judges the stem cell capacity inside the blood transfusion bag according to the illumination intensity of each height.
Preferably, the plurality of clamping valves are respectively arranged at different positions of the blood transfusion pipeline, the plurality of clamping valves are divided into a brine valve, a blood transfusion valve, a liquid mixing valve, a check valve and a pressure supply valve according to the different installation positions, and the plurality of clamping valves are used for controlling the corresponding blood transfusion pipeline to be opened and closed; the saline valve and the blood transfusion valve are respectively arranged on the long liquid inlet pipe and the short liquid inlet pipe, the liquid mixing valve and the check valve are respectively arranged on two sides of a Murphy dropper of the infusion pipe from top to bottom, and the pressure supply valve is arranged on the outer side of the bidirectional pressure supply device; the clamping valves are respectively connected with the controller in a signal mode, and the controller controls the opening and closing of each clamping valve.
Preferably, the bidirectional pressure supply device comprises a bidirectional air inlet fan, a pressure-resistant cavity and a replaceable air bag; the pressure-resistant cavity of the bidirectional pressure supply device is provided with a side opening, and a shielding door is arranged outside the side opening and used for keeping the pressure-resistant cavity closed; the center of the shielding door is provided with a fixing opening which is used for fixing the replaceable air bag; the bidirectional air inlet fan is connected with the pressure-resistant cavity, and is used for controlling the pressure intensity inside the pressure-resistant cavity.
Preferably, the replaceable airbag is installed inside the pressure-resistant cavity, and a connection port of the replaceable airbag penetrates out of the pressure-resistant cavity through the fixed opening; a connecting tee joint is arranged between the liquid mixing valve and the check valve of the infusion tube; the replaceable air bag is communicated with the blood transfusion pipeline through a connecting pipe and the connecting tee joint; the pressure supply valve is arranged at one end of the connecting pipe close to the replaceable air bag.
Preferably, the controller divides the stem cell reinfusion process into a transfusion phase, a pressurization phase and a flushing phase according to the stem cell capacity in the transfusion bag detected by the stem cell capacity detector; in each of the blood transfusion stage, the pressurization stage and the flushing stage, the opening and closing conditions of a plurality of clamping valves in different stages are respectively controlled by a controller, and the two-way air inlet fan is controlled by the controller to provide different pressures for the pressure-resistant cavity in different stages.
Preferably, the clamping valve comprises an operating semi-ring and a fixing semi-ring, wherein one ends of the operating semi-ring and the fixing semi-ring are rotationally connected, and the other ends of the operating semi-ring and the fixing semi-ring are magnetically connected; the operation semi-ring and the fixing semi-ring form a ring shape, a clamping hoop is arranged in the ring shape formed by the operation semi-ring and the fixing semi-ring, and the clamping hoop is used for installing the clamping valve at the corresponding position of the blood transfusion pipeline.
Preferably, a sealing assembly is arranged in the center of the outer side of the operation semi-ring, and is used for pressing the blood transfusion pipeline at the corresponding position in a controlled manner to seal the corresponding position of the blood transfusion pipeline; the sealing assembly comprises an electric telescopic rod and a rubber push plate, wherein the fixed end of the electric telescopic rod is fixed with the inner wall of the operation semi-ring, the telescopic end of the electric telescopic rod penetrates into the annular part formed by the operation semi-ring and the fixing semi-ring, and the telescopic end of the electric telescopic rod is fixed with the rubber push plate; the electric telescopic rod is controlled by the controller to move, and the electric telescopic rod is used for pushing the rubber push plate to press and seal the corresponding position of the blood transfusion pipeline.
(III) beneficial effects
Compared with the prior art, the invention provides a hematopoietic stem cell reinfusion device, which has the following beneficial effects:
1. according to the hematopoietic stem cell reinfusion device, the controller is used for controlling the reinfusion process of stem cells in stages according to the real-time capacity of the stem cells in a blood transfusion bag, so that the reinfusion process of the stem cells can be fully controlled, the stem cells can be ensured to be rapidly and completely input into a human body in stages under the control of the controller, the problem of misoperation which is easy to occur manually is solved through the intervention of automatic control, the accuracy of the blood transfusion process is ensured, and bacteria in the process of continuously performing plugging and flushing by the manual intervention is exposed, so that the risk of bacterial infection in the blood transfusion process is reduced.
2. In the hematopoietic stem cell reinfusion device, when the real-time capacity of stem cells in a blood transfusion bag is smaller than two fifths of the total capacity of the blood transfusion bag and larger than one tenth of the total capacity of the blood transfusion bag in the stem cell reinfusion process, the stem cells in the blood transfusion bag are pumped into the replaceable air bag through the pressurizing conveying process of a pressurizing stage, then the stem cells are input into a human body from the replaceable air bag, the stem cells are pumped into the replaceable air bag through a bidirectional air inlet fan and a pressure-resistant cavity in the pressurizing stage, and the conveying power of the stem cells is input into the human body from the replaceable air bag, so that the viscous effect of the blood transfusion bag on the stem cells is fully dealt with, the conveying speed of the stem cells is fully maintained, and the activity of the stem cells is fully ensured in the rapid conveying process.
3. According to the hematopoietic stem cell reinfusion device, in the stem cell reinfusion process, when the real-time capacity of stem cells in a blood transfusion bag is less than one tenth of the total capacity of the blood transfusion bag, a flushing stage is carried out, the pressure-resistant cavity is controlled by the controller to repeatedly carry out positive and negative pressure circulation, so that physiological saline and a small amount of stem cells repeatedly flow through the blood transfusion bag, the short liquid inlet pipe, the liquid conveying pipe, the connecting pipe and the replaceable air bag, the blood transfusion bag, the short liquid inlet pipe, the liquid conveying pipe, the connecting pipe and the replaceable air bag are flushed, the stem cells can be completely input into a human body, the loss of the stem cells is reduced, and the blood transfusion effect is improved.
Drawings
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is a front view of the present invention;
FIG. 3 is an enlarged schematic view of portion A of FIG. 2 in accordance with the present invention;
FIG. 4 is an enlarged schematic view of portion B of FIG. 2 in accordance with the present invention;
FIG. 5 is a schematic view of a partial perspective structure of the present invention;
FIG. 6 is an exploded view of the bi-directional pressure supply device of the present invention;
FIG. 7 is a schematic perspective view of a pinch valve of the present invention;
FIG. 8 is a schematic view of the deployment pattern of the pinch valve of the present invention;
FIG. 9 is a schematic cross-sectional view of a pinch valve of the present invention;
FIG. 10 is a schematic diagram showing the perspective structure of a stem cell capacity detector according to the present invention.
In the figure: 1. a retractable stand; 2. a brine bag; 3. a blood transfusion bag; 4. a blood transfusion line; 41. a long liquid inlet pipe; 42. a short liquid inlet pipe; 43. an infusion tube; 44. a liquid mixing tee joint; 45. connecting a tee joint; 5. a controller; 6. a bidirectional pressure supply device; 61. a two-way air inlet fan; 62. a pressure-resistant cavity; 63. a replaceable airbag; 64. a shielding door; 65. a connecting pipe; 7. a stem cell capacity detector; 71. a light emitter; 72. a light receiver; 8. a clamp valve; 81. a brine valve; 82. a blood transfusion valve; 83. a liquid mixing valve; 84. a check valve; 85. a pressure supply valve; 86. operating the semi-ring; 87. a stationary half ring; 88. a clamping hoop; 89. a closure assembly; 891. an electric telescopic rod; 892. a rubber push plate.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
As described in the background art, the present application provides a hematopoietic stem cell reinfusion device to solve the above technical problems.
Referring to fig. 1 to 10, a hematopoietic stem cell reinfusion apparatus includes a telescopic bracket 1, and further includes: a saline bag 2, a blood transfusion bag 3, a blood transfusion pipeline 4 and a blood transfusion control system; the saline bag 2 and the blood transfusion bag 3 are respectively mounted on the telescopic bracket 1, and the mounting height of the saline bag 2 is higher than that of the blood transfusion bag 3; the blood transfusion pipeline 4 comprises a long liquid inlet pipe 41, a short liquid inlet pipe 42 and a liquid delivery pipe 43, and the long liquid inlet pipe 41, the short liquid inlet pipe 42 and the liquid delivery pipe 43 are connected through a liquid mixing tee joint 44; the blood transfusion line 4 is used for connecting the saline bag 2 and the blood transfusion bag 3 through a long liquid inlet pipe 41 and a short liquid inlet pipe 42 respectively, and the blood transfusion line 4 transfuses blood to a human body through a transfusion pipe 43; the blood transfusion control system comprises a controller 5, a bidirectional pressure supply device 6, a stem cell capacity detector 7 and a plurality of clamping valves 8; the infusion control system is used for controlling the flow direction of the liquid in the blood transfusion pipeline 4, and the infusion control system is also used for providing the flow power of the liquid in the blood transfusion pipeline 4.
When in practical application, the telescopic bracket comprises a supporting rod and a telescopic rod, a first hanging frame is arranged at the top end of one side of the telescopic rod, a second hanging frame is arranged at the middle part of the other side of the telescopic rod, the height of the first hanging frame is 20-50cm higher than that of the second hanging frame, the saline bag 2 is mounted on the first hanging frame, and the blood transfusion bag 3 is mounted on the second hanging frame, so that the mounting height of the saline bag 2 is higher than that of the blood transfusion bag.
Further, referring to fig. 10, the stem cell volume detector 7 is mounted on the outside of the blood transfusion bag 3, and the stem cell volume detector 7 includes a light emitter 71 and a light receiver 72, wherein the light emitter 71 emits light and the light is received by the light receiver 72 after passing through the blood transfusion bag 3; the stem cell volume detector 7 transmits the illumination intensities of the respective heights received by the light receiver 72 to the controller 5, and the controller 5 judges the stem cell volume inside the blood transfusion bag 3 based on the illumination intensities of the respective heights.
The detection principle of the stem cell volume detector 7 is as follows, since the stem cells are red liquid, the light emitter 71 emits light, the light is blocked by the stem cells and attenuated, and since the transfusion bag 3 is transparent, in the stem cell feedback process, the stem cells remained in the transfusion bag 3 exist at the bottom of the transfusion bag 3 due to gravity, therefore, when the light passes through the transfusion bag 3, the height of the stem cells in the transfusion bag 3 can be determined by the intensity of illumination intensity received by each height of the light receiver 72, and therefore, the height of the transfusion bag 3 can be detected by the stem cell volume detector 7, thereby determining the real-time volume of the stem cells in the transfusion bag 3.
Referring to fig. 1 to 4, a plurality of holding valves 8 are respectively installed at different positions of the blood transfusion line 4, the plurality of holding valves 8 are divided into a brine valve 81, a blood transfusion valve 82, a liquid mixing valve 83, a check valve 84 and a pressure supply valve 85 according to the different installation positions, and the plurality of holding valves 8 are used for controlling to open and close the corresponding blood transfusion line 4; the saline valve 81 and the blood transfusion valve 82 are respectively arranged on the long liquid inlet pipe 41 and the short liquid inlet pipe 42, the liquid mixing valve 83 and the check valve 84 are respectively arranged on two sides of a Murphy dropper of the infusion pipe 43 from top to bottom, and the pressure supply valve 85 is arranged on the outer side of the bidirectional pressure supply device 6; the plurality of holding valves 8 are respectively connected with the controller 5 in a signal way, and the controller 5 controls the opening and closing of each holding valve 8.
Referring to fig. 5 to 6, the bidirectional pressure supply device 6 includes a bidirectional air inlet fan 61, a pressure-resistant chamber 62, and a replaceable air bag 63; the pressure-resistant cavity 62 of the bidirectional pressure supply device is opened at the side surface, a shielding door 64 is arranged at the outer side of the side surface opening, and the shielding door 64 is used for keeping the pressure-resistant cavity 62 closed; the shield door 64 is provided with a fixing opening at the center for fixing the replaceable airbag 63; the bidirectional air inlet fan 61 is connected with the pressure-proof cavity 62, and the bidirectional air inlet fan 61 is used for controlling the pressure inside the pressure-proof cavity 62.
The replaceable airbag 63 is arranged inside the pressure-resistant cavity 62, and a connecting port of the replaceable airbag 63 penetrates out of the pressure-resistant cavity 62 through a fixed opening; a connecting tee 45 is arranged between the liquid mixing valve 83 and the check valve 84 of the infusion tube 43; the replaceable air bag 63 is communicated with the blood transfusion pipeline 4 through a connecting pipe 65 and a connecting tee joint 45; the pressure supply valve 85 is provided at an end of the connection pipe 65 near the replaceable airbag 63.
The controller 5 divides the stem cell reinfusion process into a blood transfusion stage, a pressurization stage and a flushing stage according to the stem cell capacity in the blood transfusion bag 3 detected by the stem cell capacity detector 7; in each of the blood transfusion stage, the pressurization stage and the flushing stage, the opening and closing conditions of the plurality of holding valves 8 in the different stages are controlled by the controller 5, respectively, and the pressure-resistant chamber 62 is supplied with different pressures in the different stages by the controller 5 controlling the bidirectional air intake fan 61.
Further, referring to fig. 7-9, the clamp valve 8 includes an operating half ring 86 and a fixing half ring 87, wherein one ends of the operating half ring 86 and the fixing half ring 87 are rotatably connected, and the other ends of the operating half ring 86 and the fixing half ring 87 are magnetically connected; the operating half ring 86 and the fixing half ring 87 form a ring shape, and a clamping hoop 88 is arranged in the ring shape formed by the operating half ring 86 and the fixing half ring 87, and the clamping hoop 88 is used for installing the clamping valve 8 at the corresponding position of the blood transfusion pipeline 4.
A sealing component 89 is arranged in the center of the outer side of the operation semi-ring 86, and the sealing component 89 is used for sealing the corresponding position of the blood transfusion pipeline 4 by controlling the compression of the blood transfusion pipeline 4 at the corresponding position; the sealing assembly 89 comprises an electric telescopic rod 891 and a rubber push plate 892, wherein a fixed end of the electric telescopic rod 891 is fixed with the inner wall of the operation semi-ring 86, a telescopic end of the electric telescopic rod 891 penetrates into an annular interior formed by the operation semi-ring 86 and the fixed semi-ring 87, and the telescopic end of the electric telescopic rod 891 is fixed with the rubber push plate 892; the electric telescopic rod 891 is controlled by the controller 5 to move, and the electric telescopic rod 891 is used for pushing the rubber push plate 892 to press and close the corresponding position of the blood transfusion pipeline 4.
Working principle: when in use, the telescopic bracket 1 is firstly adjusted to a proper height, then the saline bag 2 is mounted to a higher position of the telescopic bracket 1, then the stem cell capacity detector 7 is mounted on the outer side of the blood transfusion bag 3, then the blood transfusion bag 3 and the stem cell capacity detector 7 are mounted to a lower position of the telescopic bracket 1 together, then the blood transfusion pipeline 4 and the connecting pipe 65 are respectively connected to corresponding positions, and finally each clamping valve 8 is mounted to the corresponding position to finish preparation work.
The working principle of the clamping valve 8 is as follows, since one ends of the operating semi-ring 86 and the fixing semi-ring 87 are rotationally connected, the other ends of the operating semi-ring 86 and the fixing semi-ring 87 are magnetically connected, and the magnetic connecting ends of the operating semi-ring 86 and the fixing semi-ring 87 can be separated or closed, when the magnetic connecting ends of the operating semi-ring 86 and the fixing semi-ring 87 are separated, the corresponding positions of the blood transfusion pipeline 4 are placed in the operating semi-ring 86 and the fixing semi-ring 87, then the operating semi-ring 86 and the fixing semi-ring 87 are closed, the clamping hoop 88 clamps the blood transfusion pipeline 4, and the clamping valves 8 are respectively fixed at the corresponding positions.
The sealing assemblies 89 of the clamping valves 8 are respectively controlled by the controller 5, the electric telescopic rods 891 of the sealing assemblies 89 are controlled by the controller 5 to stretch and retract, when the electric telescopic rods 891 extend to the longest state, the rubber push plates 892 contact and press the corresponding positions of the blood transfusion pipelines 4, the corresponding positions of the blood transfusion pipelines 4 are sealed by the pressing of the rubber push plates 892, and accordingly the on-off of the corresponding positions of the blood transfusion pipelines 4 is controlled by the sealing assemblies 89.
The stem cell volume detector 7 transmits light through the light transmitter 71 and then is received by the light receiver 72 after passing through the blood transfusion bag 3, and due to gravity, the residual stem cells inside the blood transfusion bag 3 exist at the bottom of the blood transfusion bag 3, so that when the light passes through the blood transfusion bag 3, the light is blocked by the stem cells when the stem cells exist at the corresponding height of the blood transfusion bag 3, the illumination intensity transmitted to the light receiver 72 is lower, and when the stem cells do not exist at the corresponding height of the blood transfusion bag 3, the light passes through the transparent blood transfusion bag 3, the illumination intensity transmitted to the light receiver 72 is higher, and therefore, the real-time volume of the stem cells inside the blood transfusion bag 3 is judged through the intensity of the illumination intensity received at each height of the light receiver 72.
The real-time capacity of the stem cells in the blood transfusion bag 3 detected by the stem cell capacity detector 7 is transmitted to the controller 5 through signal connection, and the reinfusion process of the stem cells is divided into a blood transfusion stage, a pressurization stage and a flushing stage in the controller 5, and the separation of the three stages is determined by the capacity of the stem cells in the blood transfusion bag 3:
the transfusion phase is when the real-time capacity of stem cells inside the transfusion bag is greater than two fifths of the total capacity of the transfusion bag 3;
the pressurization phase when the real-time capacity of stem cells inside the transfusion bag is less than two-fifths of the total capacity of the transfusion bag 3 and greater than one-tenth of the total capacity of the transfusion bag 3;
the flushing phase is when the real-time volume of stem cells inside the transfusion bag is less than one tenth of the total volume of the transfusion bag 3.
When the real-time capacity of the stem cells is in the blood transfusion stage, the saline valve 81 and the pressure supply valve 85 are closed, and the blood transfusion valve 82, the liquid mixing valve 83 and the check valve 84 are opened under the control of the controller 5, so that the short liquid inlet pipe 42 and the liquid delivery pipe 43 are communicated; stem cells in the blood transfusion bag 3 are introduced into the human body through the short liquid inlet pipe 42 and the liquid transfer pipe 43 by gravity.
When the real-time capacity of stem cells is in the pressurization phase, inside the pressurization phase, first the controller 5 controls, the saline valve 81 and the check valve 84 to be closed, the pressure supply valve 85, the blood transfusion valve 82 and the liquid mixing valve 83 to be opened, so that the short liquid inlet pipe 42, the liquid transfer pipe 43 and the connection pipe 65 are communicated, and a negative pressure environment is provided to the pressure-resistant chamber 62 through the bidirectional air inlet fan 61, so that the replaceable air bag 63 sucks stem cells from the blood transfusion bag 3 into the replaceable air bag 63 under the negative pressure environment of the pressure-resistant chamber 62;
inside the pressurization phase, when the real-time capacity of stem cells inside the blood transfusion bag reaches one tenth of the total capacity of the blood transfusion bag 3, under the control of the controller 5, the blood transfusion valve 82 is turned from open to closed, the check valve 84 is turned from closed to open, the negative pressure environment in the pressure-resistant cavity 62 is converted into the positive pressure environment by the bidirectional air inlet fan 61, so that the replaceable air bag 63 inputs stem cells from the replaceable air bag 63 into the inside of the human body through the infusion tube 43 under the positive pressure environment of the pressure-resistant cavity 62.
When the real-time capacity of stem cells is in the flushing stage, firstly, the blood transfusion valve 82 and the check valve 84 are closed by the controller 5, the saline valve 81, the pressure supply valve 85 and the liquid mixing valve 83 are opened so that the long liquid inlet pipe 41, the liquid delivery pipe 43 and the connecting pipe 65 are communicated, and the pressure-resistant cavity 62 is provided with a negative pressure environment by the bidirectional air inlet fan 61, so that the replaceable airbag 63 sucks physiological saline from the saline bag 2 into the replaceable airbag 63 under the negative pressure environment of the pressure-resistant cavity 62;
after a certain amount of physiological saline is sucked into the replaceable air bag 63, the saline valve 81 is changed from open to closed by the controller 5, the blood transfusion valve 82 is changed from closed to open, so that the short liquid inlet pipe 42, the liquid delivery pipe 43 and the connecting pipe 65 are communicated, the negative pressure environment in the pressure-resistant cavity 62 is changed into positive pressure environment by the bidirectional air inlet fan 61, and the physiological saline is input into the blood transfusion bag 3 from the replaceable air bag 63 through the liquid delivery pipe 43 and the short liquid inlet pipe 42 under the action of the positive pressure environment of the pressure-resistant cavity 62 by the replaceable air bag 63;
after the normal saline is completely injected into the blood transfusion bag 3, the positive pressure environment in the pressure-resistant cavity 62 is converted into the negative pressure environment through the bidirectional air inlet fan 61, the normal saline in the blood transfusion bag 3 and a small amount of stem cells remained in the blood transfusion bag 3 are pumped into the replaceable air bag 63, and the pressure-resistant cavity 62 is controlled by the controller 5 to repeatedly perform positive and negative pressure circulation, so that the normal saline and a small amount of stem cells repeatedly flow through the blood transfusion bag 3-short liquid inlet pipe 42-the liquid delivery pipe 43-the connecting pipe 65-the replaceable air bag 63, and the blood transfusion bag 3, the short liquid inlet pipe 42, the liquid delivery pipe 43, the connecting pipe 65 and the replaceable air bag 63 are flushed.
After cyclic flushing for a period of time, normal saline and a small amount of stem cells are pumped into the replaceable air bag 63, then the saline valve 81, the blood transfusion valve 82 and the liquid mixing valve 83 are controlled by the controller 5 to be closed, the check valve 84 and the pressure supply valve 85 are opened, then the negative pressure environment in the pressure-resistant cavity 62 is converted into a positive pressure environment through the two-way air inlet fan 61, and the normal saline and a small amount of stem cells are input into a human body through the infusion tube 43, so that the reinfusion process of the stem cells is completed.
In the process of reinfusion of stem cells, when the real-time capacity of the stem cells inside the transfusion bag is smaller than two fifths of the total capacity of the transfusion bag 3 and is larger than one tenth of the total capacity of the transfusion bag 3, the stem cells in the transfusion bag 3 are pumped into the interior of the replaceable air bag 63 through the pressurizing and conveying process of the pressurizing stage, and then the stem cells are input into the human body from the interior of the replaceable air bag 63, in the pressurizing stage, the stem cells are pumped into the replaceable air bag 63 from the transfusion bag 3 through the bidirectional air inlet fan 61 and the pressure-resistant cavity 62, and the conveying power of the stem cells is input into the human body from the interior of the replaceable air bag 63, so that the viscous effect of the transfusion bag 3 on the stem cells is fully dealt with, the conveying speed of the stem cells is fully maintained, and the activity of the stem cells is fully ensured in the rapid conveying process.
In the stem cell reinfusion process, when the real-time capacity of stem cells in the blood transfusion bag is less than one tenth of the total capacity of the blood transfusion bag 3, a flushing stage is carried out, the pressure-resistant cavity 62 is controlled by the controller 5 to repeatedly carry out positive and negative pressure circulation, so that physiological saline and a small amount of stem cells repeatedly flow through the blood transfusion bag 3-short liquid inlet pipe 42-liquid delivery pipe 43-connecting pipe 65-replaceable air bag 63, and flush the blood transfusion bag 3, the short liquid inlet pipe 42, the liquid delivery pipe 43, the connecting pipe 65 and the replaceable air bag 63, thereby ensuring that the stem cells can be completely input into a human body, reducing the loss of the stem cells and improving the blood transfusion effect.
The controller 5 is used for controlling the reinfusion process of the stem cells in stages according to the real-time capacity of the stem cells in the blood transfusion bag 3, so that the reinfusion process of the stem cells can be fully controlled, the stem cells can be quickly and completely input into a human body in stages under the control of the controller 5, the problem of misoperation which is easy to occur manually is solved through the intervention of automatic control, the accuracy of the blood transfusion process is ensured, and bacteria in the process of continuously performing plug flushing by the intervention of automatic control are exposed, so that the risk of bacterial infection in the blood transfusion process is reduced.
In practical use, the saline bag 2, the blood transfusion bag 3, the blood transfusion line 4, the replaceable air bag 63 and the connection tube 65 are disposable replaceable items to prevent the risk of blood contamination by special persons.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. A hematopoietic stem cell reinfusion device comprising a telescopic bracket (1), characterized in that it further comprises: a saline bag (2), a blood transfusion bag (3), a blood transfusion pipeline (4) and a blood transfusion control system;
the saline bag (2) and the blood transfusion bag (3) are respectively mounted on the telescopic bracket (1), and the mounting height of the saline bag (2) is higher than that of the blood transfusion bag (3);
the blood transfusion pipeline (4) comprises a long liquid inlet pipe (41), a short liquid inlet pipe (42) and a liquid conveying pipe (43), wherein the long liquid inlet pipe (41), the short liquid inlet pipe (42) and the liquid conveying pipe (43) are connected through a liquid mixing tee joint (44);
the blood transfusion line (4) is used for connecting the saline bag (2) and the blood transfusion bag (3) through the long liquid inlet pipe (41) and the short liquid inlet pipe (42) respectively, and the blood transfusion line (4) is used for blood transfusion to a human body through the liquid transfusion pipe (43);
the blood transfusion control system comprises a controller (5), a bidirectional pressure supply device (6), a stem cell capacity detector (7) and a plurality of clamping valves (8);
the blood transfusion control system is used for controlling the flow direction of liquid in the blood transfusion pipeline (4), and is also used for providing the flow power of the liquid in the blood transfusion pipeline (4);
the clamping valves (8) are respectively arranged at different positions of the blood transfusion pipeline (4), the clamping valves (8) are divided into a brine valve (81), a blood transfusion valve (82), a liquid mixing valve (83), a check valve (84) and a pressure supply valve (85) according to the different installation positions, and the clamping valves (8) are used for controlling the corresponding blood transfusion pipeline (4) to be opened and closed;
the saline valve (81) and the blood transfusion valve (82) are respectively arranged on the long liquid inlet pipe (41) and the short liquid inlet pipe (42), the liquid mixing valve (83) and the check valve (84) are respectively arranged on two sides of a Murphy dropper of the infusion pipe (43) from top to bottom, and the pressure supply valve (85) is arranged on the outer side of the bidirectional pressure supply device (6);
the clamping valves (8) are respectively connected with the controller (5) in a signal manner, and the controller (5) controls the opening and closing of each clamping valve (8);
the bidirectional pressure supply device (6) comprises a bidirectional air inlet fan (61), a pressure-resistant cavity (62) and a replaceable air bag (63);
a side surface opening of a pressure-resistant cavity (62) of the bidirectional pressure supply device is provided with a shielding door (64) at the outer side of the side surface opening, and the shielding door (64) is used for keeping the pressure-resistant cavity (62) closed;
the center of the shielding door (64) is provided with a fixing opening which is used for fixing the replaceable air bag (63);
the bidirectional air inlet fan (61) is connected with the pressure-resistant cavity (62), and the bidirectional air inlet fan (61) is used for controlling the pressure intensity inside the pressure-resistant cavity (62).
2. The hematopoietic stem cell reinfusion device of claim 1, wherein: the stem cell capacity detector (7) is arranged on the outer side of the blood transfusion bag (3) in a mounting mode, the stem cell capacity detector (7) comprises a light emitter (71) and a light receiver (72), and the light emitter (71) emits light to pass through the blood transfusion bag (3) and then is received by the light receiver (72);
the stem cell capacity detector (7) transmits the illumination intensity of each height received by the light receiver (72) to the controller (5), and the controller (5) judges the stem cell capacity inside the blood transfusion bag (3) according to the illumination intensity of each height.
3. The hematopoietic stem cell reinfusion device of claim 2, wherein: the replaceable airbag (63) is arranged inside the pressure-resistant cavity (62), and a connecting port of the replaceable airbag (63) penetrates out of the pressure-resistant cavity (62) through the fixed opening;
a connecting tee joint (45) is arranged between the liquid mixing valve (83) and the check valve (84) of the infusion tube (43);
the replaceable air bag (63) is communicated with the blood transfusion pipeline (4) through a connecting pipe (65) and the connecting tee joint (45);
the pressure supply valve (85) is arranged at one end of the connecting pipe (65) close to the replaceable air bag (63).
4. A hematopoietic stem cell reinfusion device according to claim 3, wherein: the controller (5) divides the stem cell reinfusion process into a blood transfusion stage, a pressurization stage and a flushing stage according to the stem cell capacity in the blood transfusion bag (3) detected by the stem cell capacity detector (7);
in each of the blood transfusion stage, the pressurization stage and the flushing stage, the opening and closing conditions of a plurality of clamping valves (8) in different stages are respectively controlled by a controller (5), and the bidirectional air inlet fan (61) is controlled by the controller (5) to provide different pressures for the pressure-proof cavity (62) in different stages.
5. The hematopoietic stem cell reinfusion device of claim 1, wherein: the clamping valve (8) comprises an operation semi-ring (86) and a fixed semi-ring (87), wherein one end of the operation semi-ring (86) is rotationally connected with one end of the fixed semi-ring (87), and the other end of the operation semi-ring (86) is magnetically connected with the other end of the fixed semi-ring (87);
the operation semi-ring (86) and the fixing semi-ring (87) form a ring shape, a clamping hoop (88) is arranged inside the ring shape formed by the operation semi-ring (86) and the fixing semi-ring (87), and the clamping hoop (88) is used for installing the clamping valve (8) at the corresponding position of the blood transfusion pipeline (4).
6. The hematopoietic stem cell reinfusion device of claim 5, wherein: a sealing component (89) is arranged in the center of the outer side of the operation semi-ring (86), and the sealing component (89) is used for sealing the corresponding position of the blood transfusion pipeline (4) by controlling the compression of the blood transfusion pipeline (4) at the corresponding position;
the sealing assembly (89) comprises an electric telescopic rod (891) and a rubber push plate (892), wherein the fixed end of the electric telescopic rod (891) is fixed with the inner wall of the operation semi-ring (86), the telescopic end of the electric telescopic rod (891) penetrates into the annular interior formed by the operation semi-ring (86) and the fixing semi-ring (87), and the telescopic end of the electric telescopic rod (891) is fixed with the rubber push plate (892);
the electric telescopic rod (891) is controlled to move by the controller (5), and the electric telescopic rod (891) is used for pushing the rubber push plate (892) to press and seal the corresponding position of the blood transfusion pipeline (4).
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| CN202111025642.3A CN113769200B (en) | 2021-09-02 | 2021-09-02 | Hematopoietic stem cell reinfusion device |
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| CN202111025642.3A CN113769200B (en) | 2021-09-02 | 2021-09-02 | Hematopoietic stem cell reinfusion device |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008008322A2 (en) * | 2006-07-10 | 2008-01-17 | Wilson Roland B | Y-type blood transfusion set |
| CN109731179A (en) * | 2019-03-06 | 2019-05-10 | 河北华蓝医疗器械有限公司 | It is a kind of for medical first aid blood transfusion, infusion bag stabilization pressurized equipment |
| CN209529820U (en) * | 2018-12-10 | 2019-10-25 | 扬州市皓联电子科技有限公司 | A kind of intelligent transfusion blood transfusion pressure is packed to be set |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050177089A1 (en) * | 2004-02-10 | 2005-08-11 | George Lee | Automatic pressurized liquid transfusion apparatus |
| CN108744118A (en) * | 2018-05-24 | 2018-11-06 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | A kind of medical infusion device |
| CN112043913A (en) * | 2019-06-05 | 2020-12-08 | 陈舒媛 | Automatic monitoring system for hospital infusion tube |
| CN111729150A (en) * | 2020-06-20 | 2020-10-02 | 昆明医科大学第一附属医院 | Stem cell feedback device and using method |
-
2021
- 2021-09-02 CN CN202111025642.3A patent/CN113769200B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008008322A2 (en) * | 2006-07-10 | 2008-01-17 | Wilson Roland B | Y-type blood transfusion set |
| CN209529820U (en) * | 2018-12-10 | 2019-10-25 | 扬州市皓联电子科技有限公司 | A kind of intelligent transfusion blood transfusion pressure is packed to be set |
| CN109731179A (en) * | 2019-03-06 | 2019-05-10 | 河北华蓝医疗器械有限公司 | It is a kind of for medical first aid blood transfusion, infusion bag stabilization pressurized equipment |
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