CN113729853B

CN113729853B - Bolt breaking support, bolt breaking device and bolt taking system

Info

Publication number: CN113729853B
Application number: CN202110820054.2A
Authority: CN
Inventors: 陈学明; 李建民; 周祥; 王永胜
Original assignee: Hangzhou Wei Qiang Medical Technology Co ltd
Current assignee: Hangzhou Wei Qiang Medical Technology Co ltd
Priority date: 2021-04-09
Filing date: 2021-07-20
Publication date: 2023-11-07
Anticipated expiration: 2041-07-20
Also published as: WO2022214020A1; CN113729854B; CN113729852A; CN115192139A; CN113729853A; CN113729852B; CN113729854A

Abstract

The invention relates to a thrombus breaking bracket, a thrombus breaking device and a thrombus taking system. A thrombus breaking stent for cutting a thrombus in a blood vessel, the thrombus breaking stent comprising: a fixing member; one end of the first bracket is connected with the fixing piece, and the fixing piece rotates to drive the first bracket to rotate to form a first rotary cutting curved surface for cutting the thrombus; one end of the second bracket is connected with the fixing piece, and the fixing piece rotates to drive the second bracket to rotate to form a second rotary cutting curved surface for cutting the thrombus; wherein, the first rotary cutting curved surface and the second rotary cutting curved surface have a space at least partially. The bolt breaking device comprises a conveying pipe and a bolt breaking bracket. The bolt taking system comprises a bolt breaking device and a bolt taking device.

Description

Bolt breaking support, bolt breaking device and bolt taking system

Technical Field

The invention relates to the technical field of medical equipment, in particular to a thrombus breaking bracket, a thrombus breaking device and a thrombus taking system.

Background

Venous Thromboembolism (VTE) includes lower limb Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE).

Deep Vein Thrombosis (DVT) of the lower limb is a high vascular surgical disease, and is mostly caused by blood reflux obstruction due to abnormal blood coagulation in the vein of the lower limb. Pulmonary Embolism (PE) has become the third leading cause of death from cardiovascular disease. Risk factors for pulmonary embolism include both environmental factors and personal factors including age, past history of VTE, history of tumor, heart and lung failure, congenital or acquired coagulation dysfunction, hormonal therapy, and the like. Acute PE can lead to systemic hypotension and even total heart failure, leading to patient death.

Therefore, the thrombus can be quickly and effectively cleared as soon as possible, vein blockage can be relieved, PE can be effectively prevented, valve functions can be protected, and the thrombus recurrence rate can be reduced.

The existing bolt breaking device is poor in bolt breaking effect.

Disclosure of Invention

The application provides a thrombus breaking bracket, a thrombus breaking device and a thrombus taking system.

A thrombus reduction stent for cutting a thrombus within a vessel, the thrombus reduction stent comprising:

a fixing member;

one end of the first bracket is connected with the fixing piece, and the fixing piece rotates to drive the first bracket to rotate to form a first rotary cutting curved surface for cutting the thrombus;

one end of the second bracket is connected with the fixing piece, and the fixing piece rotates to drive the second bracket to rotate to form a second rotary cutting curved surface for cutting the thrombus;

wherein, the first rotary cutting curved surface and the second rotary cutting curved surface have a space at least partially.

In one embodiment, the second rotary cutting curve is encased within the first rotary cutting curve.

In one embodiment, the fixing member is capable of rotating around a rotation axis, the first support is rotated to form the first rotary cutting curved surface, the second support is rotated to form the second rotary cutting curved surface, and the maximum radial distance between the first support and the rotation axis is greater than the maximum radial distance between the second support and the rotation axis.

In one embodiment, the second rotary cutting curve intersects the first rotary cutting curve.

In one embodiment, the connection of the first bracket and the fixing member is located on the distal side of the connection of the second bracket and the fixing member;

the distal end of the first stent is fixedly connected with the distal end of the second stent, and the distal end side end of the first stent is located on the distal side of the distal end side end of the second stent.

In one embodiment, the bolt breaking support comprises a first circular ring and a second circular ring, the other end of the first support is connected with the first circular ring, and the other end of the second support is connected with the second circular ring.

In one embodiment, the first ring and the second ring are separately provided.

In one embodiment, the second ring is located between the first ring and the mount.

In one embodiment, the bolt breaking support comprises a third circular ring, and the other ends of the first support and the second support are connected with the third circular ring.

In one embodiment, the first support is an elastic support, and the other end of the first support can elastically approach or separate from the fixing piece; the second support is an elastic support, and the other end of the second support can elastically approach or depart from the fixing piece.

In one embodiment, the first bracket comprises a plurality of first cutting rods, one ends of the first cutting rods are connected with the fixing piece, and the other ends of the first cutting rods are fixedly connected;

the second support comprises a plurality of second cutting rods, one ends of the second cutting rods are connected with the fixing piece, and the other ends of the second cutting rods are fixedly connected.

In one embodiment, the first cutting bars and the second cutting bars are staggered in the circumferential direction.

In one embodiment, the fixing member has a tubular structure with an inner cavity, and the peripheral wall of the fixing member is provided with an opening communicated with the inner cavity, and the opening is used for enabling glue to enter the inner cavity to fixedly connect the fixing member and a conveying pipe penetrating into the inner cavity.

In one embodiment, the fixing member includes a first fixing tube and a second fixing tube, the second fixing tube is connected to a distal end of the first fixing tube, the first bracket is connected to the first fixing tube, and the second bracket is connected to the second fixing tube.

In one embodiment, a clamping groove is concavely formed at the distal end of the first fixing tube, and a clamping protrusion matched with the clamping groove is convexly formed at the proximal end of the second fixing tube; the clamping protrusion is connected in the clamping groove in a jogged mode, so that the second fixing tube is coaxially connected to the far end of the first fixing tube.

The bolt breaking device comprises a conveying pipe and a bolt breaking support, wherein the conveying pipe is fixedly connected with the fixing piece.

In one embodiment, the ends of the first bracket and the second bracket far away from the fixing piece are both connected with the conveying pipe in a sliding way.

In one embodiment, the thrombus breaking device further comprises a driving handle, wherein the driving handle is connected to the proximal end of the conveying pipe and can drive the conveying pipe and the thrombus breaking support to rotate along the circumferential direction.

In one embodiment, the bolt breaking device further comprises a loading pipe, and the loading pipe is movably sleeved on the conveying pipe; the loading tube can move to the far end of the conveying tube and is sleeved on the bolt breaking support, so that the first support and the second support are both accommodated in the loading tube.

A tie-down system, comprising: the bolt breaking device is used for breaking the bolt,

the thrombus taking device comprises a thrombus taking bracket, a traction catheter connected with the thrombus taking bracket and an outer sheath, wherein the traction catheter and the thrombus taking bracket are connected in the outer sheath in a sliding manner, and the traction catheter drives the thrombus taking bracket to extend or retract out of the outer sheath; the thrombus taking support extends out of the outer sheath tube and is in an expansion state; the thrombus taking support retracts into the outer sheath tube, and the thrombus taking support is in a compressed state;

The broken bolt support and the conveying pipe are both connected in the traction guide pipe in a sliding manner, and the conveying pipe drives the broken bolt support to extend out of or retract into the traction guide pipe; the broken bolt bracket extends out of the traction catheter and enters the bolt taking bracket, and the broken bolt bracket is changed from a compressed state to an expanded state; the conveying pipe drives the broken bolt support to rotate in the bolt taking support, and the broken bolt support and the bolt taking support are spaced when rotating.

As can be seen from the technical scheme, the embodiment of the invention has at least the following advantages and positive effects:

the fixing piece is utilized to rotate to drive the first support and the second support to rotate, the first support rotates to form a first rotary cutting curved surface for cutting thrombus, and the second support rotates to form a second rotary cutting curved surface for cutting thrombus. When the thrombus is positioned at the first rotary cutting curved surface and the second rotary curved surface, the thrombus can be impacted by the first bracket and the second bracket to be cut into small pieces. When the first support or the second support impacts and cuts thrombus, the thrombus can be driven to move to a certain extent under the inertia of the thrombus, as the first rotary cutting curved surface and the second rotary cutting curved surface are provided with intervals, a part of thrombus blocks can pass through the first rotary cutting curved surface again during movement, and another part of thrombus blocks can pass through the second rotary cutting curved surface again, so that on one hand, when the same thrombus block moves in different directions, the probability of being cut again by the first support or the second support can be improved, on the other hand, the thrombus at different positions can be cut by the first support and the second support, and the area for cutting the thrombus is enlarged. So that the thrombus blocks can be crushed smaller and more fully, and the thrombus crushing effect is improved.

Drawings

Fig. 1 is a schematic view showing the overall structure of a thrombus removal system according to a first embodiment of the present invention.

Fig. 2 is a partial perspective view of the thrombolytic system of fig. 1.

Fig. 3 is a schematic view of the structure of the thrombolytic stent of fig. 1.

Fig. 4 is a top view of fig. 3.

Fig. 5 is an enlarged schematic view of the area a in fig. 4.

Fig. 6 is a schematic view of the structure of the separation bracket of fig. 3.

Fig. 7 is a side view of fig. 6.

Fig. 8 is a schematic view of the structure of the support bracket of fig. 3.

Fig. 9 is a side view of fig. 8.

Fig. 10 is a schematic view of the structure of the filter membrane of fig. 3.

Fig. 11 is a side view of fig. 10.

Fig. 12 is a schematic view of the latch breaking device of fig. 1.

Fig. 13 is a schematic view of the structure of the first embodiment of the bolt crushing bracket in fig. 12.

Fig. 14 is a side view of fig. 13.

Fig. 15 is a top view of fig. 13.

Fig. 16 is a schematic view of the construction of a second embodiment of the thrombolytic stent of fig. 12.

Fig. 17 is a side view of fig. 16.

Fig. 18 is a top view of fig. 16.

Fig. 19 is a schematic view of the structure of the first bracket in fig. 16.

Fig. 20 is a schematic view of the structure of the second bracket in fig. 16.

Fig. 21 is a schematic view of the structure of the third embodiment of the bolt carrier of fig. 12.

Fig. 22 is a side view of fig. 21.

Fig. 23 is a schematic structural view of a fourth embodiment of the bolt carrier of fig. 12.

Fig. 24 is a schematic view of the structure of the outer sheath of fig. 1.

Fig. 25 is a schematic view of the construction of the sheath tube joint in fig. 24.

Fig. 26 is a schematic view of the pull catheter, connector catheter, and branch catheter of fig. 1.

Fig. 27 is a cross-sectional view of the joint guide tube of fig. 26.

Fig. 28 is a schematic view of a lesion of a human inferior vena cava.

Fig. 29 is a schematic view of the embolization system of fig. 1 penetrating into a lesion.

Fig. 30 is a schematic view of the initial release of the thrombolytic stent.

Fig. 31 is a schematic view of the release and adjustment of the thrombolytic stent.

Fig. 32 is a schematic view of the thrombolytic stent after release.

Fig. 33 is a schematic view of the removal of the thrombus from the stent and collection of the thrombus within the vessel.

Fig. 34 is a schematic diagram showing the operation of the thrombus breaking device in breaking thrombus in the thrombus taking out stent.

Fig. 35 is a schematic view of the withdrawal of the thrombolytic device after completion of the thrombolysis.

Fig. 36 is a schematic view of aspiration thrombus.

Fig. 37 is a schematic view of the thrombolytic stent again detached and thrombus collected.

Fig. 38 is a schematic view of the thrombolytic device re-entering the connector conduit and the traction conduit.

Fig. 39 is a schematic view of aspiration thrombus of the second embodiment of the present invention.

Fig. 40 is a schematic structural view of a thrombus removing device according to a third embodiment of the present invention.

Fig. 41 is a schematic view of the structure of fig. 40 in another state.

Fig. 42 is a schematic structural view of a fourth embodiment of the present invention.

Fig. 43 is a schematic structural view of a fifth embodiment of the present invention.

Fig. 44 is a schematic view of the structure of a sixth embodiment of the present invention.

The reference numerals are explained as follows:

01. venous blood vessels; 02. thrombotic tissue; 03. a guide wire; 04. a puncture opening; 1. an outer sheath; 11. a sheath tube joint; 12. an adjustment knob; 13. a clamp ring; 14. a silica gel ring; 15. a branch hose; 16. compressing the balloon; 111. a branch joint; 2. a traction catheter; 21. a fixed cover; 22. a chute; 3. a thrombus taking bracket; 31. separating the bracket; 32. a support bracket; 33. a filter screen film; 34. a guide head; 35. a silk thread; 310. a first diamond grid cell; 311. a support body; 312. a connecting rod; 313. a connecting ring; 320. a second diamond grid cell; 321. a support rod; 322. a fixing ring; 331. a mesh; 332. a small hole; 3131. a pull wire; 4. a delivery tube; 41. a drive handle; 42. a loading tube; 401. a drive terminal; 402. stainless steel tube; 411. a drive interface; 412. driving a wrench; 413. a rechargeable battery; 414. a drive motor; 415. a control button; 5. a bolt breaking bracket; 51. a fixed tube; 52. a first bracket; 53. a second bracket; 54. a third ring; 511. a first fixed tube; 512. a second fixed tube; 521. a first cutting bar; 522. a first ring; 531. a second cutting bar; 532. a second ring; 5111. a clamping groove; 5112. a first opening; 5121. a clamping protrusion; 5122. a second opening; 6. a connector conduit; 61. a branch conduit; 62. screwing the cover; 63. a seal ring; 64. a suction cylinder; 65. a suction catheter; 601. a branch pipe joint; 611. and a branch switch.

Detailed Description

Exemplary embodiments that embody features and advantages of the present application will be described in detail in the following description. It will be understood that the application is capable of various modifications in various embodiments, all without departing from the scope of the application, and that the description and illustrations herein are intended to be by way of illustration only and not to be construed as limiting the application.

In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present application.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more of the described features. In the description of the present application, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.

In the description of the present application, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present application will be understood in specific cases by those of ordinary skill in the art.

In the description of the present application, "radial" and "axial" are to be understood in a broad sense. "radial" is not limited to an absolute circular object, nor is "axial" limited to an absolute cylindrical object.

In the description of the present application, "proximal" refers to the end of the thrombolytic or thrombolytic stent that is proximal to the operating end (drive handle 41) and "distal" refers to the end of the thrombolytic or thrombolytic stent that is distal to the operating end (drive handle 41).

Referring to fig. 1, an embolus removing system provided by an embodiment of the present application can be used for rapidly and thoroughly removing thrombus in a blood vessel. The embolectomy system of the embodiment of the application mainly comprises an outer sheath tube 1, an embolectomy device, a embolectomy device and a suction device.

Referring to fig. 1 in combination with fig. 28 to 31, an outer sheath 1 serves as a loading container for accommodating a thrombus removing device and a thrombus crushing device, and for pulling or guiding the thrombus removing device and the thrombus crushing device into a lesion in a blood vessel.

Referring to fig. 1 and 2, the thrombectomy device includes a pull catheter 2 and an expandable thrombectomy stent 3.

The traction catheter 2 is movably arranged in the outer sheath tube 1 in a penetrating way and can move relative to the outer sheath tube 1 along the axial direction.

The thrombus taking support 3 is arranged at the far end of the traction catheter 2, and the thrombus taking support 3 can be driven by the traction catheter 2 to axially move in the outer sheath tube 1, so that the thrombus taking support 3 extends out of the outer sheath tube 1 or contracts into the outer sheath tube 1.

The thrombolytic stent 3 is a stent structure which can be contracted and expanded in the radial direction so that the thrombolytic stent 3 can be compressed into the outer sheath 1. Simultaneously, when the thrombus taking support 3 stretches out of the outer sheath tube 1, the thrombus taking support 3 can naturally expand and is attached to the inner wall of a blood vessel.

The proximal end of the thrombus-taking stand 3 has an opening, and thrombus is cut in cooperation with the peripheral wall of the thrombus-taking stand 3 so that thrombus in a blood vessel enters the inner space of the thrombus-taking stand 3 through the opening. It will be appreciated that a plurality of such openings may be provided. Simultaneously, the distal end of the thrombus taking support 3 is closed so as to be convenient for collecting and capturing thrombus, so that the thrombus is collected inside the thrombus taking support 3. It should be noted that "distal end closed" in the present application means that the distal end of the thrombus-taking scaffold 3 is sufficient to capture thrombus, for example, the distal end may be provided with an aperture for passage of blood or a guide wire, and the aperture size of the distal end is smaller than the size of the opening of the proximal end as a whole.

Referring to fig. 3 to 5, the thrombus-taking stand 3 includes a self-expanding separation stand 31, a self-expanding support stand 32, a filter membrane 33 and a guide head 34. In operation, the operator can reciprocate the thrombus-removing stent 3 along the axial direction of the blood vessel, and scrape thrombus on the inner wall of the blood vessel through the separation stent 31.

Referring to fig. 6 and 7, and in combination with fig. 3 to 5, a separation bracket 31 is formed at the proximal end of the thrombolytic bracket 3. The separation stent 31 is a stent structure that can be contracted and expanded in the radial direction.

The proximal end of the separation stent 31 is connected to the pull catheter 2. The "connection" may be a fixed connection along an axial direction or a sliding connection along an axial direction, and the case of the fixed connection is described first in this embodiment, and the case of the sliding connection is described in the following embodiments. The proximal end of the separation stent 31 is formed with an opening, i.e., a proximal opening as the thrombolytic stent 3, for harvesting thrombus within the vessel. The distal end of the separation bracket 31 is connected to the proximal end of the support bracket 32 so that the separation bracket 31 is engaged with the support bracket 32 and the inside of the separation bracket 31 is communicated with the inside of the support bracket 32. It should be noted that "the separation bracket 31 is engaged with the support bracket 32" means that the separation bracket 31 and the support bracket 32 may be separately processed and then connected together, or the separation bracket 31 and the support bracket 32 may be directly integrally formed into a whole.

Referring to fig. 6 and 7, the separation bracket 31 of the present embodiment includes a supporting body 311 with a distal end connected to the supporting bracket 32, a plurality of connecting rods 312 connected to a proximal end of the supporting body 311, and a connecting ring 313 connected to a proximal end of the plurality of connecting rods 312, wherein the connecting ring 313 may be a connecting member of other structures without a through hole.

Referring to fig. 6, in combination with fig. 2, a connection ring 313 is sleeved on the traction catheter 2 to connect the thrombus taking stand 3 with the traction catheter 2.

Still referring to fig. 6 and 7, the support body 311 is a bare stent structure, and is a tubular stent structure with a circumferential closed loop in the unfolded state; or the supporting body 311 is annular in the circumferential direction and is of a net-shaped bracket structure. The supporting body 311 can provide a good radial supporting force for the separation bracket 31, so that the separation bracket 31 can better fit with the interior of the blood vessel, and further complete cutting, separation and collection of thrombus in the blood vessel and the inner wall of the blood vessel can be performed, so that the thrombus can completely enter the thrombus taking bracket 3.

In this embodiment, the support body 311 comprises a plurality of circumferentially and axially joined V-shaped bars. A plurality of V-bars connected circumferentially may form a wave ring. The wave ring has circumferentially staggered peaks and valleys, the peaks facing proximally and the valleys facing distally. Depending on the number of circumferentially connected V-bars, a different number of valleys may be formed at the distal end of the support body 311, which serve as connection points for connection with the support bracket 32.

The plurality of axially-connected V-bars may form a plurality of first diamond-shaped mesh cells 310, which first diamond-shaped mesh cells 310 may also be capable of directly cutting thrombus as the support body 311 expands, such that the thrombus enters the separation stent 31. The proximal and distal ends of the first diamond-shaped grid cell 310 may also form peaks and valleys, respectively. The number of V-shaped bars at the proximal end of the support body 311 can be adjusted stepwise to form different numbers of peaks for connection with different numbers of connecting bars 312 at the proximal end. In this embodiment, the number of troughs at the distal end of the support body 311 is greater than the number of peaks at the proximal end of the support body 311. It should be noted that the grid cells in the present application are not limited to the diamond grid cells 310, but may be grid cells of other shapes, such as oval, triangle, etc., and the sides of the grid cells may be straight sides or curved sides.

It can be appreciated that the first diamond grid cells 310 can be deformed in a stretching manner along the axial direction of the support body 311, so that the support body 311 has a strong radial supporting force and an adhesion capability of the blood vessel, and the separation bracket 31 can be compressed and expanded in the radial direction.

The filter membrane 33 is connected to at least the support bracket 32, and the filter membrane 33 is provided with a hole structure so that the filter membrane 33 is used for filtering thrombus and passing blood.

As shown in fig. 3, the elastic support strength of the separation bracket 31 is greater than that of the support bracket 32, and the flexibility of the support bracket 32 is greater than that of the separation bracket 31. The support body 311 and/or the connecting rod 312 in the separation bracket 31 are used for scraping thrombus located on the inner wall of the blood vessel. The separation bracket 31 provides better elastic supporting strength through higher elastic performance, so that the contact force between the separation bracket 31 and the inner wall of the blood vessel is larger, and thrombus on the inner wall of the blood vessel is easier to scrape off. The filter membrane 33 is connected to the support bracket 32, and the support bracket 32 provides support for the filter membrane 33, so that the filter membrane 33 maintains a relatively stable shape, and the elastic support strength of the support bracket 32 can be smaller than that of the separation bracket 31 because the support bracket 32 is not used as a core part for scraping thrombus. Since the filter membrane 33 is at least connected to the support bracket 32, the flexibility of the support bracket 32 is greater than that of the separation bracket 31, and the flexibility of the support bracket 32 is good, so that the support bracket 32 can be better suitable for deformation of the filter membrane 33, and the filter membrane 33 can be prevented from being easily broken due to the fact that the support bracket 32 has higher self elastic support strength, or the area of a hole structure on the filter membrane 33 is larger, so that the interception effect of the filter membrane 33 on thrombus is poor.

The connecting rod 312 is disposed at the proximal end of the supporting body 311, and the distal end of the connecting rod 312 is connected to the peak at the proximal end of the supporting body 311. The plurality of connecting rods 312 are circumferentially spaced apart, the proximal ends of the plurality of connecting rods 312 are collectively connected to the connecting ring 313, and a proximal opening of the separation bracket 31 is formed between adjacent connecting rods 312 and the support body 311.

As shown in fig. 7, the portion having the first diamond-shaped grid cells 310 on the left side in fig. 7 is a support body 311, and the elastic support strength of the support body 311 is greater than that of the support bracket 32. Wherein the size may be different between the plurality of first diamond-shaped grid cells 310; the connecting rod 321 is in a strip structure, and two ends of the connecting rod 321 are respectively connected with the supporting body 311 and the connecting ring 313. For example, in the embodiment shown in fig. 6, there are two connecting rods 312, and distal ends of the two connecting rods 312 are respectively connected to different first diamond grid cells 310, and proximal ends of the two connecting rods 312 are gathered and connected to a connecting ring 313, where the gathering refers to that a plurality of objects are close to each other, and may be connected to each other or not connected to each other.

The connection ring 313 is used for connecting the traction catheter 2. In this embodiment, the connection ring 313 is fixedly sleeved on the distal end of the traction catheter 2. It is understood that the connection ring 313 may be disposed on the axis of the support body 311 or may be disposed eccentrically.

It should be noted that, the whole separation bracket 31 may be manufactured by using a nickel-titanium alloy pipe through a laser cutting process and a heat setting process.

Referring to fig. 8 and 9, a support bracket 32 of the present embodiment is provided at the distal end of the separation bracket 31. The support stent 32 is a stent structure that is radially contractible and expandable. The proximal end of the support bracket 32 is axially contiguous with the support body 311 of the separation bracket 31. The distal end of the support stent 32 forms a gradually converging closed end to facilitate capturing and gathering thrombus separated from the vessel by the separation stent 31.

Referring to fig. 8 and 9, and referring to fig. 5, in the present embodiment, a plurality of second diamond-shaped grid cells 320 are formed at the proximal end of the support bracket 32, and the plurality of second diamond-shaped grid cells 320 may be formed by connecting a plurality of V-shaped rods in the circumferential direction and in the axial direction. The proximal ends of the second diamond-shaped grid elements 320 form peaks that can be connected as connection points in a one-to-one correspondence with the valleys at the distal ends of the support body 311 and are connected by winding with the wires 35, as shown in fig. 5.

The second diamond-shaped grid unit 320 can perform telescopic deformation along the axial direction of the support stent 32, so that the support stent 32 has stronger radial supporting force and the attaching capability of the blood vessel, and the support stent 32 can be compressed and expanded along the radial direction. It will be appreciated that the second diamond-shaped grid cells 320 may be provided in one or more layers in the axial direction of the support stent 32. The more the number of layers of the second diamond-shaped grid cells 320, the more radial bending capability the support stent 32. The support bracket 32 does not have to be a main structure for scraping thrombus from the thrombus wall, and thus the elastic support strength of the support bracket 32 is smaller than that of the separation bracket 31. In order to adapt the support bracket 32 to the deformation of the filter membrane 33, the filter membrane 33 is prevented from being broken or the hole structure on the filter membrane 33 is enlarged, the flexibility of the support bracket 32 is larger than that of the separation bracket 31, for example, the flexibility of the second diamond grid unit 320 is larger than that of the separation bracket 31, further, the flexibility of the second diamond grid unit 320 is larger than that of the first diamond grid unit 310, and the elastic support strength of the second diamond grid unit 320 is smaller than that of the first diamond grid unit 310.

Still referring to fig. 8 and 9, the distal end of the support bracket 32 is formed with a plurality of support rods 321 circumferentially distributed and a fixing ring 322 connected to the distal end of the support rods 321. The supporting rods 321 may extend along the axial direction of the supporting frame 32, and in the direction from the proximal end to the distal end, the radial dimension of the supporting rods 321 gradually decreases, so that the distal ends of the supporting rods 321 are gradually converged and connected to the fixing ring 322. As the distal ends of the plurality of support rods 321 approach together, the radial dimension of the structure enclosed or defined by the plurality of support rods 321 gradually decreases in the proximal-to-distal direction; alternatively, the radial dimension of the structure surrounded or defined by the plurality of support rods 321 is constant and then gradually decreases; it is also possible that the radial dimension of the structure surrounded or defined by the plurality of support rods 321 increases and then gradually decreases.

Referring to fig. 3 to 5, it should be noted that, like the separation bracket 31, the support bracket 32 may also be made of a nickel-titanium alloy pipe by a laser cutting process and a heat setting process. The wall thickness of the support bracket 32 is smaller than the wall thickness of the separation bracket 31, that is, the wall thickness of the pipe material used for the support bracket 32 is smaller than the wall thickness of the pipe material used for the separation bracket 31, so that the separation bracket 31 and the support bracket 32 are suitable for the elastic support strength and the flexibility relation in the embodiment; the wall thickness refers to the thickness of the tubular stent structure from the outer surface to the inner surface. Therefore, the support bracket 32 maintains a certain flexibility while providing a certain radial supporting force, and performs proper bending deformation by utilizing the symmetrical and unfixed characteristic of the second diamond grid unit 320, so as to better adapt to the tortuous characteristic of the blood vessel of the patient. I.e. the radial supporting force of the separation bracket 31 is larger than that of the supporting bracket 32, and the separation bracket 31 has better blood vessel adherence capability. At the same time, the flexibility of the support bracket 32 is larger than that of the separation bracket 31, and the support bracket 32 can be more suitable for the tortuous characteristic of the blood vessel.

Referring to fig. 10 to 11, and fig. 3 to 5, a screen film 33 is sewn to the peripheral wall of the support bracket 32. The pore structure of the filter membrane 33 may be a microporous structure, and the size of the microporous structure may be selected according to actual needs. That is, the filter screen film 33 may be sewn with a film material having a microporous structure, and the filter screen film 33 is densely provided with the mesh holes 331. It will be appreciated that the microporous structure is adapted to allow blood to pass through and intercept thrombus.

As shown in fig. 3, the screen film 33 may be sewn to the inner peripheral wall of the support bracket 32. Since the support stent 32 is compressed in the outer sheath tube 1 during transportation, the screen film 33 is sewn to the inner peripheral wall of the support stent 32, and the screen film 33 can be prevented from being scratched or crushed when the support stent 32 slides in the outer sheath tube 1.

The screen film 33 may be sewn to the support bar 321 of the support bracket 32 using a wire harness. The proximal open edge of screen film 33 may be sewn to the proximal attachment point of support bracket 32. In the support bracket 32, the axial deformation amount of the support rod 321 is smaller than that of the first diamond-shaped mesh unit 310, so that the structure of the connection point of the screen film 33 and the proximal end of the support bracket 32 can be protected from breakage. A small hole 332 is arranged at the center of the far end of the filter screen film 33, and the position of the small hole 332 corresponds to the fixed ring 322.

Referring to fig. 3-5, and in combination with fig. 8 and 9, a guide head 34 is provided at the distal end of the support bracket 32. The guide head 34 may be attached to a stationary ring 322 at the distal end of the support bracket 32. The distal end of the guide head 34 is pointed for guiding the thrombolytic device and enhancing the advancement of the thrombolytic device. The guide head 34 and the center of the fixing ring 322 can be used for the guide wire to pass through, and the guide wire plays a guiding role.

Referring to fig. 12 in combination with fig. 1, the thrombolytic device comprises a delivery tube 4, an expandable thrombolytic stent 5, a drive handle 41 and a loading tube 42.

The conveying pipe 4 is movably arranged in the traction catheter 2 in a penetrating way. The delivery tube 4 is axially movable relative to the pull catheter 2 and is circumferentially rotatable relative to the pull catheter 2.

The broken bolt support 5 is arranged at the far end of the conveying pipe 4, the conveying pipe 4 can drive the broken bolt support 5 to axially move in the traction catheter 2, so that the broken bolt support 5 extends out of the far end of the traction catheter 2, the broken bolt support 5 is released in the bolt taking support 3, or the broken bolt support 5 is contracted into the traction catheter 2, and the broken bolt support 5 can be driven to completely withdraw from the traction catheter 2. Meanwhile, when the conveying pipe 4 rotates circumferentially, the broken bolt support 5 can be driven to synchronously rotate circumferentially in the bolt taking support 3 so as to cut and crush thrombus in the bolt taking support 3. Specifically, after the thrombus is cut off by the thrombus-taking stent 3 in the blood vessel, the thrombus enters into the inner space surrounded by the thrombus-taking stent 3 through the opening of the separation stent 31 in the thrombus-taking stent 3. Thereafter, the delivery tube 4 can be pushed from the proximal end of the delivery tube 4 to the distal end so that the delivery tube 4 pushes the thrombus support 5 out of the traction catheter 2, and the thrombus support 5 can be expanded circumferentially under the self elastic force due to the restriction of the traction catheter 2, so that the thrombus support 5 pulverizes thrombus inside the thrombus removal support 3.

Fig. 13 to 15 are schematic structural views of a first embodiment of the bolt-breaking bracket 5 of the present invention.

Referring to fig. 13 to 15, in combination with fig. 1, in the present embodiment, the bolt breaking bracket 5 includes a fixing tube 51, a first bracket 52, and a second bracket 53. The fixing tube 51 may be a solid rod-like structure or a frame structure, instead of a tubular structure.

The fixed pipe 51 is fixedly sleeved on the conveying pipe 4 so as to fixedly connect the bolt breaking support 5 with the conveying pipe 4. The fixing tube 51 and the conveying tube 4 can be connected and fixed in an adhesive manner, for example, medical glue or hot melt adhesive is selected for fixing.

The peripheral wall of the fixed pipe 51 is provided with an opening which is communicated with the inner cavity of the fixed pipe 51, medical glue or hot melt adhesive can partially infiltrate into the inner cavity of the fixed pipe 51 through the opening, and the fixed pipe 51 is adhered to the conveying pipe 4, so that the adhesion area between the broken bolt support 5 and the conveying pipe 4 is increased, the connection between the broken bolt support 5 and the conveying pipe 4 is firmer, and the broken bolt support 5 has better torsion resistance.

Referring to fig. 13 to 15, the first bracket 52 includes two circumferentially symmetrically distributed first cutting bars 521, and the bolt breaking bracket includes a first ring 522 disposed at a distal end of the first cutting bars 521. The proximal end of the first cutting rod 521 is attached to the fixed tube 51 and the distal end of the first cutting rod 521 is attached to the first ring 522.

The first cutting rod 521 has a variable radial dimension in a proximal-to-distal direction, and the first ring 522 is coaxially disposed with the fixed tube 51 and movably sleeved on the delivery tube 4, so that the first ring 522 can move axially relative to the fixed tube 51 and the first cutting rod 521 can be freely compressed and expanded, thereby forming the first stent 52 into a stent structure capable of being contracted and expanded in a radial direction.

When the first bracket 52 is rotated circumferentially with the fixed tube 51, the first cutting bar 521 can form a first rotational cutting curve, which can cut the thrombus. The first cutting bar 521 may be formed in a semicircular shape, a semi-elliptical shape, a V-shape, a W-shape, or the like, to form a rotational cutting curved surface of a different shape. It will be appreciated that the first cutting bar 521 may be provided in three, four or more, circumferentially spaced apart arrangements.

Referring still to fig. 13 to 15, the second support 53 includes two second cutting bars 531 symmetrically distributed in the circumferential direction, and the bolt breaking support includes a second ring 532 disposed at a distal end of the second cutting bars 531. The proximal end of the second cutting bar 531 is attached to the fixed tube 51 and the distal end of the second cutting bar 531 is attached to the second ring 532. The second cutting bars 531 and the first cutting bars 521 are disposed at staggered intervals in the circumferential direction, while the second circular rings 532 are disposed coaxially with the first circular rings 522 with intervals between the second circular rings 532 and the first circular rings 522.

The second cutting rod 531 has a variable radial dimension in a direction from the proximal end to the distal end, and the second ring 532 is movably sleeved on the delivery tube 4, so that the second ring 532 can move relative to the fixed tube 51 along the axial direction, and the second cutting rod 531 can be freely compressed and expanded, so that the second bracket 53 forms a bracket structure capable of being contracted and expanded along the radial direction. That is, one ends of the first cutting rod 521 and the second cutting rod 531 are connected to a fixing member such as the fixing tube 51, the fixing member such as the fixing tube 51 is fixedly connected to the conveying tube 4, one end of the first cutting rod 521, which is far away from the fixing tube 51, is connected to the first ring 522, one end of the second cutting rod 531, which is far away from the fixing tube 51, is connected to the second ring 532, and the first ring 522 and the second ring 532 are both slidably connected to the conveying tube 4. That is, one ends of the first bracket 52 and the second bracket 53 away from the fixing member such as the fixing tube 51 are slidably connected to the delivery tube 4.

Meanwhile, when the second holder 53 is rotated circumferentially with the fixed tube 51, the second cutting bar 531 can form a second rotating cutting curve, and the thrombus can be cut. The second cutting bar 531 may also be semicircular, semi-elliptical, V-shaped, W-shaped, etc. to form a different shape of the rotary cutting curved surface. It will be appreciated that a plurality of second cut bars 531 are also provided and are circumferentially spaced apart. And the plurality of first cutting bars 521 and the plurality of second cutting bars 531 may be arranged in a crossing or staggered interval to alternately cut the thrombus. For example, in the circumferential direction, one of the first cut bars 521, one of the second cut bars 531, the other of the first cut bars 521, and the other of the second cut bars 531 are sequentially arranged in a counterclockwise or clockwise direction.

It should be noted that, the bolt breaking bracket 5 may be integrally manufactured by using a nickel-titanium tube through a laser cutting process and a heat setting process.

Referring to fig. 13 to 15, in the present embodiment, the connection point between the second cutting bar 531 and the fixed tube 51 is located at the distal end of the connection point between the first cutting bar 521 and the fixed tube 51, while the second ring 532 is located at the proximal end of the first ring 522, and the radial dimension of the first cutting bar 521 is larger than that of the second cutting bar 531. Therefore, the second rotary cutting curved surface and the first rotary cutting curved surface are arranged at intervals inside and outside, namely the second rotary cutting curved surface is wrapped inside the first rotary cutting curved surface, and the second rotary cutting curved surface and the first rotary cutting curved surface form two layers of rotary spherical surfaces with different sizes inside and outside. The structure can enable the thrombus tissue entering the inside of the thrombus breaking bracket 5 to be cut by the first rotary cutting curved surface and the second rotary cutting curved surface in a crossing way, so that the thrombus tissue is broken to be finer.

In one embodiment, the fixing member such as the fixing tube 51 is rotatable about the rotation axis, so that the first holder is rotated to form a first rotary cutting surface and the second holder is rotated to form a second rotary cutting surface. The surface of revolution here is to be understood in a broad sense, i.e. allowing it to have a certain thickness. The maximum radial distance of the first bracket from the rotation axis is greater than the maximum radial distance of the second bracket from the rotation axis. The radial distance refers to the distance between the intersection point of the plane and the first bracket and the intersection point of the rotation axis, and the same applies to the radial distance of the second bracket.

In some embodiments, if the first bracket includes a plurality of first cutting bars 521, the plurality of first cutting bars 521 rotate about the rotation axis to form a plurality of first rotary cutting surfaces, which may or may not be coincident, depending on the respective configurations of the first cutting bars 521. For example, when a plurality of first cut bars 521 are arranged in an array around the rotation axis, i.e., the first cut bars 521 are identical in form, the first rotary cutting curved surfaces coincide; for example, when the shapes of the plurality of first cutting bars 521 are different, the first rotation cutting curved surfaces formed by the rotation of the first cutting bars 521 about the rotation axis are not completely overlapped or not overlapped.

In some embodiments, the first rotary cutting curve and the second rotary cutting curve are at least partially spaced apart. The first bracket rotates around the first rotation axis to form the first rotary cutting curved surface, and the second bracket rotates around the second rotation axis to form the second rotary cutting curved surface. When the first axis of rotation is coaxial with the second axis of rotation, it is referred to as the first rotating cutting curve and the second rotating cutting curve are coaxial. Wherein, any point on the intersection line of the plane perpendicular to the first rotation axis and the first rotary cutting curved surface, the line connected with the first rotation axis in the plane perpendicular to the first rotation axis is called one radial direction of the first rotary cutting curved surface. Similarly, any point on the intersection of a plane perpendicular to the second axis of rotation and the second curved surface of rotation, the line connecting the second axis of rotation in the plane perpendicular to the second axis of rotation is referred to as one of the radial directions of the second curved surface of rotation. The first rotary cutting curved surface and the second rotary cutting curved surface are at least partially spaced in the same vertical plane, and the vertical plane can be a plane perpendicular to the first rotation axis or a plane perpendicular to the second rotation axis.

It is understood that when the second rotary cutting curved surface is disposed at an inner and outer interval from the first rotary cutting curved surface, the first rotary cutting curved surface and the second rotary cutting curved surface have an interval.

It will be appreciated that when a portion of the second rotary cutting surface is located within the first rotary cutting surface and another portion is located outside the first rotary cutting surface, the portion of the second rotary cutting surface that intersects the first rotary cutting surface is free of spaces.

During the whole rotation of the bolt-breaking holder 5, the first holder 52 and the second holder 53 can be contracted and expanded freely. And because the first circular ring 522 at the distal end of the first bracket 52 and the second circular ring 532 at the distal end of the second bracket 53 are separated from each other and do not interfere with each other, when the first rotating cutting curved surface formed by the first bracket 52 positioned at the outer side is deformed due to the compression of thrombus in the rotating cutting process, the deformation of the first rotating cutting curved surface does not influence the second rotating cutting curved surface formed by the second bracket 53 positioned at the inner side, thereby ensuring the cutting space of the rotating cutting curved surface at the inner side, ensuring complete thrombus cutting and further improving the thrombus breaking effect.

Fig. 16 to 20 are schematic structural views of a second embodiment of the bolt-breaking bracket 5 of the present invention.

Referring to fig. 16 to 20 in combination with fig. 12, the bolt-breaking bracket 5 of the present embodiment has the same main structure as the bolt-breaking bracket 5 of the first embodiment, except that the front end of the bolt-breaking bracket 5 has a different structure.

In the thrombus support 5 of the present embodiment, the fixing tube 51 is divided into a first fixing tube 511 and a second fixing tube 512. The second fixing tube 512 is spliced at the distal end of the first fixing tube 511 along the axial direction, and the first fixing tube 511 and the second fixing tube 512 are both sleeved and fixed on the conveying tube 4. The proximal end of the first cutting rod 521 is connected to the first fixed tube 511. The proximal end of the second cutting bar 531 is connected to the second stationary tube 512.

It should be noted that the bolt breaking bracket 5 of the present embodiment may be divided into two first brackets 52 and second brackets 53 that are separated from each other. The first bracket 52 and the second bracket 53 can be manufactured by respectively adopting nickel-titanium tubes through a laser cutting process and a heat setting process, and finally are mutually spliced into a whole. The scheme can simplify the structures of the first bracket 52 and the second bracket 53 respectively, and reduce the difficulty of a laser cutting process.

In this embodiment, a clamping groove 5111 is concavely formed at the distal end of the first fixing tube 511, and a clamping protrusion 5121 adapted to the clamping groove 5111 is convexly formed at the proximal end of the second fixing tube 512. The catching protrusion 5121 is engaged with the catching groove 5111 such that the second fixing tube 512 is coaxially coupled to the distal end of the first fixing tube 511. It is understood that the clamping groove 5111 can be provided at the proximal end of the second fixing tube 512, while the clamping projection 5121 is provided at the distal end of the first fixing tube 511.

The peripheral wall of the first fixing tube 511 is provided with one or more first openings 5112, and the first openings 5112 are communicated with the lumen of the first fixing tube 511. The peripheral wall of the second fixing tube 512 is provided with one or more second openings 5122, and the second openings 5122 are communicated with the lumen of the second fixing tube 512. Glue can enter the lumen of the first fixed tube 511 through the first opening 5112 to improve the connection firmness between the first fixed tube 511 and the conveying tube 4, and can enter the lumen of the second fixed tube 512 through the second opening 5122 to improve the connection firmness between the second fixed tube 512 and the conveying tube 4.

Fig. 21 to 22 are schematic structural views of a third embodiment of the bolt-breaking bracket 5 of the present invention.

Referring to fig. 21 to 22 in combination with fig. 12, the bolt crushing bracket 5 of the present embodiment has the same main structure as the bolt crushing bracket 5 of the second embodiment, except that the structure of the distal end of the bolt crushing bracket 5 is different.

In the bolt breaking bracket 5 of the present embodiment, the first annular ring 522 at the distal end of the first bracket 52 and the second annular ring 532 at the distal end of the second bracket 53 are integrally connected, that is, the third annular ring 54 is formed. Distal ends of the first cutting bar 521 and the second cutting bar 531 are connected to the third ring 54, and the third ring 54 is movably sleeved on the delivery tube 4. Of course, the third ring 54 may be directly manufactured with separate parts instead of being fixedly connected to the first ring 522 and the second bracket 53.

In the bolt breaking support 5 of the present embodiment, the distal end of the first support 52 is connected to the distal end of the second support 53, so that the first rotating cutting curved surface formed by the first support 52 and the second rotating cutting curved surface formed by the second support 53 will have a certain influence on each other.

Fig. 23 is a schematic structural view of a fourth embodiment of the bolt-breaking bracket 5 of the present invention.

Referring to fig. 23 in combination with fig. 12, the bolt crushing bracket 5 of the present embodiment has the same main structure as the bolt crushing bracket 5 of the first embodiment, except that the proximal ends of the first bracket 52 and the second bracket 53 are different in structure.

In the thrombus support 5 of the present embodiment, the connection point of the first cut rod 521 and the fixed pipe 51 is located on the distal end side of the connection point of the second cut rod 531 and the fixed pipe 51. The distal end of the first stent is located on the distal side of the distal end of the second stent, where "distal end of the first stent" refers to the junction of the first cut rod 521 and the third ring 54 and "distal end of the second stent" refers to the junction of the second cut rod 531 and the third ring 54.

Thus, the first rotary cutting curve formed by the first cutting bar 521 and the second rotary cutting curve formed by the second cutting bar 531 are staggered at the proximal end portion. That is, the first rotary cutting curved surface and the second rotary cutting curved surface intersect. By the aid of the structural scheme, the first rotary cutting curved surface and the second rotary cutting curved surface can form a space spherical surface which is staggered with each other, and the bolt breaking effect of the bolt breaking support 5 can be improved better.

Still referring to fig. 12, the driving handle 41 is used to drive the conveying pipe 4 and the bolt breaking support 5 to rotate circumferentially. In this embodiment, the drive handle 41 is detachably provided at the proximal end of the delivery tube 4. The proximal end of the delivery tube 4 is provided with a drive terminal 401. The drive handle 41 is provided with a drive interface 411, which drive interface 411 can be docked with the drive terminal 401 of the delivery tube 4. The driving handle 41 is internally provided with a gear assembly, the driving handle 41 is also hinged with a driving spanner 412, and the driving spanner 412 is in transmission connection with the driving interface 411 through the gear assembly. Through holding the driving spanner 412 by pressure, can drive the gear assembly rotation to drive the quick rotation of driving interface 411 through gear assembly's variable speed, and then rotate through the driving terminal 401 with driving interface 411 butt joint, and then drive the garrulous bolt support 5 of the conveyer pipe 4 and the conveyer pipe 4 distal end that is connected with driving terminal 401 an organic whole and carry out quick circumference rotation, cut the thrombus tissue of parcel in getting the bolt support 3 and smash.

The thrombus-crushing support 5 rotates circumferentially inside the thrombus-taking support 3, and thus cuts and crushes thrombus tissue wrapped in the thrombus-taking support 3. By arranging the support bracket 32 to support the filter screen film 33, the filter screen film 33 can keep a stable appearance, and the support bracket 32 and the filter screen film 33 are prevented from being compressed inwards along the radial direction by extrusion of the inner wall of a blood vessel, so that the broken bolt bracket 5 is contacted with the support bracket 32 or the filter screen film 33, and the broken bolt bracket 5 is prevented from rotating along the circumferential direction in the bolt taking bracket 3. That is, the support bracket 32 needs to have a certain radial support property in addition to a certain flexibility, and a certain radial outward supporting force is provided by the support bracket 32, so that a certain interval is formed between the support bracket 32 and the bolt breaking bracket 5, or a certain interval is formed between the filter screen film 33 and the bolt breaking bracket 5.

It will be appreciated that a spring mechanism may be provided in the drive handle 41 and connected to the drive wrench 412 to allow the drive wrench 412 to rebound and reset, maintaining repeated gripping of the drive wrench 412.

Still referring to fig. 12, a loading tube 42 is movably sleeved on the conveying tube 4, and the loading tube 42 is used for loading the bolt breaking bracket 5. The loading tube 42 can be moved to the distal end of the delivery tube 4 and sleeved on the bolt breaking support 5, so that the bolt breaking support 5 is accommodated in the loading tube 42, and the first support 52 and the second support 53 can be accommodated in the loading tube 42.

When it is desired to use the thrombolytic stent 5, the loading tube 42 may be moved to the proximal end of the delivery tube 4, with the distal end of the delivery tube 4 and the thrombolytic stent 5 extending into the traction catheter 2 for use, and with the loading tube 42 residing outside the traction catheter 2.

When the bolt breaking support 5 is used, the distal end of the conveying pipe 4 and the bolt breaking support 5 can be completely withdrawn from the traction catheter 2, and the loading pipe 42 is sleeved on the bolt breaking support 5 again, so that the bolt breaking support 5 is prevented from contacting with the external environment as much as possible.

Still referring to fig. 12, the proximal end of the delivery tube 4 is further sleeved with a stainless steel tube 402. The proximal end of the delivery tube 4 is connected to the proximal end of the stainless steel tube 402. In this embodiment, a proximal end of a stainless steel tube 402 is connected to a drive terminal 401. It will be appreciated that by releasing or securing the stainless steel tube 402, the axial movement of the delivery tube 4 may be defined and controlled.

Referring to fig. 24 and 25, and referring to fig. 1, in the present embodiment, a sheath tube joint 11 is provided at a proximal end of the outer sheath tube 1, and an adjusting knob 12 is provided at a proximal end of the sheath tube joint 11. An adjustment knob 12 is rotatably connected to the proximal end of the sheath tube joint 11, and a clamp ring 13 and a silicone ring 14 are interposed between the adjustment knob 12 and the sheath tube joint 11. The silica gel ring 14 is sandwiched between the adjusting knob 12 and the clamp ring 13.

The traction catheter 2 sequentially penetrates through the adjusting knob 12, the silica gel ring 14, the compression ring 13 and the sheath tube joint 11, and further stretches into the outer sheath tube 1. The silicone ring 14 has an inner bore. The silica gel ring 14 can be extruded by rotating the adjusting knob 12, so that the inner diameter (namely the size of the inner hole) of the center of the silica gel ring 14 is changed, the traction catheter 2 can be clamped or loosened, and whether the traction catheter 2 and the outer sheath tube 1 can move relatively or not is controlled.

In the present embodiment, a branch joint 111 is further formed on the circumferential side of the sheath tube joint 11, and the branch joint 111 communicates with the inside of the clamp ring 13 and further communicates with the sheath tube joint 11 and the inside of the outer sheath tube 1. The branch joint 111 may be externally connected to the branch hose 15. The other end of the branch hose 15 may be connected to a standard luer fitting.

Referring to fig. 26 and 27, in combination with fig. 1, the suction device includes a joint guide 6 and a branch guide 61 connected to the joint guide 6.

The distal end of the connector catheter 6 is axially connected to the proximal end of the pull catheter 2. In this embodiment, the proximal end of the pull catheter 2 is provided with a fixed cap 21, and the distal end of the connector catheter 6 is threadably connected to the fixed cap 21 to communicate the connector catheter 6 with the pull catheter 2. The delivery tube 4 is movably disposed through the connector catheter 6 and the pull catheter 2, and the delivery tube 4 is capable of completely exiting the connector catheter 6 from the proximal end of the connector catheter 6.

The proximal end of the connector conduit 6 is provided with a switch for enabling on/off control of the proximal port of the connector conduit 6. The switch can close the proximal port of the connector catheter 6 after the delivery tube 4 and the thrombolytic stent 5 are completely withdrawn from the proximal end of the connector catheter 6 and completely withdrawn from the pull catheter 2 and the connector catheter 6.

In this embodiment, the switch includes a screw cap 62 and a sealing ring 63. A screw cap 62 is screwed onto the proximal end of the connector conduit 6. A sealing ring 63 is provided in the proximal port of the joint guide 6 and is sandwiched between the screw cap 62 and the proximal port of the joint guide 6. The conveying pipe 4 is movably penetrated in the spiral cover 62 and the sealing ring 63 along the axial direction, and can completely withdraw from the sealing ring 63.

The seal ring 63 has elasticity and deformability. After the conveying pipe 4 completely withdraws from the joint pipe 6 and the sealing ring 63, the sealing ring 63 is synchronously extruded or released by rotating the rotary cover 62 in the forward direction or the reverse direction so as to change the size of the center hole of the sealing ring 63. And when the central hole of the sealing ring 63 disappears due to the extrusion deformation, the proximal port of the joint guide tube 6 can be closed. When the central hole of the sealing ring 63 is present, the proximal port of the joint guide 6 can be opened. Meanwhile, when the conveying pipe 4 is penetrated into the joint guide pipe 6 and the sealing ring 63, the size of the center hole of the sealing ring 63 is changed by rotating the rotary cover 62, so that the sealing ring 63 can clamp and fix or release the conveying pipe 4, and further whether the conveying pipe 4, the joint guide pipe 6 and the traction guide pipe 2 can move relatively along the axial direction is controlled. It should be understood that the above-mentioned center hole is formed only in the sealing ring 63, and is not required to be disposed in the center of the sealing ring 63.

One end of the branch conduit 61 is connected to the peripheral wall of the joint conduit 6 and communicates with the inner cavity of the joint conduit 6, and the other end of the branch conduit 61 is used for externally connecting suction power. The external suction power can be used as the suction syringe 64, and when the proximal port of the connector catheter 6 is closed, thrombus at the proximal port of the traction catheter 2 can be collected into the suction syringe 64 through the traction catheter 2, the connector catheter 6 and the branch catheter 61 by using the suction syringe 64. The pull catheter 2 is used as a suction catheter in this case, i.e. the pull catheter 2 can also be regarded as an integral part of the suction device.

In the present embodiment, a branch pipe joint 601 communicating with the inside thereof is provided on the side wall of the joint pipe 6, and the branch pipe 61 is detachably connected to the branch pipe joint 601 to be connected to the joint pipe 6.

Referring to fig. 28 to 38, the operation of the thrombolytic system according to the present embodiment is illustrated.

Referring to fig. 28, fig. 28 shows a schematic view of a human inferior vena cava 01. Within the inferior vena cava 01 is thrombotic tissue 02. The guide wire 03 is introduced through the femoral vein or popliteal vein puncture 04 to establish a passage for venous thrombus taking.

Referring to fig. 29, the guidewire 03 is threaded through a guide head 34 at the distal end of the thrombectomy device. The thrombus taking device enters the vein 01 from the puncture 04 along the guide wire 03 and is gradually conveyed forward.

Referring to fig. 30, the thrombus removal device is advanced stepwise along the guidewire 03 until the distal end of the outer sheath 1 passes through the thrombus tissue 02.

Referring to fig. 31, the sheath connector 11 is fixed, and the traction catheter 2 and the connector catheter 6 are pushed continuously, so that the thrombus-taking stent 3 extends out of the distal end of the outer sheath 1, and the thrombus-taking stent 3 can be released gradually in the blood vessel. And stops pushing the pull catheter 2 and the connector catheter 6 when the proximal end of the thrombolytic stent 3 is fully extended out of the distal port of the outer sheath 1.

During release of the thrombolytic stent 3, the cap 62 may be released to allow axial movement of the delivery tube 4 relative to the pull catheter 2. And by pushing the delivery tube 4 distally, the distal end of the delivery tube 4 is abutted against the guide head 34 at the distal end of the thrombus taking support 3, so as to drive the thrombus taking support 3 to extend out of the outer sheath tube 1, and when the proximal end of the thrombus taking support 3 completely extends out of the distal end port of the outer sheath tube 1, the thrombus taking support 3 is completely released in a blood vessel by fixing the traction catheter 2 and the joint catheter 6 and withdrawing the delivery tube 4, and the thrombus taking support 3 is arranged in an adhesion way in the blood vessel.

During the forward pushing of the delivery tube 4, the thrombolytic stent 5 may extend out of the traction catheter 2 and into the thrombolytic stent 3. During the withdrawal of the delivery tube 4, the thrombolytic stent 5 may be forced to compress into the traction catheter 2.

It will be appreciated that the pull catheter 2 and the connector catheter 6 may also be secured, releasing the embolic stent 3 by retraction of the outer sheath 1.

Referring to fig. 32, fig. 32 is a schematic view showing the complete release of the thrombus formation 3 at the distal end of the thrombus formation 02.

Referring to fig. 33, the extraction stent 3 is driven to retract by retracting the extraction system as a whole, i.e., retracting the sheath tube 1, the traction catheter 2 and the delivery tube 4 as a whole. By using the opening and the bracket structure at the proximal end of the thrombus removing bracket 3, the thrombus tissue 02 is peeled off from the inner wall of the vein blood vessel 01 and enters the inside of the thrombus removing bracket 3 to be wrapped and collected by the filter screen film 33.

Referring to fig. 34, in combination with fig. 33, the delivery tube 4 is pushed forward to re-enter the thrombolytic stent 5 into the thrombolytic stent 3. The driving interface 411 of the driving handle 41 is in butt joint with the driving terminal 401 of the conveying pipe 4, and the driving spanner 412 is repeatedly pressed and held, so that the driving interface 411 rapidly rotates, and further the thrombus support 5 is driven to rapidly rotate, and the thrombus tissue 02 wrapped in the filter screen film 33 is cut and crushed.

Referring to fig. 35, after the thrombus is crushed, the thrombus crushing device such as the thrombus crushing bracket 5 and the conveying pipe 4 is wholly retracted to the proximal end and completely withdrawn from the proximal end of the joint pipe 6. After the broken bolt support 5 is withdrawn from the joint guide tube 6, the loading tube 42 is sleeved on the broken bolt support 5, so that the broken bolt support 5 is compressed into the loading tube 42.

Referring to fig. 36, the cap 62 at the proximal end of the connector catheter 6 is rotated to compress the inner seal 63, thereby closing the proximal end of the connector catheter 6. The aspiration syringe 64 is communicated with the branch conduit 61. By pulling the aspiration cylinder 64, the broken thrombus can be sucked into the aspiration cylinder 64 through the traction catheter 2 and the branch catheter 61 and taken out.

A branch switch 611 is provided between the suction cylinder 64 and the branch conduit 61, and the branch switch 611 is used to control whether or not the branch conduit 61 communicates with the suction cylinder 64. It will be appreciated that the branch switch 611 may also be used to control whether the branch conduit 61 is in communication with the outside.

Referring to fig. 37, the thrombus-removing holder 3 is further retracted, and the thrombus is further separated and collected in the filter membrane 33.

Referring to fig. 38, the cap 62 at the proximal end of the connector catheter 6 is rotated in the opposite direction, releasing the inner seal 63 to open the proximal end of the connector catheter 6. The broken thrombus support 5 and the conveying pipe 4 are pushed into the joint guide pipe 6 again through the loading pipe 42, and are pushed into the traction guide pipe 2 continuously, the operation of fig. 34 to 36 is repeated until thrombus tissue 02 is completely taken out of the vein 01, finally, the thrombus support 3 is contracted into the outer sheath pipe 1 through the fixing sheath pipe joint 11 by retracting the joint guide pipe 6, and the thrombus is withdrawn from the body together, so that thrombus extraction is completed.

Fig. 39 is a schematic view of a suction thrombus according to the second embodiment of the present invention.

Referring to fig. 39, in a second embodiment of the present invention, a second option of aspirating thrombi is provided.

In this embodiment, when the thrombus is broken, the entire thrombus breaking device is withdrawn from the proximal end of the connector catheter 6, a suction catheter 65 is inserted into the pull catheter 2 through the connector catheter 6 and out of the pull catheter 2, so that the distal end of the suction catheter 65 is inserted into the thrombus-taking out stent 3. The proximal end of the aspiration catheter 65 is connected to an aspiration device for performing a thrombus aspiration procedure through the distal end of the aspiration catheter 65. In this process, the pull catheter 2 is used as a channel for the suction catheter 65. Of course, in operation, the distal end of the aspiration catheter 65 does not extend into the interior of the thrombolytic stent 3, and the thrombus may be aspirated, specifically by the aspiration catheter 65 and the traction catheter 2 together. For example, when the distal end of the aspiration catheter 65 is positioned within the pull catheter 2, thrombus within the thrombolytic stent 3 enters the pull catheter 2 first and then enters the aspiration catheter 65 through the distal end of the aspiration catheter 65.

It should be noted that, during the aspiration operation, the distal end of the traction catheter 2 is connected to the proximal end of the thrombolytic stent 3, and no access to the interior of the thrombolytic stent 3 is required.

Fig. 40 and 41 are schematic structural views of a thrombus removing device according to a third embodiment of the present invention.

Referring to fig. 40 to 41, in a third embodiment of the present invention, a second connection scheme between the thrombolytic stent 3 and the traction catheter 2 in the thrombolytic device is provided, wherein the proximal end of the thrombolytic stent 3 is movably connected to the distal end of the traction catheter 2.

In this embodiment, the peripheral wall of the distal end of the traction catheter 2 is concavely provided with a chute 22, and the proximal end of the separation bracket 31 in the thrombus taking bracket 3 is movably sleeved on the chute 22, i.e. the connecting ring 313 is slidably sleeved on the chute 22. The connecting ring 313 is axially slidable within the confines of the chute 22. The connection ring 313 is provided with a pull wire 3131, and the distal end of the pull wire 3131 is connected to the connection ring 313, i.e. the pull wire 3131 is connected to the separation bracket 31. The pull wire 3131 may be used to pull the detachment bracket 31 and the entire thrombolytic bracket 3 along the chute 22 toward the proximal end of the pull catheter 2, thereby controlling the position of the distal port of the pull catheter 2 inside the thrombolytic bracket 3. The scheme structure can effectively suck the residual thrombus tissue 02 at the proximal end part of the thrombus-sucking bracket 3 in the thrombus sucking process.

Fig. 42 is a schematic structural view of a thrombolytic system according to a fourth embodiment of the present invention.

Referring to fig. 42, in a fourth embodiment of the present invention, a modification of the outer sheath 1 is provided.

In this embodiment, the outer portion of the distal end of the outer sheath 1 is provided with a compression balloon 16. Compression balloon 16 may be in communication with external high pressure equipment. When the thrombus stripping of the thrombus removing stent 3 is completed, the high-pressure equipment can inject physiological saline into the compression balloon 16, so that the compression balloon 16 is expanded and clings to the inner wall of the blood vessel. The compression sacculus 16 can effectively prevent the thrombus tissue 02 from flowing back, and enable the thrombus tissue 02 to be completely extruded into the thrombus taking support 3, so that thrombus breaking and thrombus suction are completed, and a better thrombus removing effect is achieved.

Fig. 43 is a schematic structural view of a thrombolytic system according to a fifth embodiment of the present invention.

Referring to fig. 43, in a fifth embodiment of the present invention, an integrated design of the bolt breaking device is provided. The bolt crushing device of the present embodiment differs from the first embodiment in the structure of the drive handle 41.

In the present embodiment, the drive handle 41 is integrally formed on the delivery tube 4. The proximal end of the delivery tube 4 extends through the drive handle 41. When the driving wrench 412 is held, the gear assembly in the driving handle 41 can directly drive the conveying pipe 4 to perform circumferential rotation.

Fig. 44 is a schematic view of a thrombus removal system according to a sixth embodiment of the present invention.

Referring to fig. 44, in a sixth embodiment of the present invention, an electronically controlled bolt crushing scheme is provided. The bolt crushing device of the present embodiment differs from the first embodiment in the structure of the drive handle 41.

In the present embodiment, the driving handle 41 has no driving wrench 412, and a rechargeable battery 413 and a driving motor 414 are provided inside the driving handle 41. The rechargeable battery 413 provides power to the drive motor 414, causing the drive motor 414 to rotate. The driving motor 414 can drive the gear assembly to rotate, and further drive the driving interface 411 to rotate at a high speed. The driving handle 41 is also provided with a control button 415, and the control button 415 is used for controlling the driving motor 414 to work.

Based on the technical scheme, the embodiment of the invention has at least the following advantages and positive effects:

in the thrombus taking system of the embodiment of the invention, an outer sheath tube 1 is utilized to accommodate a thrombus taking bracket 3 and a traction catheter 2; the broken bolt bracket 5 and the conveying pipe 4 can be accommodated by the traction pipe 2; the traction catheter 2, the thrombus taking bracket 3 and the outer sheath tube 1 are matched, so that thrombus in a blood vessel is accommodated in the thrombus taking bracket 3; the thrombus in the thrombus taking support 3 is cut into fine particles by utilizing the cooperation of the thrombus crushing support 5 and the conveying pipe 4, so that the thrombus crushing support 5 stretches into the thrombus taking support 3 to rotate, and the thrombus taking support is favorable for crushing refractory, larger and harder thrombus; finally, the conveying pipe 4 is utilized to drive the thrombus breaking support 5 to withdraw from the traction catheter 2, the traction catheter 2 can be used as a suction catheter at the same time, and the tiny thrombus in the thrombus taking support 3 is sucked through the inner cavity of the traction catheter 2, so that the pulmonary embolism caused by tiny thrombus omission is effectively prevented, and the thrombus taking effect is improved.

While the invention has been described with reference to several exemplary embodiments, it is to be understood that the terminology used is intended to be in the nature of words of description and of limitation. As the present invention may be embodied in several forms without departing from the spirit or essential characteristics thereof, it should also be understood that the above-described embodiments are not limited by any of the details of the foregoing description, but rather should be construed broadly within its spirit and scope as defined in the appended claims, and therefore all changes and modifications that fall within the meets and bounds of the claims, or equivalences of such meets and bounds are therefore intended to be embraced by the appended claims.

Claims

1. A thrombolytic system comprising:

the thrombus taking device is used for scraping and collecting thrombus in the blood vessel; and

a thrombus breaking device including a thrombus breaking holder for rotating within the thrombus extraction device to break thrombus collected within the thrombus extraction device;

the bolt breaking support comprises:

a fixing member;

the proximal end of the first bracket is connected with the fixing piece, and the fixing piece rotates to drive the first bracket to rotate to form a first rotary cutting curved surface for cutting the thrombus;

the proximal end of the second bracket is connected with the fixing piece, and the fixing piece rotates to drive the second bracket to rotate to form a second rotary cutting curved surface for cutting the thrombus;

The proximal end of the first bracket is positioned between two ends of the second bracket in the axial direction of the broken bolt bracket; the distal end of the second bracket is positioned between the two ends of the first bracket in the axial direction of the broken bolt bracket;

2. The embolectomy system of claim 1, wherein the second rotary cutting curve is at least partially encased within the first rotary cutting curve.

3. The embolectomy system of claim 1 wherein the anchor is rotatable about an axis of rotation, rotating the first support to form the first rotary cutting curve and rotating the second support to form the second rotary cutting curve, the first support having a maximum radial distance from the axis of rotation that is greater than a maximum radial distance from the axis of rotation.

4. The embolectomy system of claim 1, wherein the second rotating cutting curve intersects the first rotating cutting curve.

5. The embolectomy system of claim 4 wherein the junction of the first bracket and the anchor is distal to the junction of the second bracket and the anchor;

6. The embolectomy system of claim 1 wherein the thrombus reduction support comprises a first ring and a second ring, the other end of the first support being connected to the first ring, the other end of the second support being connected to the second ring.

7. The embolectomy system of claim 6 wherein the first ring and the second ring are separately disposed.

8. The embolectomy system of claim 7 wherein the second ring is positioned between the first ring and the anchor.

9. The thrombolytic system according to claim 1, wherein said thrombolytic stent comprises a third ring, and wherein the other ends of said first stent and said second stent are each connected to said third ring.

10. The embolectomy system of claim 1 wherein said first bracket is a flexible bracket, the other end of said first bracket being capable of being resiliently moved toward or away from said anchor; the second support is an elastic support, and the other end of the second support can elastically approach or depart from the fixing piece.

11. The embolectomy system of claim 1 wherein the first bracket includes a plurality of first cutting bars, one ends of the plurality of first cutting bars being connected to the securing member, and the other ends of the plurality of first cutting bars being fixedly connected;

12. The embolectomy system of claim 11, wherein the first cutting bar and the second cutting bar are staggered in the circumferential direction.

13. The embolectomy system of claim 1 wherein the anchor is a tubular structure having an inner lumen, the peripheral wall of the anchor being provided with openings in communication with the inner lumen for allowing glue to enter the inner lumen to fixedly connect the anchor and a delivery tube penetrating the inner lumen.

14. The embolectomy system of claim 1 wherein the anchor comprises a first anchor tube and a second anchor tube, the second anchor tube being attached to a distal end of the first anchor tube, the first bracket being attached to the first anchor tube, the second bracket being attached to the second anchor tube.

15. The thrombolysis system according to claim 14, wherein a distal end of said first fixed tube is concavely provided with a clamping groove, and a proximal end of said second fixed tube is convexly provided with a clamping protrusion adapted to said clamping groove; the clamping protrusion is connected in the clamping groove in a jogged mode, so that the second fixing tube is coaxially connected to the far end of the first fixing tube.

16. The embolectomy system of claim 1, comprising a delivery tube fixedly coupled to the anchor.

17. The embolectomy system of claim 16 wherein the ends of the first and second brackets distal from the anchor are each slidingly coupled to the delivery tube.

18. The thrombectomy system of claim 16, wherein the thrombectomy device further comprises a drive handle coupled to the proximal end of the delivery tube and configured to rotate the delivery tube and the thrombectomy stent in a circumferential direction.

19. The thrombolytic system according to claim 16, wherein said thrombolytic device further comprises a loading tube movably sleeved on said delivery tube; the loading tube can move to the far end of the conveying tube and is sleeved on the bolt breaking support, so that the first support and the second support are both accommodated in the loading tube.

20. The embolectomy system of claim 16 wherein said embolectomy device comprises an embolectomy stent, a traction catheter connected to said embolectomy stent, and an outer sheath, said traction catheter and said embolectomy stent slidably connected within said outer sheath, said traction catheter driving said embolectomy stent to extend or retract said outer sheath;

the thrombus taking support extends out of the outer sheath tube and is in an expansion state;

the thrombus taking support retracts into the outer sheath tube, and the thrombus taking support is in a compressed state;

the broken bolt support and the conveying pipe are both connected in the traction guide pipe in a sliding manner, and the conveying pipe drives the broken bolt support to extend out of or retract into the traction guide pipe; the broken bolt bracket extends out of the traction catheter and enters the bolt taking bracket, and the broken bolt bracket is changed from a compressed state to an expanded state;

the conveying pipe drives the broken bolt support to rotate in the bolt taking support, and the broken bolt support and the bolt taking support are spaced when rotating.