CN113713210A

CN113713210A - Multifunctional puncture treatment patch

Info

Publication number: CN113713210A
Application number: CN202111059092.7A
Authority: CN
Inventors: 肖华; 肖新民
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-09-10
Filing date: 2021-09-10
Publication date: 2021-11-30

Abstract

The invention discloses a medical product of a multi-functional puncture treatment patch, which is a bagged patch. Each bag of plaster is packaged A, B with two kinds of plaster blocks with different therapeutic effects, and the plaster blocks are adhered into a whole by plaster layers with different top, middle and bottom functions; the bottom of the sticking block is a ventilating layer, the middle part is a treatment layer, and the top is an isolation protective layer. Is characterized in that: the therapeutic effect of the patch A is that a medicament which is prepared by uniformly mixing and covering 20mg to 30mg of lidocaine, 25mg of nitroglycerin and 1.5 ml of peppermint oil on a medicine pad at the middle part of the patch A; lidocaine is used for anesthesia and pain relief, nitroglycerin expands superficial blood vessels, and peppermint oil promotes the absorption of the medicine on the epidermis; the nitroglycerin is matched with the peppermint oil to improve the one-time success rate of vascular puncture; the lidocaine enters the subcutaneous part along with the nitroglycerin for pre-anesthesia, so that the pain during puncture is relieved. The middle liner of the patch B is adhered with a gelatin sponge block which adsorbs 0.2ml of 0.25% chloramphenicol solution, so as to eliminate common symptoms of blood seepage, blood vessel drug extravasation, local infection, inflammation and red swelling. Has the outstanding advantages of simple operation, practical method, obvious medical effect and convenient use.

Description

Multifunctional puncture treatment patch

Technical Field

The invention relates to a clinical medical product, in particular to a multifunctional puncture treatment paste which is used for intradermal injection, transfusion and blood transfusion in various hospitals and physical examination departments; blood collection; percutaneous puncture intravascular catheterization; and small-area skin surgery.

Background

At present, a general blood vessel puncturing method adopted by hospitals and physical examination departments for blood vessel puncturing patient objects is an operation which is required to be completed by medical staff on the skin of a vein blood vessel of a patient object, wherein the skin of the vein blood vessel is firstly disinfected by iodophor and alcohol cotton swab, then the blood vessel puncturing is carried out through the skin, and blood sampling, intradermal injection, transfusion, blood transfusion and the like are carried out. After the operation is finished, the needle head is pulled out, the alcohol cotton swab is used for pressing the punctured needle hole, the patient object is connected with the alcohol cotton swab, the punctured needle hole is continuously pressed, and after hemostasis and no other puncture reaction exist, the whole operation process is finished.

However, since the individual physical and mental conditions of each patient are different, pain of different degrees is felt during the vascular puncture, so that mental stress is easily generated, and the puncture operation is not matched, especially for children; in addition, because the fat of the puncture part is more or the weather is cold, the blood vessel is often not obviously exposed, puncture failure is easy to happen, and multiple times of puncture operation are needed, so that the pain and the slowness of the patient are increased; meanwhile, in the conventional blood vessel puncture, many symptoms such as blood leakage at a puncture point, drug blood vessel extravasation, local redness, swelling, blood stasis, seven infection and the like easily occur, and patients with severe symptoms also have needle sickness and need additional treatment.

Disclosure of Invention

Aiming at the above adverse events possibly occurring in blood vessel puncture, in order to prevent pain, blood seepage, drug extravasation, local red swelling and infection which may occur in conventional puncture and avoid the common problems of multiple punctures due to failure of one-time puncture, the applicant develops a medical product 'a multifunctional puncture treatment patch' which is provided for departments of various hospitals, physical examinations and the like.

The multifunctional puncture treatment patch is a bagged patch, and A, B patches with different treatment effects are packaged in each bagged patch; each patch A, B is formed by sticking three adhesive layers with different functions, namely top, middle and bottom, into a whole; the bottom layers Aa and Ba of the patch A, B have air permeability and are air-permeable patches of the patch A, B; the middle adhesive layers Ab and Bb of the adhesive block A, B have treatment efficacy, are the treatment adhesive layers of the adhesive block A, B and form the structural core of the A, B adhesive block; the therapy adhesive layers Ab and Bb are adhered to the upper surfaces of the breathable adhesive layers Aa and Ba, and the base parts of the adhesive blocks A, B are formed by the therapy adhesive layers Ab and Bb; the top adhesive layers Ac and Bc of the adhesive block A, B have the functions of preventing the adhesive layer Ab and Bb from being tightly adhered to the middle treatment adhesive layers Ab and Bb and isolating the outside, and are isolation protection adhesive layers of the adhesive block A, B; the method is characterized in that: the middle treatment pasting layer Ab of the pasting block A is a medicament formed by uniformly mixing 20-30 mg of lidocaine, 25mg of nitroglycerin and 1.5 ml of peppermint oil and pasting and covering on a medicament liner of the middle treatment pasting layer Ab; the middle treatment patch Bb of the patch B is a gelatin sponge block which is stuck on a gelatin sponge liner and adsorbs chloramphenicol liquid with the concentration of 0.25 percent and the dosage of 0.2 ml.

The middle treatment pasting layer Ab of the pasting block A is pasted and covered with a medicament formed by uniformly mixing 25mg of lidocaine, 25mg of nitroglycerin and 1.5 ml of peppermint oil on a medicament liner, and the optimal treatment medicament dosage of the treatment pasting layer Ab is obtained. The patch bag comprises a patch A and a patch B, wherein the patch A is a puncture treatment patch, and the patch B is a puncture protection patch.

Firstly, the clinical application of the 'a multifunctional puncture treatment paste' in the scheme is as follows:

the usage of the patch A:

1) opening the outer packaging bag, and taking out the patch A sealed in the bag;

2) the anti-sticking isolation protection adhesive layer Ac on the top of the adhesive block A is torn off, the base part of the adhesive block A (namely the combination of the treatment adhesive layer Ab and the air-permeable adhesive layer Aa) is adhered to the skin of the blood vessel puncture area of the patient, and the puncture can be started after 10 to 20 minutes. If a catheter is left or the infusion is carried out, the patch can be continuously used according to the infusion time to maintain the effect.

The therapeutic function of the patch A is that 20mg-30mg lidocaine which has the effect of anesthesia and pain relief, 25mg nitroglycerin which has the effect of expanding superficial blood vessels, 1.5 ml of peppermint oil which has the effect of promoting the absorption of drug epidermis are arranged on the drug liner of the Ab at the middle part of the patch A, and the three drugs are matched and mutually assisted to play the effects of easily exposing and puncturing blood vessels and improving the one-time success rate of blood vessel puncture.

The medicine characteristics of the patch A are: the nitroglycerin is matched with the peppermint oil, so that local veins of arms can be quickly filled, the diameter of the veins is obviously increased, the one-time success rate of vascular puncture is easily improved, and the pain of a patient caused by multiple times of puncture is reduced; meanwhile, the lidocaine anesthesia analgesic agent enters the arm of the patient with acceleration along with the nitroglycerin vasodilator, so that the skin of the patient receives local anesthesia analgesic effect before receiving the puncture, thereby obviously relieving the pain caused by the puncture in sensation.

(II) using the paster B:

1) taking out the patch B from the outer packaging bag;

2) taking down the base part of the patch A adhered to the skin of the blood vessel puncture area of the patient object, and exposing the full vein to prepare for blood vessel puncture;

3) puncturing the vein, tearing off the anti-sticking isolation protection adhesive layer Bc on the top of the adhesive block B, attaching the base part (namely the combination of the treatment adhesive layer Bb and the ventilation adhesive layer Ba) of the adhesive block B to a puncture point, and sticking and fixing a puncture needle head, and pulling out the needle head after completing operations required to be completed, such as blood sampling, intradermal injection, transfusion, blood transfusion and the like. The process effectively eliminates the common symptoms of pain, blood seepage, blood vessel medicine leakage, local infection, redness and swelling and the like during the conventional puncture.

The therapeutic function of the patch B is that a middle therapeutic patch Bb of the patch structure is a gelatin sponge block which is stuck on a gelatin sponge liner and adsorbs chloramphenicol liquid with the concentration of 0.25 percent and the dosage of 0.2ml, and the pharmacological action of the contained chloramphenicol liquid is antibiosis and antiphlogosis; the gelatin sponge block on the pad has the following pharmacological effects: hemostasis, reduction of exudation and prevention of swelling; the gelatin sponge lining layer has the protection function of fixing the puncture needle.

The disposable patch A, B of the present case has the outstanding advantages of: the sticking block A has the functions of preventing the pain of needle insertion when puncturing the blood vessel, expanding the blood vessel to expose the epidermal blood vessel well and improving the one-time success rate of blood vessel puncture; the patch B has the functions of preventing leakage of blood vessel medicine and local hemorrhage and swelling after puncture, preventing puncture infection, fixing a needle head and protecting a puncture point.

A. The two sticking blocks B are matched for use at one time, so that the common symptoms of pain, blood seepage, blood vessel medicine leakage, local red and swollen infection and the like in the conventional puncture of a patient can be effectively eliminated.

(III) clinical application cases:

1. test subjects: 100 vascular puncture patients are taken as test subjects, and are randomly divided into a test group and a traditional conventional control group, wherein each group comprises 50 patients, the age is 16 to 72 years, the average age is 45.5 years, 80 patients are subjected to intravenous infusion, 20 patients are subjected to blood sampling, 80 patients are subjected to hand back vascular puncture, and 20 patients are subjected to antecubital fossa vascular puncture.

2. Before puncture of a test group, a patch A of the 'multifunctional puncture treatment patch' is used on the skin of a puncture part, and after 10-20 minutes, the blood vessel puncture is tried according to a conventional method; while the control group was directly operated according to the conventional vascular puncture.

3. And (3) judging the effect: (ii) analgesic effect using Visual Analogue Scale (VAS);

secondly, the puncture success rate is counted;

and thirdly, observing the local condition of the puncture part: there are bleeding (oozing and extravasated blood), red swelling and infection.

4. As a result: the test results of the test group and the control group are shown in table 1, and the patient satisfaction is shown in table 2.

Table 1: comparison of two groups of vascular puncture results

P < 0.05 compared to control (P < 0.05 means statistical results, indicating significant difference between two groups of results)

**: average Vas score

Table 2: comparison of satisfaction of two groups of patients with respect to the effect of puncturing

Compared with the control group, the compound of the formula,^＊p < 0.05(P < 0.05 means statistical results, indicating that two groups of results have significant difference compared)

Note: **: number of average rank of each

Note: satisfaction degree: patient satisfaction was set to: the score 0 is unsatisfactory, the score 1 is more satisfactory, the score 2 is satisfactory, and the score 3 is very satisfactory.

5. Complications or side effects: after the test group is pasted, 8 cases (16%) of local pruritus or heat sensation, 2 cases (4%) of allergic phenomena such as skin redness and the like do not occur, and the rest of the cases are not abnormal.

The control group had 2 cases of drug extravasation (4%), 3 cases of topical extravasation (6%), 11 cases of red and swollen puncture points (22%), and 2 cases of infection at the needle eye (4%). The local abnormalities are listed in Table 3 below.

Table 3: comparison of vascular puncture complications and drug side effects

(IV) discussion:

at present, clinical operation of diagnosis and treatment of diseases by utilizing percutaneous puncture blood vessels is widely applied at home and abroad, and although scholars continuously improve puncture methods and continuously update puncture instruments, the problems of pain, fear and the like of patients cannot be solved during operation and treatment of percutaneous puncture infusion, subcutaneous injection, intradermal injection, blood collection, percutaneous intravascular indwelling tubes and the like. Many patients often influence the effect that percutaneous puncture can be successfully used at one time due to fear of pain and mental stress and poor cooperation with medical care personnel during puncture operation.

Causes of pain in the percutaneous puncture blood vessel: firstly, the damage caused by needling skin and blood vessels; stimulation of the medicine, including chemical stimulation of temperature, medicine concentration, pH value and the like; thirdly, the medicine is externally infiltrated under the skin through the vascular puncture point. All of them can stimulate peripheral nerves to cause pain.

The patch A can enable the superficial sensory nerves of the skin to be anesthetized and the conduction of a pain reflex arc to be blocked, so that the effect of painlessness or slight pain during percutaneous blood vessel puncture is achieved, and the patch has the characteristics of strong drug penetration and quick response. Wherein the lidocaine 20mg-30mg on the Ab of the treatment paster mainly plays a role in anesthesia and analgesia, and the optimal application dose is 25 mg; the nitroglycerin 25mg plays a role in dilating skin blood vessels, the peppermint oil 1.5 ml promotes the percutaneous absorption of the medicines, and the three medicines have the action characteristics combined with the assistance of clinical time effect and can enhance the analgesic effect.

In conclusion, clinical comparative tests show that the disposable puncture patch (A, B) of the 'one-kind multifunctional puncture treatment patch' applied in the scheme is clinically used in departments such as hospital physical examination and the like, and has the outstanding advantages of simple operation, practical method, obvious medical effect, convenient use and the like.

Drawings

FIG. 1 is a schematic view of the composition and anatomy of a patch A of the present invention

FIG. 2 is a schematic view of the composition and anatomy of a patch B of the present invention

The labels in the figure are: 1 is a bottom breathable adhesive layer Aa of the adhesive block A, 2 is a middle treatment adhesive layer Ab of the adhesive block A, 2-1 is a medicine liner of the adhesive block A, 2-2 is a treatment medicine coating on the medicine liner, and 3 is an anti-sticking isolation protective layer Ac on the top of the adhesive block A; 4 is a bottom breathable adhesive layer ba of the adhesive block B, 5 is a middle treatment adhesive layer Bb of the adhesive block B, 5-1 is a gelatin sponge liner adhered with a gelatin sponge block, 5-2 is the gelatin sponge block adhered on the gelatin sponge liner and adsorbing chloramphenicol liquid, and 6 is a top anti-sticking isolation protective layer Bc of the adhesive block B.

Detailed Description

Example (c):

the product name is as follows: multifunctional puncture treatment patch

The product application is as follows: 1. intradermal injection, subcutaneous injection, infusion;

2. blood collection;

3. placing a catheter in a percutaneous puncture blood vessel;

4. small area skin surgery.

And (3) product packaging: two different small packaging bags are packaged in each packaging bag, one small packaging bag is internally and independently provided with a patch A and a bagged medicine preparation, and the other small packaging bag is internally and independently provided with a patch B and a bagged medicine preparation.

The product specification is as follows:

the patch A and the patch B in the packaging bag are all three-layer integrated therapeutic patch formed by sticking bottom breathable base cloth Aa and Ba, middle therapeutic patch layers Ab and Bb and top anti-sticking isolation protective patch layers Ac and Bc. The middle treatment adhesive layers Ab and Bb can be made into rectangular shapes or other shapes. For a patch A with a rectangular patch layer: the bottom Aa is rectangular viscous air-permeable paper or medical air-permeable gauze, and the length x width is 10cm x 8 cm; the middle treatment pasting layer Ab is a medicine pad which is pasted on the air permeable paper or the medical air permeable gauze and has the length multiplied by the width multiplied by 6cm multiplied by 4 cm; the top anti-sticking isolation protection paste layer Ac is a plastic isolation film pasted on the drug liner. For the patch B with the rectangular patch layer: the Ba at the bottom is air-permeable paper or medical air-permeable gauze with adhesive length multiplied by width multiplied by 7cm multiplied by 5 cm; the middle treatment pasting layer Bb is a gelatin sponge pad which is pasted on the air permeable paper or the medical air permeable gauze and has the length multiplied by the width multiplied by 2.5cm multiplied by 2 cm; the top anti-sticking isolation protection adhesive layer Bc is a plastic isolation film adhered on the gelatin sponge liner.

The use method of the product comprises the following steps: the big packaging bag of the multifunctional puncture treatment plaster is torn open, and two small packaging bags respectively provided with the sticking block A and the sticking block B are taken out. When the patch A, B is used, the plastic barrier films Ac, Bc on top of the A, B patch are torn away to expose the respective middle treatment patches Ab, Bb.

For the use patch a: the method comprises the steps of extruding an ointment prepared by uniformly mixing 25mg of lidocaine, 25mg of nitroglycerin and 1.5 ml of peppermint oil which are contained in a dispensing bag of a patch A, uniformly coating the ointment on a medicine liner of a treatment adhesive layer Ab, then pasting a base part (namely a combination body of the treatment adhesive layer Ab and a breathable adhesive layer Aa) of the patch A on the skin of a blood vessel puncture area of a patient subject, and puncturing after 10-20 minutes.

For the use patch B: 0.25% chloramphenicol liquid with a dose of 0.2ml in the dispensing bag of the patch B is squeezed into the gelatin sponge block on the middle gelatin sponge liner, and then the base of the patch B (i.e. the combination of the treatment patch Bb and the air-permeable patch Ba) is stuck on the puncture point to stick and fix the puncture needle. After completing the puncture operations required to be completed, such as blood sampling, intradermal injection, transfusion, blood transfusion, and the like, in the blood vessel puncture, the needle head is pulled out. The process effectively eliminates the problems of common vascular puncture complications such as pain, blood leakage, blood vessel medicine leakage, local red swelling, infection and the like during conventional puncture.

In conclusion, clinical tests show that the (A, B) patch of the disposable puncture treatment patch applied by the application has the outstanding advantages of simple operation, practical method, obvious medical effect, convenient use and the like when being used clinically in departments such as hospital physical examination and the like.

Claims

1. A multifunctional puncture therapeutic patch is a bagged patch, wherein each bagged patch is packaged with A, B patches with different therapeutic effects, and each patch A, B is composed of three patches with different functions, namely top, middle and bottom, which are adhered together; the bottom layers Aa and Ba of the patch A, B have air permeability and are air-permeable patches of the patch A, B; the middle adhesive layers Ab and Bb of the adhesive block A, B have treatment efficacy, are the treatment adhesive layers of the adhesive block A, B and form the structural core of the A, B adhesive block, and the treatment adhesive layers Ab and Bb are adhered on the air-permeable adhesive layers Aa and Ba and form the base part of the adhesive block A, B; the top adhesive layers Ac and Bc of the adhesive block A, B have the functions of preventing from being tightly adhered to the middle treatment adhesive layers Ab and Bb and isolating the outside, and are isolation protection adhesive layers of the adhesive block A, B; the method is characterized in that: the middle treatment pasting layer Ab of the pasting block A is a medicament formed by uniformly mixing 20mg-30mg of lidocaine, 25mg of nitroglycerin and 1.5 ml of peppermint oil and pasting and covering on a medicament liner of the middle treatment pasting layer Ab; the middle treatment patch Bb of the patch B is a gelatin sponge block which is stuck on a gelatin sponge liner and adsorbs chloramphenicol liquid with the concentration of 0.25 percent and the dosage of 0.2 ml.

2. The patch of claim 1, wherein: the middle treatment pasting layer Ab of the pasting block A is pasted and covered with a medicament formed by uniformly mixing 25mg of lidocaine, 25mg of nitroglycerin and 1.5 ml of peppermint oil on a medicament liner, and the optimal treatment medicament dosage of the treatment pasting layer Ab is obtained.