CN113633740A - Traditional Chinese medicine composition, traditional Chinese medicine preparation and traditional Chinese medicine product for treating breast nodules - Google Patents
Traditional Chinese medicine composition, traditional Chinese medicine preparation and traditional Chinese medicine product for treating breast nodules Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition, a traditional Chinese medicine preparation and a traditional Chinese medicine product for treating breast nodules. The traditional Chinese medicine composition comprises the following components in parts by weight: taking 10 parts by weight of radix bupleuri as a reference, 2-25 parts by weight of radix curcumae, 6-30 parts by weight of safflower, 2-25 parts by weight of thunberg fritillary bulb, 2-25 parts by weight of curcuma zedoary, 2-25 parts by weight of cowherb seed, 4-30 parts by weight of angelica sinensis, 4-30 parts by weight of herba lycopi, 4-40 parts by weight of stiff silkworm, 2-25 parts by weight of solanum lyratum, 2-40 parts by weight of edible tulip, 4-40 parts by weight of selfheal, 2-15 parts by weight of spina gleditsiae, 2-25 parts by weight of dandelion, 2-40 parts by weight of oyster and 4-25 parts by weight of rhizoma cyperi. When the medicines of the traditional Chinese medicine composition are used together, monarch, minister, assistant and guide compatibility is carried out, and the effects of soothing liver, regulating qi, promoting blood circulation, reducing phlegm, softening hardness and dissipating stagnation can be achieved, so that the breast nodules are effectively treated.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition, a traditional Chinese medicine preparation and a traditional Chinese medicine product for treating breast nodules.
Background
The breast nodules are common female gynopathy, namely hyperplasia diseases of the breast, are degenerative changes of structures of mammary tissue ducts and breast lobules and growth of progressive connective tissues, and the pathogenesis of the breast nodules is mainly due to endocrine hormone imbalance. The symptoms of the breast nodule mainly include breast distending pain, stabbing pain, traction pain, breast lumps, nodules and cords, and the symptoms of the breast nodule also include long course of disease, slow development, nipple discharge and the like, and are mostly changed due to mood changes before and after the menstrual period. The pain before menstruation is aggravated, the pain after menstruation is reduced or disappeared, and the pain after menstruation is persistent in severe cases. At present, 70% -80% of women have breast nodules, and if the breast nodules are not treated in time or are not cured for a long time, benign tumors and malignant lesions of the breast can occur.
Modern medicine considers marriage and breeding, diet, human living environment and genetic factors as main causes of mammary gland diseases, at present, the treatment is generally carried out by methods such as massage, hormone therapy or oral administration of antibiotic drugs, but although drugs such as hormone and chemical can soften nodules and relieve pain, endocrine dyscrasia in the body of a patient can be caused by long-term administration, and the side effect is great. Although the clinical reports are more at present, a plurality of Chinese medicinal treatment compositions are published in the world, but the curative effect is not stable and is not ideal.
Disclosure of Invention
The invention aims to overcome the problems of unstable curative effect and unobvious effect of the prior art for treating the breast nodules, and provides a traditional Chinese medicine composition, a traditional Chinese medicine preparation and a traditional Chinese medicine product for treating the breast nodules.
In order to achieve the above object, the first aspect of the present invention provides a traditional Chinese medicine composition for treating breast nodules, which comprises the following components in parts by weight: taking 10 parts by weight of radix bupleuri as a reference, 2-25 parts by weight of radix curcumae, 6-30 parts by weight of safflower, 2-25 parts by weight of thunberg fritillary bulb, 2-25 parts by weight of curcuma zedoary, 2-25 parts by weight of cowherb seed, 4-30 parts by weight of angelica sinensis, 4-30 parts by weight of herba lycopi, 4-40 parts by weight of stiff silkworm, 2-25 parts by weight of solanum lyratum, 2-40 parts by weight of edible tulip, 4-40 parts by weight of selfheal, 2-15 parts by weight of spina gleditsiae, 2-25 parts by weight of dandelion, 2-40 parts by weight of oyster and 4-25 parts by weight of rhizoma cyperi.
Preferably, based on 10 parts by weight of the bupleurum falcatum, the content of the curcuma aromatica is 5-20 parts by weight, the content of the safflower is 10-20 parts by weight, the content of the thunberg fritillary bulb is 5-20 parts by weight, the content of the curcuma zedoary is 5-15 parts by weight, the content of the cowherb seed is 5-20 parts by weight, the content of the angelica sinensis is 5-20 parts by weight, the content of the eupatorium japonicum is 5-20 parts by weight, the content of the stiff silkworm is 10-30 parts by weight, the content of the solanum lyratum thunb is 5-20 parts by weight, the content of the edible tulip is 5-30 parts by weight, the content of the selfheal is 10-30 parts by weight, the content of the spina gleditsiae is 5-10 parts by weight, the content of the dandelion is 5-20 parts by weight, the content of the oyster is 5-30 parts by weight, the content of the rhizoma cyperi is 10 to 20 weight parts.
The second aspect of the invention provides a preparation method of a traditional Chinese medicine preparation for treating breast nodules, which comprises the following steps:
(1) mixing bupleuri radix, radix Curcumae, Carthami flos, Bulbus Fritillariae Thunbergii, Curcumae rhizoma, semen Vaccariae, radix Angelicae sinensis, herba Lycopi, Bombyx Batryticatus, herba Solani Lyrati, Pseudobulbus Cremastrae seu pleiones, Prunellae Spica, spina Gleditsiae, herba Taraxaci, Concha Ostreae, and rhizoma Cyperi with water, decocting, and filtering to obtain water extract;
(2) processing the water extract to obtain the traditional Chinese medicine preparation;
wherein, based on 10 weight parts of the bupleurum falcatum, the content of the curcuma aromatica is 2-25 weight parts, the content of the safflower is 6-30 weight parts, the content of the thunberg fritillary bulb is 2-25 weight parts, the content of the curcuma zedoary is 2-25 weight parts, the content of the cowherb seed is 2-25 weight parts, the content of the angelica sinensis is 4-30 weight parts, the content of the eupatorium japonicum is 4-30 weight parts, the content of the stiff silkworm is 4-40 weight parts, the content of the solanum lyratum is 2-25 weight parts, the content of the edible tulip is 2-40 weight parts, the content of the selfheal is 4-40 weight parts, the content of the spina gleditsiae is 2-15 weight parts, the content of the dandelion is 2-25 weight parts, and the content of the oyster is 2-40 weight parts, the content of the rhizoma cyperi is 4 to 25 weight parts.
Preferably, based on 10 parts by weight of the bupleurum falcatum, the content of the curcuma aromatica is 5-20 parts by weight, the content of the safflower is 10-20 parts by weight, the content of the thunberg fritillary bulb is 5-20 parts by weight, the content of the curcuma zedoary is 5-15 parts by weight, the content of the cowherb seed is 5-20 parts by weight, the content of the angelica sinensis is 5-20 parts by weight, the content of the eupatorium japonicum is 5-20 parts by weight, the content of the stiff silkworm is 10-30 parts by weight, the content of the solanum lyratum thunb is 5-20 parts by weight, the content of the edible tulip is 5-30 parts by weight, the content of the selfheal is 10-30 parts by weight, the content of the spina gleditsiae is 5-10 parts by weight, the content of the dandelion is 5-20 parts by weight, the content of the oyster is 5-30 parts by weight, the content of the rhizoma cyperi is 10 to 20 weight parts.
Preferably, in step (1), the number of times of decoction is 2-4, and the filtrates obtained by filtering after each decoction are combined to obtain the water extract.
Preferably, the weight ratio of the total weight of the traditional Chinese medicine raw materials to the water in each decocting process is 1: 3-8.
Preferably, the conditions of the decoction at least satisfy: the decocting temperature is 100-.
Preferably, in step (2), the formulation treatment comprises: drying the water extract, pulverizing, sieving, and sterilizing the undersize product.
Preferably, the screened mesh is a 150-200 mesh screen.
Preferably, the conditions of sterilization are at least: the temperature is 110-125 ℃, and the time is 20-90 min.
In a third aspect, the present invention provides a Chinese medicinal preparation prepared by the above preparation method.
The invention provides a traditional Chinese medicine product for treating breast nodules, which contains the traditional Chinese medicine composition or the traditional Chinese medicine preparation prepared by the preparation method.
Through the technical scheme, the invention has the beneficial effects that:
the traditional Chinese medicine composition for treating breast nodules provided by the invention is scientific and excellent in formula, and the radix bupleuri is a monarch drug for soothing liver-qi stagnation; the radix curcumae has the effects of activating blood and relieving pain, promoting qi circulation and relieving depression, the safflower has the effects of activating blood and stimulating the menstrual flow, dissipating blood stasis and relieving pain, the thunberg fritillary bulb has the effects of clearing heat and reducing phlegm, and eliminating stagnation and carbuncle, and the radix curcumae, the safflower and the fritillary bulb are used as ministerial drugs; the zedoary has the effects of promoting qi circulation, removing blood stasis, resolving food stagnation and relieving pain, the cowherb seed has the effects of promoting blood circulation, stimulating the menstrual flow, promoting lactation and eliminating carbuncle, the Chinese angelica has the effects of enriching blood, promoting blood circulation, regulating menstruation and relieving pain, the herba lycopi has the effects of promoting blood circulation, regulating menstruation, removing blood stasis and eliminating carbuncle, and the four medicines are used together to enhance the effects of promoting blood circulation and removing blood stasis; bombyx Batryticatus has effects of eliminating phlegm and resolving masses, and enhancing the effects of eliminating phlegm and resolving masses; the bittersweet herb has the functions of clearing away heat and toxic materials, promoting diuresis and reducing swelling, the edible tulip has the functions of clearing away heat and toxic materials, eliminating carbuncle and dissipating binds, the common selfheal fruit-spike has the functions of clearing away heat and purging fire, dissipating binds and reducing swelling, the Chinese honeylocust spine has the functions of reducing swelling and expelling toxin and discharging pus, the dandelion has the functions of clearing away heat and toxic materials, the oyster has the functions of softening and dissipating binds and enhancing the functions of softening and dissipating binds. The general domination of qi diseases and the general commander of women's nutgrass galingale rhizome are used as guiding drugs for soothing liver and relieving depression, regulating menstruation and relieving pain, and are used as qi-blood-dividing drugs. The traditional Chinese medicine composition has the effects of coordinating qi and blood, treating both manifestation and root cause of disease, soothing liver, regulating qi, promoting blood circulation, eliminating phlegm, softening hardness and dissipating stagnation. Has the advantages of quick response, high curative effect, high cure rate, low recurrence rate, safety and reliability.
The preparation method of the traditional Chinese medicine preparation for treating the breast nodules, provided by the invention, is simple in process, is more beneficial to preparing the medicine for treating the breast nodules, and can effectively reduce the production cost of the medicine.
Detailed Description
The endpoints of the ranges and any values disclosed herein are not limited to the precise range or value, and such ranges or values should be understood to encompass values close to those ranges or values. For ranges of values, between the endpoints of each of the ranges and the individual points, and between the individual points may be combined with each other to give one or more new ranges of values, and these ranges of values should be considered as specifically disclosed herein.
The invention provides a traditional Chinese medicine composition for treating breast nodules, which comprises the following components in parts by weight: taking 10 parts by weight of radix bupleuri as a reference, 2-25 parts by weight of radix curcumae, 6-30 parts by weight of safflower, 2-25 parts by weight of thunberg fritillary bulb, 2-25 parts by weight of curcuma zedoary, 2-25 parts by weight of cowherb seed, 4-30 parts by weight of angelica sinensis, 4-30 parts by weight of herba lycopi, 4-40 parts by weight of stiff silkworm, 2-25 parts by weight of solanum lyratum, 2-40 parts by weight of edible tulip, 4-40 parts by weight of selfheal, 2-15 parts by weight of spina gleditsiae, 2-25 parts by weight of dandelion, 2-40 parts by weight of oyster and 4-25 parts by weight of rhizoma cyperi.
The pharmacological analysis of the selected traditional Chinese medicine raw materials:
bupleurum root: is dried root of Bupleurum chinense DC or Bupleurum scorzonerifolium Willd of Umbelliferae, has bitter taste and slightly cold nature, enters liver and gallbladder channels, and has effects of relieving exterior and interior syndrome, dispersing stagnated liver qi, relieving qi stagnation, invigorating yang, lifting subsidence, clearing away heat, and preventing malaria;
turmeric root-tuber: is dried root tuber of Curcuma wenyuma RC Yujin Y, H.Chenet C.Ling, Curcuma rhizome Curcuma longa LongaL, Curcuma kwangwangsiensis S.G.Lee et C.F.Liang or Curcuma zedoaria Curcuma phaeocauli Val, has pungent, bitter and cold properties, enters liver, heart and lung channels, and has the effects of activating blood, relieving pain, promoting qi circulation, relieving depression, clearing heart, cooling blood, benefiting gallbladder and removing jaundice.
Safflower: is dried flower of Carthamus tinctorius L. of Compositae, with pungent taste and warm nature, and enters heart and liver meridians. Has effects in promoting blood circulation, dredging channels, removing blood stasis, and relieving pain;
thunberg fritillary bulb: is a dry bulb of Fritillaria thunbergii Miq. of Liliaceae, has bitter taste and cold property, enters lung and heart channels, and has the effects of clearing heat, resolving masses, eliminating phlegm and relieving cough;
zedoary turmeric: is the rhizome of Curcuma zedoaria currinosa Roxb of Zingiberaceae, C.zedoaria non Rosc, Curcuma kwangsiensis S.G.Lee et C.F.Liang and Curcuma wenyujin Y.H.Chen et C.Ling, is pungent, bitter and warm in taste, belongs to liver and spleen channels, and has the effects of promoting the circulation of qi and blood, removing food retention and relieving pain;
seed of cowherb: is dried mature seed of Garcke of Caryophyllaceae, Vaccaria segetalis (Neock), has bitter taste and mild nature, enters liver and stomach channels, and has effects of promoting blood circulation, dredging channels, promoting lactation, relieving swelling, inducing diuresis, and treating stranguria;
chinese angelica: is dried root of Angelica sinensis (Oliv.) Diels) of Umbelliferae, has sweet and pungent taste, warm nature, and effects of tonifying blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel, and relieving constipation;
herba lycopi: is dried aerial parts of Lycopus lucidus Turcz. vat. hirtus Regel of Labiatae, bitter, pungent and slightly warm, and enters liver and spleen channels, and has effects of promoting blood circulation, regulating menstruation, removing blood stasis, resolving carbuncle, inducing diuresis and relieving swelling;
stiff silkworm: is a dry body which is lethal when larva of silkworm of bombyx mori, i.e. silkworm, is infected with Beauveria bassiana (balss) Vuillant, and has the effects of dispelling wind, arresting convulsion, reducing phlegm and resolving masses;
white English: is a solanaceae herbaceous vine, takes whole grass and roots as medicines, is bitter, slightly cold and toxic, enters liver and stomach channels, and has the effects of clearing away heat and toxic materials, promoting diuresis and reducing swelling;
and (3) edible tulip: is dry pseudobulb of Cremastra aphani appendiculata (D.Don) Makino, Pleione bulbocodioides (Franch.) Rolfe or Pleione yunnanensis Rolfe of Pleione yunnanensis of Orchidaceae, is sweet in taste, slightly pungent and cool in nature, and has the effects of clearing away heat and toxic materials, eliminating carbuncle and resolving hard mass;
selfheal: is dry cluster of Prunellae Spica Prunella vulgaris L. of Labiatae, pungent, bitter and cold, and enters liver and gallbladder channels, and has effects of clearing pathogenic fire, improving eyesight, resolving hard mass and relieving swelling;
spina gleditsiae: is dry thorn of Gleditsia sinensis Lam. of Leguminosae, with pungent taste and warm nature, and has effects of relieving swelling, removing toxic substance, expelling pus, and killing parasite;
dandelion: the taraxacum perennial herb of Compositae has bitter and sweet taste, cold nature, and liver and stomach meridians entering, and has effects of clearing away heat and toxic materials, promoting urination and resolving hard mass;
oyster shell: is the shell of Ostrea gigas Thunb, Ostrea gigas Thunb or Ostrea gigas Thunb of Ostreidae, has salty and damp taste, cold nature, and can enter liver and kidney channels, and has effects of nourishing yin, suppressing yang, softening and resolving hard mass, and astringing;
rhizoma cyperi: is the dried rhizome of Cyperus rotundus L.of Cyperaceae, is pungent, slightly bitter, slightly sweet, and flat, and enters liver, spleen, and triple energizer meridians, and has effects of activating qi-flowing, resolving stagnation, regulating menstruation, and relieving pain.
The inventor finds that the raw material composition can sooth the liver, regulate qi, promote blood circulation, reduce phlegm, soften hardness, dissipate stagnation, is good at qi and blood synchronization, treats both principal and secondary aspects of diseases, has the advantages of attacking evil without damaging vital qi, and has the advantages of quick response, high curative effect, high cure rate, lower recurrence rate, safety and reliability.
In order to further improve the compatibility effect, preferably, based on 10 parts by weight of the bupleurum falcatum, the content of the curcuma aromatica is 5-20 parts by weight, the content of the safflower is 10-20 parts by weight, the content of the thunberg fritillary bulb is 5-20 parts by weight, the content of the curcuma zedoary is 5-15 parts by weight, the content of the cowherb seed is 5-20 parts by weight, the content of the angelica sinensis is 5-20 parts by weight, the content of the eupatorium japonicum is 5-20 parts by weight, the content of the stiff silkworm is 10-30 parts by weight, the content of the solanum lyratum is 5-20 parts by weight, the content of the edible tulip is 5-30 parts by weight, the content of the selfheal is 10-30 parts by weight, the content of the spina gleditsiae is 5-10 parts by weight, and the content of the dandelion is 5-20 parts by weight, the content of the oyster is 5-30 parts by weight, and the content of the rhizoma cyperi is 10-20 parts by weight.
The second aspect of the invention provides a preparation method of a traditional Chinese medicine preparation for treating breast nodules, which comprises the following steps:
(1) mixing bupleuri radix, radix Curcumae, Carthami flos, Bulbus Fritillariae Thunbergii, Curcumae rhizoma, semen Vaccariae, radix Angelicae sinensis, herba Lycopi, Bombyx Batryticatus, herba Solani Lyrati, Pseudobulbus Cremastrae seu pleiones, Prunellae Spica, spina Gleditsiae, herba Taraxaci, Concha Ostreae, and rhizoma Cyperi with water, decocting, and filtering to obtain water extract;
(2) processing the water extract to obtain the traditional Chinese medicine preparation;
wherein, based on 10 weight parts of the bupleurum falcatum, the content of the curcuma aromatica is 2-25 weight parts, the content of the safflower is 6-30 weight parts, the content of the thunberg fritillary bulb is 2-25 weight parts, the content of the curcuma zedoary is 2-25 weight parts, the content of the cowherb seed is 2-25 weight parts, the content of the angelica sinensis is 4-30 weight parts, the content of the eupatorium japonicum is 4-30 weight parts, the content of the stiff silkworm is 4-40 weight parts, the content of the solanum lyratum is 2-25 weight parts, the content of the edible tulip is 2-40 weight parts, the content of the selfheal is 4-40 weight parts, the content of the spina gleditsiae is 2-15 weight parts, the content of the dandelion is 2-25 weight parts, and the content of the oyster is 2-40 weight parts, the content of the rhizoma cyperi is 4 to 25 weight parts.
According to the invention, the modes and equipment for decoction, filtration and preparation treatment are not particularly limited, the decoction can adopt any one of the decoction modes disclosed in the prior art, the total mass of the traditional Chinese medicine raw materials and water can be determined by a person skilled in the art according to actual conditions, and the decoction time can also be determined by the person skilled in the art according to actual conditions. The filtration can be filter pressing, suction filtration or other modes, preferably a mode of screen filtration, and the screen is preferably 100-200 meshes. The preparation treatment can be any feasible preparation mode disclosed in the prior art, for example, the auxiliary materials used for preparing the oral liquid in the field are added into the water extract to prepare the oral liquid, or the water extract is dried, and then the dried solid is mixed with the corresponding auxiliary materials to prepare powder, tablets, granules or capsules.
In order to further improve the treatment effect of the prepared traditional Chinese medicine preparation on treating breast nodules, preferably, 10 parts by weight of the bupleurum root is taken as a reference, 5-20 parts by weight of the curcuma aromatica, 10-20 parts by weight of the safflower, 5-20 parts by weight of the thunberg fritillary bulb, 5-15 parts by weight of the curcuma zedoary, 5-20 parts by weight of the cowherb seed, 5-20 parts by weight of the angelica sinensis, 5-20 parts by weight of the eupatorium japonicum, 10-30 parts by weight of the stiff silkworm, 5-20 parts by weight of the solanum lyratum, 5-30 parts by weight of the edible tulip, 10-30 parts by weight of the selfheal and 5-10 parts by weight of the spina gleditsiae, the dandelion is 5-20 parts by weight, the oyster is 5-30 parts by weight, and the rhizoma cyperi is 10-20 parts by weight.
In order to further improve the treatment effect of the prepared traditional Chinese medicine preparation on treating breast nodules, preferably, in the step (1), the decocting times are 2-4 times, and the filtrates obtained by filtering after each decocting are combined to obtain the water extract.
In order to further improve the treatment effect of the prepared traditional Chinese medicine preparation on treating breast nodules, the weight ratio of the total weight of the traditional Chinese medicine raw materials to water is preferably 1:3-8 in each decocting process. The inventors have found that, in this preferred embodiment, the concentration of the active ingredient in the aqueous extract can be further increased.
In order to further improve the treatment effect of the prepared traditional Chinese medicine preparation on treating the breast nodules, preferably, the decocting conditions at least meet the following requirements: the decocting temperature is 100-; the decoction time is 1-4h, and specifically 1h, 2h, 3h, 4h, or any value between any two of the above values. The inventor finds that under the preferred embodiment, the scheme of the invention has the advantages of further improving the extraction efficiency of the effective components in the raw materials, thereby improving the treatment effect of the prepared traditional Chinese medicine preparation on treating the breast nodules.
In order to further improve the treatment effect of the prepared traditional Chinese medicine preparation in treating the breast nodules, preferably, in the step (2), the preparation is processed by: drying the water extract, pulverizing, sieving, and sterilizing the undersize product. The inventor finds that the sterilization effect can be improved by performing disinfection and sterilization after water extraction, drying, crushing and sieving, and further improves the treatment effect of the prepared traditional Chinese medicine preparation on the breast nodules.
Wherein, the manner and equipment of drying, pulverizing and sieving are not particularly limited. The drying mode can adopt air-blast drying, high-temperature drying or infrared drying. The crushing mode can be mechanical grinding or manual grinding. The drying conditions at least satisfy: the temperature is 60-80 ℃ and the time is 24-72 h.
According to the invention, the sieved screen is a 150-200 mesh screen.
The sterilization mode can adopt any one of the sterilization modes disclosed in the prior art, and can adopt a soaking sterilization method, a wet heat sterilization method, a dry heat sterilization method, an ozone sterilization method or other feasible sterilization methods. In order to further improve the sterilization effect, it is preferable that the sterilization conditions at least satisfy: the temperature is 110-125 ℃, and the time is 20-90 min.
In a third aspect, the present invention provides a Chinese medicinal preparation prepared by the above preparation method.
The invention provides a traditional Chinese medicine product for treating breast nodules, and the traditional Chinese medicine product contains the traditional Chinese medicine composition or the traditional Chinese medicine preparation prepared by the preparation method.
Preferably, the dosage form of the traditional Chinese medicine product is decoction, mixture, oral liquid, granules, pills, tablets and capsules. The traditional Chinese medicine product is prepared from the traditional Chinese medicine composition or the traditional Chinese medicine preparation and conventional auxiliary materials into decoction, mixture, oral liquid, granules, pills, tablets and capsules. The above mentioned conventional adjuvants are different adjuvants disclosed in the field of Chinese medicine for preparing different dosage forms.
The present invention will be described in detail below by way of examples.
In the following examples, bupleurum, curcuma aromatica, safflower, thunberg fritillary bulb, curcuma zedoary, cowherb seed, angelica, eupatorium japonicum, stiff silkworm, solanum lyratum thunb, edible tulip, selfheal, spina gleditsiae, dandelion, oyster, rhizoma cyperi, selfheal, ternate buttercup root, garden balsam stem, rose and dried orange peel are all conventional products sold in the market.
Example 1
(1) Mixing 100g of radix bupleuri, 100g of radix curcumae, 120g of safflower, 100g of thunberg fritillary bulb, 100g of curcuma zedoary, 100g of cowherb seed, 160g of angelica, 150g of herba lycopi, 160g of stiff silkworm, 100g of solanum lyratum thunb, 160g of edible tulip, 160g of selfheal, 60g of spina gleditsiae, 100g of dandelion, 160g of oyster and 150g of rhizoma cyperi with water which is 5 times of the total amount of the traditional Chinese medicine raw materials, decocting for 3 hours at the temperature of 110 ℃, and filtering by a 150-mesh screen to obtain a first filtrate and first herb residue; adding 5 times of water into the first residue, decocting at 110 deg.C for 2 hr, and filtering with 150 mesh sieve to obtain second filtrate and second residue; adding 5 times of water into the second residue, decocting at 110 deg.C for 2 hr, filtering with 150 mesh sieve to obtain third filtrate, and mixing the third filtrates to obtain water extract;
(2) drying the water extract, pulverizing, sieving with 200 mesh sieve, and sterilizing the undersize product at 70 deg.C for 48h to obtain the Chinese medicinal preparation.
Example 2
(1) Mixing 100g of radix bupleuri, 50g of radix curcumae, 100g of safflower, 50g of thunberg fritillary bulb, 50g of rhizoma zedoariae, 50g of cowherb seed, 50g of angelica, 50g of herba lycopi, 100g of stiff silkworm, 50g of solanum lyratum thunb, 50g of edible tulip, 100g of selfheal, 50g of spina gleditsiae, 50g of dandelion, 50g of oyster and 100g of rhizoma cyperi with 3 times of water of the total amount of the traditional Chinese medicine raw materials, decocting for 4 hours at the temperature of 100 ℃, and filtering by a 200-mesh screen to obtain a first filtrate and first herb residue; adding 3 times of water into the first residue, decocting at 100 deg.C for 1 hr, and filtering with 200 mesh screen to obtain second filtrate and second residue; adding 3 times of water into the second residue, decocting at 100 deg.C for 1 hr, filtering with 200 mesh sieve to obtain third filtrate and third residue, adding 3 times of water into the third residue, decocting at 100 deg.C for 1 hr, filtering with 200 mesh sieve to obtain fourth filtrate, and mixing the filtrates to obtain water extract;
(2) drying the water extract, pulverizing, sieving with 150 mesh sieve, and sterilizing the undersize product at 60 deg.C for 72h to obtain the Chinese medicinal preparation.
Example 3
(1) Mixing 100g of radix bupleuri, 200g of radix curcumae, 200g of safflower, 200g of thunberg fritillary bulb, 150g of rhizoma zedoariae, 200g of cowherb seed, 200g of angelica, 200g of herba lycopi, 300g of stiff silkworm, 200g of solanum lyratum thunb, 300g of edible tulip, 300g of selfheal, 100g of spina gleditsiae, 200g of dandelion, 300g of oyster and 200g of rhizoma cyperi with water which is 8 times of the total amount of the traditional Chinese medicine raw materials, decocting for 3 hours at the temperature of 120 ℃, and filtering by using a 100-mesh screen to obtain a first filtrate and a first herb residue; adding water 8 times the amount of the above Chinese medicinal materials into the first residue, decocting at 120 deg.C for 2 hr, filtering with 100 mesh sieve to obtain second filtrate, and mixing the two filtrates to obtain water extract;
(2) drying the water extract, pulverizing, sieving with 200 mesh sieve, and sterilizing the undersize product at 80 deg.C for 24 hr to obtain the Chinese medicinal preparation.
Example 4
(1) Mixing 100g of radix bupleuri, 20g of radix curcumae, 60g of safflower, 20g of thunberg fritillary bulb, 20g of rhizoma zedoariae, 20g of cowherb seed, 40g of Chinese angelica, 40g of herba lycopi, 40g of stiff silkworm, 20g of solanum lyratum thunb, 20g of edible tulip, 40g of selfheal, 20g of spina gleditsiae, 20g of dandelion, 20g of oyster and 40g of rhizoma cyperi with 3 times of water of the total amount of the traditional Chinese medicine raw materials, decocting for 4 hours at the temperature of 100 ℃, and filtering by a 200-mesh screen to obtain a first filtrate and first herb residue; adding 3 times of water into the first residue, decocting at 100 deg.C for 1 hr, and filtering with 200 mesh screen to obtain second filtrate and second residue; adding 3 times of water into the second residue, decocting at 100 deg.C for 1 hr, filtering with 200 mesh sieve to obtain third filtrate and third residue, adding 3 times of water into the third residue, decocting at 100 deg.C for 1 hr, filtering with 200 mesh sieve to obtain fourth filtrate, and mixing the filtrates to obtain water extract;
(2) drying the water extract, pulverizing, sieving with 150 mesh sieve, and sterilizing the undersize product at 60 deg.C for 72h to obtain the Chinese medicinal preparation.
Example 5
(1) Mixing 100g of radix bupleuri, 250g of radix curcumae, 300g of safflower, 250g of thunberg fritillary bulb, 250g of rhizoma zedoariae, 250g of cowherb seed, 300g of angelica, 300g of herba lycopi, 400g of stiff silkworm, 250g of solanum lyratum thunb, 400g of edible tulip, 400g of selfheal, 150g of spina gleditsiae, 250g of dandelion, 400g of oyster and 250g of rhizoma cyperi with water which is 8 times of the total amount of the traditional Chinese medicine raw materials, decocting for 3 hours at the temperature of 120 ℃, and filtering by using a 100-mesh screen to obtain a first filtrate and first herb residue; adding water 8 times the amount of the above Chinese medicinal materials into the first residue, decocting at 120 deg.C for 2 hr, filtering with 100 mesh sieve to obtain second filtrate, and mixing the two filtrates to obtain water extract;
(2) drying the water extract, pulverizing, sieving with 200 mesh sieve, and sterilizing the undersize product at 80 deg.C for 24 hr to obtain the Chinese medicinal preparation.
Comparative example 1
(1) Mixing 100g of radix bupleuri, 250g of radix curcumae, 300g of safflower, 250g of thunberg fritillary bulb, 250g of rhizoma zedoariae, 250g of cowherb seed, 300g of angelica, 400g of stiff silkworm, 400g of Indian iphigenia bulb, 400g of selfheal, 150g of spina gleditsiae and 400g of oyster with water which is 8 times of the total amount of the traditional Chinese medicine raw materials, decocting for 3 hours at the temperature of 120 ℃, and filtering by using a 100-mesh screen to obtain a first filtrate and a first medicine residue; adding water 8 times the amount of the above Chinese medicinal materials into the first residue, decocting at 120 deg.C for 2 hr, filtering with 100 mesh sieve to obtain second filtrate, and mixing the two filtrates to obtain water extract;
(2) drying the water extract, pulverizing, sieving with 200 mesh sieve, and sterilizing the undersize product at 80 deg.C for 24 hr to obtain the Chinese medicinal preparation.
Comparative example 2
(1) Mixing 100g of edible tulip, 100g of selfheal, 100g of oyster, 100g of cat scratch, 200g of stiff silkworm, 200g of garden balsam, 200g of rose and 300g of dried orange peel with water which is 8 times of the total amount of the traditional Chinese medicine raw materials, decocting for 3 hours at the temperature of 120 ℃, and filtering by using a 100-mesh screen to obtain a first filtrate and a first medicine residue; adding water 8 times the amount of the above Chinese medicinal materials into the first residue, decocting at 120 deg.C for 2 hr, filtering with 100 mesh sieve to obtain second filtrate, and mixing the two filtrates to obtain water extract;
(2) drying the water extract, pulverizing, sieving with 200 mesh sieve, and sterilizing the undersize product at 80 deg.C for 24 hr to obtain the Chinese medicinal preparation.
The clinical application condition of the traditional Chinese medicine preparation is as follows:
(1) case conditions: 193 female patients were collected and organized, with the oldest 70 years and the youngest 20 years.
(2) The treatment method adopts the traditional Chinese medicine preparation prepared in the embodiment 1-5 of the invention to be orally taken, 20g is taken each time, twice a day, and one month is a treatment course.
(3) The evaluation standard of curative effect is as follows:
and (3) curing: the symptoms and physical signs disappear or basically disappear, the pain and the discomfort completely disappear, the normal life is recovered, and the syndrome score is reduced by more than or equal to 95 percent;
the effect is shown: all or main symptoms are obviously eliminated, pain and discomfort obviously disappear, but slight symptoms also appear, most normal lives are recovered, and the syndrome integral is reduced by more than or equal to 70 percent;
the method has the following advantages: symptoms and physical signs are improved, pain and discomfort are relieved, but slight symptoms can appear, part of normal life is recovered, and the syndrome integral is reduced by more than or equal to 30%;
and (4) invalidation: symptoms and physical signs are not obviously improved or even aggravated, and the syndrome integral is reduced by less than 30%.
The disease efficacy score reduction degree is calculated by a nimodipine method, wherein the score reduction rate is (integration before treatment-integration after treatment) ÷ integration before treatment × 100%.
Clinical syndrome scoring table
Note: selecting the Chinese character check √ in a corresponding column according to the degree of symptoms.
And scoring according to the degree of the weight of the content in the table, wherein the integral is the sum of the scores in the table.
(4) The treatment results are as follows: the treatment results are shown in table 1:
| total number of cases | Cure of disease | Show effect | Is effective | Invalidation | High efficiency |
| 193 | 78 | 81 | 25 | 9 | 95.3％ |
(5) Typical clinical cases are:
I. yuan Zhi (a Chinese medicinal herb) is developed in 55 years and 2015 for mammary nodules in Yuan, the symptoms last for 5 years, the breast is conscious and distended and painful on both sides, the symptoms are aggravated when the emotion is poor, the breast can touch the striae and the nodules, the breast can be smoothly pushed, the breast is more green and sinew, the mouth is dry and bitter, the sexual emotion is acute, sublingual collaterals are purplish and tortuous, and the pulse is deep and astringent. After 5 courses of treatment, the breast distending pain is obviously relieved, the lump is obviously reduced, and the medicine is continuously taken for 1 course of treatment to consolidate the curative effect, and no recurrence occurs after 2 years of follow-up;
II. A certain Yang, a woman in 43 years old and beginning to suffer from mammary nodules in 2010, the symptoms last for 10 years, the breast is repeatedly distended or stabbed, the menstrual period is aggravated, the breast can touch the cord and the nodules without adhesion, the boundary is clear, the compression pain is aggravated, the menstrual period is purple-dark, blood clots exist, the amount is small, the tongue is light red, the fur is thin and yellow, and the pulse is wiry. After 4 treatment courses of the medicine, the breast distending pain is obviously relieved, the tumor is obviously reduced, the medicine is continuously taken for 1 treatment course to consolidate the curative effect, and no recurrence occurs in follow-up 2 years;
III, Zhao and Zhao, female, 37 years old and beginning to suffer from breast nodules in 2012, the symptoms last for 8 years, the unilateral breast can touch the cord and nodules to cause pain, the self feels repeated distending pain or dragging pain of the breast, the pain is aggravated before and after menstruation along with mood changes, dysphoria, dreaminess, insomnia, dry mouth, constipation, delayed menstruation, dark color, pale purple tongue, thin and white fur and smooth pulse. After 4 treatment courses of days, the pain and the discomfort of the breasts are obviously relieved, the cords and the nodules are obviously reduced and become small, the medicine is continuously taken for 1 treatment course to consolidate the curative effect, and no relapse occurs after 2 follow-up visits.
The clinical tests show that the plaster prepared in the preparation examples 1 to 5 of the invention has the effective rate of 95.3 percent for treating breast nodules, the significant efficiency of 82.4 percent and no recurrence phenomenon.
The preferred embodiments of the present invention have been described above in detail, but the present invention is not limited thereto. Within the scope of the technical idea of the invention, many simple modifications can be made to the technical solution of the invention, including combinations of various technical features in any other suitable way, and these simple modifications and combinations should also be regarded as the disclosure of the invention, and all fall within the scope of the invention.
Claims (10)
1. A traditional Chinese medicine composition for treating breast nodules is characterized by comprising the following components in parts by weight: taking 10 parts by weight of radix bupleuri as a reference, 2-25 parts by weight of radix curcumae, 6-30 parts by weight of safflower, 2-25 parts by weight of thunberg fritillary bulb, 2-25 parts by weight of curcuma zedoary, 2-25 parts by weight of cowherb seed, 4-30 parts by weight of angelica sinensis, 4-30 parts by weight of herba lycopi, 4-40 parts by weight of stiff silkworm, 2-25 parts by weight of solanum lyratum, 2-40 parts by weight of edible tulip, 4-40 parts by weight of selfheal, 2-15 parts by weight of spina gleditsiae, 2-25 parts by weight of dandelion, 2-40 parts by weight of oyster and 4-25 parts by weight of rhizoma cyperi.
2. The traditional Chinese medicine composition for treating breast nodules according to claim 1, wherein based on 10 parts by weight of said Chaihu, the content of radix Curcumae is 5-20 parts by weight, the content of safflower is 10-20 parts by weight, the content of Thunberg fritillary bulb is 5-20 parts by weight, the content of rhizoma Curcumae is 5-15 parts by weight, the content of cowherb seed is 5-20 parts by weight, the content of Chinese angelica is 5-20 parts by weight, the content of herba Lycopi is 5-20 parts by weight, the content of Bombyx Batryticatus is 10-30 parts by weight, the content of Solanum dulcamara is 5-20 parts by weight, the content of Pseudobulbus Cremastrae Seu pleiones is 5-30 parts by weight, the content of Spica Prunellae is 10-30 parts by weight, the content of spina Gleditsiae is 5-10 parts by weight, the content of herba Taraxaci is 5-20 parts by weight, the content of the oyster is 5-30 parts by weight, and the content of the rhizoma cyperi is 10-20 parts by weight.
3. A preparation method of a traditional Chinese medicine preparation for treating breast nodules is characterized by comprising the following steps:
(1) mixing bupleuri radix, radix Curcumae, Carthami flos, Bulbus Fritillariae Thunbergii, Curcumae rhizoma, semen Vaccariae, radix Angelicae sinensis, herba Lycopi, Bombyx Batryticatus, herba Solani Lyrati, Pseudobulbus Cremastrae seu pleiones, Prunellae Spica, spina Gleditsiae, herba Taraxaci, Concha Ostreae, and rhizoma Cyperi with water, decocting, and filtering to obtain water extract;
(2) processing the water extract to obtain the traditional Chinese medicine preparation;
wherein, based on 10 weight parts of the bupleurum falcatum, the content of the curcuma aromatica is 2-25 weight parts, the content of the safflower is 6-30 weight parts, the content of the thunberg fritillary bulb is 2-25 weight parts, the content of the curcuma zedoary is 2-25 weight parts, the content of the cowherb seed is 2-25 weight parts, the content of the angelica sinensis is 4-30 weight parts, the content of the eupatorium japonicum is 4-30 weight parts, the content of the stiff silkworm is 4-40 weight parts, the content of the solanum lyratum is 2-25 weight parts, the content of the edible tulip is 2-40 weight parts, the content of the selfheal is 4-40 weight parts, the content of the spina gleditsiae is 2-15 weight parts, the content of the dandelion is 2-25 weight parts, and the content of the oyster is 2-40 weight parts, the content of the rhizoma cyperi is 4 to 25 weight parts.
4. The preparation method of the traditional Chinese medicine preparation for treating breast nodules according to claim 3, wherein the content of radix Curcumae is 5-20 parts by weight, the content of safflower is 10-20 parts by weight, the content of thunberg fritillary bulb is 5-20 parts by weight, the content of zedoary is 5-15 parts by weight, the content of cowherb seed is 5-20 parts by weight, the content of angelica sinensis is 5-20 parts by weight, the content of herba Lycopi is 5-20 parts by weight, the content of stiff silkworm is 10-30 parts by weight, the content of solanum dulcamara is 5-20 parts by weight, the content of edible tulip is 5-30 parts by weight, the content of selfheal is 10-30 parts by weight, the content of spina gleditsiae is 5-10 parts by weight, the dandelion is 5-20 parts by weight, the oyster is 5-30 parts by weight, and the rhizoma cyperi is 10-20 parts by weight.
5. The preparation method of a Chinese medicinal preparation for treating breast nodules according to claim 3 or 4, wherein in step (1), the number of times of decoction is 2-4, and the filtrates obtained by filtration after each decoction are combined to obtain the water extract.
6. The method for preparing a Chinese medicinal preparation for treating breast nodules according to claim 5, wherein the weight ratio of the total weight of each Chinese medicinal raw material to water in each decoction process is 1:3-8, wherein the decocting conditions at least meet the following conditions: the decocting temperature is 100-.
7. The method for preparing a Chinese medicinal preparation for treating breast nodules according to claim 3 or 4, wherein in the step (2), the preparation treatment comprises: drying the water extract, pulverizing, sieving, and sterilizing the undersize product.
8. The method for preparing a Chinese medicinal preparation for treating breast nodules according to claim 7, wherein the sieving mesh is 150-200 mesh;
the conditions of disinfection and sterilization at least meet the following conditions: the temperature is 110-125 ℃, and the time is 20-90 min.
9. The Chinese medicinal preparation for treating breast nodules according to any one of claims 3 to 8.
10. A traditional Chinese medicine product for treating breast nodules, which is characterized by comprising the traditional Chinese medicine composition of claim 1 or 2 or a traditional Chinese medicine preparation prepared by the preparation method of any one of claims 3 to 8.
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