CN113604033B - Water-absorbing expansion polyurethane foam material for detecting esophageal cancer - Google Patents
Water-absorbing expansion polyurethane foam material for detecting esophageal cancer Download PDFInfo
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Abstract
The application relates to the field of high polymer materials, and particularly discloses a water-swelling polyurethane foam material for detecting esophageal cancer. The water-absorbing expansion polyurethane foam material for detecting the esophagus cancer comprises the following components in parts by weight: 20-50 parts of isocyanate, 20-60 parts of polyether, 4-12 parts of foaming agent, 1-5 parts of foam stabilizer, 2-8 parts of cell opening agent and 6-30 parts of water absorbent; the water absorption body comprises the following components in percentage by mass (6-10): (1-4) a water-absorbent resin and a lubricating body which are mixed, the lubricating body comprising paraffin or glycerin or polyethylene glycol. The water-absorbing expansion polyurethane foam material for detecting esophagus cancer can be used for improving the lubricity of polyurethane foam, and has the advantage of being difficult to cause secondary damage to the esophagus; in addition, the preparation method has the advantages of simple operation and wide application.
Description
Technical Field
The application relates to the field of high polymer materials, in particular to a water-absorbing expanded polyurethane foam material for detecting esophageal cancer.
Background
The main examination methods for esophageal cancer include the following: gastroscopy, upper gastrointestinal tract radiography, chest CT examination and esophageal cast-off cytology examination. Among them, the examination of esophageal exfoliation cytology is widely used because of its strong safety and less pain for patients. When the esophagus falling cytology examination is carried out, a detector swallows the plastic double-cavity tube or single-cavity tube of the wired net air bag, when the air bag enters the esophagus, air is injected into the air bag to expand and cling to the esophagus wall, and then the air bag is pulled out slightly to enable the fine net on the surface of the air bag to rub against pathological changes. When the air sac reaches the upper mouth of the esophagus, the air in the air sac is sucked out completely, then the air sac is taken out from the oral cavity, and the cytological examination is carried out by smearing, fixing and dyeing at once.
However, when the air bag is used for detection, the air bag needs to be inflated firstly and then exhausted, and the operation is complex. The polyurethane foam has a latticed or film-shaped porous structure inside, has a very large specific surface area, and contains abundant capillary channels inside. Therefore, when the polyurethane foam is contacted with water, the polyurethane foam can absorb the water on the surface of the polyurethane foam, and the water is absorbed and filled in capillary channels to expand the polyurethane foam. Due to this property, polyurethane foam is applicable in esophageal cancer detection. During detection, a detector swallows wired polyurethane foam, after the polyurethane foam enters an esophagus, the detector drinks water to enable the polyurethane foam to absorb water and expand, so that the polyurethane foam is tightly attached to the esophagus wall, then the polyurethane foam is pulled out through the line gently, in the process, the surface of the polyurethane foam and the esophagus wall rub to scrape cells on the esophagus wall, finally the polyurethane foam is taken out from the oral cavity, and smearing, fixing and dyeing are immediately performed for cell detection.
In view of the above-mentioned related art, the inventors believe that the polyurethane foam has poor lubricity and have a problem that the friction force between the polyurethane foam and the esophageal wall during the pulling-out process is too large, thereby easily causing secondary damage to the esophagus by the polyurethane foam.
Disclosure of Invention
In order to improve the lubricity of polyurethane foam and enable the polyurethane foam not to cause secondary damage to an esophagus easily, the application provides a water-absorbing expansion polyurethane foam material for detecting esophagus cancer.
The application provides a water-swelling polyurethane foam material for detecting esophageal cancer, which adopts the following technical scheme:
a water-absorbing expansion polyurethane foam material for detecting esophagus cancer comprises the following components in parts by weight: 20-50 parts of isocyanate, 20-60 parts of polyether, 4-12 parts of foaming agent, 1-5 parts of foam stabilizer, 2-8 parts of cell opening agent and 6-30 parts of water absorbent; the water absorption body comprises the following components in percentage by mass (6-10): (1-4) a water-absorbent resin and a lubricating body comprising paraffin or glycerin or polyethylene glycol in a mixture.
By adopting the technical scheme, the pore-forming agent is used for realizing pore-forming of the polyurethane foam, and the softness of the polyurethane foam is improved. The water-absorbing body is used for realizing water absorption and expansion of the polyurethane foam. Because the lubricating body with a proper amount is added into the water-absorbing expanded polyurethane foam material for detecting the esophageal cancer, the lubricating body is wetted by water after a detector swallows the polyurethane foam material into an esophagus to absorb water, thereby playing a role in lubricating. On the premise of not influencing the cell scraping of the polyurethane foam on the esophageal wall, the lubricating property of the polyurethane foam is improved, so that the polyurethane foam is not easy to cause secondary damage to the esophagus. Meanwhile, when the polyurethane foam is pulled out from the esophagus, the lubricating body flows and covers the cells scraped from the surface of the polyurethane foam during lubrication, so that the scraped cells are not easy to fall from the surface of the polyurethane foam.
Preferably, the lubricating body is formed into a water-swelling microcapsule material structure, and a core material of the water-swelling microcapsule material comprises polyethylene glycol 4000.
By adopting the technical scheme, the wall material of the water-absorbing swelling microcapsule material can protect the core material, so that the core material is not easy to damage and lose efficacy. When the polyurethane foam prepared by the lubricating body absorbs water, the wall material of the water-absorbing swelling microcapsule material absorbs water and swells, so that the polyethylene glycol 4000 is released. The polyethylene glycol 4000 fixes water molecules through hydrogen bonds, and the water molecules expand to form colloid after absorbing water in the esophagus. The colloid can lubricate the esophagus on one hand, and can enlarge the volume of the polyurethane foam on the other hand, and the colloid and the water-absorbing body have a synergistic effect, so that the water-absorbing expansion rate of the polyurethane foam is improved. The tester swallows the small polyurethane foam to realize the high-rate expansion of the polyurethane foam, so that the difficulty of swallowing the polyurethane foam by the tester is reduced. Polyethylene glycol 4000 absorbs water and expands and makes the volume grow of polyurethane foam, can also improve polyurethane foam's softness degree simultaneously to it is softer when making polyurethane foam surface and esophagus wall contact, further is difficult for causing secondary damage to the esophagus.
Preferably, the water-absorbing swelling microcapsule material is a water-absorbing swelling microcapsule material subjected to surface modification, and the specific surface modification steps are as follows: mixing and stirring the water-absorbing swelling microcapsule material and a silane coupling agent to obtain the surface modified water-absorbing swelling microcapsule material.
By adopting the technical scheme, the surface modified water-absorbing swelling microcapsule material can improve the mixing uniformity of the lubricating body and the rest components of the polyurethane foam, so that the lubricating body and the rest components of the polyurethane foam form good combination, thereby being convenient for forming uniform and stable polyurethane foam material and further improving the lubricating property of the polyurethane foam after water absorption.
Preferably, the wall material of the water-swellable microcapsule material comprises one or more of starch and gelatin.
By adopting the technical scheme, the starch and the gelatin are simple and easy to obtain and have low price. The starch is melted after absorbing water, so that the wall material of the water-absorbing swelling microcapsule material is broken to release the lubricating material for esophagus lubrication. The gelatin is a lubricating material which is expanded after water is absorbed, so that the wall material of the water-absorbing swelling microcapsule material is burst to release the lubricating material.
Preferably, the wall material of the water-swelling microcapsule material comprises starch and gelatin in a mass ratio of (6-10) to (1-5).
By adopting the technical scheme, the water-absorbing swelling type microcapsule wall material comprises starch and gelatin, and the lubricating material can be released through two ways of the starch and the gelatin, so that the reliability of the lubricating material released from the water-absorbing swelling type microcapsule wall material is improved. Meanwhile, the gelatin has good fluidity, so that the gelatin carries the lubricating material to be dispersed in the raw material of the polyurethane foam, the dispersibility of the lubricating material in the polyurethane foam is improved, the lubricating material and the rest components of the polyurethane foam form good combination, and the lubricity of the polyurethane foam is further improved. In addition, the gelatin swells after absorbing water, and the expansion rate of the polyurethane foam can be further improved.
Preferably, the preparation method of the lubricating body comprises the following steps:
(1) Preparing a swelling solution: mixing the wall material of the water-absorbing swelling microcapsule material with water, heating and stirring at 100-140 ℃, and cooling to 40-50 ℃ to obtain a swelling solution;
(2) Preparing intermediate liquid: mixing the core material of the water-absorbing swelling microcapsule material with the swelling solution prepared in the step (1) at 40-50 ℃, stirring and adjusting the pH value to 4-6 to obtain an intermediate solution;
(3) Preparing microsphere liquid: controlling the temperature of the intermediate liquid prepared in the step (2) to be 30-36 ℃, stirring for 30-40min, then cooling to 2-10 ℃, and adding a sulfuric acid solution with the mass fraction of 20-50% into the intermediate liquid prepared in the step (2) while stirring in the cooling process to obtain a microsphere liquid;
(4) And (3) curing: and (4) adding 30-40% by mass of formaldehyde solution into the microsphere solution prepared in the step (3), curing, filtering and washing to obtain a lubricating body.
By adopting the technical scheme, the gelatin is melted into fluid at higher temperature in the step (1), and the fluid and the starch are dispersed in water together to form the swelling solution. And (3) gradually cooling, regulating the pH value, adding a sulfuric acid solution to prepare a microsphere solution, and coating the gelatin and the starch outside the lubricating material. And (4) coating the gelatin and the starch outside the lubricating material for solidification, and washing to obtain the lubricating body.
Preferably, the stirring speed in the step (1) is 130-150r/min, the stirring speed in the step (2) is 230-240r/min, and the stirring speed in the step (3) is 320-350r/min.
By adopting the technical scheme, the stirring speed in the three steps is gradually increased, which is beneficial to forming the lubricating body with smaller particle size, so that the lubricating body is conveniently dispersed in the rest components of the polyurethane foam, and the bonding performance of the lubricating body and the rest components of the polyurethane foam is further improved, thereby further improving the lubricating property of the polyurethane foam.
Preferably, the volume swelling ratio of the wall material of the water-absorbing swelling microcapsule material is 1-5%.
By adopting the technical scheme, the release of the core material of the water-absorbing swelling microcapsule material is facilitated, and the esophagus is lubricated conveniently.
In summary, the present application has the following beneficial effects:
1. because this application has adopted proper amount of lubricating material to add to esophagus cancer to detect with the inflation polyurethane foam material that absorbs water, consequently after the person of detection swallows above-mentioned polyurethane foam to the esophagus in the water absorption, lubricating material is moistened by water, play the lubrication action, do not influence under the prerequisite that polyurethane foam scraped down the cell on the esophagus wall, polyurethane foam's lubricity has been improved, make polyurethane foam be difficult for causing secondary damage to the esophagus, and simultaneously, polyurethane foam when pulling out in the esophagus, lubricating material flows and covers on polyurethane foam surface scrapes down the cell when lubricating, make the cell of scraping down be difficult for dropping from polyurethane foam surface.
2. The fixed hydrone of polyethylene glycol 4000's hydrogen bond expands after absorbing moisture in the esophagus and forms the colloid, and this colloid can lubricate the esophagus on the one hand, and on the other hand can make polyurethane foam's volume grow, with the body synergism that absorbs water, improves polyurethane foam's the water expansion rate that absorbs water, and the inflation of polyurethane foam high magnification can be realized to the less polyurethane foam of detection person swallowing to the degree of difficulty that the detection person swallowed polyurethane foam has been reduced.
3. The water-absorbing swelling type microcapsule wall material contains starch and gelatin, the lubricating material can be released through two ways of the starch and the gelatin, the reliability of the lubricating material released from the water-absorbing swelling type microcapsule wall material is improved, and meanwhile, the gelatin has good fluidity so as to carry the lubricating material to be dispersed in the raw material of the polyurethane foam, improve the dispersibility of the lubricating material in the polyurethane foam, enable the lubricating material to be well combined with other components of the polyurethane foam, and further improve the lubricating property of the polyurethane foam.
Detailed Description
The present application will be described in further detail with reference to examples.
In the examples of the present application, the equipment used is shown in Table 1:
table 1 instrument device of the present embodiment
In the examples of the present application, the drugs used are shown in Table 2:
table 2 pharmaceutical products according to embodiments of the present application
Preparation example of Water-absorbent Material
Preparation example 1: the water-absorbing body is prepared by the following method:
(1) Preparing a swelling solution: weighing 6kg of starch and 1kg of gelatin, and mixing to obtain a wall material of the water-absorbing swelling microcapsule material; weighing 5kg of wall material of the water-absorbing swelling microcapsule material, mixing the wall material with 20kg of water, heating at 100 ℃, stirring for 10min at the rotating speed of 130r/min by a stirrer, and cooling to 40 ℃ to obtain swelling liquid;
(2) Preparing intermediate liquid: weighing 5kg of polyethylene glycol 4000, and mixing with the swelling solution obtained in the step (1) to obtain a mixture; controlling the temperature of the mixture at 40 ℃, stirring the mixture through a stirrer at a stirring speed of 230r/min for 20min, dropwise adding acetic acid with the mass fraction of 10% into the mixture during stirring, and adjusting the pH value of the compound to 4 to obtain an intermediate solution;
(3) Preparing microsphere solution: controlling the temperature of the intermediate liquid in the step (2) to be 30 ℃, increasing the stirring speed of a stirrer, stirring the intermediate liquid at the rotating speed of 320r/min for 30-40min, cooling the intermediate liquid to 2 ℃, and adding 2kg of sulfuric acid solution with the mass fraction of 20% into the intermediate liquid while stirring at the rotating speed of 320r/min in the cooling treatment process to obtain microsphere liquid;
(4) And (3) curing: adding 2kg of 30% formaldehyde solution into the microsphere solution prepared in the step (3), curing, filtering, and washing with water for 3 times to obtain a lubricating body;
(5) Surface modification: and (5) adding 5kg of silane coupling agent into the lubricating body obtained in the step (4), and stirring at the rotating speed of 120r/min for 5min to obtain a modified lubricating body.
(6) Mixing: 10kg of modified lubricating body is mixed with 20kg of water-absorbent resin, and the mixture is stirred for 2min at the rotating speed of 120r/min to obtain the water-absorbent body.
Preparation examples 2 to 3
The water-absorbent bodies of production examples 2 to 3 were different from those of production example 1 in the component ratio in each step, and are specifically shown in Table 3.
TABLE 3 component proportions in preparation examples 1 to 3
Preparation example 4: the water absorbent is prepared by the following method:
(1) Preparing a swelling solution: weighing 6kg of starch and 1kg of gelatin, and mixing to obtain a wall material of the water-absorbing swelling microcapsule material; weighing 5kg of wall material of the water-absorbing swelling microcapsule material, mixing the wall material with 20kg of water, heating at 120 ℃, stirring for 15min at a rotating speed of 140r/min by a stirrer, and cooling to 45 ℃ to obtain a swelling solution;
(2) Preparing intermediate liquid: weighing 5kg of polyethylene glycol 4000, and mixing with the swelling solution obtained in the step (1) to obtain a mixture; controlling the temperature of the mixture at 45 ℃, stirring the mixture through a stirrer at a stirring speed of 235r/min for 25min, dropwise adding acetic acid with the mass fraction of 10% into the mixture in the stirring process, and adjusting the pH value of the compound to 4 to obtain an intermediate solution;
(3) Preparing microsphere liquid: controlling the temperature of the intermediate solution in the step (2) to be 34 ℃, increasing the stirring speed of a stirrer, stirring the intermediate solution at the rotating speed of 335r/min for 35min, cooling the intermediate solution to 6 ℃, and adding 2kg of sulfuric acid solution with the mass fraction of 50% into the intermediate solution while stirring at the rotating speed of 335r/min in the cooling treatment process to obtain microsphere solution;
(4) And (3) curing: and (4) adding 2kg of 35% formaldehyde solution into the microsphere solution prepared in the step (3), curing, filtering, and washing with water for 4 times to obtain a lubricating body.
(5) Surface modification: and (4) adding 5kg of silane coupling agent into the lubricating body obtained in the step (4), and stirring for 6min at the rotating speed of 130r/min to obtain the modified lubricating body.
(6) Mixing: 10kg of modified lubricating body is mixed with 20kg of water-absorbent resin, and the mixture is stirred for 2min at the rotating speed of 120r/min to obtain the water-absorbent body.
Preparation example 5: the water absorbent is prepared by the following method:
(1) Preparing a swelling solution: weighing 6kg of starch and 1kg of gelatin, and mixing to obtain a wall material of the water-absorbing swelling microcapsule material; weighing 5kg of wall material of the water-absorbing swelling microcapsule material, mixing the wall material with 20kg of water, heating at 140 ℃, stirring for 20min at a rotating speed of 150r/min by a stirrer, and cooling to 50 ℃ to obtain swelling liquid;
(2) Preparing intermediate liquid: weighing 15kg of polyethylene glycol 4000, and mixing with the swelling solution obtained in the step (1) to obtain a mixture; controlling the temperature of the mixture at 50 ℃, stirring the mixture through a stirrer at a stirring speed of 240r/min for 30min, dropwise adding acetic acid with the mass fraction of 10% into the mixture during stirring, and adjusting the pH value of the compound to 6 to obtain an intermediate solution;
(3) Preparing microsphere liquid: controlling the temperature of the intermediate liquid in the step (2) to be 36 ℃, increasing the stirring speed of a stirrer, stirring the intermediate liquid at the rotating speed of 350r/min for 40min, cooling the intermediate liquid to 10 ℃, and adding 2kg of sulfuric acid solution with the mass fraction of 80% into the intermediate liquid while stirring at the rotating speed of 350r/min in the cooling treatment process to obtain microsphere liquid;
(4) And (3) curing: and (4) adding 2kg of 40% formaldehyde solution into the microsphere solution prepared in the step (3), curing, filtering, and washing with water for 5 times to obtain a lubricating body.
(5) Surface modification: and (4) adding 5kg of silane coupling agent into the lubricating body obtained in the step (4), and stirring for 7min at the rotating speed of 140r/min to obtain the modified lubricating body.
(6) Mixing: 10kg of modified lubricating body is mixed with 20kg of water-absorbent resin, and the mixture is stirred for 2min at the rotating speed of 120r/min to obtain the water-absorbent body.
Preparation examples 6 to 7
The water-absorbent bodies of production examples 6 to 7 were different from those of production example 1 in the stirring speed in each step, and are specifically shown in Table 4.
TABLE 4 stirring speed in Each step of preparation example 1 and preparation examples 6 to 7
Preparation example 8: the difference between the preparation example and the preparation example 1 is that:
the wall material of the water-absorbing swelling microcapsule material in the step (1) only contains starch.
Preparation example 9: the difference between the preparation example and the preparation example 1 is that:
glycerin was used in place of polyethylene glycol 4000 in step (2).
Preparation example 10: the difference between the preparation example and the preparation example 1 is that:
paraffin wax is used to replace polyethylene glycol 4000 in step (2).
Preparation example 11: the difference between the preparation example and the preparation example 1 is that:
the lubricant of the present preparation example was not subjected to surface modification in step (5).
Preparation example 12: 10kg of polyethylene glycol 4000 as a lubricant was mixed with 20kg of water-absorbent resin, and stirred at a rotation speed of 120r/min for 2min to obtain a water-absorbent body.
Preparation example 13: 10kg of polyethylene glycol 600 as a lubricant was mixed with 20kg of water-absorbent resin, and stirred at a rotation speed of 120r/min for 2min to obtain a water-absorbent body.
Examples
Example 1
S1, weighing 20kg of polyether, 20kg of isocyanate, 4kg of foaming agent, 1kg of foam stabilizer, 2kg of cell opening agent and 6kg of water absorbent in preparation example 1 for later use.
S2, putting the foaming agent, the foam stabilizer, the cell opening agent, the super absorbent resin and the lubricating body into a stirrer, and stirring for 20min at the rotating speed of 100r/min to obtain an auxiliary agent mixture;
s3, adding the auxiliary agent mixture into the polyether and the isocyanate, stirring, mixing and stirring for 5min at the rotating speed of 100r/min to obtain a total mixture, quickly injecting the total mixture into a mold, and allowing the total mixture to foam freely until the foam height is not increased any more to obtain a foam body;
s7, taking the foam out of the mold, removing the surface skin of the foam, curing for 1min at room temperature, and cutting to obtain the water-absorbing expanded polyurethane foam material for detecting the esophageal cancer.
Examples 2 to 3
The water-swellable polyurethane foam for esophageal cancer detection in examples 2 to 3 was different from that in example 1 in the component ratio, as shown in Table 5.
TABLE 5 component ratios in examples 1-3
Examples 4 to 13
The water-absorbent expanded polyurethane foam for esophageal cancer detection in examples 4 to 13 is different from that in example 1 in the selection of the water-absorbent material, and is specifically shown in table 6.
TABLE 6 Water-absorbent bodies of examples 4 to 13
Comparative example
Comparative example 1: this comparative example differs from example 1 in that:
the water-absorbent body of this comparative example contained only the water-absorbent resin and contained no lubricant.
Performance test
1. Lubricating performance
(1) Taking lubricating liquid: 10g of the water-absorbing expanded polyurethane foam for detecting esophageal cancer, which is prepared by the method, is taken out, and the polyurethane foam is put into a 1000ml beaker containing 600ml of water to be expanded after absorbing water. And taking out the polyurethane foam after water absorption and expansion after 2min, wearing the disposable rubber gloves to extrude the liquid in the polyurethane foam after water absorption and expansion, and carrying the liquid by using a beaker to obtain a plurality of different lubricating liquids for later use.
(2) Preparing an oil product: adding 60g of base oil into a beaker, then adding 6g of the multiple parts of lubricating liquid in the step (1) into the beaker, and stirring the mixture at the rotating speed of 120r/min for 40min to obtain multiple parts of oil product.
(3) And (3) measurement: different oil products are selected to carry out friction experiments on a four-ball friction tester, four balls are closely attached and reset under the room temperature condition, the top ball rotates in a spinning mode, and the lower three bottom balls are fixed and do not rotate. The rotating speed is 1000r/min, the experimental load is 392N, the experimental time is 30min each time, and the average wear-scar diameter of the bottom ball is measured by using an electron microscope after the experiment is finished.
Water absorption of
A block material of 100 mm. Times.100 mm. Times.50 mm was immersed in tap water for 30min, and the mass thereof was weighed to calculate the water absorption capacity A (ratio of the mass of absorbed water to the mass of foam). A = (m) 1 -m 0 )/m 0 In the formula m 1 、m 0 The mass (kg) of the sample after water absorption and the mass (kg) of the sample before water absorption were measured, respectively.
Water absorption expansion ratio
The change in length of the sample of the above size before and after water absorption was measured to calculate the water absorption linear expansion coefficient P. P = (L) 3 -L 2 )×100%/L 2 In the formula L 3 、L 2 The lengths of the samples after and before water absorption, respectively, at the time of drying.
TABLE 7 Performance test Table
Comparing examples 1-3, the lubricating performance of example 2 is best, since the wear scar diameter of example 2 is smallest, and the water absorption rate and water expansion rate of example 2 are largest, indicating that this example is feasible.
Examples 4 and 5 were compared with example 1, and example 1 used the modified lubricant of production example 1, example 4 used the modified lubricant of production example 2, and example 5 used the modified lubricant of production example 3. The production examples 1 to 3 were different in the component ratio in producing the modified lubricant. Since the wear-mark diameter of example 4 was the smallest, the lubricating performance of example 4 was the best, and it is explained that the component ratio was the best when the modified lubricating body was prepared in example 4.
Examples 6 and 7 were compared with example 1, and example 1 used the modified lubricant of production example 1, example 6 used the modified lubricant of production example 4, and example 7 used the modified lubricant of production example 5. The production examples 1 and 4 to 5 were different in the process conditions of the respective steps for producing the modified lubricating bodies. While the wear scar diameter is the smallest for example 6, the lubrication performance is best for example 6, illustrating the best process conditions for each step in preparing the modified lubricant in example 6.
Examples 8 and 9 were compared with example 1, and example 1 used the modified lubricant of production example 1, example 8 used the modified lubricant of production example 6, and example 9 used the modified lubricant of production example 7. Preparation example 1 and preparation examples 6 to 7 were different in the stirring speed in each step when preparing the modified lubricating bodies. While the wear scar diameter of example 8 was the smallest, and therefore the lubricating properties of example 8 were the best, indicating that the modified lubricating body of example 8 was prepared with the best stirring speed in each step when preparing the modified lubricating body, and the modified lubricating body having the smallest particle size was prepared, and the bonding properties of the lubricating body with the remaining components of the polyurethane foam were improved.
Example 10 was compared with example 1, example 1 used the modified lubricant of preparation example 1, and the wall material of the water-swellable microcapsule material in preparation step (1) of the modified lubricant of preparation example 1 comprised starch and gelatin. Example 10 using the modified lubricant of production example 8, the wall material of the water-absorbent swelling microcapsule material in production step (1) of the modified lubricant of production example 8 contained only starch. The wear-leveling diameter of the embodiment 1 is smaller, so the lubricating performance of the embodiment 1 is better; meanwhile, the water absorption rate and the water swelling rate of example 1 are relatively high, which indicates that the gelatin component in example 1 improves the lubricity and the water swelling rate of the polyurethane foam for esophageal cancer detection.
Example 11 is compared to example 1, with example 11 differing from example 1 in that example 11 employs glycerol instead of polyethylene glycol 4000 in example 1. The wear scar diameter of example 1 is smaller, so the lubricating performance of example 1 is better, which shows that the polyethylene glycol 4000 in example 1 improves the lubricating performance of the polyurethane foam for detecting esophageal cancer.
Example 12 is compared to example 1 and example 11 differs from example 1 in that example 11 employs paraffin wax instead of polyethylene glycol 4000 in example 1. The wear-leveling diameter of example 1 is small, so that the lubricating performance of example 1 is good, which shows that the polyethylene glycol 4000 in example 1 improves the lubricating performance of the polyurethane foam for detecting esophageal cancer.
Example 13 was compared with example 1, and example 13 differs from example 1 in that the lubricant in example 13 was not surface-modified. Since the wear-scar diameter in example 1 is small, the lubricating performance in example 1 is good, and it is explained that the modification of the lubricant in example 1 improves the dispersibility of the lubricant in the water-absorbent expanded polyurethane foam for esophageal cancer detection.
Example 14 was compared with example 1, and example 14 was different from example 1 in that example 14 was directly added to the water-swellable polyurethane foam for esophageal cancer detection using polyethylene glycol 4000 as a lubricant. The lubricating performance of example 1 is better because the wear-scar diameter of example 1 is smaller, which indicates that the microcapsule structure of the lubricant in example 1 protects the polyethylene glycol 4000, so that the polyethylene glycol 4000 is not easily damaged and fails.
Example 15 was compared with example 14, and example 14 was different from example 15 in that example 14 used polyethylene glycol 4000 as a lubricant and added to the water-absorbent expanded polyurethane foam for esophageal cancer detection, and example 15 used polyethylene glycol 600 as a lubricant and added to the water-absorbent expanded polyurethane foam for esophageal cancer detection. On the other hand, the wear-leveling diameter of example 14 is small, so that the lubricating property of example 14 is good, and the water-swelling rate of example 14 is large, which shows that the polyethylene glycol 4000 in example 11 can improve the lubricating property and the water-swelling rate of the water-swelling polyurethane foam for esophageal cancer detection.
Finally, comparative example 1 was compared with example 1, and comparative example 1 was different from example 1 in that no lubricant was added to the components of the water-swellable polyurethane foam for esophageal cancer detection of comparative example 1. The smaller diameter of the wear scar in example 1 indicates that the lubricating property of example 1 is better, and the lubricating body in example 1 improves the lubricating property of the water-absorbing expanded polyurethane foam material for detecting esophageal cancer.
The specific embodiments are only for explaining the present application and are not limiting to the present application, and those skilled in the art can make modifications to the embodiments without inventive contribution as required after reading the present specification, but all the embodiments are protected by patent law within the scope of the claims of the present application.
Claims (3)
1. A water-absorbing expansion polyurethane foam material for detecting esophagus cancer is characterized in that: comprises the following components in parts by weight:
20-50 parts of isocyanate;
20-60 parts of polyether;
4-12 parts of a foaming agent;
1-5 parts of a foam stabilizer;
2-8 parts of a pore forming agent;
6-30 parts of a water absorbent;
the water absorption body comprises the following components in percentage by mass 6-10:1-4 a water absorbent resin and a lubricant, mixed;
the lubricating body is a water-absorbing swelling microcapsule material, and a core material of the water-absorbing swelling microcapsule material comprises polyethylene glycol 4000;
the water-absorbing swelling microcapsule material is a water-absorbing swelling microcapsule material subjected to surface modification, and the specific surface modification steps are as follows: mixing and stirring the water-absorbing swelling microcapsule material and a silane coupling agent to obtain a surface-modified water-absorbing swelling microcapsule material;
the wall material of the water-absorbing swelling microcapsule material comprises starch and gelatin in a mass ratio of 6-10;
the preparation method of the lubricating body comprises the following steps:
(1) Preparing a swelling solution: mixing the wall material of the water-absorbing swelling microcapsule material with water, heating and stirring at 100-140 ℃, and cooling to 40-50 ℃ to obtain a swelling solution;
(2) Preparing intermediate liquid: mixing the core material of the water-absorbing swelling microcapsule material with the swelling solution prepared in the step (1) at 40-50 ℃, stirring and adjusting the pH value to 4-6 to obtain an intermediate solution;
(3) Preparing microsphere liquid: controlling the temperature of the intermediate liquid prepared in the step (2) to be 30-36 ℃, stirring for 30-40min, then cooling to 2-10 ℃, and adding a sulfuric acid solution with the mass fraction of 20-50% into the intermediate liquid prepared in the step (2) while stirring in the cooling process to obtain a microsphere liquid;
(4) And (3) curing: adding 30-40% by mass of formaldehyde solution into the microsphere solution prepared in the step (3), solidifying, filtering and washing to obtain a lubricating body;
(5) Surface modification: adding a silane coupling agent into the lubricating body, and mixing and stirring for 5min at the rotating speed of 120r/min to obtain the modified lubricating body.
2. The water-swellable polyurethane foam for esophageal cancer detection according to claim 1, wherein: the stirring speed in the step (1) is 130-150r/min, the stirring speed in the step (2) is 230-240r/min, and the stirring speed in the step (3) is 320-350r/min.
3. The water-swellable polyurethane foam for esophageal cancer detection according to claim 1, wherein: the volume swelling ratio of the wall material of the water-absorbing swelling microcapsule material is 1-5%.
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| CN103436007A (en) * | 2013-09-06 | 2013-12-11 | 泉州源利鞋材有限公司 | Water-absorbing soft polyurethane foam and preparation method thereof |
| CN113736058A (en) * | 2021-09-27 | 2021-12-03 | 航天特种材料及工艺技术研究所 | Water-absorbing foam material and preparation method thereof |
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| CN103436007A (en) * | 2013-09-06 | 2013-12-11 | 泉州源利鞋材有限公司 | Water-absorbing soft polyurethane foam and preparation method thereof |
| CN113736058A (en) * | 2021-09-27 | 2021-12-03 | 航天特种材料及工艺技术研究所 | Water-absorbing foam material and preparation method thereof |
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