CN113599307B

CN113599307B - Fullerene compositions for hair care

Info

Publication number: CN113599307B
Application number: CN202110940612.9A
Authority: CN
Inventors: 李慧; 王春儒; 许哲; 孙泽川
Original assignee: Beijing Fullcan Biotechnology Co ltd; Institute of Chemistry CAS
Current assignee: Beijing Fullcan Biotechnology Co ltd; Institute of Chemistry CAS
Priority date: 2021-08-17
Filing date: 2021-08-17
Publication date: 2023-09-22
Anticipated expiration: 2041-08-17
Also published as: CN113599307A

Abstract

The present disclosure relates to a fullerene composition characterized in that the composition comprises: fullerenes, isododecane, hydrogenated polyisobutene and tocopheryl acetate, and their use in the preparation of personal care products. The hair care product prepared from the fullerene composition can remarkably improve scalp environment, and the number of blackening people at the root of white hair after 30 days of use is remarkably increased, and the growth of the medulla of white hair can be remarkably promoted.

Description

Fullerene compositions for hair care

Technical Field

The present disclosure relates to the chemical arts, particularly to the daily chemical arts, and more particularly to a fullerene composition having hair care effect.

Background

Scientist Kroto, smalley, curl et al in 1985 found C60 fullerenes when studying carbon elements deep in space, and three in 1996 were thus awarded Nobel chemistry. Fullerene, diamond and graphite are allotropes of carbon. C60 is a spherical molecule consisting of 60 carbon atoms, consisting of 12 pentagons and 20 hexagons, each carbon atom and the adjacent three carbon atoms being hybridized by SP2 to form a bond, known as a football alkene, because of the shape of a football.

The large pi bond conjugated system formed by a plurality of P orbits of the fullerene has stronger electron accepting capability, and has excellent free radical scavenging performance, which is called as 'free radical sponge', and also has excellent oxidation resistance due to the unique structure and physical and chemical properties. So that the composition has been widely paid attention to cosmetic materials, biological medicines and the like.

By embedding C60 in surfactants, C60 can still eliminate intracellular active oxygen, inhibit mitochondrial depolarization, activation of cysteine proteases, exposure of phosphatidylserine on cell membranes, and division of DNA, C60 shows the effect of protecting cells from oxidative apoptosis. The C60 liposome complex plays a role in antioxidation by defending UVA from damaging skin structures, cell nuclei and collagen fibers and penetrating human skin tissues, is hundreds times of that of vitamin C, and can quench free radicals.

As external products, there have been reported fullerene-related products such as C60-PVP (patent application Nos. 200480005008.1 and 200580049615.2), in which the content of C60 is not more than 1% due to the preparation process and the limitation of the compounding characteristics of PVP and C60. As another example, patent 201810871219.7, the product of which cannot be directly formulated into essential oil products due to the use of a water-soluble polymer composition. The raw materials used in the patent ZL201811299206.3 are mostly vegetable oil compounded fullerene, and the vegetable oil is directly applied to the hair part to further increase the burden of hair follicles, so that the scalp hair follicles are excessively greasy and blocked.

Fullerenes are nonpolar molecules with strong hydrophobicity and can only be dissolved in nonpolar organic solvents such as toluene, benzene, cyclohexane, chloroform, which are harmful to living organisms. The prior art has a plurality of defects, including complex process, high industrialization cost, no mass production and difficult industrialization; the use of large amounts of organic reagents results in solvent residues; the fullerene and the polymer material or the composition are compounded to influence the later use effect, and are difficult to be absorbed by skin. Therefore, in order to better promote absorption, fullerene is compounded with volatile and absorption-promoting grease, and the compound is easy to be quickly absorbed by scalp in a molecular state, so that the product can be more easily acted on hair follicles, and the effects of better scavenging free radicals, repairing hair follicles, promoting black growth or promoting white hair to turn black so as to inhibit white hair generation are urgently needed to be solved.

Disclosure of Invention

To overcome the above-described drawbacks of the prior art, the present disclosure provides a fullerene composition for hair care, which has effects of promoting black growth, promoting white hair blackening, inhibiting white hair generation, relieving scalp sensitivity, reducing scalp red blood wire generation, reducing scalp itching, reducing hair follicle grease secretion, removing dandruff, increasing hair luster, and thickening hair, including one or more of fullerene, isododecane, hydrogenated polyisobutene, polymethylsiloxane, and cyclopentamethicone, when used for hair care, as a personal care product composition, cosmetic composition, or pharmaceutical composition for hair care.

Specifically, the present disclosure provides a fullerene composition, characterized in that the composition comprises: fullerenes, isododecane, hydrogenated polyisobutene and tocopheryl acetate.

Preferably, the composition further comprises one or more of caprylic capric triglyceride, polymethylsiloxane, cyclopentamethicone, vitamin E, diethyl hexyl maleate, coco caprylate/caprate, bisabolol, ginger oil.

Preferably, the composition comprises fullerenes, isododecane, hydrogenated polyisobutene, caprylic capric triglyceride, diethyl hexyl maleate, coco caprylate/caprate, tocopheryl acetate.

Preferably, the composition comprises fullerenes, isododecane, hydrogenated polyisobutene, caprylic capric triglyceride, diethyl hexyl maleate, cocoyl caprylate/caprate, tocopheryl acetate, bisabolol and ginger oil.

Preferably, the mass ratio of fullerene, isododecane, hydrogenated polyisobutene and tocopheryl acetate in the composition is (0.01-10): (5-60): (0.01-5): (0.1-20), preferably (0.01-10): (10-50): (0.05-4): (1-15), more preferably (0.05-3): (20-40): (0.05-2): (1-10).

Preferably, the mass ratio of fullerene, isododecane, hydrogenated polyisobutene, caprylic capric triglyceride, diethyl hexyl maleate, coco caprylic/capric ester and tocopheryl acetate in the composition is (0.01-10): (5-60): (0.01-5): (0.5-10): (1-40): (1-40): (0.1-20), preferably (0.01-10): (10-50): (0.05-4): (1-8): (2-30): (2-30): (1-15), more preferably (0.05-3): (20-40): (0.05-2): (1-5): (5-20): (5-20): (1-10).

Preferably, the mass ratio of fullerene, isododecane, hydrogenated polyisobutene, caprylic capric triglyceride, diethyl hexyl maleate, cocoyl caprylate/caprate, and tocopheryl acetate, bisabolol and ginger oil in the composition is (0.01-10): (5-60): (0.01-5): (0.5-10): (1-40): (1-40): (0.1-20): (0.01-2): (0.01-2), preferably (0.01-10): (10-50): (0.05-4): (1-8): (2-30): (2-30): (1-15): (0.05-1.5): (0.05-1.5), more preferably (0.05-3): (20-40): (0.05-2): (1-5): (5-20): (5-20): (1-10): (0.05-1): (0.05-1).

The fullerene composition of the present disclosure may further include a penetration enhancer.

Preferably, the penetration enhancer is one or more of menthol, azone and borneol.

Preferably, the penetration enhancer is menthol.

Preferably, the mass ratio of menthol to fullerene is (0.01-10): (0.01-10), preferably (0.05-8): (0.01-10), more preferably (1-5): (0.05-3).

The fullerene composition disclosed in the disclosure, wherein the fullerene is at least one of hollow fullerene, metal fullerene, heterocyclic fullerene and endohedral fullerene, and comprises fullerene C _2n Wherein n is more than or equal to 30 and less than or equal to 60; the fullerene is C ₆₀ 、C ₇₀ 、C ₇₆ 、C ₈₄ Or Gd@C ₈₂ The method comprises the steps of carrying out a first treatment on the surface of the The fullerene is C ₆₀ 。

The present disclosure also relates to a method of preparing a fullerene composition comprising the steps of: and (3) uniformly mixing fullerene powder and isododecane, treating by a high-pressure homogenizer, centrifuging and/or filtering to obtain a compound, and then compounding and dissolving the obtained fullerene compound and other components in the formula according to a proportion to obtain the fullerene composition disclosed by the disclosure.

The fullerene compositions of the present disclosure are useful for incorporation into personal care products, cosmetic or drug delivery systems, and/or sustained release systems.

The present disclosure also provides a personal care product composition, cosmetic composition, or pharmaceutical composition, characterized in that the personal care product composition, cosmetic composition, or pharmaceutical composition comprises the fullerene composition of any one of the foregoing.

Preferably, the personal care product composition, cosmetic composition or pharmaceutical composition is for hair care.

The present disclosure also relates to a method of preparing a personal care composition, cosmetic composition or pharmaceutical composition comprising the steps of: and (3) uniformly mixing fullerene powder and isododecane, treating by a high-pressure homogenizer, centrifuging and/or filtering to obtain a compound, mixing and dissolving the obtained fullerene compound with other components in a formula according to a proportion to obtain the fullerene composition disclosed by the disclosure, and uniformly mixing the fullerene composition with other components in the formula to obtain the personal care product composition, the cosmetic composition or the pharmaceutical composition.

Use of a fullerene composition according to any one of the preceding claims in the preparation of a personal care product composition, a cosmetic composition or a pharmaceutical composition for hair care.

Use of a fullerene composition according to any one of the preceding claims for the preparation of a personal care product composition, a cosmetic composition or a pharmaceutical composition for hair care.

Preferably, the hair care fingers of the present disclosure promote black growth.

Preferably, the hair care fingers of the present disclosure promote blackening of white hair.

Preferably, the hair care of the present disclosure refers to inhibiting white hair generation.

Use of a fullerene composition according to any one of the preceding claims for the preparation of a personal care composition, cosmetic composition or pharmaceutical composition for promoting the growth of black hair.

Use of a fullerene composition according to any one of the preceding claims for the preparation of a personal care product composition, cosmetic composition or pharmaceutical composition for promoting blackening of white hair.

Use of a fullerene composition according to any one of the preceding claims for the preparation of a personal care product composition, cosmetic composition or pharmaceutical composition for inhibiting the formation of white hair.

The fullerene composition of the present disclosure has the following advantages:

the raw materials of the fullerene composition can directly act on the scalp, are volatile and not easy to remain, and cannot cause secondary damage to the scalp; the fullerene composition disclosed by the disclosure can promote the fullerene to be absorbed and act on hair follicles more quickly so as to exert better drug effect; clinical tests prove that the hair care product prepared from the fullerene composition can remarkably improve scalp environment, the number of white hair roots blackening people is remarkably increased after the hair care product is used for 30 days, and the growth of white hair medulla can be remarkably promoted, wherein the effective rate of white hair blackening is 90%, the effective rate of scalp environment improvement is 100%, the effective rate of dandruff reduction is 96.7%, and the effective rate of hair remarkable thickening and brightening is 70% after the hair care product is used.

Drawings

FIG. 1 shows the care effect (photograph taken) of turning white hair to black after 30 days of use of a hair care product comprising the fullerene composition of the present disclosure

FIG. 2 illustrates the improvement effect on scalp environment after application 30 of a hair care product comprising the fullerene composition of the present disclosure

Fig. 3 illustrates the conditioning effect on reducing dandruff after 30 days of use of a hair care product comprising the fullerene composition of the present disclosure

Fig. 4 shows the care effect on the medulla of white hair after 30 days of use of a hair care product comprising the fullerene composition of the present disclosure

Detailed Description

In light of the foregoing disclosure, many other modifications, substitutions, or alterations are also possible in the form of modifications, substitutions, or alterations without departing from the spirit and scope of this disclosure.

The foregoing of the present disclosure will be described in further detail by way of the following detailed description of the embodiments. It should not be construed that the scope of the above subject matter of the present disclosure is limited to the following examples. All techniques implemented based on the foregoing disclosure are within the scope of the disclosure.

Definition of the definition

Throughout the specification and claims, unless explicitly stated otherwise, the term "comprise" or variations thereof such as "comprises" or "comprising", etc. will be understood to include the stated element or component without excluding other elements or components.

The term "pharmaceutically acceptable" refers to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit/risk ratio.

The terms "reduce", "inhibit", "alleviate", "reduce", "alleviate" or "remove" are used relative to a control. One skilled in the art will readily determine the appropriate controls for each experiment. For example, a reduced response in a subject or cell treated with the composition is compared to a response in a subject or cell not treated with the compound.

The use of the terms "promoting" or "increasing" is relative to a control. One skilled in the art will readily determine the appropriate controls for each experiment. For example, an elevated response in a subject or cell treated with the composition is compared to a response in a subject or cell not treated with the compound.

The term "personal care product composition" preferably includes general skin care and hair care products such as soaps, cleansing compositions, body washes, scalp cleansing creams, shampoos, scalp or hair essential oils, scalp or hair essences, hair films, hair conditioners, and the like. Also included are cosmetics such as creams, body milks, facial masks, cosmetics, decorative products and the like. The term "personal care composition" also includes cosmeceuticals and pharmaceutical products that are typically surface applied.

It should be understood that as used in this disclosure, the term "personal care article composition" refers to personal care articles and packages that are supplied to the consumer or user of the personal care article, either as a single product or as part of a package containing more than one personal care product.

The term "cosmetic composition" refers to use on healthy skin, healthy mucous membranes and/or healthy scalp for non-therapeutic purposes.

The term "pharmaceutical composition" means a composition comprising a fullerene and, depending on the mode of administration and the nature of the dosage form, at least one pharmaceutically acceptable ingredient selected from the group consisting of, but not limited to: carriers, diluents, adjuvants, excipients, preservatives, fillers, disintegrants, wetting agents, emulsifiers, suspending agents, sweeteners, flavoring agents, antibacterial agents, antifungal agents, lubricants, dispersing agents, temperature sensitive materials, temperature adjusting agents, adhesives, stabilizers, suspending agents, and the like.

In a known manner, the personal care product composition, cosmetic composition or pharmaceutical composition of the present disclosure may further comprise commonly used additives such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic additives, preservatives, antioxidants, solvents, fragrances, fillers, masking agents, odor absorbers and dyes. The amounts of these various additives are those conventionally used in the cosmetic field, and these additives may be incorporated into the fatty phase, the aqueous phase and/or the lipid globules according to the nature of the additives.

The terms "metallofullerene" and "endohedral fullerene" refer to a class of compounds having specific structures and properties, commonly referred to as endohedral fullerenes, typically using M@C, formed by incorporating various metals or metal clusters into the carbon cage structure of the fullerene _2n The form is represented, wherein M represents a metal element.

The terms "water-soluble fullerenes", "fullerene water-soluble modifications" refer to water-soluble modifications of fullerene particles such as hollow fullerenes, metal fullerene particles, and the like. The modified fullerene particles are externally modified with a plurality of water-soluble functional groups. The chemical functional groups contain one or more hydrophilic groups such as hydroxyl, carboxyl, sulfhydryl or amino or a combination thereof, so that the fullerene particles can be dissolved in water, or the metal fullerene or the derivative thereof can be directly modified by hydrophilic biological small molecules such as amino acid, peptide chain and the like, or the fullerene or the derivative thereof can be loaded by a carrier material with biocompatibility, such as liposome, cell membrane carrier and the like for coating, or a water-soluble supermolecular system and the like can be formed by self-assembly. The modification methods described above can all be modified according to the methods disclosed in the prior art.

Examples

The present disclosure is further illustrated below with reference to examples. The description of specific exemplary embodiments of the present disclosure is presented for purposes of illustration and description. The description is not intended to limit the disclosure to the precise form disclosed, and obviously many modifications and variations are possible in light of the teaching of the present specification. The exemplary embodiments were chosen and described in order to explain the specific principles of the present disclosure and its practical application to thereby enable one skilled in the art to make and utilize the present disclosure in various exemplary embodiments and with various modifications as are suited to the particular use contemplated.

The experimental methods used in the following examples are conventional methods unless otherwise specified.

Materials, reagents and the like used in the examples described below are commercially available unless otherwise specified.

Example 1: fullerene composition for hair care

The preparation method comprises the following steps:

and (3) taking fullerene powder and isododecane according to a formula, uniformly mixing, treating by a high-pressure homogenizer, centrifuging and/or filtering to obtain a compound, and then compounding and dissolving the obtained fullerene compound and other components in the formula according to a proportion to obtain the hair care composition.

Example 2: fullerene composition for hair care

The preparation method comprises the following steps: reference is made to the preparation of example 1.

Example 3: fullerene hair care essence oil

Example 4: fullerene hair care essence oil

The preparation method comprises the following steps:

the preparation method of reference example 1 comprises the steps of preparing a fullerene and isododecane compound, dissolving the obtained fullerene compound with isododecane, hydrogenated polyisobutene, caprylic/capric triglyceride, tocopheryl acetate, cocoyl caprylate/caprate and diethyl hexyl maleate in proportion, uniformly mixing the obtained fullerene compound with ginger oil and bisabolol, and adding menthol to dissolve the obtained fullerene compound to obtain the fullerene hair care essential oil.

Example 5: hair conditioner comprising fullerene composition of the present disclosure

The preparation method comprises the following steps:

1. adding the phase B into a main pot, stirring and heating to 85 ℃, preserving heat and stirring for 20min, wherein the stirring speed is 800-1000 r/min;

2. adding the phase A into an oil pot, stirring and heating to 85 ℃ until the phase A is completely dissolved;

3. adding the phase A into the phase B for homogenizing and emulsifying, emulsifying for 30min at 2000-2500 r/min, and cooling to 60-70 ℃;

4. adding the mixed C phase raw materials, homogenizing and emulsifying at 2000r/min for 20min, and cooling to 45 ℃;

5. adding the phase D raw material and stirring for 800-1000 r/min;

6. sequentially adding E, F phases, uniformly stirring for 20min, and discharging (pH=5.6-6.6 viscosity u=8000-13000 mpa.s).

Comparative example 1: fullerene and other grease compound preparation composition

The preparation method comprises the following steps: and (3) taking fullerene powder and squalane according to a formula, uniformly mixing, treating by a high-pressure homogenizer, centrifuging and/or filtering to obtain a compound preparation method, dissolving and compounding with other cosolvent in the formula, adding menthol after completely uniformity, and dissolving completely to obtain the fullerene compound for scalp.

Comparative example 2: fullerene and other grease compound preparation composition

The preparation method comprises the following steps: after the fullerene composition is obtained by the preparation method of the example 1, the fullerene composition is dissolved and compounded with other cosolvents in a formula, menthol is added after the fullerene composition is completely and uniformly dissolved, and the fullerene compound for scalp is obtained after the fullerene composition is completely dissolved.

Comparative example 3: fullerene and other grease compound preparation composition

Effect example 1: skin feel test

Test sample:

no. 1-Fullerene composition prepared in example 4,

No. 2-fullerene jojoba seed oil,

3 # Fullerene pond flower seed oil,

No. 4-Fullerene olive oil ester,

No. 5-Fullerene ethylhexyl palmitate,

6 # Fullerene caprylic capric triglyceride,

No. 7-fullerene seabuckthorn seed oil,

No. 8-fullerene silk oil

The testing method comprises the following steps: the hands of 20 volunteers were thoroughly cleaned before the raw materials were tried, and scoring was performed after one raw material was applied.

Test standard: volunteer experiences are recorded in a questionnaire form, the good absorption is 8-10 minutes, the absorption is generally 5-8 minutes, and the absorption difference is 2-5 minutes; the skin feel was excellent, superior, general, and the results are shown in table 1.

TABLE 1 skin feel test of different oil soluble adjuvants and Fullerene formulations

Conclusion: the product No. 1 has the advantages of optimal skin feel, optimal absorbency, better skin feel No. 2, 3, 6 and 7, good absorbency, greasy skin feel No. 4 and 5, general feel and poor absorbency.

Effect example 2: fullerene composition physical property test of the present disclosure

The fullerene composition prepared in example 4 was hermetically packaged in 50ml penicillin bottles for examination.

Detection conditions: heating at 45deg.C, cold preserving at 25deg.C and 4deg.C, freezing at-20deg.C, and cold-hot circulating experiment for 30 days.

Detecting items: detecting the phase and smell change of the product;

detection standard:

sex phase: whether the product is layered, whether precipitation occurs, and whether the color changes

Taste change: whether the product changes after smelling or not is changed, the original product has no obvious smell, if the product changes, the grease can be rancid and has a pungent taste.

TABLE 2 Fullerene composition property test results of the present disclosure

Conclusion: after 30 days of examination, the product phase was unchanged and the taste was unchanged under each test condition.

Effect example 3: care effects of hair care products prepared from the fullerene compositions of the present disclosure

1) Criteria for inclusion

Male and female aged 18-65 years

Has obvious white hair in appearance

Has no chemical treatment such as perming, bleaching, dyeing, etc. within one week

The male hair must be longer than 3cm in length.

The test process can be read and understood, and the informed consent can be signed in a written manner;

can promise to complete the specified content according to the requirements of the test scheme.

2) Experimental grouping and mode of use:

experiments detect that the scalp environment obviously improves the number of people, the nursing of dandruff, the blackening of roots of 1 week, the blackening of white hair roots of 30 days and the growing of white hair medulla

Control group: example 4 composition sample set after fullerene removal (30 persons);

experimental group: sample sets (30 persons) of fullerene compositions prepared using example 4;

the using method comprises the following steps: 2 times per week for 1.5 hours. During the period, other similar cosmetics cannot be used, the trial standard is strictly adhered to, and objective, real and reliable results are ensured.

Experimental period: for 30 days

3) Statistical method

Effective criteria:

white to black: the method is effective for reducing the number of white hairs at the same part by 30% before and after use, and is lower than that of the method

Scalp environment significantly improves the number of people: the scalp reddening area of the same part is reduced by 20 percent according to the use before and after the use, which is lower than that of the scalp reddening area of the same part

Dandruff nursing: according to the judging basis of whether the same part has dandruff or not before and after use, whether the same part has dandruff or not is effective or not;

the number of people with growing grey hair medulla: the hair growth is effective and the hair is not ineffective according to whether the hair growth of the medulla of the same part is standard before and after the use.

4) Experimental results (table 3)

Under the cooperation of 30 patients, the clinical detection is successfully completed, 0 person uses the product group without fullerene to effectively use, and 27 persons use the product group with fullerene to change the hair root from white to black, so that the effective rate reaches 90%.

Table 3, care effects and experimental results statistics of hair care products prepared with the fullerene compositions of the present disclosure

Conclusion: as can be seen from table 3 above, the hair care product prepared from the fullerene composition of the present disclosure has excellent care effects in scalp environment for significantly improving the number of people, 7 days of white hair root blackening, 30 days of white hair root blackening, and white hair medulla growth:

white hair to black subgroup: the clinical detection of each group is successfully completed under the cooperation of 30 patients, 0 person uses the product group without fullerene to effectively use, and 27 persons use the product group with water-soluble fullerene to change the hair root from white to black (figure 1), so that the effective rate reaches 90%.

Scalp environment significantly improves subgroups:

the clinical detection of each group is successfully completed under the cooperation of 30 patients, 4 people effectively use the product group without fullerene, and in the product group with water-soluble fullerene, the oil at hair follicles is obviously reduced (figure 2) and the scalp itching feeling disappears after 30 people use, so that the effective rate reaches 100%.

Dandruff care subgroup:

with the cooperation of 30 patients, the clinical detection is successfully completed, 2 people in the group with the product without fullerene are effective, and 29 people in the group with the product with water-soluble fullerene have no dandruff after use (figure 3), and the effective rate is 96.7%.

White hair grows into the medullary subgroup:

with the cooperation of 30 patients in each group, the clinical detection is successfully completed, 0 person uses the product group without fullerene to effectively use, and 21 persons use the product group with water-soluble fullerene to obviously thicken and lighten hair (figure 4), so that the effective rate reaches 70%.

Claims

1. A fullerene composition, characterized in that the composition consists of fullerene, isododecane, hydrogenated polyisobutene, tocopheryl acetate, caprylic capric triglyceride, diethyl hexyl maleate, cocoyl caprylate/caprate, bisabolol, ginger oil and menthol;

wherein the mass ratio of fullerene, isododecane, hydrogenated polyisobutene, caprylic capric triglyceride, diethyl hexyl maleate, cocoyl caprylate/caprate, tocopheryl acetate, bisabolol and ginger oil in the composition is (0.01-10): (5-60): (0.01-5): (0.5-10): (1-40): (1-40): (0.1-20): (0.01-2): (0.01-2);

the mass ratio of menthol to fullerene is (0.01-10): (0.01-10).

2. The fullerene composition according to claim 1, wherein the mass ratio of fullerene, isododecane, hydrogenated polyisobutene, caprylic capric triglyceride, diethyl hexyl maleate, coco caprylate/caprate, tocopheryl acetate, bisabolol and ginger oil in the composition is (0.01-10): (10-50): (0.05-4): (1-8): (2-30): (2-30): (1-15): (0.05-1.5): (0.05-1.5).

3. The fullerene composition according to claim 1, wherein the mass ratio of fullerene, isododecane, hydrogenated polyisobutene, caprylic capric triglyceride, diethyl hexyl maleate, cocoyl caprylate/caprate tocopheryl acetate, bisabolol and ginger oil in the composition is (0.05-3): (20-40): (0.05-2): (1-5): (5-20): (5-20): (1-10): (0.05-1): (0.05-1).

4. The fullerene composition according to claim 1, wherein the mass ratio of menthol added to fullerene is (0.05-8): (0.01-10).

5. The fullerene composition according to claim 1, wherein the mass ratio of menthol added to fullerene is (1-5): (0.05-3).

6. The fullerene composition according to any one of claims 1-5, wherein the fullerene is a hollow fullerene.

7. The fullerene composition according to any one of claims 1-5, wherein the fullerene is a metallofullerene.

8. The fullerene composition according to any one of claims 1-5, wherein the fullerene is a heterocyclic fullerene.

9. The fullerene composition according to any one of claims 1-5, wherein the fullerene is an endohedral fullerene.

10. The fullerene composition according to any one of claims 1-5, wherein the fullerene comprises fullerene C _2n Wherein n is more than or equal to 30 and less than or equal to 60.

11. The fullerene composition according to any one of claims 1-5, wherein the fullerene is C ₆₀ 、C ₇₀ 、C ₇₆ 、C ₈₄ Or Gd@C ₈₂ 。

12. The fullerene composition according to any one of claims 1-5, wherein the composition is incorporated into a personal care product or a drug delivery system and/or a slow release system.

13. The fullerene composition according to claim 6, wherein the composition is incorporated into a personal care product or a drug delivery system and/or a slow release system.

14. The fullerene composition according to claim 7, wherein the composition is incorporated into a personal care product or a drug delivery system and/or a slow release system.

15. The fullerene composition according to claim 8, wherein the composition is incorporated into a personal care product or a drug delivery system and/or a slow release system.

16. The fullerene composition according to claim 9, wherein the composition is incorporated into a personal care product or a drug delivery system and/or a slow release system.

17. The fullerene composition according to claim 10, wherein the composition is incorporated into a personal care product or a drug delivery system and/or a slow release system.

18. The fullerene composition according to claim 11, wherein the composition is incorporated into a personal care product or a drug delivery system and/or a slow release system.

19. A personal care product composition or pharmaceutical composition comprising the fullerene composition according to any one of claims 1 to 18.

20. Use of a fullerene composition according to any one of claims 1 to 18 for the preparation of a personal care product composition or a pharmaceutical composition for hair care.

21. The use according to claim 20, wherein the hair care means promoting the growth of black or promoting the blackening of white hair or inhibiting the formation of white hair.