CN1135983C - 二酸(5-雄甾烯-17-酮-3β-羟基)二酯用于制备药物 - Google Patents
二酸(5-雄甾烯-17-酮-3β-羟基)二酯用于制备药物 Download PDFInfo
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- CN1135983C CN1135983C CNB011148640A CN01114864A CN1135983C CN 1135983 C CN1135983 C CN 1135983C CN B011148640 A CNB011148640 A CN B011148640A CN 01114864 A CN01114864 A CN 01114864A CN 1135983 C CN1135983 C CN 1135983C
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- SXYFKXOFMCIXQW-UHFFFAOYSA-N propanedioyl dichloride Chemical compound ClC(=O)CC(Cl)=O SXYFKXOFMCIXQW-UHFFFAOYSA-N 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
组别(mg/kg) | Aco的用量(μg.kg-1) | |||
VP VT VF CA | ||||
CMC-Na化合物C 0.5化合物D 0.5化合物E 0.5Pras 4.5胺腆酮 3 | 65.5±15.298.0±29.1**122.4±20.5**108.2±37.4**93.5±19.0**90.0±25.7* | 84.6±30.1118.9±35.3*137.8±24.4*122.4±37.8*110.0±16.1*108.8±25.4 | 121.4±28.0152.8±39.3*186.4±30.2*163.4±30.5**132.7±24.4141.2±28.2 | 148.2±33.0186.5±31.7*204.0±28.0*184.5±27.1*164.5±27.1176.0±38.0* |
组别(mg/kg) | 恢复窦性心律时间(min) | 窦性心律维持时间(min) |
CMC-Na | 38.648±8.142 | 21.482±8.041 |
化合物I 0.5 | 6.752±4.123*** | 45.478±5.271*** |
化合物J 1.5 | 3.584±2.471*** | 51.762±6.275*** |
化合物J 2.5 | 0.845±1.529*** | 59.248±1.527*** |
胺腆酮 3 | 15.859±5.126*** | 40.156±5.124*** |
组别 | 相对骨体积/% | 单位面积骨小梁内细胞数 | 平均骨小梁宽度/μm |
空白组模型组罗钙全组化合物C组化合物D组化合物E组化合物F组化合物G组化合物H组化合物I组化合物J组 | 38.57±3.25***22.63±3.1536.72±7.82***38.94±3.73***41.55±4.38***35.87±3.12***37.14±3.46***34.37±3.27***38.31±3.55***29.84±3.56***37.55±3.26*** | 15.75±4.21*12.71±4.3619.27±3.89**19.50±5.54*20.70±5.27***19.35±3.13**26.31±3.16***25.84±3.31***35.69±3.70***31.84±3.94***29.84±3.16*** | 68.61±10.21**44.91±18.7267.16±13.11**72.69±10.38***70.76±8.56***68.66±9.80***74.67±3.56***69.67±3.15**60.84±4.81*61.37±4.71*67.84±4.68* |
Claims (1)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011148640A CN1135983C (zh) | 2001-06-28 | 2001-06-28 | 二酸(5-雄甾烯-17-酮-3β-羟基)二酯用于制备药物 |
PCT/CN2002/000364 WO2003002124A1 (fr) | 2001-06-28 | 2002-05-29 | Utilisation de bis-acide(5-androsten-17-one-3$g(b)-hydroxyl)diesters pour la production de produits pharmaceutiques |
US10/480,173 US20040171594A1 (en) | 2001-06-28 | 2002-05-29 | Use of bis-acid(5-androsten-17-one-3beta-hydroxyl)diester for manufacture pharmaceuticals |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011148640A CN1135983C (zh) | 2001-06-28 | 2001-06-28 | 二酸(5-雄甾烯-17-酮-3β-羟基)二酯用于制备药物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1348764A CN1348764A (zh) | 2002-05-15 |
CN1135983C true CN1135983C (zh) | 2004-01-28 |
Family
ID=4661472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB011148640A Expired - Fee Related CN1135983C (zh) | 2001-06-28 | 2001-06-28 | 二酸(5-雄甾烯-17-酮-3β-羟基)二酯用于制备药物 |
Country Status (3)
Country | Link |
---|---|
US (1) | US20040171594A1 (zh) |
CN (1) | CN1135983C (zh) |
WO (1) | WO2003002124A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2853318A1 (fr) * | 2003-04-07 | 2004-10-08 | Mayoly Spindler | Nouveaux procedes de preparation de derives de la dhea |
CN101081213B (zh) * | 2007-06-26 | 2010-10-06 | 中山大学 | 丁二酸(5-雄甾烯-17-酮-3β-羟基)二酯固体分散体及其制备方法与应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9002278L (sv) * | 1990-06-28 | 1991-12-29 | Perstorp Ab | Anvaendning av inositoltrisfosfat foer framstaellning av ett laekemedel |
JP4598203B2 (ja) * | 1995-12-01 | 2010-12-15 | ビーティージー・インターナショナル・リミテッド | 脳機能改善剤 |
US6080788A (en) * | 1997-03-27 | 2000-06-27 | Sole; Michael J. | Composition for improvement of cellular nutrition and mitochondrial energetics |
US5807554A (en) * | 1997-04-11 | 1998-09-15 | Yng-Wong; Quing Non | Herbal formulations with nacre |
CN1089586C (zh) * | 1997-07-18 | 2002-08-28 | 中山大学 | 二酸(5-雄甾烯-17-酮-3β-羟基)酯及其用于制备药物 |
US5972894A (en) * | 1997-08-07 | 1999-10-26 | Cytran, Inc. | Peptides having potassium channel opener activity |
-
2001
- 2001-06-28 CN CNB011148640A patent/CN1135983C/zh not_active Expired - Fee Related
-
2002
- 2002-05-29 US US10/480,173 patent/US20040171594A1/en not_active Abandoned
- 2002-05-29 WO PCT/CN2002/000364 patent/WO2003002124A1/zh not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2003002124A1 (fr) | 2003-01-09 |
CN1348764A (zh) | 2002-05-15 |
US20040171594A1 (en) | 2004-09-02 |
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