CN113577374A

CN113577374A - Composite liquid band-aid and preparation method thereof

Info

Publication number: CN113577374A
Application number: CN202110843062.9A
Authority: CN
Inventors: 杨鑫; 马超
Original assignee: Harbin Beckard Sugar Biotechnology Co ltd
Current assignee: Harbin Beckard Sugar Biotechnology Co ltd
Priority date: 2021-07-26
Filing date: 2021-07-26
Publication date: 2021-11-02

Abstract

A compound liquid band-aid and its preparation method are provided. The invention belongs to the field of medical dressings. The invention aims to solve the technical problems of high skin irritation and poor tensile property of the existing liquid band-aid. The compound liquid band-aid is prepared from chitosan derivatives, sodium carboxymethylcellulose, chitosan oligosaccharide, pseudo-ginseng extract, vitamin K, glycerol and the balance of water. The method comprises the following steps: firstly, carrying out ultrasonic extraction on pseudo-ginseng by using ethanol to obtain a pseudo-ginseng extract concentrated solution; then adding sodium carboxymethylcellulose, chitosan derivatives and chitosan oligosaccharide into water respectively, and stirring for dissolving to obtain a solution; and finally, mixing the solutions, adding vitamin K, glycerol and water, and uniformly mixing to obtain the compound liquid band-aid. The liquid band-aid has the advantages of innovative formula, low manufacturing cost, simple preparation process, quick film forming after being coated, high film forming speed, good isolation, low irritation and the like, and can play the role of the liquid band-aid by coating.

Description

Composite liquid band-aid and preparation method thereof

Technical Field

The invention belongs to the field of medical dressings, and particularly relates to a composite liquid band-aid and a preparation method thereof.

Background

The adhesive bandage is a common trauma dressing, which is composed of a long adhesive plaster and a small yarn strip soaked with medicine attached in the middle, and is often widely applied to the treatment of wounds on the surface layer of human skin. Although convenient to use, the band-aid has some disadvantages, such as the airtight of the outer adhesive tape, which can cause the skin of the wound and the surrounding of the wound to become white, easily cause the bacterial accumulation at the wound, further cause the wound infection, and influence the healing speed at the wound. Meanwhile, the shape of the band-aid is fixed, so that the band-aid only can be used for certain wounds with small areas, and the band-aid is difficult to play a role in certain wounds with irregular shapes or large wounds. Therefore, the emergence of liquid band-aids is inevitable based on the above problems.

The liquid band-aid is a modern medical dressing, mainly comprises components such as a film-forming material, an antibacterial agent, a plasticizer and the like, and can form a layer of covering film on the surface of a wound, so that the wound is isolated from the external environment, the wound is prevented from contacting bacteria or other microorganisms in the air, and further infection is avoided. The liquid band-aid can also cover wounds in any shapes, has no shape limitation and is convenient to use; after the film is formed, the normal activity of a patient is not influenced, the film cannot be adhered to clothes, and the use is convenient. However, the common film-forming component in the formula of the existing liquid band-aid is a chemical synthetic material, so that the common film-forming component has large irritation to the skin, and further use of the common film-forming component in skin wounds of children is limited. The single biomaterial has poor tensile properties in use, which limits its use. Therefore, a preparation method of the compound liquid band-aid with high film forming speed, good air permeability and low irritation is urgently needed.

Disclosure of Invention

The invention aims to solve the technical problems of large skin irritation and poor tensile property of the existing liquid band-aid, and provides a composite liquid band-aid and a preparation method thereof.

The compound liquid band-aid is prepared from 1-10% of chitosan derivative, 1-10% of sodium carboxymethylcellulose, 1-5% of chitosan oligosaccharide, 1-5% of pseudo-ginseng extract, 0-10% of vitamin K1, and the balance of water by mass.

Further limited, the compound liquid band-aid is prepared from 4% of chitosan derivative, 6% of sodium carboxymethyl cellulose, 5% of chitosan oligosaccharide, 5% of pseudo-ginseng extract, 5% of vitamin K, 5% of glycerol and 70% of water by mass fraction.

Further limited, the compound liquid band-aid is prepared from 4% of chitosan derivative, 6% of sodium carboxymethyl cellulose, 5% of chitosan oligosaccharide, 5% of pseudo-ginseng extract, 5% of vitamin K and 75% of water by mass fraction.

Further limiting, the chitosan derivative is one or a mixture of several of carboxymethyl chitosan, quaternary ammonium salt chitosan and hydroxypropyl chitosan according to any ratio.

Further limiting, the polymerization degree of the chitosan oligosaccharide is 2-6.

The preparation method of the composite liquid band-aid is carried out according to the following steps:

step 1: pulverizing Notoginseng radix, sieving, ultrasonic extracting with ethanol for several times, mixing extractive solutions, and concentrating by rotary evaporation to obtain Notoginseng radix extract concentrated solution;

step 2: adding sodium carboxymethylcellulose into water, stirring and dissolving to obtain sodium carboxymethylcellulose solution;

and step 3: adding the chitosan derivative into water, stirring and dissolving to obtain a chitosan derivative solution;

and 4, step 4: adding chitosan oligosaccharide into water, stirring and dissolving to obtain a chitosan oligosaccharide solution;

and 5: and uniformly mixing the pseudo-ginseng extract concentrated solution, the chitosan derivative solution, the sodium carboxymethylcellulose solution and the chitosan oligosaccharide solution, then adding vitamin K, glycerol and water, and uniformly mixing to obtain the compound liquid band-aid.

Further defined, the mass concentration of the ethanol in the step 1 is 95%.

Further limited, the number of times of the ultrasonic extraction in step 1 is 3.

Further limiting, the frequency of the ultrasonic extraction in the step 1 is 15 kHz-25 kHz, and the time of each extraction is 15 min-25 min.

Further, the concentration of the sodium carboxymethyl cellulose solution in the step 2 is 0.04 g/mL-0.4 g/mL.

Further, the concentration of the chitosan derivative solution in step 3 is 0.04 g/mL-0.4 g/mL.

Further limiting, the concentration of the chitosan oligosaccharide solution in the step 4 is 0.04 g/mL-0.2 g/mL.

Compared with the prior art, the invention has the following advantages:

1) according to the formula, the chitosan derivative and the sodium carboxymethyl cellulose have synergistic interaction, so that the film forming speed is high, the film is not easy to damage, the film has good adhesion to skin, the wound surface can be covered, and secondary damage to the wound due to the excessively strong adhesion can be avoided. Compared with the single component, the composite material of the two components improves the tensile property, and in addition, the formula of the invention does not introduce irritant solvents such as ethanol and the like, and has good comfort when in use.

2) In the formula of the invention, the chitosan oligosaccharide is a polysaccharide substance with positive charges, amino positive ions in the structure of the chitosan oligosaccharide can generate electrostatic interaction with cell membranes with negative charges, and can inhibit the growth of bacteria, thereby achieving the bactericidal effect, and the panax notoginseng extract comprises saponin, flavonoid glycoside, amino acid and the like, and has the anti-inflammatory and analgesic effects.

3) In the formula of the invention, glycerin is used as a common plasticizer, so that the film is softer and can moisten skin, the film has good moisture retention, the wound is promoted to heal quickly, and the tightness of the film formed on the surface of the wound can be relieved. Vitamin K has the function of promoting blood coagulation and can therefore be used as a blood coagulation component in the formulation of the present invention.

4) According to the formula, the chitosan derivative and the amino and carboxyl in the sodium carboxymethyl cellulose can form a hydrogen bond effect, and electrostatic interaction exists, so that two polymer chains are wound and crosslinked, and a plurality of hole structures exist in the microstructure of the liquid band-aid.

5) The liquid band-aid has the advantages of innovative formula, low manufacturing cost and simple preparation process, can play the role of the liquid band-aid by smearing, can quickly form a film after smearing, and achieves the optimal effects of resisting bacteria, diminishing inflammation, keeping moisture, comforting and coagulating and healing at low cost and small using amount by reasonably regulating and controlling the content ratio of each component in the formula.

Drawings

FIG. 1 is a microstructure view of the composite liquid band-aid of example 1;

FIG. 2 is a graph showing the results of the swelling experiment of the complex liquid band-aid of examples 1-4.

Detailed Description

Example 1, the composite liquid band-aid of the present example is prepared from, by mass, 2% of carboxymethyl chitosan, 8% of sodium carboxymethyl cellulose, 5% of chitosan oligosaccharide, 5% of a notoginseng extract, 5% of vitamin K, 5% of glycerol, and 70% of water, wherein the degree of polymerization of the chitosan oligosaccharide is 2-6.

The method for preparing the composite liquid band-aid of example 1 is carried out according to the following steps:

step 1: pulverizing Notoginseng radix, sieving, ultrasonic extracting with 95% ethanol at 20kHz for 3 times (20 min each time), mixing extractive solutions, and concentrating by rotary evaporation to obtain Notoginseng radix extract concentrate with concentration of 0.167 g/mL;

step 2: adding sodium carboxymethylcellulose into water, stirring and dissolving to obtain a sodium carboxymethylcellulose solution with the concentration of 0.32 g/mL;

and step 3: adding carboxymethyl chitosan into water, stirring and dissolving to obtain a carboxymethyl chitosan solution with the concentration of 0.08 g/mL;

and 4, step 4: adding chitosan oligosaccharide into water, stirring and dissolving to obtain a chitosan oligosaccharide solution with the concentration of 0.2 g/mL;

Example 2, this example is different from example 1 in that: the content of carboxymethyl chitosan in the product is 4 wt%, and the content of sodium carboxymethyl cellulose is 6 wt%; in the method, the concentration of the sodium carboxymethyl cellulose solution is 0.24g/mL, the concentration of the carboxymethyl chitosan is 0.16g/mL, and other steps and parameters are the same as those of the embodiment 1.

Example 3, this example is different from example 1 in that: the content of carboxymethyl chitosan in the product is 6 wt%, and the content of sodium carboxymethyl cellulose is 4 wt%; in the method, the concentration of the sodium carboxymethyl cellulose solution is 0.16g/mL, the concentration of the carboxymethyl chitosan is 0.24g/mL, and other steps and parameters are the same as those of the embodiment 1.

Example 4, this example is different from example 1 in that: the content of carboxymethyl chitosan in the product is 8 wt%, and the content of sodium carboxymethyl cellulose is 2 wt%; in the method, the concentration of the sodium carboxymethyl cellulose solution is 0.08g/mL, the concentration of the carboxymethyl chitosan is 0.32g/mL, and other steps and parameters are the same as those of the embodiment 1.

Example 5, this example is different from example 1 in that: the chitosan derivative was prepared by replacing carboxymethyl chitosan with chitosan quaternary ammonium salt, and the other steps and parameters were the same as in example 1.

Example 6, this example is different from example 1 in that: the chitosan derivative was substituted with carboxymethyl chitosan by hydroxypropyl chitosan, and the other steps and parameters were the same as in example 1.

Detection test

Test one: microstructure

Fig. 1 is a scanning electron microscope image of a freeze-dried sample of the composite liquid band-aid of example 1. As shown in fig. 1, the microstructure of the liquid adhesive bandage after freeze-drying is an irregular porous structure, and the existence of the porous structure provides a good place for the exchange of water vapor in the air, so that the liquid adhesive bandage has certain air permeability.

And (2) test II: swelling property

The swelling property is an important index for evaluating the liquid absorption capacity of the material, good swelling property can absorb tissue fluid exuded from a wound, the tissue fluid is prevented from being accumulated on the wound surface, and the recovery speed of the wound is influenced. FIG. 2 shows the swelling degree of different samples. From the test results, it can be seen that the film formed by the composite liquid band-aid of the invention can absorb more than 10 times of the liquid by the weight of the film, which indicates that the film has good swelling performance.

And (3) test III: mechanical property of liquid band-aid after film forming

As a medical dressing, the tensile strength and the elongation at break of a material are key indexes reflecting the plasticity of the material, the sufficient tensile strength is favorable for the material to better keep the original appearance and structural integrity of the material in use, the test is carried out according to the test method of GB13022-1991 by using a universal mechanical material testing machine, the composite liquid adhesive film of the embodiment 1-4 is cut into a rectangle of 40mm multiplied by 20mm for testing, the material is fixed by using a test clamp, the distance between the upper clamp and the lower clamp is 20mm for testing, the tensile test is carried out at the speed of 0.1mm/min, and the tensile strength and the elongation at break of the composite film are calculated according to the maximum tensile force and displacement. The test results are shown in table 1.

TABLE 1 tensile Properties

	Example 1	Example 2	Example 3	Example 4
					Tensile Strength (kPa)	67.2	126.4	133.2	229.4
Elongation at Break (%)	39.25	38.3	59.8	60.65

From the results of Table 1, it can be found that the carboxymethyl chitosan composite film has a tensile strength of 229.4kPa at maximum and an elongation at break of 60.65% at maximum. The composite system is formed by the interaction of hydrogen bonds between the carboxymethyl chitosan and the sodium carboxymethyl cellulose. The tensile strength represents the strength of the toughness of the material, and the hydrogen bond has the function of toughening and modifying, so that the tensile strength and the elongation at break of the carboxymethyl chitosan composite film are higher, and simultaneously, when the content of the carboxymethyl chitosan is increased, the number of chemical groups participating in crosslinking is increased, the hydrogen bond function is enhanced, and the mechanical property of the composite film is improved.

Claims

1. The compound liquid band-aid is characterized by being prepared from 1-10% of chitosan derivative, 1-10% of sodium carboxymethylcellulose, 1-5% of chitosan oligosaccharide, 1-5% of pseudo-ginseng extract, 0-10% of vitamin K1, 0-10% of glycerol and the balance of water by mass.

2. The compound liquid band-aid according to claim 1, wherein the compound liquid band-aid is prepared from 4% of chitosan derivative, 6% of sodium carboxymethyl cellulose, 5% of chitosan oligosaccharide, 5% of panax notoginseng extract, 5% of vitamin K, 5% of glycerin and 70% of water by mass fraction.

3. The compound liquid band-aid according to claim 1, wherein the compound liquid band-aid is prepared from 4% of chitosan derivative, 6% of sodium carboxymethyl cellulose, 5% of chitosan oligosaccharide, 5% of panax notoginseng extract, 5% of vitamin K and 75% of water by mass fraction.

4. The compound liquid band-aid according to claim 1, wherein the chitosan derivative is one or a mixture of several of carboxymethyl chitosan, quaternary ammonium salt chitosan and hydroxypropyl chitosan.

5. The compound liquid band-aid according to claim 1, wherein the degree of polymerization of the chitosan oligosaccharide is 2-6.

6. The preparation method of the compound liquid woundplast as claimed in any one of claims 1-5, wherein the preparation method comprises the following steps:

7. The preparation method of the compound liquid woundplast as claimed in claim 6, wherein the mass concentration of ethanol in step 1 is 95%, the number of times of ultrasonic extraction in step 1 is 3, the frequency of ultrasonic extraction in step 1 is 15 kHz-25 kHz, and the time of each extraction is 15 min-25 min.

8. The method for preparing the compound liquid woundplast according to claim 6, wherein the concentration of the sodium carboxymethyl cellulose solution in step 2 is 0.04g/mL to 0.4 g/mL.

9. The method for preparing a compound liquid woundplast according to claim 6, wherein the concentration of the chitosan derivative solution in step 3 is 0.04 g/mL-0.4 g/mL.

10. The method for preparing a compound liquid woundplast according to claim 6, wherein the concentration of the chitosan oligosaccharide solution in step 4 is 0.04 g/mL-0.2 g/mL.