CN113559320B - Multi-scale fiber negative Poisson ratio three-dimensional conductive melt-blown non-woven fabric myocardial patch - Google Patents
Multi-scale fiber negative Poisson ratio three-dimensional conductive melt-blown non-woven fabric myocardial patch Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/08—Melt spinning methods
- D01D5/098—Melt spinning methods with simultaneous stretching
- D01D5/0985—Melt spinning methods with simultaneous stretching by means of a flowing gas (e.g. melt-blowing)
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
- D01F8/16—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one other macromolecular compound obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds as constituent
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4382—Stretched reticular film fibres; Composite fibres; Mixed fibres; Ultrafine fibres; Fibres for artificial leather
- D04H1/43838—Ultrafine fibres, e.g. microfibres
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/54—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving
- D04H1/56—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving in association with fibre formation, e.g. immediately following extrusion of staple fibres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
Abstract
The invention discloses a multi-scale fiber negative Poisson ratio three-dimensional conductive melt-blown non-woven fabric myocardial patch, which is prepared by taking a shape memory polymer with a conductive function as a raw material and adopting a melt-blown non-woven fabric processing method to obtain a non-woven fabric with mixed fiber distribution of nano-micron mixed scale, and can better simulate a nano-micron fiber network structure of myocardial tissue extracellular matrix (ECM). The non-woven fabric is formed by overlapping a plurality of layers of fiber webs, wherein the nano-micron fibers have certain directionality and are matched with the laminated structures of the myocardial tissues in the long axis direction and the short axis direction and the ordered arrangement structure of the ECM, and the structure and the performance of the non-woven fabric are changed in a negative Poisson ratio. The melt-blown non-woven fabric also has good electrical conductivity, a stable signal conduction function, an elastic deformation function and good mechanical properties, and the negative Poisson ratio under different strains can be matched with the negative Poisson ratio deformation of contraction and relaxation of myocardial tissues, so that the myocardial tissues can be well simulated.
Description
Technical Field
The invention relates to a multi-scale fiber negative Poisson ratio three-dimensional conductive melt-blown non-woven fabric myocardial patch.
Background
Myocardial infarction seriously threatens human health and life, and brings heavy burden to society and families. The current treatment mode for myocardial infarction is not ideal. After myocardial infarction occurs, damaged myocardial cells die irreversibly and are further replaced by compact collagen scar tissues, and the surviving myocardial cells cannot supplement lost cells through proliferation and differentiation of the surviving myocardial cells and only can cause remodeling and expansion of the left ventricle through compensatory hypertrophy, so that heart failure occurs. The myocardial tissue has different structures and performances in the directions of a long axis and a short axis, has an anisotropic structure, and shows a negative Poisson ratio effect in the directions of the long axis and the short axis. Therefore, replacement of scar tissue by reconstruction of functional myocardium by regenerative medical means would be an ideal way to effectively restore cardiac function.
The use of engineered myocardial patches for the treatment of myocardial infarction is a promising approach. The patch needs to be able to mimic the structure of the native myocardium and have functions such as inducing cardiomyocyte attachment and growth, promoting myocardial functionalization in vitro, and repairing infarct sites in vivo. An ideal myocardial patch should have the following characteristics: 1. the stent material has good elasticity, extensibility, stability, plasticity and certain mechanical strength, and the stent cannot be damaged by the beating of essential muscle cells. 2. Has good biocompatibility and does not cause inflammatory reaction, toxic reaction and immunological rejection reaction in vivo. 3. The myocardial patch has the capability of synchronous contraction and good conductivity for biological electric conduction and avoids serious arrhythmia after being transplanted in vivo.
The melt-blown method is developed in the 50 th of the 20 th century, and the production process is that polymer slices with high melt index are adopted, extruded and heated by a screw rod to be melted into high-temperature melt with good flowing property, and then the melt fine flow sprayed from a spinneret plate is blown away into fine fibers by high-temperature and high-speed hot air flow, and the fine fibers are gathered into a fiber web on a receiving device and are mutually bonded and entangled to form cloth by utilizing the self waste heat.
The melt is drawn into filaments with fineness of only 1-5 μm under the action of the high-temperature and high-speed airflow, and meanwhile, the fine filaments are broken into short fibers with the fineness of 40-70mm by the drawing airflow. Then the short fibers fall on the web forming machine under the guidance of the drafting airflow and are bonded with each other on the web forming machine by the residual heat of the short fibers, so that a continuous fiber web is formed. After a continuous fiber web is formed on a web forming machine, the continuous fiber web is wound into a roll by a winding machine and is cut by a cutting machine, and finally a melt-blown non-woven fabric product is formed.
The melt-blown non-woven technology is an important means for manufacturing nano-fiber materials at present, and has the remarkable characteristics of short process flow, simple equipment and fine fiber (the fiber diameter can reach micron-scale or even sub-nanometer-scale). The melt-blown nonwoven fabric is mainly used as a composite material, a filter material, a heat insulation material, a sanitary product, an oil absorption material, a cleaning cloth (wiping cloth), a battery diaphragm and the like, and is widely applied to the fields of medical treatment and health, the automobile industry, the filter material, environmental protection and the like. In foreign countries, meltblown nonwovens are mainly used as two-step SMS materials and materials for medical hygiene and as coating materials, and also wiping and absorbing materials, filtration and barrier materials are important applications for meltblown webs.
The high-speed hot air blowing method can be used for preparing the melt-blown nano/micron non-woven fabric for air filtration, and the fiber diameter is 200nm-10 mu m. The diameter of the fiber can be rapidly reduced by high-speed hot air strong drawing, and the multi-scale fiber is prepared. During air-drawing, the fibers preferentially align in the MD, forming an ordered structure. The negative Poisson's ratio effect of the non-woven fabric can be realized by regulating and controlling fiber arrangement, pores and a layered structure and showing anisotropic change, gamma is-0.80 +/-0.3 under the condition of 5 percent of unidirectional strain, meets the negative Poisson's ratio deformation requirement of the myocardial patch, and has the remarkable effects of reducing wall stress and relieving hypertrophy.
The scaffold for constructing the tissue engineering myocardial patch has high porosity, good mechanical property, biodegradability and biocompatibility and can provide a microenvironment similar to extracellular matrix. The material for constructing the tissue engineering myocardial patch comprises natural materials (collagen, fibrin, chitosan, natural ECM, polypeptide and the like) and artificial synthetic materials (PCL). The nanometer-micrometer fiber non-woven fabric can be prepared by a melt-blown processing method, but the application fields of the nanometer-micrometer fiber non-woven fabric are mainly filtration separation, protective clothing, masks and the like, and the technical report of a melt-blown non-woven fabric patch in the application field of myocardial tissue repair is not seen at present.
Disclosure of Invention
The invention provides a multi-scale fiber negative Poisson ratio three-dimensional conductive melt-blown non-woven fabric myocardial patch.
The scheme adopted by the invention is as follows:
the non-woven fabric myocardial patch with nano-scale fibers and micro-scale fibers distributed in a specific mode is prepared by taking a polymer obtained by in-situ polymerization of thermoplastic biopolyurethane (TPU) and aniline monomer (ANI) as a raw material, wherein the conductivity of the non-woven fabric is 5 multiplied by 10 -5 -1.6×10 -3 S/cm, modulus of 200-500kPaThe hardness is 0.02-0.50MPa, the negative Poisson ratio under different strains of 10-20% is-1.1-0.5, and the simulation of myocardial tissue can be realized. The nano-micron fibers are arranged in a certain direction, and the fibers are arranged along the longitudinal direction and have anisotropy, and are matched with the laminated structures of the myocardial tissues in the long axis direction and the short axis direction, the ordered arrangement of the ECM and the anisotropic structure.
The preparation method of the multi-scale fiber negative Poisson ratio three-dimensional conductive melt-blown non-woven fabric myocardial patch comprises the following steps:
1) Carrying out in-situ polymerization reaction on thermoplastic biological polyurethane (TPU) and aniline monomer (ANI) to prepare a shape memory polymer PANI/TPU with a conductive function; the doping acid used is H 2 SO 4 The concentration is 0.5mol/L, the concentration of the oxidant ammonium sulfate is 0.2mol/L, the ratio of ANI to TPU is 1: and 2, reacting for 60min to obtain the elastic conductive polymer.
2) Regulating and controlling melt-blown technological parameters, and preparing melt-blown non-woven fabric by using a high-speed airflow melt-blowing method, wherein the width of an air gap is 0.1mm, the temperatures of three zones of a screw are respectively 170 ℃,230 ℃,260 ℃, the temperature of a die head is 240 ℃, a micro melt-blown tester with the diameter of a spinneret orifice of 0.02mm is adopted, the length-diameter ratio L/D of the screw is =28, the rotating speed of the screw is 60r/min, the temperature of hot air is 320 ℃, the pressure of hot air is 0.6MPa, and the receiving distance is 20 cm;
3) The non-woven fabric myocardial patch is formed by overlapping a plurality of fiber webs, each layer of fiber web is composed of fibers with mixed sizes of nanometer and micrometer, the diameter of the fibers is controlled to be 200nm-4 mu m, the overlapping thickness of the plurality of fiber webs is 200-400 mu m, all the fibers forming the non-woven fabric are arranged in the same direction, and the deviation is not more than 10 degrees.
The invention realizes the precise regulation and control of the fiber diameter by utilizing the high-speed airflow stretching; the orientation distribution of the fibers is regulated and controlled by increasing the distance of the receiving roller and the rotating speed parameters, and the air pressure process is added to prepare the nano-micron multi-scale mixed distribution melt-blown fibers. The nano-micron fiber melt-blown non-woven fabric is prepared by regulating and controlling the distance and the rotating speed of a receiving roller and air pressure parameters, so that the fibers are oriented and arranged in the longitudinal direction (MD) of the melt-blown non-woven fabric and have anisotropic structural characteristics.
According to the invention, by designing a material system, polyurethane and an aniline monomer (ANI) are utilized to carry out in-situ polymerization reaction to prepare a shape memory polymer with a conductive function, an electromechanical signal path of a myocardial infarction region can be formed, and by structural design, shape memory polymer fibers with a conductive function can be matched with an ordered arrangement structure of an extracellular matrix of a myocardial tissue and matched with the layered thickness of the myocardial tissue; can simulate the structure of the nano-micron fiber network of the extracellular matrix of the myocardial tissue. By designing the arrangement degree of the oriented fibers in the longitudinal direction of the melt-blown non-woven fabric, the arrangement states of the fibers in the longitudinal direction and the transverse direction are different, and the melt-blown non-woven fabric presents anisotropic structural characteristics. During stretching, under different strain conditions, the melt-blown fabric has different properties in the longitudinal direction and the transverse direction, shows anisotropic property change, and has a negative Poisson ratio of-1.1 to-0.5 under 10-20% strain. The mechanical property and the conductivity of the melt-blown non-woven fabric are anisotropic changes.
The properties of the non-woven fabric prepared by the invention can reach the theoretical range of myocardial tissues, the elastic deformation can better simulate the deformation requirements of myocardial contraction and relaxation, the modulus and the hardness of the non-woven fabric can provide good mechanical strength to play a role in supporting, and in addition, the non-woven fabric can be matched with the negative Poisson ratio deformation of myocardial contraction and relaxation through the regulation and control of the negative Poisson ratios of different strains.
The invention utilizes the shape memory polymer with the conductive function to promote the electric signal conduction of the myocardial infarction area and improve the conductivity, and the high-speed airflow drafting process of the melt-blown non-woven fabric preparation process is regulated and controlled, and the high-speed hot air is adopted to stretch the nascent fiber, so that the fiber diameter reaches the mixed range of nano-scale and micron-scale, the nano-micron fiber melt-blown non-woven fabric is prepared, the fiber network structure of the ECM in the myocardial infarction area is simulated, and the bionic microenvironment is reconstructed. The nano-micron fibers, directional arrangement, a multilayer fiber web superposed structure, longitudinal and transverse anisotropy ratio, good conductivity and stable signal conduction, elastic deformation, mechanical property and negative Poisson's ratio effect in the melt-blown non-woven fabric prepared by the invention can be matched with a layered structure of a myocardial tissue while simulating an ECM structure, the anisotropic structural characteristics of the myocardial tissue can be simulated, the deformation requirements of normal myocardial contraction and relaxation can be maintained, the mechanical strength of the myocardial tissue can be provided, the supporting effect can be achieved, the nano-micron fibers can be matched with the negative Poisson's ratio deformation of myocardial tissue contraction and relaxation under different strains, the electric signal conduction of a dead area can be promoted, and the myocardial function can be reconstructed.
Drawings
FIG. 1 is a schematic view of a three-dimensional negative Poisson's ratio deformed structural myocardial patch of the nano-micron melt-blown nonwoven fabric of example 1;
fig. 2 is a schematic diagram of a two-dimensional negative poisson's ratio deformed structure myocardial patch of the nano-micron meltblown nonwoven fabric of example 1.
Detailed Description
The invention is further described with reference to the following figures and specific examples.
Example 1
Carrying out in-situ polymerization reaction on thermoplastic biological polyurethane (TPU) and aniline monomer (ANI) to prepare a shape memory polymer PANI/TPU with a conductive function; the doping acid used is H 2 SO 4 The concentration is 0.5mol/L, the concentration of the ammonium sulfate as an oxidant is 0.2mol/L, and the ratio of ANI to TPU is 1: and 2, reacting for 60min to obtain the elastic conductive polymer.
Regulating and controlling melt-blown technological parameters, and utilizing a high-speed airflow melt-blowing method, wherein the width of an air gap is 0.1mm, the temperatures of three zones of a screw are respectively 170 ℃,230 ℃,260 ℃, the temperature of a die head is 240 ℃, a micro melt-blown tester with the diameter of a spinneret orifice of 0.02mm is adopted, the length-diameter ratio L/D of the screw is =28, the rotating speed of the screw is 60r/min, the temperature of hot air is 320 ℃, the pressure of hot air is 0.6MPa, and the receiving distance is 20cm, so that the melt-blown non-woven fabric is prepared by the following steps of.
The melt-blown nonwoven fabric has a fiber diameter of 200nm to 4 μm and a laminated thickness of 200 to 400 μm of a multi-layered web, wherein all fibers constituting the nonwoven fabric are arranged in a longitudinal direction orientation. Conductivity of 5X 10 -5 -1.6×10 -3 S/cm, modulus of 200-500kPa, hardness of 0.02-0.50MPa, negative Poisson' S ratio of-1.1 to-0.5 under different strains of 10-20%, and can simulate myocardial tissue and anisotropic deformation.
Example 2
Thermoplastic biopolyurethane TPCarrying out in-situ polymerization reaction on the U and an aniline monomer ANI to prepare a shape memory polymer PANI/TPU with a conductive function; the doping acid used is H 2 SO 4 The concentration is 0.5mol/L, the concentration of the oxidant ammonium sulfate is 0.2mol/L, the ratio of ANI to TPU is 1: and 2, reacting for 60min to obtain the elastic conductive polymer.
The melt-blown process parameters are regulated, and when high-speed airflow stretching is not adopted, the fiber diameter of the obtained melt-blown fabric is far larger than 4 mu m, the superfine fiber network structural characteristics of the myocardial tissue extracellular matrix cannot be well simulated, and the function reconstruction effect of myocardial infarction treatment cannot be effectively realized.
Example 3
Carrying out in-situ polymerization reaction on thermoplastic biological polyurethane (TPU) and aniline monomer (ANI) to prepare a shape memory polymer PANI/TPU with a conductive function; the doping acid used is H 2 SO 4 The concentration is 0.5mol/L, the concentration of the oxidant ammonium sulfate is 0.2mol/L, the ratio of ANI to TPU is 1: and 2, reacting for 60min to obtain the elastic conductive polymer.
The melt-blown process parameters are regulated, when the rotating speed of the receiving roller is less than 60rpm, the arrangement state of the fibers in the longitudinal direction is random, the orientation arrangement cannot be well realized, and at the moment, the melt-blown fabric is close to the isotropic performance change, does not have the anisotropic requirement and does not meet the deformation requirement of the myocardial patch.
Example 4
Adopting thermoplastic biological polyurethane (TPU), regulating and controlling melt-blowing technological parameters, and utilizing a high-speed air flow melt-blowing method, wherein the width of an air gap is 0.1mm, the temperatures of three zones of a screw are respectively 170 ℃,230 ℃,260 ℃, the temperature of a die head is 240 ℃, a micro melt-blowing tester with the diameter of a spinneret orifice of 0.02mm is adopted, the length-diameter ratio L/D of the screw is =28, the rotating speed of the screw is 60r/min, the temperature of hot air is 320 ℃, the pressure of hot air is 0.6MPa, and the receiving distance of the melt-blown non-woven fabric is 20 cm. The melt-blown non-woven fabric prepared by the embodiment has good elastic deformation, but does not have conductivity, cannot achieve the effect of signal conduction, and cannot achieve the purpose of myocardial function reconstruction.
Example 5
When the aniline monomer is used for carrying out the experiment of melt-blowing processing, the melt-blowing processing of single components cannot be carried out due to the infusible characteristic of the conductive polymer, so that a melt-blown non-woven fabric cannot be formed, and the myocardial tissue cannot be simulated.
Claims (3)
1. The multi-scale fiber negative Poisson ratio three-dimensional conductive melt-blown non-woven fabric myocardial patch is characterized in that a polymer obtained by in-situ polymerization of Thermoplastic Polyurethane (TPU) and aniline monomer (ANI) is used as a raw material to prepare the non-woven fabric myocardial patch with nano-scale fibers and micron-scale fibers distributed in a longitudinal orientation mode; the non-woven fabric is obtained by superposing a plurality of fiber webs, each layer of the fiber web is composed of fibers with mixed nano-micron dimensions, the fiber diameter distribution is 200nm-4 mu m, and the preparation method of the myocardial patch comprises the following steps:
1) Carrying out in-situ polymerization reaction on thermoplastic biological polyurethane (TPU) and aniline monomer (ANI) to prepare a shape memory polymer PANI/TPU with a conductive function; in the in-situ polymerization reaction: h 2 SO 4 The concentration is 0.2-0.5mol/L, the concentration of the oxidant ammonium sulfate is 0.2-0.5mol/L, the ratio of ANI to TPU is 1:2-1:4, reacting for 10-60min to obtain the elastic conductive polymer;
2) Processing the elastic conductive polymer prepared in the step 1) by adopting melt-blowing equipment to prepare the non-woven fabric myocardial patch in nano-micron multi-scale mixed distribution, wherein the parameters of the melt-blowing equipment are as follows: the width of the air gap is 0.1-0.4mm, the temperatures of the three zones of the screw are 160-170 ℃,230-240 ℃,260-270 ℃, the temperature of the die head is 240-270 ℃, the distance of the receiving roller is 20-60cm, the rotating speed of the receiving roller is 60-100rpm, and the high-speed air pressure is 0.4-0.6MPa respectively.
2. The multi-scale fiber negative poisson's ratio three-dimensional conductive melt-blown non-woven fabric myocardial patch as claimed in claim 1, wherein the fiber diameter distribution in the non-woven fabric is 200nm-4 μm, the laminated thickness of the multiple layers of fiber webs is 200-400 μm, all fibers forming the non-woven fabric are arranged in the same direction, and the arrangement angle is 80-90 degrees.
3. According to the claimSolving 1 the multi-scale fiber negative Poisson ratio three-dimensional conductive melt-blown non-woven fabric myocardial patch, which is characterized in that the non-woven fabric has the conductivity of 5 multiplied by 10 -5 -1.6×10 -3 S/cm, modulus of 200-500kPa, hardness of 0.02-0.50MPa, and negative Poisson' S ratio of-1.1 to-0.5 under different strains of 10-20%.
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| CN1433443A (en) * | 1999-12-07 | 2003-07-30 | 威廉马歇莱思大学 | Oriented nanofibers embedded in polymer matrix |
| CN109457309A (en) * | 2018-09-10 | 2019-03-12 | 中国科学院宁波材料技术与工程研究所 | A kind of polyglycolic acid oriented nanofibers beam and preparation method thereof |
| CN111648025A (en) * | 2020-03-23 | 2020-09-11 | 东华大学 | Micro-nano fiber warming flocculus with longitudinal variable density structure and preparation method thereof |
| CN112089893A (en) * | 2020-08-07 | 2020-12-18 | 浙江理工大学 | Preparation method of high-breathability elastic nanofiber heart patch with controllable conductivity and viscosity |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1433443A (en) * | 1999-12-07 | 2003-07-30 | 威廉马歇莱思大学 | Oriented nanofibers embedded in polymer matrix |
| CN109457309A (en) * | 2018-09-10 | 2019-03-12 | 中国科学院宁波材料技术与工程研究所 | A kind of polyglycolic acid oriented nanofibers beam and preparation method thereof |
| CN111648025A (en) * | 2020-03-23 | 2020-09-11 | 东华大学 | Micro-nano fiber warming flocculus with longitudinal variable density structure and preparation method thereof |
| CN112089893A (en) * | 2020-08-07 | 2020-12-18 | 浙江理工大学 | Preparation method of high-breathability elastic nanofiber heart patch with controllable conductivity and viscosity |
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