CN113558823A - Valve support of intervention treatment reaches valve replacement device including it - Google Patents
Valve support of intervention treatment reaches valve replacement device including it Download PDFInfo
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- CN113558823A CN113558823A CN202110839320.6A CN202110839320A CN113558823A CN 113558823 A CN113558823 A CN 113558823A CN 202110839320 A CN202110839320 A CN 202110839320A CN 113558823 A CN113558823 A CN 113558823A
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- 229910052751 metal Inorganic materials 0.000 claims abstract description 89
- 239000002184 metal Substances 0.000 claims abstract description 89
- 210000004115 mitral valve Anatomy 0.000 claims abstract description 56
- 238000004873 anchoring Methods 0.000 claims abstract description 19
- 230000008093 supporting effect Effects 0.000 claims abstract description 10
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 10
- 230000000903 blocking effect Effects 0.000 claims description 15
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 12
- 239000004744 fabric Substances 0.000 claims description 10
- 210000005240 left ventricle Anatomy 0.000 claims description 10
- 238000002513 implantation Methods 0.000 claims description 7
- 210000005246 left atrium Anatomy 0.000 claims description 7
- 229910052697 platinum Inorganic materials 0.000 claims description 6
- 229910001285 shape-memory alloy Inorganic materials 0.000 claims description 6
- 229910000566 Platinum-iridium alloy Inorganic materials 0.000 claims description 3
- 229920004933 Terylene® Polymers 0.000 claims description 3
- 229910003460 diamond Inorganic materials 0.000 claims description 3
- 239000010432 diamond Substances 0.000 claims description 3
- 229910001000 nickel titanium Inorganic materials 0.000 claims description 3
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical class [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 claims description 3
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
Abstract
The invention provides an interventional therapy valve stent and a valve replacement device comprising the same, wherein the valve stent comprises a straight cylindrical metal frame with a D-shaped section, a support ring is arranged at the edge of one end of the metal frame along the circumferential outer edge, and at least one inverted hook type anchor is obliquely arranged on the outer circumferential surface and the inner side surface of the metal frame respectively; the other end edge of the metal frame is provided with at least one edge anchor which extends outwards from the edge. The metal frame is designed into a D-shaped section and is provided with the inverted hook type anchoring structure, so that the valve stent is not easy to shift after being released, and positioning and supporting can be provided for subsequent transcatheter mitral valve replacement, and a better treatment effect can be achieved.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and relates to a valve stent for interventional therapy and a valve replacement device comprising the same.
Background
Mitral Regurgitation (MR) is one of the most common valvular lesions, and epidemiological research data show that MR suffers from 10% of the population over 75 years of age, significantly exceeding aortic valvular lesions. As the population ages, the progression of the lesion increases, mitral regurgitation will also result in a heavy medical burden. Mitral valve repair or replacement is the gold standard for MR treatment, but studies have shown that up to half of the severely symptomatic MR patients have not selected surgical treatment for reasons largely related to their surgical risk. This large proportion of patients with poor surgical tolerance urgently need a less invasive treatment as an alternative, and interventional mitral valve treatment techniques, which are divided into two branches of interventional repair and replacement, have emerged.
(1) Transcatheter mitral valve repair technique
Over the past decade, several transcatheter mitral valve repair techniques derived from different surgical approaches have emerged and are used to treat patients at high surgical risk or who are inoperable. Transcatheter mitral valve repair "kits" are expanding rapidly, and 5 devices approved for clinical use have been investigated, including edge-to-edge leaflet repair, interventional artificial chordae tendineae repair, transcoronary sinus annuloplasty devices, interventional mitral annuloplasty rings, and mitral annulus folding techniques.
(2) Transcatheter mitral valve replacement
Although current research advances more slowly than interventional repair techniques, Transcatheter Mitral Valve Replacement (TMVR) theoretically has inherent advantages over transcatheter repair. Given the complexity and heterogeneity of mitral valve disease, there is a significant challenge in developing a transcatheter mitral valve repair device that is suitable for treating patients with all types of mitral valve lesion anatomy and levels of risk. TMVR offers a universal concept for treatment of mitral valve disease (i.e., no matter what the pathological changes of the mitral valve are), while MR treatment is more reliably predictable (biological valve durability has been well proven), and is much less invasive than traditional surgical approaches.
In recent years, interventional therapy for transcatheter heart valve disease mainly based on TMVR has become the most important topic of structural heart disease, and is called the fourth revolution of interventional cardiology. With the continuous improvement of valve design and the update of a technical theory system, the complications related to paravalvular leak, conduction block, cerebral infarction and the like are remarkably reduced, and the intervention treatment of the mitral valve and the tricuspid valve which is regarded as a daunting way in the past also starts to break ice, so that new progress is continuously made.
CN112566590A a prosthetic mitral valve comprising an anchor assembly, a strut frame, and a replacement leaflet secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and atrial anchor are configured to expand radially relative to the central portion. The annular strut frame is radially mounted within and attached to the anchor assembly. The central portion is configured to align with a native valve orifice, the ventricular anchor and the atrial anchor configured to compress native heart tissue therebetween.
The CN111000663A prosthetic heart valve includes a flexible anchoring member at least partially surrounding and connected to an inner valve support. The device may also include a prosthetic valve attached to, mounted within, or otherwise carried by the valve support. The valve support includes a plurality of posts circumferentially connected by a plurality of rods, wherein the posts extend in an axial direction generally parallel to the longitudinal axis, and the rods extend circumferentially around and transverse to the longitudinal axis. These posts extend the entire longitudinal height of the valve support. The device also includes one or more sealing members and tissue engaging components, such as spikes.
CN110090094A prosthetic valve and method of making a prosthetic valve. The present invention relates to a prosthetic valve comprising a leaflet assembly having at least one leaflet attached to a support member, the leaflet having a free edge movable between a first position and a second position, wherein in the first position the free edge flexes away from a closure surface to allow bodily fluids to flow through the valve; in a second position, the free edge abuts the closure surface to close the valve, and wherein the leaflets are capable of forming an engagement height of greater than 0.1mm along the length of the free edge in the absence of a pulsatile load on the valve.
The interventional mitral valve products currently used by TMVR are usually single-valve interventional treatments, mainly composed of memory alloy frames with biological tissue leaflets attached and fabrics partially coated on metal, and because the mitral valve is large in size, the corresponding interventional mitral valve products are also large in size. The metal frame adopted by the product is very light and thin, but the metal frame has larger size, so that the metal frame bears more stress, has insufficient durability and is easy to break or break down. In addition, the intervention mitral valve has a large size, so the intervention mitral valve has a large depth into the left ventricle part and is easy to be wound with chordae tendineae, thereby affecting the normal work and even causing the failure.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide an interventional therapy valve stent and a valve replacement device comprising the same.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the invention provides an interventional therapy valve stent, which comprises a straight cylindrical metal frame with a D-shaped cross section, wherein a support ring is arranged at the edge of one end of the metal frame along the circumferential outer edge, and at least one inverted hook type anchor is obliquely arranged on the outer circumferential surface and the inner side surface of the metal frame respectively; the edge of the other end of the metal frame is provided with at least one edge anchor, and the edge anchor extends outwards from the edge;
the valve stent has a compressed state and an expanded state, the valve stent is implanted into the body by means of the delivery device under the compressed state, and the implantation target position is switched into the expanded state so as to be fixed at the valve; in the deployed configuration, the support ring is positioned in the left atrium and the metal frame is positioned in the left ventricle, and the valve stent is secured by the barb-type anchor and the edge anchor.
The invention provides a valve stent for interventional therapy, wherein a metal frame can expand or contract along the radial direction, is in a contracted state before being implanted into a human body, is released at a specific position after being implanted into the human body, and is expanded to enable the metal frame to abut against the ventricular wall, so that the valve stent is fixed at the position of a mitral valve; according to the invention, the metal frame is designed into a D-shaped section, and is matched with the physiological structure of the natural valve, so that the compression of the valve stent on the outflow tract of the heart caused by the unmatched shape can be effectively avoided, and further other complications of a patient can be caused; in addition, the periphery of the metal frame is obliquely provided with the inverted hook type anchoring piece, the edge anchoring piece is arranged at one end edge of the metal frame, and after the valve support is implanted, the inverted hook type anchoring piece and the edge anchoring piece can penetrate into tissues around the valve to further play an anchoring role, so that the valve support is not easy to shift after being released, the outer wall of the valve support is tightly attached to a blood flow channel after being released, the valve support is matched with surrounding tissues to form a blocking structure, and the valve support is favorable for avoiding perivalvular leakage.
As a preferable technical scheme of the invention, the metal frame is surrounded by a curved straight wall and a plane straight wall to form a D-shaped straight cylindrical structure.
The invention designs the metal frame into a D-shaped section which is matched with the physiological structure of the natural valve, in particular to the shape of the containing space enclosed by the wall of the original body of the original mitral valve, thus the invention has the advantages that: (1) when in use, the metal framework can be effectively prevented from pressing the outflow tract of the heart due to the unmatched shape, so that other complications of a patient can be avoided; (2) the shape phase-match of metal frame and mitral valve accommodation space can make the metal frame outer wall closely laminate blood flow channel, and the tissue cooperation is convenient for the membrane to form block structure around with, is favorable to avoiding the valve to leak all around.
As a preferable technical scheme of the invention, the support ring is surrounded by the semi-annular plate and the straight plate to form a D-shaped annular structure.
The curved straight wall and the semi-annular plate are mutually vertical and are in edge butt joint.
The plane straight wall and the straight plate are mutually vertical and the edges are butted.
In a preferred embodiment of the present invention, the metal frame is made of a memory alloy, preferably a nickel-titanium alloy.
The size of the metal frame can be adjusted at will by adopting the memory alloy material, the metal frame is always in the contraction device in the implantation process of the valve stent, and when the valve stent is released after reaching the target position, the valve stent can be quickly expanded from the contraction state to abut against the ventricular wall.
As a preferable technical scheme of the invention, the metal frame is of a grid structure.
Preferably, the metal frame is a diamond grid structure.
The grid shape of the metal frame is designed into a diamond shape, so that the strength and the supporting force of the valve stent are improved, and the valve stent is prevented from being broken due to insufficient strength and supporting force.
As a preferred embodiment of the present invention, the valve stent further comprises a fabric layer covering the metal frame.
Preferably, the fabric layer is made of terylene.
As a preferred embodiment of the present invention, the fabric layer is provided with at least one development point.
Preferably, the developing point is made of one or a combination of at least two of platinum-iridium alloy, platinum and platinum.
According to the invention, the developing points are arranged on the metal frame, so that the position of the valve support can be dynamically monitored through the developing points in the releasing process, and the purposes of accurate positioning and releasing are achieved.
In a preferred embodiment of the present invention, the barb type anchor and the edge anchor are independently selected from a spike-like structure or a U-shaped structure.
It should be noted that "independently selected" in the present invention means that the lengths of the barb-type anchor and the edge anchor may be both spike-shaped structures, may also be both U-shaped structures, and may also be one spike-shaped structure and the other U-shaped structure.
Preferably, the barb-type anchor and the edge anchor are disposed obliquely downward in a left ventricular-to-left atrial direction.
Preferably, the lengths of the barb anchor and the edge anchor are each independently selected from 1mm to 5mm, and may be, for example, 1.0mm, 1.5mm, 2.0mm, 2.5mm, 3.0mm, 3.5mm, 4.0mm, 4.5mm, or 5.0mm, but are not limited to the values recited, and other values not recited within this range are equally applicable.
The term "independently selected" as used herein means that the lengths of the barb anchor and the edge anchor may be equal to or different from each other, as long as the lengths are in the range of 1mm to 5 mm.
In a second aspect, the present invention provides an interventional valve replacement device, comprising the valve stent of the first aspect, wherein at least two interventional mitral valves are arranged in a metal frame of the valve stent.
In the present invention, instead of implanting a single larger interventional mitral valve, two irregularly shaped interventional mitral valves of smaller size are implanted sequentially via a catheter, and because of their smaller size, the metal frame can be made stronger than a single interventional mitral valve and less enter the left ventricle portion than a single interventional mitral valve. The sum of the opening areas of the two smaller petals can meet the requirement of a human body, and a better treatment effect can be achieved.
As a preferable technical scheme of the invention, an elastic blocking piece is further arranged in the metal frame of the valve support, the blocking piece is positioned in a gap space formed between the curved straight wall and the valve, and the valve is fixed in the valve support through the external support effect of the blocking piece.
Preferably, the plugging piece is of a straight cylindrical metal framework structure.
Preferably, the plugging piece is as high as the metal frame.
Preferably, the plugging piece is arranged close to the inner side of the curved straight wall.
It should be noted that the blocking piece provided by the invention is mainly used for fixing the valve, after the valve stent is implanted into the body, the small-sized interventional mitral valve is transferred to the valve stent through the catheter, and because the size of the interventional mitral valve is smaller than that of the valve stent, a gap space still exists between the interventional mitral valve and the valve stent, in order to better fix the interventional mitral valve in the valve stent, the blocking piece which can be deformed in a telescopic manner is arranged in the gap space, and the plugging piece can adapt to the interventional mitral valves with different sizes through the telescopic deformation capability of the blocking piece. After implantation, one side surface of the plugging piece props against the inner side surface of the curved straight wall, the other side surface of the plugging piece respectively plugs the peripheral surface of each interventional mitral valve, and the gap between the valve support and the interventional mitral valve is filled up and props against the interventional mitral valve under the action of the deformed outer support of the plugging piece, so that the interventional mitral valve cannot fall off.
Illustratively, the present invention provides a method for implanting a valve stent, comprising the steps of:
the valve stent is brought into a patient body through the conveying device, when the valve stent reaches a target position, the valve stent is released, the valve stent can be quickly unfolded from a contraction state, the supporting section is positioned in the left atrium, the metal frame is positioned in the left ventricle, when the heart relaxes, the mitral valve can clamp the supporting ring to prevent the valve stent from sliding into the ventricle, and when the heart contracts, the valve stent can be prevented from moving to the atrium due to the action of the barbs, so that the valve stent provided by the invention can be more effectively prevented from shifting under the pressure and the scouring of blood flow after the valve stent is released, the service life of the valve stent after being released is prolonged, and the damage of the valve stent to surrounding tissues is reduced.
Compared with the prior art, the invention has the beneficial effects that:
the invention provides a valve stent for interventional therapy, wherein a metal frame can expand or contract along the radial direction, is in a contracted state before being implanted into a human body, is released at a specific position after being implanted into the human body, and is expanded to enable the metal frame to abut against the ventricular wall, so that the valve stent is fixed at the position of a mitral valve; according to the invention, the metal frame is designed into a D-shaped section, and is matched with the physiological structure of the natural valve, so that the compression of the valve stent on the outflow tract of the heart caused by the unmatched shape can be effectively avoided, and further other complications of a patient can be caused; in addition, the periphery of the metal frame is obliquely provided with the inverted hook type anchoring piece, the edge anchoring piece is arranged at one end edge of the metal frame, and after the valve support is implanted, the inverted hook type anchoring piece and the edge anchoring piece can penetrate into tissues around the valve to further play an anchoring role, so that the valve support is not easy to shift after being released, the outer wall of the valve support is tightly attached to a blood flow channel after being released, the valve support is matched with surrounding tissues to form a blocking structure, and the valve support is favorable for avoiding perivalvular leakage.
Drawings
FIG. 1 is a schematic structural view of a valve stent according to an embodiment of the present invention;
FIG. 2 is a top view of a valve stent according to an embodiment of the present invention;
FIG. 3 is a side view of a valve stent provided in accordance with an embodiment of the present invention;
wherein, 1-a metal frame; 2-a support ring; 3-edge anchor; 4-plugging piece; 5-inverted hook type anchor.
Detailed Description
It is to be understood that in the description of the present invention, the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be taken as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.
It should be noted that, in the description of the present invention, unless otherwise explicitly specified or limited, the terms "disposed," "connected" and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.
The technical scheme of the invention is further explained by the specific implementation mode in combination with the attached drawings.
In one embodiment, the present invention provides an interventional therapy valve stent, as shown in fig. 1, 2 and 3, the valve stent comprises a straight cylindrical metal frame 1 with a D-shaped cross section, wherein a support ring 2 is arranged at one end edge of the metal frame 1 along the circumferential outer edge, and at least one inverted hook type anchor 5 is obliquely arranged on the outer circumferential surface and the inner side surface of the metal frame 1 respectively; the other end edge of the metal frame 1 is provided with at least one edge anchor 3, said edge anchor 3 projecting outwards from the edge.
The valve stent has a compressed form and an expanded form, the valve stent is implanted into the body by means of the delivery device in the compressed form, and the implantation target position is switched to the expanded form so as to be fixed at the valve; in the deployed configuration, the support ring 2 is in the left atrium and the metal frame 1 is in the left ventricle, and the valve stent is secured by means of the barb anchors 5 and the edge anchors 3.
The invention provides a valve stent for interventional therapy, wherein a metal frame 1 can expand or contract along the radial direction, before being implanted into a human body, the metal frame 1 is in a contracted state and is released at a specific position after being implanted into the human body, and the metal frame 1 is expanded to enable the metal frame 1 to prop against the wall of a heart chamber, so that the valve stent is fixed at the position of a mitral valve; according to the invention, the metal frame 1 is designed into a D-shaped section and is matched with the physiological structure of a natural valve, so that the compression of the valve stent on the outflow tract of the heart caused by the unmatched shape can be effectively avoided, and further other complications of a patient can be caused; in addition, the periphery of the metal frame 1 is obliquely provided with the inverted hook type anchoring piece 5, the edge anchoring piece 3 is arranged at one end edge of the metal frame 1, after the valve support is implanted, the inverted hook type anchoring piece 5 and the edge anchoring piece 3 can penetrate into tissues around a valve to further play an anchoring role, so that the valve support is not easy to shift after being released, the outer wall of the valve support is tightly attached to a blood flow channel after being released, the valve support is matched with surrounding tissues to form a blocking structure, and the valve support is favorable for avoiding perivalvular leakage.
Further, the metal frame 1 is enclosed by a curved straight wall and a flat straight wall to form a D-shaped straight cylindrical structure.
The invention designs the metal frame 1 into a D-shaped section which is matched with the physiological structure of the natural valve, in particular to the shape of the containing space enclosed by the wall of the original body of the original mitral valve, thus the invention has the advantages that: (1) when in use, the metal frame 1 can effectively avoid the oppression of the outflow tract of the heart caused by the mismatching of the shapes, thereby causing other complications of the patient; (2) the shape phase-match of metal frame 1 and mitral valve accommodation space can make 1 outer wall of metal frame closely laminate blood flow channel, and the tissue cooperation is convenient for form the block structure around with, is favorable to avoiding the valve to leak all around.
Further, the support ring 2 is enclosed by a half-ring plate and a straight plate to form a D-ring structure. The curved straight wall and the semi-annular plate are mutually perpendicular and the edges are butted, and the plane straight wall and the straight plate are mutually perpendicular and the edges are butted.
Further, the material of the metal frame 1 is a memory alloy, preferably a nickel titanium alloy.
According to the invention, the size of the metal frame 1 can be adjusted at will by adopting the memory alloy material, the metal frame 1 is always in the contraction device in the implantation process of the valve stent, and when the valve stent is released after reaching the target position, the valve stent can be quickly unfolded from the contraction state to abut against the ventricular wall.
Further, the metal frame 1 is of a grid structure; further, the metal frame 1 has a diamond-shaped lattice structure.
The grid shape of the metal frame 1 is designed to be diamond-shaped, so that the strength and the supporting force of the valve stent are improved, and the valve stent is prevented from being broken due to insufficient strength and supporting force.
Further, the valve stent also comprises a fabric layer wrapping the metal frame 1; furthermore, the fabric layer is made of terylene.
Further, at least one developing point is arranged on the fabric layer; specifically, the material of the developing point is one or a combination of at least two of platinum-iridium alloy, platinum and platinum.
According to the invention, the developing points are arranged on the metal frame 1, so that the position of the valve support can be dynamically monitored through the developing points in the releasing process, and the purposes of accurate positioning and releasing are achieved.
Further, the barb anchor 5 and the edge anchor 3 are each independently selected from a spike-like structure or a U-shaped structure.
It should be noted that "independently selected" in the present invention means that the lengths of the barb-type anchor 5 and the edge anchor may be both spike-shaped structures, may also be both U-shaped structures, and may also be one spike-shaped structure and the other U-shaped structure.
Further, the barb type anchor 5 and the edge anchor 3 are disposed obliquely downward in the left ventricle to left atrium direction.
Further, the lengths of the barb type anchor 5 and the edge anchor 3 are each independently selected from 1mm to 5 mm.
The phrase "independently selected from" as used herein means that the lengths of the barb type anchor 5 and the edge anchor 3 may be equal to or different from each other, as long as the lengths are in the range of 1mm to 5 mm.
In another embodiment, the present invention provides an interventional valve replacement device comprising the valve stent of the above embodiment, wherein at least two interventional mitral valves are disposed within the metal frame 1 of the valve stent.
In the present invention, instead of implanting a single larger interventional mitral valve, two irregularly shaped interventional mitral valves of smaller size are implanted sequentially via a catheter, and because of their smaller size, the metal frame 1 can be made stronger than a single interventional mitral valve and less enter the left ventricle portion than a single interventional mitral valve. The sum of the opening areas of the two smaller petals can meet the requirement of a human body, and a better treatment effect can be achieved.
Further, still set up elastic shutoff piece 4 in valve support's the metal framework 1, shutoff piece 4 is located the gap space that forms between curved surface straight wall and the valve, and the outer effect of propping through shutoff piece 4 is fixed in valve support with the valve.
Specifically, the plugging piece 4 is of a straight cylindrical metal framework structure, the height of the plugging piece 4 is equal to that of the metal frame 1, and the plugging piece 4 is arranged close to the inner side of the curved straight wall.
It should be noted that the blocking member 4 provided by the present invention is mainly used for fixing a valve, after a valve stent is implanted into a body, a small-sized interventional mitral valve is transferred to the valve stent through a catheter, and because the size of the interventional mitral valve is smaller than that of the valve stent, a gap space still exists between the interventional mitral valve and the valve stent, in order to better fix the interventional mitral valve in the valve stent, the present invention arranges the blocking member 4 capable of being deformed in a telescopic manner in the gap space, and the present invention can adapt to interventional mitral valves of different sizes through the capability of the blocking member capable of being deformed in a telescopic manner. After implantation, one side surface of the plugging piece 4 props against the inner side surface of the curved straight wall, the other side surface of the plugging piece 4 respectively plugs the peripheral surface of each interventional mitral valve, and the gap between the valve support and the interventional mitral valve is filled up and props against the interventional mitral valve under the action of the deformed outer support of the plugging piece, so that the interventional mitral valve cannot fall off.
In another embodiment, the present invention provides a method for implanting a valve stent, comprising the steps of:
the valve stent is brought into a patient body through the conveying device, when the valve stent reaches a target position, the valve stent is released, the valve stent can be quickly unfolded from a contraction state, the supporting section is positioned in the left atrium, the metal frame 1 is positioned in the left ventricle, when the heart relaxes, the mitral valve can clamp the supporting ring 2 to prevent the valve stent from sliding into the ventricle, and when the heart contracts, the valve stent can be prevented from moving towards the ventricle due to the effect of the barbs, so that the valve stent provided by the invention can be more effectively prevented from shifting under the pressure and the scouring of blood flow after the valve stent is released, the service life of the valve stent after being released is prolonged, and the damage of the valve stent to surrounding tissues is reduced.
The applicant declares that the above description is only a specific embodiment of the present invention, but the scope of the present invention is not limited thereto, and it should be understood by those skilled in the art that any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are within the scope and disclosure of the present invention.
Claims (10)
1. The valve stent for interventional therapy is characterized by comprising a straight cylindrical metal frame with a D-shaped section, wherein a support ring is arranged at the edge of one end of the metal frame along the circumferential outer edge, and at least one inverted hook type anchor is obliquely arranged on the outer circumferential surface and the inner side surface of the metal frame respectively; the edge of the other end of the metal frame is provided with at least one edge anchor, and the edge anchor extends outwards from the edge;
the valve stent has a compressed state and an expanded state, the valve stent is implanted into the body by means of the delivery device under the compressed state, and the implantation target position is switched into the expanded state so as to be fixed at the valve; in the deployed configuration, the support ring is positioned in the left atrium and the metal frame is positioned in the left ventricle, and the valve stent is secured by the barb-type anchor and the edge anchor.
2. The valve stent of claim 1, wherein the metal frame is enclosed by a curved straight wall and a flat straight wall to form a D-shaped straight cylindrical structure.
3. The valve holder of claim 2, wherein the support ring is defined by semi-annular plates and straight plates to form a D-shaped ring structure;
the curved straight wall and the semi-annular plate are mutually vertical and are in edge butt joint;
the plane straight wall and the straight plate are mutually vertical and the edges are butted.
4. The valve stent of any one of claims 1-3, wherein the metal frame is made of a memory alloy, preferably a nickel-titanium alloy.
5. The valve stent of any one of claims 1-4, wherein the metal frame is a lattice structure;
preferably, the metal frame is a diamond grid structure.
6. The valve stent of any one of claims 1-5, wherein the valve stent further comprises a fabric layer surrounding the metal frame;
preferably, the fabric layer is made of terylene.
7. The valve stent of claim 6, wherein the fabric layer is provided with at least one visualization point;
preferably, the developing point is made of one or a combination of at least two of platinum-iridium alloy, platinum and platinum.
8. The valve stent of any one of claims 1-7, wherein the barb anchors and the edge anchors are each independently selected from spike-like structures or U-shaped structures;
the barb type anchoring piece and the edge anchoring piece are arranged obliquely downwards along the direction from the left ventricle to the left atrium;
preferably, the lengths of the barb type anchor and the edge anchor are respectively and independently selected from 1 mm-5 mm.
9. An interventional valve replacement device comprising a valve stent according to any one of claims 1-8 having at least two interventional mitral valves disposed within a metal frame of the stent.
10. The valve replacement device of claim 9, wherein an elastic blocking member is further disposed in the metal frame of the valve holder, the blocking member is located in a gap space formed between the curved straight wall and the valve, and the valve is fixed in the valve holder by an external supporting action of the blocking member;
preferably, the plugging piece is of a straight cylindrical metal framework structure;
preferably, the plugging piece is as high as the metal frame;
preferably, the plugging piece is arranged close to the inner side of the curved straight wall.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110839320.6A CN113558823A (en) | 2021-07-23 | 2021-07-23 | Valve support of intervention treatment reaches valve replacement device including it |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110839320.6A CN113558823A (en) | 2021-07-23 | 2021-07-23 | Valve support of intervention treatment reaches valve replacement device including it |
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| CN113558823A true CN113558823A (en) | 2021-10-29 |
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| CN202110839320.6A Pending CN113558823A (en) | 2021-07-23 | 2021-07-23 | Valve support of intervention treatment reaches valve replacement device including it |
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| US6371983B1 (en) * | 1999-10-04 | 2002-04-16 | Ernest Lane | Bioprosthetic heart valve |
| US20080154359A1 (en) * | 2001-11-01 | 2008-06-26 | Salgo Ivan S | Non-planar cardiac vascular support prosthesis |
| US20160235529A1 (en) * | 2013-10-05 | 2016-08-18 | Sino Medical Sciences Technology, Inc. | Device and Method for Mitral Valve Regurgitation Treatment |
| US20160278916A1 (en) * | 2008-04-08 | 2016-09-29 | Medtronic, Inc. | Multiple Orifice Implantable Heart Valve and Methods of Implantation |
| CN112022441A (en) * | 2020-09-15 | 2020-12-04 | 王洪志 | Heart valve and valve conveying device |
| CN212662031U (en) * | 2020-09-15 | 2021-03-09 | 杭州德晋医疗科技有限公司 | Artificial heart valve stent, artificial heart valve and artificial heart valve replacement system |
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2021
- 2021-07-23 CN CN202110839320.6A patent/CN113558823A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6371983B1 (en) * | 1999-10-04 | 2002-04-16 | Ernest Lane | Bioprosthetic heart valve |
| US20080154359A1 (en) * | 2001-11-01 | 2008-06-26 | Salgo Ivan S | Non-planar cardiac vascular support prosthesis |
| US20160278916A1 (en) * | 2008-04-08 | 2016-09-29 | Medtronic, Inc. | Multiple Orifice Implantable Heart Valve and Methods of Implantation |
| US20160235529A1 (en) * | 2013-10-05 | 2016-08-18 | Sino Medical Sciences Technology, Inc. | Device and Method for Mitral Valve Regurgitation Treatment |
| CN112022441A (en) * | 2020-09-15 | 2020-12-04 | 王洪志 | Heart valve and valve conveying device |
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