CN113520349A - Physiological parameter measuring device, terminal and method - Google Patents

Physiological parameter measuring device, terminal and method Download PDF

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CN113520349A
CN113520349A CN202110625605.XA CN202110625605A CN113520349A CN 113520349 A CN113520349 A CN 113520349A CN 202110625605 A CN202110625605 A CN 202110625605A CN 113520349 A CN113520349 A CN 113520349A
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polarization mode
physiological parameter
light
polarization
mode
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周勇
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Shenzhen Maidu Technology Co ltd
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Publication of CN113520349A publication Critical patent/CN113520349A/en
Priority to PCT/CN2021/136061 priority patent/WO2022252535A1/en
Priority to CN202180006565.9A priority patent/CN114786577A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02416Detecting, measuring or recording pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
    • AHUMAN NECESSITIES
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    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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    • A61B5/026Measuring blood flow
    • A61B5/0261Measuring blood flow using optical means, e.g. infrared light
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    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
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    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
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    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552Details of sensors specially adapted therefor

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Abstract

The application relates to a physiological parameter measuring device, a terminal and a method. The physiological parameter measuring device includes: an emission module configured to emit light of one or more wavelengths, the light emitted by the emission module satisfying a first polarization mode and illuminating a target under test; a detection module configured to filter light reflected by the target under test, the light filtered by the detection module satisfying a second polarization mode; and a processor. The processor is configured to determine a difference of the second polarization mode with respect to the first polarization mode according to the physiological parameter to be measured of the object to be measured and the wavelength of the light emitted by the emission module to optimize a measurement signal based on the light filtered by the detection module and used to determine the physiological parameter to be measured. In this way, the influence of the reflected light at a specific depth of the skin on the measurement signal is selectively enhanced by the polarization mode-based filtering manner, so that the physiological parameter related to the specific depth can be obtained through the measurement signal.

Description

Physiological parameter measuring device, terminal and method
Technical Field
The application relates to the technical field of intelligent terminals, in particular to a physiological parameter measuring device, a physiological parameter measuring terminal and a physiological parameter measuring method.
Background
With the development of intelligent terminal technology, intelligent wearable equipment has gained huge application in monitoring human relevant physiological parameters. Wearable equipment of intelligence has added the function of measuring various physiological parameters especially blood relevant parameter like intelligent wrist-watch, intelligent bracelet etc.. Among these, non-invasive measurement techniques, in particular techniques for obtaining blood flow characteristics, blood parameters and/or performing blood analyses by means of optical measurements, have gained great use. An optical-based blood measuring device generally includes an emitting end and a detecting end, and is closely attached to a part of a user's body such as a wrist, a finger, an ear, a forehead, a cheek, or an eyeball, light radiation is transmitted into or reflected by the part of the body by the emitting end, and then light attenuated by the part of the body is detected by the detecting end to obtain a measurement signal. These measurement signals can be used to analyze and determine physiological parameters such as blood oxygen saturation, pulse, etc. Optical-based blood measurement techniques rely on the principle that light passing through this part of the body can be absorbed, reflected or refracted, thereby causing attenuation. Wherein the part of the body comprises components of skin, muscle, bone, fat, pigments, etc., the attenuation of light due to which is usually constant or considered to be substantially constant during the measurement, while the flow of blood in the blood vessels, in particular in the arterial blood vessels, causes a change in the attenuation of light. This is shown in that the measurement signal can be divided into a time-invariant Direct Current (DC) signal and a time-variant Alternating Current (AC) signal, and the AC signal in the measurement signal can be extracted to obtain blood flow characteristics, blood parameters and/or perform blood analysis. For example, Photoplethysmography (PPG) measures attenuated light reflected and absorbed by blood vessels and tissues of a human body to obtain a blood flow change of a volume pulse wave, thereby tracing a pulsation state of the blood vessels and measuring the pulse wave. As another example, Pulse Oximetry (Pulse Oximetry) measures the blood oxygen saturation, i.e., the volume of oxygenated hemoglobin bound by oxygen in blood as a percentage of the total bindable hemoglobin volume, by detecting the change in light absorption by blood, using the principle that the amount of light absorbed by arterial blood varies with the pulsation of the Pulse.
One of the key factors determining the measurement effect of the optical blood measurement technology is the Signal to Noise Ratio (SNR). In practice, the proportion of AC signals relative to DC signals in the measurement signal is often low, for example the AC/DC ratio at the wrist is typically less than one thousandth. In other words, the ratio of an AC signal based on light reflected from blood vessels to a DC signal based on light reflected from other components such as skin, muscle, bone, fat, etc. is low. On the other hand, factors such as background noise, electronic circuit disturbance and device state deviation also have a negative effect on the measurement effect, especially in the case of low SNR. The AC signal can be enhanced by increasing the intensity of the emitted light and increasing the sensitivity of the detector, but doing so will also enhance the DC signal at the same time as the AC signal, i.e. increase the noise component in the measurement signal. For this reason, it is necessary to increase the AC/DC ratio or increase the intensity of the AC signal with respect to the DC signal. US 10813578 discloses placing a reflector between the light source and the light detector, with the reflector reducing the light reflected to the light detector via a non-perfusing layer, such as the skin surface, while increasing the optical path length in a perfusing layer, such as a blood vessel. US 10537270 discloses forming an angle between the light irradiation direction of the light source and the detection direction of the light detector, thereby reducing the light reflected to the light detector via the non-perfused layer while increasing the optical path length in the perfused layer. However, these prior art solutions involve complicated structure and fine optical orientation design, and are difficult to adjust to actual requirements after product shipment, which is not suitable for large-scale applications such as adding to smart wearable devices.
In addition to obtaining blood flow characteristics, blood parameters and/or performing blood analysis by means of optical measurement, non-invasive measurement techniques may also obtain other physiological parameters related to the human body, such as pigmentation and distribution on the skin, etc., by means of optical measurement. However, there is a lack of an effective solution in the prior art to obtain these physiological parameters.
For this reason, a solution is needed, which can effectively measure physiological parameters of the user's body, such as blood parameters and pigment distribution, etc., and at the same time has good SNR and AC/DC ratio, and simple structure for adjustment, and can be applied to, for example, smart wearable devices such as smart watches, smart bracelets, etc. in close proximity to the user's wrist, etc.
Disclosure of Invention
In a first aspect, the present application provides a physiological parameter measuring device. The physiological parameter measuring device includes: an emission module, wherein the emission module is configured to emit light at one or more wavelengths, wherein the light emitted by the emission module satisfies a first polarization mode and illuminates a target under test; a detection module, wherein the detection module is configured to filter light reflected by the target under test, wherein the light filtered by the detection module satisfies a second polarization mode; and a processor. Wherein the processor is configured to determine a difference of the second polarization mode with respect to the first polarization mode according to the physiological parameter to be measured of the object to be measured and the wavelength of the light emitted by the emission module to optimize a measurement signal based on the light filtered by the detection module and used to determine the physiological parameter to be measured.
The technical solution described in the first aspect selectively enhances the influence of the reflected light at a specific depth of the skin on the measurement signal by a filtering manner based on a polarization mode, thereby facilitating obtaining of the physiological parameter related to the specific depth through the measurement signal.
In a second aspect, the present application provides a method for measuring a physiological parameter. The method comprises the following steps: emitting, by an emission module, light of one or more wavelengths, wherein the light emitted by the emission module satisfies a first polarization mode and illuminates a target under test; filtering, by a detection module, light reflected by the target to be detected, wherein the light filtered by the detection module satisfies a second polarization mode; and obtaining a measurement signal based on the light filtered by the detection module. Wherein the measurement signal is used for determining the physiological parameter to be measured of the measured target. Wherein a difference of the second polarization mode with respect to the first polarization mode is determined according to the physiological parameter to be measured and the wavelength of the light emitted by the emission module to optimize the measurement signal.
The technical solution described in the second aspect selectively enhances the influence of the reflected light at a specific depth of the skin on the measurement signal by means of polarization mode-based filtering, thereby facilitating obtaining of the physiological parameter related to the specific depth from the measurement signal.
In a third aspect, an embodiment of the present application provides a physiological parameter measuring terminal. The physiological parameter measurement terminal includes: an emission module, wherein the emission module is configured to emit light of one or more wavelengths, wherein the light emitted by the emission module satisfies a first polarization mode and illuminates a target under test; a first detection module, wherein the first detection module is configured to filter light reflected by the target under test, wherein the light filtered by the first detection module satisfies a first polarization analysis mode, and a first measurement signal is determined based on the light filtered by the first detection module; and a second detection module. Wherein the second detection module is configured to filter light reflected by the target under test, wherein the light filtered by the second detection module satisfies a second polarization analysis mode, and a second measurement signal is determined based on the light filtered by the second detection module. Wherein a difference of the first polarization analyzing pattern with respect to the first polarization analyzing pattern is different from a difference of the second polarization analyzing pattern with respect to the first polarization analyzing pattern.
The technical scheme described in the third aspect selectively enhances the influence of the reflected light at a specific depth of the skin on the measurement signal by a filtering manner based on the polarization mode, thereby facilitating the acquisition of the physiological parameter related to the specific depth through the measurement signal.
In a fourth aspect, an embodiment of the present application provides a physiological parameter measuring terminal. The physiological parameter measurement terminal includes: a first emission module, wherein the first emission module is configured to emit light of a first wavelength, wherein the light emitted by the first emission module satisfies a first polarization mode and illuminates a target under test; a second emitting module, wherein the second emitting module is configured to emit light of a second wavelength, wherein the light emitted by the second emitting module satisfies a second polarization mode and illuminates the target under test; and a detection module. The detection module is configured to filter light reflected by the target under test, wherein the light filtered by the detection module satisfies a first polarization analysis mode. Wherein a difference of the first polarization analyzing pattern with respect to the first polarization generating pattern is different from a difference of the first polarization analyzing pattern with respect to the second polarization generating pattern.
The technical solution described in the fourth aspect selectively enhances the influence of the reflected light at a specific depth of the skin on the measurement signal by means of polarization mode-based filtering, thereby facilitating obtaining of the physiological parameter related to the specific depth from the measurement signal.
In a fifth aspect, an embodiment of the present application provides a physiological parameter measuring terminal. The physiological parameter measurement terminal includes: a first emission module, wherein the first emission module is configured to emit light of one or more wavelengths, wherein the light emitted by the first emission module satisfies a first polarization mode and illuminates an object under test; a second emitting module, wherein the second emitting module is configured to emit light of one or more wavelengths, wherein the light emitted by the second emitting module satisfies a second polarization mode and illuminates the target under test; a first detection module, wherein the first detection module is configured to filter light reflected by the target under test, wherein the light filtered by the first detection module satisfies a first polarization analysis mode; and a second detection module, wherein the second detection module is configured to filter light reflected by the target under test, wherein the light filtered by the second detection module satisfies a second polarization analysis mode. The first polarization analysis mode is matched with the first polarization mode and is related to a first depth of the measured target, and the second polarization analysis mode is matched with the second polarization mode and is related to a second depth of the measured target.
The technical solution described in the fifth aspect selectively enhances the influence of the reflected light at a specific depth of the skin on the measurement signal by means of polarization mode-based filtering, so as to facilitate obtaining the physiological parameter related to the specific depth from the measurement signal.
In a sixth aspect, embodiments of the present application provide a physiological parameter measuring device. The physiological parameter measuring device includes: an emission module, wherein the emission module is configured to emit light at one or more wavelengths, wherein the light emitted by the emission module satisfies a first polarization mode and illuminates a target under test; and a detection module, wherein the detection module is configured to filter light reflected by the target under test, wherein the light filtered by the detection module satisfies a second polarization mode. Wherein the first polarization mode is different from the second polarization mode, the transmission module or the detection module being configured to adjust the difference of the second polarization mode with respect to the first polarization mode so as to maximize the ratio of the AC signal to the DC signal in the measurement signal.
The technical solution described in the sixth aspect selectively enhances the influence of the reflected light at a specific depth of the skin on the measurement signal by a filtering manner based on the polarization mode, thereby facilitating obtaining of the physiological parameter related to the specific depth through the measurement signal.
Drawings
In order to explain the technical solutions in the embodiments or background art of the present application, the drawings used in the embodiments or background art of the present application will be described below.
Fig. 1 shows a schematic diagram of a physiological parameter measuring device provided by an embodiment of the present application.
Fig. 2 shows a flow chart of a method for measuring a physiological parameter provided by an embodiment of the present application.
Fig. 3 shows a block diagram of a physiological parameter measurement terminal according to an embodiment of the present application.
Fig. 4 shows a block diagram of a physiological parameter measurement terminal according to another embodiment provided in the embodiments of the present application.
Fig. 5 shows a block diagram of a physiological parameter measurement terminal according to another embodiment provided in the present application.
Detailed Description
The embodiment of the application provides a physiological parameter measuring device, a terminal and a method, aiming at solving the technical problems that the physiological parameters of the body of a user, such as blood parameters, pigment distribution and the like, can be effectively measured, and meanwhile, the physiological parameters have better SNR and AC/DC ratio, are simple in structure and are beneficial to adjustment, and the physiological parameter measuring device can be applied to intelligent wearable equipment close to the wrist and other positions of the user, such as an intelligent watch, an intelligent bracelet and the like. The physiological parameter measuring device includes: an emission module, wherein the emission module is configured to emit light at one or more wavelengths, wherein the light emitted by the emission module satisfies a first polarization mode and illuminates a target under test; a detection module, wherein the detection module is configured to filter light reflected by the target under test, wherein the light filtered by the detection module satisfies a second polarization mode; and a processor. Wherein the processor is configured to determine a difference of the second polarization mode with respect to the first polarization mode according to the physiological parameter to be measured of the object to be measured and the wavelength of the light emitted by the emission module to optimize a measurement signal based on the light filtered by the detection module and used to determine the physiological parameter to be measured. In this way, the influence of the reflected light at a specific depth of the skin on the measurement signal is selectively enhanced by the polarization mode-based filtering manner, so that the physiological parameter related to the specific depth can be obtained through the measurement signal.
The embodiments of the present application can be used in any application scenarios including, but not limited to, any physiological measurement through the skin, such as measuring blood pressure, hemoglobin concentration, pulse, blood oxygen saturation, respiratory rate, blood perfusion index, blood flow reactivity, methemoglobin, carboxyhemoglobin, bilirubin, oxygen content, etc. through photoplethysmography or pulse waves, or measuring the above physiological parameters or any suitable human body related physiological parameters by measuring pulse wave transit time or measuring pulse wave amplitudes of different wavelengths or measuring pulse wave phases, etc.
The embodiments of the present application may be modified and improved according to specific application environments, and are not limited herein.
In order to make the technical field of the present application better understand, embodiments of the present application will be described below with reference to the accompanying drawings in the embodiments of the present application.
Referring to fig. 1, fig. 1 is a block diagram illustrating a physiological parameter measuring device according to an embodiment of the present disclosure. As shown in fig. 1, the physiological parameter measurement device 100 includes a transmission module 102, a detection module 104, and a processor 106. Wherein the transmitting module 102 is configured to transmit light of one or more wavelengths. The light emitted by the emitting module 102 satisfies the first polarization mode and illuminates the target under test. The emitting module 102 may include one or more light sources, while the detecting module 104 may also include one or more photodetectors or photodetector arrays. The object under test may be understood as a part of the user's body, e.g. the user's wrist, finger, ear, forehead, cheek or eyeball, which in fig. 1 is schematically indicated as epidermis layer 110 and dermis layer 120. The dermal layer 120 is located below the epidermal layer 110, which together are the skin of the part of the user's body. For example, when the physiological parameter measuring device 100 is attached to a position on the wrist of the user, the measured object is the skin of the user at the position, and the epidermis layer 110 and the dermis layer 120 represent the epidermis layer and the dermis layer of the skin at the position, respectively. The detection module 104 is configured to filter light reflected by the target under test. The light filtered by the detection module 104 satisfies the second polarization mode. Fig. 1 schematically shows three light paths L1, L2, and L3, where light emitted from the emitting module 102 is reflected by a target to be detected and then received by the detecting module 104. Here, the light represented by the light path L1 is reflected in the surface of the epidermis layer 110, the light represented by the light path L2 is emitted in the epidermis layer 110, and the light represented by the light path L3 is reflected in the dermis layer 120. It should be understood that the light paths L1, L2, and L3 shown in fig. 1 are only exemplary, and in practice, the light emitted by the emitting module 102 may reach the detecting module 104 after being reflected by the target to be detected along any suitable light path. The physiological parameter measuring device 100 obtains a measurement signal based on the light filtered by the detection module 104 and used for determining the physiological parameter to be measured of the object to be measured. Specifically, the light reflected from the detected object received by the detection module 104 is the light passing through the detected object, i.e. attenuated by the part of the body, and the measurement signal can be obtained by conventional technical means, such as photoelectric conversion, analog-to-digital conversion, and the like.
With reference to fig. 1, the layers of the skin include an epidermis layer, a dermis layer, and a subcutaneous tissue layer from the outermost layer, as known in the related art of human skin. The epidermis is free of blood vessels and can be further divided into a stratum corneum, a stratum lucidum, a stratum granulosum, a spinous cell layer and a stratum basale. The basal layer is the innermost layer of the epidermis and is connected with the dermis layer. The basal layer contains heme, bilirubin, melanin, etc. Wherein the activity of melanocytes determines the skin color, and the metabolism of melanocytes in normal range can protect cells from being reduced by ultraviolet rays and prevent ultraviolet rays from penetrating skin to damage deep cells. The dermis contains abundant blood vessels, and the subcutaneous tissue layer also contains abundant blood vessels. When light impinges on and enters the skin, it first reaches the outermost stratum corneum layer of the epidermis, then sequentially penetrates through the stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, and stratum basale, then penetrates into the dermis layer and continues to penetrate into the skin. Wherein the light reflected back from the stratum corneum does not carry blood related information, i.e. does not contribute to the AC signal of the measurement signal, but forms a DC signal, because the epidermis layer, in particular the stratum corneum, does not contain blood. Only light that penetrates into the dermis layer and passes through the blood vessels carries blood related information, i.e. will contribute to the AC signal. Thus, the main components of the DC signal in the measurement signal are reflected light from the epidermis layer and light backscattered at the stratum corneum. Taking fig. 1 as an example, the light indicated by the light path L1 and the light indicated by the light path L2 are reflected lights generated outside and inside the skin layer 110, that is, the lights indicated by the light path L1 and the light path L2 form only DC signals. In contrast, the light represented by the optical path L3 is reflected light generated inside the dermis layer 120, and the dermis layer 120 has abundant blood vessels, so the light represented by the optical path L3 may have blood-related information and contribute to the AC signal. Therefore, in order to increase the ratio of the AC signal to the DC signal, i.e., the AC/DC ratio, it is necessary to reduce the influence of the reflected light outside and inside the epidermis layer, for example, the optical path L1 and the optical path L2, and the light backscattered from the horny layer on the measurement signal obtained by the detection module 104 while enhancing the influence of the reflected light inside the dermis layer, for example, the optical path L3, on the measurement signal.
With continued reference to fig. 1, when light satisfying a specific polarization mode, such as linearly polarized light or plane polarized light, enters the skin, the stratum corneum at the outermost layer of the epidermis and the light reflected therein and backscattered from the stratum corneum, both maintain substantially the same polarization mode as the incident light. For example, when the incident light is linearly polarized light, the reflected light from the epidermis layer and the light backscattered from the horny layer are also linearly polarized light, and the vibration planes of the reflected light and the light are parallel to the vibration plane of the incident linearly polarized light. In contrast, as the incident light penetrates through the epidermis layer and enters the dermis layer below the epidermis layer, the light reflected inside the dermis layer, especially the light reflected by blood vessels, cannot maintain the original polarization mode. For example, the incident linearly polarized light may be a combination of various linearly polarized light after being reflected by blood vessels. Overall, the reflected light outside and inside the epidermis layer and the backscattered light from the stratum corneum will have a greater proportion or almost all of the light that is in accordance with the polarization mode of the incident light, whereas the reflected light inside the dermis layer will have less of a degree of uniformity with the polarization mode of the incident light. In this way, it is possible to filter out the reflected light outside and inside the epidermis layer and the light backscattered from the stratum corneum by means of a filtering method based on a polarization mode, such as an orthogonal polarization technique, to a relatively large extent, and to filter out the reflected light inside the dermis layer to a relatively small extent, thereby increasing the influence of the reflected light inside the dermis layer on the measurement signal, thereby increasing the AC/DC ratio in the measurement signal, improving the SNR and improving the detection effect. As mentioned above, because of the abundance of blood vessels in the dermis, increasing the effect of reflected light inside the dermis on the measurement signal helps to enhance the AC signal ratio, i.e., increase the AC/DC ratio, thereby facilitating the acquisition of blood related parameters as well as the acquisition of blood flow characteristics, blood parameters, and/or blood analysis.
With continued reference to fig. 1, in addition to increasing the AC/DC ratio to help obtain blood related parameters by increasing the effect of reflected light within the dermis on the measurement signal, it is sometimes desirable to obtain other human related physiological parameters such as pigment related physiological parameters. As described above, the innermost layer of the epidermal layer is the basal layer, which contains melanocytes, the activity of which determines the shade of skin color and which function to protect deep cells from uv rays. The DC signal in the measurement signal is mainly composed of reflected light from the epidermis layer and backscattered light from the stratum corneum layer, and a part of the DC signal is reflected light from the dermis layer. For this reason, the part of the DC signal reflected from the dermal layer can be effectively filtered by the polarization mode-based filtering method, so as to enhance the part of the DC signal reflected from the epidermal layer, thereby facilitating the detection of physiological parameters specific to the epidermal layer, such as melanocyte-related physiological parameters.
As described above, as incident light is irradiated onto a target to be measured and penetrates layer by layer, from the stratum corneum layer at the outermost side of the epidermis layer to the basal layer at the innermost side of the epidermis layer to the dermis layer, a large part or almost all of reflected light at the outer side and inner side of the epidermis layer and light backscattered from the stratum corneum layer generated during penetration of the incident light are consistent with the polarization mode of the incident light, and reflected light at the inner side of the dermis layer is hardly consistent with the polarization mode of the incident light. The relation between the polarization mode of the reflected light at different depths of the skin and the polarization mode of the incident light can be utilized for the purpose, and the influence of the reflected light at a specific depth of the skin on the measurement signal can be selectively enhanced through a filtering mode based on the polarization mode, so that the physiological parameter related to the specific depth can be obtained through the measurement signal. These technical features and technical effects in the technical solutions of the present application are described in detail below.
Referring to fig. 1, the light emitted by the emitting module 102 satisfies the first polarization mode and the light filtered by the detecting module 104 satisfies the second polarization mode. When the first polarization mode is the same as or almost the same as the second polarization mode, the part of the reflected light of the detected object, which can be consistent with the polarization mode of the incident light, namely the first polarization mode, is enhanced; in contrast, when the first polarization mode and the second polarization mode are different from each other greatly, for example, the first polarization mode is orthogonal polarization, the portion of the reflected light of the measured object, which can be different from the polarization mode of the incident light, that is, the portion of the reflected light of the measured object, which is different from the first polarization mode, is enhanced. For example, the first polarization mode may be linearly polarized light, the vibration plane of the linearly polarized light in the first polarization mode may be set to 0 degree, and the second polarization mode may be linearly polarized light, and the vibration plane may be set to 90 degrees. That is, the vibration plane of the linearly polarized light in the second polarization mode is rotated by 90 degrees with respect to the vibration plane of the linearly polarized light in the first polarization mode, that is, orthogonal polarization is formed. For another example, the first polarization mode may be linearly polarized light, and the vibration plane of the linearly polarized light in the first polarization mode may be 0 degrees, and the second polarization mode may be linearly polarized light and the vibration plane may be 0 degrees, and the second polarization mode may be the same as the first polarization mode. In one possible embodiment, the emission module 102 has a light source that generates light of one or more wavelengths and a Polarizer (Polarizer) that filters the light generated by the light source to allow only light that is sufficient to vibrate in a specific direction to pass through, thereby obtaining linearly polarized light in a first polarization mode; the detection module 104 is provided with an Analyzer (Analyzer) for filtering the light received by the detection module 104. The polarizer may be a polarizer, a nicols, or any suitable device. The analyzer may also be a polarizer or other suitable device. Thus, the first polarization mode is determined by the polarizer of the transmitting module 102 and the second polarization mode is determined by the analyzer of the detecting module 104, which means orthogonal polarization when the direction of vibration of the polarizer differs by 90 degrees from the direction of vibration of the analyzer.
With continued reference to fig. 1, the first polarization mode that the light emitted by the emitting module 102 needs to satisfy and the second polarization mode that the light filtered by the detecting module 104 needs to satisfy may be adjusted, for example, by adjusting the vibration direction of the polarizer of the emitting module 102 and the vibration direction of the analyzer of the detecting module 104, so as to determine the filtering manner for the light emitted by the emitting module 102 and reflected by the measured object, and further selectively enhance the influence of the reflected light at a specific depth of the skin on the measurement signal through the determined filtering manner, so as to achieve the effects of, for example, improving the AC/DC ratio in the measurement signal and improving the SNR. Since this filtering manner depends on the difference of the second polarization mode with respect to the first polarization mode, e.g. the rotation angle of the vibration direction of the analyzer with respect to the vibration direction of the polarizer, the filtering manner can be determined by adjusting the difference of the second polarization mode with respect to the first polarization mode, e.g. adjusting the second polarization mode or the first polarization mode. It should be understood that the difference between the second polarization mode and the first polarization mode is a relative concept, that is, the values of the first polarization mode and the second polarization mode in the same spatial reference frame are not important, and the difference between the first polarization mode and the second polarization mode is important. When light with different wavelengths penetrates through the same body part, the penetration depth can be different on the premise of keeping the polarization mode of the incident light basically unchanged. Generally, the longer the wavelength, the weaker the scattering effect and the deeper the maximum depth inside the skin where the original polarization mode can be maintained. When the wavelength is sufficiently long, the polarization mode of the incident light can be maintained to a considerable degree even by the reflected light in the dermis layer, for example, the reflected light obtained along the light path L3 shown in fig. 1 when the wavelength is sufficiently long maintains the polarization mode substantially in accordance with the incident light. In this case, in order to achieve the optimal AC/DC ratio, the difference between the second polarization mode and the first polarization mode needs to be controlled, and for example, the orthogonal polarization mode may not be used. This is because, when the reflected light in the dermis layer, i.e., the reflected light possibly carrying blood-related information, also remains in accordance with the vibration direction (set to 0 degrees) of the first polarization mode, e.g., the polarizer, setting the vibration direction of the second polarization mode, e.g., the analyzer, to 90 degrees means that the reflected light possibly carrying blood-related information is filtered out, and thus the optimal AC/DC ratio may not be achieved. Whereas by setting the direction of vibration of the second polarization mode, e.g. the analyzer, to some intermediate value, e.g. 80 degrees or 60 degrees, larger than 0 degrees and smaller than 90 degrees, an optimal AC/DC ratio may be achieved. How to control the difference between the second polarization mode and the first polarization mode to achieve the optimal AC/DC ratio needs to be determined in combination with the penetration depth that can be achieved in practice with the polarization mode of the incident light being substantially unchanged by the light emitted by the emitting module, or according to the wavelength of the light emitted by the emitting module. Therefore, the difference of the second polarization mode relative to the first polarization mode can be adjusted according to the wavelength of the light emitted by the emitting module, so that the AC/DC ratio in the measuring signal is improved as much as possible, the optical measuring signal obtained from the measured object is optimized, and the physiological parameters such as blood parameters can be acquired. On the other hand, depending on the particular physiological parameter to be acquired, it may be desirable to enhance the effect of reflected light at a depth within the epidermal layer of the skin on the measurement signal, for example to filter out the portion of the DC signal that is reflected light from the dermal layer, thereby enhancing the portion of the DC signal that is reflected light from the epidermal layer to facilitate detection of an epidermal-layer-specific physiological parameter, such as a melanocyte-related physiological parameter. In this case, in order to filter out the part of the DC signal that is reflected from the dermis layer, the difference of the second polarization mode with respect to the first polarization mode may be controlled such that the first polarization mode is substantially the same as the second polarization mode, and specifically the difference of the second polarization mode with respect to the first polarization mode may be adjusted according to the wavelength of the light emitted by the emitting module 102 so as to maximize the ratio of the DC signal in the measurement signal to the pigment-related part of the object to be measured. In summary, according to the specific physiological parameter to be acquired, the skin depth at which the physiological parameter is located, and the relationship between the wavelength of the incident light and the skin depth, the influence of the reflected light at a specific depth of the skin on the measurement signal can be selectively enhanced by the filtering manner based on the polarization mode, that is, by adjusting the difference between the second polarization mode and the first polarization mode, so as to be beneficial to obtaining the physiological parameter related to the specific depth through the measurement signal. Here, the relationship between the wavelength of the incident light and the skin depth may be understood as the maximum penetration depth corresponding to the skin depth, the lower limit or the minimum wavelength of the incident light which is suitably used, which can be achieved while keeping the polarization mode of the incident light substantially unchanged. This is because the longer the wavelength is, the weaker the scattering effect is, the deeper the maximum penetration depth of the polarization mode that can maintain the incident light inside the skin is, but the longer the wavelength is, which causes disadvantages such as a decrease in detection sensitivity, and therefore, the shorter the wavelength is, it is necessary to determine how to adjust the second polarization mode with respect to the first polarization mode according to the wavelength of the light emitted by the emission module, thereby achieving the best detection effect.
In some exemplary embodiments, the difference between the second polarization mode and the first polarization mode may be determined according to an empirical formula, a preset physiological model, or machine learning, etc., in the case that the wavelength of the light emitted or incident light by the emitting module is known, so as to increase the AC/DC ratio in the measurement signal as much as possible. These can be expanded and adjusted according to actual needs and in combination with the development of conventional technical means, and are not specifically limited herein. For example, assuming that the first polarization mode and the second polarization mode are linearly polarized and the difference of the second polarization mode with respect to the first polarization mode is expressed as a rotation angle of the corresponding vibration direction, the rotation angle is varied between 0 degrees and 360 degrees or may be varied between 0 degrees and 180 degrees, so that a table of the correspondence between the rotation angle of the vibration direction and the wavelength of the incident light may be established. For example, when the wavelength is 400nm to 2000nm, the rotation angle of the vibration direction is 90 degrees, i.e., the orthogonal polarization; when the wavelength is 2000nm to 10000nm, the rotation angle of the vibration direction is set as 80 degrees; when the wavelength is greater than 10000nm, the rotation angle in the vibration direction is 60 degrees. For another example, it is assumed that the first polarization mode and the second polarization mode are circularly polarized light or elliptically polarized light, and a difference between the second polarization mode and the first polarization mode is expressed as a difference in a change law of polarization direction of each of the circularly polarized light or the elliptically polarized light. For another example, one of the first polarization mode and the second polarization mode may be linearly polarized light and the other may be circularly polarized light or elliptically polarized light.
It should be understood that the processor 106 is configured to perform operations or instructions related to determining the difference of the second polarization mode with respect to the first polarization mode, for example, the processor 106 is configured to determine the difference of the second polarization mode with respect to the first polarization mode according to the physiological parameter to be measured of the object to be measured and the wavelength of the light emitted by the emission module 102 to optimize the measurement signal. The processor 106 may employ any suitable circuit hardware, computing architecture, and software layer algorithms, and is not specifically limited herein.
In some exemplary embodiments, when the physiological parameter to be measured is a blood-related parameter, the first polarization mode is different from the second polarization mode, and the difference of the second polarization mode with respect to the first polarization mode may be adjusted according to the wavelength of the light emitted by the emitting module 102, for example, the rotation angle of the vibration direction of the linearly polarized light as the second polarization mode with respect to the vibration direction of the linearly polarized light as the first polarization mode is set to 90 degrees, so as to maximize the ratio of the AC signal with respect to the DC signal in the measurement signal. The blood-related parameter comprises at least one of: blood pressure, hemoglobin concentration, pulse, blood oxygen saturation, respiratory rate, perfusion index, blood flow reactivity, methemoglobin, carboxyhemoglobin, bilirubin, oxygen content, blood lipids, and blood glucose. The blood-related parameter may be any physiological parameter that can be obtained according to blood-related information carried by reflected light of the dermis layer, or may be any physiological parameter that can be inferred from analysis of the AC signal in the measurement signal, which is not particularly limited.
In some exemplary embodiments, when the physiological parameter to be measured is a pigment-related parameter, the first polarization mode and the second polarization mode are substantially the same, and the difference of the second polarization mode relative to the first polarization mode may be adjusted according to the wavelength of the light emitted by the emission module 102, for example, the rotation angle of the vibration direction of the linearly polarized light as the second polarization mode relative to the vibration direction of the linearly polarized light as the first polarization mode is set to 0 degree, so as to maximize the occupancy ratio of the pigment-related portion of the DC signal in the measurement signal to the measured object. The pigment-related parameter includes a pigment distribution map, pigment interference, or pigment-related background noise. The pigment-related parameters can be used for drawing the pigment distribution of the part of the user body, and the application of cancer detection and the like is facilitated. In addition, pigment-related background noise can be obtained by obtaining the pigment-related parameters, and thus, the pigment-related background noise can be used for screening and filtering out the part corresponding to the pigment-related background noise in the DC signal in the measurement signal, thereby further improving the SNR. In addition, the difference of the second polarization mode relative to the first polarization mode can be adjusted according to the wavelength of the light emitted by the emitting module 102 so as to maximize the ratio of the DC signal in the measurement signal to the part of the measurement signal related to the epidermis-specific physiological parameter of the measured object. The physiological parameter specific to the epidermis layer may be, for example, a physiological parameter associated with a component within the spinous cell layer of the epidermis layer, such as a spiny polygonal cell therein.
Referring to fig. 2, fig. 2 is a schematic flow chart illustrating a method for measuring a physiological parameter according to an embodiment of the present application. As shown in fig. 2, the physiological parameter measurement method 200 includes the following steps.
S202: the method includes the steps of emitting light of one or more wavelengths through an emitting module, wherein the light emitted by the emitting module satisfies a first polarization mode and illuminates a measured object.
The structure and function of the transmitting module are similar to those of the transmitting module 102 shown in fig. 1, and are not described herein again.
S204: and filtering the light reflected by the detected target by a detection module, wherein the light filtered by the detection module meets a second polarization mode.
The structure and function of the detection module are similar to those of the detection module 104 shown in fig. 1, and are not described herein again.
S206: obtaining a measurement signal based on the light filtered by the detection module, wherein the measurement signal is used for determining the physiological parameter to be measured of the measured target.
Wherein a difference of the second polarization mode with respect to the first polarization mode is determined according to the physiological parameter to be measured and the wavelength of the light emitted by the emission module to optimize the measurement signal. According to the specific physiological parameter to be measured, the skin depth where the physiological parameter to be measured is located and the relation between the wavelength of incident light and the skin depth, the influence of reflected light at a specific depth of the skin on a measurement signal can be selectively enhanced through a filtering mode based on a polarization mode, namely, through adjusting the difference of a second polarization mode relative to a first polarization mode, so that the physiological parameter related to the specific depth can be obtained through the measurement signal. When the physiological parameter to be measured is a blood-related parameter, the first polarization mode is different from the second polarization mode, and the difference of the second polarization mode with respect to the first polarization mode may be adjusted according to the wavelength of the light emitted by the emitting module, for example, the rotation angle of the vibration direction of the linearly polarized light as the second polarization mode with respect to the vibration direction of the linearly polarized light as the first polarization mode is set to 90 degrees, thereby maximizing the ratio of the AC signal to the DC signal in the measurement signal. When the physiological parameter to be measured is a pigment-related parameter, the first polarization mode and the second polarization mode are substantially the same, and the difference between the second polarization mode and the first polarization mode can be adjusted according to the wavelength of the light emitted by the emission module, for example, the rotation angle of the vibration direction of the linearly polarized light as the second polarization mode relative to the vibration direction of the linearly polarized light as the first polarization mode is set to 0 degree, so as to maximize the ratio of the DC signal in the measurement signal to the pigment-related portion of the measured object. In summary, the relationship between the polarization mode of the reflected light at different depths of the skin and the polarization mode of the incident light can be utilized to selectively enhance the influence of the reflected light at a specific depth of the skin on the measurement signal through a filtering manner based on the polarization mode, thereby being beneficial to obtaining the physiological parameter related to the specific depth through the measurement signal.
Referring to fig. 3, fig. 3 is a block diagram illustrating a physiological parameter measuring terminal according to an embodiment of the present application. As shown in fig. 3, the physiological parameter measuring terminal 300 includes a transmitting module 302 and two detecting modules, i.e., a detecting module 310 and a detecting module 320. Wherein the emitting module 302 emits light of one or more wavelengths, the light emitted by the emitting module 302 satisfies a first polarization mode and illuminates a target under test (not shown). The emitting module 302 may include one or more light sources, while the detecting module 310 and the detecting module 320 may also each include one or more photodetectors or photodetector arrays. The object to be measured may be understood as a part of the user's body such as the user's wrist, finger, ear, forehead, cheek, or eyeball, and the part of the user's body may be understood as including the epidermis layer and the dermis layer. For example, when the physiological parameter measuring terminal 300 is pressed against a position on the user's wrist, then the measured object is the skin of the user's wrist at the position. The detection module 310 is configured to filter light reflected by the target under test, the light filtered by the detection module 310 satisfying a first polarization analysis mode. The detection module 320 is configured to filter light reflected by the target under test, the light filtered by the detection module 320 satisfying a second polarization analysis mode. In this way, the light emitted by the emitting module 302 satisfies the first polarization mode, and the detecting module 310 and the detecting module 320 filter the light reflected by the target according to the first polarization mode and the second polarization mode, so as to obtain the first measurement signal and the second measurement signal, respectively. Taking the linearly polarized light as an example, the vibration plane of the linearly polarized light corresponding to the first polarization mode is set to 0 degree, the vibration plane of the linearly polarized light corresponding to the first polarization analysis mode is set to 90 degrees, and the vibration plane of the linearly polarized light corresponding to the second polarization analysis mode is set to 45 degrees or an arbitrary angle between 0 degree and 90 degrees. Thus, the detecting module 310 using the first analyzing mode and the emitting module 302 using the first polarizing mode constitute orthogonal polarization, so that the part of the light reflected by the measured object, which is consistent with the polarization mode of the incident light, i.e. the first polarizing mode, is filtered, for example, the reflected light at the outer side and the inner side of the epidermis layer and the light backscattered from the horny layer, the reflected light or the scattered light occurring at these skin depths is linearly polarized light, and the vibration plane thereof is substantially parallel to the vibration plane of the incident linearly polarized light, i.e. 0 degree, and thus is filtered by the first analyzing mode of 90 degrees. However, when the wavelength of the incident light, i.e., the light emitted by the emitting module 302, is long enough, the polarization mode of the incident light can be maintained to a considerable degree even by the reflected light in the dermis layer, such that the filtering manner of the orthogonal polarization may not achieve the optimal AC/DC ratio. In contrast, the detection module 320 using the second polarization analysis mode may achieve a higher AC/DC ratio than the detection module 310 using the first polarization analysis mode because it uses some intermediate value greater than 0 degrees but less than 90 degrees, such as 80 degrees or 60 degrees. Therefore, by arranging the detection module 310 and the detection module 320 to filter the light reflected by the measured object according to the first and second polarization analysis modes, respectively, to obtain the first and second measurement signals, respectively, and then comparing the AC/DC ratio of the first measurement signal with the AC/DC ratio of the second measurement signal, a higher AC/DC ratio can be selected therefrom, thereby improving the measurement effect.
In the above embodiment, the difference of the first polarization analyzing pattern with respect to the first polarization analyzing pattern is 90 degrees, and the difference of the second polarization analyzing pattern with respect to the first polarization analyzing pattern is some intermediate value greater than 0 degrees and less than 90 degrees. In further exemplary embodiments, the difference of the first polarization analysis mode with respect to the first polarization mode is different from the difference of the second polarization analysis mode with respect to the first polarization mode, such that the AC/DC ratio of the first measurement signal is different from the AC/DC ratio of the second measurement signal, and by comparing the first measurement signal and the second measurement signal, a higher AC/DC ratio may be selected to improve the measurement effect. In addition, by utilizing the relation between the polarization modes of the reflected light with different depths of the skin and the polarization mode of the incident light and setting and adjusting the first analyzing mode and the second analyzing mode, the influence of the reflected light with different depths of the skin on the measuring signal can be selectively enhanced, so that the first measuring signal can more highlight the physiological parameter related to the first depth, and the second measuring signal can more highlight the physiological parameter related to the second depth. For example, if the first polarization mode is 90 degrees different from the first polarization mode, the first measurement signal is more prominent in the physiological parameters such as the light reflected by the dermis and the blood parameters related thereto, and if the second polarization mode is 0 degrees different from the first polarization mode, the second measurement signal is more prominent in the physiological parameters of the epidermis, such as the melanocyte related physiological parameters. In this way, by controlling the difference of the first polarization analysis mode relative to the first polarization analysis mode and the difference of the second polarization analysis mode relative to the first polarization analysis mode respectively, it is beneficial to obtain physiological parameters related to different skin penetration depths through different measurement signals respectively. For example, the difference of the first polarization analyzing mode relative to the first polarization generating mode is determined according to the first depth, and the difference of the second polarization analyzing mode relative to the first polarization generating mode is determined according to the second depth; the first measurement signal is used to determine a physiological parameter associated with a site of the object under test at a first depth, and the second measurement signal is used to determine a physiological parameter associated with a site of the object under test at a second depth.
It should be understood that fig. 3 only schematically shows the case of two detection modules, and the case of three detection modules or more detection modules may also be applied to the embodiment of the present application, particularly the embodiment illustrated in fig. 3, and these improvements or extensions should also be understood as part of the disclosure of the present application.
As shown in fig. 4, fig. 4 is a block diagram illustrating a physiological parameter measuring terminal according to another embodiment provided in the present application. As shown in fig. 4, the physiological parameter measurement terminal 400 includes another two transmitting modules, namely a transmitting module 402 and a transmitting module 404, and a detecting module 410. Wherein the emitting module 402 and the emitting module 404 emit light of one or more wavelengths, respectively. The light emitted by the emitting module 402 satisfies a first polarization mode and illuminates a target under test (not shown). The light emitted by the emitting module 404 satisfies the second polarization mode and illuminates the target under test. The emitting module 402 and the emitting module 404 may each include one or more light sources, while the detecting module 410 includes one or more photodetectors or photodetector arrays. The object to be measured may be understood as a part of the user's body such as the user's wrist, finger, ear, forehead, cheek, or eyeball, and the part of the user's body may be understood as including the epidermis layer and the dermis layer. For example, when the physiological parameter measurement terminal 400 is pressed against a position on the user's wrist, then the measured object is the skin of the user's wrist at the position. The detection module 410 is configured to filter light reflected by the target under test, the light filtered by the detection module 410 satisfying a first polarization analysis mode. Thus, the emitting module 402 and the emitting module 404 emit light satisfying the first polarization mode and the second polarization mode, respectively, and the two incident lights are reflected by the same target to be detected and filtered by the detecting module 410 to obtain a measurement signal. Taking the linearly polarized light as an example, the vibration plane of the linearly polarized light corresponding to the first polarization mode is set to 0 degree, the vibration plane of the linearly polarized light corresponding to the second polarization mode is set to 45 degrees or an arbitrary angle between 0 degree and 90 degrees, and the vibration plane of the linearly polarized light corresponding to the first polarization analysis mode is set to 90 degrees. Further, the emitting module 402 can be set to emit light of a first wavelength, the emitting module 404 can be set to emit light of a second wavelength, and by setting the difference between the first polarization analysis mode and the first polarization analysis mode according to the first wavelength and setting the difference between the second polarization analysis mode and the first polarization analysis mode according to the second wavelength, incident lights with different wavelengths can all obtain the optimal AC/DC ratio on the same measured object, thereby further improving the measurement effect. As described above, in order to improve the AC/DC ratio in the measurement signal as much as possible, a table may be established of the correspondence between the rotation angle in the vibration direction and the wavelength of the incident light, the rotation angle in the vibration direction being set to 90 degrees, that is, orthogonally off-set, when the wavelength is 400nm to 2000 nm; when the wavelength is 2000nm to 10000nm, the rotation angle in the vibration direction is 80 degrees. Therefore, assuming that the plane of vibration of the linearly polarized light corresponding to the first polarization mode is 0 degree, the plane of vibration of the linearly polarized light corresponding to the first analytical mode may be set to 90 degrees at a first wavelength of 900nm, and the plane of vibration of the linearly polarized light corresponding to the second analytical mode may be set to 80 degrees at a second wavelength of 3000 nm. In this way, the optimal AC/DC ratio can be obtained for both the incident light of the first wavelength and the incident light of the second wavelength, and the measurement signal can be analyzed by frequency domain analysis or frequency-based technical means because of the different wavelengths, thereby further improving the measurement effect. For example, the difference of the first polarization analyzing mode with respect to the first polarization mode is determined according to the first wavelength, and the difference of the first polarization analyzing mode with respect to the second polarization mode is determined according to the second wavelength.
It should be understood that fig. 4 only schematically shows the case of two transmitting modules, and the case of three transmitting modules or more transmitting modules may also be applied to the embodiment of the present application, particularly the embodiment illustrated in fig. 4, and these improvements or extensions should also be understood as part of the disclosure of the present application.
Fig. 5 shows a block diagram of a physiological parameter measurement terminal according to another embodiment provided in the present application. As shown in fig. 5, the physiological parameter measurement terminal 500 includes two transmission modules 502 and 504, and two detection modules 510 and 520. The polarization modes of the emitting modules 502 and 504 are the first polarization mode and the second polarization mode, and the polarization modes of the detecting modules 510 and 520 are the first polarization analyzing mode and the second polarization analyzing mode. Here, the first analyzing pattern and the first polarizing pattern constitute a pair for obtaining a physiological parameter related to the first skin penetration depth. The second analyzing mode and the second polarizing mode form a pair for obtaining the physiological parameter related to the second skin penetration depth. In connection with the embodiments shown in fig. 1 to 4, physiological parameters associated with different skin penetration depths can be obtained by providing different pairs of polarization and polarization modes. For example, a first measurement signal is based on the light filtered by the detection module 510, a second measurement signal is based on the light filtered by the detection module 520, the first measurement signal is used to determine a physiological parameter associated with the location of the target under test at the first depth, and the second measurement signal is used to determine a physiological parameter associated with the location of the target under test at the second depth.
It should be understood that fig. 5 only schematically shows the case of two transmitting modules and two detecting modules, i.e. two pairs of transmitting modules and detecting modules, and that the case of three pairs of transmitting modules and detecting modules or more pairs of transmitting modules and detecting modules may also be applied to the embodiments of the present application, in particular the embodiment illustrated in fig. 5, and that these improvements or developments should also be understood as part of the disclosure of the present application.
Referring to fig. 1 to 5, the "polarizing mode", "analyzing mode" or "polarization mode" mentioned in the embodiments of the present application should be understood to describe the vibration direction or vibration mode of the polarizer or analyzer, such as the vibration plane or vibration direction of linearly polarized light, and the change law of the polarization direction of circularly polarized light or elliptically polarized light. When the two polarization modes are the same, for example, a polarization mode is the same as an analyzing mode, it means that the vibration directions or vibration modes corresponding to the polarization modes are the same. While the difference between the two polarization modes is to be understood as a relative concept, such as the angle of rotation of the oscillation direction of one linearly polarized light relative to the oscillation direction of the other linearly polarized light.
Referring to fig. 1 to 5, an embodiment of the present application discloses a physiological parameter measuring device. The physiological parameter measuring device includes: an emission module, wherein the emission module is configured to emit light at one or more wavelengths, wherein the light emitted by the emission module satisfies a first polarization mode and illuminates a target under test; and a detection module, wherein the detection module is configured to filter light reflected by the target under test, wherein the light filtered by the detection module satisfies a second polarization mode. Wherein the first polarization mode is different from the second polarization mode, the transmission module or the detection module being configured to adjust the difference of the second polarization mode with respect to the first polarization mode so as to maximize the ratio of the AC signal to the DC signal in the measurement signal. In this way, by adjusting the corresponding polarization mode of the emitting module or the detecting module, the difference of the second polarization mode relative to the first polarization mode can be changed, so that the influence of the reflected light at a specific depth of the skin on the measurement signal can be selectively enhanced by a filtering manner based on the polarization mode, thereby being beneficial to obtaining the physiological parameter related to the specific depth through the measurement signal.
Referring to fig. 1 to 5, the "object to be measured" mentioned in the embodiments of the present application may be understood as a part of the user's body, such as the user's wrist, finger, ear, forehead, cheek or eyeball, or any object suitable for using the physiological parameter measuring device, terminal and method disclosed in the present application.
Referring to fig. 1 to 5, the "physiological parameter to be measured" in the embodiments of the present application should be understood to include, unless otherwise indicated: any physiological measurement performed through the skin, such as measuring blood pressure, hemoglobin concentration, pulse, blood oxygen saturation, respiratory rate, blood perfusion index, blood flow reactivity, methemoglobin, carboxyhemoglobin, bilirubin, oxygen content, etc. by photoplethysmography or pulse waves, or measuring the above-mentioned physiological parameters or any suitable human-related physiological parameters by measuring pulse wave transit time or measuring pulse wave amplitudes of different wavelengths or measuring pulse wave phases, etc.
The embodiments provided herein may be implemented in any one or combination of hardware, software, firmware, or solid state logic circuitry, and may be implemented in connection with signal processing, control, and/or application specific circuitry. Particular embodiments of the present application provide an apparatus or device that may include one or more processors (e.g., microprocessors, controllers, Digital Signal Processors (DSPs), Application Specific Integrated Circuits (ASICs), Field Programmable Gate Arrays (FPGAs), etc.) that process various computer-executable instructions to control the operation of the apparatus or device. Particular embodiments of the present application provide an apparatus or device that can include a system bus or data transfer system that couples the various components together. A system bus can include any of a variety of different bus structures or combination of different bus structures, such as a memory bus or memory controller, a peripheral bus, a universal serial bus, and/or a processor or local bus that utilizes any of a variety of bus architectures. The devices or apparatuses provided in the embodiments of the present application may be provided separately, or may be part of a system, or may be part of other devices or apparatuses.
Particular embodiments provided herein may include or be combined with computer-readable storage media, such as one or more storage devices capable of providing non-transitory data storage. The computer-readable storage medium/storage device may be configured to store data, programmers and/or instructions that, when executed by a processor of an apparatus or device provided by embodiments of the present application, cause the apparatus or device to perform operations associated therewith. The computer-readable storage medium/storage device may include one or more of the following features: volatile, non-volatile, dynamic, static, read/write, read-only, random access, sequential access, location addressability, file addressability, and content addressability. In one or more exemplary embodiments, the computer-readable storage medium/storage device may be integrated into a device or apparatus provided in the embodiments of the present application or belong to a common system. The computer-readable storage medium/memory device may include optical, semiconductor, and/or magnetic memory devices, etc., and may also include Random Access Memory (RAM), flash memory, read-only memory (ROM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), registers, a hard disk, a removable disk, a recordable and/or rewriteable Compact Disc (CD), a Digital Versatile Disc (DVD), a mass storage media device, or any other form of suitable storage media.
The above is an implementation manner of the embodiments of the present application, and it should be noted that the steps in the method described in the embodiments of the present application may be sequentially adjusted, combined, and deleted according to actual needs. In the above embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments. It is to be understood that the embodiments of the present application and the structures shown in the drawings are not to be construed as particularly limiting the devices or systems concerned. In other embodiments of the present application, an apparatus or system may include more or fewer components than the specific embodiments and figures, or may combine certain components, or may separate certain components, or may have a different arrangement of components. Those skilled in the art will understand that various modifications and changes may be made in the arrangement, operation, and details of the methods and apparatus described in the specific embodiments without departing from the spirit and scope of the embodiments herein; without departing from the principles of embodiments of the present application, several improvements and modifications may be made, and such improvements and modifications are also considered to be within the scope of the present application.

Claims (20)

1. A physiological parameter measuring device, characterized in that it comprises:
an emission module, wherein the emission module is configured to emit light at one or more wavelengths, wherein the light emitted by the emission module satisfies a first polarization mode and illuminates a target under test;
a detection module, wherein the detection module is configured to filter light reflected by the target under test, wherein the light filtered by the detection module satisfies a second polarization mode; and
a processor for processing the received data, wherein the processor is used for processing the received data,
wherein the processor is configured to determine a difference of the second polarization mode with respect to the first polarization mode according to the physiological parameter to be measured of the object to be measured and the wavelength of the light emitted by the emission module to optimize a measurement signal based on the light filtered by the detection module and used to determine the physiological parameter to be measured.
2. A physiological parameter measuring device according to claim 1, wherein determining the difference of the second polarization mode with respect to the first polarization mode according to the physiological parameter to be measured of the object to be measured and the wavelength of the light emitted by the emission module to optimize the measurement signal comprises:
when the physiological parameter to be measured is a blood-related parameter, the first polarization mode is different from the second polarization mode, and the difference of the second polarization mode relative to the first polarization mode is adjusted according to the wavelength of the light emitted by the emission module so as to maximize the ratio of the AC signal to the DC signal in the measurement signal.
3. A physiological parameter measuring device according to claim 2, wherein said blood related parameter comprises at least one of: blood pressure, hemoglobin concentration, pulse, blood oxygen saturation, respiratory rate, perfusion index, blood flow reactivity, methemoglobin, carboxyhemoglobin, bilirubin, oxygen content, blood lipids, and blood glucose.
4. A physiological parameter measuring device according to claim 1, wherein determining the difference of the second polarization mode with respect to the first polarization mode according to the physiological parameter to be measured of the object to be measured and the wavelength of the light emitted by the emission module to optimize the measurement signal comprises:
when the physiological parameter to be measured is a pigment-related parameter, the first polarization mode and the second polarization mode are substantially the same, and the difference of the second polarization mode relative to the first polarization mode is adjusted according to the wavelength of the light emitted by the emission module so as to maximize the ratio of the DC signal in the measurement signal to the pigment-related part of the measured object.
5. A physiological parameter measurement device according to claim 4, wherein said pigment-related parameter comprises a pigment distribution map, pigment interference, or pigment-related background noise.
6. A physiological parameter measurement device according to any one of claims 1 to 5, wherein the object to be measured is a wrist, finger, ear, forehead, cheek or eyeball of a user.
7. A physiological parameter measuring device according to any one of claims 1 to 5, wherein said first polarization mode is linearly polarized light having a first vibration direction, said second polarization mode is linearly polarized light having a second vibration direction, and the difference of said second polarization mode with respect to said first polarization mode is the rotation angle of said second vibration direction with respect to said first vibration direction.
8. A method of measuring a physiological parameter, the method comprising:
emitting, by an emission module, light of one or more wavelengths, wherein the light emitted by the emission module satisfies a first polarization mode and illuminates a target under test;
filtering, by a detection module, light reflected by the target to be detected, wherein the light filtered by the detection module satisfies a second polarization mode; and
obtaining a measurement signal based on the light filtered by the detection module, wherein the measurement signal is used for determining the physiological parameter to be measured of the measured object,
wherein a difference of the second polarization mode with respect to the first polarization mode is determined according to the physiological parameter to be measured and the wavelength of the light emitted by the emission module to optimize the measurement signal.
9. A physiological parameter measuring method according to claim 8, wherein the difference of the second polarization mode with respect to the first polarization mode is determined according to the physiological parameter to be measured and the wavelength of the light emitted by the emission module to optimize the measurement signal, comprising:
when the physiological parameter to be measured is a blood-related parameter, the first polarization mode is different from the second polarization mode, and the difference of the second polarization mode relative to the first polarization mode is adjusted according to the wavelength of the light emitted by the emission module so as to maximize the ratio of the AC signal to the DC signal in the measurement signal.
10. A physiological parameter measuring method according to claim 8, wherein the difference of the second polarization mode with respect to the first polarization mode is determined according to the physiological parameter to be measured and the wavelength of the light emitted by the emission module to optimize the measurement signal, comprising:
when the physiological parameter to be measured is a pigment-related parameter, the first polarization mode and the second polarization mode are substantially the same, and the difference of the second polarization mode relative to the first polarization mode is adjusted according to the wavelength of the light emitted by the emission module so as to maximize the ratio of the DC signal in the measurement signal to the pigment-related part of the measured object.
11. A physiological parameter measurement terminal, characterized in that the physiological parameter measurement terminal comprises:
an emission module, wherein the emission module is configured to emit light of one or more wavelengths, wherein the light emitted by the emission module satisfies a first polarization mode and illuminates a target under test;
a first detection module, wherein the first detection module is configured to filter light reflected by the target under test, wherein the light filtered by the first detection module satisfies a first polarization analysis mode, and a first measurement signal is determined based on the light filtered by the first detection module; and
a second detection module, wherein the second detection module is configured to filter light reflected by the target under test, wherein the light filtered by the second detection module satisfies a second polarization analysis mode, a second measurement signal is determined based on the light filtered by the second detection module,
wherein a difference of the first polarization analyzing pattern with respect to the first polarization analyzing pattern is different from a difference of the second polarization analyzing pattern with respect to the first polarization analyzing pattern.
12. A physiological parameter measurement terminal according to claim 11, wherein the difference of the first analyzing mode with respect to the first polarizing mode is determined according to a first depth, the difference of the second analyzing mode with respect to the first polarizing mode is determined according to a second depth, the first measurement signal is used for determining the physiological parameter related to the location of the object under test at the first depth, and the second measurement signal is used for determining the physiological parameter related to the location of the object under test at the second depth.
13. The physiological parameter measurement terminal of claim 12, wherein the physiological parameter associated with the location of the object under test at the first depth or the physiological parameter associated with the location of the object under test at the second depth comprises at least one of: blood pressure, hemoglobin concentration, pulse, blood oxygen saturation, respiratory rate, perfusion index, blood flow reactivity, methemoglobin, carboxyhemoglobin, bilirubin, oxygen content, blood lipids, and blood glucose.
14. A physiological parameter measurement terminal according to any of claims 11-13, wherein the object under test is a wrist, finger, ear, forehead, cheek or eyeball of a user.
15. A physiological parameter measurement terminal, characterized in that the physiological parameter measurement terminal comprises:
a first emission module, wherein the first emission module is configured to emit light of a first wavelength, wherein the light emitted by the first emission module satisfies a first polarization mode and illuminates a target under test;
a second emitting module, wherein the second emitting module is configured to emit light of a second wavelength, wherein the light emitted by the second emitting module satisfies a second polarization mode and illuminates the target under test; and
a detection module, wherein the detection module is configured to filter light reflected by the target under test, wherein the light filtered by the detection module satisfies a first polarization analysis mode,
wherein a difference of the first polarization analyzing pattern with respect to the first polarization generating pattern is different from a difference of the first polarization analyzing pattern with respect to the second polarization generating pattern.
16. A physiological parameter measurement terminal according to claim 15, wherein the difference of the first analyzing mode with respect to the first polarizing mode is determined in accordance with the first wavelength and the difference of the first analyzing mode with respect to the second polarizing mode is determined in accordance with the second wavelength.
17. A physiological parameter measurement terminal according to claim 15 or 16, wherein the object to be measured is a wrist, finger, ear, forehead, cheek or eyeball of a user.
18. A physiological parameter measurement terminal, characterized in that the physiological parameter measurement terminal comprises:
a first emission module, wherein the first emission module is configured to emit light of one or more wavelengths, wherein the light emitted by the first emission module satisfies a first polarization mode and illuminates an object under test;
a second emitting module, wherein the second emitting module is configured to emit light of one or more wavelengths, wherein the light emitted by the second emitting module satisfies a second polarization mode and illuminates the target under test;
a first detection module, wherein the first detection module is configured to filter light reflected by the target under test, wherein the light filtered by the first detection module satisfies a first polarization analysis mode; and
a second detection module, wherein the second detection module is configured to filter light reflected by the target under test, wherein the light filtered by the second detection module satisfies a second polarization analysis mode,
the first polarization analysis mode is matched with the first polarization mode and is related to a first depth of the measured target, and the second polarization analysis mode is matched with the second polarization mode and is related to a second depth of the measured target.
19. A physiological parameter measurement terminal according to claim 18, wherein a first measurement signal is based on the light filtered by the first detection module and a second measurement signal is based on the light filtered by the second detection module, the first measurement signal being used to determine a physiological parameter associated with the location of the object under test at the first depth and the second measurement signal being used to determine a physiological parameter associated with the location of the object under test at the second depth.
20. A physiological parameter measuring device, characterized in that it comprises:
an emission module, wherein the emission module is configured to emit light at one or more wavelengths, wherein the light emitted by the emission module satisfies a first polarization mode and illuminates a target under test; and
a detection module, wherein the detection module is configured to filter light reflected by the target under test, wherein the light filtered by the detection module satisfies a second polarization mode,
wherein the first polarization mode is different from the second polarization mode, the transmission module or the detection module being configured to adjust the difference of the second polarization mode with respect to the first polarization mode so as to maximize the ratio of the AC signal to the DC signal in the measurement signal.
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