CN113514461A - Digital pathological section scanning and analyzing device - Google Patents
Digital pathological section scanning and analyzing device Download PDFInfo
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- CN113514461A CN113514461A CN202110387415.9A CN202110387415A CN113514461A CN 113514461 A CN113514461 A CN 113514461A CN 202110387415 A CN202110387415 A CN 202110387415A CN 113514461 A CN113514461 A CN 113514461A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K7/00—Methods or arrangements for sensing record carriers, e.g. for reading patterns
- G06K7/10—Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation
- G06K7/14—Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light
- G06K7/1404—Methods for optical code recognition
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Abstract
The invention relates to the technical field of medical detection instruments and discloses a digital pathological section scanning and analyzing device which comprises a shell, wherein a closed door is hinged to the lower portion of one side of the shell, an accommodating opening is formed in the closed door, magnetic attraction closed sensors are respectively arranged on the outer walls of the two sides of the accommodating opening, a section accommodating box channel is formed in the accommodating opening, section clamping and pushing mechanisms are arranged on the two sides of the section accommodating box channel in a sliding mode, a section accommodating box is placed in the accommodating opening, the section accommodating box is clamped by the section clamping and pushing mechanisms and conveyed into the shell through the section accommodating box channel, and a section scanning and analyzing mechanism is arranged on the upper portion in the shell. The invention realizes the sequential scanning analysis of hundreds of glass slides by the arranged slice placing boxes, and a plurality of slice placing boxes can be sequentially placed in the channels of the slice placing boxes in the shell at intervals, thereby greatly improving the scanning analysis efficiency of slices.
Description
Technical Field
The invention relates to the technical field of medical detection instruments, in particular to a digital pathological section scanning and analyzing device.
Background
The digital pathological section scanner is an instrument which is manufactured by combining a microscopic technology, a computer processing technology and an image processing technology and can automatically scan and obtain clear, accurate and storable digital section information. The digital pathological section scanner can be used for browsing, analyzing, discussing and the like on the digital slide, is not limited by time and space, and is more convenient to operate, more powerful in function and more wide in application compared with a traditional slide reading mode under a microscope.
However, most of the digital pathological section scanners on the market load slides once, the number of the slides loaded once is limited, and is usually 5, and after one scan is completed, the scanner needs to be stopped, all slides are taken out from the stage at one time, new slides are put in, and a new round of scan is performed. In the way, the scanner is in a stagnation state in the process of loading and unloading the slide, so that the working efficiency is greatly reduced, and the time cost is improved.
Disclosure of Invention
The invention aims to provide a digital pathological section scanning and analyzing device, which realizes the sequential scanning and analysis of hundreds of glass slides through the arranged section placing boxes, and a plurality of section placing boxes can be sequentially placed in a channel of the section placing box in a shell at intervals, thereby greatly improving the scanning and analyzing efficiency of the sections.
The invention is realized in such a way, the digital pathological section scanning and analyzing device comprises a shell, wherein the lower part of one side of the shell is hinged with a closed door, the closed door is internally provided with a placing opening, the outer walls of the two sides of the placing opening are respectively provided with a magnetic suction closed sensor, the placing opening is internally provided with a section placing box channel, the two sides of the section placing box channel are slidably provided with a section clamping and pushing mechanism, a section placing box is placed in the placing opening and is clamped by the section clamping and pushing mechanism and is conveyed into the shell through the section placing box channel, the upper part in the shell is provided with a section scanning and analyzing mechanism, one side of the section scanning and analyzing mechanism is provided with an automatic section loading and unloading mechanism which sequentially unloads slides in the section placing box, and the section scanning and analyzing mechanism sequentially scans and analyzes the slides in the section placing box, the automatic slicing and clamping device is characterized in that a processor is further arranged in the shell, the processor is respectively in bidirectional connection with the slicing and scanning analysis mechanism, the slicing and automatic loading and unloading mechanism and the slicing and clamping and pushing mechanism, the output end of the processor is connected with a cloud end, and data after scanning processing are uploaded and stored by the cloud end.
Further, the box is placed in the section includes the box body, be provided with the slide groove in the box body, the both sides in slide groove evenly are provided with a plurality of location and detain, the location is detained and is provided with the slide mouth between detaining, slide mouth and slide looks adaptation, just the bottom in slide groove is provided with wears the export, the internal diameter of wearing the export is less than the width of slide.
Furthermore, a bar code area and a wax sheet scanning area are respectively arranged on two sides of the glass slide, the bar code area is used for determining the serial number of the slide, the wax sheet scanning area is used for placing wax sheets under the serial number, bar code scanning openings are respectively arranged on two sides of the slide placing box, the bar code scanning openings are right opposite to the bar code area of the glass slide, and the wax sheet scanning area is blocked inside the box body.
Further, the box body all is provided with the centre gripping groove near the both sides upper portion of bar code scanning mouth, centre gripping groove and section centre gripping push mechanism looks adaptation, section centre gripping push mechanism is including setting up the fixing base of placing box passageway both sides at the section, the top of fixing base is provided with the spout, be provided with the slider with its looks adaptation in the spout, the top of slider is provided with the slide, the upper portion of slide is provided with the centre gripping cylinder, the output of centre gripping cylinder is provided with the grip block, one side butt of grip block is on the inner wall in centre gripping groove.
Further, inside one side of slide is provided with the motor, the vertical downward just end of output of motor is provided with the gear, upper portion one side of fixing base is provided with the tooth's socket, be provided with the rack on the lateral wall of tooth's socket, the rack meshes with the gear mutually, the bottom of putting into the mouth is provided with the cushion, the section is placed the box and is placed on the cushion, grip block and grip groove looks butt realize the section and place the fixed of box, the motor drives the gear and rotates on the rack, the slider removes in the spout and realizes that the section is placed the box and removes to the section and place the box passageway.
Further, section scanning analysis mechanism is including setting up the connecting seat in casing top both sides, two the transmission is provided with scanning transmission lead screw between the connecting seat, scan the slider on the outer wall of scanning transmission lead screw has been cup jointed, the upper portion of scanning the slider is provided with the locating lever, the upper portion of locating lever extends to in the positioning seat in the casing inner wall, the lower part of scanning the slider is provided with the telescopic link, the bottom of telescopic link is provided with the microscope base, microscope base bottom middle part is provided with the swivel mount, the pivoted middle part is provided with spacing round pin axle, the upper portion of spacing round pin is connected on the microscope base, one side of microscope base is provided with pushing mechanism, pushing mechanism realizes the swivel mount and rotates, just the camera lens on the swivel mount is realized carrying out scanning analysis to barcode region, wax piece scanning zone on the slide.
Furthermore, the rotating seat is triangular prism-shaped, the corners of the rotating seat are arc-shaped surfaces, the lens is respectively arranged at the lower part of the arc-shaped surface of the rotating seat, the pushing mechanism comprises a pushing cylinder arranged on the mirror seat, the output end of the pushing cylinder extends into a rotating groove of the mirror seat, a pushing seat is arranged at the output end of the pushing cylinder, a limiting movable groove is arranged at the lower part of one side of the pushing seat, a shaft pin is arranged at the middle part of the limiting movable groove, a pushing block is sleeved on the outer wall of the shaft pin, a torsion spring is arranged on the shaft pin between the pushing block and the pushing seat, the two ends of the torsion spring are respectively fixed on the pushing block and the pushing seat, the lower part of the pushing block extends into a buckling groove in the arc-shaped surface of the rotating seat, when the pushing cylinder extends, the middle part of the pushing block is abutted against the side wall of the limiting movable groove, and the lower part of the pushing block is abutted against the buckling groove, when the pushing cylinder contracts, the middle part of the push block rotates towards the outer side of the limiting movable groove, and the lower part of the push block slides out of the buckling groove.
Further, the one end of scanning transmission lead screw runs through the connecting seat and the end is provided with the shaft coupling, the one end of shaft coupling is provided with scanning transmission motor, scanning transmission motor's bottom is provided with the frame, one side of frame is fixed on the inside wall of casing, two all be provided with fixing bearing on the connecting seat, scanning transmission lead screw's both ends all are connected with the fixing bearing transmission, scanning transmission lead screw is rotatory to be driven the scanning slider and slides, realizes the camera lens places the inside slide glass of box to the section of difference and scans the analysis.
Further, the automatic slicing and loading and unloading mechanism comprises a connecting rod, one end of the connecting rod is fixed on a scanning slide block on the slicing and scanning analysis mechanism, the other end of the connecting rod is provided with a moving seat, the moving seat is connected with a connecting seat in a sliding manner, a limiting groove is arranged on the bottom wall in the moving seat, a telescopic cylinder is arranged at one side in the limiting groove, one side of the telescopic cylinder is connected with the connecting seat, the bottom end of the connecting seat is matched with the limiting groove, a lifting cylinder is fixed at one side of the connecting seat, the top end of the lifting cylinder is provided with a lifting motor, the output end of the lifting motor penetrates into the lifting cylinder to be coaxially connected with the lifting screw rod, a lifting slide block is connected on the outer wall of the lifting screw rod in a sliding manner, a connecting plate is arranged at one side of the lifting slide block, one side of the connecting plate penetrates through the lifting cylinder and extends to the outside, and a connecting insertion piece is arranged at one side of the connecting plate, the connecting insertion sheet is positioned above the slice placing box.
Furthermore, both sides of the upper part of the connecting insertion piece are provided with check blocks, one opposite side of the two check blocks is provided with a laser sensor, the laser sensor is connected with the processor, the lifting slide block drives the connecting insertion piece to move up and down, the telescopic cylinder realizes that the connecting insertion piece is inserted into the section placing box, the width of the connecting insertion piece is smaller than the distance between two parallel positioning buckles in the slide groove, the two laser sensors are simultaneously shielded, the processor drives the lifting motor to rotate reversely at the moment, so that both ends of the slide are abutted between the two blocking blocks, the telescopic cylinder extends to expose the wax sheet scanning area of the glass slide, the slice scanning analysis mechanism realizes scanning analysis, while the bar code region of the other slide located in the lower portion is exposed, the lens also scans the bar code region of the other slide at the same time.
Compared with the prior art, the digital pathological section scanning and analyzing device provided by the invention has the following beneficial effects:
1. the sequential scanning analysis of hundreds of glass slides is realized through the arranged slice placing box, the placing of the glass slides is realized through the glass slide groove by the slice placing box, the separation of two adjacent glass slides is realized by the positioning buckle, so that the placing of multiple glass slides is realized, the bar code scanning port can facilitate the slice scanning analysis mechanism to sequence and position the glass slides, so that the scanning results can be conveniently paired, and a plurality of slice placing boxes can be sequentially placed in the channel of the slice placing box in the shell at intervals, so that the scanning analysis efficiency of the slices is greatly improved;
2. the slice placing box in the placing opening can be conveyed to the inside of the shell through the arranged slice clamping and pushing mechanism, the slice placing box is firstly placed on a cushion block on the placing opening, after the magnetic attraction closed sensor is closed to send out a signal, the processor sends a starting signal, the clamping block moves through the clamping cylinder, and finally is abutted against a clamping groove on the slice placing box to realize fixation, the gear moves on the rack through the rotation of the motor, and finally the slide block moves on the sliding groove to sequentially convey the slice placing box to the inside of the shell for scanning analysis;
3. the sequential scanning of a plurality of glass slides is realized by the arranged slide scanning and analyzing mechanism, when the glass slides are in the slide placing box, firstly, the first glass slide can scan a bar code area through a bar code scanning port, at the moment, two lenses on the rotary seat are in a rest state, and then, when the glass slides are slid out of the slide placing box, one lens scans and analyzes the wax sheet scanning area, the other lens scans the bar code area of the next glass slide, the last lens is in the rest state, so that the rotation of the rotary seat is realized by 60 degrees, each lens can be rested, the pushing mechanism pushes the push block to be clamped with the buckling groove and butted with the spacing movable groove to realize the fixation to push the rotary seat by utilizing the pushing cylinder, when the pushing cylinder is contracted, the push block cannot push the rotary seat reversely because of no fixed point, and the limiting pin can only rotate by 60 degrees at each time, thus, two lenses are respectively arranged in the bar code area and the wax sheet scanning area of the glass slide in each rotation;
4. when the connecting insert is inserted into the section placing box, when the two laser sensors are simultaneously shielded, the processor drives the lifting motor to rotate reversely at the moment, so that two ends of the slide are both abutted between the two blocking blocks, then the telescopic cylinder extends to realize that a wax sheet scanning area of the slide moves outwards and is exposed under the lens, the section scanning and analyzing mechanism realizes scanning and analysis, while a bar code area of the other slide positioned at the lower part is exposed, the lens also simultaneously scans a bar code area of the other slide, after the scanning is finished, the slide is pushed back to the original position by the blocking blocks, then the processor drives the lifting motor to rotate forwards, so that the blocking blocks are separated from the slide, then the telescopic cylinder extends, so that the connecting insert is separated from the section placing box, and then the processor drives the lifting motor to rotate forwards to realize the descending of the connecting insert, the slide glass loading and unloading device can be inserted into the next slide glass to repeat the actions, so that one-by-one scanning can be realized, and the slide glass loading and unloading device has the characteristics of simple process, low possibility of error, high efficiency and high speed, is easy to control, and greatly improves the quantity of slide glass scanning analysis.
Drawings
Fig. 1 is an external structural schematic diagram of a digital pathological section scanning and analyzing device provided by the invention;
fig. 2 is a front structural sectional view of the digital pathological section scanning and analyzing device provided by the invention;
fig. 3 is a schematic structural diagram of a slice clamping and pushing mechanism in the digital pathological slice scanning and analyzing device according to the present invention;
fig. 4 is a schematic top structural view of a slice placement box in the digital pathological section scanning analysis device according to the present invention;
fig. 5 is a schematic bottom structure view of a slice placement box in the digital pathological section scanning analysis device according to the present invention;
fig. 6 is a schematic structural diagram of a slice scanning and analyzing mechanism in the digital pathological slice scanning and analyzing device according to the present invention;
fig. 7 is a bottom view of a lens of a section scanning and analyzing mechanism in the digital pathological section scanning and analyzing device according to the present invention;
FIG. 8 is an enlarged view of the structure of area A in FIG. 7;
fig. 9 is a schematic side view of a push block of a section scanning and analyzing mechanism in the digital pathological section scanning and analyzing device according to the present invention;
fig. 10 is a schematic structural diagram of a slice loading and unloading mechanism in the digital pathological section scanning and analyzing device according to the present invention;
fig. 11 is a top view of a section loading and unloading mechanism in the digital pathological section scanning and analyzing apparatus according to the present invention;
FIG. 12 is a schematic view of the slide loading and unloading function of the automatic slide loading and unloading mechanism in the digital pathological section scanning and analyzing apparatus according to the present invention;
fig. 13 is a system connection block diagram of the digital pathological section scanning and analyzing device provided by the invention.
In the figure: 1-a shell, 2-a release opening, 3-a closed door and 4-a magnetic attraction closed sensor;
5-a slice placing box, 51-a box body, 52-a positioning buckle, 53-a slide groove, 54-a bar code scanning port, 55-a clamping groove and 56-a penetrating port;
6-a slice clamping and pushing mechanism, 61-a fixed seat, 62-a sliding chute, 63-a sliding block, 64-a sliding seat, 65-a clamping cylinder, 66-a clamping block, 67-a motor, 68-a gear, 69-a rack and 610-a cushion block;
7-slice scanning analysis mechanism, 71-connecting seat, 72-scanning slide block, 73-scanning transmission screw rod, 74-scanning transmission motor, 75-machine seat, 76-coupler, 77-positioning rod, 78-positioning seat, 79-telescopic rod, 710-mirror seat, 711-swivel seat, 712-lens, 713-pushing cylinder, 714-pushing seat, 715-pushing block, 716-shaft pin and 717-torsion spring;
8-slicing automatic loading and unloading mechanism, 81-connecting rod, 82-moving seat, 83-connecting seat, 84-telescopic cylinder, 85-limiting groove, 86-lifting cylinder, 87-lifting motor, 88-lifting screw rod, 89-lifting slide block, 810-connecting plate, 811-connecting inserting piece, 812-stop block and 813-laser sensor;
9-glass slide, 91-bar code zone, 92-wax sheet scanning zone.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The following describes the implementation of the present invention in detail with reference to specific embodiments.
The same or similar reference numerals in the drawings of the present embodiment correspond to the same or similar components; in the description of the present invention, it should be understood that if there is an orientation or positional relationship indicated by the terms "upper", "lower", "left", "right", etc. based on the orientation or positional relationship shown in the drawings, it is only for convenience of describing the present invention and simplifying the description, but it is not intended to indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and therefore, the terms describing the positional relationship in the drawings are only used for illustrative purposes and are not to be construed as limiting the present patent, and the specific meaning of the terms may be understood by those skilled in the art according to specific circumstances.
Referring to fig. 1-12, preferred embodiments of the present invention are provided.
A digital pathological section scanning and analyzing device comprises a shell 1, wherein the lower part of one side of the shell 1 is hinged with a closed door 3, a placing opening 2 is arranged in the closed door 3, the outer walls of the two sides of the placing opening 2 are respectively provided with a magnetic suction closed sensor 4, when the magnetic suction closed sensor 4 is opened, a processor can not send an instruction to work, after the magnetic suction closed sensor 4 is closed, the processor can send an instruction to work, a section placing box channel is arranged in the placing opening 2, the two sides of the section placing box channel are slidably provided with a section clamping and pushing mechanism 6, a section placing box 5 is placed in the placing opening 2, the section placing box 5 is clamped by the section clamping and pushing mechanism 6 and is conveyed into the shell 1 through the section placing box channel, the upper part in the shell 1 is provided with a section scanning and analyzing mechanism 7, one side of the section scanning and analyzing mechanism 7 is provided with an automatic section loading and unloading mechanism 8, section automatic handling mechanism 8 unloads slide glass 9 inside box 5 is placed to the section in proper order, section scanning analysis mechanism 7 scans the slide glass 9 of placing box 5 inside to the section in proper order and analyzes, still be provided with the treater in the casing 1, the treater respectively with section scanning analysis mechanism 7, section automatic handling mechanism 8, 6 both way junction of section centre gripping push mechanism, and the output of treater connects the high in the clouds, utilize the high in the clouds to upload the storage with the data after the scanning process, the follow-up staff of being convenient for transfers data.
In this embodiment, the section placing box 5 includes a box body 51, a slide groove 53 is arranged in the box body 51, a plurality of positioning buckles 52 are evenly arranged on two sides of the slide groove 53, a slide opening is arranged between the positioning buckles 52, the slide opening is matched with the slide glass 9, a penetrating opening 56 is arranged at the bottom end of the slide groove 53, the inner diameter of the penetrating opening 56 is smaller than the width of the slide glass 9, and the penetrating opening 56 can facilitate the penetration of a section automatic loading and unloading mechanism 811 of the section automatic loading and unloading mechanism, so as to realize the end abutment with the slide glass 9.
In this embodiment, a bar code area 91 and a wax sheet scanning area 92 are respectively disposed on two sides of the slide glass 9, the bar code area 91 is used for determining the serial number of the slide, the wax sheet scanning area 92 is used for placing the wax sheet under the serial number, two sides of the slide placing box 5 are respectively provided with a bar code scanning port 54, the bar code scanning port 54 faces the bar code area of the slide glass 9, the wax sheet scanning area 91 is blocked inside the box body 51, so that under the action of the section automatic loading and unloading mechanism 8, when the slide glass 9 moves out of the slide groove 53, the wax sheet scanning area 91 is exposed outside.
In this embodiment, the upper portions of two sides of the box body 51 close to the barcode scanning port 54 are provided with clamping grooves 55, the clamping grooves 55 are adapted to the slice clamping and pushing mechanism 6, the slice clamping and pushing mechanism 6 includes fixing seats 61 disposed at two sides of the channel of the slice placing box, the top end of the fixing seat 61 is provided with a sliding groove 62, the sliding groove 62 is provided with a sliding block 63 adapted thereto, the top end of the sliding block 63 is provided with a sliding seat 64, the upper portion of the sliding seat 64 is provided with a clamping cylinder 65, the output end of the clamping cylinder 65 is provided with a clamping block 66, one side of the clamping block 66 abuts against the inner wall of the clamping groove 55, one side of the inside of the sliding seat 64 is provided with a motor 67, the output end of the motor 67 is vertically downward and provided with a gear 68, one side of the upper portion of the fixing seat 61 is provided with a tooth space, the side wall of the tooth space is provided with a rack 69, the rack 69 is engaged with the gear 68, the bottom end of the placing port 2 is provided with a cushion block 610, the section is placed box 5 and is placed on cushion 610, so the back section can not place box 5 and move with ground contact in order to increase the friction when removing, grip block 66 realizes the section with grip tank 55 looks butt and places the fixed of box 5, motor 67 drives gear 68 and rotates on rack 69, slider 63 removes in spout 62 and realizes the section and place box 5 and place the box passageway removal to the section, after magnetism is inhaled closed sensor 4 and is closed the signal, the treater sends actuating signal, grip block 66 passes through grip cylinder 65 inside removal mutually, realize finally placing the mutual butt of grip tank 55 on the box 5 with the section and realize fixing, rethread motor 67 rotates, make gear 68 move on rack 69.
In this embodiment, the section scanning and analyzing mechanism 7 includes connecting seats 71 disposed at two sides of the top end in the housing 1, a scanning transmission screw rod 73 is disposed between the two connecting seats 71 in a transmission manner, a scanning slider 72 is sleeved on the outer wall of the scanning transmission screw rod 73, a positioning rod 77 is disposed at the upper portion of the scanning slider 72, the upper portion of the positioning rod 77 extends into a positioning seat 78 in the inner upper wall of the housing 1, an expansion link 79 is disposed at the lower portion of the scanning slider 72, a lens seat 710 is disposed at the bottom end of the expansion link 79, a rotation seat 711 is disposed at the middle portion of the bottom end of the lens seat 710, a limiting pin shaft is disposed at the middle portion of the rotation seat 711, the upper portion of the limiting pin is connected to the lens seat 710, a pushing mechanism is disposed at one side of the lens seat 710, the pushing mechanism realizes rotation of the rotation seat 711, and realizes scanning analysis of barcode regions 91 and wax scanning regions 92 on the slide 9, and the expansion link 79 can realize extension and contraction, therefore, the lens 712 is convenient to scan, the rotating seat 711 is in a triangular prism shape, corners of the rotating seat 711 are arc-shaped surfaces, the lens 712 is respectively arranged at the lower part of the arc-shaped surface of the rotating seat 711, the pushing mechanism comprises a pushing cylinder 713 arranged on the mirror seat 710, the output end of the pushing cylinder 713 extends into a rotating groove of the mirror seat 710, a pushing seat 714 is arranged at the output end of the pushing cylinder 713, a limiting movable groove is arranged at the lower part of one side of the pushing seat 714, a shaft pin 716 is arranged at the middle part of the limiting movable groove, a pushing block 715 is sleeved on the outer wall of the shaft pin 716, a torsion spring 717 is arranged on the shaft pin 716 between the pushing block 715 and the pushing seat 714, two ends of the torsion spring 717 are respectively fixed on the pushing block 715 and the pushing seat 714, the lower part of the pushing block 715 extends into a buckling groove in the arc-shaped surface of the rotating seat 711, when the pushing cylinder 713 extends, the middle part of the pushing block 715 abuts against the side wall of the limiting movable groove, and the lower part of the pushing block 715 abuts against the buckling groove, when the pushing cylinder 713 contracts, the middle of the push block 715 rotates to the outside of the limit movable groove, and the lower part of the push block 715 slides out from the buckle groove, when the glass slide 9 is inside the section placing box 5, firstly, the first glass slide 9 can scan the bar code area 91 through the bar code scanning port 54, at this time, two of the three lenses 712 on the rotary seat 711 are in a rest state, and then when the glass slide 9 is slid out of the section placing box 5, one of the lenses 712 scans and analyzes the wax sheet scanning area 92, the other lens 712 scans the bar code area 91 of the next glass slide 9, and the last lens 712 is in a rest state, so that the rotation of the rotary seat 711 by 60 degrees is realized, each lens 712 can be rested, and the push mechanism pushes the push block 715 to be clamped with the buckle groove by using the push cylinder 713 to abut against the limit movable groove to realize fixation to push the 714 of the rotary seat.
In this embodiment, one end of the scanning transmission screw 73 penetrates through the connecting base 71, and the end of the scanning transmission screw is provided with a coupling 76, one end of the coupling 76 is provided with a scanning transmission motor 74, the bottom end of the scanning transmission motor 74 is provided with a base 75, one side of the base 75 is fixed on the inner side wall of the housing 1, two connecting bases 71 are both provided with fixed bearings, two ends of the scanning transmission screw 73 are both in transmission connection with the fixed bearings, the scanning transmission screw 73 rotates to drive the scanning slider 72 to slide, so that the lens 712 can scan and analyze the slide glass 9 in different slide placing boxes 5.
In this embodiment, the slicing auto-assembling and disassembling mechanism 8 includes a connecting rod 81, one end of the connecting rod 81 is fixed on the scanning slide block 72 on the slicing scanning and analyzing mechanism 7, the other end of the connecting rod 81 is provided with a moving seat 82, a connecting seat 83 is slidably connected in the moving seat 82, a limiting groove 85 is provided on the bottom wall in the moving seat 82, one side in the limiting groove 85 is provided with a telescopic cylinder 84, one side of the telescopic cylinder 84 is connected with the connecting seat 83, the bottom end of the connecting seat 83 is matched with the limiting groove 85, one side of the connecting seat 83 is fixed with a lifting cylinder 86, the top end of the lifting cylinder 86 is provided with a lifting motor 87, the output end of the lifting motor 87 penetrates into the lifting cylinder 86 and is coaxially connected with a lifting screw rod 88, the outer wall of the lifting screw rod 88 is slidably connected with a lifting slide block 89, one side of the lifting slide block 89 is provided with a connecting plate 810, one side of the connecting plate 810 penetrates through the lifting cylinder 86 and extends to the outside, one side of the connecting plate 810 is provided with a connecting insertion piece 811, the connecting insertion piece 811 is positioned above the section placing box 5, and the loading and unloading function of each slide glass 9 in the section placing box 5 is realized through the arranged section automatic loading and unloading mechanism 8.
Specifically, both sides of the upper portion of the connecting insert 811 are provided with stoppers 812, one opposite sides of the two stoppers 812 are provided with laser sensors 813, the laser sensors 813 are connected with a processor, the lifting slider 89 drives the connecting insert 811 to move up and down, the telescopic cylinder 84 realizes that the connecting insert 811 is inserted into the section placing box 5, the width of the connecting insert 811 is smaller than the distance between the two parallel positioning buttons 52 in the slide groove 53, the two laser sensors 813 sense and are simultaneously shielded, the processor drives the lifting motor 87 to rotate reversely at the moment, so that both ends of the slide 9 are both abutted between the two stoppers 812, the telescopic cylinder 84 extends to realize that the wax sheet scanning area 92 of the slide 9 is exposed, the section scanning and analyzing mechanism 7 realizes scanning and analysis, the bar code area 91 of another slide 9 positioned at the lower portion is exposed at the moment, the lens 712 also scans the bar code area 91 of another slide 9 at the same time, after scanning, the glass slide 9 is pushed back to the original position by the stop 812, then the processor drives the lifting motor 87 to rotate forwards to separate the stop 812 from the glass slide 9, then the telescopic cylinder 84 extends to separate the connecting insertion piece 811 from the slice placing box 5, then the processor drives the lifting motor 87 to rotate forwards to realize the descending of the connecting insertion piece 811, and the connecting insertion piece 811 is inserted into the next glass slide 9 to repeat the actions, so that one-by-one scanning can be realized.
When the technical scheme is used, firstly, a plurality of glass slides are all placed in a slide placing box 5, sequential scanning and analysis of hundreds of glass slides 9 are realized through the arranged slide placing box 5, the slide placing box 5 realizes the placement of the glass slides 9 through a glass slide groove 53, a positioning buckle 52 realizes the separation of two adjacent glass slides 9, so that the placement of the plurality of glass slides 9 is realized, a bar code scanning port 54 can facilitate a slide scanning and analyzing mechanism 7 to sequence and position the glass slides 9, so as to facilitate the pairing of scanning results, the slide placing box 5 placed in a port 2 can be conveyed into a shell 1 through an arranged slide clamping and pushing mechanism 6, the slide placing box 5 is firstly placed on a cushion block 610 arranged on the port 2, the cushion block 610 can ensure that the slide placing box 5 cannot be contacted with the bottom surface when moving so as to increase friction force, after a magnetic attraction closed sensor 4 is closed to send a signal, the processor sends a starting signal, the clamping block 66 moves inside through the clamping cylinder 65, finally, the clamping block is abutted against the clamping groove 55 on the section placing box 5 to be fixed, then the motor 67 rotates to enable the gear 68 to move on the rack 69, finally, the slide block 63 moves on the sliding groove 62 to sequentially transport the section placing box 5 to the interior of the shell 1 for scanning analysis, sequential scanning of a plurality of glass slides 9 is realized through the arranged section scanning analysis mechanism 7, when the glass slides 9 are in the section placing box 5, firstly, a first glass slide 9 can scan the bar code area 91 through the bar code scanning port 54, at the moment, two of the three lenses 712 on the rotating seat 711 are in a rest state, and when the glass slides 9 slide is slid out of the section placing box 5 later, one of the lenses 712 scans and analyzes the wax scanning area 92, and the other lens 712 scans the bar code area 91 of the next glass slide 9, the last lens 712 is in a rest state, so that 60-degree rotation of the rotary seat 711 is realized, each lens 712 can be guaranteed to rest, the pushing mechanism utilizes the pushing cylinder 713 to push the push block 715 to be clamped with the buckling groove and to be abutted against the limiting movable groove to realize fixation to push the rotary seat 714, when the pushing cylinder 713 contracts, the push block 715 has no fixed point and cannot reversely push the rotary seat 714, and the limiting pin can only rotate 60 degrees at each time, so that two lenses 712 are respectively arranged in the bar code area 91 and the wax sheet scanning area 92 of the slide glass 9 in each rotation, the automatic slide loading and unloading mechanism 8 is arranged to realize loading and unloading of each slide glass 9 in the slide placing box 5, when the connecting inserting sheet 811 is inserted into the slide placing box 5, when two laser sensors are simultaneously shielded, the processor drives the lifting motor 87 to reversely rotate at the moment, so that two ends of the slide glass 9 are both abutted against the two stoppers 812, then the telescopic cylinder 84 is extended to move the wax sheet scanning area 92 of the slide glass 9 to the outside and expose the wax sheet scanning area under the lens 712, the slice scanning and analyzing mechanism 7 realizes scanning and analysis, and the bar code area 91 of another slide glass 9 at the lower part is exposed, the lens 712 also scans the bar code area 91 of another slide glass 9 at the same time, the slide glass 9 is pushed back to the original position by the stop 812 after the scanning is finished, then the processor drives the lifting motor 87 to rotate forward to separate the stop 812 from the slide glass 9, then the telescopic cylinder 84 extends to separate the connecting insertion piece 811 from the section placing box 5, then the processor drives the lifting motor 87 to rotate forward to realize the descending of the connecting insertion piece 811, and the operation is repeated when the slide glass is inserted into the next slide glass 9, the scanning can be realized one by one, and the process of loading and unloading the glass slide is simple, the error is not easy to occur, the method has the characteristics of high efficiency and high speed, the control is easy, and the quantity of the scanning analysis of the glass slide 9 is greatly improved.
Referring to fig. 13, the principle of the present technical solution is: firstly, a plurality of glass slides are all placed in a section placing box 5, sequential scanning analysis of hundreds of glass slides 9 is realized through the arranged section placing box 5, the section placing box 5 realizes the placing of the glass slides 9 through a glass slide groove 53, then after a magnetic suction sealing sensor 4 is closed, a processor sends a command to work, a section placing box channel is arranged in an placing opening 2, two sides of the section placing box channel are slidably provided with a section clamping and pushing mechanism 6, the section placing box 5 is placed in the placing opening 2, the section placing box 5 is clamped by the section clamping and pushing mechanism 6 and is conveyed into a shell 1 through the section placing box channel, then automatic section loading and unloading and scanning analysis are sequentially carried out, finally data is conveyed to a cloud end, medical staff download and watch at the cloud end, and for scanning of hundreds of glass slides 9, the technical scheme can realize the scanning analysis within one hour only, greatly improving the scanning efficiency of the slice.
In this embodiment, the whole operation process can be controlled by a computer, and PLC and the like are added to realize automatic operation control, and in each operation link, signal feedback can be performed by setting a sensor to realize sequential execution of steps, which are conventional knowledge of the current automatic control, and are not repeated in this embodiment.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (10)
1. The digital pathological section scanning and analyzing device is characterized by comprising a shell, wherein the lower part of one side of the shell is hinged with a closed door, the closed door is internally provided with a placing opening, the outer walls of the two sides of the placing opening are respectively provided with a magnetic attraction closed sensor, the placing opening is internally provided with a section placing box channel, the two sides of the section placing box channel are slidably provided with a section clamping and pushing mechanism, a section placing box is placed in the placing opening and is clamped by the section clamping and pushing mechanism and conveyed into the shell through the section placing box channel, the upper part in the shell is provided with a section scanning and analyzing mechanism, one side of the section scanning and analyzing mechanism is provided with an automatic section loading and unloading mechanism which sequentially unloads slides in the section placing box, and the section scanning and analyzing mechanism sequentially scans and analyzes the slides in the section placing box, the automatic slicing and clamping device is characterized in that a processor is further arranged in the shell, the processor is respectively in bidirectional connection with the slicing and scanning analysis mechanism, the slicing and automatic loading and unloading mechanism and the slicing and clamping and pushing mechanism, the output end of the processor is connected with a cloud end, and data after scanning processing are uploaded and stored by the cloud end.
2. The digital pathological section scanning and analyzing device of claim 1, wherein the section placement box comprises a box body, a slide groove is arranged in the box body, a plurality of positioning buckles are evenly arranged on two sides of the slide groove, a slide opening is arranged between the positioning buckles, the slide opening is matched with a slide, a through opening is arranged at the bottom end of the slide groove, and the inner diameter of the through opening is smaller than the width of the slide.
3. The digital pathological section scanning and analyzing device of claim 2, wherein a bar code area and a wax scanning area are respectively disposed on two sides of the slide, the bar code area is used for determining the serial number of the slide, the wax scanning area is used for placing the wax under the serial number, a bar code scanning opening is respectively disposed on two sides of the slide placing box, the bar code scanning opening is right opposite to the bar code area of the slide, and the wax scanning area is blocked inside the box body.
4. The digital pathological section scanning and analyzing device according to claim 3, wherein the upper portions of the two sides of the box body near the bar code scanning opening are provided with clamping grooves, the clamping grooves are matched with the section clamping and pushing mechanism, the section clamping and pushing mechanism comprises fixed seats arranged on two sides of the channel of the section placing box, the top ends of the fixed seats are provided with sliding grooves, sliding blocks matched with the sliding grooves are arranged in the sliding grooves, the top ends of the sliding blocks are provided with sliding seats, the upper portions of the sliding seats are provided with clamping cylinders, the output ends of the clamping cylinders are provided with clamping blocks, and one sides of the clamping blocks abut against the inner walls of the clamping grooves.
5. The digital pathological section scanning and analyzing device of claim 4, wherein a motor is disposed on one side of the interior of the sliding base, the output end of the motor is vertically downward, a gear is disposed at the end of the motor, a tooth socket is disposed on one side of the upper portion of the fixing base, a rack is disposed on the side wall of the tooth socket, the rack is meshed with the gear, a cushion block is disposed at the bottom end of the placing opening, the section placing box is placed on the cushion block, the clamping block is abutted against the clamping groove to fix the section placing box, the motor drives the gear to rotate on the rack, and the slide block moves in the sliding groove to move the section placing box into the section placing box channel.
6. The digital pathological section scanning and analyzing device of claim 5, wherein the section scanning and analyzing mechanism comprises connecting seats disposed on two sides of the top end of the housing, a scanning transmission screw rod is disposed between the two connecting seats, a scanning slider is sleeved on the outer wall of the scanning transmission screw rod, a positioning rod is disposed on the upper portion of the scanning slider, the upper portion of the positioning rod extends into a positioning seat in the upper wall of the housing, a telescopic rod is disposed on the lower portion of the scanning slider, a mirror base is disposed at the bottom end of the telescopic rod, a rotary base is disposed in the middle of the bottom end of the mirror base, a limit pin shaft is disposed in the middle of the rotary base, the upper portion of the limit pin is connected to the mirror base, a pushing mechanism is disposed on one side of the mirror base, the pushing mechanism realizes rotation of the rotary base, and a lens on the rotary base realizes a barcode region, and a barcode region on a slide glass, And scanning and analyzing the wax sheet scanning area.
7. The digital pathological section scanning and analyzing device of claim 6, wherein the rotating base is in a shape of a triangular prism and the corners are in an arc shape, the lenses are respectively disposed at the lower portions of the arc shape of the rotating base, the pushing mechanism comprises a pushing cylinder disposed on the mirror base, the output end of the pushing cylinder extends into the rotating groove of the mirror base, a pushing base is disposed at the output end of the pushing cylinder, a position-limiting movable groove is disposed at the lower portion of one side of the pushing base, a shaft pin is disposed in the middle of the position-limiting movable groove, a pushing block is sleeved on the outer wall of the shaft pin, a torsion spring is disposed on the shaft pin between the pushing block and the pushing base, the two ends of the torsion spring are respectively fixed on the pushing block and the pushing base, the lower portion of the pushing block extends into a catching groove in the arc shape of the rotating base, and the middle portion of the pushing block abuts against the side wall of the position-limiting movable groove when the pushing cylinder extends, and the lower part of the push block is abutted against the buckling groove, when the push cylinder contracts, the middle part of the push block rotates towards the outer side of the limiting movable groove, and the lower part of the push block slides out of the buckling groove.
8. The digital pathological section scanning and analyzing device of claim 7, wherein one end of the scanning transmission screw rod penetrates through the connecting seats, and the end of the scanning transmission screw rod is provided with a coupler, one end of the coupler is provided with a scanning transmission motor, the bottom end of the scanning transmission motor is provided with a base, one side of the base is fixed on the inner side wall of the shell, two connecting seats are provided with fixing bearings, two ends of the scanning transmission screw rod are in transmission connection with the fixing bearings, the scanning transmission screw rod rotates to drive the scanning slider to slide, so that the lens can scan and analyze the slides in different section placing boxes.
9. The digital pathological section scanning and analyzing device of claim 8, wherein the automatic section loading and unloading mechanism comprises a connecting rod, one end of the connecting rod is fixed on a scanning slider on the scanning and analyzing mechanism, the other end of the connecting rod is provided with a moving seat, a connecting seat is slidably connected in the moving seat, a limiting groove is arranged on the bottom wall in the moving seat, a telescopic cylinder is arranged on one side in the limiting groove, a connecting seat is connected on one side of the telescopic cylinder, the bottom end of the connecting seat is matched with the limiting groove, a lifting cylinder is fixed on one side of the connecting seat, a lifting motor is arranged at the top end of the lifting cylinder, the output end of the lifting motor penetrates into the lifting cylinder and is coaxially connected with a lifting screw rod, a lifting slider is slidably connected on the outer wall of the lifting screw rod, and a connecting plate is arranged on one side of the lifting slider, one side of connecting plate is run through a section of thick bamboo and is extended to the outside, one side of connecting plate is provided with the connection inserted sheet, it is located the section of thick bamboo and places the top of box to connect the inserted sheet.
10. The digital pathological section scanning and analyzing device of claim 9, wherein two stoppers are disposed on both sides of the upper portion of the connecting insert, a laser sensor is disposed on the opposite side of each of the stoppers, the laser sensor is connected to the processor, the lifting slider drives the connecting insert to move up and down, the telescopic cylinder realizes that the connecting insert is inserted into the section placing box, the width of the connecting insert is smaller than the distance between two parallel positioning buttons in the slide groove, the two laser sensors are simultaneously shielded, the processor drives the lifting motor to rotate reversely, so that both ends of the slide are abutted between the two stoppers, the telescopic cylinder extends to realize that the wax sheet scanning area of the slide is exposed, the section scanning and analyzing mechanism realizes scanning and analyzing, and the bar code area of the other slide located at the lower portion is exposed, the lens also simultaneously scans the barcode region of another slide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110387415.9A CN113514461A (en) | 2021-04-09 | 2021-04-09 | Digital pathological section scanning and analyzing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110387415.9A CN113514461A (en) | 2021-04-09 | 2021-04-09 | Digital pathological section scanning and analyzing device |
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| CN113514461A true CN113514461A (en) | 2021-10-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202110387415.9A Withdrawn CN113514461A (en) | 2021-04-09 | 2021-04-09 | Digital pathological section scanning and analyzing device |
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| CN (1) | CN113514461A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116500248A (en) * | 2023-06-27 | 2023-07-28 | 广州盛安医学检验有限公司 | Pathological section scanning device and method |
| CN116593464A (en) * | 2023-05-23 | 2023-08-15 | 丽水瑞联医疗科技有限公司 | Pathological section scanner based on embedded control |
-
2021
- 2021-04-09 CN CN202110387415.9A patent/CN113514461A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116593464A (en) * | 2023-05-23 | 2023-08-15 | 丽水瑞联医疗科技有限公司 | Pathological section scanner based on embedded control |
| CN116593464B (en) * | 2023-05-23 | 2023-11-14 | 丽水瑞联医疗科技有限公司 | Pathological section scanner based on embedded control |
| CN116500248A (en) * | 2023-06-27 | 2023-07-28 | 广州盛安医学检验有限公司 | Pathological section scanning device and method |
| CN116500248B (en) * | 2023-06-27 | 2023-09-05 | 广州盛安医学检验有限公司 | Pathological section scanning device and method |
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Application publication date: 20211019 |