CN113509507A - Wound healing medicine and preparation method thereof - Google Patents
Wound healing medicine and preparation method thereof Download PDFInfo
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- CN113509507A CN113509507A CN202110442431.3A CN202110442431A CN113509507A CN 113509507 A CN113509507 A CN 113509507A CN 202110442431 A CN202110442431 A CN 202110442431A CN 113509507 A CN113509507 A CN 113509507A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Abstract
The invention provides a wound healing medicament and a preparation method thereof, which relate to the field of medicaments for promoting wound healing and are prepared from the following medicaments in part by mass: 1-3 g of borneol, 1-4 g of garden burnet root, 2-4 g of rhubarb, 1-3 g of calcined oyster and 1-4 g of white granulated sugar, the prepared wound healing medicament is a pure natural product, has no toxic or side effect, can relieve pain caused by wound damage, is more convenient to use and has better use body feeling compared with the conventional bandage which is coated with the medicament to the wound.
Description
Technical Field
The invention relates to the field of medicaments for promoting wound healing, in particular to a medicament for promoting wound healing and a preparation method thereof.
Background
Wound healing refers to the healing process after the body is subjected to external force and the skin and other tissues are separated or damaged, and comprises the complex combination of regeneration of various tissues, granulation tissue proliferation and scar tissue formation, and the synergistic effect of various processes is shown.
In most cases, the process of wound healing can be summarized as acute inflammation, cell proliferation, scar formation, epidermis and other tissue regeneration, that is, nutrients supplied by the internal circulation of the human body, so that the wound has the ability of self healing, but the ability is not infinitely amplified, for example, bedsore, scald, incised wound and the autoimmune problem of diabetics, the wound caused by non-healing needs external treatment to assist wound healing, and the medicines for wound healing at present are mostly applied to the bandage to be attached to the wound, so that the wound is assisted by the auxiliary treatment, and then external impurities are prevented from being attached to the wound through the bandage, so that the wound is aggravated, but the use feeling of the user is combined, the bandage is placed on the wound, the pressure applied by the bandage is firstly, so that the pain feeling of the wound is aggravated, and then the bandage is wound or attached, the human body always has foreign matters, and the comprehensive use feeling is not good.
Therefore, a natural medicine which can treat the wound, does not need a bandage for assistance in the treatment and has good curative effect is needed to improve the use limitation in the current wound healing treatment.
Disclosure of Invention
The invention aims to provide a wound healing medicament and a preparation method thereof, and aims to solve the technical problems.
In order to solve the technical problems, the invention adopts the following technical scheme: the preparation method of the wound healing medicine is characterized by comprising the following medicines by mass:
1-3 g of borneol, 1-4 g of sanguisorba officinalis, 2-4 g of rhubarb, 1-3 g of calcined oyster and 1-4 g of white granulated sugar;
the manufacturing method comprises the following steps:
1) selecting radix Sangusorbae, radix et rhizoma Rhei and Concha Ostreae preparata;
2) cleaning garden burnet, rhubarb and calcined oyster, and drying in the air after cleaning;
3) placing the dried garden burnet, rhubarb and calcined oyster shell in a high-temperature disinfection cabinet for disinfection treatment;
4) pulverizing sterilized radix Sangusorbae, radix et rhizoma Rhei, Concha Ostreae preparata, and white sugar in a pulverizer, decocting in a pot, removing water in a freeze-drying machine when decocting to viscous state, and pulverizing into powder after removing water;
5) mixing Borneolum Syntheticum and the powder to obtain the wound healing medicine.
Preferably, the sterilization temperature in the step 3) is one hundred ℃, and the sterilization time is three minutes.
Preferably, the garden burnet root, the rhubarb and the calcined oyster shell in the step 3) are sterilized by drying.
Borneol has the functions of inducing resuscitation and refreshing mind, clearing heat and removing toxicity, improving eyesight and removing nebula, and reducing swelling and relieving pain, and is used for treating sore and ulcer with swelling and pain and unhealing ulcer.
Sanguisorba officinalis is a hemostatic drug, can be used for treating various bleeding syndromes due to blood heat, gingival bleeding patients, upper gastrointestinal bleeding patients and tuberculosis hemoptysis patients, can help to shorten bleeding time and blood coagulation time, and can also be used for treating burn and scald.
Rhubarb is ground into powder and prepared into external application for treating burns and scalds, has the function of cooling blood and the efficacy of promoting blood circulation, and can be used for relieving symptoms such as conjunctival congestion, swollen throat, gum swelling and pain and the like in the aspect of detoxification, purgation and accumulation such as food siltation of gastrointestinal tract can be performed by using rhubarb for administration, gastrointestinal tract can be opened rapidly, intestinal obstruction, pancreatitis and gastrointestinal tract blockage can be relieved, and the rhubarb has good curative effect on short-time acute diseases.
Forged oyster is a medicinal material prepared from oyster, has the same and different drug effects as oyster, has the main effects of astringing and arresting discharge and strong deacidification effect, and can be used for treating stomachache, gastric acid and other diseases.
White sugar is sweet in taste, neutral in nature, and capable of entering spleen and lung channels, has the effects of moistening lung and regulating the middle warmer, promoting the production of body fluid to relieve cough, soothing liver qi, nourishing yin, seasoning, removing halitosis, treating sore, removing alcoholism and removing bittern poison, can supplement body fluid and energy, improve blood sugar and the like when being generally applied to treatment of diseases such as cough, lung dryness, lung deficiency, cough and asthma, toothache, hypoglycemia and the like, and is found by modern medical research, the white sugar can change the wound healing speed and promote the growth of tissue cells.
The invention has the beneficial effects that:
1. the wound healing medicine prepared by the invention has high smearing adhesion degree when being smeared on a wound, so that the medicine components can be effectively resisted to the surface of the wound, thereby accelerating the healing of the wound, and then the wound is covered, thereby avoiding the wound inflammation or lesion problem caused by the attachment of external bacteria to the surface of the wound.
2. The wound healing medicine prepared by the invention has obvious scabbing speed when being applied to a wound, obviously reduces the pain of most volunteers after being applied, has good use feeling, and has high scabbing and falling speed and good whole wound healing effect after scabbing.
3. The wound healing drug prepared by the invention is a pure natural product, has no toxic or side effect, can relieve pain caused by wound damage, and is more convenient to use and better in use feeling compared with the traditional bandage for coating the drug on the wound.
Detailed Description
Based on the embodiments in the implementation, other embodiments obtained by those skilled in the art without any creative efforts belong to the protection scope of the present invention.
Specific embodiments of the present invention are described below.
1. Preparing wound healing medicaments with different proportions
Example 1
The preparation method of the wound healing medicine is characterized by comprising the following medicines by mass:
1 g of borneol, 1 g of garden burnet root, 2 g of rhubarb, 1 g of calcined oyster and 1 g of white granulated sugar;
the manufacturing method comprises the following steps:
1) garden burnet root, rhubarb and calcined oyster shell;
2) cleaning garden burnet, rhubarb and calcined oyster, and drying in the air after cleaning;
3) placing the dried garden burnet, rhubarb and calcined oyster shell in a high-temperature disinfection cabinet for disinfection treatment;
4) pulverizing sterilized radix Sangusorbae, radix et rhizoma Rhei, Concha Ostreae preparata, and white sugar in a pulverizer, decocting in a pot, removing water in a freeze-drying machine when decocting to viscous state, and pulverizing into powder after removing water;
5) mixing Borneolum Syntheticum and the powder to obtain the wound healing medicine.
Example 2
The preparation method of the wound healing medicine is characterized by comprising the following medicines by mass:
1 g of borneol, 2 g of garden burnet root, 2 g of rhubarb, 1 g of calcined oyster and 2 g of white granulated sugar;
the manufacturing method comprises the following steps:
1) garden burnet root, rhubarb and calcined oyster shell;
2) cleaning garden burnet, rhubarb and calcined oyster, and drying in the air after cleaning;
3) placing the dried garden burnet, rhubarb and calcined oyster shell in a high-temperature disinfection cabinet for disinfection treatment;
4) pulverizing sterilized radix Sangusorbae, radix et rhizoma Rhei, Concha Ostreae preparata, and white sugar in a pulverizer, decocting in a pot, removing water in a freeze-drying machine when decocting to viscous state, and pulverizing into powder after removing water;
5) mixing Borneolum Syntheticum and the powder to obtain the wound healing medicine.
Example 3
The preparation method of the wound healing medicine is characterized by comprising the following medicines by mass:
3 g of borneol, 4 g of garden burnet root, 4 g of rhubarb, 3 g of calcined oyster and 4 g of white granulated sugar;
the manufacturing method comprises the following steps:
1) garden burnet root, rhubarb and calcined oyster shell;
2) cleaning garden burnet, rhubarb and calcined oyster, and drying in the air after cleaning;
3) placing the dried garden burnet, rhubarb and calcined oyster shell in a high-temperature disinfection cabinet for disinfection treatment;
4) pulverizing sterilized radix Sangusorbae, radix et rhizoma Rhei, Concha Ostreae preparata, and white sugar in a pulverizer, decocting in a pot, removing water in a freeze-drying machine when decocting to viscous state, and pulverizing into powder after removing water;
5) mixing Borneolum Syntheticum and the powder to obtain the wound healing medicine.
2. Degree of adhesion of wound healing drugs to wound
40 volunteers (18-25 years old) with non-healing or poor healing ability of the wound were selected, randomly and evenly divided into 4 groups of 10 persons each, group 1 used the wound-healing drug prepared in example 1, group 2 used the wound-healing drug prepared in example 2, group 3 used the wound-healing drug prepared in example 3, group 4 used no wound-healing drug as a control group, and the criteria were as follows:
the effect is shown: the adhesion degree of the medicine after being smeared is good, and the medicine is rarely scattered;
the method has the following advantages: the adhesion degree of the medicine after being smeared is general, and a small amount of medicine is left;
and (4) invalidation: the medicine is difficult to adhere after being smeared and is difficult to attach to the wound.
As can be seen from table 1, the wound healing drug prepared in example 2 is applied to a wound three times, and has high adhesion, i.e., high adhesion, so that the drug component can be effectively collided with the wound surface to accelerate wound healing, and then the wound is covered to prevent external bacteria from adhering to the wound surface to cause wound inflammation or lesion.
TABLE 1 evaluation of the degree of adhesion of wound healing drugs applied to wounds
| Group of | Number/name of display effect | Significant number/name | Invalid number/name | Significant efficiency/%) | Total effective rate/%) |
| Group 1 | 5 | 3 | 2 | 50 | 80 |
| 2 groups of | 7 | 3 | 0 | 70 | 100 |
| Group 3 | 6 | 1 | 3 | 60 | 70 |
| 4 groups of | - | - | - | - | - |
3. Healing effect of wound healing drugs
30 volunteers (18-25 years old) with non-healing or poor healing ability of the wound were selected and randomly and evenly divided into 3 groups of 10 persons, group 1 used the wound healing drug prepared in example 1, group 2 used the wound healing drug prepared in example 2, group 3 used the wound healing drug prepared in example 3, and the criteria were as follows:
the effect is shown: the scabbing is rapid, the scabbing and the falling blocks are formed, and the pain is obviously relieved;
the method has the following advantages: the scabbing is common, and the pain is relieved;
and (4) invalidation: the wound is not healed and the pain is still.
After each sample is used for two weeks, as can be seen from table 2, the wound healing medicament prepared in the embodiment 2 has obvious scabbing speed when being applied to a wound, obviously reduces the pain of most volunteers after being applied, has good use feeling, has high scabbing and falling speed after scabbing, and has good wound overall healing effect.
TABLE 2 evaluation of healing Effect of wound healing drugs
| Group of | Number/name of display effect | Significant number/name | Invalid number/name | Significant efficiency/%) | Total effective rate/%) |
| Group 1 | 3 | 5 | 2 | 30 | 80 |
| 2 groups of | 8 | 1 | 1 | 80 | 90 |
| Group 3 | 2 | 5 | 3 | 20 | 70 |
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and the preferred embodiments of the present invention are described in the above embodiments and the description, and are not intended to limit the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (3)
1. The preparation method of the wound healing medicine is characterized by comprising the following medicines by mass:
1-3 g of borneol, 1-4 g of sanguisorba officinalis, 2-4 g of rhubarb, 1-3 g of calcined oyster and 1-4 g of white granulated sugar;
the manufacturing method comprises the following steps:
1) selecting radix Sangusorbae, radix et rhizoma Rhei and Concha Ostreae preparata;
2) cleaning garden burnet, rhubarb and calcined oyster, and drying in the air after cleaning;
3) placing the dried garden burnet, rhubarb and calcined oyster shell in a high-temperature disinfection cabinet for disinfection treatment;
4) pulverizing sterilized radix Sangusorbae, radix et rhizoma Rhei, Concha Ostreae preparata, and white sugar in a pulverizer, decocting in a pot, removing water in a freeze-drying machine when decocting to viscous state, and pulverizing into powder after removing water;
5) mixing Borneolum Syntheticum and the powder to obtain the wound healing medicine.
2. The method for preparing a wound healing medicament according to claim 1, wherein the sterilization temperature in step 3) is one hundred degrees celsius and the sterilization duration is three minutes.
3. The method for preparing a drug for healing wound as claimed in claim 1, wherein the sterilizing manner of sanguisorba officinalis, rheum officinale and calcined oyster shell in step 3) is drying and sterilizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110442431.3A CN113509507A (en) | 2021-04-23 | 2021-04-23 | Wound healing medicine and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110442431.3A CN113509507A (en) | 2021-04-23 | 2021-04-23 | Wound healing medicine and preparation method thereof |
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| CN113509507A true CN113509507A (en) | 2021-10-19 |
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| CN202110442431.3A Pending CN113509507A (en) | 2021-04-23 | 2021-04-23 | Wound healing medicine and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716225A (en) * | 2011-06-20 | 2012-10-10 | 王长锋 | Externally dressed drug for treating burns and scalds |
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- 2021-04-23 CN CN202110442431.3A patent/CN113509507A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716225A (en) * | 2011-06-20 | 2012-10-10 | 王长锋 | Externally dressed drug for treating burns and scalds |
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