CN113476558A - Traditional Chinese medicine composition for treating Parkinson's disease, traditional Chinese medicine preparation and traditional Chinese medicine product - Google Patents
Traditional Chinese medicine composition for treating Parkinson's disease, traditional Chinese medicine preparation and traditional Chinese medicine product Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating Parkinson's disease, a traditional Chinese medicine preparation and a traditional Chinese medicine product. The invention provides a traditional Chinese medicine composition for treating Parkinson's disease, which comprises the following components: bombyx Batryticatus, radix Paeoniae alba, radix Polygoni Multiflori Preparata, radix scrophulariae, Corni fructus, radix rehmanniae Preparata, semen astragali Complanati, Poria, cortex moutan, Alismatis rhizoma, rhizoma Gastrodiae, ramulus Uncariae cum uncis, cortex Eucommiae, rhizoma anemarrhenae, Ecliptae herba, Haematitum, Concha Ostreae preparata, Saviae Miltiorrhizae radix, rhizoma Acori Graminei, Lumbricus, and Achyranthis radix. When the traditional Chinese medicine composition is used in combination, monarch, minister, assistant and guide compatibility is carried out, the traditional Chinese medicine composition can tonify kidney, benefit marrow, invigorate blood circulation, calm wind, lead qi and blood to have biochemical and active effects, can be used for preventing and treating the Parkinson's disease or the motor complications of the Parkinson's disease in a multi-way, multi-target and multi-level manner, is non-toxic, and has good application prospect.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition, a traditional Chinese medicine preparation and a traditional Chinese medicine product for treating Parkinson's disease.
Background
Parkinson's disease is a common nervous system degenerative disease of the elderly, which is mainly manifested by resting tremor, muscular rigidity, motor retardation and typical motor symptoms such as abnormal gait of posture, as well as sleep disorders such as difficulty in falling asleep, early awakening, fragmented sleep, restless legs syndrome, daytime sleepers, and the like; mental disorders such as depression, anxiety, cognitive disorders, hallucinations, apathy; autonomic dysfunction such as postural hypotension, hyperhidrosis, constipation, dysuria, salivation; sensory disorders such as numbness, pain, spasms, and the like. Parkinson's disease belongs to non-motor symptoms with complex clinical manifestations, high incidence, low recognition and large individual manifestation difference, the morbidity and the incidence of the Parkinson's disease increase by times with the increase of age, and the health and the life quality of middle-aged and old patients are seriously harmed.
At present, the Parkinson's disease is mainly focused on drug therapy and surgical therapy, the surgical therapy has certain indication and high cost, and the drug therapy is the main treatment method of the Parkinson's disease. The drug therapy of the Parkinson's disease such as the poly-baryonine tablet, the carbidopa controlled release tablet, the pramipexole hydrochloride tablet, the piribedil sustained release tablet, the entacapone tablet, the selegiline hydrochloride tablet and the like is generally used in clinic, but the current drug therapy has the problems of unsatisfactory curative effect, large motor fluctuation and side effect, poor curative effect on non-motor symptoms and the like.
Disclosure of Invention
The invention aims to solve the problems of unsatisfactory curative effect, motor fluctuation and large side effect of the prior art, and provides a traditional Chinese medicine composition, a traditional Chinese medicine preparation and a traditional Chinese medicine product for treating the Parkinson's disease.
In order to achieve the above object, the present invention provides a Chinese medicinal composition for treating parkinson's disease, which comprises the following components: bombyx Batryticatus, radix Paeoniae alba, radix Polygoni Multiflori Preparata, radix scrophulariae, Corni fructus, radix rehmanniae Preparata, semen astragali Complanati, Poria, cortex moutan, Alismatis rhizoma, rhizoma Gastrodiae, ramulus Uncariae cum uncis, cortex Eucommiae, rhizoma anemarrhenae, Ecliptae herba, Haematitum, Concha Ostreae preparata, Saviae Miltiorrhizae radix, rhizoma Acori Graminei, Lumbricus, and Achyranthis radix.
Preferably, the weight ratio of the white peony root to the stiff silkworm is 2-25 parts, the prepared fleece-flower root to the prepared stiff silkworm is 5-30 parts, the figwort root to the prepared cornus fruit to the wine is 5-30 parts, the prepared rehmannia root to the stiff silkworm is 5-30 parts, the poria cocos to the milkvetch seed to the prepared rehmannia root to the prepared fleece-flower root to the prepared rehmannia root to the stiff silkworm is 5-30 parts, the moutan bark to the prepared tree peony root to the prepared tree bark to the prepared common peony root to the prepared common macrocarpium to the prepared with the prepared rehmannia root to the medicinal composition of the stiff silkworm is 10-10 parts, the prepared milkvetch seed to the prepared rehmannia root to the honey-flower root to the honey flower root, 5-30 parts of salvia miltiorrhiza, 5-30 parts of rhizoma acori graminei, 2-20 parts of earthworm and 2-20 parts of achyranthes bidentata.
Preferably, the weight ratio of the white peony root to the stiff silkworm is 5-20 parts, the prepared fleece-flower root to the stiff silkworm is 10-20 parts, the figwort to the pulp of dogwood fruit to the wine to the pulp of 10-20 parts, the prepared rehmannia root to the pulp of 10-20 parts, the milkvetch seed to the flatstem milkvetch seed to the poria to the pulp of 10-15 parts, the moutan bark to the alisma to the pulp of 5-15 parts, the uncaria to the gambir plant to the salted eucommia to the saline eucommia to the salt to the eucommia to the pulp of 5-15 parts, the eclipta to the pulp of 10-20 parts, the ruddle to the calcined oyster to the stiff silkworm to the crude product to be processed fleece-flower fungus to be processed black bean product to be black, 10-20 parts of salvia miltiorrhiza, 10-20 parts of rhizoma acori graminei, 5-15 parts of earthworm and 5-15 parts of achyranthes bidentata.
The second aspect of the invention provides a preparation method of a traditional Chinese medicine preparation for treating Parkinson's disease, which comprises the following steps:
(1) pulverizing Saviae Miltiorrhizae radix, semen astragali Complanati, rhizoma Gastrodiae, radix Paeoniae alba, radix scrophulariae, and Poria, and sieving to obtain mixed fine powder and mixed coarse residue;
(2) mixing Bombyx Batryticatus, radix Polygoni Multiflori Preparata, Corni fructus (processed with wine), radix rehmanniae Preparata, cortex moutan, Alismatis rhizoma, ramulus Uncariae cum uncis, cortex Eucommiae (processed with salt), rhizoma anemarrhenae, Ecliptae herba, Haematitum, Concha Ostreae preparata, rhizoma Acori Graminei, Lumbricus, Achyranthis radix, and the mixed coarse residue obtained in step (1) with water, decocting, filtering to obtain water extract, and concentrating under reduced pressure to obtain extract;
(3) and (3) mixing the mixed fine powder obtained in the step (1) with the extract obtained in the step (2), adding pharmaceutically acceptable auxiliary materials and/or drying to obtain the traditional Chinese medicine preparation for treating the Parkinson's disease.
Preferably, the weight portion of the stiff silkworm is 10 parts, the white paeony root is 2-25 parts, the prepared fleece-flower root is 5-30 parts, the figwort root is 5-30 parts, the cornus officinalis processed with wine is 5-30 parts, the prepared rehmannia root is 5-30 parts, the flastem milkvetch seed is 5-30 parts, the poria cocos is 5-30 parts, the moutan bark is 2-20 parts, the alisma orientale is 2-20 parts, the gastrodia elata is 2-20 parts, the uncaria is 5-30 parts, the salted eucommia ulmoides is 2-20 parts, the rhizoma anemarrhenae is 2-20 parts, the eclipta alba is 5-30 parts, the ruddle is 10-50 parts, the calcined oyster shell is 10-50 parts, the white paeony root is 5-30 parts, the tuber fleeceflower root is 5-30 parts, the rhizome of common anemarrhena is 2-20 parts, the eclipta is 5-30 parts, the ruddle is 10-50 parts, the oyster shell is 10-50 parts, 5-30 parts of salvia miltiorrhiza, 5-30 parts of rhizoma acori graminei, 2-20 parts of earthworm and 2-20 parts of achyranthes bidentata;
preferably, the weight of the white peony root is 5-20 parts, the weight of the prepared fleece-flower root is 10-20 parts, the weight of the figwort is 10-20 parts, the weight of the cornus officinalis processed with wine is 10-20 parts, the weight of the prepared rehmannia root is 10-20 parts, the weight of the flastem milkvetch seed is 10-20 parts, the weight of the poria cocos is 10-20 parts, the weight of the moutan bark is 5-15 parts, the weight of the alisma orientale is 5-15 parts, the weight of the gastrodia elata is 5-15 parts, the weight of the uncaria rhynchophylla is 10-20 parts, the weight of the salted eucommia ulmoides is 5-15 parts, the weight of the anemarrhena rhizome is 5-15 parts, the weight of the eclipta alba is 10-20 parts, the weight of the ruddle is 25-35 parts, the weight of the calcined oyster shell is 25-35 parts, the weight of the white peony root is 10-20 parts, the radix scrophulariae, the cornus officinalis is 10-20 parts, the astragalus mongholicus and the white peony root are 10-20 parts, The dosage of the salvia miltiorrhiza is 10 to 20 weight portions, the dosage of the grassleaf sweelflag rhizome is 10 to 20 weight portions, the dosage of the earthworm is 5 to 15 weight portions, and the dosage of the twotooth achyranthes root is 5 to 15 weight portions.
Preferably, the sieving screen in the step (1) is a 150-200-mesh screen, and the filtering in the step (2) adopts a 100-200-mesh screen.
Preferably, the decocting times in step (2) are 2-4 times, and filtrates obtained by filtering after each decocting are combined to obtain the water extract; in each decocting process, the weight ratio of the total weight of the traditional Chinese medicine raw materials to water is 1: 3-8, wherein the decocting at least meets the following conditions: the decocting temperature is 100-.
Preferably, the density of the extract in the step (2) at the temperature of 50 ℃ is 1.15-1.25 g/mL.
In a third aspect, the present invention provides a Chinese medicinal preparation prepared by the above preparation method.
The invention provides a traditional Chinese medicine product for treating Parkinson's disease, which contains the traditional Chinese medicine composition or the traditional Chinese medicine preparation prepared by the preparation method.
Through the technical scheme, the invention has the beneficial effects that:
the traditional Chinese medicine composition for treating the Parkinson disease provided by the invention is scientific and excellent in formula, and the stiff silkworm has the effects of calming endogenous wind and relieving spasm, dispelling wind and relieving pain, and reducing phlegm and resolving masses and is a monarch drug; the radix paeoniae alba nourishes blood and regulates menstruation, the prepared polygonum multiflorum has the effects of nourishing liver and kidney and benefiting essence and blood, the radix scrophulariae has the effects of clearing heat and cooling blood, nourishing yin and lowering fire, the cornus wine has the effects of tonifying liver and kidney and controlling nocturnal emission and relieving depletion, and the three are used as ministerial medicines for nourishing liver and kidney and benefiting essence and blood to strengthen the body resistance; prepared rehmannia root is used for nourishing yin and blood, flatstem milkvetch seed is used for tonifying liver and kidney, improving eyesight and securing essence, poria cocos is used for promoting diuresis and excreting dampness, tonifying spleen and calming heart, cortex moutan is used for clearing heat and cooling blood, activating blood and dissolving stasis and removing deficiency heat, rhizoma alismatis is used for promoting diuresis and excreting dampness, clearing heat, dissolving turbidity and reducing fat, rhizoma gastrodiae is used for calming wind and relieving convulsion, dispelling wind and dredging collaterals, uncaria is used for calming wind and arresting convulsion, clearing heat and calming liver, cortex eucommiae is used for tonifying liver and kidney, strengthening bones and muscles, rhizoma anemarrhenae is used for clearing heat and purging fire, nourishing yin and moistening dryness, eclipta is used for nourishing liver and kidney, ruddle is used for calming liver and calming the adverse-rising energy, calcined oyster is used for tranquilization, salvia miltiorrhiza is used for activating blood and dissolving stasis, clearing heart and relieving restlessness, rhizoma acori graminei is used for resolving dampness and stimulating appetite, and refreshing mind and promoting intelligence; the earthworm is used for clearing heat, arresting convulsion, dredging collaterals, and the achyranthes root is used for removing blood stasis, stimulating the menstrual flow, tonifying liver and kidney, and strengthening bones and muscles; the traditional Chinese medicine composition has the effects of tonifying kidney, benefiting marrow, dredging collaterals and calming endogenous wind by combining various medicines. The composition has the effects of combining tonification and purgation, treating both principal and secondary aspects, dredging collaterals and calming endogenous wind without damaging essence and blood, tonifying essence and blood without nourishing, greasiness and congestion, orderly ascending and descending of qi activity, uniformly regulating qi and blood, and dredging collaterals and dispelling wind, can prevent and treat the Parkinson's disease or the motion complications of the Parkinson's disease in a multi-way, multi-target and multi-layer manner, has no toxicity, and has good application prospect.
The preparation method of the traditional Chinese medicine preparation for treating the Parkinson's disease provided by the invention is simple in process, is more beneficial to preparing the medicine for treating the Parkinson's disease, and can effectively reduce the production cost of the medicine.
Detailed Description
The endpoints of the ranges and any values disclosed herein are not limited to the precise range or value, and such ranges or values should be understood to encompass values close to those ranges or values. For ranges of values, between the endpoints of each of the ranges and the individual points, and between the individual points may be combined with each other to give one or more new ranges of values, and these ranges of values should be considered as specifically disclosed herein.
The invention provides a traditional Chinese medicine composition for treating Parkinson's disease, which comprises the following components: bombyx Batryticatus, radix Paeoniae alba, radix Polygoni Multiflori Preparata, radix scrophulariae, Corni fructus, radix rehmanniae Preparata, semen astragali Complanati, Poria, cortex moutan, Alismatis rhizoma, rhizoma Gastrodiae, ramulus Uncariae cum uncis, cortex Eucommiae, rhizoma anemarrhenae, Ecliptae herba, Haematitum, Concha Ostreae preparata, Saviae Miltiorrhizae radix, rhizoma Acori Graminei, Lumbricus, and Achyranthis radix.
The pharmacological analysis of the selected raw materials of the invention is as follows:
stiff silkworm: is a dry body which is lethal when larva of silkworm of bombyx mori of Bombycidae is infected with Beauveria bassiana (Bals.) Vuillant, and has effects of calming endogenous wind, relieving spasm, dispelling pathogenic wind, relieving pain, eliminating phlegm and resolving hard mass;
white peony root: is a plant of the genus Anemone of the family Asclepiadaceae, medicinal root, pungent and bitter in taste and warm in nature, and has the effects of warming yang, eliminating dampness, supplementing deficiency, strengthening spleen and stomach and the like;
preparing fleece-flower root: brown or black, light smell, slightly sweet and bitter taste, and has effects of nourishing liver and kidney, replenishing essence and blood, blackening hair and beard, and strengthening tendons and bones;
figwort root: is a Scrophulariaceae herbaceous plant, is sweet, bitter, salty and slightly cold in nature, and has the effects of clearing heat and cooling blood, nourishing yin and lowering fire, and detoxifying and resolving masses;
alcohol cornus: dried mature pulp of Corni fructus of Cornaceae is sour, astringent and slightly warm, and has effects of invigorating liver and kidney, and arresting seminal emission;
prepared rehmannia root: the rhizome of Scrophulariaceae plant rehmanniae or HUAIQINGDIHUANG is processed by steaming and sun drying, has sweet and mild taste, and has effects of nourishing yin and replenishing blood;
flatstem milkvetch seed: the seeds of Astragalus platyphylla bge or Astragalus membranaceus bge of Leguminosae are sweet and slightly warm in taste, and have the effects of nourishing liver, tonifying kidney, improving eyesight and stopping nocturnal emission;
tuckahoe, poria cocos: dried sclerotium of Poria cocos (Schw.) wolf of Polyporaceae family, sweet and light in taste, neutral in nature, and has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart;
moutan bark: the Paeonia suffruticosa Andr.f. of Ranunculaceae has bitter, pungent and slightly cold dry root bark, and has effects of clearing heat and cooling blood, promoting blood circulation for removing blood stasis, and eliminating asthenic fever;
rhizoma alismatis: dried tuber of Alisma orientale of Alismaceae has sweet and light taste and cold property, and has effects of promoting diuresis, eliminating dampness, clearing heat, eliminating turbid pathogen and reducing blood lipid;
gastrodia elata: dried tuber of Gastrodia elata Blume of Orchidaceae, sweet in taste and neutral in nature, has effects of calming endogenous wind and relieving spasm, suppressing liver yang, dispelling pathogenic wind and dredging collaterals;
uncaria: dried stem branches with hooks of Uncaria rhynchophylla, Uncaria macrophylla, Uncaria tomentosa, Uncaria huashanensis or Uncaria canescens of Rubiaceae, are sweet in taste and cool in nature, and have the effects of calming endogenous wind, arresting convulsion, clearing heat and calming liver;
salt eucommia bark: the eucommia bark is fried by salt, is sweet, slightly pungent and warm in taste, and has the effects of nourishing liver and kidney and strengthening tendons and bones;
rhizoma anemarrhenae: dried rhizome of Anemarrhena asphodeloides Bunge of Liliaceae family, with bitter and cold properties, has effects of clearing heat-fire, nourishing yin and moistening dryness;
and (3) eclipta: dried aerial parts of eclipta of Compositae, sweet, sour and cold in nature, and has effects of nourishing liver and kidney, cooling blood and stopping bleeding;
haematitum: the oxidized corundum mineral hematite ore is bitter, sweet and slightly cold in nature, and has the effects of calming the liver, suppressing yang hyperactivity, seriously relieving the adverse flow of qi, cooling blood and stopping bleeding;
calcining oysters: has astringent, antacid, analgesic, tranquilizing, and hard mass softening and resolving effects;
red sage root: dried root and rhizome of Salvia miltiorrhiza Bunge of Labiatae, with bitter and slightly cold taste, has effects of promoting blood circulation for removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood and resolving carbuncle;
grassleaf sweelflag rhizome: has effects in eliminating dampness, stimulating appetite, inducing resuscitation, eliminating phlegm, refreshing mind, and improving intelligence;
earthworm: has effects in clearing away heat, arresting convulsion, expelling collateral obstruction, relieving asthma, and promoting urination;
achyranthes root: the dried root of achyranthes bidentata of Amaranthaceae is bitter, sweet, sour and mild in taste, and has the effects of removing blood stasis, dredging channels, nourishing liver and kidney, strengthening tendons and bones, inducing diuresis, treating stranguria and inducing blood circulation.
The traditional Chinese medicine composition is unique and reasonable in compatibility, and the combination of the raw materials can tonify kidney and benefit marrow, dredge collaterals and extinguish wind, can effectively improve the motor symptoms and non-motor symptoms of a Parkinson disease patient, and can improve the immunity of the patient. After repeated research and optimization, the traditional Chinese medicine composition provided by the invention has good effect when being applied to clinical practice, and has remarkable effect on treating the Parkinson's disease.
Preferably, the weight ratio of the white peony root to the stiff silkworm is 2-25 parts, the prepared fleece-flower root to the prepared stiff silkworm is 5-30 parts, the figwort root to the prepared cornus fruit to the wine is 5-30 parts, the prepared rehmannia root to the stiff silkworm is 5-30 parts, the poria cocos to the milkvetch seed to the prepared rehmannia root to the prepared fleece-flower root to the prepared rehmannia root to the stiff silkworm is 5-30 parts, the moutan bark to the prepared tree peony root to the prepared tree bark to the prepared common peony root to the prepared common macrocarpium to the prepared with the prepared rehmannia root to the medicinal composition of the stiff silkworm is 10-10 parts, the prepared milkvetch seed to the prepared rehmannia root to the honey-flower root to the honey flower root, 5-30 parts of salvia miltiorrhiza, 5-30 parts of rhizoma acori graminei, 2-20 parts of earthworm and 2-20 parts of achyranthes bidentata. According to the conditions of constitution, disease symptoms and the like of patients, the raw materials of each traditional Chinese medicine can be adjusted within the given part range, and proper numerical values are taken to achieve the best treatment effect.
More preferably, the weight ratio of the white peony root to the stiff silkworm is 5-20 parts, the prepared fleece-flower root to the prepared stiff silkworm is 10-20 parts, the figwort to the figwort root to the prepared figwort root to the pulp of 10-20 parts, the dogwood fruit to the wine to the pulp of 10-20 parts, the prepared rehmannia root to the flatstem milkvetch seed to the prepared fleece-flower root to the pulp of 10-20 parts, the tree peony bark to the prepared tree peony root to the pulp of 5-15 parts, the oriental waterplantain rhizome to the prepared common yam rhizome to the pulp of 5-15 parts, the tall gastrodia tuber to the prepared tall gastrodia tuber to the pulp of 10-20 parts, the gambir plant to the prepared stiff silkworm to the 10-20 parts, the tall gastrodia tuber to the prepared common anemarrhena rhizome to the prepared rehmannia root to the prepared tall gastrodia tuber of 10-35 parts, the stiff silkworm to the prepared common anemarrhena root to the prepared common anemarrhena rhizome to the prepared common anemarrhena root to the prepared common anemarrhena rhizome to the prepared common mulberry root to the dried herb to the dried hawkthodeloides to the dried mixture to the dried oyster to the dried mixture to the dried stiff silkworm to the dried mixture to the dried stiff silkworm mixture to the dried stiff silkworm mixture to the dried stiff silkworm mixture to the stiff silkworm, 10-20 parts of salvia miltiorrhiza, 10-20 parts of rhizoma acori graminei, 5-15 parts of earthworm and 5-15 parts of achyranthes bidentata.
The second aspect of the invention provides a preparation method of a traditional Chinese medicine preparation for treating Parkinson's disease, which comprises the following steps:
(1) pulverizing Saviae Miltiorrhizae radix, semen astragali Complanati, rhizoma Gastrodiae, radix Paeoniae alba, radix scrophulariae, and Poria, and sieving to obtain mixed fine powder and mixed coarse residue;
(2) mixing Bombyx Batryticatus, radix Polygoni Multiflori Preparata, Corni fructus (processed with wine), radix rehmanniae Preparata, cortex moutan, Alismatis rhizoma, ramulus Uncariae cum uncis, cortex Eucommiae (processed with salt), rhizoma anemarrhenae, Ecliptae herba, Haematitum, Concha Ostreae preparata, rhizoma Acori Graminei, Lumbricus, Achyranthis radix, and the mixed coarse residue obtained in step (1) with water, decocting, filtering to obtain water extract, and concentrating under reduced pressure to obtain extract;
(3) and (3) mixing the mixed fine powder obtained in the step (1) with the extract obtained in the step (2), adding pharmaceutically acceptable auxiliary materials and/or drying to obtain the traditional Chinese medicine preparation for treating the Parkinson's disease.
The invention has no special limitation on the crushing, decocting, filtering and concentrating modes and equipment, the filtering can be performed by filter pressing, suction filtration or other modes, and the concentrating can be performed by a concentrating tank or any other concentrating equipment.
Preferably, the weight portion of the stiff silkworm is 10 parts, the white paeony root is 2-25 parts, the prepared fleece-flower root is 5-30 parts, the figwort root is 5-30 parts, the cornus officinalis processed with wine is 5-30 parts, the prepared rehmannia root is 5-30 parts, the flastem milkvetch seed is 5-30 parts, the poria cocos is 5-30 parts, the moutan bark is 2-20 parts, the alisma orientale is 2-20 parts, the gastrodia elata is 2-20 parts, the uncaria is 5-30 parts, the salted eucommia ulmoides is 2-20 parts, the rhizoma anemarrhenae is 2-20 parts, the eclipta alba is 5-30 parts, the ruddle is 10-50 parts, the calcined oyster shell is 10-50 parts, the white paeony root is 5-30 parts, the tuber fleeceflower root is 5-30 parts, the rhizome of common anemarrhena is 2-20 parts, the eclipta is 5-30 parts, the ruddle is 10-50 parts, the oyster shell is 10-50 parts, 5-30 parts of salvia miltiorrhiza, 5-30 parts of rhizoma acori graminei, 2-20 parts of earthworm and 2-20 parts of achyranthes bidentata;
more preferably, the weight of the white peony root is 5-20 parts, the weight of the prepared fleece-flower root is 10-20 parts, the weight of the figwort is 10-20 parts, the weight of the dogwood fruit processed with wine is 10-20 parts, the weight of the prepared rehmannia root is 10-20 parts, the weight of the flastem milkvetch seed is 10-20 parts, the weight of the tuckahoe is 10-20 parts, the weight of the moutan bark is 5-15 parts, the weight of the alisma orientale is 5-15 parts, the weight of the gastrodia elata is 5-15 parts, the weight of the uncaria rhynchophylla is 10-20 parts, the weight of the salted eucommia ulmoides is 5-15 parts, the weight of the rhizoma anemarrhenae is 5-15 parts, the weight of the yerbadetajo herba ecliptae is 10-20 parts, the weight of the ruddle is 25-35 parts, the weight of the calcined oyster shell is 25-35 parts, the weight of the white peony root is 10-20 parts, the radix scrophulariae is 10-15 parts, the rhizoma alismatis is 5-15 parts, the rhizoma atractylodis is 5-35 parts, the white atractylodes rhizome is 10-20 parts, the white peony root is 10-35 parts, the root is 10-20 parts, the root is the root of the white mulberry is the white mulberry root, the white mulberry root is the white mulberry root, the white mulberry root, The dosage of the salvia miltiorrhiza is 10 to 20 weight portions, the dosage of the grassleaf sweelflag rhizome is 10 to 20 weight portions, the dosage of the earthworm is 5 to 15 weight portions, and the dosage of the twotooth achyranthes root is 5 to 15 weight portions.
According to the invention, the sieving screen in the step (1) is a 150-200-mesh sieve, and the filtering screen in the step (2) is a 100-200-mesh sieve.
According to the invention, the decocting times in the step (2) are 2-4 times, and filtrates obtained by filtering after each decocting are combined to obtain the water extract; in each decocting process, the weight ratio of the total weight of the traditional Chinese medicine raw materials to water is 1: 3-8, wherein the decocting at least meets the following conditions: the decocting temperature is 100-; the decoction time is 1-4h, specifically 1h, 2h, 3h, 4h, or any value between any two of the above values. The inventors found that, in the preferred embodiment, the scheme of the invention has the effect of further improving the extraction efficiency of the effective components in each raw material.
According to the invention, the density of the extract in the step (2) at the temperature of 50 ℃ is 1.15-1.25 g/mL. The preferred embodiment increases the density of the Chinese medicinal composition through the concentration process, is beneficial to reducing the dosage of patients, and is convenient for packaging and transportation.
In a third aspect, the present invention provides a Chinese medicinal preparation prepared by the above preparation method.
The invention provides a traditional Chinese medicine product for treating Parkinson's disease, which contains the traditional Chinese medicine composition or the traditional Chinese medicine preparation prepared by the preparation method.
Preferably, the dosage form of the traditional Chinese medicine product is soft extract, decoction, mixture, oral liquid, granules, pills, tablets and capsules. The traditional Chinese medicine product is prepared into a soft extract, a decoction, a mixture, an oral liquid, granules, pills, tablets and capsules by using the traditional Chinese medicine composition or the traditional Chinese medicine preparation and adding conventional auxiliary materials.
The present invention will be described in detail below by way of examples.
In the following examples, the contents of dopamine and homovanillic acid were measured by high performance liquid chromatography; bombyx Batryticatus, radix Paeoniae alba, radix Polygoni Multiflori Preparata, radix scrophulariae, Corni fructus, radix rehmanniae Preparata, semen astragali Complanati, Poria, cortex moutan, Alismatis rhizoma, rhizoma Gastrodiae, ramulus Uncariae cum uncis, salted Eucommiae cortex, rhizoma anemarrhenae, Ecliptae herba, Haematitum, Concha Ostreae preparata, Saviae Miltiorrhizae radix, rhizoma Acori Graminei, Lumbricus, and Achyranthis radix are all conventional products.
Example 1
(1) Pulverizing 150g of Saviae Miltiorrhizae radix, 150g of semen astragali Complanati, 100g of rhizoma Gastrodiae, 120g of radix Paeoniae alba, 150g of radix scrophulariae, and 150g of Poria, and sieving with 175 mesh sieve to obtain mixed fine powder passing through the mesh sieve and mixed coarse residue intercepted by the mesh sieve;
(2) mixing 100g of stiff silkworm, 150g of prepared fleece-flower root, 150g of wine cornus, 150g of prepared rehmannia root, 90g of tree peony bark, 90g of rhizoma alismatis, 150g of uncaria, 100g of salted eucommia bark, 100g of rhizoma anemarrhenae, 150g of eclipta, 300g of ruddle, 300g of calcined oyster shell, 150g of rhizoma acori graminei, 100g of earthworm and 100g of radix achyranthis bidentatae and the mixed coarse residue obtained in the step (1) to obtain a mixture, adding water which is 5 times of the total amount of the mixture, decocting for 3 hours at the temperature of 110 ℃, and filtering by a 150-mesh screen to obtain a first filtrate and a first residue; adding 5 times of water into the first residue, decocting at 110 deg.C for 2 hr, and filtering with 150 mesh sieve to obtain second filtrate and second residue; adding 5 times of water into the second residue, decocting at 110 deg.C for 2 hr, filtering with 150 mesh sieve to obtain third filtrate, mixing the three filtrates to obtain water extract, and concentrating under reduced pressure to obtain extract with density of 1.2g/mL at 50 deg.C;
(3) and (3) mixing the mixed fine powder obtained in the step (1) with the extract obtained in the step (2) to obtain the traditional Chinese medicine extract product for treating the Parkinson disease.
Example 2
(1) Pulverizing 200g of Saviae Miltiorrhizae radix, 200g of semen astragali Complanati, 150g of rhizoma Gastrodiae, 200g of radix Paeoniae alba, 200g of radix scrophulariae, and 200g of Poria, and sieving with 150 mesh sieve to obtain mixed fine powder passing through the mesh sieve and mixed coarse residue intercepted by the mesh sieve;
(2) mixing 100g of stiff silkworm, 200g of prepared fleece-flower root, 200g of wine cornus, 200g of prepared rehmannia root, 150g of tree peony bark, 150g of rhizoma alismatis, 200g of uncaria, 150g of salted eucommia bark, 150g of rhizoma anemarrhenae, 200g of eclipta, 350g of ruddle, 350g of calcined oyster shell, 200g of rhizoma acori graminei, 150g of earthworm and 150g of radix achyranthis bidentatae and the mixed coarse residue obtained in the step (1) to obtain a mixture, adding water with the amount being 8 times of the total amount of the mixture, decocting for 4 hours at the temperature of 120 ℃, and filtering by a 100-mesh screen to obtain a first filtrate and a first residue; adding 6 times of water into the first residue, decocting at 120 deg.C for 2 hr, filtering with 100 mesh screen to obtain second filtrate, mixing the filtrates to obtain water extract, and concentrating under reduced pressure to obtain extract with density of 1.25g/mL at 50 deg.C;
(3) and (3) mixing the mixed fine powder obtained in the step (1) with the extract obtained in the step (2) to obtain the traditional Chinese medicine extract product for treating the Parkinson disease.
Example 3
(1) Pulverizing 100g of Saviae Miltiorrhizae radix, 100g of semen astragali Complanati, 50g of rhizoma Gastrodiae, 50g of radix Paeoniae alba, 100g of radix scrophulariae, and 100g of Poria, and sieving with 200 mesh sieve to obtain mixed fine powder passing through the mesh sieve and mixed coarse residue intercepted by the mesh sieve;
(2) mixing 100g of stiff silkworm, 100g of prepared fleece-flower root, 100g of wine cornus, 100g of prepared rehmannia root, 50g of tree peony bark, 50g of rhizoma alismatis, 100g of uncaria, 50g of salted eucommia bark, 50g of rhizoma anemarrhenae, 100g of eclipta, 250g of ruddle, 250g of calcined oyster shell, 100g of rhizoma acori graminei, 50g of earthworm and 50g of radix achyranthis bidentatae and the mixed coarse residue obtained in the step (1) to obtain a mixture, adding water in an amount which is 6 times of the total amount of the mixture, decocting for 4 hours at the temperature of 100 ℃, and filtering by a 200-mesh screen to obtain a first filtrate and a first residue; adding 5 times of water into the first residue, decocting at 100 deg.C for 3 hr, and filtering with 200 mesh sieve to obtain second filtrate and second residue; adding 3 times of water into the second residue, decocting at 100 deg.C for 2 hr, and filtering with 200 mesh sieve to obtain third filtrate and third residue; adding 3 times of water into the third residue, decocting at 100 deg.C for 1 hr, filtering with 200 mesh sieve to obtain fourth filtrate, mixing the filtrates to obtain water extract, and concentrating under reduced pressure to obtain extract with density of 1.15g/mL at 50 deg.C;
(3) and (3) mixing the mixed fine powder obtained in the step (1) with the extract obtained in the step (2) to obtain the traditional Chinese medicine extract product for treating the Parkinson disease.
Example 4
(1) Pulverizing 300g of Saviae Miltiorrhizae radix, 300g of semen astragali Complanati, 200g of rhizoma Gastrodiae, 250g of radix Paeoniae alba, 300g of radix scrophulariae, and 300g of Poria, and sieving with 150 mesh sieve to obtain mixed fine powder passing through the mesh sieve and mixed coarse residue intercepted by the mesh sieve;
(2) mixing 100g of stiff silkworm, 300g of prepared fleece-flower root, 300g of wine cornus, 300g of prepared rehmannia root, 200g of tree peony bark, 200g of rhizoma alismatis, 300g of uncaria, 200g of salted eucommia bark, 200g of rhizoma anemarrhenae, 300g of eclipta, 500g of ruddle, 500g of calcined oyster shell, 300g of rhizoma acori graminei, 200g of earthworm and 200g of radix achyranthis bidentatae and the mixed coarse residue obtained in the step (1) to obtain a mixture, adding 8 times of water of the total amount of the mixture, decocting for 4 hours at the temperature of 120 ℃, and filtering by a 100-mesh screen to obtain a first filtrate and a first residue; adding 6 times of water into the first residue, decocting at 120 deg.C for 2 hr, filtering with 100 mesh screen to obtain second filtrate, mixing the filtrates to obtain water extract, and concentrating under reduced pressure to obtain extract with density of 1.25g/mL at 50 deg.C;
(3) and (3) mixing the mixed fine powder obtained in the step (1) with the extract obtained in the step (2) to obtain the traditional Chinese medicine extract product for treating the Parkinson disease.
Example 5
(1) Pulverizing 50g of Saviae Miltiorrhizae radix, 50g of semen astragali Complanati, 20g of rhizoma Gastrodiae, 20g of radix Paeoniae alba, 50g of radix scrophulariae, and 50g of Poria, and sieving with 200 mesh sieve to obtain mixed fine powder passing through the mesh sieve and mixed coarse residue intercepted by the mesh sieve;
(2) mixing 100g of stiff silkworm, 50g of prepared fleece-flower root, 50g of wine cornus, 50g of prepared rehmannia root, 20g of tree peony bark, 20g of rhizoma alismatis, 50g of uncaria, 20g of salted eucommia bark, 20g of rhizoma anemarrhenae, 50g of eclipta, 100g of ruddle, 100g of calcined oyster shell, 50g of rhizoma acori graminei, 20g of earthworm and 20g of radix achyranthis bidentatae and the mixed coarse residue obtained in the step (1) to obtain a mixture, adding water in an amount which is 6 times of the total amount of the mixture, decocting for 4 hours at the temperature of 100 ℃, and filtering by a 200-mesh screen to obtain a first filtrate and a first residue; adding 5 times of water into the first residue, decocting at 100 deg.C for 3 hr, and filtering with 200 mesh sieve to obtain second filtrate and second residue; adding 3 times of water into the second residue, decocting at 100 deg.C for 2 hr, filtering with 200 mesh sieve to obtain third filtrate, mixing the three filtrates to obtain water extract, and concentrating under reduced pressure to obtain extract with density of 1.15g/mL at 50 deg.C;
(3) and (3) mixing the mixed fine powder obtained in the step (1) with the extract obtained in the step (2) to obtain the traditional Chinese medicine extract product for treating the Parkinson disease.
Example 6
(1) Pulverizing 100g of Saviae Miltiorrhizae radix, 20g of semen astragali Complanati, 50g of rhizoma Gastrodiae, 50g of radix Paeoniae alba, 100g of radix scrophulariae, and 100g of Poria, and sieving with 200 mesh sieve to obtain mixed fine powder passing through the mesh sieve and mixed coarse residue intercepted by the mesh sieve;
(2) mixing 100g of stiff silkworm, 100g of prepared fleece-flower root, 100g of wine cornus, 100g of prepared rehmannia root, 350g of tree peony bark, 50g of rhizoma alismatis, 100g of uncaria, 50g of salted eucommia bark, 50g of rhizoma anemarrhenae, 350g of eclipta, 50g of ruddle, 50g of calcined oyster shell, 100g of rhizoma acori graminei, 50g of earthworm and 50g of radix achyranthis bidentatae and the mixed coarse residue obtained in the step (1) to obtain a mixture, adding water in an amount which is 6 times of the total amount of the mixture, decocting for 4 hours at the temperature of 100 ℃, and filtering by a 200-mesh screen to obtain a first filtrate and a first residue; adding 5 times of water into the first residue, decocting at 100 deg.C for 3 hr, and filtering with 200 mesh sieve to obtain second filtrate and second residue; adding 3 times of water into the second residue, decocting at 100 deg.C for 2 hr, filtering with 200 mesh sieve to obtain third filtrate, mixing the three filtrates to obtain water extract, and concentrating under reduced pressure to obtain extract with density of 1.2g/mL at 50 deg.C;
(3) and (3) mixing the mixed fine powder obtained in the step (1) and the extract obtained in the step (2), adding auxiliary materials such as starch and the like in a conventional amount, uniformly mixing, and making pills to obtain the traditional Chinese medicine pill product for treating the Parkinson's disease.
Comparative example 1
(1) Pulverizing 100g of Saviae Miltiorrhizae radix, 50g of rhizoma Gastrodiae, 50g of radix Paeoniae alba, 100g of radix scrophulariae, and 100g of Poria, and sieving with 200 mesh sieve to obtain mixed fine powder passing through the mesh sieve and mixed coarse residue intercepted by the mesh sieve;
(2) mixing 100g of stiff silkworm, 100g of prepared fleece-flower root, 100g of wine cornus, 100g of prepared rehmannia root, 50g of rhizoma alismatis, 100g of uncaria, 50g of salted eucommia bark, 50g of rhizoma anemarrhenae, 100g of rhizoma acori graminei, 50g of earthworm and 50g of achyranthes bidentata and the mixed coarse residue obtained in the step (1) to obtain a mixture, adding water in an amount which is 6 times of the total amount of the mixture, decocting for 4 hours at the temperature of 100 ℃, and filtering by using a 200-mesh screen to obtain a first filtrate and a first residue; adding 5 times of water into the first residue, decocting at 100 deg.C for 3 hr, and filtering with 200 mesh sieve to obtain second filtrate and second residue; adding 3 times of water into the second residue, decocting at 100 deg.C for 2 hr, and filtering with 200 mesh sieve to obtain third filtrate and third residue; adding 3 times of water into the third residue, decocting at 100 deg.C for 1 hr, filtering with 200 mesh sieve to obtain fourth filtrate, mixing the filtrates to obtain water extract, and concentrating under reduced pressure to obtain extract with density of 1.15g/mL at 50 deg.C;
(3) and (3) mixing the mixed fine powder obtained in the step (1) with the extract obtained in the step (2) to obtain the traditional Chinese medicine extract product for treating the Parkinson disease.
Comparative example 2
(1) Pulverizing 100g of Saviae Miltiorrhizae radix, 100g of semen astragali Complanati, 50g of rhizoma Gastrodiae, 50g of radix Paeoniae alba, and 100g of Poria, and sieving with 200 mesh sieve to obtain mixed fine powder passing through the mesh sieve and mixed coarse residue intercepted by the mesh sieve;
(2) mixing 100g of stiff silkworm, 100g of wine cornus, 100g of caulis clematidis armandii, 100g of angelica, 100g of prepared rehmannia root, 50g of moutan bark, 50g of rhizoma alismatis, 100g of uncaria, 50g of liquorice, 50g of rhizoma anemarrhenae, 100g of eclipta, 250g of ruddle, 250g of calcined oyster shell, 100g of rhizoma acori graminei, 50g of earthworm and 50g of achyranthes and the mixed coarse residue obtained in the step (1) to obtain a mixture, adding water with the amount of 6 times of the total amount of the mixture, decocting for 4 hours at the temperature of 100 ℃, and filtering by a 200-mesh screen to obtain a first filtrate and a first residue; adding 5 times of water into the first residue, decocting at 100 deg.C for 3 hr, and filtering with 200 mesh sieve to obtain second filtrate and second residue; adding 3 times of water into the second residue, decocting at 100 deg.C for 2 hr, and filtering with 200 mesh sieve to obtain third filtrate and third residue; adding 3 times of water into the third residue, decocting at 100 deg.C for 1 hr, filtering with 200 mesh sieve to obtain fourth filtrate, mixing the filtrates to obtain water extract, and concentrating under reduced pressure to obtain extract with density of 1.15g/mL at 50 deg.C;
(3) and (3) mixing the mixed fine powder obtained in the step (1) with the extract obtained in the step (2) to obtain the traditional Chinese medicine extract product for treating the Parkinson disease.
Comparative example 3
(1) Crushing 50g of white paeony root, 100g of prepared fleece-flower root, 100g of figwort root, 100g of prepared rehmannia root, 100g of tuckahoe, 250g of ruddle, 250g of calcined oyster shell, 100g of stiff silkworm, 100g of wine cornus, 100g of flatstem milkvetch seed, 50g of tree peony bark, 50g of rhizoma alismatis, 50g of rhizoma gastrodiae, 100g of uncaria, 50g of salted eucommia bark, 50g of rhizoma anemarrhenae, 100g of eclipta, 100g of salvia miltiorrhiza, 100g of rhizoma acori graminei, 50g of earthworm and 50g of achyranthes bidentata, mixing to obtain a mixture, adding water with the amount being 6 times of the total amount of the mixture, decocting for 4 hours at the temperature of 105 ℃, and filtering by a 200-mesh screen to obtain a first filtrate and a first decoction residue; adding 5 times of water into the first residue, decocting at 105 deg.C for 3 hr, and filtering with 200 mesh sieve to obtain second filtrate and second residue; adding 4 times of water into the second residue, decocting at 105 deg.C for 2 hr, filtering with 200 mesh sieve to obtain third filtrate, and mixing the third filtrates to obtain water extract;
(2) concentrating the water extract under reduced pressure to obtain extract with density of 1.15g/mL at 50 deg.C to obtain traditional Chinese medicine extract product for treating Parkinson disease.
Test example 1
1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is adopted to induce the damage of black dopamine neurons of SPF grade C57/BL6 male mice (aged 7-8 weeks and with the weight of about 20 g) to prepare a Parkinson disease model, and the MPTP molding method comprises the steps of injecting MPTP 20mg/kg/d into the abdominal cavity, continuously injecting the MPTP for 14 days and intermittently injecting the MPTP for 3 days to ensure that the dopamine neurons are subjected to sexual damage.
Taking successful SPF-grade C57/BL6 male mice for modeling as 10 groups, 20 mice in each group, respectively setting 9 experimental groups and 1 model control group corresponding to the above examples 1-6 and comparative examples 1-3, and taking 20 normal SPF-grade C57/BL6 male mice as a normal group; the 9 experimental groups respectively take the traditional Chinese medicine extract products prepared in corresponding examples 1-6 and comparative examples 1-3 for intragastric administration (the administration dose is 25mg/kg), and the normal group and the model control group are respectively intragastric with distilled water with the same volume; the method comprises the steps of twice a day, continuously administering for 14 days, testing the pole climbing capacity of a mouse after 14 days, recording pole climbing time, counting the times of autonomous activities of the mouse in a dark environment by adopting a program-controlled autonomous activity box, and counting for 3 minutes to obtain the specific results of the times of the autonomous activities of the mouse, wherein the specific results are shown in table 1.
TABLE 1
| Group of | Average rod climbing time (min) of mouse | Autonomic activity counting |
| Normal group | 3.1 | 100.5 |
| Model control group | 13.4 | 70.3 |
| Example 1 | 4.6 | 101.8 |
| Example 2 | 5.2 | 98.4 |
| Example 3 | 6.1 | 92.7 |
| Example 4 | 7.4 | 90.5 |
| Example 5 | 6.9 | 93.3 |
| Example 6 | 8.3 | 88.6 |
| Comparative example 1 | 10.5 | 83.4 |
| Comparative example 2 | 9.8 | 85.7 |
| Comparative example 3 | 9.3 | 86.3 |
Test example 2
The brain striatum of each group of mice in test example 1 was collected after the end of administration, and the content of Dopamine (DA) and its metabolites in the mouse striatum was measured by HPLC, and the results are shown in table 2.
TABLE 2
Typical case data:
case one: guo certain, female, 65 years old, tremor of the lower jaw and lips for 3 years, binocular absence, dark stagnation of complexion, pain or numbness of limbs, slow movement, muscle stiffness, difficulty in walking, salivation, belching, dark red tongue with cracks, little coating and thready and rapid pulse; after the traditional Chinese medicine extract product prepared in the embodiment 1 of the invention is taken, 3mL of the product is taken each time, 3 times a day, and three months are taken as a treatment course, after two treatment courses, the tremor symptom is relieved, after four treatment courses, the tremor and the salivation are improved obviously, after five treatment courses, the tremor and the numbness are relieved obviously, and the person can walk slowly and in small steps.
Case two: somebody in summer, male, age 76, stiff lower limbs, difficulty walking for 6 years. Poor coordination, inflexible activity, difficult walking, walking stick leaning, shaking of both upper limbs, shaking of head, anorexia, nausea, short breath, dry stool, and frequent cold and heat coming, sweating and palpitation; through examination, clear spirit, increased muscle tension of both lower limbs and upper limbs, resting tremor, crimson tongue, peeling off fur, wiry and thready pulse, short pulse on the right, and deep ulna; after the traditional Chinese medicine extract product prepared in the embodiment 2 of the invention is taken, 2mL of the product is taken each time, 3 times a day, and three months are taken as a treatment course, after the treatment course is taken, the walking difficulty of a patient is better than that of the patient in lifting the legs, the shortness of breath is reduced, and the patient can walk slowly under the protection of people after four treatment courses.
The preferred embodiments of the present invention have been described above in detail, but the present invention is not limited thereto. Within the scope of the technical idea of the invention, many simple modifications can be made to the technical solution of the invention, including combinations of various technical features in any other suitable way, and these simple modifications and combinations should also be regarded as the disclosure of the invention, and all fall within the scope of the invention.
Claims (10)
1. A traditional Chinese medicine composition for treating Parkinson's disease is characterized by comprising the following components: bombyx Batryticatus, radix Paeoniae alba, radix Polygoni Multiflori Preparata, radix scrophulariae, Corni fructus, radix rehmanniae Preparata, semen astragali Complanati, Poria, cortex moutan, Alismatis rhizoma, rhizoma Gastrodiae, ramulus Uncariae cum uncis, cortex Eucommiae, rhizoma anemarrhenae, Ecliptae herba, Haematitum, Concha Ostreae preparata, Saviae Miltiorrhizae radix, rhizoma Acori Graminei, Lumbricus, and Achyranthis radix.
2. The Chinese medicinal composition according to claim 1, wherein the composition comprises, relative to 10 parts by weight of the stiff silkworm, 2-25 parts by weight of white peony root, 5-30 parts by weight of prepared fleece flower root, 5-30 parts by weight of figwort root, 5-30 parts by weight of dogwood fruit wine, 5-30 parts by weight of prepared rehmannia root, 5-30 parts by weight of flastem milkvetch seed, 5-30 parts by weight of poria cocos, 2-20 parts by weight of moutan bark, 2-20 parts by weight of alisma orientale, 2-20 parts by weight of gastrodia elata, 5-30 parts by weight of uncaria, 2-20 parts by weight of salted eucommia ulmoides, 2-20 parts by weight of anemarrhena rhizome, 5-30 parts by weight of eclipta, 5-30 parts by weight of white peony root, 5-30 parts by weight of radix rehmanniae preparata, 5-30 parts by weight of semen astragali Complana, 2-30 parts by weight of poria cocos, 2-20 parts by weight of rhizoma anemarrhenae, 2-20 parts by weight of eclipta alba, and the like, 10-50 parts of ruddle, 10-50 parts of calcined oyster, 5-30 parts of salvia miltiorrhiza, 5-30 parts of rhizoma acori graminei, 2-20 parts of earthworm and 2-20 parts of achyranthes bidentata.
3. The traditional Chinese medicine composition according to claim 2, wherein the content of white peony root is 5-20 parts by weight, the content of prepared fleece-flower root is 10-20 parts by weight, the content of figwort is 10-20 parts by weight, the content of dogwood fruit processed with wine is 10-20 parts by weight, the content of prepared rehmannia root is 10-20 parts by weight, the content of flastem milkvetch seed is 10-20 parts by weight, the content of poria cocos is 10-20 parts by weight, the content of moutan bark is 5-15 parts by weight, the content of alisma orientale is 5-15 parts by weight, the content of gastrodia elata is 5-15 parts by weight, the content of uncaria is 10-20 parts by weight, the content of salted eucommia ulmoides is 5-15 parts by weight, the content of anemarrhena asphodeloides bunge, the content of eclipta alba is 10-20 parts by weight, the content of white peony root is 10-20 parts by weight, the content of prepared fleece-flower root and the medicinal composition is prepared by mixing, and the mixture of, 25-35 parts of ruddle, 25-35 parts of calcined oyster, 10-20 parts of salvia miltiorrhiza, 10-20 parts of rhizoma acori graminei, 5-15 parts of earthworm and 5-15 parts of achyranthes bidentata.
4. A preparation method of a traditional Chinese medicine preparation for treating Parkinson's disease is characterized by comprising the following steps:
(1) pulverizing Saviae Miltiorrhizae radix, semen astragali Complanati, rhizoma Gastrodiae, radix Paeoniae alba, radix scrophulariae, and Poria, and sieving to obtain mixed fine powder and mixed coarse residue;
(2) mixing Bombyx Batryticatus, radix Polygoni Multiflori Preparata, Corni fructus (processed with wine), radix rehmanniae Preparata, cortex moutan, Alismatis rhizoma, ramulus Uncariae cum uncis, cortex Eucommiae (processed with salt), rhizoma anemarrhenae, Ecliptae herba, Haematitum, Concha Ostreae preparata, rhizoma Acori Graminei, Lumbricus, Achyranthis radix, and the mixed coarse residue obtained in step (1) with water, decocting, filtering to obtain water extract, and concentrating under reduced pressure to obtain extract;
(3) and (3) mixing the mixed fine powder obtained in the step (1) with the extract obtained in the step (2), adding pharmaceutically acceptable auxiliary materials and/or drying to obtain the traditional Chinese medicine preparation for treating the Parkinson's disease.
5. The preparation method of claim 4, wherein the white peony root is used in an amount of 2-25 parts by weight, the prepared fleece-flower root is used in an amount of 5-30 parts by weight, the radix scrophulariae is used in an amount of 5-30 parts by weight, the dogwood fruit is used in an amount of 5-30 parts by weight, the prepared rehmannia root is used in an amount of 5-30 parts by weight, the flastem milkvetch seed is used in an amount of 5-30 parts by weight, the poria cocos is used in an amount of 5-30 parts by weight, the moutan bark is used in an amount of 2-20 parts by weight, the rhizoma alismatis is used in an amount of 2-20 parts by weight, the rhizoma gastrodiae is used in an amount of 2-20 parts by weight, the uncaria rhynchophylla is used in an amount of 2-30 parts by weight, the salted eucommia ulmoides is used in an amount of 2-20 parts by weight, the rhizoma anemarrhenae is used in an amount of 5-30 parts by weight, the eclipta is used in an amount, and the ruddle is used in an amount of 10-50 parts by weight, relative to 10 parts by weight of the stiff silkworm, The usage amount of calcined oyster shell is 10-50 weight portions, the usage amount of salvia miltiorrhiza is 5-30 weight portions, the usage amount of grassleaf sweelflag rhizome is 5-30 weight portions, the usage amount of earthworm is 2-20 weight portions, and the usage amount of achyranthes bidentata is 2-20 weight portions;
preferably, the weight of the white peony root is 5-20 parts, the weight of the prepared fleece-flower root is 10-20 parts, the weight of the figwort is 10-20 parts, the weight of the cornus officinalis processed with wine is 10-20 parts, the weight of the prepared rehmannia root is 10-20 parts, the weight of the flastem milkvetch seed is 10-20 parts, the weight of the poria cocos is 10-20 parts, the weight of the moutan bark is 5-15 parts, the weight of the alisma orientale is 5-15 parts, the weight of the gastrodia elata is 5-15 parts, the weight of the uncaria rhynchophylla is 10-20 parts, the weight of the salted eucommia ulmoides is 5-15 parts, the weight of the anemarrhena rhizome is 5-15 parts, the weight of the eclipta alba is 10-20 parts, the weight of the ruddle is 25-35 parts, the weight of the calcined oyster shell is 25-35 parts, the weight of the white peony root is 10-20 parts, the radix scrophulariae, the cornus officinalis is 10-20 parts, the astragalus mongholicus and the white peony root are 10-20 parts, The dosage of the salvia miltiorrhiza is 10 to 20 weight portions, the dosage of the grassleaf sweelflag rhizome is 10 to 20 weight portions, the dosage of the earthworm is 5 to 15 weight portions, and the dosage of the twotooth achyranthes root is 5 to 15 weight portions.
6. The method according to claim 4 or 5, wherein the sieved screen in step (1) is a 150-200 mesh screen, and the filtered screen in step (2) is a 100-200 mesh screen.
7. The process according to claim 4 or 5, wherein the number of times of said decocting in step (2) is 2 to 4, and the filtrates obtained by filtration after each decocting are combined to obtain said aqueous extract;
in each decocting process, the weight ratio of the total weight of the traditional Chinese medicine raw materials to water is 1: 3-8, wherein the decocting at least meets the following conditions: the decocting temperature is 100-.
8. The method according to claim 4 or 5, wherein the density of the extract in step (2) at 50 ℃ is 1.15-1.25 g/mL.
9. The preparation method according to any one of claims 4 to 8.
10. A traditional Chinese medicine product for treating Parkinson's disease, which is characterized by comprising the traditional Chinese medicine composition of any one of claims 1 to 3 or the traditional Chinese medicine preparation prepared by the preparation method of any one of claims 4 to 8.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2411028A1 (en) * | 2009-03-27 | 2012-02-01 | Moleac Pte Ltd. | Therapy for promoting cell growth |
| CN103127399A (en) * | 2013-02-03 | 2013-06-05 | 李振光 | Chinese medicine decoction for treating Parkinson disease |
| CN104800606A (en) * | 2015-04-29 | 2015-07-29 | 赵汝君 | Traditional Chinese medicine composition for treating Parkinson's syndrome |
| CN108743822A (en) * | 2018-09-04 | 2018-11-06 | 刘露 | A kind of Chinese medicine oil for treating Parkinson's disease |
-
2021
- 2021-07-15 CN CN202110802164.6A patent/CN113476558B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2411028A1 (en) * | 2009-03-27 | 2012-02-01 | Moleac Pte Ltd. | Therapy for promoting cell growth |
| CN103127399A (en) * | 2013-02-03 | 2013-06-05 | 李振光 | Chinese medicine decoction for treating Parkinson disease |
| CN104800606A (en) * | 2015-04-29 | 2015-07-29 | 赵汝君 | Traditional Chinese medicine composition for treating Parkinson's syndrome |
| CN108743822A (en) * | 2018-09-04 | 2018-11-06 | 刘露 | A kind of Chinese medicine oil for treating Parkinson's disease |
Non-Patent Citations (1)
| Title |
|---|
| 黄少东: "中药复方辩证治疗帕金森病的临床和实验研究", 《中华中医药学刊》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116726138A (en) * | 2023-08-11 | 2023-09-12 | 中国人民解放军总医院第六医学中心 | Traditional Chinese medicine composition for treating senile parkinsonism and complications, and preparation method and application thereof |
| CN116726138B (en) * | 2023-08-11 | 2023-11-24 | 中国人民解放军总医院第六医学中心 | Traditional Chinese medicine composition for treating senile parkinsonism and complications, and preparation method and application thereof |
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