CN113476506A - Astragalus root body resistance strengthening tea with function of regulating immunity and preparation method thereof - Google Patents
Astragalus root body resistance strengthening tea with function of regulating immunity and preparation method thereof Download PDFInfo
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- CN113476506A CN113476506A CN202110790103.2A CN202110790103A CN113476506A CN 113476506 A CN113476506 A CN 113476506A CN 202110790103 A CN202110790103 A CN 202110790103A CN 113476506 A CN113476506 A CN 113476506A
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Abstract
The invention relates to astragalus strengthening tea with an immune regulating function and a preparation method thereof, belonging to a medical preparation derived from plants. The astragalus root healthy energy strengthening tea comprises the following active ingredient raw materials: 5-6 g of astragalus; 3-5 g of codonopsis pilosula; is selected from one or more of 3g of Chinese date, 5-9 g of medlar and 3-5 g of dried orange peel.
Description
Technical Field
The invention relates to astragalus strengthening tea with an immune regulating function and a preparation method thereof, belonging to a medical preparation derived from plants.
Background
In the history of Chinese medicine development, the medicinal tea is a special Chinese herbal medicine preparation for preventing and curing diseases, building up body and prolonging life in clinic. The medicinal tea integrates edible and medicinal functions, is a beverage and a medicine, and is an organic combination of body building, health preserving and heart repairing. Edible and medicinal, both of which have been developed with changes in drinking tea.
At present, the medicinal tea sold in the market of China comprises more than ten varieties of ginkgo tea, ganoderma lucidum tea, pine tea, eucommia tea and the like. Moreover, a lot of medicinal tea has been introduced into the international market, and especially a lot of health-care medicinal tea, such as Jiangxining red series products, Hunan Bailong brand eucommia tea and the like, prevail in Japan, southeast Asia, Europe and America and other countries, makes contributions to the health care industry of the world people, and also greatly promotes the development of regional economy and the flourishing broadcast of regional brands. However, due to insufficient processing capacity and insufficient technological transformation, the traditional Chinese medicine industry in Shanxi is still at a low-end level in the field of processing and value-added of medicinal tea, the product chain and the economic chain are short, and the resource advantage cannot be transformed into the economic advantage.
Astragalus membranaceus, which is a representative medicinal material in Shanxi province, is listed as the top grade in Shennong's herbal Jing, and 2015 edition of Chinese pharmacopoeia specifies that Astragalus membranaceus astragaluus (Fisch.) bge. or Astragalus membranaceus Mongolia A. membranaceus (Fisch.) bge. var. mongholicus bge. Hsiao. Astragalus root is a well-known common traditional Chinese medicine, and is the first of the tonic medicines. Has effects in invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, promoting fluid production, nourishing blood, activating stagnancy, relieving arthralgia, expelling pus, healing sore, and promoting granulation. The traditional Chinese medicine composition is used for treating qi deficiency and hypodynamia, anorexia and loose stool, collapse of middle-jiao energy, chronic diarrhea and rectocele, hematochezia and metrorrhagia, exterior deficiency and spontaneous perspiration, qi deficiency and edema, internal heat and thirst, blood deficiency and chlorosis, hemiplegia, numbness and numbness of pain, carbuncle and cellulitis difficult to ulcerate, chronic ulceration and no convergence and the like, has obvious curative effect and wide application prospect, and enjoys high reputation at home and abroad.
The radix astragali mainly contains triterpenoid saponin, flavonoid compound and polysaccharide, wherein the saponin components comprise astragalosides I, II, III, IV, V, VI, VII, VIII, acetyl astragaloside I, isoastragalosides I and II, soyasaponin I and astragalosides I and II. The flavonoid component comprises kaempferol, quercetin, isorhamnetin, rhamnitrin, and Bambusoidin and its glycosides. The astragalus polysaccharides include AG-1, AG-2, AH-1, AH-2 and astragalus polysaccharides I, II, III. Modern pharmacological research shows that astragalus has positive effects on cardiovascular system, blood and hematopoietic system, liver and kidney organs, can enhance immunity, and has anticancer, antiviral and antiaging effects.
The astragalus root related medicinal tea researched and developed at present in China comprises gynostemma pentaphylla and astragalus root health-care tea, astragalus root six-health-care tea and the like. How to set up the advantages of the radix astragali traditional Chinese medicinal material resources in Shanxi to research and develop the specific radix astragali medicinal tea in the area so as to help the Shanxi economic development, raise the famous sound of the province and make due contribution to the national health medical industry becomes an important problem facing the development of the radix astragali traditional Chinese medicinal material industry in the whole province.
The medicinal tea is divided into two types, namely health-care medicinal tea and treatment medicinal tea, the health-care medicinal tea is mainly used in the market, and the research and development of medicinal tea with health-care and treatment functions is a new trend for the development of the medicinal tea market in the future. The method is also a guiding idea for developing astragalus membranaceus medicinal tea products. The low immunity is a common clinical disease and a frequently encountered disease, can cause a plurality of diseases, and is particularly easy to cause for middle-aged and elderly people and infants. The search for safe and efficient traditional Chinese medicinal materials which are compatible with astragalus and used as both medicine and food and have the effect of regulating immunity is particularly important.
Based on the research, the inventor aims to carry out the industrialized development and research of medicinal tea on the traditional Chinese medicinal material resources of the Shanxi dominant astragalus, and carries out the systematic research on the tea making process, the pilot production, the quality control, the stability, the functionality and the safety of the astragalus and codonopsis pilosula medicinal material, so that the astragalus and codonopsis pilosula medicinal material is developed into the medicinal tea which meets the requirements of people with low immunity and integrates the health care and the treatment. Further more effectively develop and utilize the astragalus resource of Shanxi province, promote the quality improvement and upgrade of the Shanxi herb tea industry, strive to create the seventh tea line of China, promote the regional economic development and the income improvement of people, and make due contribution to the health medicine and the Chinese medicine internationalization.
CN102166227 discloses a pharmaceutical composition with immunity enhancing effect, which comprises colla Corii Asini, vitamins and minerals, and also comprises one or more of rehmanniae radix, radix Codonopsis, radix astragali, fructus Jujubae, rhizoma Ligustici Chuanxiong, fructus Lycii, Atractylodis rhizoma and radix Angelicae sinensis, soybean isoflavone and fructo-oligosaccharide. The composition can be made into pharmaceutical preparation such as tablet, granule, pill, oral liquid, capsule, etc., food, beverage, and optionally milk powder or milk powder.
CN104095993 discloses a ganoderma lucidum granule for enhancing immunity, which is prepared by taking radix codonopsis pilosulae, radix astragali, ganoderma lucidum, medlar and Chinese date as main active ingredients and dextrin as an auxiliary material. The Chinese medicinal composition has effect in enhancing immunity, and can be used for preparing health promotion medicine for enhancing immunity.
CN104055935 discloses a Chinese medicinal composition for synergistically improving immunity, which takes codonopsis pilosula, astragalus root, ganoderma lucidum, medlar and Chinese date as main active ingredients.
CN101912455 discloses a Chinese medicinal composition for treating blood deficiency and qi weakness. The medicine is prepared from radix astragali, radix Angelicae sinensis, radix Codonopsis, and fructus Jujubae. Extracting the above materials with water, concentrating the water extractive solution to obtain extract, drying, and making into powder. The medicine has effects of benefiting qi for promoting production of blood, is suitable for treating blood deficiency and qi weakness, and has effects of stopping bleeding, relieving pain, enhancing immunity, recovering spleen and liver atrophy, improving weight reduction, recovering and enhancing physical strength, and reducing uterus smooth muscle contraction.
CN103584092 discloses a health care composition for enhancing immunity and resisting fatigue and a preparation thereof, which mainly comprises: astragalus root, pilose asiabell root, wolfberry fruit and malt.
The prior art does not disclose the astragalus root strengthening tea which is completely the same as the astragalus root strengthening tea of the invention.
Disclosure of Invention
The invention relates to astragalus strengthening tea with an immune regulating function and a preparation method thereof, and particularly relates to astragalus strengthening tea with an immune regulating function and a preparation method thereof, wherein the astragalus strengthening tea comprises the following components in parts by weight:
1. an astragalus root healthy tea with the function of regulating immunity is characterized in that: the effective component raw materials of the astragalus root healthy energy strengthening tea comprise (or consist of the following components): 5-6 g of astragalus; 3-5 g of codonopsis pilosula; is selected from one or more of 3g of Chinese date, 5-9 g of medlar and 3-5 g of dried orange peel.
2. The Astragalus membranaceus healthy tea with an immune-modulating function according to item 1 above, which is characterized in that: the effective component raw materials of the astragalus root healthy energy strengthening tea comprise (or consist of the following components): 6g of astragalus, 3g of codonopsis pilosula and 3g of Chinese date.
3. The Astragalus membranaceus healthy tea with an immune-modulating function according to item 2 above, which is characterized in that: the active ingredient raw materials of the astragalus root healthy energy strengthening tea also comprise 1g of roselle and 2 stevia rebaudiana slices; or consist of them.
4. The astragalus membranaceus body resistance strengthening tea with an immune regulating function according to item 1 or 2, which is characterized in that: the active ingredient raw materials of the astragalus strengthening tea comprise 6g of astragalus, 3g of codonopsis pilosula, 3g of Chinese date, 9g of Chinese wolfberry and 3g of dried orange peel.
5. The Astragalus membranaceus healthy tea with an immune-modulating function according to item 1 above, which is characterized in that: the effective component raw materials of the astragalus root healthy energy strengthening tea comprise 5g of astragalus root, 5g of codonopsis pilosula and 5g of medlar.
6. The Astragalus membranaceus healthy tea with an immune-modulating function according to item 1 above, which is characterized in that: the effective component raw materials of the astragalus root healthy energy strengthening tea comprise 5g of astragalus root, 5g of codonopsis pilosula and 5g of dried orange peel.
7. The preparation method of the astragalus membranaceus healthy tea with the function of regulating immunity according to any one of items 1 to 6 comprises the step of combining the active ingredient raw materials of the astragalus membranaceus healthy tea according to the mass ratio.
The combination comprises the physical mixing and non-mixing of the medicines.
8. The preparation method of the astragalus membranaceus healthy tea according to the 7, further comprising the steps of separately soaking the active ingredient raw materials of the astragalus membranaceus healthy tea in water, decocting for a period of time, and then mixing; or the active ingredient mixture of the astragalus root body resistance strengthening tea is soaked in water and decocted for a period of time.
9. The preparation method of the astragalus membranaceus body resistance strengthening tea according to the 7 th or 8, further comprising packaging the medicines obtained by combining or mixing according to unit units.
Description of the drawings:
FIG. 1 is a flow chart of the preparation process of the Astragalus root strengthening tea formula I, wherein the dotted line is a quality and sanitation strict control area.
FIG. 2 is a flow chart of the preparation process of the Astragalus root healthy tea formula II, wherein the dotted line is a quality and hygiene strict control area.
FIG. 3 is a flow chart of the preparation process of the Astragalus root healthy tea No. III, wherein the dotted line is a quality and hygiene strict control area.
FIG. 4 is a flow chart of the preparation process of the formula IV of the Astragalus root healthy tea, wherein a quality and sanitation strict control area is arranged in a dotted line.
FIG. 5 is a flow chart of the preparation process of the Astragalus root healthy tea V, wherein the dotted line is a quality and hygiene strict control area.
Detailed Description
The invention is further illustrated by the following description of specific embodiments, which are not intended to be limiting of the invention. It will be apparent to those skilled in the art that various modifications and improvements can be made to the basic concept of the invention without departing from the scope of the invention.
Animal testing
1 Material
1.1 Experimental animals
SPF-level Kunming mice 70 male, with a body mass of 20-23g, were purchased from Peking Wittisley laboratory animal science and technology, Inc. All animal feeding and experimental processes were scientifically tested according to the guidelines of the ethical committee on laboratory animals of Shanxi university of traditional Chinese medicine. Before the experiment, the animals are adaptively raised in an animal room without pathogenic bacteria for 1 week, the animals freely eat drinking water, the temperature is controlled to be (22 +/-2) DEG C, the relative humidity is 40-60 percent, the ventilation is good, and the illumination is alternated for 12 hours day and night.
1.2 Experimental drugs
The preparation process is shown in 2.2 for the preparation of the astragalus strengthening tea.
1.3 laboratory instruments and reagents
A blood cell analyzer (Shenzhen Merrill biomedical electronics GmbH, model number: BC-2800 Vet); high-speed refrigerated centrifuges (Eppendorf, Germany, type: 5840); electronic balances (Sartorius, Germany, model: CPA); a vertical high-pressure steam sterilization pot (Shanghai Boxun medical biological instruments GmbH, model: YXQ-LS-50S II); a digital display constant temperature magnetic stirrer (Jiangsu middle and large instrument science and technology limited, model: T8-1); dry heat sterilization cases (Shanghai Boxun medical BioMeter, Inc., model: GRX-12A).
Cyclophosphamide (CTX, lot: 2011027) was purchased from Shanghai Hualian pharmaceutical Co., Ltd; conventional reagents such as physiological saline are commercially available from Beijing Solaibao science and technology Co.
2 method
2.1 preparation of herb tea
2.1.1 Astragalus root strengthening tea No. I prescription
2.1.1.1 prescription and prescription basis
Prescription: 6g of astragalus root, 3g of codonopsis pilosula, 3g of Chinese date, 9g of Chinese wolfberry and 3g of dried orange peel
According to the following: food safety law of the people's republic of China (guardian institute of health & Law [2018 ]); raw material enterprise standards and national relevant standards and regulations.
2.1.1.2 method for improving health and protecting health
The main functions are as follows: tonify qi to invigorate the spleen, replenish qi to calm the nerves.
The method is suitable for people: has the effects of relieving fatigue, reducing qi, disinclining to talk, and relieving sallow complexion.
Character odor: the product is brown yellow fine granule, and the soup color is light yellow; slightly sweet taste and slight astragalus smell.
The usage and dosage are as follows: 5g per bag, orally taken, 1 bag per time, and brewed with warm boiled water.
Storage conditions: and (5) storing in a sealed and light-proof manner at normal temperature. Shelf life: and (4) 18 months.
2.1.1.3 operating Processes and Process conditions
Cleaning raw materials: the raw materials are picked, impurities, fragments and the like in the raw materials are removed, and the raw materials are cleaned/aired by drinking water for later use.
And (3) immersion treatment: soaking radix astragali (bag), radix Codonopsis, fructus Jujubae, fructus Lycii and pericarpium Citri Tangerinae in water for 60min, decocting for 60min, removing residues to obtain medicinal liquid, concentrating to 40mL, oven drying radix astragali for 2h, pulverizing dried radix astragali, mixing with the concentrated medicinal liquid, and drying for 2 h.
2.1.2 Astragalus root body resistance strengthening tea II prescription
2.1.2.1 prescription and prescription basis
Prescription: astragalus root 6g, pilose asiabell root 3g, Chinese date 3g
The prescription is as follows: the food safety law of the people's republic of China (guardian initiative 2018); raw material enterprise standards and national relevant standards and regulations.
2.1.2.2 method for improving health and protecting health
The main functions are as follows: to replenish qi, invigorate the spleen, nourish blood and soothe the nerves.
The method is suitable for people: has the symptoms of weakness of the spleen and the stomach and deficiency of qi and blood, such as mental fatigue, qi deficiency, disinclination to talk, sallow complexion and the like.
Character odor: the product is yellow brown fine granule, and the soup color is light yellow. Slightly sweet taste and slight astragalus smell.
The usage and dosage are as follows: 5g per bag, orally taken, 1 bag per time, and brewed with warm boiled water.
Storage conditions: and (5) storing in a sealed and light-proof manner at normal temperature. Shelf life: and (4) 18 months.
2.1.2.3 operating process and process conditions
Cleaning raw materials: the raw materials are picked, impurities, fragments and the like in the raw materials are removed, and the raw materials are cleaned/aired by drinking water for later use.
And (3) immersion treatment: soaking radix astragali (bag), radix Codonopsis, and fructus Jujubae in water for 60min, decocting for 60min, removing residues to obtain medicinal liquid, concentrating to 40mL, oven drying radix astragali for 2 hr, pulverizing dried radix astragali, mixing with the concentrated medicinal liquid, and drying for 2 hr.
2.1.3 Astragalus root strengthening tea III prescription
2.1.3.1 prescription and prescription basis
Prescription: 6g of astragalus, 3g of codonopsis pilosula, 3g of Chinese date, 1g of roselle and 2 stevia rebaudiana tablets
The prescription is as follows: food safety law of the people's republic of China (guardian institute of health & Law [2018 ]); raw material enterprise standards and national relevant standards and regulations.
2.1.3.2 functional, applicable, Properties, dosage and storage methods
The main functions are as follows: tonify middle-jiao and qi, invigorate spleen and harmonize stomach.
The method is suitable for people: has the symptoms of mental fatigue, qi deficiency, no speaking desire, cough, inappetence and the like.
Character odor: mixing the dried radix astragali granule decocted in brown or yellow brown block with pulverized calyx Hibisci Sabdariffae and pulverized green stevia rebaudiana Bertoni. The taste is slightly sour and sweet, the taste is slightly astragalus, the smell is fragrant and fragrant, and the typical red date fragrance is realized;
the usage and dosage are as follows: 5g per bag, orally taken, 1 bag per time, and brewed with warm boiled water.
Storage conditions: and (5) storing in a sealed and light-proof manner at normal temperature. Shelf life: and (4) 18 months.
2.1.3.3 operating process and process conditions
Cleaning raw materials: the raw materials are picked, impurities, fragments and the like in the raw materials are removed, and the raw materials are cleaned/aired by drinking water for later use.
Processing astragalus, codonopsis pilosula, red dates, roselle and stevia rebaudiana, wherein the processing steps comprise: the selected medicinal materials are added with 1000mL of drinking water according to 6g of astragalus decoction pieces, 3g of codonopsis pilosula and 3g of Chinese date for soaking at room temperature for 3-4h, the astragalus decoction pieces are cut into astragalus fragments after water control, and the astragalus fragments are packaged and dried. Mashing 1 roselle, and cutting 2 pieces of stevia rebaudiana.
Liquid immersion and stir-frying treatment: decocting radix Codonopsis, fructus Jujubae and the soaked water for 1.5h, removing residues to obtain medicinal liquid, and concentrating to 20 mL; mixing the dried radix astragali and the concentrated medicinal liquid, and soaking for 1 hr until the radix astragali pieces are full of medicinal liquid; and finally, stir-frying the residual medicine juice and the astragalus root fragments with small fire until the medicine juice and the astragalus root fragments are completely absorbed and wrapped, and continuously drying.
2.1.4 Astragalus root body resistance strengthening tea IV prescription
2.1.4.1 prescription and prescription basis
Prescription: 5g of astragalus root, 5g of pilose asiabell root and 5g of Chinese wolfberry fruit
The prescription is as follows: food safety law of the people's republic of China (guardian institute of health & Law [2018 ]); raw material enterprise standards and national relevant standards and regulations.
2.1.4.2 method for improving health and protecting health
The main functions are as follows: tonify middle-jiao and Qi, nourish kidney and moisten lung.
The method is suitable for people: has the symptoms of qi deficiency and hypodynamia, no desire to speak, shortness of breath, weakness of limbs, soreness and weakness of waist and knees, blurred vision and lacrimation.
Character odor: decocting ash brown or reddish brown sheet, and mixing with the mixture of fructus Lycii. Fragrant and sweet taste, slight astragalus smell and slightly fragrant smell.
The usage and dosage are as follows: 10g per bag, orally taken, 1 bag per time, and brewed with warm boiled water.
Storage conditions: and (5) storing in a sealed and light-proof manner at normal temperature. Shelf life: and (4) 18 months.
2.1.4.3 operating process and process conditions
Cleaning raw materials: the raw materials are picked, and impurities and fragments in the raw materials are removed for later use.
Treating astragalus, codonopsis pilosula and medlar: wrapping the selected radix Codonopsis decoction pieces with clean gauze, soaking with radix astragali decoction pieces in 100g of 2000mL drinking water at room temperature for 1h, decocting for 1h, removing residues, concentrating the decoction to 50mL, mixing with dried radix Codonopsis, steaming for 1h, taking out radix Codonopsis, and drying for use. Cleaning and airing the medlar for later use.
2.1.5 Astragalus root body resistance strengthening tea V prescription
2.1.5.1 prescription and prescription basis
Prescription: astragalus root 5g, pilose asiabell root 5g, dried orange peel 5g
The prescription is as follows: food safety law of the people's republic of China (guardian institute of health & Law [2018 ]); raw material enterprise standards and national relevant standards and regulations.
2.1.5.2 method for improving health and protecting health
The main functions are as follows: tonify qi, strengthen superficies, regulate qi and invigorate spleen.
The method is suitable for people: deficiency of qi, asthenia, laziness in speaking, weakness of limbs, soreness of the waist and knees, etc.
Character odor: and drying the orange peel in a brown yellow or orange strip shape. Fragrant and sweet taste, slight astragalus smell and slightly fragrant smell.
The usage and dosage are as follows: 10g per bag, orally taken, 1 bag per time, and brewed with warm boiled water.
Storage conditions: and (5) storing in a sealed and light-proof manner at normal temperature. Shelf life: and (4) 18 months.
2.1.5.3 operating process and process conditions
Cleaning raw materials: the raw materials are picked, and impurities and fragments in the raw materials are removed for later use.
Treating astragalus and codonopsis pilosula: wrapping the selected pericarpium Citri Tangerinae decoction pieces with clean gauze, soaking in 2000mL drinking water at room temperature for 1h, decocting for 1h, removing residues, concentrating to 50mL, mixing with dried pericarpium Citri Tangerinae, steaming for 1h, taking out pericarpium Citri Tangerinae, and oven drying.
2.2 animal grouping and handling
Kunming mouse 70 was divided into 7 groups by the random number table method, and each group consisted of 10 mice, namely normal group, model group, Huangqi Fuzheng tea No. I square group, Huangqi Fuzheng tea No. II square group, Huangqi Fuzheng tea No. III square group, Huangqi Fuzheng tea No. IV square group and Huangqi Fuzheng tea No. V square group. 1d to 3d, except normal group intraperitoneal injection of normal saline, other groups of mice are intraperitoneal injection of CTX (80mg/kg/d), and an immunosuppressive mouse model is established. From the 4 th day, the mice in the square groups of the astragalus root strengthening tea I, II, III, IV and V are respectively filled with corresponding herb tea at the ratio of 3.2g/kg/d and 0.2 mL/time for 28 days continuously, and the normal group and the model group are given with the same volume of normal saline. Sampling tests were performed 24h after the last administration.
2.3 detection index and method
2.3.1 routine blood determination
After 24h of the last administration, the mouse eyeballs were removed with sterilized ophthalmic forceps and whole blood was collected with an anticoagulation tube to prevent blood coagulation. Within 12h, a full-automatic blood cell analyzer is adopted to detect the white blood cell count (WBC), the red blood cell count (RBC) and the platelet count (PLT).
2.3.2 immune organ index determination
Weighing each group of mice, collecting blood, dislocating cervical vertebra to kill the mice, separating thymus and spleen, cleaning bloodstain, sucking water by using filter paper, accurately weighing and recording wet weight respectively, and calculating spleen index and thymus index of each experimental animal according to the following formulas according to the mass of the mice at the experimental end point:
spleen index spleen weight (mg)/mouse body weight (g)
Thymus index ═ weight of thymus (mg)/weight of mouse (g)
2.3.3 statistical methods
Data analysis was performed using GraphPad Prism 8.0 statistical software, and the mean. + -. standard deviation was used for data measurementRepresenting two-by-two comparison by t test and between-group comparison by one-way analysis of variance (ANOVA), P<0.05 the difference was considered statistically significant.
3 results
3.1 Effect on blood routine
Peripheral blood WBC, RBC and PLT were analyzed in 7 groups of mice, and the results are shown in table 1. Compared with the normal group, 3 indexes of WBC, RBC and PLT of the immunosuppressed mice in the model group are obviously reduced, and the difference is obvious (P <0.01), which indicates that the model building is successful. Compared with the model group, the WBC, RBC and PLT of the astragalus strengthening tea I and III are obviously increased (P is less than 0.01); the three indexes of the IV prescription of the astragalus strengthening tea are also obviously increased (P is less than 0.05); WBC of the radix astragali body resistance strengthening tea No. II square group is increased (P is less than 0.05), and RBC and PLT have ascending trend; the WBC and RBC of the astragalus strengthening tea V-type square mouse are increased obviously, and the PLT also tends to increase.
Note: in comparison with the normal group,**P<0.01; in comparison with the set of models,#P<0.05,##P<0.01。
3.2 Effect on immune organ index
The organ indexes of 7 groups of mice were measured and analyzed, and the results are shown in table 2. Compared with the normal group, the spleen index and the thymus index of the model group immunosuppression type mice are both obviously reduced (P <0.01), which indicates that the CTX can damage the mouse organs and obviously shrink the mouse organs. Compared with the model group, the visceral index of each group of mice with the astragalus root strengthening tea is increased to different degrees. Wherein, spleen index and thymus index of the astragalus strengthening tea I and III mice are obviously increased (P < 0.01); the organ indexes of the astragalus root strengthening tea II and V-type square group mice are also obviously up-regulated (P is less than 0.05); the spleen index difference (P <0.05) and the thymus index difference (P <0.01) of the mice in the IV-type formulation of the astragalus strengthening tea are obvious.
Note: in comparison with the normal group,**P<0.01; in comparison with the set of models,#P<0.05,##P<0.01。
discussion 4
The immunity refers to the function of the body immune system to recognize self and foreign matters and eliminate antigenic foreign matters through immune response so as to maintain the normal physiological balance of the body. The immunity is a self defense mechanism of a human body and is the capability of resisting external invasion and maintaining the stability of the internal environment of the body. It is widely believed that the health condition of the body is closely related to immune function, and when the immune function of the body is reduced or inhibited, the body resistance is reduced, the body constitution is deteriorated, foreign bacteria, viruses and other substances cannot be effectively recognized and eliminated, the incidence of diseases is increased, and the body often feels fatigue[1]. The immunity of the human body is improved, and the human body is protected from being damaged,the development of functional herbal tea with high safety and immune enhancement is one of the hot spots of current researchers.
The traditional Chinese medicine holds that healthy qi is a basic substance for resisting exogenous pathogenic factors and preventing and treating diseases, maintains normal life activities of human bodies, leads the life activities of the human bodies and the diseases to return due to the exuberant decline and decay of the healthy qi, and is functional activities, disease resistance and rehabilitation capability of the human bodies. Su Wen (plain questions) includes that the healthy qi exists in the interior and the pathogenic factors cannot be dried. In this respect, the healthy qi of traditional Chinese medicine is reflected in the immunity of human body in modern medicine[2]. The deficiency of healthy qi causes the pathogenic qi to enter the body, resulting in disorder of function and hypoimmunity. The traditional Chinese medicine has proved to have high safety and clinical effectiveness in long-term development, and the regulation and control effect on the immune system is continuously explored[3-4]。
The astragalus root is mild in nature and sweet in taste, is rich in various compounds such as polysaccharides, saponins, alkaloids and flavonoids, and has the effects of tonifying qi and invigorating yang, consolidating superficial resistance and arresting sweating, inducing diuresis and relieving swelling, and expelling toxin and pus. Modern pharmacological research shows that astragalus root and its extract have obvious immunological regulation, antitumor, antioxidant and other pharmacological activity[5-8]. Radix Codonopsis has effects of invigorating spleen and replenishing qi, invigorating spleen and benefiting lung, and can promote healthy qi and middle-warmer energy of human body. The research of codonopsis pilosula on the aspect of body immune regulation is extensive and deep. The Codonopsis pilosula polysaccharide has strong promotion effect on humoral immunity, can promote proliferation of mouse spleen B lymphocytes, improve phagocytic ability of mouse macrophages, and further adjust organism immunity function[9-10]. The astragalus and codonopsis pilosula are combined to tonify qi, nourish spleen and stomach, and have the effects of enhancing immunity, expanding blood vessels, reducing blood pressure, improving microcirculation, enhancing hematopoietic function and the like. Can be used for treating lassitude, soreness of waist and knees, dizziness, amnesia, blurred vision, hyperhidrosis, and diabetes. On the basis, the research observes the immunoregulation effect of the astragalus strengthening tea on immunosuppressive mice.
CTX is commonly used for constructing animal models with low immune function or suppressed immune function, can obviously reduce the body mass of animals and influence cell factors related to peripheral immune organs, lymph organs and organism immunity[11]. Peripheral lymph organ bagIncluding blood, lymphatic vessels and immunocompetent cells, the influence of the astragalus strengthening tea on the immune function of the body is observed by detecting the peripheral blood routine of a mouse in the research. Research results show that the astragalus root healthy-strengthening tea can effectively improve the blood WBC, RBC and PLT of immunosuppressed mice, relieve the inhibition effect of CTX on bone marrow, promote the recovery and progression of bone marrow hematopoietic function and improve the bone marrow hematopoietic function.
The immune organ is a basic place for exerting the immune function, the thymus and the spleen are important immune organs of the body, and the development conditions of the thymus and the spleen are closely related to the immune function of the body. Wherein, the spleen is an important peripheral immune organ in the body, has nonspecific and specific immune functions, and not only can be used as a place for the colonization of immune cells, but also can be used as a place for receiving antigen stimulation to generate immune response; the thymus, as a central immune organ, is the site where the body has an immune response after being stimulated by an antigen, and is the site where cells develop and mature. The increase of the weight of spleen and thymus organs represents the proliferation of lymphocytes in the organs, and the intensity of the immune response level of the organism is often reflected by the proliferation degree of the lymphocytes[12]. Therefore, the thymus index and the spleen index can better reflect the development degree of immune organs and the function of immune cells, thereby further reflecting the strength of the immune function of the body[13-14]. In the study, the influence of the astragalus strengthening tea on the organ index of a CTX-induced immunosuppressed mouse is detected. The results show that after the medicine treatment, the astragalus root healthy-strengthening tea has the most obvious effect of increasing the thymus index and the spleen index of a CTX immunosuppressive mouse model, and the improvement of the immune function of an organism is proved.
In summary, the research is based on an immunosuppressive mouse model, and the astragalus strengthening tea is found to have the functions of protecting and enhancing the immune function in vivo research. The astragalus root body resistance strengthening medicinal tea prepared by the process is safe and effective, has no toxic or side effect, can be taken for a long time, and is a promising medicinal tea capable of obviously improving the immune function.
Crowd observation
The basic research shows that the formula I of the astragalus strengthening tea has stronger protection and enhancement effects on the immune function of the immunosuppressive mouse body, and the effect is better than that of the astragalus strengthening tea with other formulas. Therefore, the effect of the astragalus root strengthening tea prescription I on people with low immunity is observed.
1. Situation of the tested population
132 middle aged and elderly people, 62 men and 70 women. The main symptoms comprise shortness of breath, disinclination to talk, spontaneous perspiration, night sweat, listlessness, inappetence and the like, and the effect is observed after the medicinal tea is taken.
2. Method of administration
5 g/bag, 1 bag/time, 2 times/d, soaking with warm boiled water for drinking, and insisting taking for a course of 90 days.
3. Criteria for determination
A. And (3) curing: the symptoms disappear completely
B. The method has the following advantages: the symptoms are obviously relieved
C. And (4) invalidation: no obvious improvement of symptoms
4. Therapeutic results
TABLE 3 Observation results of No. I population of Astragalus membranaceus healthy tea
As can be seen from the data in the table 3, the astragalus root healthy-strengthening tea prescription I has obvious effects on symptoms such as qi deficiency, laziness in speaking, listlessness, spontaneous perspiration, night sweat, inappetence and the like, can show obvious curative effects in one treatment course (in a short period), and is particularly beneficial to people with qi deficiency, laziness in speaking and listlessness.
5. Typical cases
Lai, male, age 62. In recent years, the mental state is not good, the body is usually lack of strength, the whole body sweats after slight exercise, the sleep quality is poor, the sleep is frogman 32429, and the sweat is easy to appear in the sleep and the memory is reduced. After the medicinal tea is taken for more than 90 days, the sleeping time at night is greatly prolonged, the sweating frequency is reduced, and the daytime spirit is obviously improved. After the medicine is continuously taken for 30 days, sweating symptoms disappear, the spirit is improved more and more, and some exercises can be properly performed.
Liu Jie, female, 56 years old. The body is fat, the body is weak, spontaneous perspiration and night sweat are obvious, fatigue and sleepiness are caused, the spirit is weak, and in recent years, the appetite is not good and the abdomen is full. After the medicinal tea is taken for 30 days, sweating is obviously reduced, and the appetite is obviously improved. After continuously taking the medicinal tea for 5 months, the sleeping time and times in the daytime are reduced, the activity is increased compared with the prior art, and the sweating amount after the activity is reduced. In the last month, the people have regular sleep, good spirit, free movement and relaxed body feeling.
In addition, in the observation and experiment of people, the astragalus root strengthening tea I, III, IV and V has better effects on symptoms such as qi deficiency, disinclination to talk, listlessness, spontaneous perspiration, night sweat, inappetence and the like.
Reference to the literature
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[7]Liu AJ,Yu J,Ji HY,et al.Extraction of a Novel Cold-Water-Soluble Polysaccharide from Astragalus membranaceus and Its Antitumor and Immunological Activities[J].Molecules,2017,23(01):62.
[8]LI W,SONG K,WANG S,et al.Anti-tumor potential ofastragalus polysaccharides on breast cancer cell line mediated by macrophage activation[J].Mater Sci Eng C MaterBiol Appl,2019,98(05):685-695.
[9] Hao-brilliant, neysuvian, what you expect, etc. the effect of different products of Codonopsis pilosula on immunosuppressed rats was explored based on-1 HNMR metabonomics technology [ J ] Chinese pharmacological report, 2019, 35 (09): 1266-1273.
[10] Contrast study of immunomodulatory effects of 4 kinds of traditional Chinese medicine polysaccharides such as hedysarum polybotrys on mice models with hypoimmunity caused by cyclophosphamide [ J ] journal of clinical pharmacology in china, 2017, 33 (21): 2175-2178+2186.
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Claims (9)
1. An astragalus root healthy tea with the function of regulating immunity is characterized in that: the effective component raw materials of the astragalus root healthy energy strengthening tea comprise (or consist of the following components): 5-6 g of astragalus; 3-5 g of codonopsis pilosula; is selected from one or more of 3g of Chinese date, 5-9 g of medlar and 3-5 g of dried orange peel.
2. The astragalus membranaceus body-strengthening tea having an immune function regulating function according to claim 1, which is characterized in that: the effective component raw materials of the astragalus root healthy energy strengthening tea comprise (or consist of the following components): 6g of astragalus, 3g of codonopsis pilosula and 3g of Chinese date.
3. The astragalus membranaceus body-strengthening tea with an immune function regulating function according to claim 2, which is characterized in that: the active ingredient raw materials of the astragalus root healthy energy strengthening tea also comprise 1g of roselle and 2 stevia rebaudiana slices; or consist of them.
4. The astragalus membranaceus body-strengthening tea having an immune function-regulating function according to claim 1 or 2, which is characterized in that: the active ingredient raw materials of the astragalus strengthening tea comprise 6g of astragalus, 3g of codonopsis pilosula, 3g of Chinese date, 9g of Chinese wolfberry and 3g of dried orange peel.
5. The astragalus membranaceus body-strengthening tea having an immune function regulating function according to claim 1, which is characterized in that: the effective component raw materials of the astragalus root healthy energy strengthening tea comprise 5g of astragalus root, 5g of codonopsis pilosula and 5g of medlar.
6. The astragalus membranaceus body-strengthening tea having an immune function regulating function according to claim 1, which is characterized in that: the effective component raw materials of the astragalus root healthy energy strengthening tea comprise 5g of astragalus root, 5g of codonopsis pilosula and 5g of dried orange peel.
7. The method for preparing astragalus membranaceus healthy tea with an immune function regulating function according to any one of claims 1 to 6, comprising combining the raw materials of the active ingredients of the astragalus membranaceus healthy tea according to the mass ratio of the raw materials.
8. The method for preparing astragalus membranaceus healthy tea according to claim 7, further comprising separately soaking the active ingredient raw materials of the astragalus membranaceus healthy tea in water, decocting for a period of time, and then mixing; or the active ingredient mixture of the astragalus root body resistance strengthening tea is soaked in water and decocted for a period of time.
9. The preparation method of the astragalus membranaceus body resistance strengthening tea as claimed in claim 7 or 8, further comprising packaging the combined or mixed medicines in unit units.
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CN114796357A (en) | 2022-07-29 |
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