CN113476161A - Flexible structure on surface of dental implant and construction method thereof - Google Patents
Flexible structure on surface of dental implant and construction method thereof Download PDFInfo
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- 239000004053 dental implant Substances 0.000 title claims abstract description 20
- 238000010276 construction Methods 0.000 title abstract description 16
- 239000007943 implant Substances 0.000 claims abstract description 92
- 239000010936 titanium Substances 0.000 claims abstract description 86
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims abstract description 80
- 229910052719 titanium Inorganic materials 0.000 claims abstract description 80
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 39
- 239000011148 porous material Substances 0.000 claims abstract description 22
- 238000011065 in-situ storage Methods 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 12
- 229910020293 Na2Ti3O7 Inorganic materials 0.000 claims abstract description 4
- 238000004140 cleaning Methods 0.000 claims description 16
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- 239000008367 deionised water Substances 0.000 claims description 10
- 229910021641 deionized water Inorganic materials 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000002071 nanotube Substances 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 4
- 238000004381 surface treatment Methods 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- 229910000883 Ti6Al4V Inorganic materials 0.000 claims description 3
- 210000000988 bone and bone Anatomy 0.000 abstract description 33
- 239000002131 composite material Substances 0.000 abstract description 10
- 230000009286 beneficial effect Effects 0.000 abstract description 7
- 210000001519 tissue Anatomy 0.000 abstract description 5
- 230000002708 enhancing effect Effects 0.000 abstract description 3
- 239000011734 sodium Substances 0.000 description 5
- 238000002441 X-ray diffraction Methods 0.000 description 4
- 230000003139 buffering effect Effects 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 2
- 210000002449 bone cell Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000000635 electron micrograph Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000001000 micrograph Methods 0.000 description 2
- 230000003239 periodontal effect Effects 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 238000010883 osseointegration Methods 0.000 description 1
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- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
- A61C8/0037—Details of the shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C22/00—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
- C23C22/05—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions
- C23C22/60—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using alkaline aqueous solutions with pH greater than 8
- C23C22/64—Treatment of refractory metals or alloys based thereon
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- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
- A61C8/0037—Details of the shape
- A61C2008/0046—Textured surface, e.g. roughness, microstructure
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- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
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Abstract
The invention discloses a flexible structure of a dental implant surface, which comprises a flexible porous channel structure layer constructed by a nano pipeline, wherein the nano pipeline grows on the surface of a titanium-based implant in situ, and the main component of the nano pipeline is Na2Ti2O5Or Na2Ti3O7. The pore canal in the flexible structure is beneficial to the bone tissue to grow into the flexible porous structure layer, and forms a biological composite structure with a nano pipeline-bone tissue three-dimensional staggered appearance with the nano pipeline, thereby being beneficial to enhancing the bone bonding strength of the implant and the alveolar bone interface. The flexible structure of the invention hasThe titanium-based implant has super-hydrophilic performance, certain elasticity and excellent tensile resistance, and after the flexible structure is added on the surface of the titanium-based implant, the tribological coefficient of the surface of the titanium-based implant cannot be increased, and the planting difficulty of a clinician in the using process cannot be increased. The construction method of the flexible structure uses simple NaOH solution treatment, namely, the nano pipeline is formed on the surface of the titanium-based implant by in-situ growth, and the operability is strong.
Description
Technical Field
The invention belongs to the field of oral implantation, and particularly relates to a flexible structure of a dental implant surface and a construction method thereof.
Background
The implant is one of the best methods for repairing the missing tooth at present, the commonly used implant is connected with the bone tissues of the peripheral alveolar bone in a screw-like mechanical locking mode, interface micromotion caused by the connection mode is one of important factors causing the implant to loose and lose efficacy, but an effective method for solving the bottleneck of the interface micromotion failure is not available at present.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a flexible structure on the surface of a dental implant and a construction method thereof, aiming at the defects of the prior art, the pore of a flexible porous structure layer constructed on the surface of a titanium-based implant is beneficial to bone tissues to grow into the flexible porous structure layer, and the flexible porous structure layer and the nano pipeline form a biological composite structure with a nano pipeline-bone tissue three-dimensional staggered appearance, and the biological composite structure is beneficial to enhancing the bone bonding strength of the interface of the implant and alveolar bone.
The technical scheme adopted by the invention for solving the technical problems is as follows: a flexible structure on the surface of dental implant is composed of a flexible porous structure layer made of nano-pipeline, which is in-situ grown on the surface of Ti-base implant and contains Na as main component2Ti2O5And/or Na2Ti3O7。
According to the invention, the flexible porous structure layer is constructed on the surface of the titanium-based implant, after the implant is implanted into the alveolar bone, the flexible porous structure layer can promote the combination of the implant and the alveolar bone, so that bone tissues grow into the flexible porous structure, and a biological composite structure with a nano pipeline-bone tissue three-dimensional staggered appearance, which is formed by compounding the flexible porous structure and the bone tissues, is formed between the implant and the alveolar bone interface, so that a flexible connection structure which is similar to a natural periodontal membrane and has friction buffering and protection performances is formed between the implant and the alveolar bone interface, the interface buffering is realized, the micro-motion failure problem on the surface of the implant is solved, the long-term stability and the service life of the titanium-based implant after being implanted into the alveolar bone are improved, and the service life of a tooth is prolonged.
Preferably, the outer diameter of the nano pipeline is 30-90 nm.
Preferably, the flexible porous structure layer has pores with a micrometer scale, and the pore diameter of the pores is 2-50 μm when viewed from the cross section of the flexible porous structure layer. The pore canal with the diameter of 2-50 mu m is beneficial to the bone tissue to grow into the flexible porous structure layer, and the flexible porous structure layer and the nano pipeline form a nano pipeline-bone tissue three-dimensional staggered biological composite structure.
Preferably, the titanium-based implant is made of pure titanium or titanium alloy.
Preferably, the pure titanium is medical titanium metal TA4, and the titanium alloy is Ti-6Al-4V titanium alloy, Ti-6Al-7Nb titanium alloy or Ti-3Zr-2Sn-3Mo-25Nb titanium alloy.
A construction method of the flexible structure on the surface of the dental implant comprises the steps of carrying out high-temperature treatment on the surface of a titanium-based implant in a closed container by using NaOH solution for at least 1 hour, growing a nano-pipeline on the surface of the titanium-based implant in situ, and constructing a flexible porous structure layer by using the grown nano-pipeline.
According to the construction method of the flexible structure on the surface of the dental implant, the surface of the titanium-based implant is subjected to high-temperature treatment by using NaOH solution, so that NaOH reacts with titanium on the surface of the titanium-based implant, and a nano pipeline grows on the surface of the titanium-based implant in situ. The chemical reaction formula is as follows:
the construction method of the flexible structure on the surface of the dental implant uses simple NaOH solution treatment, namely, the nano pipeline is formed on the surface of the titanium-based implant by in-situ growth, and the operability is strong.
Preferably, the method for constructing the flexible structure on the surface of the dental implant specifically comprises the following steps:
1) cleaning the titanium-based implant by sequentially adopting acetone, absolute ethyl alcohol and deionized water, and naturally drying;
2) soaking the titanium-based implant in a closed container filled with NaOH solution with the concentration of 0.5-2 mol/L, carrying out surface treatment on the titanium-based implant at 150-240 ℃, wherein the treatment time is 1-24 hours, so that a nano pipeline with the outer diameter of 30-90 nm grows on the surface of the titanium-based implant in situ, and then constructing a flexible porous structure layer with micron-scale pores with the pore diameter of 2-50 mu m by the nano pipeline formed by growth;
3) washing the titanium-based implant treated in the step 2) with deionized water, and naturally drying.
The construction method of the flexible structure on the surface of the dental implant comprises the following cleaning process in the step 1): firstly, ultrasonically cleaning a titanium-based implant by using acetone for at least 2 minutes, then ultrasonically cleaning the titanium-based implant by using absolute ethyl alcohol for at least 2 minutes, and then ultrasonically cleaning the titanium-based implant by using deionized water for at least 2 minutes.
Compared with the prior art, the invention has the following advantages:
(1) according to the invention, a flexible porous structure layer is constructed on the surface of the titanium-based implant, pores of the flexible porous structure layer are beneficial to bone tissue to grow into the flexible porous structure layer, and a biological composite structure with a nano-pipeline-bone tissue three-dimensional staggered appearance is formed with the nano-pipeline, and the biological composite structure is beneficial to enhancing the bone bonding strength of the implant and an alveolar bone interface;
(2) the construction method of the flexible structure on the surface of the dental implant uses simple NaOH solution treatment, namely, the nano pipeline is formed on the surface of the titanium-based implant by in-situ growth, and the operability is strong;
(3) the main component of the nano pipeline in the flexible structure is Na2Ti2O5And/or Na2Ti3O7The main element components are titanium, oxygen and sodium, and the coating has no toxicity to human bodies and cells;
(4) surface hydrophilic and hydrophobic property tests show that the flexible structure has super-hydrophilic property, and the super-hydrophilic property can enhance the stretching, adsorption and biological activity of bone cells and quickly promote the interface combination between an implant and alveolar bone;
(5) mechanical tests show that the flexible structure has certain elasticity, can absorb energy by 1.59KJ per square centimeter, and has excellent tensile resistance;
(6) tribology tests show that after the flexible structure is added on the surface of the titanium-based implant, the tribology coefficient of the surface of the titanium-based implant cannot be increased, and the planting difficulty of a clinician in the using process cannot be increased.
Drawings
FIG. 1a is an electron microscope image of a longitudinal section of a flexible porous structure layer in example 2, and FIG. 1b is an enlarged view of a dotted-line frame portion on the right side in FIG. 1 a;
2a, 2b and 2c are electron microscope images of cross sections of the flexible porous channel structure layer in example 2 at different magnifications;
FIG. 3 is a schematic structural diagram of a biological composite structure with a three-dimensional staggered morphology of nanotube wires and bone tissue;
FIG. 4a is an X-ray diffraction pattern of the surface of the flexible multi-channel structure layer constructed in example 2, and FIG. 4b is an X-ray diffraction pattern of the surface of the original titanium-based implant without the flexible multi-channel structure layer;
fig. 5a is a test result of the surface hydrophilicity and hydrophobicity of the flexible porous structure layer constructed in example 2, and fig. 5b is a test result of the surface hydrophilicity and hydrophobicity of the original titanium-based implant without the flexible porous structure layer;
fig. 6a, 6b and 6c show the tensile property test results of the flexible porous channel structure layer of example 2 under different loads.
Detailed Description
The invention is described in further detail below with reference to the accompanying examples.
Example 1: the method selects Ti-6Al-4V titanium alloy as a base material of the titanium-based implant, adopts the construction method of the invention to construct and form a flexible multi-pore structure layer on the surface of the titanium-based implant, and the construction method comprises the following steps: carrying out high-temperature treatment on the surface of the titanium-based implant in a closed container by using NaOH solution, wherein the treatment time is at least 1 hour, growing a nano-pipeline on the surface of the titanium-based implant in situ, and constructing a flexible porous structure layer by the nano-pipeline formed by growth, wherein the construction method specifically comprises the following steps:
1) firstly, ultrasonically cleaning a titanium-based implant for 2 minutes by using acetone, ultrasonically cleaning the titanium-based implant for 2 minutes by using absolute ethyl alcohol, ultrasonically cleaning the titanium-based implant for 2 minutes by using deionized water, and naturally drying the titanium-based implant;
2) soaking the titanium-based implant in a closed container filled with NaOH solution with the concentration of 1.0mol/L, and carrying out surface treatment on the titanium-based implant at 230 ℃ for 6 hours to enable a nano-pipeline with the outer diameter of 30-90 nm to grow on the surface of the titanium-based implant in situ, and constructing a flexible porous structure layer with micron-scale pores with the pore diameter of 2-50 microns by the nano-pipeline formed by growth;
3) washing the titanium-based implant treated in the step 2) with deionized water, and naturally drying.
Through detection, the main component of the flexible multi-pore structure layer formed in the example 1 is Na2Ti2O5。
Example 2: the medical titanium TA4 is selected as the base material of the titanium-based implant, and the construction method of the invention is adopted to construct and form the flexible multi-pore structure layer on the surface of the titanium-based implant, and the construction method comprises the following steps: carrying out high-temperature treatment on the surface of the titanium-based implant in a closed container by using NaOH solution, wherein the treatment time is at least 1 hour, growing a nano-pipeline on the surface of the titanium-based implant in situ, and constructing a flexible porous structure layer by the nano-pipeline formed by growth, wherein the construction method specifically comprises the following steps:
1) firstly, ultrasonically cleaning a titanium-based implant for 2 minutes by using acetone, ultrasonically cleaning the titanium-based implant for 2 minutes by using absolute ethyl alcohol, ultrasonically cleaning the titanium-based implant for 2 minutes by using deionized water, and naturally drying the titanium-based implant;
2) soaking the titanium-based implant in a closed container filled with NaOH solution with the concentration of 1.0mol/L, and carrying out surface treatment on the titanium-based implant at 230 ℃ for 12 hours to enable a nano-pipeline with the outer diameter of 30-90 nm to grow on the surface of the titanium-based implant in situ, and constructing a flexible porous structure layer with micron-scale pores with the pore diameter of 2-50 microns by the nano-pipeline formed by growth;
3) washing the titanium-based implant treated in the step 2) with deionized water, and naturally drying.
Electron micrographs of the longitudinal section of the flexible porous structure layer constructed in example 2 are shown in fig. 1a and 1b, and electron micrographs of the cross section of the flexible porous structure layer in example 2 at different magnifications are shown in fig. 2a, 2b, and 2 c. In example 2, after the titanium-based implant is implanted into the alveolar bone, the flexible porous structure layer can promote the combination of the implant and the alveolar bone, so that bone tissue grows into the flexible porous structure, and a biological composite structure with a three-dimensional staggered morphology of a nanotube wire and the bone tissue, which is formed by combining the flexible porous structure and the bone tissue, is formed between the interface of the implant and the alveolar bone, and the structural schematic diagram of the biological composite structure is shown in fig. 3, 1 is the surface of the titanium-based implant, 2 is the surface of the alveolar bone, 3 is the nanotube wire, and 4 is the bone tissue.
The X-ray diffraction pattern of the surface of the flexible porous structure layer constructed in example 2 is shown in fig. 4a (the standard part of the black dots in the figure is a characteristic peak), and the X-ray diffraction pattern of the surface of the original titanium-based implant without the flexible porous structure layer constructed is shown in fig. 4 b. Through detection, the main component of the formed flexible multi-pore structure layer is Na2Ti2O5。
The surface hydrophilicity and hydrophobicity test results of the flexible porous structure layer constructed in example 2 are shown in fig. 5a, and the surface hydrophilicity and hydrophobicity test results of the original titanium-based implant without the flexible porous structure layer are shown in fig. 5 b. Surface hydrophilic and hydrophobic property tests show that the flexible structure has super-hydrophilic property, and the super-hydrophilic property can enhance the stretching, adsorption and biological activity of bone cells and quickly promote the interface combination between an implant and alveolar bone.
Mechanical tests show that the flexible porous channel structure layer in example 2 has certain elasticity, can absorb energy by 1.59KJ per square centimeter, and has excellent tensile resistance. Fig. 6a, 6b and 6c show the tensile property test results of the flexible porous channel structure layer of example 2 under different loads. The test method comprises the following steps: different samples of the flexible porous structure layer of example 2 were tensile tested at normal loads of 300 μ N, 400 μ N, 1000 μ N, respectively, using a nano-scratch tester. Tests show that different samples generate cliff type reduction when the tangential force reaches about 400 mu N, and the tensile strength of the flexible porous channel structure layer can reach 600MPa according to the estimation. This higher tensile strength is favorable to improving the osseointegration intensity at implant and alveolar bone interface, forms the flexible connection structure who has friction buffering barrier propterty of similar natural tooth periodontal membrane at implant and alveolar bone interface, solves implant surface micromotion inefficacy problem, improves long-term stability and the active service life of titanium base implant implantation alveolar bone after, extension implant's life. In addition, tribology tests show that after the flexible structure is added on the surface of the titanium-based implant, the tribology coefficient of the surface of the titanium-based implant cannot be increased, and the planting difficulty of a clinician in the using process cannot be increased.
Claims (8)
1. The flexible structure on the surface of the dental implant is characterized by comprising a flexible porous structure layer constructed by a nano pipeline, wherein the nano pipeline grows on the surface of a titanium-based implant in situ, and the main component of the nano pipeline is Na2Ti2O5And/or Na2Ti3O7。
2. The flexible structure on the surface of a dental implant according to claim 1, wherein the outer diameter of the nanotube wire is 30 to 90 nm.
3. The flexible structure of a dental implant surface according to claim 1, wherein the flexible porous structural layer has pores with a micrometer size when viewed from a cross section of the flexible porous structural layer, and the pore size of the pores is 2 to 50 μm.
4. The flexible structure on the surface of a dental implant according to claim 1, wherein the titanium-based implant is made of pure titanium or titanium alloy.
5. The flexible structure on the surface of a dental implant according to claim 4, wherein said pure titanium is TA4, and said titanium alloy is Ti-6Al-4V, Ti-6Al-7Nb or Ti-3Zr-2Sn-3Mo-25 Nb.
6. A method for constructing a flexible structure on the surface of a dental implant according to any one of claims 1 to 5, wherein the surface of the titanium-based implant is subjected to high temperature treatment in a closed container by using NaOH solution for at least 1 hour, and the nano-tubes are grown in situ on the surface of the titanium-based implant, and then the flexible porous structure layer is constructed by the grown nano-tubes.
7. The method for constructing the flexible structure on the surface of the dental implant according to claim 6, which comprises the following steps:
1) cleaning the titanium-based implant by sequentially adopting acetone, absolute ethyl alcohol and deionized water, and naturally drying;
2) soaking the titanium-based implant in a closed container filled with NaOH solution with the concentration of 0.5-2 mol/L, carrying out surface treatment on the titanium-based implant at 150-240 ℃, wherein the treatment time is 1-24 hours, so that a nano pipeline with the outer diameter of 30-90 nm grows on the surface of the titanium-based implant in situ, and then constructing a flexible porous structure layer with micron-scale pores with the pore diameter of 2-50 mu m by the nano pipeline formed by growth;
3) washing the titanium-based implant treated in the step 2) with deionized water, and naturally drying.
8. The method for constructing the flexible structure on the surface of the dental implant according to claim 7, wherein the cleaning process in the step 1) is as follows: firstly, ultrasonically cleaning a titanium-based implant by using acetone for at least 2 minutes, then ultrasonically cleaning the titanium-based implant by using absolute ethyl alcohol for at least 2 minutes, and then ultrasonically cleaning the titanium-based implant by using deionized water for at least 2 minutes.
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| US20020143403A1 (en) * | 2001-01-02 | 2002-10-03 | Vaidyanathan K. Ranji | Compositions and methods for biomedical applications |
| US20110184529A1 (en) * | 2010-01-28 | 2011-07-28 | Johan Forsgren | Implants Comprising Titanium and Carbonate and Methods of Producing Implants |
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