CN113440586A

CN113440586A - Traditional Chinese medicine for treating skin wound

Info

Publication number: CN113440586A
Application number: CN202110956899.4A
Authority: CN
Inventors: 夏明好
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-08-19
Filing date: 2021-08-19
Publication date: 2021-09-28

Abstract

The invention discloses a traditional Chinese medicine for treating skin wounds, and belongs to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine comprises the following raw materials in parts by weight: 3-11 parts of a traditional Chinese medicine composition and 70-80 parts of absolute ethyl alcohol. The traditional Chinese medicine composition comprises stemona root extract, sanguisorba extract, folium artemisiae argyi extract, cortex moutan extract, fructus cnidii extract, rhizoma atractylodis extract, scutellaria baicalensis extract, gardenia extract, sophora flavescens extract and mint extract. Firstly, in the process of hemostasis, detumescence and anti-inflammation of the wound surface, the detumescence, hemostasis and anti-inflammation functions of the extract are cooperatively exerted, and the effects of rapid analgesia and wound surface sealing are achieved; secondly, the antibacterial effect of the extract is synergistically exerted in the whole process of scabbing and healing of the wound surface, so that the infection of the wound surface is inhibited; thirdly, in the whole process of wound scabbing and healing, the extract plays roles of promoting epidermal blood circulation, resisting oxidation and whitening, promotes scabbing and falling off, and avoids scar generation.

Description

Traditional Chinese medicine for treating skin wound

Technical Field

The invention belongs to the technical field of traditional Chinese medicine pharmacy, and particularly relates to a traditional Chinese medicine for treating skin wounds.

Background

The repair and healing of various injured wounds of human skin are complex pathophysiological processes, namely slight tiny injured wounds, bleeding or exudation of the wounds after injury, dry scabbing and healing under scab. Most of the major or special skin injuries (such as burns) have the problems of exudation, infection, necrotic tissue removal, infection control, wound exudation reduction, scabbing or wound covering by biological materials, and wound healing with scar gradually.

The medicine for treating skin wound in the prior art has no good inhibition effect on exudation of wound tissue fluid, and the exudation of a large amount of tissue fluid of burn and scald patients (especially large-area burn and scald patients) causes electrolyte loss and body fluid imbalance of the patients, thus aggravating the occurrence probability of systemic infection and shock. In addition, most of the existing patent medicines for treating burns and scalds are paste and powder dosage forms, debridement treatment is required when the dosage forms are used for changing the medicines (when the medicines are used for the second time, the debridement process cannot completely remove the medicine oil film coated last time, and certain obstruction is formed for the absorption of the medicine coated again), pain and discomfort of patients are caused in the repeated debridement process, inflammatory exudation of the scalded patients is difficult to remove after being combined with the powder medicine to form scabs, the patients can suffer pain when the medicines are used for debridement and changing the medicines, and even the wound surfaces can be damaged due to the debridement process.

Therefore, the traditional Chinese medicine for treating the skin wound is a spray, does not need debridement treatment, and reduces pain and discomfort of secondary medication of patients.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine for treating skin wounds.

The technical problems to be solved by the invention are as follows: how to prepare a traditional Chinese medicine spray which has antibacterial effect and can inhibit the exudation of wound tissue fluid.

The purpose of the invention can be realized by the following technical scheme:

a traditional Chinese medicine for treating skin wounds comprises the following raw materials in parts by weight: 3-11 parts of a traditional Chinese medicine composition and 70-80 parts of absolute ethyl alcohol.

Further, the traditional Chinese medicine composition is prepared by mixing a stemona root extract, a sanguisorba extract, a folium artemisiae argyi extract, a cortex moutan extract, a fructus cnidii extract, a rhizoma atractylodis extract, a scutellaria baicalensis extract, a gardenia extract, a sophora flavescens extract and a mint extract according to a mass ratio of 9-17:7-12:3-7:3-7:3-7:3-7:3-7:3-7: 3-7.

Stemona is a plant belonging to Stemonaceae, Stemona. The radix Stemonae extract contains radix Stemonae alkaloid as active ingredient, is an alkaloid with pyrrole or pyridine azaanthracene nucleus structure specific to the plant of this family, has pharmacological effects of relieving cough, eliminating phlegm, killing parasite, and resisting bacteria, and can be used for killing parasite, relieving itching, and killing louse. Therefore, when the preparation is used for treating skin wounds, the preparation has an antibacterial effect, and can relieve itching feeling in the process of scabbing of the wounds while inhibiting wound infection and interstitial fluid exudation.

Sanguisorba officinalis is a traditional common traditional Chinese medicine and belongs to rosaceous subfamily of rosaceous. The major active ingredients of sanguisorba are mainly distributed in rhizomes. The main components in the rhizome mainly comprise tannin, phenolic acid, saponin, flavone and polysaccharide, and a small amount of organic acid, steroid and anthraquinone in addition, and the rhizome has good effects of resisting inflammation, relieving swelling, and inhibiting wound infection and tissue fluid exudation.

The folium artemisiae argyi is a traditional Chinese herbal medicine, can be eaten and has very wide effect, and the Ming dynasty Li Shizhen's book of compendium of materia medica' records that: the stem of the seedling of the february perennial root of the argy wormwood leaf is directly grown, white and four or five feet higher. Take moxibustion for even examination. Folium Artemisiae Argyi is used as medicine, and has warm nature, pure yang nature, and effects of dredging twelve meridians, restoring yang, regulating qi and blood, dispelling dampness and cold, stopping bleeding, and preventing miscarriage. So it is also called as cursory medicine. The Chinese medicine powder pottery Hongjing is recorded in famous medical records: the argy wormwood leaves are bitter in taste, slightly warm and nontoxic. Moxibustion is mainly used for treating various diseases, and can be used for decoction, stopping diarrhea, hematemesis, lower part ulcer, female bleeding, benefiting yin qi, promoting granulation, and dispelling wind-cold. And the volatile oil of the argyi leaf is an effective component group of the extract of the argyi leaf and has the effects of resisting bacteria, resisting inflammation, disinfecting, expelling parasites, whitening, stopping bleeding, calming, resisting allergy, suppressing sneezing, relieving itching and the like. The composition can be added into spray for treating wound surface, and has antibacterial, antiinflammatory, disinfectant, and antipruritic effects, and also has skin whitening effect, and can promote wound surface scabbing and scab recovery.

The cortex moutan extract mainly contains paeonol compound, and has synergistic antibacterial effect with flavone and saponin compound.

The fructus Cnidii extract is rich in osthole, and is coumarin compound with typical benzene ring and pyran ring. Osthole has a parent nucleus structure of coumarin and an isopentene structure, and the structural composition of osthole has certain insecticidal and bacteriostatic effects.

The rhizoma atractylodis extract is an rhizoma atractylodis alcohol extract which mainly contains active ingredients such as atractylodin, atractyl alcohol, B-eucalyptol, xanthinol, atractylone, swordlike furanhydrocarbon and the like, has an antibacterial effect on various bacteria, has an antioxidant property and a whitening effect on skin, is added into a spray for treating wound surfaces, reduces the precipitation of melanin after the wound surfaces are healed, and avoids the generation of scars.

Baikal skullcap root, recorded in Shennong Ben Cao Jing (Shennong's herbal), is the dry root of Scutellaria baicalensis Georgi of Labiatae, and its extract has the effects of clearing heat and drying dampness, purging fire and removing toxicity, stopping bleeding and preventing miscarriage. Modern pharmacological research shows that the scutellaria baicalensis extract has antipyretic effect in the pharmacological action processes of resisting inflammation, bacteria, viruses and the like. The composition can be added into spray for treating wound surface, and has hemostatic, antiinflammatory and antibacterial effects on wound surface, so as to inhibit exudation of wound surface tissue fluid.

The fructus Gardeniae extract mainly comprises iridoid and its glycosides, crocin, and organic acids, has effects in purging pathogenic fire, relieving restlessness, clearing away heat, promoting diuresis, cooling blood, removing toxic substances, relieving swelling and pain, and inhibiting Staphylococcus aureus and hemolytic streptococcus.

The radix Sophorae Flavescentis extract is rich in various alkaloids, wherein the matrine has antibacterial and bactericidal effects.

The mint has pharmacological effects of increasing body surface blood circulation, resisting bacteria and viruses, and the like, and the mint extract is added into the spray for treating the wound surface, so that the mint extract has the antibacterial effect on the wound surface, and simultaneously promotes epidermal blood circulation and regeneration.

Therefore, the traditional Chinese medicine extract is selected as the traditional Chinese medicine composition, the antibacterial, anti-inflammatory, itching relieving and regeneration promoting effects of various traditional Chinese medicines are exerted coordinately, the infection of wound bacteria is effectively inhibited, the inflammation is reduced, the fever is relieved, the effusion is stopped, the itching is relieved, the scab is formed, the regeneration is promoted, and the wound is further promoted to be healed as soon as possible.

Further, the folium artemisiae argyi extract is prepared by the following steps:

pulverizing dried folium Artemisiae Argyi, sieving with 50 mesh sieve, adding 8 times of mixed solution of ethanol and deionized water, heating to 96 deg.C, refluxing in water bath for 1.5 hr, repeating for 2 times, mixing extractive solutions, filtering, rotary evaporating, concentrating to dry to obtain folium Artemisiae Argyi extract, and controlling volume ratio of ethanol and deionized water to 3: 1.

Further, the sophora flavescens extract is prepared by the following steps:

pulverizing dried radix Sophorae Flavescentis, sieving with 100 mesh sieve, adding 9-11 times of mixed solvent of acetone and ethanol, soaking for 10 hr, heating to 98 deg.C, refluxing for 2 hr, filtering, collecting filtrate, intercepting filtrate with molecular weight of 5000-10000 by use of ultrafiltration device, rotary evaporating, removing solvent to obtain radix Sophorae Flavescentis extract, and controlling the volume ratio of acetone and ethanol to 2: 1.

Further, the traditional Chinese medicine for treating skin wound is prepared by the following steps:

mixing the traditional Chinese medicine composition with absolute ethyl alcohol, transferring the mixture into a homogenizer, and stirring the mixture for 60-90min at the pressure of 5MPa and the pressure of 700 and 900r/min to obtain the traditional Chinese medicine for treating the skin wound.

The invention has the beneficial effects that:

firstly, in the process of hemostasis, detumescence and anti-inflammation of the wound surface, the invention utilizes the hemostasis and anti-inflammation functions of the scutellaria baicalensis extract, the detumescence function of the sanguisorba extract, the hemostasis and anti-inflammation functions of the artemisia leaf extract and the detumescence and pain-relieving functions of the gardenia extract to cooperatively play the detumescence and anti-inflammation functions of the traditional Chinese medicine extracts, thereby playing the roles of quickly easing pain and quickly sealing the wound surface; secondly, in the whole process of scabbing and healing of the wound surface, the maximum antibacterial effect is coordinately exerted by utilizing the difference of antibacterial mechanisms of the different traditional Chinese medicine extracts, so as to inhibit the infection of the wound surface; thirdly, in the whole process of wound scabbing and healing, the effect of relieving itching of the stemona root extract and the artemisia leaf extract is utilized to relieve the itching feeling of the wound scabbing process; and in the decrustation process, the mint extract with the function of promoting epidermal blood circulation, the rhizoma atractylodis extract with the function of antioxidation, the folium artemisiae argyi extract with the function of whitening, the decrustation of the scab is promoted, and the scar is avoided.

Therefore, the traditional Chinese medicine provided by the invention can be used for treating minor and moderate skin wounds and wounds caused by various reasons, such as burns, scalds, abrasions, chilblains, various sores and furuncles and the like, and has the effects of quickly reducing swelling and relieving pain on the wounds, promoting scabbing and avoiding the generation of scars.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1:

the folium artemisiae argyi extract is prepared by the following steps:

Example 2:

the sophora flavescens extract is prepared by the following steps:

pulverizing dried radix Sophorae Flavescentis, sieving with 100 mesh sieve, adding 9 times of mixed solvent of acetone and ethanol, soaking for 10 hr, heating to 98 deg.C, refluxing for 2 hr, filtering, collecting filtrate, intercepting filtrate with molecular weight of 5000-10000 with ultrafiltration device, rotary evaporating, removing solvent to obtain radix Sophorae Flavescentis extract, and controlling the volume ratio of acetone and ethanol to 2: 1.

Example 3:

a traditional Chinese medicine for treating skin wounds comprises the following raw materials in parts by weight: the traditional Chinese medicine composition comprises 3 parts of a radix stemonae extract, a sanguisorba officinalis extract, a folium artemisiae argyi extract prepared in example 1, a cortex moutan extract, a fructus cnidii extract, a rhizoma atractylodis extract, a scutellaria baicalensis extract, a gardenia jasminoides ellis extract, a radix sophorae flavescentis extract prepared in example 2 and a mint extract which are mixed according to a mass ratio of 9:7:3:3:3:3:3:3:3: 3.

The traditional Chinese medicine for treating skin wound is prepared by the following steps:

mixing the Chinese medicinal composition with anhydrous ethanol, transferring to a homogenizer, and stirring at 5MPa and 900r/min for 60min to obtain the Chinese medicinal composition for treating skin wound.

Example 4:

a traditional Chinese medicine for treating skin wounds comprises the following raw materials in parts by weight: 5.7 parts of a traditional Chinese medicine composition and 75 parts of absolute ethyl alcohol, wherein the traditional Chinese medicine composition is prepared by mixing a radix stemonae extract, a sanguisorba officinalis extract, a folium artemisiae argyi extract prepared in example 1, a cortex moutan extract, a fructus cnidii extract, a rhizoma atractylodis extract prepared in example 2, a scutellaria baicalensis extract and fructus gardeniae 12:10:5:5:5: 5.

mixing the Chinese medicinal composition with anhydrous ethanol, transferring to a homogenizer, and stirring at 5MPa and 800r/min for 70min to obtain the Chinese medicinal composition for treating skin wound.

Example 5:

a traditional Chinese medicine for treating skin wounds comprises the following raw materials in parts by weight: 11 parts of a traditional Chinese medicine composition and 80 parts of absolute ethyl alcohol, wherein the traditional Chinese medicine composition is prepared by mixing a radix stemonae extract, a sanguisorba extract, a folium artemisiae argyi extract prepared in example 1, a cortex moutan extract, a fructus cnidii extract, a rhizoma atractylodis extract, a scutellaria baicalensis extract, a gardenia jasminoides ellis extract, a radix sophorae flavescentis extract prepared in example 2 and a mint extract according to a mass ratio of 17:12:7:7:7:7: 7.

Example 6:

the Chinese medicine obtained in examples 3-5 was used for wound tests:

(1) burn test: the testers, Liji, male, age 35, had arm burns of three degrees.

Details of the burn: the burn wound is hard to endure, the wound surface is full of bubbles with different sizes, part of the bubbles are broken, and a large amount of exudates exist; the dermal tissue is scattered in small-piece whitish and bloodless halo and scattered in small-piece purplish red dermis, and has dull pain sensation of acupuncture and partial painless sensation. The area of the burn and scald is counted, wherein the superficial II degree is 3 percent, the deep II degree is 5 percent, the superficial III degree is 2 percent, and the burn and scald totally occupies 10 percent of the whole area.

Medicine spraying treatment: spraying the traditional Chinese medicine prepared in the example 3 every 1 hour for the first 24 hours, observing the healing condition of the wound surface, and then spraying the traditional Chinese medicine prepared in the example 3 every 2 hours for the next 24 hours; the Chinese medicine prepared in example 3 was then sprayed every 4 hours for 24 hours, and then the Chinese medicine prepared in example 3 was sprayed 3 times a day.

Healing conditions: the tissue fluid of the skin at superficial II degrees stops exudation within 10 hours, scabs within 2 days, and is cured within 5 days; the tissue fluid of 24 hours of the deep II-degree part forms scabs on the skin for 4 days, and the skin is healed in 10 days; the superficial III part with tissue fluid of 36 hours is scabbed for 8 days, and is healed in 18 days; the skin is bright, white and tender after healing.

(2) And (3) scald test: the examinee, Zhang-somewhat, female, aged 28 years, scalded abdomen and thigh to two degrees.

The details of scald are as follows: the scald wound surface is full of bubbles with different sizes, and a part of the bubbles are broken and have a large amount of exudates; and (4) calculating the scald area, wherein the wound depth of the scald area is II degrees and 12 percent.

Medicine spraying treatment: spraying the traditional Chinese medicine prepared in the example 3 every 1 hour for the first 24 hours, observing the healing condition of the wound surface, and then spraying the traditional Chinese medicine prepared in the example 3 every 2 hours for the next 24 hours; the Chinese medicine prepared in example 4 was then sprayed every 4 hours for 24 hours, and then the Chinese medicine prepared in example 3 was sprayed 3 times a day.

Healing conditions: the tissue fluid of the superficial II-degree part of the skin stops exudation after 8 hours, scabs in 2 days, and is healed in 5 days; the skin is bright, white and tender after healing.

(3) Scratch test: subjects, monster, male, age 24, arm bruising.

Details of scratches: 4-5cm²Superficial denudation, blood marks, bleeding or bleeding spots, which may lead to mild inflammatory reactions with localized redness and swelling and pain.

Medicine spraying treatment: the Chinese medicine prepared in example 5 was sprayed 3 times in the first 24 hours, and then the Chinese medicine prepared in example 5 was sprayed 1 time per day.

Healing conditions: 2 hours after the first spraying of the medicine, the swelling is reduced, scabbing is achieved after 12 hours, healing is achieved in 3 days, and the skin is smooth, white and tender after healing.

(5) And (3) chilblain test: the tested person, Pengzhi, female, aged 32 years old, had finger frostbite of two degrees.

Details of frostbite: redness, swelling and congestion of skin, subjective heat, itching and burning pain accompanied by blisters, wherein blood can be contained in the blisters, and edema and severe pain can appear in deep parts of the blisters; the first degree frostbite area is 3 percent, and the second degree frostbite area is 1 percent.

Medicine spraying treatment: spraying the traditional Chinese medicine prepared in the example 3 every 1 hour for the first 24 hours, observing the healing condition of the wound surface, and then spraying the traditional Chinese medicine prepared in the example 3 every 2 hours for the next 24 hours; the Chinese medicine prepared in example 4 was then sprayed every 4 hours for 24 hours, and then the Chinese medicine prepared in example 5 was sprayed 3 times a day.

Healing conditions: the first part of the skin is scabbed for 1 day, and the skin is healed in 4 days; the second part of skin scabs for 4 days and heals in 16 days; the skin is bright, white and tender after healing.

(6) Bedsore test: the testers were old 76 years old and had bedsores on the sacrococcygeal region.

Details of bedsores: the patients lie in bed for a long time to cause the skin at the sacrococcygeal part to be broken, pus is attached to the surface, and the maximum area is 4cm x 6 cm.

Medicine spraying treatment: debridement, spraying the traditional Chinese medicine prepared in example 3 on the wound surface, 5 times a day, and covering with sterile gauze.

Healing conditions: after 7 days, the ulcerated area is obviously reduced, no pus is attached to the surface, pink new meat is generated, after 12 days of continuous use, the bedsore ulcerated part is better healed by about 2 x 3cm, the bedsore is continuously given by the traditional Chinese medicine preparation, after 26 days of use, the bedsore is healed, and the skin is smooth, white and tender after healing.

In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

The foregoing is illustrative and explanatory only and is not intended to be exhaustive or to limit the invention to the precise embodiments described, and various modifications, additions, and substitutions may be made by those skilled in the art without departing from the scope of the invention or exceeding the scope of the claims.

Claims

1. A traditional Chinese medicine for treating skin wounds is characterized in that: the feed comprises the following raw materials in parts by weight: 3-11 parts of a traditional Chinese medicine composition and 70-80 parts of absolute ethyl alcohol;

mixing the Chinese medicinal composition with anhydrous ethanol, and stirring for 60-90min to obtain a Chinese medicinal composition for treating skin wound.

2. The traditional Chinese medicine for treating skin wounds according to claim 1, is characterized in that: the stirring condition is 5MPa, 700 and 900 r/min.

3. The traditional Chinese medicine for treating skin wounds according to claim 1, is characterized in that: the traditional Chinese medicine composition is prepared by mixing a stemona root extract, a sanguisorba officinalis extract, a folium artemisiae argyi extract, a cortex moutan extract, a fructus cnidii extract, a rhizoma atractylodis extract, a scutellaria baicalensis extract, a gardenia extract, a sophora flavescens extract and a mint extract according to a mass ratio of 9-17:7-12:3-7:3-7:3-7:3-7:3-7:3-7:3-7: 3-7.

4. A traditional Chinese medicine for treating skin wounds according to claim 3, which is characterized in that: the folium artemisiae argyi extract is prepared by the following steps:

pulverizing dried folium Artemisiae Argyi, sieving with 50 mesh sieve, adding 8 times of mixed solution of ethanol and deionized water, heating and refluxing, repeating for 2 times, mixing extractive solutions, filtering, rotary evaporating and concentrating to dry to obtain folium Artemisiae Argyi extract.

5. The traditional Chinese medicine for treating skin wounds according to claim 4, is characterized in that: the volume ratio of ethanol to deionized water in the mixed solution was 3: 1.

6. The traditional Chinese medicine for treating skin wounds according to claim 4, is characterized in that: the heating reflux condition is that the reflux is carried out for 1.5h at 96 ℃.

7. A traditional Chinese medicine for treating skin wounds according to claim 3, which is characterized in that: the sophora flavescens extract is prepared by the following steps:

pulverizing dried radix Sophorae Flavescentis, sieving with 100 mesh sieve, adding mixed solvent of acetone and ethanol 9-11 times the mass of radix Sophorae Flavescentis, soaking for 10 hr, heating under reflux, filtering, collecting filtrate, intercepting filtrate with molecular weight of 5000-10000 by use of ultrafiltration device, rotary evaporating, and removing solvent to obtain radix Sophorae Flavescentis extract.

8. The traditional Chinese medicine for treating skin wounds according to claim 7, is characterized in that: the volume ratio of acetone to ethanol in the mixed solvent is 2: 1.

9. The traditional Chinese medicine for treating skin wounds according to claim 7, is characterized in that: the heating reflux condition is heating to 98 ℃ for reflux for 2 h.