CN113440432A - Acne-removing conditioner, acne-removing mask composition and preparation method thereof - Google Patents
Acne-removing conditioner, acne-removing mask composition and preparation method thereof Download PDFInfo
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- CN113440432A CN113440432A CN202110707133.2A CN202110707133A CN113440432A CN 113440432 A CN113440432 A CN 113440432A CN 202110707133 A CN202110707133 A CN 202110707133A CN 113440432 A CN113440432 A CN 113440432A
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- acne
- gel
- oil
- mask composition
- conditioner
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
- A61K2800/882—Mixing prior to application
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- Cosmetics (AREA)
Abstract
The invention relates to an acne-removing conditioner, an acne-removing mask composition and a preparation method thereof, wherein the acne-removing conditioner comprises the following components: 10-20 parts of calamine, 0.1-2 parts of encapsulated salicylic acid, 0.01-0.01 part of oligopeptide-10.001, 0.01-0.32 part of palmitoyl tripeptide-80.001 and 0.1-10 parts of nicotinamide. The acne-removing mask composition consists of 50-95 parts by weight of aqueous medium and 5-25 parts by weight of oil solution gel; wherein the aqueous base comprises an acne-removing conditioner and a gel thickener; the oil solution gel comprises grease and a cross-linking agent. The aqueous medium and the oil gel of the acne-removing mask composition are stored separately, mixed when in use, and then smeared on the face for use, so that the film forming and stripping can be realized, and the product has the advantages of good skin-sticking property, no sensitization and irritation and convenience in use. The preparation method of the acne-removing mask composition is simple and easy to implement, the raw materials are easy to obtain, and the corresponding aqueous medium and oil solution gel can be stored separately and mixed when in use, so that the acne-removing mask composition is suitable for mass production.
Description
Technical Field
The invention relates to the field of daily chemical application, in particular to an acne-removing conditioner, an acne-removing mask composition and a preparation method thereof, and especially relates to a soft mud mask with an acne-removing repairing effect and a preparation method thereof.
Background
Acne, also called "whelk", "pox", "acne" or "comedo-closure", is a skin disease mainly caused by the effects of sebaceous gland hyperfunction, follicular sebaceous gland duct dyskeratosis, and propionibacterium acnes. Androgens cause enlargement of sebaceous glands and increased sebum secretion, and when the reactivity of sebaceous glands increases, it appears to be hyperfunction and secrete a large amount of oil, which is the basis of acne initiation; the duct hyperkeratosis of the pilosebaceous gland (excessive proliferation and differentiation of duct epithelial cells) can cause the mouth of a tube to become small, narrow or blocked, and the normal discharge of epithelial cells and sebum shed from the hair follicle wall is influenced to form acne; the sebum is hydrolyzed into glycerol and free fatty acid under the action of propionibacterium acnes, so that the hair follicle and the periphery of the hair follicle are stimulated to generate nonspecific inflammatory reaction, and inflammatory mediators are induced; in addition, the extravasation of hair follicle contents into the dermis causes deep inflammation of varying degrees around the hair follicle, with a range of clinical manifestations ranging from inflammatory papules to cystic lesions.
The mask is an important skin care product, and the principle of the effect is that the mask is used for temporarily isolating the skin from air, so that the effective ingredients penetrate through the skin as efficiently as possible to play a role. However, the existing facial masks in the market contain more ineffective and harmful components, and can cause different degrees of damage to the skin after long-term use, so that the acne removing and repairing effect cannot be really achieved.
The mask mud is a mud paste type daily use cosmetic for improving the function of facial skin, and compared with the traditional mask, the mask mud has the characteristics of good application property, convenient use, strong moisture retention, good absorption effect and the like. The mask mud contains abundant and balanced minerals, and has effects of diminishing inflammation, sterilizing, removing oil and fat, inhibiting acne deterioration, and making pore more delicate. The minerals and microelements can also supplement nutrition for skin and care skin. However, various facial mask muds appearing in the market at present have poor effects or high price.
Disclosure of Invention
The technical problem to be solved by the invention is to provide an acne-removing conditioner which can effectively remove acnes.
Meanwhile, the invention provides an acne-removing mask composition, which solves the defects of poor acne-removing effect and inconvenience in use of masks in the prior art.
As a first aspect of the invention, the invention provides an acne-removing conditioner which comprises the following components in parts by weight: 10-20 parts of calamine, 0.1-2 parts of encapsulated salicylic acid, 0.01-0.01 part of oligopeptide-10.001, 0.01-0.32 part of palmitoyl tripeptide-80.001 and 0.1-10 parts of nicotinamide.
According to the acne-removing conditioner, the combination of the calamine, the wrapped salicylic acid, the oligopeptide-1, the palmitoyl tripeptide-8 and the nicotinamide is used as the acne-removing conditioner, so that the acne-removing conditioner has a synergistic effect, can effectively remove acnes, and is mild and non-irritant.
As a second aspect of the invention, the invention provides an acne-removing mask composition which comprises, by weight, 50-95 parts of an aqueous medium and 5-25 parts of an oil gel; wherein the aqueous medium matrix comprises an acne-removing conditioner and a gel thickener, and the acne-removing conditioner consists of calamine, encapsulated salicylic acid, oligopeptide-1, palmitoyl tripeptide-8 and nicotinamide; the oil solution gel comprises grease and a cross-linking agent.
In one embodiment, the water aqua matrix comprises, by weight, 10-25% of an acne-removing conditioner and 0.1-5% of a gel thickener; the acne-removing conditioner consists of the following components: 10-20% of calamine, 0.1-2% of encapsulated salicylic acid, 0.01-0.01% of oligopeptide-10.001, 0.1-10% of palmitoyl tripeptide-80.001-0.01% of nicotinamide.
In one embodiment, the gel thickener comprises one or a combination of two or more of sodium alginate, carbomer, carboxymethylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, xanthan gum, gelatin, acacia gum.
In one embodiment, the oil solution gel comprises 50-90% of oil and fat and 1-15% of cross-linking agent by mass percent;
preferably, the grease comprises one or more of caprylic/capric triglyceride, cyclopentadimethylsiloxane, polydimethylsiloxane, cetearyl alcohol, 22 alcohol, ethylhexyl palmitate, stearic acid, shea butter, jojoba oil, macadamia nut oil and squalane;
preferably, the cross-linking agent comprises one or a combination of more than two of alumina, alum, calcium chloride, calcium sulfate and calcium sulfate dihydrate.
In one embodiment, the aqueous base further comprises one or a combination of more than two of a crosslinking regulator, a humectant and a preservative;
the aqueous medium comprises, by mass, 0.01-2% of a crosslinking regulator, 5-25% of a humectant, 0.5-3% of a preservative and 0.01-2% of a chelating agent.
In one embodiment, the crosslinking modifier comprises one or a combination of two or more of disodium hydrogen phosphate, dipotassium hydrogen phosphate, tetrasodium pyrophosphate;
the humectant comprises one or more of glycerol, dipropylene glycol, 1, 3-butanediol, trehalose, xylitol, glyceryl polyether-26, beta-glucan, methyl glucitol polyether-20, methyl glucitol polyether-10, erythrulose, biogum gum-1, rhamnose, oat beta-glucan, acetyl chitosamine, polyethylene glycols, water-soluble oil, water-soluble silicone oil and sodium hyaluronate
In one embodiment, the oil gel further comprises one or a combination of two of an oil phase thickener, an emulsifier; the oil solution gel comprises 0.1-5% of oil phase thickening agent by mass percent; 0.1 to 10 percent of emulsifier.
In one embodiment, the oil phase thickener comprises one or a combination of two or more of glyceryl behenate/eicosoate, polyethylene, ethyl cellulose, fumed silica, dibutyl ethyl hexanoyl glutamine, dibutyl lauroyl glutamine, and the emulsifier comprises polysorbate-60, hydrogenated lecithin, or a combination of two or more thereof.
The acne-removing mask composition provided by the second aspect of the invention comprises an aqueous medium and an oil gel; wherein the addition amount of the aqueous medium is 50-95 parts by mass; the addition amount of the oil solution gel is 5-25 parts by mass.
The aqueous medium and the oil gel in the acne-removing mask composition can be stored separately, and when the acne-removing mask composition is used, the aqueous medium and the oil gel are mixed and then are smeared on the face for use. After mixing for a period of time, the aqueous agent matrix and the oil solution gel can generate cross-linking reaction, a membrane can be formed within 10 minutes, then the membrane can be directly taken down after 15-25 minutes, the facial care can be completed, and the acne-removing mask composition can realize the no-clean function.
The acne-removing mask composition has the advantages of good skin-adhering property, no sensitization and irritation and convenience in use by using the combination of the aqueous medium and the oil solution gel, can realize film forming and stripping by uniformly mixing the aqueous medium and the oil solution gel and then coating the mixture on the face for nursing, and is a washing-free acne-removing gel soft mud mask.
The aqueous medium at least comprises a gel thickening agent and an acne-removing conditioner, so that the aqueous medium and the oil gel can be ensured to have a crosslinking reaction, and the acne-removing mask composition has an acne-removing effect. The acne-removing conditioner comprises, by weight, 10-25% of an acne-removing conditioner matrix and 0.1-5% of a gel thickener.
According to the acne-removing mask composition, the acne-removing conditioner is added, so that the acne-removing mask composition has an excellent acne-removing repairing effect. Particularly, the acne-removing conditioner disclosed by the invention is added into an aqueous medium, so that the efficacy of the acne-removing conditioner can be exerted to the greatest extent in the acne-removing mask composition.
In the invention, the aqueous agent matrix at least comprises the gel thickening agent so as to facilitate the crosslinking reaction of the gel thickening agent and the oil agent matrix. As for the gel thickener, it mainly plays a thickening stabilizing role and a gel film forming role in the present invention. The addition amount of the gel thickener is 0.1-5% by weight of the aqueous agent matrix, such as: 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, etc.; when the content of the gel thickener is too low, the mask has low viscosity, cannot form a stable suspension system and is easy to drip in the use process of the face; when the content of the gel thickening agent is too high, the mask is high in viscosity and sticky in skin feel.
In some specific embodiments, the aqueous base further comprises one or a combination of two or more of a cross-linking modifier, a humectant, a preservative, a chelating agent;
the crosslinking modifier is used mainly for adjusting the pH value and as a retarder for the reaction between the gel thickener and the crosslinking agent in the oil agent. The addition amount of the crosslinking regulator is 0.01-2% based on the weight percentage of the acne-removing mask composition, for example: 0.05%, 0.1%, 0.2%, 0.4%, 0.6%, 0.8%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, etc. If the content of the crosslinking modifier is too low, the stability of the mask dosage form is reduced, and if the content of the crosslinking modifier is too high, the pH value is increased, the gel time is delayed, and the film forming and stripping cannot be realized.
The specific composition of the crosslinking modifier is not particularly limited in the present invention, and may be any crosslinking modifier commonly used in the art. For example: the crosslinking regulator may include one or a combination of two or more of disodium hydrogen phosphate, dipotassium hydrogen phosphate, and tetrasodium pyrophosphate.
The acne-removing mask composition disclosed by the invention has the efficacy of moisturizing by adding the moisturizing agent. Specifically, the adding amount of the humectant is 5-25% by weight of the aqueous medium. When the addition amount of the humectant is 5-25%, the humectant can play a role in moisturizing. Preferably, the humectant of the present invention may be added in an amount of 6 to 24%, may be 8 to 22%, may be 10 to 20%, may be 12 to 18%, may be 14 to 16%, for example: 7%, 9%, 11%, 13%, 15%, 17%, 19%, 21%, 23%, etc. When the content of the humectant is too low, the moisturizing effect is not obvious; when the content of the humectant is too high, the acne-removing mask composition has a sticky feeling.
For example, the humectant may include one or a combination of two or more of glycerin, dipropylene glycol, 1, 3-butylene glycol, trehalose, xylitol, glyceryl polyether-26, β -glucan, methyl gluceth-20, methyl gluceth-10, erythrulose, biosaccharide gum-1, rhamnose, oat β -glucan, acetyl chitosamine, polyethylene glycols, water-soluble oils, water-soluble silicone oils, and sodium hyaluronate.
As for the preservative, the acne-removing mask composition has preservative and antibacterial effects by properly adding some preservatives. Specifically, the adding amount of the humectant is 0.5-3% by weight of the aqueous medium. The amount of the preservative of the present invention added may be 0.8 to 2.8%, may be 1 to 2.5%, may be 1.2 to 2.2%, may be 1.5 to 2%, may be 1.6 to 1.8%, etc. The addition amount of the preservative should not be too large, otherwise sensitization will occur.
For example, the preservative may include one or a combination of two or more of 1, 2-hexanediol, p-hydroxyacetophenone, chlorphenesin, phenoxyethanol, and methylparaben.
The aqueous medium can also contain a chelating agent, and the addition amount of the chelating agent is 0.01-2% by weight of the aqueous medium. The chelating agent may be disodium EDTA-tetrasodium EDTA, etc.
In addition, the aqueous medium of the present invention further contains water, and the content of water is not particularly limited in the present invention, and may be added as needed. The water may be added in an amount of 40-95%, for example: 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, etc.
The oil gel of the present invention comprises an oil and fat and a crosslinking agent.
In the oil, the oil is added into the oil gel, so that the evaporation of water on the surface of the skin can be reduced, and the skin can be prevented from being dried and cracked. By adding oil or fat, a hydrophobic film can be formed on the skin surface to prevent the invasion of harmful substances from the outside. The addition amount of the grease is 50-90% by weight of the oil solution gel, for example: 50%, 52%, 55%, 58%, 60%, 62%, 65%, 68%, 70%, 72%, 75%, 78%, 80%, 82%, 85%, 88%, 90%, etc.; when the content of the oil is too low, evaporation of moisture on the surface of the skin cannot be reduced, and invasion of harmful substances cannot be effectively prevented; when the content of the oil is too high, the acne-removing mask composition is too greasy, and the use feeling is reduced.
For example: the oil comprises one or more of caprylic/capric triglyceride (GTCC), cyclopentadimethylsiloxane, polydimethylsiloxane, cetearyl alcohol, 22 alcohol, ethylhexyl palmitate, stearic acid, shea butter, jojoba oil, macadamia nut oil, and squalane.
The cross-linking agent mainly plays a role of reacting with the gel thickening agent in the water aqua matrix to form gel. In the invention, the addition amount of the cross-linking agent is 1-15% by weight of the oil solution gel, such as: 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, etc. When the content of the crosslinking agent is too low, the mask is hard to coagulate, and when the content of the crosslinking agent is too high, the formed mask substrate is not soft enough, and thus the feeling in use may be reduced.
The oil solution gel can also comprise one or the combination of two of an oil phase thickening agent and an emulsifier.
The oil phase thickener mainly plays a role in stabilizing a system. The addition amount of the oil phase thickener is 0.1-5% by weight of the oil agent gel, such as: 0.3%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 1.8%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, etc. If the content of the oil phase thickener is too low, the thickening effect is poor and the stability is reduced; if the content of the oil phase thickener is too high, the oil phase is solidified into cream, the skin feel is thick and greasy, and the filling of the product is not facilitated.
The oil phase thickener can comprise one or more of glyceryl behenate/eicosanoate, polyethylene, ethyl cellulose, fumed silica, dibutyl ethyl hexanoyl glutamine, dibutyl lauroyl glutamine.
According to the invention, the stability of the oil solution gel is improved by adding the emulsifier. Specifically, the addition amount of the emulsifier is 0.1-10% by weight of the oil solution gel, for example: 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, etc.; when the addition amount of the emulsifier is 0.1-10%, the oil solution gel system is stable. When the dosage of the emulsifier is too low, the emulsifier is not sufficiently emulsified, so that the system is unstable; when the dosage of the emulsifier is too high, the stability of the product can be influenced to a certain extent.
Specifically, the emulsifier of the present invention may include one or a combination of polysorbate-60 and hydrogenated lecithin.
According to the cause of sensitive skin, the acne-removing mask composition with the acne-removing repairing effect is obtained through targeted research, and the acne-removing mask composition consists of an aqueous medium added with components with the acne-removing effect and an oil gel with the skin moistening effect, and has the advantages of good skin-adhering property, no sensitization and irritation and convenience in use.
As a third aspect of the invention, the invention also provides a preparation method of the acne-removing mask composition, which comprises the step of respectively mixing the aqueous base and the oil gel, and mixing the aqueous base and the oil gel when in use to obtain the acne-removing mask composition.
The third aspect of the invention provides a preparation method of the acne-removing mask composition according to the second aspect of the invention, which comprises the step of respectively mixing the aqueous base and the oil gel, and mixing the aqueous base and the oil gel when in use to obtain the acne-removing mask composition.
Specifically, the preparation method comprises the following steps: a step of mixing the components of the aqueous base and a step of mixing the components of the oil gel.
In some specific embodiments, the step for mixing the components of the aqueous base may comprise:
and mixing the gel thickening agent with the acne-removing conditioner to obtain the aqueous medium.
Preferably, the step for mixing the components of the aqueous base may comprise:
dispersing the gel thickener in a portion of the humectant to obtain a swollen product;
adding the crosslinking regulator, the rest humectant and the adsorbent into water, uniformly mixing, and then adding the swelling substance to obtain a premixed system;
adding the acne-removing conditioner and the preservative into a premixing system to obtain the aqueous medium.
Further, the step of mixing the components of the aqueous base may comprise:
dispersing the gel thickener in a part of humectant, and stirring for 5-20min at room temperature by using a stirrer at the rotating speed of 50-250 rpm until the powder is uniformly dispersed to obtain a swelling substance;
adding a proper amount of water into the crosslinking regulator and the rest humectant, raising the temperature to 75-80 ℃, uniformly stirring, slowly adding the obtained swelling substance into the mixture, and stirring at 75-80 ℃ for 10-30min to obtain a premixed system;
reducing the temperature to 40-50 ℃, adding the acne-removing conditioner and the preservative into the obtained premixed system, and uniformly stirring to obtain a soft mud film water agent, wherein the mourning water agent matrix is mourning.
In other specific embodiments, the step of mixing the components of the oil gel may comprise:
and mixing the grease with a cross-linking agent to obtain the oil solution gel.
Preferably, the step of mixing the components of the oil gel may comprise:
mixing the grease and the oil phase thickener to obtain a primary mixture;
and adding an emulsifier and a cross-linking agent into the primary mixture to obtain the oil solution gel.
Further, the step of mixing the components of the oil gel may include:
mixing oil and oil phase thickener, heating to 75-80 deg.C, stirring and dissolving;
reducing the temperature to 40-50 deg.C, adding emulsifier and cross-linking agent into the obtained primary mixture, stirring and homogenizing for 5-20min to obtain oil solution gel.
The invention has the beneficial effects that:
the acne-removing conditioner disclosed by the invention adopts the compatibility of the calamine, the wrapped salicylic acid, the oligopeptide, the palmitoyl tripeptide-8 and the nicotinamide, so that the acne can be effectively removed.
The water aqua matrix and the oil solution gel of the acne-removing mask composition are stored separately, and when the acne-removing mask composition is used, the water aqua matrix and the oil solution gel are mixed and then applied to the face for use, so that film forming and peeling can be realized, the acne-removing mask composition is a wash-free soft gel film, and the acne-removing mask composition has the advantages of good skin adhesion, no sensitization and irritation and convenience in use.
The preparation method of the acne-removing mask composition is simple and easy to implement, the raw materials are easy to obtain, and the corresponding aqueous medium and oil solution gel can be stored separately and mixed when in use, so that the acne-removing mask composition is suitable for mass production.
Detailed Description
Various exemplary embodiments, features and aspects of the invention will be described in detail below. The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.
Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, methods, means, devices and steps which are well known to those skilled in the art have not been described in detail so as not to obscure the invention.
All units used in the specification are international standard units unless otherwise stated, and numerical values and numerical ranges appearing in the present invention should be understood to include systematic errors inevitable in industrial production.
In the present specification, the meaning of "may" includes both the meaning of performing a certain process and the meaning of not performing a certain process.
In the present specification, reference to "some particular/preferred embodiments," "other particular/preferred embodiments," "embodiments," and the like, means that a particular element (e.g., feature, structure, property, and/or characteristic) described in connection with the embodiment is included in at least one embodiment described herein, and may or may not be present in other embodiments. In addition, it is to be understood that the described elements may be combined in any suitable manner in the various embodiments.
In the present specification, the numerical range represented by "numerical value a to numerical value B" means a range including the end point numerical value A, B.
In the present specification, the term "water" includes any available water that can be used in the cosmetic field, such as deionized water, distilled water, ion-exchanged water, double distilled water, high purity water, and purified water.
In the present specification, if "room temperature", "normal temperature" or the like is mentioned, the specific temperature may be 10 to 40 ℃.
Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
Examples 1-2, comparative examples 1-4 and blank controls were prepared according to the following procedure, based on the weight percent (%) of each component in table 1 below:
step 1, cleaning and disinfecting the used production equipment;
step 2, weighing the phase A (gel thickener and partial humectant) raw materials in a separate container, and stirring for 10min at the rotating speed of 200rpm by using a stirrer at room temperature until the powder is uniformly dispersed to obtain a swelling substance;
step 3, taking a proper amount of deionized water, respectively adding the raw materials of the phase B (the crosslinking regulator, the calamine, the residual humectant and the chelating agent), raising the temperature to about 78 ℃, uniformly stirring, slowly adding the swelling material obtained from the phase A, and stirring for 20min at about 78 ℃;
step 4, reducing the temperature to 50 ℃, adding the phase C (part of acne-removing conditioner and preservative) into the system obtained in the step 3, and uniformly stirring to obtain an aqueous medium;
step 5, weighing the phase D (grease and oil phase thickener) according to the mass ratio, mixing and heating to about 78 ℃, and stirring and dissolving uniformly;
and 6, reducing the temperature to 50 ℃, adding the phase E (emulsifier and cross-linking agent) into the primary mixture, and homogenizing and dispersing for 10min to obtain the oil solution gel.
TABLE 1 test formula table
Evaluation of acne removing effect:
the tester: 70 testers (face pox patients, age 16-28 years old) are randomly divided into 7 groups, 10 testers are used in each group, the same formula product is used in each group, and 50g of the formula product is used in the morning and the evening respectively;
use of: twice a day in the morning and at night, and continuously used for one month;
evaluation method: investigating testers;
the using method comprises the following steps: pouring about 50 parts of aqueous base material and about 5 parts of oil solution gel into a mixing vessel, fully mixing for about 30 seconds, uniformly coating the mixed facial mask on the face, and taking down the solidified facial mask after 20 minutes.
The test results are shown in table 2 below.
TABLE 2 test and evaluation table
As a result: as can be seen from table 2, the acne-removing mask composition with synergistic acne-removing effect provided by the invention has a relatively significant acne-removing effect through the synergistic effect of the components of the acne-removing conditioner, and the effect is more obvious than that of a single acne-removing component.
It should be understood that the above embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the same, and those skilled in the art can modify the technical solutions described in the above embodiments, or make equivalent substitutions for some technical features; and all such modifications and alterations are intended to fall within the scope of the appended claims.
Claims (10)
1. The acne-removing conditioner is characterized by comprising the following components in parts by weight: 10-20 parts of calamine, 0.1-2 parts of encapsulated salicylic acid, 0.01-0.01 part of oligopeptide-10.001, 0.01-0.32 part of palmitoyl tripeptide-80.001 and 0.1-10 parts of nicotinamide.
2. The acne-removing mask composition is characterized by comprising 50-95 parts by weight of aqueous medium and 5-25 parts by weight of oil gel; wherein the aqueous medium matrix comprises an acne-removing conditioner and a gel thickener, and the acne-removing conditioner consists of calamine, encapsulated salicylic acid, oligopeptide-1, palmitoyl tripeptide-8 and nicotinamide; the oil solution gel comprises grease and a cross-linking agent.
3. The acne-removing mask composition according to claim 2, which comprises, by weight, 10-25% of an acne-removing conditioner and 0.1-5% of a gel thickener; the acne-removing conditioner consists of the following components: 10-20% of calamine, 0.1-2% of encapsulated salicylic acid, 0.01-0.01% of oligopeptide-10.001, 0.1-10% of palmitoyl tripeptide-80.001-0.01% of nicotinamide.
4. The acne-removing mask composition according to claim 3, wherein the gel thickener comprises one or a combination of two or more of sodium alginate, carbomer, carboxymethyl cellulose, hydroxypropyl methyl cellulose, polyvinyl pyrrolidone, polyvinyl alcohol, xanthan gum, gelatin, acacia gum.
5. The acne-removing mask composition according to claim 2, which is characterized by comprising 50-90% of grease and 1-15% of cross-linking agent by mass percent;
preferably, the grease comprises one or more of caprylic/capric triglyceride, cyclopentadimethylsiloxane, polydimethylsiloxane, cetearyl alcohol, 22 alcohol, ethylhexyl palmitate, stearic acid, shea butter, jojoba oil, macadamia nut oil and squalane;
preferably, the cross-linking agent comprises one or a combination of more than two of alumina, alum, calcium chloride, calcium sulfate and calcium sulfate dihydrate.
6. The acne treatment mask composition according to claim 3, wherein the aqueous base further comprises one or a combination of more than two of a crosslinking regulator, a humectant and a preservative;
the aqueous medium comprises, by mass, 0.01-2% of a crosslinking regulator, 5-25% of a humectant, 0.5-3% of a preservative and 0.01-2% of a chelating agent.
7. The acne treatment mask composition of claim 6 wherein the cross-linking modifier comprises one or a combination of two or more of disodium hydrogen phosphate, dipotassium hydrogen phosphate, tetrasodium pyrophosphate;
the humectant comprises one or a combination of more than two of glycerol, dipropylene glycol, 1, 3-butanediol, trehalose, xylitol, glyceryl polyether-26, beta-glucan, methyl glucitol polyether-20, methyl glucitol polyether-10, erythrulose, biogum gum-1, rhamnose, oat beta-glucan, acetyl chitosamine, polyethylene glycols, water-soluble grease, water-soluble silicone oil and sodium hyaluronate.
8. The acne treatment mask composition according to claim 5, wherein the oil gel further comprises one or a combination of two of an oil phase thickener, an emulsifier; the oil solution gel comprises 0.1-5% of oil phase thickening agent by mass percent; 0.1 to 10 percent of emulsifier.
9. The acne mask composition according to claim 7, wherein the oil phase thickener comprises one or more of glyceryl behenate, polyethylene, ethyl cellulose, fumed silica, dibutyl ethyl hexanoyl glutamine, dibutyl lauroyl glutamine, or a combination of two or more thereof, and the emulsifier comprises polysorbate-60 or hydrogenated lecithin.
10. A method for preparing the acne-removing mask composition according to any one of claims 2-9, which comprises the step of mixing the aqueous base and the oil gel respectively, and mixing the aqueous base and the oil gel when in use to obtain the acne-removing mask composition.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113842344A (en) * | 2021-10-14 | 2021-12-28 | 安徽中美生谷生物科技有限公司 | Skin care product composition with acne removing effect and preparation method thereof |
| CN114983894A (en) * | 2022-06-24 | 2022-09-02 | 广州市婷采化妆品有限公司 | Acne-removing skin care product containing acne-removing composition and preparation method thereof |
| CN115212148A (en) * | 2022-07-22 | 2022-10-21 | 广州睿森生物科技有限公司 | Acne removing composition and application thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060217790A1 (en) * | 2005-03-28 | 2006-09-28 | Ohshin Mlp Co., Ltd. | Sheet-like face pack and kits for face packs |
| CN105232354A (en) * | 2015-11-12 | 2016-01-13 | 赵勤 | Biology-breathable cosmetic mask and preparation method thereof |
| CN107881217A (en) * | 2017-12-12 | 2018-04-06 | 杜立波 | A kind of Moisturizer method for customizing |
| CN108652989A (en) * | 2018-06-27 | 2018-10-16 | 广州科缇生物科技有限公司 | A kind of gel and preparation method thereof with acne-removing |
| CN110075005A (en) * | 2019-06-12 | 2019-08-02 | 广州相宜化妆品有限公司 | Facial mask preformed objects and preparation method thereof and facial mask and facial mask application method |
| CN110664691A (en) * | 2019-11-01 | 2020-01-10 | 北京旋光普利生物医药科技开发有限公司 | Preparation of hydrolat acne-removing mask |
| CN111228153A (en) * | 2020-03-06 | 2020-06-05 | 上海新高姿化妆品有限公司 | Composition with synergistic acne removing effect, cosmetic composition and preparation method thereof |
| CN112402287A (en) * | 2020-11-09 | 2021-02-26 | 浙江湃肽生物有限公司 | Efficient soothing anti-allergy repair polypeptide combination and application thereof |
-
2021
- 2021-06-25 CN CN202110707133.2A patent/CN113440432A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060217790A1 (en) * | 2005-03-28 | 2006-09-28 | Ohshin Mlp Co., Ltd. | Sheet-like face pack and kits for face packs |
| CN105232354A (en) * | 2015-11-12 | 2016-01-13 | 赵勤 | Biology-breathable cosmetic mask and preparation method thereof |
| CN107881217A (en) * | 2017-12-12 | 2018-04-06 | 杜立波 | A kind of Moisturizer method for customizing |
| CN108652989A (en) * | 2018-06-27 | 2018-10-16 | 广州科缇生物科技有限公司 | A kind of gel and preparation method thereof with acne-removing |
| CN110075005A (en) * | 2019-06-12 | 2019-08-02 | 广州相宜化妆品有限公司 | Facial mask preformed objects and preparation method thereof and facial mask and facial mask application method |
| CN110664691A (en) * | 2019-11-01 | 2020-01-10 | 北京旋光普利生物医药科技开发有限公司 | Preparation of hydrolat acne-removing mask |
| CN111228153A (en) * | 2020-03-06 | 2020-06-05 | 上海新高姿化妆品有限公司 | Composition with synergistic acne removing effect, cosmetic composition and preparation method thereof |
| CN112402287A (en) * | 2020-11-09 | 2021-02-26 | 浙江湃肽生物有限公司 | Efficient soothing anti-allergy repair polypeptide combination and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 希芸: "堪比"一键美颜"的祛痘神器，了解一下", 《SYRINX希芸官方号》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113842344A (en) * | 2021-10-14 | 2021-12-28 | 安徽中美生谷生物科技有限公司 | Skin care product composition with acne removing effect and preparation method thereof |
| CN114983894A (en) * | 2022-06-24 | 2022-09-02 | 广州市婷采化妆品有限公司 | Acne-removing skin care product containing acne-removing composition and preparation method thereof |
| CN115212148A (en) * | 2022-07-22 | 2022-10-21 | 广州睿森生物科技有限公司 | Acne removing composition and application thereof |
| CN115212148B (en) * | 2022-07-22 | 2023-08-11 | 广州睿森生物科技有限公司 | Acne removing composition and application thereof |
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Application publication date: 20210928 |