CN113368371A - Medicine carrying balloon for preventing and treating benign stricture of esophagus - Google Patents
Medicine carrying balloon for preventing and treating benign stricture of esophagus Download PDFInfo
- Publication number
- CN113368371A CN113368371A CN202110618136.9A CN202110618136A CN113368371A CN 113368371 A CN113368371 A CN 113368371A CN 202110618136 A CN202110618136 A CN 202110618136A CN 113368371 A CN113368371 A CN 113368371A
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- China
- Prior art keywords
- balloon
- esophagus
- preventing
- drug
- loaded
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1042—Alimentary tract
- A61M2210/105—Oesophagus
Abstract
The invention relates to a drug-loaded balloon for preventing and treating benign stricture of esophagus, belonging to the technical field of medical instruments. Comprises a balloon and an inflation tube, wherein the balloon is connected with the inflation tube, and the surface of the balloon is coated with a paclitaxel layer. The invention provides a drug-loaded balloon for preventing and treating esophageal ESD postoperative stenosis, provides a technical means for clinically and systematically treating esophageal ESD postoperative stenosis, and solves the clinical urgent need of people suffering from the disease. Meanwhile, the industrial development of the related degradable drug-loaded material can be promoted. The invention has simple and reliable structure, low cost, easy production, great clinical significance and convenient popularization and application.
Description
Technical Field
The invention relates to a drug-loaded balloon for preventing and treating benign stricture of esophagus, belonging to the technical field of medical instruments.
Background
The esophagus cancer is a high-incidence digestive tract tumor in China, and according to statistics of cancer data in 2015, the number of new cases of esophagus cancer in China exceeds half of the total new cases in the world, and is one of the top five lethal tumors in China. In recent years, the popularization of NBI (narrow band imaging) amplified endoscopic technology, ESD (endoscopic submucosal dissection) technology and early cancer screening of the digestive tract are benefited, so that the early diagnosis and treatment of esophageal cancer in China are greatly improved. The ESD is a technology for removing early cancer in an endoscope digestive tract, has the characteristics of safety, minimally invasion and the like on the basis of ensuring clean incisional margin, and researches show that the ESD has similar survival benefit compared with surgical operation on esophageal mucosal cancer. Benign stricture after esophageal lesion endoscopy operation, which is brought along with the popularization of ESD, is increased year by year. Due to the lumen structure of the esophagus, for patients with large-scale mucosal dissection, the physiological scar repair process of the patients often causes irreversible luminal stenosis and further causes serious eating difficulty, and different researches show that the probability of significant stenosis of ESD patients with the esophagus for more than half a week is about 70% -90% under the condition of no intervention measures, and the stenosis degree is positively correlated with the dissection radius range. Although the cases are not malignant diseases, the patients basically lose labor capacity due to the fact that the patients cannot eat or even enter water, family care and even venous nutrition maintenance are needed, meanwhile, the survival expectation of the patients is far greater than that of the patients with the malignant diseases, so that more social medical resources are consumed in the course of the disease, and some patients finally have to perform gastrostomy, and the life of the patients is prolonged. If the esophageal stenosis after the ESD operation can be properly solved, the part of people can regain the health without damage, so that the health is completely integrated into the social life of normal people. Therefore, the technical problem of how to prevent and treat postoperative esophageal ESD stenosis is urgently needed to be solved in the technical field.
Disclosure of Invention
The invention aims to solve the technical problem of how to prevent and treat postoperative stenosis of esophageal ESD.
In order to solve the problems, the technical scheme is to provide the drug-loaded balloon for preventing and treating benign esophageal stenosis, which comprises a balloon and an inflation tube, wherein the balloon is connected with the inflation tube, and the surface of the balloon is coated with a paclitaxel layer.
Preferably, the balloon is provided as an elastic hollow body.
Preferably, the surface of the balloon is coated with a detachable magnesium stearate matrix layer; paclitaxel is disposed in the magnesium stearate matrix layer.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a drug-loaded balloon for preventing and treating esophageal ESD postoperative stenosis, provides practical experience for clinically and systematically treating esophageal ESD postoperative stenosis, and solves the clinical urgent need of people suffering from the disease. Meanwhile, the industrial development of the related degradable drug-loaded material can be promoted. The invention has simple and reliable structure, low cost, easy production, great clinical significance and convenient popularization and application.
Drawings
FIG. 1 is a schematic view of the structure of the present invention.
Reference numerals: 1. a balloon; 2. and an inflation tube.
Detailed Description
In order to make the invention more comprehensible, preferred embodiments are described in detail below with reference to the accompanying drawings:
the technical scheme provided by the invention is to provide a drug-loaded balloon for preventing and treating benign stricture of esophagus, which comprises a balloon 1 and an inflation tube 2, wherein the balloon 1 is connected with the inflation tube 2, and a paclitaxel layer is coated on the surface of the balloon 1. The balloon is an elastic hollow body. The surface of the balloon is coated with a detachable magnesium stearate matrix layer; paclitaxel is disposed in the magnesium stearate matrix layer.
The surface of the drug-loaded balloon provided by the invention is covered with paclitaxel, and the magnesium stearate is used as a matrix to help paclitaxel to quickly permeate to a narrow wound surface. The balloon size was 18mm diameter, 40mm length of a conventional cylindrical balloon.
With the popularization of the endoscopic diagnosis and treatment technology, esophageal tumor lesions can be treated more and more through endoscopic submucosal dissection, but the problem of esophageal stenosis caused by the esophageal tumor lesions becomes a main contradiction which affects the quality of life of patients after operation, and the esophageal tumor lesions are not healed for a long time, and in turn, the deep development and popularization of endoscopic diagnosis and treatment are also affected. Meanwhile, benign strictures of the esophagus, such as benign strictures of an anastomotic stoma after esophageal cancer operation in thoracic surgery, inflammatory strictures caused by chemical burns of the esophagus due to mistaken eating of strong acid and strong base, which are more common in rural areas, are also problems to be solved clinically. With the development of new materials and new technologies, the invention can be used for preventing and treating benign stricture of the esophagus. Simple and reliable structure, low cost, easy production, great clinical significance and convenient popularization and application.
Examples
The invention can be used for esophagus ESD operation, and drug balloon administration after specimen is cut off, so as to prevent benign stricture from forming. It can also be used in cases where benign stenosis has developed, by direct balloon dilatation and administration.
Aiming at the benign stricture case of the esophagus or the case that the esophagus is possibly narrowed, the drug-carrying balloon is sent under a gastroscope clamp channel, the balloon is expanded and inflated, the surface of the balloon is attached to the target wound surface for about 2-5min, and the balloon is removed after the drug is fully contacted with the target wound surface.
While the invention has been described with respect to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention. Those skilled in the art can make various changes, modifications and equivalent arrangements, which are equivalent to the embodiments of the present invention, without departing from the spirit and scope of the present invention, and which may be made by utilizing the techniques disclosed above; meanwhile, any changes, modifications and variations of the above-described embodiments, which are equivalent to those of the technical spirit of the present invention, are within the scope of the technical solution of the present invention.
Claims (3)
1. A medicine carrying balloon for preventing and treating benign stricture of esophagus is characterized in that: comprises a balloon and an inflation tube, wherein the balloon is connected with the inflation tube, and the surface of the balloon is coated with a paclitaxel layer.
2. The drug-loaded balloon for preventing and treating benign stricture of the esophagus as claimed in claim 1, wherein: the balloon is provided as an elastic hollow body.
3. The drug-loaded balloon for preventing and treating benign stricture of the esophagus as claimed in claim 2, wherein: the surface of the balloon is coated with a detachable magnesium stearate matrix layer; paclitaxel is disposed in the magnesium stearate matrix layer.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110618136.9A CN113368371A (en) | 2021-06-03 | 2021-06-03 | Medicine carrying balloon for preventing and treating benign stricture of esophagus |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110618136.9A CN113368371A (en) | 2021-06-03 | 2021-06-03 | Medicine carrying balloon for preventing and treating benign stricture of esophagus |
Publications (1)
Publication Number | Publication Date |
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CN113368371A true CN113368371A (en) | 2021-09-10 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN202110618136.9A Pending CN113368371A (en) | 2021-06-03 | 2021-06-03 | Medicine carrying balloon for preventing and treating benign stricture of esophagus |
Country Status (1)
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CN (1) | CN113368371A (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102512747A (en) * | 2011-12-27 | 2012-06-27 | 微创医疗器械(上海)有限公司 | Medicine eluting balloon catheter |
CN104922784A (en) * | 2015-07-01 | 2015-09-23 | 乐普(北京)医疗器械股份有限公司 | Drug balloon catheter |
CN112439122A (en) * | 2019-09-05 | 2021-03-05 | 尤东侠 | Balloon dilatation catheter |
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2021
- 2021-06-03 CN CN202110618136.9A patent/CN113368371A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102512747A (en) * | 2011-12-27 | 2012-06-27 | 微创医疗器械(上海)有限公司 | Medicine eluting balloon catheter |
CN104922784A (en) * | 2015-07-01 | 2015-09-23 | 乐普(北京)医疗器械股份有限公司 | Drug balloon catheter |
CN112439122A (en) * | 2019-09-05 | 2021-03-05 | 尤东侠 | Balloon dilatation catheter |
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RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210910 |
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RJ01 | Rejection of invention patent application after publication |