CN113365969A - 含有邻苯二甲醛的连接体及其用于制备抗体-药物缀合物的用途 - Google Patents
含有邻苯二甲醛的连接体及其用于制备抗体-药物缀合物的用途 Download PDFInfo
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- CN113365969A CN113365969A CN201980076936.3A CN201980076936A CN113365969A CN 113365969 A CN113365969 A CN 113365969A CN 201980076936 A CN201980076936 A CN 201980076936A CN 113365969 A CN113365969 A CN 113365969A
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- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
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- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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Abstract
Description
ADC | 抗体药物缀合物 |
DAR | 药物抗体比 |
DMA | 二甲基乙酰胺 |
HPLC | 高效液相色谱法 |
SEC | 尺寸排阻色谱法 |
LC-MS | 液相色谱法-质谱法 |
UV-vis | UV-可见光分光光度计 |
eq | 当量 |
TFA | 三氟乙酸 |
IPA | 异丙醇 |
EDTA | 乙二胺四乙酸 |
Claims (20)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2018117257 | 2018-11-23 | ||
CNPCT/CN2018/117257 | 2018-11-23 | ||
PCT/CN2019/119884 WO2020103891A1 (en) | 2018-11-23 | 2019-11-21 | ortho-Phthalaldehyde containing linkers and use for preparation of antibody-drug conjugate |
Publications (2)
Publication Number | Publication Date |
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CN113365969A true CN113365969A (zh) | 2021-09-07 |
CN113365969B CN113365969B (zh) | 2023-09-15 |
Family
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CN201980076936.3A Active CN113365969B (zh) | 2018-11-23 | 2019-11-21 | 含有邻苯二甲醛的连接体及其用于制备抗体-药物缀合物的用途 |
Country Status (4)
Country | Link |
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US (1) | US20220017462A1 (zh) |
EP (1) | EP3883914A4 (zh) |
CN (1) | CN113365969B (zh) |
WO (1) | WO2020103891A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112778380A (zh) * | 2019-11-06 | 2021-05-11 | 成都先导药物开发股份有限公司 | 一种合成On-DNA叠氮化合物的方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2024041521A1 (en) * | 2022-08-26 | 2024-02-29 | The University Of Hong Kong | Compositions and methods for constructing conjugates |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104877982A (zh) * | 2015-05-11 | 2015-09-02 | 香港大学深圳研究院 | 制备肽/蛋白缀合物的方法和试剂 |
CN105899526A (zh) * | 2013-12-17 | 2016-08-24 | 诺华股份有限公司 | 细胞毒性肽和其缀合物 |
CN108472273A (zh) * | 2015-09-11 | 2018-08-31 | 波利艾克蒂瓦有限公司 | 包含生物活性剂的聚合物缀合物 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102482320B (zh) * | 2009-08-12 | 2013-10-23 | 李学臣 | 丝氨酸和苏氨酸位的天然化学连接 |
-
2019
- 2019-11-21 CN CN201980076936.3A patent/CN113365969B/zh active Active
- 2019-11-21 US US17/296,088 patent/US20220017462A1/en active Pending
- 2019-11-21 WO PCT/CN2019/119884 patent/WO2020103891A1/en unknown
- 2019-11-21 EP EP19887512.2A patent/EP3883914A4/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105899526A (zh) * | 2013-12-17 | 2016-08-24 | 诺华股份有限公司 | 细胞毒性肽和其缀合物 |
CN104877982A (zh) * | 2015-05-11 | 2015-09-02 | 香港大学深圳研究院 | 制备肽/蛋白缀合物的方法和试剂 |
CN108472273A (zh) * | 2015-09-11 | 2018-08-31 | 波利艾克蒂瓦有限公司 | 包含生物活性剂的聚合物缀合物 |
Non-Patent Citations (2)
Title |
---|
CHUN LING TUNG等: "Traceless and Chemoselective Amine Bioconjugation via Phthalimidine Formation in Native Protein Modification", 《ORGANIC LETTERS》 * |
YANLI MA等: "Design and synthesis ofortho-phthalaldehyde phosphoramidite for single-step, rapid, efficient and chemoselective coupling of DNA with proteins under physiological conditions", 《CHEM. C OMMUN.》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112778380A (zh) * | 2019-11-06 | 2021-05-11 | 成都先导药物开发股份有限公司 | 一种合成On-DNA叠氮化合物的方法 |
Also Published As
Publication number | Publication date |
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EP3883914A4 (en) | 2022-04-06 |
US20220017462A1 (en) | 2022-01-20 |
EP3883914A1 (en) | 2021-09-29 |
CN113365969B (zh) | 2023-09-15 |
WO2020103891A1 (en) | 2020-05-28 |
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