CN113332485A - Antibacterial patch and preparation method thereof - Google Patents

Antibacterial patch and preparation method thereof Download PDF

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Publication number
CN113332485A
CN113332485A CN202110571657.3A CN202110571657A CN113332485A CN 113332485 A CN113332485 A CN 113332485A CN 202110571657 A CN202110571657 A CN 202110571657A CN 113332485 A CN113332485 A CN 113332485A
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Prior art keywords
antibacterial
layer
patch
sensitive adhesive
antimicrobial
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Inventor
唐志虎
王静儒
骆小红
徐会杰
王宠
高甲
赵义丽
程媛
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China Lucky Group Corp
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China Lucky Group Corp
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Priority to CN202110571657.3A priority Critical patent/CN113332485A/en
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Priority to PCT/CN2021/133120 priority patent/WO2022247183A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

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  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention discloses an antibacterial patch and a preparation method thereof. The antibacterial patch comprises a supporting layer, an antibacterial material layer, an antibacterial adhesive layer and an isolation layer. The antibacterial material layer is formed on at least part of the surface of the support layer; the antibacterial glue layer is formed on at least part of the surface of the antibacterial material layer far away from the supporting layer; the isolation layer is formed on at least part of the surface of the bacteriostatic glue layer far away from the antibacterial material layer. The antibacterial patch has the double functions of inhibiting bacterial growth and sterilizing, can realize long-term antibacterial sterilization and rapid wound healing, and has the advantages of long effective period, safety, reliability, good comfort, low usage amount of the antibacterial agent, low production cost and wide market prospect.

Description

Antibacterial patch and preparation method thereof
Technical Field
The invention relates to the field of medicine and rehabilitation, in particular to an antibacterial patch and a preparation method thereof.
Background
The antibacterial material is a novel functional material which has the function of killing or inhibiting microorganisms, and an antibacterial substance (called as an antibacterial agent) is added into the material, so that the material has the capability of inhibiting or killing bacteria on the surface. At present, various antibacterial plastics, antibacterial fibers, antibacterial ceramics, antibacterial steel and the like are on the market and are widely applied to different fields.
In many fields such as medicine, harmful bacteria have great harm to human bodies, and especially, antibacterial dressings are needed to be used on skin parts such as wounds or traumas to prevent bacterial infection and secondary touch injury. It is well known that bacteria of different metabolic types require different conditions for growth and propagation, but most require growth and propagation in an environment with proper temperature, sufficient moisture and rich organic matter. The wound provides a good environment for bacterial breeding, satisfies a plurality of conditions of bacterial growth, easily causes bacterial infection, consequently in the in-service use, the wound healing under the adhesive bandage often need be later than without the adhesive bandage because the gas permeability of adhesive bandage is poor, and wound moisture can not go out under the adhesive bandage, leads to bacterial infection, is difficult for healing. Therefore, there is a need in the market for an antimicrobial patch that has high antimicrobial activity, is highly breathable at the wound, prevents bacteria from forming on the wound, reduces water content, promotes wound healing, accelerates cell growth, and has fewer negative effects.
The existing antibacterial dressing technology has two development directions, one is that the antibacterial agent is added into the adhesive layer to directly form an antibacterial effect at the skin contact position, for example, an antibacterial hemostatic wound dressing, but because the air permeability is poor, the wound is difficult to heal, and the antibacterial dressing technology is mainly used for quickly stopping bleeding and preventing bacterial breeding in a short period. Secondly, the antibacterial agent is dispersed on the non-woven fabric or copper fiber containing antibacterial materials and the like are adopted, and due to the fact that the air impermeability of the adhesive layer is poor in antibacterial effect on the wound, a porous antibacterial patch appears, but bacteria easily infect the bacteria through the pores, and therefore the pressure-sensitive adhesive and other modes are often needed to resist the bacteria on the wound, and therefore the antibacterial effect is not good. In addition, the two antibacterial modes only solve the bactericidal effect, do not consider the problem of how to prevent bacteria from breeding, and cannot well solve the problems of skin sweating, blood and the like, so that the antibacterial dressing can breed bacteria. In addition, the coating of the antibacterial agent by the glue layer not only reduces the effect and increases the dosage of the antibacterial agent, but also influences the performance of the glue. If the glue layer and the non-woven fabric are both provided with the antibacterial agent, the raw material cost and the manufacturing cost of the product are greatly increased, and a plurality of patents and products can achieve long-term effects by increasing the dosage of the antibacterial agent.
In summary, the existing antibacterial patches still need to be improved.
Disclosure of Invention
The present invention is directed to solving, at least to some extent, one of the technical problems in the related art. Therefore, the invention aims to provide an antibacterial patch and a preparation method thereof. The antibacterial patch has the double functions of inhibiting bacterial growth and sterilizing, can realize long-term antibacterial sterilization and rapid wound healing, and has the advantages of long effective period, safety, reliability, good comfort, low usage amount of the antibacterial agent, low production cost and wide market prospect.
In one aspect of the invention, an antimicrobial patch is provided. According to an embodiment of the present invention, the antibiotic sticker includes: the antibacterial material layer is formed on at least part of the surface of the support layer; the antibacterial material layer is formed on at least part of the surface, far away from the supporting layer, of the antibacterial material layer; the isolation layer, the isolation layer is formed at least partial surface that the antibacterial glue layer is kept away from the antibacterial material layer.
According to the antibacterial patch disclosed by the embodiment of the invention, the supporting layer has directionality, is good in comfort when being in contact with the skin, and can play a role in promoting blood circulation and accelerating inflammation recovery to a certain extent. The antibacterial material is attached to one surface of the supporting layer, and is not in contact with the skin in the using process, so that the antibacterial component is not lost, other side effects such as allergy and the like are not easy to cause, and the safety is greatly improved. The antibacterial adhesive layer is compounded on the antibacterial material layer, so that on one hand, the adhesive force of the antibacterial material can be enhanced, the antibacterial material is not easy to fall off, firm and durable, bacteria are prevented from contacting the surface of the skin, and a high-efficiency antibacterial effect is achieved; on the other hand, the antibacterial adhesive layer has good air permeability, can realize the rapid and natural recovery of sweat, blood or serum exuded from wounds and the like, keeps the skin dry and comfortable, and inhibits the growth of bacteria. Therefore, the antibacterial patch has the functions of inhibiting bacterial growth and sterilizing, can realize long-term antibacterial sterilization and rapid wound healing, and has the advantages of long validity period, safety, reliability, good comfort, low usage amount of the antibacterial agent, low production cost and wide market prospect.
In addition, the antibacterial patch according to the above embodiment of the present invention may further have the following additional technical features:
in some embodiments of the present invention, the elastic ratio of the elastic material is 1.2 to 2.5.
In some embodiments of the present invention, the antibacterial material layer contains organic-inorganic composite antibacterial silver, and the content of the organic-inorganic composite antibacterial silver is not higher than 0.05 wt%.
In some embodiments of the invention, the bacteriostatic adhesive layer is a pressure sensitive adhesive layer having patterned breathable voids.
In some embodiments of the present invention, the pressure-sensitive adhesive layer is formed of at least one of a rubber-type pressure-sensitive adhesive, an acrylic pressure-sensitive adhesive, and a silicone pressure-sensitive adhesive.
In some embodiments of the present invention, the spacing between the patterned air-permeable voids is 5-10 mm.
In some embodiments of the invention, the patterned air-permeable voids are a curvilinear pattern.
In some embodiments of the present invention, the release layer is a release paper or a release film.
In another aspect of the present invention, the present invention provides a method of manufacturing the antibiotic patch of the above embodiment. According to an embodiment of the invention, the method comprises: forming an antibacterial material layer on the surface of the supporting layer by using an antibacterial material coating liquid, and forming an antibacterial adhesive layer on the surface of the side, coated with the silicone oil, of the isolating layer by using a pressure-sensitive adhesive coating liquid; and compounding the antibacterial material layer and the antibacterial adhesive layer to obtain the antibacterial patch. Therefore, the antibacterial patch of the embodiment can be simply, conveniently and efficiently prepared by the method, and is easy for large-scale production.
In addition, the method for preparing the antibacterial patch according to the above embodiment of the present invention may further have the following additional technical features:
in some embodiments of the present invention, the bacteriostatic glue layer is patterned in advance before the antibacterial material layer is compounded with the bacteriostatic glue layer.
In some embodiments of the present invention, the bacteriostatic adhesive layer is moved along a straight line, and the patterning is performed by using a reciprocating scraper, wherein a moving direction of the scraper is perpendicular to a moving direction of the bacteriostatic adhesive layer.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
fig. 1 is a schematic structural view of an antimicrobial patch according to an embodiment of the present invention.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The examples, where specific techniques or conditions are not indicated, are to be construed according to the techniques or conditions described in the literature in the art or according to the product specifications. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.
In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.
In one aspect of the invention, an antimicrobial patch is provided. Referring to fig. 1, according to an embodiment of the present invention, the antibiotic sticker includes: the antibacterial plastic film comprises a supporting layer 1, an antibacterial material layer 2, an antibacterial adhesive layer 3 and an isolating layer 4. The antibacterial material layer 2 is formed on at least part of the surface of the support layer 1; the bacteriostatic glue layer 3 is formed on at least part of the surface of the antibacterial material layer 2 far away from the support layer 1; the isolation layer 4 is formed on at least part of the surface of the bacteriostatic glue layer 3 far away from the antibacterial material layer 2.
The following further describes in detail the antibiotic patch according to an embodiment of the present invention.
According to the embodiment of the present invention, the specific kind of the support layer 1 is not particularly limited as long as it has good air permeability, and for example, cotton cloth or other air permeability-modified material or the like may be used. The good air permeability can ensure that the moisture content of the skin surface layer is in a normal level, and bacteria are not easy to breed.
In addition, the fiber gaps of the material of the supporting layer are large, so that the antibacterial surface area can be increased, the antibacterial effect can be enhanced, and meanwhile, the loss of the antibacterial material on the material can be reduced. More preferably, the support layer 1 is selected from elastic materials having good breathability. In addition, according to actual needs, a waterproof function, a fragrance function and the like can be added to the support layer 1.
According to some embodiments of the present invention, the elastic material used for the support layer 1 has an elasticity ratio of 1.2 to 2.5. This provides a more directional support layer 1 and better comfort in contact with the skin.
According to some embodiments of the present invention, the antibacterial material layer 2 contains the organic-inorganic composite antibacterial silver, and the content of the organic-inorganic composite antibacterial silver is not more than 0.05 wt%, for example, may be 0.05 wt%, 0.04 wt%, 0.03 wt%, 0.02 wt%, 0.01 wt%, 0.005 wt%, etc., whereby the antibacterial effect of the antibacterial body may be further improved. Alternatively, the antimicrobial material layer may be formed by applying an antimicrobial finish commonly used in the art (e.g., CSA-I antimicrobial finish, etc.) to the support layer 1.
According to some embodiments of the present invention, the antibacterial adhesive layer 3 is preferably a pressure-sensitive adhesive layer (3 a in fig. 1) having patterned air-permeable gaps, wherein the patterned air-permeable gaps can ensure the air-permeable performance of the antibacterial patch as a whole and fix the antibacterial material on the support layer 1.
The specific kind of the above pressure-sensitive adhesive layer is not particularly limited and can be selected by those skilled in the art according to actual needs. According to some embodiments of the present invention, the pressure-sensitive adhesive layer may be formed of at least one of rubber-type pressure-sensitive adhesive, acrylic pressure-sensitive adhesive, silicone pressure-sensitive adhesive.
According to some embodiments of the present invention, the pitch of the patterned air-permeable voids may be 5 to 10mm, such as 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, and the like. The inventor finds that by controlling the distance between the patterned air-permeable gaps within the range, better matching between the air permeability of the adhesive layer and the bonding property of the product can be realized; if the space between the patterned air-permeable gaps is too small, the area of the glue layer in the lines is too small, and the coating is easy to fall off from the base layer; if the spacing of the patterned breathable voids is too large, it may result in a decrease in the breathability of the product, increasing the likelihood of skin irritation.
According to some embodiments of the invention, the patterned air-permeable voids are a curvilinear pattern, preferably sinusoidal or quasi-sinusoidal. Therefore, the air permeability of the pressure sensitive adhesive layer is maximized and the contact with the skin is more uniform.
According to some embodiments of the present invention, the release layer may be a release paper or a release film. From this, can protect pressure-sensitive adhesive layer, avoid pressure-sensitive adhesive layer and dust contact in the air to lead to becoming invalid, it is more convenient during the use moreover.
In another aspect of the present invention, the present invention provides a method of manufacturing the antibiotic patch of the above embodiment. According to an embodiment of the invention, the method comprises: forming an antibacterial material layer on the surface of the supporting layer by using an antibacterial material coating liquid, and forming an antibacterial adhesive layer on the surface of one side of the isolating layer coated with the silicone oil by using a pressure-sensitive adhesive; and compounding the antibacterial material layer with the antibacterial adhesive layer to obtain the antibacterial patch.
The method of preparing the antibiotic patch according to the embodiment of the present invention is further described in detail below.
First, according to an embodiment of the present invention, an antibacterial material layer is formed on the surface of a support layer using an antibacterial material coating liquid. Specifically, the antibacterial material coating liquid may adopt an antibacterial finishing agent (such as CSA-I antibacterial finishing agent) commonly used in the art, and then dried for standby.
Further, according to the embodiment of the present invention, the bacteriostatic adhesive layer is formed on the surface of the side of the release layer coated with the silicone oil by using the pressure-sensitive adhesive coating liquid.
According to some embodiments of the present invention, the bacteriostatic adhesive layer is patterned in advance before the antibacterial material layer is combined with the bacteriostatic adhesive layer. Specifically, the bacteriostatic adhesive layer can be patterned by the reciprocating scraper through enabling the bacteriostatic adhesive layer to move along a straight line, wherein the moving direction of the scraper is perpendicular to the moving direction of the bacteriostatic adhesive layer. Therefore, the scraper can scrape sinusoidal curves or quasi-sinusoidal curves on the antibacterial glue layer in the swinging process, so that patterned air-permeable gaps are formed.
Further, after patterning is finished, drying the antibacterial adhesive layer with the patterned air-permeable gaps at 50-130 ℃ to volatilize a solvent in the antibacterial adhesive layer, so as to obtain stable dry adhesive.
Further, according to the embodiment of the invention, the antibacterial material layer and the antibacterial adhesive layer are compounded to obtain the antibacterial patch product.
Further, the rolled antibacterial paste can be cut into required sizes or shapes according to actual requirements.
In summary, the antimicrobial patch of the present invention may have at least one of the following advantages:
(1) the antibacterial patch is a physical antibacterial patch, not only can obtain a high-efficiency antibacterial effect by adopting a high-efficiency silver antibacterial material, but also can be adsorbed on porous fibers to strengthen the antibacterial effect.
(2) Through compounding with the pressure-sensitive adhesive, the nano silver has strong bonding fastness, and a non-missing all-round sterilization layer can be realized. The good air permeability of the supporting layer and the pressure-sensitive adhesive layer enables the moisture content of the surface layer of the skin to be in a normal level, and bacteria are not easy to breed.
(3) When the antibacterial patch is used for one time, the usage amount of the antibacterial agent can be greatly reduced on the premise of having the same effect as the existing product.
(4) The antibacterial patch disclosed by the invention is good in human body comfort, simple in manufacturing process, low in cost, small in side effect, and applied to the field of wound dressing and the like, can provide a high-efficiency antibacterial space, can carry out long-term bacteriostasis and sterilization, can volatilize blood and clear liquid at a wound in time, enables the wound to heal more easily, and is wide in product applicability and good in market prospect.
The invention will now be described with reference to specific examples, which are intended to be illustrative only and not to be limiting in any way.
Example 1
Coating an antibacterial material coating liquid on one side of the cotton elastic cloth (the elasticity ratio is 2.0), wherein the antibacterial material coating liquid is an aqueous solution containing 0.5% of CSA-I antibacterial finishing agent (organic-inorganic composite silver antibacterial agent), the content of silver particles is 0.01%, drying in a drying oven at 100 ℃ for 4min, and cooling for later use.
On a production line, the release paper is operated at a certain speed, one side of the release paper coated with silicone oil is uniformly coated with a layer of medical pressure-sensitive adhesive coating liquid, in the process that the release paper coated with adhesive moves forwards, a crankshaft or an eccentric wheel which moves back and forth is transversely arranged on the adhesive surface to drive a metal sheet or a plastic sheet in an irregular comb tooth shape to transversely move on the adhesive surface, and the adopted comb needle is oval, the long axis is 2mm, and the short axis is 1mm so as to pattern the pressure-sensitive adhesive.
The isolation paper with the patterned pressure-sensitive adhesive layer is sent into a drying tunnel, dried and volatilized at a high temperature of 120 ℃, a solvent in the pressure-sensitive adhesive is removed, stable dry adhesive is obtained and attached to the isolation paper, the antibacterial layer surface elastic cloth is compounded with the adhesive side of the isolation paper with the adhesive, and the rolled antibacterial paste is cut into the required size or shape according to the requirements of products.
Example 2
Coating an antibacterial material coating liquid on one side of the medical non-woven fabric, wherein the antibacterial material coating liquid is an aqueous solution containing 0.5% of CSA-I antibacterial finishing agent (organic-inorganic composite silver antibacterial agent), wherein the content of silver particles is 0.01%, drying for 4min in a 100 ℃ oven, and cooling for later use.
On a production line, the release paper is operated at a certain speed, one side of the release paper coated with silicone oil is uniformly coated with a layer of medical pressure-sensitive adhesive coating liquid, in the process that the release paper coated with adhesive moves forwards, a crankshaft or an eccentric wheel which moves back and forth is transversely arranged on the adhesive surface to drive a metal sheet or a plastic sheet in an irregular comb tooth shape to transversely move on the adhesive surface, and the adopted comb needle is oval, the long axis is 2mm, and the short axis is 1mm so as to pattern the pressure-sensitive adhesive.
The isolation paper with the patterned pressure-sensitive adhesive layer is sent into a drying tunnel, dried and volatilized at a high temperature of 120 ℃, a solvent in the pressure-sensitive adhesive is removed, stable dry adhesive is obtained and attached to the isolation paper, the antibacterial layer surface elastic cloth is compounded with the adhesive side of the isolation paper with the adhesive, and the rolled antibacterial paste is cut into the required size or shape according to the requirements of products.
Test example
The antibiotic properties of the antibiotic patches prepared in examples 1 and 2 were measured according to the "Disinfection specifications" and the results are shown in Table 1.
TABLE 1 antibacterial Property test results
Figure BDA0003082936010000071
The test results show that the antibacterial patches of the embodiment 1 and the embodiment 2 have good antibacterial effect. The antibacterial patch using the cotton stretch fabric of example 1 is superior to the antibacterial patch using the non-stretch nonwoven fabric of example 2 in view of the comfort of human skin. The antibacterial patch using the cotton elastic cloth is more suitable for realizing the antibacterial environment of large wounds, and the antibacterial patch using the non-elastic non-woven cloth is more suitable for realizing the antibacterial environment of small wounds.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.

Claims (10)

1. An antimicrobial patch, comprising:
a support layer, a first electrode and a second electrode,
the antibacterial material layer is formed on at least part of the surface of the support layer;
the antibacterial material layer is formed on at least part of the surface, far away from the supporting layer, of the antibacterial material layer;
the isolation layer, the isolation layer is formed at least partial surface that the antibacterial glue layer is kept away from the antibacterial material layer.
2. The antimicrobial patch according to claim 1, wherein the support layer is made of an elastic material, and the elastic ratio of the elastic material is 1.2-2.5.
3. The antimicrobial patch according to claim 1, wherein the antimicrobial material layer contains organic-inorganic composite antimicrobial silver, and the content of the organic-inorganic composite antimicrobial silver is not higher than 0.05 wt%.
4. The antibacterial patch according to claim 1, wherein the antibacterial adhesive layer is a pressure-sensitive adhesive layer with patterned air-permeable gaps;
optionally, the pressure-sensitive adhesive layer is formed of at least one of rubber-type pressure-sensitive adhesive, acrylic pressure-sensitive adhesive, silicone pressure-sensitive adhesive.
5. The antimicrobial patch according to claim 4, wherein the spacing between the patterned air-permeable gaps is 5-10 mm.
6. The antimicrobial patch of claim 4, wherein the patterned air-permeable voids are a curvilinear pattern.
7. The antimicrobial patch according to claim 1, wherein the release layer is release paper or release film.
8. A method for preparing the antibacterial patch according to any one of claims 1 to 7, which comprises the following steps:
forming an antibacterial material layer on the surface of the supporting layer by using an antibacterial material coating liquid, and forming an antibacterial adhesive layer on the surface of the side, coated with the silicone oil, of the isolating layer by using a pressure-sensitive adhesive coating liquid;
and compounding the antibacterial material layer and the antibacterial adhesive layer to obtain the antibacterial patch.
9. The method according to claim 8, wherein the bacteriostatic glue layer is patterned in advance before the antibacterial material layer is compounded with the bacteriostatic glue layer.
10. The method according to claim 9, wherein the bacteriostatic adhesive layer is moved along a straight line, and the patterning is performed by using a reciprocating scraper, wherein the moving direction of the scraper is perpendicular to the moving direction of the bacteriostatic adhesive layer.
CN202110571657.3A 2021-05-25 2021-05-25 Antibacterial patch and preparation method thereof Pending CN113332485A (en)

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