CN113332341A - Processing method of white paeony root and white paeony root processed product - Google Patents

Processing method of white paeony root and white paeony root processed product Download PDF

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CN113332341A
CN113332341A CN202110683137.1A CN202110683137A CN113332341A CN 113332341 A CN113332341 A CN 113332341A CN 202110683137 A CN202110683137 A CN 202110683137A CN 113332341 A CN113332341 A CN 113332341A
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white paeony
roots
steaming
white
processing method
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张立军
张旭
王艳玲
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Hebei Xuyu Jinkun Pharmaceutical Co ltd
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Hebei Xuyu Jinkun Pharmaceutical Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/13Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/17Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting

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  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to a processing method of white paeony root and a white paeony root processed product, wherein the method comprises the following steps: step 1, selecting fresh white paeony roots, cleaning, and removing heads, tails and fibrous roots; step 2, soaking the cleaned white paeony roots in water for 3-6 hours; step 3, placing the soaked white paeony roots into a steaming container, and steaming in a waterproof way; and 4, taking out the steamed white paeony roots, removing the outer skins, slicing, and naturally airing to obtain the white paeony roots. The processed product of the white paeony root contains paeoniflorin, and the mass content of the paeoniflorin is more than or equal to 2.4 percent. The processed product of white peony root prepared by the method of the invention has obviously improved effective components.

Description

Processing method of white paeony root and white paeony root processed product
Technical Field
The invention belongs to the field of traditional Chinese medicine processing, and particularly relates to a processing method of white paeony root and a white paeony root processed product.
Background
The use of Paeonia has a long history, and Paeonia is recorded in Shen nong Ben Cao Jing and listed as a Chinese-grade product. After Tang and Song, the peony is divided into red peony root and white peony root. Paeonia lactiflora pall has been used as radix Paeoniae alba and radix Paeoniae Rubra respectively in modern medicine. Radix Paeoniae alba is dried root of Paeonia lactiflora Pall of Ranunculaceae with cortex removed. Radix paeoniae alba has the effects of nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain and calming liver yang, and is collected in the section of 2020 edition Chinese pharmacopoeia.
At present, the processing of white paeony root generally comprises the following methods: 1) raw white peony root: cleaning radix Paeoniae alba, moistening, slicing, and drying; 2) white peony root processed with wine: parching radix Paeoniae alba tablet with wine to slight yellow. The specific operation is as follows: stirring 0.1kg of yellow wine for every 1kg of radix Paeoniae alba, standing, moistening, placing in a pan after the wine is absorbed completely, and parching with slow fire to slight yellow; 3) parching radix Paeoniae alba: parching radix Paeoniae alba slice to slight yellow; 4. vinegar processed white peony root: mixing the radix Paeoniae alba tablet with a certain amount of rice vinegar, stirring, placing 0.2kg of rice vinegar for each 1kg of radix Paeoniae alba, moistening, placing into a pan after the vinegar is absorbed completely, and parching with slow fire to slight yellow.
Because the active ingredient paeoniflorin of the white paeony root is unstable, when the white paeony root is processed by adopting the method, the content of the paeoniflorin is obviously reduced, more effective active substances (such as paeonol, benzoylpaeoniflorin and albiflorin) are lost, and the white paeony root has poor mouthfeel, bitter taste and poor clinical effect.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a method for processing white paeony root and a white paeony root processed product.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the first technical scheme is as follows:
a processing method of radix paeoniae alba comprises the following steps:
step 1, selecting fresh white paeony roots, cleaning, and removing heads, tails and fibrous roots;
step 2, soaking the cleaned white paeony roots in water for 3-6 hours;
step 3, placing the soaked white paeony roots into a steaming container, and steaming in a waterproof way;
and 4, taking out the steamed white paeony roots, removing the outer skins, slicing, and naturally airing to obtain the white paeony roots.
Further, in step 2, the dosage ratio of white peony root to water during infiltration is 1 g: 5-20 mL.
Further, in step 3, a steamer is adopted as the steaming container.
Further, in step 3, the water in the steaming container is heated to boiling, and then the white paeony root is added into the steaming container.
Furthermore, in the steaming process in the step 3, the pressure of the steaming container is 1.0-3.0 kg cm < -2 >, and the steaming time is 20-40 minutes.
The second technical scheme is as follows:
a radix Paeoniae alba processed product contains paeoniflorin, and the mass content of the paeoniflorin is not less than 2.4%.
Further, the paeonol composition also comprises paeonol, benzoylpaeoniflorin and albiflorin, wherein the mass content of the paeonol is more than or equal to 1.9%; the mass content of the benzoylpaeoniflorin is more than or equal to 1.8 percent; the mass content of the albiflorin is more than or equal to 1.9 percent.
Compared with the prior art, the invention has the following beneficial effects:
the invention has simple and easy process, is convenient to control the processing links, can ensure the stable quality of the processed products, and is suitable for industrial production.
The invention adopts the soaking and steaming method to process the white paeony root medicinal material, and adopts boiling water for feeding during steaming, compared with the traditional white paeony root processing method, the white paeony root medicinal material adopts 1.0-3.0 kg cm-2The pressure water-proof steaming not only does not cause the loss of the active ingredient of the albiflorin, but also improves the content of the albiflorin, achieves the purpose of synergy, is beneficial to the development of Chinese medicinal materials, and has popularization prospect and practical significance.
The processed radix paeoniae alba product prepared by the method has the advantages that the content of the albiflorin is more than or equal to 2.4 percent, and the mass content of the paeonol is more than or equal to 1.9 percent; the mass content of the benzoylpaeoniflorin is more than or equal to 1.8 percent; the mass content of the albiflorin is more than or equal to 1.9 percent, the effective components are obviously improved, and the effects of enhancing the drug effect of the white paeony root decoction pieces and improving the curative effect of the traditional Chinese medicine formula can be achieved.
Detailed Description
Example 1
A processing method of radix paeoniae alba comprises the following steps:
step 1, selecting fresh white paeony roots, cleaning, and removing heads, tails and fibrous roots;
step 2, according to the dosage ratio of the white paeony root to the water of 1 g: 12mL, soaking the cleaned white paeony root in water for 3 hours;
step 3, placing the soaked white paeony roots into a steaming container, and steaming in a waterproof way; the method specifically comprises the following steps:
heating water in steaming container to boil, placing radix Paeoniae alba in steaming container, and pressurizing to 1.5kg cm-2Steaming for 20 minutes after the pressure is reduced;
and 4, taking out the steamed white paeony roots, removing the outer skins, slicing, and naturally airing to obtain the white paeony roots.
Example 2
A processing method of radix paeoniae alba comprises the following steps:
step 1, selecting fresh white paeony roots, cleaning, and removing heads, tails and fibrous roots;
step 2, according to the dosage ratio of the white paeony root to the water of 1 g: 6mL, soaking the cleaned white paeony root in water for 4.5 hours;
step 3, placing the soaked white paeony roots into a steaming container, and steaming in a waterproof way; the method specifically comprises the following steps:
heating water in steaming container to boil, placing radix Paeoniae alba in steaming container, and pressurizing to 2.0kg cm-2Steaming for 30 minutes after the pressure is reduced;
and 4, taking out the steamed white paeony roots, removing the outer skins, slicing, and naturally airing to obtain the white paeony roots.
Example 3
A processing method of radix paeoniae alba comprises the following steps:
step 1, selecting fresh white paeony roots, cleaning, and removing heads, tails and fibrous roots;
step 2, according to the dosage ratio of the white paeony root to the water of 1 g: soaking the cleaned white paeony roots in 18mL of water for 6 hours;
step 3, placing the soaked white paeony roots into a steaming container, and steaming in a waterproof way; the method specifically comprises the following steps:
heating water in steaming container to boil, placing radix Paeoniae alba in steaming container, and pressurizing to 3.0kg cm-2Steaming for 40 minutes after the pressure of (3);
and 4, taking out the steamed white paeony roots, removing the outer skins, slicing, and naturally airing to obtain the white paeony roots.
Comparative example 1
A processing method of radix paeoniae alba comprises the following steps:
step 1, selecting fresh white paeony roots, cleaning, and removing heads, tails and fibrous roots;
step 2, according to the dosage ratio of the white paeony root to the water of 1 g: 12mL, soaking the cleaned white paeony root in water for 6 hours;
and 3, taking out the white paeony roots, removing the outer skins, slicing, and naturally drying to obtain the white paeony roots.
Comparative example 2
White peony root: removing rhizome, fibrous root and silt, and drying in the sun.
Comparative example 3
White peony root decoction pieces: removing impurities, separating, cleaning, moistening, slicing, and drying.
Example of effects:
the content of the effective components of the processed white paeony root products prepared in the examples and the comparative examples is measured, and the result is shown in the table 1:
the test method comprises the following steps:
the sample pretreatment method comprises the following steps: taking 100g of white paeony root, crushing, and sieving with a 80-mesh sieve to obtain white paeony root powder; then taking 0.1g of white paeony root powder, precisely weighing, placing in a 50ml measuring flask, adding 35ml of diluted ethanol, carrying out ultrasonic treatment (power 240W and frequency 45kHz) for 30 minutes, cooling, adding the diluted ethanol to the scale, shaking up, filtering, and taking the subsequent filtrate to obtain a sample solution for later use;
the determination method of the albiflorin comprises the following steps: high performance liquid chromatography;
chromatographic conditions are as follows: a chromatographic column using octadecylsilane chemically bonded silica as a filler; acetonitrile-0.1% phosphoric acid solution (14:86) is used as a mobile phase; the detection wavelength is 230 nm;
preparation of control solutions: taking a proper amount of paeoniflorin reference substance, precisely weighing, and adding methanol to prepare a solution containing 60 μ g of paeoniflorin per 1 mL;
the determination method comprises precisely sucking 10 μ L of each of the reference solution and the sample solution, injecting into a liquid chromatograph, and determining.
The determination method of paeonol comprises the following steps: the chromatographic conditions were as above. Taking a proper amount of paeonol reference substance, precisely weighing, and adding methanol to obtain a solution containing 5 μ g of paeonol per 1 mL. The measurement method is the same as above.
The determination method of the benzoylpaeoniflorin comprises the following steps: the chromatographic conditions were as above. Taking a proper amount of benzoylpaeoniflorin reference substance, precisely weighing, and adding methanol to obtain a solution containing 10 μ g of benzoylpaeoniflorin per 1 mL. The measurement method is the same as above.
The method for measuring the albiflorin comprises the following steps: the chromatographic conditions were as above. Taking a proper amount of albiflorin reference substance, precisely weighing, and adding methanol to obtain a solution containing 100 μ g of albiflorin per 1 mL. The measurement method is the same as above.
TABLE 1
Figure BDA0003123452950000041
The embodiments described above are only preferred embodiments of the invention and are not exhaustive of the possible implementations of the invention. Any obvious modifications to the above would be obvious to those of ordinary skill in the art, but would not bring the invention so modified beyond the spirit and scope of the present invention.

Claims (7)

1. The processing method of the white paeony root is characterized by comprising the following steps:
step 1, selecting fresh white paeony roots, cleaning, and removing heads, tails and fibrous roots;
step 2, soaking the cleaned white paeony roots in water for 3-6 hours;
step 3, placing the soaked white paeony roots into a steaming container, and steaming in a waterproof way;
and 4, taking out the steamed white paeony roots, removing the outer skins, slicing, and naturally airing to obtain the white paeony roots.
2. The processing method of white peony root according to claim 1,
in step 2, the dosage ratio of white peony root to water during infiltration is 1 g: 5-20 mL.
3. The processing method of white peony root according to claim 1, wherein in step 3, the steaming vessel is a steamer.
4. The processing method of radix paeoniae alba as claimed in claim 1, wherein in step 3, the water in the steaming container is heated to boiling, and then the radix paeoniae alba is added into the steaming container.
5. The processing method of radix paeoniae alba as claimed in claim 1, wherein in the steaming process of step 3, the pressure of the steaming container is 1.0-3.0 kg-cm-2And the steaming time is 20-40 minutes.
6. A processed radix paeoniae alba product processed by the processing method of any one of claims 1 to 5, which contains paeoniflorin with the content of more than or equal to 2.4%.
7. The processed radix paeoniae alba product according to claim 6, further comprising paeonol, benzoylpaeoniflorin and albiflorin, wherein the content of the paeonol is more than or equal to 1.9%; the content of the benzoylpaeoniflorin is more than or equal to 1.8 percent; the content of albiflorin is more than or equal to 1.9%.
CN202110683137.1A 2021-06-21 2021-06-21 Processing method of white paeony root and white paeony root processed product Pending CN113332341A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114191472A (en) * 2021-12-30 2022-03-18 南昌大学 Processing method of traditional Chinese medicine white paeony root

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108210581A (en) * 2018-03-25 2018-06-29 长春人民药业集团有限公司 A kind of radix paeoniae rubrathe processed product and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108210581A (en) * 2018-03-25 2018-06-29 长春人民药业集团有限公司 A kind of radix paeoniae rubrathe processed product and preparation method thereof

Non-Patent Citations (1)

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Title
***: "白芍饮片中芍药苷含量低于中国药典标准的探讨", 《首都医药》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114191472A (en) * 2021-12-30 2022-03-18 南昌大学 Processing method of traditional Chinese medicine white paeony root
CN114191472B (en) * 2021-12-30 2022-09-16 南昌大学 Processing method of traditional Chinese medicine white paeony root

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