CN113316818A - 新生抗原的鉴定方法 - Google Patents

新生抗原的鉴定方法 Download PDF

Info

Publication number
CN113316818A
CN113316818A CN202080008090.2A CN202080008090A CN113316818A CN 113316818 A CN113316818 A CN 113316818A CN 202080008090 A CN202080008090 A CN 202080008090A CN 113316818 A CN113316818 A CN 113316818A
Authority
CN
China
Prior art keywords
tumor
sequencing
gene
mutation
somatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202080008090.2A
Other languages
English (en)
Other versions
CN113316818B (zh
Inventor
姜宁
张文宏
田晔
仇超
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trace Biomedical Technology Xiamen Co Ltd
Original Assignee
Mark Zhun Biotechnology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mark Zhun Biotechnology Co ltd filed Critical Mark Zhun Biotechnology Co ltd
Publication of CN113316818A publication Critical patent/CN113316818A/zh
Application granted granted Critical
Publication of CN113316818B publication Critical patent/CN113316818B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids

Landscapes

  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

本发明涉及肿瘤免疫治疗的领域。具体而言,本发明提供了患者中肿瘤特异性新生抗原的鉴定方法和装置。通过本发明的方法或装置鉴定的新生抗原可用于开发针对所述肿瘤的疫苗或T细胞疗法。

Description

PCT国内申请,说明书已公开。

Claims (26)

  1. PCT国内申请,权利要求书已公开。
CN202080008090.2A 2019-03-15 2020-03-13 新生抗原的鉴定方法 Active CN113316818B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910198582.1A CN111696628A (zh) 2019-03-15 2019-03-15 新生抗原的鉴定方法
CN2019101985821 2019-03-15
PCT/CN2020/079131 WO2020187143A1 (zh) 2019-03-15 2020-03-13 新生抗原的鉴定方法

Publications (2)

Publication Number Publication Date
CN113316818A true CN113316818A (zh) 2021-08-27
CN113316818B CN113316818B (zh) 2024-04-02

Family

ID=72475381

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201910198582.1A Pending CN111696628A (zh) 2019-03-15 2019-03-15 新生抗原的鉴定方法
CN202080008090.2A Active CN113316818B (zh) 2019-03-15 2020-03-13 新生抗原的鉴定方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201910198582.1A Pending CN111696628A (zh) 2019-03-15 2019-03-15 新生抗原的鉴定方法

Country Status (2)

Country Link
CN (2) CN111696628A (zh)
WO (1) WO2020187143A1 (zh)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170016075A1 (en) * 2015-07-14 2017-01-19 Personal Genome Diagnostics, Inc. Neoantigen analysis
WO2017024006A1 (en) * 2015-08-03 2017-02-09 The Johns Hopkins University Personalized, allogeneic cell therapy of cancer
US20170199961A1 (en) * 2015-12-16 2017-07-13 Gritstone Oncology, Inc. Neoantigen Identification, Manufacture, and Use
CN107636162A (zh) * 2015-06-01 2018-01-26 加利福尼亚技术学院 用针对特定群体的抗原筛选t细胞的组合物和方法
CN107704727A (zh) * 2017-11-03 2018-02-16 杭州风起智能科技有限公司 基于肿瘤新抗原特征值的新抗原活性预测和排序方法
CN108388773A (zh) * 2018-02-01 2018-08-10 杭州纽安津生物科技有限公司 一种肿瘤新生抗原的鉴定方法
CN108491689A (zh) * 2018-02-01 2018-09-04 杭州纽安津生物科技有限公司 基于转录组的肿瘤新抗原鉴定方法
WO2018183544A1 (en) * 2017-03-31 2018-10-04 Dana-Farber Cancer Institute, Inc. Method for identification of retained intron tumor neoantigens from patient transcriptome

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108796055B (zh) * 2018-06-12 2022-04-08 深圳裕策生物科技有限公司 基于二代测序的肿瘤新生抗原检测方法、装置和存储介质
CN109021062B (zh) * 2018-08-06 2021-08-20 倍而达药业(苏州)有限公司 一种肿瘤新抗原的筛选方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107636162A (zh) * 2015-06-01 2018-01-26 加利福尼亚技术学院 用针对特定群体的抗原筛选t细胞的组合物和方法
US20170016075A1 (en) * 2015-07-14 2017-01-19 Personal Genome Diagnostics, Inc. Neoantigen analysis
WO2017024006A1 (en) * 2015-08-03 2017-02-09 The Johns Hopkins University Personalized, allogeneic cell therapy of cancer
US20170199961A1 (en) * 2015-12-16 2017-07-13 Gritstone Oncology, Inc. Neoantigen Identification, Manufacture, and Use
CN108601731A (zh) * 2015-12-16 2018-09-28 磨石肿瘤生物技术公司 新抗原的鉴别、制造及使用
WO2018183544A1 (en) * 2017-03-31 2018-10-04 Dana-Farber Cancer Institute, Inc. Method for identification of retained intron tumor neoantigens from patient transcriptome
CN107704727A (zh) * 2017-11-03 2018-02-16 杭州风起智能科技有限公司 基于肿瘤新抗原特征值的新抗原活性预测和排序方法
CN108388773A (zh) * 2018-02-01 2018-08-10 杭州纽安津生物科技有限公司 一种肿瘤新生抗原的鉴定方法
CN108491689A (zh) * 2018-02-01 2018-09-04 杭州纽安津生物科技有限公司 基于转录组的肿瘤新抗原鉴定方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JEANNE MENEZ-JAMET等: "Optimized tumor cryptic peptides: the basis for universal neoantigen- like tumor vaccines", ANNALS OF TRANSLATIONAL MEDICINE, vol. 14, no. 4, 22 April 2016 (2016-04-22), pages 1 - 11 *
高志博等: "肿瘤精准免疫治疗与基因检测", 生物产业技术, vol. 02, 28 February 2017 (2017-02-28), pages 27 - 33 *

Also Published As

Publication number Publication date
WO2020187143A1 (zh) 2020-09-24
CN111696628A (zh) 2020-09-22
CN113316818B (zh) 2024-04-02

Similar Documents

Publication Publication Date Title
JP7530455B2 (ja) 新生抗原の特定、製造、及び使用
EP2872653B1 (en) Personalized cancer vaccines and adoptive immune cell therapies
TWI765875B (zh) 新抗原辨識、製造及用途
CN108796055B (zh) 基于二代测序的肿瘤新生抗原检测方法、装置和存储介质
JP7034931B2 (ja) ネオエピトープのウイルス送達のための改善された組成物および方法ならびにその使用
JP2019513021A (ja) ネオエピトープ提示のための配列の配置および配列
JP2019511907A (ja) 癌免疫療法の治療標的としての患者特異的ネオエピトープのハイスループット同定
KR20240023699A (ko) 바이러스성 암 네오에피토프를 위한 조성물 및 방법
TW201908491A (zh) 腫瘤抗原性加工和呈遞
US20210284738A1 (en) Ranking system for immunogenic cancer-specific epitopes
US20190287656A1 (en) Viral neoepitopes and uses thereof
CN113316818B (zh) 新生抗原的鉴定方法
EP4419716A1 (en) Cancer neoantigens
US20220296642A1 (en) Methods of Making Therapeutic T Lymphocytes
US20230197192A1 (en) Selecting neoantigens for personalized cancer vaccine
EA046410B1 (ru) Иммуногенетическая скрининговая проба на рак

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right

Effective date of registration: 20220816

Address after: Unit 202-1, No. 817, Lianting Road, Xiang'an District, Xiamen City, Fujian Province

Applicant after: Trace Biomedical Technology (Xiamen) Co., Ltd.

Address before: 14 / F, far east development building, 121 Des Voeux Road Central, Hong Kong, China

Applicant before: Mark Zhun Biotechnology Co.,Ltd.

TA01 Transfer of patent application right
GR01 Patent grant
GR01 Patent grant