CN113274012A - Noninvasive blood gas monitoring device and noninvasive closed-loop monitoring system for in-vivo and in-vitro blood - Google Patents
Noninvasive blood gas monitoring device and noninvasive closed-loop monitoring system for in-vivo and in-vitro blood Download PDFInfo
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- CN113274012A CN113274012A CN202110706911.6A CN202110706911A CN113274012A CN 113274012 A CN113274012 A CN 113274012A CN 202110706911 A CN202110706911 A CN 202110706911A CN 113274012 A CN113274012 A CN 113274012A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14557—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted to extracorporeal circuits
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Abstract
The invention discloses a noninvasive blood gas monitoring device and an in vivo and in vitro blood noninvasive closed-loop monitoring system. Monitoring devices and external circulation appearance, blood oxygen test probe combine together to form internally for blood to have a monitoring system that does not have, be equipped with venous blood test probe and arterial blood test probe on the blood gas monitoring devices, venous blood test probe and arterial blood test probe are used for the blood gas monitoring of the vein pipeline and the artery pipeline on the external circulation appearance respectively, have solved among the prior art and can't realize not having the external blood gas monitoring of wound, and have the technical problem that data is uncoordinated to the monitoring of internal external blood oxygen blood gas.
Description
Technical Field
The invention relates to the technical field of human blood oxygen detection, in particular to a non-invasive blood gas monitoring device and a non-invasive closed-loop monitoring system for in-vivo and in-vitro blood.
Background
Respiratory management during anesthesia and surgery is mainly to maintain stable and sufficient tissue oxygen supply of respiratory function to guarantee safety of patients during and after surgery, but clinical observation alone is not enough to make accurate estimation on respiratory state, and comprehensive judgment on respiratory state relies on blood oxygen gas analysis, so blood gas monitoring becomes an indispensable monitoring item for clinical anesthesia.
The blood gas monitoring is one of the important monitoring items in the extracorporeal circulation, the arterial blood gas measurement provides the ideal oxygen partial pressure, carbon dioxide partial pressure and PH of the infused blood, the venous blood gas measurement is the best basis for knowing whether the infusion is sufficient, and the monitoring instruments existing at home and abroad at present need to be connected into the extracorporeal circulation to monitor the blood gas, participate in the extracorporeal circulation and have certain influence on the patient. Moreover, the currently adopted external blood gas and internal blood oxygen are not synchronous in monitoring, and cannot form data cooperation, so that medical personnel cannot make timely and accurate judgment on patients.
Disclosure of Invention
The invention provides a non-invasive blood and gas monitoring device and a non-invasive closed-loop monitoring system for in-vivo and in-vitro blood and gas, aiming at solving the technical problems that non-invasive in-vitro blood and gas monitoring cannot be realized in the prior art and data are not coordinated in-vivo and in-vitro blood and gas monitoring.
The invention adopts the following technical scheme:
the utility model provides a do not have blood gas monitoring devices of wound, monitoring devices includes the casing and arranges in the test probe of casing one side, be equipped with on the casing with test probe electric connection's control module and display module, last temperature sensor, first light source and the first sensor and the second sensor of being equipped with of test probe, first light source respectively with first sensor and second sensor form different distance intervals, first sensor and second sensor respectively with control module electric connection, control module with display module electric connection, control module control the detection light of a plurality of kinds of wavelength is sent to first light source.
The shell is also internally provided with a data transmission module, the control module is connected with the mobile terminal through the data transmission module, and the data transmission module is used for transmitting the blood gas parameters obtained by the control module to the mobile terminal.
Further, controlling the wavelength of light emitted by the first light source comprises: 660nm, 735nm, 760nm, 810nm, 850nm, 905 nm.
The detection probe is also provided with a second light source and a third sensor, the first light source, the second sensor, the second light source and the third sensor are sequentially distributed in a straight line, the first light source is respectively unequal to the distance formed by the first sensor and the second sensor, and the second light source is respectively unequal to the distance formed by the third sensor and the second sensor.
Further, controlling the wavelength of light emitted by the first light source: 735nm, 810nm and 850nm for detecting the blood oxygen saturation and the hemoglobin concentration; controlling the wavelength of light emitted by the second light source: 660nm, 760nm and 905nm, and is used for detecting hematocrit.
The monitoring device further comprises an alarm module and a power module, wherein the power module is electrically connected with the control module, the detection probe, the display module and the alarm module respectively, and the alarm module is electrically connected with the control module.
On the other hand, the invention also provides an in vitro and in vivo blood non-invasive closed loop monitoring system, which comprises an extracorporeal circulation instrument, a blood oxygen detection probe and a blood gas monitoring device, wherein the blood gas monitoring device is the non-invasive blood gas monitoring device, the blood gas monitoring device is provided with a venous blood detection probe and an arterial blood detection probe, and the venous blood probe and the arterial blood probe are respectively used for synchronously monitoring the blood gas of a venous pipeline and an arterial pipeline on the extracorporeal circulation instrument.
The technical scheme of the invention has the following advantages:
A. the invention provides a portable, real-time, continuous and simple-operation noninvasive monitoring method for clinic, which is widely used in various occasions of extracorporeal circulation use and can obtain the values of the blood oxygen saturation, the hemoglobin concentration and the hematocrit which are easy for clinic application.
B. The invention adopts two light sources, each light source respectively emits light with three different wavelengths to detect the blood oxygen saturation, the hemoglobin concentration and the hematocrit, and the substance concentration in blood has difference due to the individual difference of detection, so that the substance absorption curves in blood have difference.
C. The invention provides a first detection unit and a second detection unit which are linearly distributed and composed of a first light source, a second light source and photoelectric sensors positioned on two sides of the first light source and the second light source, wherein the two detection units can be used for realizing mutual comparison between the two light sources so as to eliminate some environmental interference, for example, the second sensor positioned in the middle of the two detection units can simultaneously receive data of the two light sources, when the light intensity reflected by the two light sources is obviously different, if the difference is 2 times or more, the problem of one detection unit can be judged, and the abnormal alarm can be detected through an alarm module.
In addition, because the light emitting points of the same light source have position deviation, when the wavelength of the same light source is more, the light emitting point deviation of the light sources with different wavelengths is larger, and an output result has errors, each light source preferably emits light with three different wavelengths, and the two detection units are adopted to detect the blood oxygen saturation, the hemoglobin concentration and the hematocrit, so that the detection accuracy can be obviously improved.
D. The invention provides a monitoring system capable of monitoring blood oxygen in vivo and blood gas in vitro noninvasively, and based on a closed-loop monitoring scheme in vivo and in vitro, synchronous monitoring data can be provided for a user, blood gas parameters under the same standard can be obtained, and the monitoring system has the comparative reference property.
Drawings
In order to more clearly illustrate the embodiments of the present invention, the drawings which are needed to be used in the embodiments will be briefly described below, and it is apparent that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained from the drawings without inventive labor to those skilled in the art.
FIG. 1 is a schematic view of a flow tube monitoring structure of the monitoring device provided by the present invention;
FIG. 2 is a schematic view of a detection probe;
FIG. 3 is a schematic view of a monitoring device;
fig. 4 is a working principle diagram of the in vitro and in vivo blood non-invasive closed-loop monitoring system.
The labels in the figure are as follows:
1-shell
2-detection probe
21-temperature sensor, 22-first light source, 23-first sensor, 24-second sensor
25-second light source, 26-third sensor
3-the patient; 4-a control module; 5-a display module; 6-flow glass tube; 7-blood
a-a monitoring device; a 1-venous blood test probe; a 2-arterial blood detecting probe
b-an extracorporeal circulation apparatus; b 1-venous line; b 2-arterial line
c-blood oxygen detecting probe.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1 and 2, the present invention provides a non-invasive blood gas monitoring device, wherein a monitoring device a includes a housing 1 and a detection probe 2 disposed at one side of the housing 1, a control module 4 and a display module 5 electrically connected to the detection probe 2 are disposed in the housing 1, and a temperature sensor 21, a first light source 22, a first sensor 23 and a second sensor 24 are disposed on the detection probe 2, because the temperature has a certain influence on the dissolution rate, the influence of thermal expansion and cold contraction is considered, and the parameter is compensated and corrected by increasing the temperature. The first light source 22 forms different distance intervals with the first sensor 23 and the second sensor 24, the first sensor 23 and the second sensor 24 are electrically connected with the control module, and the control module 4 is electrically connected with the display module 5. The first sensor 23 and the second sensor 24 are preferably photo sensors, respectively, wherein the first light source 22 can emit light with a plurality of different wavelengths, including at least three of 660nm, 735nm, 760nm, 810nm, 850nm and 905nm, and the light sources can be controlled to emit light with more different wavelengths. The control module carries out data analysis on the received data to obtain related detection data, and the related detection data are displayed externally by the display module. The invention monitors the blood oxygen saturation, the hemoglobin concentration and the hematocrit in blood by near infrared spectroscopy based on the corrected Lambert-Beer law, provides a portable, real-time, continuous and simple-operation noninvasive monitoring method for clinic, is widely applied to various occasions of extracorporeal circulation use, and obtains the values of the blood oxygen saturation, the hemoglobin concentration and the hematocrit which are easy to apply clinically.
In order to realize remote data transmission, a data transmission module is further arranged in the shell 1, the control module is connected with the mobile terminal through the data transmission module, and the data transmission module is used for transmitting blood and gas parameters obtained by the control module to the mobile terminal and directly checking the data.
In the present invention, the second light source 25 and the third sensor 26 are further provided on the detection probe 2, and the first sensor 23, the first light source 22, the second sensor 24, the second light source 25, and the third sensor 26 are linearly arranged in this order, but are not limited to the arrangement shown in the drawing. The first light source 22 forms a first detection unit with the first sensor 23 and the second sensor 24, respectively, and the second light source 25 forms a second detection unit with the third sensor 26 and the second sensor 24, respectively, where the temperature sensor 21 at one end of the housing 1 serves as a third detection unit. Where the first light source 22 emits light at 3 different wavelengths: 735nm, 810nm and 850nm, and can detect parameters of blood oxygen saturation and hemoglobin concentration; the second light source 25 emits light at three different wavelengths: 660nm, 760nm and 905nm, and can detect parameters of hematocrit. The temperature sensor can detect 10-40 deg.C, and infrared temperature detecting probe with accuracy of + -0.5 deg.C and resolution of 0.02 deg.C is adopted.
As shown in fig. 1 and 3, the monitoring device a further includes an alarm module and a power module, the power module is electrically connected to the control module 4, the detection probe 2, the display module 5 and the alarm module, and the alarm module is electrically connected to the control module 4. The blood oxygen data signal of blood 7 in flow glass tube 6 is gathered to detecting probe 2, transmit control module 4 to carry out data processing and analysis at control module 4, when the numerical value that detects out surpassed the standard numerical value of setting for, alarm module sends the warning outward, for example the second sensor that is located two detecting element middles can receive the data of two light sources simultaneously, when the light intensity of two light source reflections had obvious difference, if the difference is 2 times and more, can judge that one of them detecting element goes wrong, can detect unusual the warning through alarm module. The alarm module may preferably be a buzzer, and the detected extracorporeal blood gas data may be displayed externally through the display module 5. Of course, the data may also be transmitted to the outside through a data transmission module, such as to a mobile terminal or the like.
As shown in fig. 4, the present invention further provides an in vitro and in vivo blood non-invasive closed loop monitoring system, which includes an extracorporeal circulation apparatus b, a blood oxygen detecting probe c and a blood gas monitoring apparatus a, wherein the blood gas monitoring apparatus a is the non-invasive blood gas monitoring apparatus shown in fig. 1 and 2, a venous blood detecting probe a1 and an arterial blood detecting probe a2 are arranged on the blood gas monitoring apparatus a, and the venous blood detecting probe a1 and the arterial blood detecting probe a2 are respectively used for blood gas monitoring of a venous pipeline b1 and an arterial pipeline b2 on the extracorporeal circulation apparatus b. Wherein the venous blood detection probe a1 monitors venous blood SvO2, Hb, Hct and Tv in vitro; the arterial blood detection probe a2 monitors for in vitro arterial blood SvO2, Hb, Hct, Tv; blood oxygen test probe c monitors patient 3's forehead and four limbs rSO2, StO2, forms the synchronous closed loop monitoring of internal blood oxygen, the continuous blood gas of extracorporeal circulation, can provide synchronous monitoring data for the user, obtains the blood gas parameter under same standard, but has contrast referential nature, but has solved among the prior art and can't realize in step not having the external blood gas monitoring of wound, and there is the technical problem that the data is uncoordinated to the monitoring of internal external blood oxygen blood gas.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are intended to be within the scope of the invention.
Claims (7)
1. A non-invasive blood gas monitoring device, characterized in that the monitoring device (a) comprises a shell (1) and a detection probe (2) arranged at one side of the shell (1), the shell (1) is provided with a control module (4) and a display module (5) which are electrically connected with the detection probe (2), the detection probe (2) is provided with a temperature sensor (21), a first light source (22), a first sensor (23) and a second sensor (24), the first light source (22) forms different distance intervals with the first sensor (23) and the second sensor (24), respectively, the first sensor (23) and the second sensor (24) are respectively electrically connected with the control module (4), the control module (4) is electrically connected with the display module (5), and the control module (4) controls the first light source (22) to emit detection light with a plurality of wavelengths.
2. The non-invasive blood gas monitoring device according to claim 1, wherein a data transmission module is further disposed in the housing (1), and the control module (4) is connected to a mobile terminal network through the data transmission module for transmitting the blood gas parameters obtained by the control module (4) to the mobile terminal.
3. The non-invasive blood gas monitoring device according to claim 1, wherein controlling the wavelength of the light emitted by the first light source (22) comprises: 660nm, 735nm, 760nm, 810nm, 850nm, 905 nm.
4. The non-invasive blood gas monitoring device according to claim 1, wherein the detection probe (2) is further provided with a second light source (25) and a third sensor (26), the first sensor (23), the first light source (22), the second sensor (24), the second light source (25) and the third sensor (26) are sequentially and linearly distributed, the first light source (22) and the first sensor (23) and the second sensor (24) form a first detection unit, and the second light source (25) and the third sensor (26) and the second sensor (24) form a second detection unit.
5. A non-invasive blood gas monitoring device according to claim 4, wherein the wavelength of the light emitted by the first light source (22) is controlled to: 735nm, 810nm and 850nm for detecting the blood oxygen saturation and the hemoglobin concentration; controlling the wavelength of light emitted by the second light source (25): 660nm, 760nm and 905nm, and is used for detecting hematocrit.
6. A non-invasive blood gas monitoring device according to claim 4, further comprising an alarm module and a power module, wherein the power module is electrically connected with the control module, the detection probe (2), the display module and the alarm module respectively, and the alarm module is electrically connected with the control module (3).
7. A non-invasive closed-loop monitoring system for in vitro and in vivo blood, which comprises an extracorporeal circulation instrument (b), a blood oxygen detection probe (c) and a blood gas monitoring device (a), and is characterized in that the blood gas monitoring device (a) is the non-invasive blood gas monitoring device according to any one of claims 1 to 6, a venous blood detection probe (a1) and an arterial blood detection probe (a2) are arranged on the blood gas monitoring device (a), and the venous blood probe (a1) and the arterial blood probe (a2) are respectively used for synchronously monitoring the blood gas of a venous pipeline (b1) and an arterial pipeline (b2) on the extracorporeal circulation instrument (b).
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| CN202110706911.6A CN113274012A (en) | 2021-06-24 | 2021-06-24 | Noninvasive blood gas monitoring device and noninvasive closed-loop monitoring system for in-vivo and in-vitro blood |
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| CN202110706911.6A CN113274012A (en) | 2021-06-24 | 2021-06-24 | Noninvasive blood gas monitoring device and noninvasive closed-loop monitoring system for in-vivo and in-vitro blood |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5259381A (en) * | 1986-08-18 | 1993-11-09 | Physio-Control Corporation | Apparatus for the automatic calibration of signals employed in oximetry |
| US5331958A (en) * | 1992-03-31 | 1994-07-26 | University Of Manitoba | Spectrophotometric blood analysis |
| CN1482448A (en) * | 2003-06-13 | 2004-03-17 | 周国明 | Non-invasive instrument for monitoring blood oxygen saturation of extracorporeal circulation |
| CN103622703A (en) * | 2013-12-05 | 2014-03-12 | 深圳市奥博莱特科技有限公司 | Human tissue blood oxygen saturation degree absolute amount detection device and method |
| CN108451513A (en) * | 2017-02-22 | 2018-08-28 | 清华大学深圳研究生院 | A kind of paster style physiological multi-parameter monitoring equipment |
| CN111466923A (en) * | 2020-05-14 | 2020-07-31 | 中科搏锐（北京）科技有限公司 | Multi-channel tissue blood oxygen synchronous non-invasive monitoring device and method thereof |
-
2021
- 2021-06-24 CN CN202110706911.6A patent/CN113274012A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5259381A (en) * | 1986-08-18 | 1993-11-09 | Physio-Control Corporation | Apparatus for the automatic calibration of signals employed in oximetry |
| US5331958A (en) * | 1992-03-31 | 1994-07-26 | University Of Manitoba | Spectrophotometric blood analysis |
| CN1482448A (en) * | 2003-06-13 | 2004-03-17 | 周国明 | Non-invasive instrument for monitoring blood oxygen saturation of extracorporeal circulation |
| CN103622703A (en) * | 2013-12-05 | 2014-03-12 | 深圳市奥博莱特科技有限公司 | Human tissue blood oxygen saturation degree absolute amount detection device and method |
| CN108451513A (en) * | 2017-02-22 | 2018-08-28 | 清华大学深圳研究生院 | A kind of paster style physiological multi-parameter monitoring equipment |
| CN111466923A (en) * | 2020-05-14 | 2020-07-31 | 中科搏锐（北京）科技有限公司 | Multi-channel tissue blood oxygen synchronous non-invasive monitoring device and method thereof |
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