CN113209217A - Traditional Chinese medicine composition for resisting physical fatigue and preparation method thereof - Google Patents
Traditional Chinese medicine composition for resisting physical fatigue and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an antibody fatigue-resisting traditional Chinese medicine composition and a preparation method thereof, wherein the composition is prepared from the following raw materials in parts by weight: 3 parts of ginseng, 5 parts of Chinese date and 10 parts of lily. The invention takes ginseng as a basic source substance, and under the guidance of the theory of traditional Chinese medicine, aiming at the warm and dry nature of ginseng, the ginseng is scientifically compatible with the cold and cool raw material lily which is homologous in medicine and food according to the traditional processing principle of 'processing in reverse direction', and the dryness of ginseng is reduced by adopting the preparation method of the traditional Chinese medicine. And the Chinese date is matched to achieve the effects of benefiting qi, nourishing blood and relieving physical fatigue. The product of the invention has high safety and small toxic and side effects, and the preparation method has the advantages of simple operation, high efficiency, economy, environmental protection, no toxicity and wide application prospect.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition for resisting fatigue and a preparation method thereof.
Background
With the fast pace of life and the great pressure, fatigue has become a common symptom in people's life. If the fatigue symptoms cannot be relieved for a long time, the working efficiency and the life quality of people can be influenced, and even physical or psychological diseases such as depression and the like can be caused. Fatigue has become a concern of people in the world, and common fatigue mainly comprises physical fatigue, mental fatigue, psychological fatigue and visual fatigue. The physical fatigue refers to a physiological phenomenon of reduced function when the body continuously moves to a certain stage, mainly manifested as fatigue and weakness, and is the most fatigue phenomenon at present and a hot spot of fatigue research. The continuous physical fatigue is easy to induce sports injury, thereby bringing hidden troubles to the body of a long-term exerciser.
Ginseng contains abundant chemical components, including ginsenoside, phytosterol, phenols, and polysaccharide. Has the biological activities of fatigue resistance, immunoregulation, oxidation resistance, infection resistance and the like. Wherein the ginsenoside and total polysaccharides of Ginseng radix are closely related to antifatigue. Protopanaxadiol in ginsenoside can reduce the damage of oxide generated after exercise to body tissues by reducing oxidative stress index; can also reduce the accumulation of metabolic substances such as lactic acid, urea nitrogen and the like in vivo to play a role in resisting fatigue by increasing the activity of lactate dehydrogenase. The panaxan can be used as an immunostimulant, and can stimulate various immunocompetent cells of organism, thereby improving immunity and resisting fatigue. It can also be used for preventing damage of erythrocyte membrane caused by lipid oxidation and reducing consumption of glycogen and glutamic acid by consuming triglyceride to delay body fatigue by changing activities of malondialdehyde and glutathione peroxidase.
The Chinese date contains abundant polysaccharides, is divided into neutral polysaccharide and acidic polysaccharide, is an important anti-fatigue active substance, has the capacity of increasing glycogen storage and reducing metabolite accumulation, can also obviously improve spleen indexes, improve the conversion capacity of T and B lymphocytes, improve the immune function, reduce the content of serum malondialdehyde, prevent the peroxidation damage of lipid and achieve the effect of relieving fatigue.
The lily polysaccharide which is the main component of lily can accelerate the metabolism of serum lactic acid and urea nitrogen by increasing the content of hemoglobin in vivo, play the anti-fatigue effect, obviously enhance the phagocytic function of macrophage in a dose-dependent manner, and enhance the immunity of the organism so as to enhance the endurance.
The mild warm nature of ginseng often causes the adverse phenomena of bleeding and blood pressure increase of the user due to its dryness, which affects its anti-fatigue efficacy. The lily is cold in nature and is combined with the ginseng, so that the dryness of the ginseng can be reduced or eliminated, the anti-fatigue activity of the ginseng can be improved, and the immunity of the organism can be improved. The Chinese date has the efficacy of tonifying qi and enriching blood, the ginseng has the efficacy of greatly reinforcing primordial qi, and the combination of the Chinese date and the ginseng can achieve the peculiar efficacy of tonifying qi and nourishing blood. In addition, the saponin and the polysaccharide in the ginseng, the polysaccharide in the Chinese date and the polysaccharide in the lily have strong anti-fatigue effects, and the saponin, the polysaccharide in the ginseng, the polysaccharide in the Chinese date and the polysaccharide in the lily can play a synergistic effect.
The method for evaluating the anti-fatigue effect mainly combines a movement endurance test and biochemical index detection. Forced swimming tests are considered to be the most objective and easy-to-operate model for observing the anti-fatigue effect of drugs, and are also the most widely used model. The commonly used biochemical indexes mainly include liver glycogen, muscle glycogen, serum urea nitrogen, blood lactic acid and the like. If more than 1 endurance exercise test and more than 2 biochemical indexes are positive, or 3 dosage endurance exercise tests are positive, and 1 biochemical index is positive, the tested object can be judged to have the anti-fatigue activity.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition which has the function of resisting fatigue, is convenient to take and low in cost and can be frequently taken at ordinary times and a preparation method thereof.
The purpose of the invention can be realized by the following technical scheme:
the traditional Chinese medicine composition for resisting fatigue is prepared from the following raw materials in parts by weight: 3 parts of ginseng, 5 parts of Chinese date and 10 parts of lily.
The traditional Chinese medicine composition is granules.
The preparation process comprises the following steps:
taking a ginseng medicinal material, adding 15 times of 65% ethanol, extracting for 2 times, each time for 1 hour, filtering, combining filtrates, recovering ethanol from the filtrates, and concentrating to obtain thick paste with the relative density of 1.10-1.20 (75 ℃) for later use.
Extracting the Chinese dates, the lily and the dregs of the decoction after alcohol extraction with 15 times of water at 90 ℃ for 2 times, each time for 2 hours, filtering, combining the filtrates, and concentrating the filtrate under reduced pressure to obtain thick paste with the relative density of 1.10-1.20 (75 ℃) for later use.
Mixing the two soft extracts, adding adjuvants, drying, pulverizing, and sieving with 80 mesh sieve to obtain mixed powder; and (3) preparing the prepared mixed powder into a material by using ethanol, granulating, drying and grading to obtain the target product.
As a further preferable scheme of the preparation method of the granules, the preparation method further comprises the step of preparing the mixed powder and pharmaceutically acceptable auxiliary materials into medicines or health-care foods.
The auxiliary materials are soluble starch and dextrin.
The taking method comprises the following steps: the medicine is taken 1 bag each time, twice a day, and 30 days is a course of treatment.
The invention has the beneficial effects that: the health-care granules prepared by the invention are prepared from pure traditional Chinese medicines, so that the toxicity and side effects of the medicines are reduced or eliminated.
Compared with the prior art, the invention has the beneficial effects that: the lily and the ginseng are combined, so that the dryness of the ginseng can be reduced and eliminated, and the functions of resisting fatigue, improving the immunity of the organism and the like of the ginseng can be enhanced. The Chinese date has the effects of strengthening spleen and tonifying stomach, and tonifying qi and enriching blood, can achieve the peculiar effects of tonifying qi and nourishing blood by being matched with the ginseng, is used for daily conditioning of patients with deficiency of spleen-stomach qi and deficiency of qi and blood, and can greatly improve the immunity and the anti-fatigue effect of drinkers.
The preparation method of the granules is simple to operate, environment-friendly, economical, efficient, nontoxic and wide in application prospect.
Detailed Description
The technical solution of the present invention will be described in more detail with reference to the following embodiments.
A traditional Chinese medicine composition with antibody fatigue is prepared according to the following method:
weighing 3 parts of ginseng respectively in the step (1), adding 65% ethanol which is 15 times of the total amount of the medicinal materials, heating and refluxing for 2 times at 90 ℃, extracting for 1 hour each time, filtering, combining the filtrates, recovering ethanol from the filtrate, and concentrating to obtain thick paste with the relative density of 1.10-1.20 (75 ℃) for later use.
And (2) weighing 3 parts of ginseng, 5 parts of Chinese date and 10 parts of lily respectively, adding water which is 15 times the longitudinal volume of the medicinal materials, leaching for 2 times at 90 ℃ for 2 hours each time, filtering, combining filtrates, and concentrating the filtrate under reduced pressure to obtain thick paste with the relative density of 1.10-1.20 (75 ℃) for later use.
Selecting soluble starch: dextrin (7: 3) is used as an auxiliary material, the prepared two thick pastes are combined, 0.8 time of the auxiliary material is added and mixed evenly, and the mixture is placed in a forced air drying oven at the temperature of 80 ℃ for drying, crushing and sieving by a 80-mesh sieve to obtain mixed powder.
Adding 0.26 times of 93% ethanol, sieving with 14 mesh sieve, granulating, drying at 60 deg.C for 40min, and sieving with 14 mesh sieve.
Research on effect of traditional Chinese medicine composition in relieving physical fatigue
1 materials of the experiment
1.1 animals
The clean-grade male Kunming mouse has the weight of 16-20g, is provided by Yisi experimental animal technology, Limited liability company in Changchun city, and has an animal certification number: 202000034837,. Producing license numbers: SCXK (Ji) 2015-. Environmental facility qualification number of SPF experimental animals: SCXK (Ji) 2016-. All animals were given sterilized rat feed and sterilized water for free access.
1.2 instruments
An AL20 type electronic analytical balance, an FL600 type microplate reader, an SK-1 type rapid mixer, an UV-5500 ultraviolet spectrophotometer, a swimming box (53cm multiplied by 40cm multiplied by 35cm), a lead rope, a timer, a clean bench, a sterile surgical instrument, an injector (1mL) and a constant temperature water bath kettle.
1.3 reagents
Heparin sodium, urea nitrogen kit, liver/muscle glycogen kit
1.4 samples
Chinese medicinal composition
2 course of experiment
2.1 grouping and dosage
A blank control group, a low dose group, a medium dose group, and a high dose group were set, respectively, and 10 animals per group.
The administration dosage of the Chinese medicinal composition granule in low, medium and high groups is 0.83g/kg/d, 1.65g/kg/d and 2.25g/kg/d respectively, and the administration is performed by gastric lavage. The blank dose group was given an equal volume of saline for 30 consecutive days.
2.2 body weight determination
The body weight of each group of mice before and after administration was recorded daily for 30 consecutive days, and the percentage of body weight increase was calculated.
2.3 physical fatigue relieving experimental method
According to a test method of health food inspection and evaluation technical specification (2003 edition), the effect of the health product on prolonging the weight swimming time of the mouse is measured through a weight swimming test; determining the liver glycogen content (anthrone method) to judge the effect of the sample on promoting the liver glycogen storage of the mouse; and (5) measuring serum urea, and judging the effect of the sample on reducing the accumulation of the serum urea of the fatigue mice.
2.3.1 weight bearing swimming test
30min after the last administration of the test sample, a mouse whose tail root was loaded with a 5% weight lead rope was placed in a swimming box for swimming (water depth: 30cm, water temperature: 25. + -. 0.5 ℃). The time from the start of free swimming to exhaustion of the mice, i.e. the time of weight swimming of the mice, was recorded. If the time of the load swimming of the test sample group is obviously longer than that of the control group, and the difference is significant, the experimental result can be judged to be positive.
2.3.2 serum Urea Nitrogen determination
After the mice swim with a load, blood was taken immediately, and the supernatant was collected by centrifugation (1500r/min, 10 min). And (3) determining the urea nitrogen content in the serum of the mouse after exercise by adopting a urea nitrogen kit. If the serum urea of the test sample group is lower than that of the control group and the difference is significant, the experimental result can be judged to be positive.
2.3.3 measurement of liver glycogen and muscle glycogen
After the eyeball of the mouse is picked up and blood is taken, the cervical vertebra is taken off and the mouse is killed, and the fresh muscle and liver of the hind limb are taken immediately. And (3) determining the contents of liver glycogen and muscle glycogen of the mice after exercise by using the glycogen kit, and if the glycogen content of the test sample group is higher than that of the control group and the difference is significant, judging that the experimental result is positive.
3 physical fatigue relieving experimental result
3.1 Effect of samples on mouse body weight
Table 1 effect on mouse body weight (X ± s, n ═ 10)
In table 1, after 30 days of continuous administration, the weight of mice in each administration group is increased, but there is no significant difference between the groups, and the weight difference of the administration group is not significant (P is more than 0.05) compared with the blank group, which indicates that the ginseng formula granules have no influence on the weight of the mice.
3.2 Effect of samples on mouse swimming time under weight, liver/muscle glycogen content, Urea Nitrogen level
Table 2 effect on mouse weight swimming time, liver/muscle glycogen content, urea nitrogen level (X ± s, n ═ 10)
Note: p < 0.05, P < 0.01, P < 0.001, compared to the blank control group.
As shown in Table 2, 3 doses in the administered group were able to prolong the weight swimming time of mice compared with the blank control group, and had statistical significance (. about.P < 0.05). The result shows that the traditional Chinese medicine composition granules have better fatigue effect. In the low, medium and high 3 dose groups, the mice in the medium dose group had the longest swimming time, which was significantly higher than that in the low dose group (P < 0.05), but the difference was not significant (P > 0.05) compared with the high dose. Therefore, the dosage of the traditional Chinese medicine composition granules is the optimal dosage for resisting antibody fatigue.
As shown in Table 2, 3 doses of the administered group significantly reduced the urea nitrogen content in the serum of the mice compared to the blank control group. The blank control group and the low dose group have no significant difference (P > 0.05), and the medium and high doses have very significant difference (P < 0.001). However, no significant difference (P > 0.05) exists between the medium and high doses, so the dose group in the granules is selected as the optimal dose, which is consistent with the endurance test result.
As can be seen from table 2, the mouse myoglycogen and liver glycogen contents (. beta.. beta.P < 0.001) were significantly increased in both the high dose group and the blank control group, but there was no significant difference between the low dose group and the blank control group (P > 0.05). There was no significant difference between the medium and high doses (P > 0.05). The middle dose group was selected as the optimal dose to be administered, which was consistent with the results of the previous experiments.
4 results of the experiment
In the physical fatigue relieving experiment, the traditional Chinese medicine composition granules have no influence on the weight of a mouse. Compared with a blank control group, the low, medium and high dosage groups of the granules can obviously prolong the weight swimming time of mice, which shows that the product has better physical fatigue resistance effect. The product can reduce the urea nitrogen content in the serum of the mouse by using low, medium and high doses of 3 doses, wherein the urea nitrogen content is reduced obviously by using the medium and high dose groups, and the muscle glycogen and liver glycogen content in the tissue of the mouse can be increased obviously. Therefore, the traditional Chinese medicine composition granules can play a role in resisting fatigue from multiple aspects, and the medium dosage group is the optimal dosage to take.
Claims (10)
1. A traditional Chinese medicine composition for resisting fatigue is characterized in that: comprises Ginseng radix, fructus Jujubae and Bulbus Lilii.
2. The traditional Chinese medicine composition with antibody fatigue resistance of claim 1, which is characterized in that: aiming at the warm and dry nature of the ginseng, the traditional processing principle of 'processing in reverse' is adopted, the traditional Chinese medicine is scientifically combined with the cold and cool raw material lily which is homologous in medicine and food, and the preparation method of the traditional Chinese medicine is adopted, so that the dryness of the ginseng is reduced.
3. The traditional Chinese medicine composition with antibody fatigue resistance of claim 1, which is characterized in that: the Chinese date has the effects of tonifying spleen and stomach, and tonifying qi and enriching blood, and can achieve the peculiar effects of tonifying qi and nourishing blood by being matched with the ginseng.
4. The traditional Chinese medicine composition with antibody fatigue resistance of claim 1, which is characterized in that: ginseng, jujube and lily all have strong anti-fatigue effects, and can be used together with Ginseng to exert curative effect.
5. The traditional Chinese medicine composition with antibody fatigue resistance of claim 1, which is characterized in that: the weight ratio of the ginseng, the Chinese date and the lily is 3: 5: 10.
6. the preparation method of the traditional Chinese medicine composition for resisting the fatigue is characterized by comprising the following steps of:
respectively cleaning ginseng, Chinese date and lily, and using the cleaned ginseng, Chinese date and lily as a preparation after the inspection is qualified; step (2), taking a ginseng medicinal material, adding 15 times of 65% ethanol, extracting for 2 times, each time for 1 hour, filtering, combining filtrates, recovering ethanol from the filtrates, and concentrating to obtain a thick paste with the relative density of 1.10-1.20 (75 ℃) for later use; step (3), extracting the Chinese dates, the lily and the dregs of the decoction after alcohol extraction for 2 times by adding 15 times of water at 90 ℃, filtering for 2 hours each time, combining the filtrates, and concentrating the filtrate under reduced pressure to form thick paste with the relative density of 1.10-1.20 (75 ℃) for later use; step (4), combining the two thick pastes prepared in the steps (2) and (3), adding auxiliary materials, drying, crushing, and sieving by a 80-mesh sieve to obtain mixed powder; and (5) preparing the mixed powder into a material by using ethanol, granulating, drying, grading, checking and packaging to obtain the target product.
7. The preparation method of the antibody-induced fatigue traditional Chinese medicine composition as claimed in claim 6, wherein in the step (2), 15 times of 65% ethanol is added to the ginseng, the ginseng is extracted for 2 times, 1 hour is carried out each time, the filtrate is filtered, the filtrate is combined, the ethanol is recovered, and the filtrate is concentrated to a thick paste with the relative density of 1.10-1.20 (75 ℃).
8. The preparation method of the traditional Chinese medicine composition for resisting antibody fatigue as claimed in claim 6, wherein in the step (3), the Chinese dates, the lily and the dregs after alcohol extraction are extracted for 2 times by adding 15 times of water at 90 ℃, the decoction is filtered, the filtrates are combined, and the filtrate is concentrated under reduced pressure to thick paste with the relative density of 1.10-1.20 (75 ℃) for later use.
9. The preparation method of the antibody-induced fatigue traditional Chinese medicine composition according to claim 6, wherein in the step (4), the two thick pastes prepared in the steps (2) and (3) are combined, added with auxiliary materials, dried, crushed and sieved by a 80-mesh sieve to obtain mixed powder; and (3) preparing the prepared mixed powder into a material by using ethanol, granulating, drying and grading to obtain the target product.
10. The method for preparing the traditional Chinese medicine composition for resisting antibody fatigue according to claim 9, which is characterized by further comprising the step of preparing the thick paste prepared in the steps (2) and (3) and pharmaceutically acceptable auxiliary materials into medicines or health-care food.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115944091A (en) * | 2023-02-21 | 2023-04-11 | 江苏艾兰得营养品有限公司 | Anti-fatigue tablet and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115944091A (en) * | 2023-02-21 | 2023-04-11 | 江苏艾兰得营养品有限公司 | Anti-fatigue tablet and preparation method and application thereof |
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Application publication date: 20210806 |