CN113198102B - Microneedle patch for regulating and controlling mechanical action - Google Patents

Microneedle patch for regulating and controlling mechanical action Download PDF

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Publication number
CN113198102B
CN113198102B CN202110536394.2A CN202110536394A CN113198102B CN 113198102 B CN113198102 B CN 113198102B CN 202110536394 A CN202110536394 A CN 202110536394A CN 113198102 B CN113198102 B CN 113198102B
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China
Prior art keywords
layer
microneedle
mechanical
base layer
base
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CN113198102A (en
Inventor
顾宇灵
张显玉
王涛
武欣越
庞达
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Shanghai Tianyin Biotechnology Co ltd
Harbin Medical University
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Shanghai Tianyin Biotechnology Co ltd
Harbin Medical University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Abstract

The invention relates to a method for regulating and controlling the mechanical action of a microneedle patch and the microneedle patch, which are characterized in that: the method for changing the original mechanical effect of the microneedle patch by adding the mechanical regulation layer on the microneedle base layer of the microneedle patch comprises the base layer and the reinforcing rib layer or the driving layer, wherein the mechanical regulation layer is composed of the base layer and the reinforcing rib layer or the driving layer, and the controllable regulation of the mechanical effect of the microneedle base layer is realized through the action change of the reinforcing rib layer structure or the driving layer.

Description

Micro-needle patch for regulating and controlling mechanical effect
Technical Field
The invention relates to a microneedle patch for regulating and controlling mechanical action.
Background
Compared with a conventional drug carrier, the microneedle patch has a fine-designed microstructure and superior drug loading capacity, can realize loading and release of active drugs, has received wide attention as a multifunctional patch, and has achieved remarkable achievement in the fields of wound healing, disease treatment, biosensing, skin immunity and the like.
Disclosure of Invention
The invention provides a microneedle patch for regulating and controlling mechanical action, which can promote the skin at the joint to grow and change in an expected manner by changing the mechanics and the form of the microneedle patch.
In order to achieve the purpose, the invention adopts the technical scheme that:
a method for regulating and controlling the mechanical action of a microneedle patch is characterized by comprising the following steps: a method for changing the original mechanical effect of the microneedle patch by adding a mechanical regulation layer on the microneedle base layer of the microneedle patch;
the mechanical regulation and control layer consists of a base layer and a reinforcing rib layer or a driving layer;
the controllable adjustment of the mechanical effect of the microneedle base layer is realized through the action change of the reinforcing rib layer structure or the driving layer;
the driving layer changes are driven by the driver to act on the mechanical regulation and control layer, and the action can be contraction towards the center, can also be contraction along one direction, and can also be contraction according to different positions and directions;
the action may be continuous or periodic;
the periodicity is that the periodicity changes of the changing action comprise cycle time and contraction amplitude, the driving layer is connected with the driver, the driver drives the driving layer to contract towards the center direction or contract towards a single direction or contract towards different directions, the driving layer is made of an electric contraction material or a pressure contraction structure and is driven by the external driver;
the driving layer is integrally arranged with the shrinkage material or the shrinkage structure or is arranged in a specific shape or is locally arranged in a strip shape in a certain direction, or is arranged in a strip shape in a plurality of directions, so that the driving layer moves in a specific direction, the micro-needle paste is driven to move and change, and different mechanical effects are achieved.
The method for regulating and controlling the mechanical action of the microneedle patch comprises the following steps: the reinforcing rib layer structure changes the difference of mechanical properties in different directions and positions on the plane of the mechanical regulation layer by using the arrangement of reinforcing ribs;
the reinforcing ribs are arranged in a straight line or in a curve according to different required mechanical properties;
the arranged reinforcing ribs are independent from each other and are not contacted with each other or are staggered with each other;
the reinforcing ribs are arranged in parallel or staggered according to an angle;
the reinforcing ribs are locally arranged in partial areas, and the partial areas are not arranged or are arranged in the whole areas;
the arrangement density of different positions of the arranged reinforcing ribs is uniform or not uniform;
the width, the height and the length of the arranged reinforcing ribs are mutually the same or mutually different;
under the condition that the mechanical property requirements in different directions are consistent, the reinforcing ribs are uniformly laid on the base layer of the whole mechanical regulation and control layer, and the height of the reinforcing ribs is as low as possible when the mechanical target is met.
A microneedle patch for regulating and controlling mechanical action is characterized in that: the microneedle patch comprises a microneedle base layer and a mechanical regulation layer;
the microneedle base layer comprises microneedles and a microneedle attachment layer, and the microneedle attachment layer is a base surface of the microneedles;
the mechanical regulation and control layer and the microneedle attachment layer are fixed relative to the other side of the microneedle;
the mechanical regulation and control layer consists of a base layer and a reinforcing rib layer or a driving layer;
the controllable adjustment of the mechanical effect of the microneedle base layer is realized through the action change of the reinforcing rib layer structure or the driving layer;
the driving layer is connected with a driver, the driver drives the driving layer to shrink towards the center direction or shrink in a single direction or shrink in different directions, the driving layer is made of an electric shrinkage material or a pressure shrinkage structure and is driven by the external driver;
the driving layer is provided with a plurality of contracting materials or contracting structures, wherein the contracting materials or the contracting structures are integrally arranged or arranged in a specific shape or locally arranged in a strip shape in a certain direction, or arranged in a strip shape in a plurality of directions, so that the driving layer moves in a specific direction, the microneedle patch is driven to move, and different mechanical effects are achieved.
The invention has the beneficial effects that: the mechanical regulation and control layer can promote the skin at the joint to grow and change according to an expected mode by changing the mechanics and the form of the microneedle patch.
The microneedle patch, wherein: the base layer of the mechanical regulation and control layer is a base surface of the mechanical regulation and control layer, one surface of the base layer is attached to the base surface of the microneedle patch, and the other surface of the base layer is used for fixing the reinforcing rib;
for simple production, the base surface of the microneedle and the base surface of the mechanical control layer may be combined into one;
or the microneedle patches are made of the same material and comprise the microneedles, the base layer and the reinforcing ribs, and the materials can be degradable gel medical usable materials.
The microneedle patch, wherein: the reinforcing ribs are straight lines or curved lines;
the cross section of the reinforcing rib is semicircular, rectangular or square, or the length close to the base surface is longer than the length far away from the base surface, and the width and the thickness of the cross section of the reinforcing rib are far smaller than the length of the reinforcing rib;
the reinforcing ribs are arranged in parallel according to a straight line or a curve, and the ductility in the arrangement direction is obviously weaker than that in the vertical direction;
the reinforcing ribs are arranged in partial areas, and the partial areas are not arranged, so that the effects of less deformation of the arranged areas and good elasticity of the non-arranged areas are achieved, and the reinforcing ribs are arranged according to different angles, so that mechanical change according to specific angles can be achieved;
the reinforcing ribs can realize different position mechanical effects on arrangement density, and the density place has weaker elasticity than the thin place.
The invention has the beneficial effects that: the mechanical regulation and control layer can promote the skin at the joint to grow and change according to an expected mode by changing the mechanics and the form of the microneedle patch.
Drawings
Fig. 1 is a structural view of an embodiment of a microneedle patch.
Fig. 2 is a structural view of another embodiment of the microneedle patch.
Fig. 3 is a structural view of the longitudinal arrangement of a bead layer of a microneedle patch.
Fig. 4 is a structural view of an oblique arrangement of a bead layer of a microneedle patch.
Fig. 5 is a structural view of a cross arrangement of a bead layer of a microneedle patch.
Fig. 6 is a structural diagram of a vertical cross arrangement of a stiffener layer of a microneedle patch.
Fig. 7 is a structural view of a uniform arrangement of a bead layer of a microneedle patch.
Fig. 8 is a structural view of uneven arrangement of a bead layer of a microneedle patch.
Fig. 9 is a structural view showing the oblique contraction of the driving layer of the microneedle patch.
Fig. 10 is a structural view of the microneedle patch contracted at the center of the driving layer.
Fig. 11 is a structural view showing the contraction of the driving layer of the microneedle patch.
Fig. 12 is a structural view of the microneedle patch with the driving layer shrunk at the irregular center.
Description of reference numerals: 1-microneedle base layer; 2-microneedles; 3-reinforcing rib layer; 4-a mechanical control layer; 5-a drive layer; 6-reinforcing ribs.
Detailed description of the preferred embodiments
As shown in fig. 1 to 12, a method for regulating and controlling a mechanical action of a microneedle patch is characterized in that: the method for changing the original mechanical effect of the microneedle patch by adding the mechanical regulation and control layer 4 on the microneedle base layer 1 of the microneedle patch is characterized in that the mechanical regulation and control layer 4 consists of the base layer and the reinforcing rib layer 3 or the driving layer 5, and the controllable regulation of the mechanical effect of the microneedle base layer 1 is realized through the action change of the reinforcing rib layer 3 or the driving layer 5.
The 3 structures of strengthening rib layer use arranging of strengthening rib 6 to change mechanical properties's difference on the mechanical regulation and control layer 4 plane on equidirectional and the position, according to required mechanical properties difference, strengthening rib 6 arranges with sharp or with the curve that mutually independent contactless or crisscross each other between the strengthening rib 6, strengthening rib 6 arranges that parallel to each other or according to the angle is crisscross, strengthening rib 6 arranges in the subregion part, and subregion do not arranges or whole regional arrangement, arranges the even and inhomogeneous of the density of arranging of strengthening rib 6 different positions, arrange width, height, the length of strengthening rib 6 are the same each other, or are different each other, to the unanimous condition of mechanical properties demand in the different directions under, strengthening rib 6 evenly lays on the basic unit on whole mechanical regulation and control layer, to strengthening rib 6's height, the lower is better when satisfying mechanical targets.
The change of the driving layer 5 is to drive the mechanical regulation layer 4 to act through a driver, the action can be contraction towards the center, can also be contraction along one direction, and can also be contraction according to different positions and directions, the action can be continuous, and can also be periodic, the periodicity is the periodic change of the change action and comprises period time and contraction amplitude, the driving layer 5 is connected with the driver, the driver drives the driving layer 5 to contract towards the center direction or in a single direction, or in different directions, the driving layer 5 is made of an electric contraction material or a pressure contraction structure and is driven by an external driver, the contraction material or the contraction structure on the driving layer 5 is integrally arranged or arranged in a specific shape or locally arranged in a strip shape according to a certain direction, or arranged in a strip shape in multiple directions, so that the driving layer 5 moves according to a specific direction, the driving of the sticking action change is realized, and different mechanical action effects of the microneedle are achieved.
A microneedle patch for regulating and controlling mechanical action is characterized in that: the micro-needle patch comprises a micro-needle base layer 1 and a mechanical regulation and control layer 4, wherein the micro-needle base layer 1 comprises a micro-needle 2 and a micro-needle attachment layer, the micro-needle attachment layer is a base surface of the micro-needle 2, the mechanical regulation and control layer 4 is fixed on the other surface of the micro-needle 2 relative to the micro-needle attachment layer, the mechanical regulation and control layer 4 comprises the base layer and a reinforcing rib layer 3 or a driving layer 5, and the controllable regulation of the mechanical effect of the micro-needle base layer 1 is realized through the action change of the reinforcing rib layer 3 or the driving layer 5.
The basic unit of mechanics regulation and control layer 4 does the basic unit of mechanics regulation and control layer 4 simultaneously in the fine needle pastes the fine needle the basic unit laminating, one side is used for the fixing of strengthening rib 6 in order simple production, can be with the fine needle 2 the basic unit with mechanics regulation and control layer 4 the basic unit unites two into one, perhaps the fine needle pastes all uses the same material to include the fine needle 2 the basic unit reaches strengthening rib 6, affiliated material can be the available material of degradable gel class medical treatment.
The reinforcing ribs 6 are straight lines or curves, the cross sections of the reinforcing ribs are semicircular, rectangular and square, or the length of the reinforcing ribs close to the base surface is larger than the length of the reinforcing ribs far away from the base surface, the width of the cross section of each reinforcing rib 6 is far smaller than the length of each reinforcing rib, the reinforcing ribs 6 are arranged in parallel according to the straight lines or the curves, the ductility of the reinforcing ribs in the arrangement direction is obviously weaker than that of the reinforcing ribs in the vertical direction, the reinforcing ribs 6 are arranged in partial areas, the deformation of the arrangement areas is reduced without arranging the effect that the elasticity of the areas is good, the reinforcing ribs 6 are arranged according to different angles, the mechanical change according to specific angles can be realized, the mechanical effects of different positions of the reinforcing ribs 6 in the arrangement density can be different, and the local elasticity of the reinforcing ribs is weaker than that of the thin areas.
The utility model discloses a micro-needle patch, including drive layer 5, driver, drive layer 5, the driver drive 5 is to central direction shrink or unidirectional contraction, perhaps equidirectional shrink, drive layer 5 is by electric shrinkage material or pressure contraction structure preparation, by external the driver drive, shrink material or shrink structure are whole to be arranged or arrange with specific shape according to certain direction local with the strip on the drive layer 5, thereby perhaps a plurality of directions arrange with the strip and realize drive layer 5 moves according to specific direction, realizes driving the micro-needle pastes the action and changes, reaches different mechanical action effects.
The examples are as follows:
specifically, as shown in fig. 1, a mechanical regulation layer 4 is added on the microneedle base layer 1, the mechanical regulation layer 4 is composed of a base layer and a reinforcing rib layer 3, and the controllable regulation of the mechanical effect of the microneedle base layer 1 is realized through the structure of the reinforcing rib layer 3.
Specifically, as shown in fig. 2, the mechanical regulation layer 4 is added on the microneedle base layer 1, the mechanical regulation layer 4 is composed of a base layer and a driving layer 5, and the controllable adjustment of the mechanical effect of the microneedle base layer 1 is realized through the action change of the driving layer 5.
In particular, the longitudinal arrangement of the reinforcing bars 6 on the reinforcing bar layer 3 as shown in fig. 3 enables the ductility in the arrangement direction to be significantly weaker than that in the perpendicular direction.
Specifically, as shown in fig. 4 to 6, the reinforcing ribs 6 are obliquely, crosswise and perpendicularly and crosswise arranged on the reinforcing rib layer 3, so that mechanical change according to a specific angle can be realized.
Specifically, as shown in fig. 7 to 8, if the bead layers 3 are uniformly or non-uniformly arranged in some regions, the effect that the deformation of the arranged regions is small and the elasticity of the non-arranged regions is good is achieved.
Specifically, as shown in fig. 9, the driving layer 5 can drive the microneedle patch to obliquely shrink through the oblique contraction of the driver, so as to achieve different mechanical effects.
Specifically, as shown in fig. 10, the driving layer 5 can be retracted toward the center by the driver, so as to drive the microneedle to move toward the center, thereby achieving different mechanical effects.
Specifically, as shown in fig. 11, the driving layer 5 can be contracted in opposite directions by the driver, so as to drive the microneedle patch to contract in opposite directions, thereby achieving different mechanical effects.
Specifically, as shown in fig. 12, the driving layer 5 can be retracted to the irregular center by the driver, so as to drive the microneedle to move toward the irregular center, thereby achieving different mechanical effects.
The medicines which can be added into the degradable gel comprise compound betamethasone injection (trade name: diprospan), tranexamic acid injection (trade name: chlorpheniramine), timolol injection, botulinum toxin injection A (trade name: balance force, adequacy), hyaluronic acid, collagen, vitamin C injection, vitamin B group injection, 5 fluorouracil injection and lidocaine injection, and the medicines can maximize the treatment effects of scar removal and skin care.
The invention has the advantages that:
the mechanical regulation and control layer can promote the skin at the joint to grow and change according to an expected mode by changing the mechanics and the form of the microneedle patch.
The foregoing description is intended to be illustrative rather than limiting, and it will be appreciated by those skilled in the art that many modifications, variations or equivalents may be made without departing from the spirit and scope of the invention as defined in the appended claims.

Claims (2)

1. A microneedle patch for regulating and controlling mechanical action is characterized in that: the microneedle patch comprises a microneedle base layer (1) and a mechanical regulation layer (4);
the microneedle base layer (1) comprises microneedles (2) and a microneedle adhesion layer, wherein the microneedle adhesion layer is a base surface of the microneedles (2);
the mechanical regulation and control layer (4) and the microneedle attachment layer are fixed relative to the other side of the microneedle (2);
the mechanical regulation and control layer (4) consists of a base layer and a reinforcing rib layer (3) or a driving layer (5);
the mechanical effect of the microneedle base layer (1) can be controllably adjusted through the action change of the driving layer (5);
the driving layer (5) is connected with a driver, the driver drives the driving layer (5) to shrink towards the center direction or shrink in a single direction, the driving layer (5) is made of an electric shrinkage material or a pressure shrinkage structure and is driven by the external driver;
the driving layer (5) is provided with an electric shrinkage material or a pressure shrinkage structure which is integrally arranged, or is locally arranged in a strip shape according to a certain direction, or is arranged in a strip shape in a plurality of directions, so that the driving layer (5) moves according to a specific direction, the micro needle paste action is driven to change, and different mechanical action effects are achieved.
2. A microneedle patch for regulating and controlling mechanical action is characterized in that: the microneedle patch comprises a microneedle base layer (1) and a mechanical regulation layer (4);
the microneedle base layer (1) comprises microneedles (2) and a microneedle adhesion layer, wherein the microneedle adhesion layer is a base surface of the microneedles (2);
the mechanical regulation and control layer (4) and the microneedle attachment layer are fixed relative to the other side of the microneedle (2);
the mechanical regulation and control layer (4) consists of a base layer and a reinforcing rib layer (3) or a driving layer (5);
the base layer of the mechanical regulation and control layer (4) is a base surface of the mechanical regulation and control layer (4), one surface of the base layer is attached to the microneedle attachment layer, and the other surface of the base layer is used for fixing the reinforcing ribs (6);
or combining the microneedle attachment layer and the base layer into one;
or the microneedle patches are made of the same material and comprise the microneedles (2), the base layer and the reinforcing ribs (6), and the materials are degradable gel medical usable materials;
the reinforcing ribs (6) are straight lines or curved lines;
the section of the reinforcing rib (6) is semicircular, rectangular or square;
the length of the reinforcing rib (6) close to the base layer is greater than the length of the reinforcing rib far away from the base layer, and the width and the thickness of the section size of the reinforcing rib (6) are far smaller than the length size of the reinforcing rib;
the reinforcing ribs (6) are arranged in parallel, and the reinforcing ribs (6) are arranged at different angles;
the reinforcing ribs (6) are arranged in partial regions, and the partial regions are not arranged.
CN202110536394.2A 2021-05-17 2021-05-17 Microneedle patch for regulating and controlling mechanical action Active CN113198102B (en)

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Application Number Priority Date Filing Date Title
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CN113198102B true CN113198102B (en) 2023-04-07

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WO2014132239A1 (en) * 2013-02-28 2014-09-04 Kimberly-Clark Worldwide, Inc. Drug delivery device
CN106110491A (en) * 2016-07-22 2016-11-16 京东方科技集团股份有限公司 Administration device
CN110151736A (en) * 2019-07-04 2019-08-23 蚌埠医学院 Patch and preparation method thereof
CN211357412U (en) * 2019-05-17 2020-08-28 中国科学技术大学 Microneedle patch

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US20040068224A1 (en) * 2002-10-02 2004-04-08 Couvillon Lucien Alfred Electroactive polymer actuated medication infusion pumps
KR102369530B1 (en) * 2017-11-24 2022-03-03 주식회사 스몰랩 Micro needle and method of fabricating the same
EP3723610A1 (en) * 2017-12-15 2020-10-21 Koninklijke Philips N.V. Wearable or insertable devices with microneedles that include mechanically-responsive material
CN109011132B (en) * 2018-08-28 2022-03-22 京东方科技集团股份有限公司 Microneedle system drive structure and microneedle system
CN110935097B (en) * 2019-12-03 2021-10-29 广州新济薇娜生物科技有限公司 Microneedle patch for improving skin hypertrophic scar and preparation method thereof
CN114129543A (en) * 2021-12-01 2022-03-04 中国人民解放军陆军军医大学第一附属医院 Application of microneedle patch in regulating and controlling mechanical microenvironment of scar tissue

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014132239A1 (en) * 2013-02-28 2014-09-04 Kimberly-Clark Worldwide, Inc. Drug delivery device
CN106110491A (en) * 2016-07-22 2016-11-16 京东方科技集团股份有限公司 Administration device
CN211357412U (en) * 2019-05-17 2020-08-28 中国科学技术大学 Microneedle patch
CN110151736A (en) * 2019-07-04 2019-08-23 蚌埠医学院 Patch and preparation method thereof

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