CN113197925A

CN113197925A - Pharmaceutical composition, preparation method thereof, external medicine and application

Info

Publication number: CN113197925A
Application number: CN202110523157.2A
Authority: CN
Inventors: 郭亮生
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-05-13
Filing date: 2021-05-13
Publication date: 2021-08-03

Abstract

The embodiment of the invention relates to the field of medicines, and particularly discloses a pharmaceutical composition, a preparation method thereof, an external medicine and an application thereof, wherein the pharmaceutical composition comprises the following raw materials: borneol, pseudo-ginseng, angelica, starch and sodium bicarbonate. The pharmaceutical composition provided by the embodiment of the invention can be used for regulating rheumatoid diseases, rheumatic diseases, insomnia and diabetes by external use through matching the raw materials such as borneol, pseudo-ginseng, angelica, starch, sodium bicarbonate and the like, reduces toxic and side effects caused by oral administration, realizes external treatment of internal diseases, and solves the problem that most of the existing medicines for body regulation and rehabilitation have single function; the preparation method of the pharmaceutical composition provided by the embodiment of the invention is simple, and the pharmaceutical composition can be used as an external medicine to be spread on an affected part for massage and absorption, so that the effects of treatment and rehabilitation conditioning can be achieved, and the pharmaceutical composition has a wide market prospect.

Description

Pharmaceutical composition, preparation method thereof, external medicine and application

Technical Field

The embodiment of the invention relates to the field of medicines, and particularly relates to a pharmaceutical composition, a preparation method thereof, an external medicine and application thereof.

Background

Along with the continuous development of society, the attention of people on body conditioning and rehabilitation is also continuously improved. Diabetes is currently a group of metabolic diseases characterized by hyperglycemia, and generally requires drug treatment and general dietary conditioning. The obvious effect can be achieved only by long-time conditioning and rehabilitation of lumbago and leg pain, lumbar disc herniation, varicosity, chest distress and short breath, poor sleep and the like caused by rheumatism and rheumatoid, and higher requirements are provided for the performance of the medicine capable of realizing quick-acting rehabilitation.

At present, most of the existing rehabilitation medicines directly adopt single raw materials, such as ginseng, pilose antler and the like for conditioning and rehabilitation, the functions are single, for example, women often cause hyperplasia of mammary glands due to fatigue, irregular life, mental stress, excessive pressure and the like, serious hyperplasia of mammary glands often causes fever symptoms, and at the moment, the conventional medicines for conditioning hyperplasia of mammary glands cannot achieve good fever reducing effects.

Therefore, for the existing medicines for conditioning and rehabilitation of the body, the following defects exist in practical application: most of the existing medicines for conditioning and rehabilitation of bodies have the problem of single function.

Disclosure of Invention

The embodiment of the invention aims to provide a pharmaceutical composition, a preparation method thereof, an external medicine and application thereof, so as to solve the problem that most of the existing medicines for conditioning and rehabilitation of the body in the background art have single function.

In order to achieve the above purpose, the embodiments of the present invention provide the following technical solutions:

a pharmaceutical composition is prepared from Borneolum Syntheticum, Notoginseng radix, radix Angelicae sinensis, starch, and sodium bicarbonate by pulverizing into powder.

As a further scheme of the embodiment of the invention: the starch is amylose and/or amylopectin.

As a further scheme of the embodiment of the invention: the starch is any one of potato starch, mung bean starch, wheat starch, sweet potato starch, water chestnut starch, lotus root starch, corn starch, cassava powder and the like.

As a further scheme of the embodiment of the invention: the pharmaceutical composition comprises the following raw materials in parts by weight: 2-8 parts of borneol, 1-5 parts of pseudo-ginseng, 1-5 parts of angelica, 0.1-0.7 part of starch and 80-100 parts of sodium bicarbonate.

Another object of an embodiment of the present invention is to provide a method for preparing a pharmaceutical composition, which comprises the following steps: weighing borneol, pseudo-ginseng, angelica, starch and sodium bicarbonate according to the proportion, crushing and placing to obtain the medicinal composition.

Another object of the embodiments of the present invention is to provide a pharmaceutical composition for external use, which comprises the above-mentioned components partially or completely.

The other purpose of the embodiment of the invention is to provide the application of the externally applied medicine in preparing the medicine for treating rheumatoid diseases and/or rheumatic diseases and/or insomnia and/or diabetes.

Compared with the prior art, the embodiment of the invention has the beneficial effects that:

the pharmaceutical composition prepared by the embodiment of the invention can achieve the effect of conditioning rheumatoid diseases and/or rheumatic diseases and/or insomnia and/or diabetes by external use through the matching use of the raw materials such as borneol, pseudo-ginseng, angelica, starch, sodium bicarbonate and the like, reduces toxic and side effects caused by oral administration, realizes external treatment of internal diseases, and solves the problem that most of the existing medicines for conditioning and rehabilitation of bodies have single function; the preparation method of the pharmaceutical composition provided by the embodiment of the invention is simple, and the pharmaceutical composition can be used as an external medicine to be spread on an affected part for massage and absorption, so that the effects of treating and rehabilitating rheumatoid diseases and/or rheumatic diseases and/or insomnia and/or diabetes can be achieved, and the pharmaceutical composition has a wide market prospect.

Detailed Description

The present invention will be described in further detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the embodiments of the present invention, but are not intended to limit the embodiments of the present invention in any way. It should be noted that various changes and modifications can be made by those skilled in the art without departing from the spirit of the embodiments of the present invention. These are all within the scope of the embodiments of the present invention.

The pharmaceutical composition provided by the embodiment of the invention is prepared by crushing borneol, pseudo-ginseng, Chinese angelica, starch and sodium bicarbonate which are used as main raw materials into powder.

As another preferred embodiment of the present invention, the starch is amylose and/or amylopectin.

As another preferred example of the embodiment of the present invention, the starch is any one of potato starch, mung bean starch, wheat starch, sweet potato starch, water chestnut starch, lotus root starch, corn starch, tapioca starch, and the like.

Preferably, the starch is potato starch, which has the function of removing blood stasis and can provide potassium element for the body.

As another preferred embodiment of the present invention, the pharmaceutical composition comprises the following raw materials in parts by weight: 2-8 parts of borneol, 1-5 parts of pseudo-ginseng, 1-5 parts of angelica, 0.1-0.7 part of starch and 80-100 parts of sodium bicarbonate.

As another preferred embodiment of the present invention, the pharmaceutical composition comprises the following raw materials in parts by weight: 4-6 parts of borneol, 1.5-4 parts of pseudo-ginseng, 1.5-4 parts of angelica, 0.3-0.6 part of starch and 85-95 parts of sodium bicarbonate.

Preferably, the pharmaceutical composition comprises the following raw materials in parts by weight: 5 parts of borneol, 3 parts of pseudo-ginseng, 3 parts of angelica, 0.5 part of starch and 90 parts of sodium bicarbonate.

Preferably, the pharmaceutical composition comprises the following raw materials in parts by weight: 5 parts of borneol, 1.5 parts of pseudo-ginseng, 1.5 parts of angelica, 0.5 part of starch and 90 parts of sodium bicarbonate.

In the embodiments of the present invention, borneol, notoginseng, angelica, etc. are all named as traditional Chinese medicines. For example, borneol, a name of traditional Chinese medicine, is obtained by steam distillation and recrystallization of stems and leaves of blumea balsamifera of Compositae or branches and leaves of cinnamomum camphora of Lauraceae, and can be used for treating symptoms such as block pattern, coma, conjunctival congestion, sore throat, aphtha, sore and ulcer, unhealing after ulceration, and the like. Notoginseng radix, also called Notoginseng radix and Ginseng radix Notoginseng radix, is the dried root of Panax notoginseng of Araliaceae; warm in nature, sweet and slightly bitter in taste, enters liver and stomach meridians, and has the effects of removing blood stasis, stopping bleeding, promoting blood circulation and relieving pain; it can be used for treating hemorrhage, traumatic injury, and swelling and pain due to blood stasis. The Chinese angelica is the dry root of the Chinese angelica of the family Umbelliferae, has sweet and pungent taste and warm property and enters liver, heart and spleen channels; has the effects of enriching blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation; it is commonly used for blood deficiency and sallow complexion, vertigo and palpitation, irregular menstruation, amenorrhea and dysmenorrhea, deficiency cold and abdominal pain, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness and constipation.

The embodiment of the invention also provides a preparation method of the pharmaceutical composition, which specifically comprises the following steps:

weighing borneol, pseudo-ginseng, angelica, starch and sodium bicarbonate according to the proportion, crushing and placing to obtain the medicinal composition.

As another preferred embodiment of the embodiments of the present invention, in the method for preparing the pharmaceutical composition, the pulverizing is performed by pulverizing the borneol, the notoginseng, the angelica, the starch and the sodium bicarbonate into powders respectively and then mixing them uniformly, or by pulverizing the borneol, the notoginseng, the angelica, the starch and the sodium bicarbonate into powders together after mixing them uniformly. Of course, it is also possible to pulverize part of the raw materials of borneol, notoginseng, angelica, starch and sodium bicarbonate into powder respectively, mix them uniformly, and then pulverize them into powder together. The specific mode is selected according to the requirement, and is not limited herein as long as the powdery material is formed finally.

In other embodiments, the specific size of the pulverized material is selected according to the requirement, and is not limited herein, and may be, for example, powder, tablet, strip or even block, and preferably powder.

As another preferable example of the embodiment of the present invention, the time for the standing is not less than 48 hours. Preferably after stirring to mix well for 48 hours.

In the embodiment of the invention, as the pharmaceutical composition is externally used for treating patients, wounds and skin damages are forbidden, the embodiment of the invention only needs to spray the medicinal powder on the affected parts and massage and absorb the medicinal powder, thereby not only having the functions of mainly treating hyperplasia of mammary glands and reducing fever, but also conditioning: the Chinese medicinal composition has the advantages of simple use mode, no need of oral administration, avoidance of toxic and side effects caused by oral administration, and achievement of rehabilitation treatment of related diseases through skin.

The embodiment of the invention also provides a pharmaceutical composition prepared by the preparation method of the pharmaceutical composition.

The embodiment of the invention also provides application of the pharmaceutical composition in preparing medicines for treating and rehabilitating and conditioning the rheumatoid diseases and/or the rheumatic diseases and/or the insomnia and/or the diabetes.

The embodiment of the invention also provides an external medicament, which partially or completely comprises the medicinal composition.

As another preferred embodiment of the present invention, the formulation of the external preparation is any one of powder, fumigant, or spray.

As another preferred embodiment of the present invention, when the external preparation is powder, the external preparation is used for treating patients, and the wound and skin breakage are not treated, and the external preparation is applied by spreading the pharmaceutical composition on the affected part, massaging and absorbing.

The embodiment of the invention also provides application of the externally applied medicine in preparing medicines for treating rheumatoid diseases and/or rheumatic diseases and/or insomnia and/or diabetes.

As another preferred embodiment of the present invention, in the application of the external medicine in the preparation of the medicine for treating rheumatoid diseases and/or rheumatic diseases and/or insomnia and/or diabetes, specifically, borneol, notoginseng, angelica, starch (preferably potato starch) and sodium bicarbonate are all made into powder, and then mixed to make the external medicine, i.e. borneol powder, notoginseng powder, angelica powder, potato starch and sodium bicarbonate powder are used as raw materials and are uniformly stirred for 48 hours; wherein, the pseudo-ginseng powder has the following functions: promoting blood circulation, removing blood stasis, relieving swelling and pain, relieving fatigue, resisting aging, and regulating hypertension, hyperglycemia and hyperlipidemia, and can be used for regulating diabetes by matching with sodium bicarbonate; the angelica powder has the following functions: promoting blood circulation, relieving pain, regulating blood stasis, chest distress, short breath and rheumatism, strengthening tendons and bones, improving insomnia, resisting arteriosclerosis, and regulating immune system; the borneol powder has the following functions: clearing heat, relieving pain, inducing resuscitation, refreshing mind, regulating heart disease, and removing stagnated fire; the sodium bicarbonate functions here as: anti-aging, regulating heart recurrence, regulating moisture; the potato starch functions here as: removing blood stasis, and supplying potassium element to body. The manufacturing process is simple, and the market prospect is wide.

The technical effects of the pharmaceutical composition of the present invention will be further described below by way of specific examples.

Example 1

In this example, a pharmaceutical composition is prepared as follows:

weighing 50g of borneol powder, 30g of pseudo-ginseng and Chinese angelica, 5g of potato starch and 900g of sodium bicarbonate powder, and stirring uniformly for 48 hours.

In this embodiment, the prepared pharmaceutical composition can be applied topically to treat wounds and skin lesions, and can be applied by spreading the pharmaceutical composition on the affected area, massaging and absorbing. Wherein, the pseudo-ginseng powder has the following functions: promoting blood circulation, removing blood stasis, relieving swelling and pain, relieving fatigue, resisting aging, and regulating hypertension, hyperglycemia and hyperlipidemia, and can be used for regulating diabetes by matching with sodium bicarbonate; the angelica powder has the following functions: promoting blood circulation, relieving pain, regulating blood stasis, chest distress, short breath and rheumatism, strengthening tendons and bones, improving insomnia, resisting arteriosclerosis, and regulating immune system; the borneol powder has the following functions: clearing heat, relieving pain, inducing resuscitation, refreshing mind, regulating heart disease, and removing stagnated fire; the sodium bicarbonate functions here as: resisting aging, regulating heart recurrence, and regulating qi regulation due to dampness; the potato starch functions here as: removing blood stasis, and supplying potassium element to body.

Example 2

The same procedure as in example 1 was repeated, except that 20g of the powdered borneol was used in comparison with example 1.

Example 3

The same procedure as in example 1 was repeated, except that the amount of the fine ice flakes used was 80g as compared with example 1.

Example 4

A pharmaceutical composition comprising the following raw materials: borneol 2g, notoginseng 1g, Chinese angelica root 1g, starch 0.1g and sodium bicarbonate 80 g. Wherein the starch is potato starch.

In this example, the pharmaceutical composition is prepared as follows:

weighing the borneol, the pseudo-ginseng, the angelica, the starch and the sodium bicarbonate, respectively crushing the borneol, the pseudo-ginseng, the angelica, the starch and the sodium bicarbonate into powder, uniformly mixing, and standing for 48 hours to obtain the pharmaceutical composition.

Example 5

A pharmaceutical composition comprising the following raw materials: 8g of borneol, 5g of pseudo-ginseng, 5g of angelica, 0.7g of starch and 100g of sodium bicarbonate. Wherein the starch is potato starch.

In this example, the pharmaceutical composition is prepared as follows:

weighing the borneol, the pseudo-ginseng, the angelica, the starch and the sodium bicarbonate, uniformly mixing, then jointly crushing into powder, and standing for 60 hours to obtain the pharmaceutical composition.

Example 6

Compared to example 5, except that the raw materials of the pharmaceutical composition include: 4g of borneol, 1.5g of pseudo-ginseng, 1.5g of angelica, 0.3g of starch and 85g of sodium bicarbonate. The rest is the same as in example 5.

Example 7

Compared to example 5, except that the raw materials of the pharmaceutical composition include: 6g of borneol, 4g of pseudo-ginseng, 4g of angelica, 0.6g of starch and 95g of sodium bicarbonate. The rest is the same as in example 5.

Example 8

Compared to example 5, except that the raw materials of the pharmaceutical composition include: 5g of borneol, 3g of pseudo-ginseng, 3g of angelica, 0.5g of potato starch and 90g of sodium bicarbonate. The rest is the same as in example 5.

Example 9

Compared to example 5, except that the raw materials of the pharmaceutical composition include: 5g of borneol, 1.5g of pseudo-ginseng, 1.5g of angelica, 0.5g of potato starch and 90g of sodium bicarbonate. The rest is the same as in example 5.

Example 10

Compared to example 5, except that the raw materials of the pharmaceutical composition include: 4.5g of borneol, 2g of pseudo-ginseng, 2g of angelica, 0.5g of potato starch and 90g of sodium bicarbonate. The rest is the same as in example 5.

Example 11

The same as example 1 except that the starch was amylose, compared to example 1.

Example 12

The same as example 1 except that the starch was amylopectin, as compared with example 1.

Example 13

The procedure of example 1 was repeated except that the starch was a mixture of amylose and amylopectin by weight.

Example 14

The same as example 1 except that the starch was mung bean starch, as compared with example 1.

Example 15

The same as example 1 except that the starch was wheat starch, as compared with example 1.

Example 16

The same as example 1 except that the starch was sweet potato starch, as compared with example 1.

Example 17

The same as example 1 except that the starch is water chestnut starch, as compared with example 1.

Example 18

The same as example 1 except that the starch was lotus root starch, compared to example 1.

Example 19

The same as example 1 except that the starch was corn starch, as compared with example 1.

Example 20

The same as example 1 except that the starch was tapioca as compared with example 1.

Example 21

The same as example 1 was repeated, except that the pharmaceutical composition was used as it is (in the form of fumigant) for external use as compared with example 1.

Example 22

The same as example 1 was repeated except that the pharmaceutical composition was used as it is (in the form of a spray) for external use as compared with example 1.

Modern medicine has thought that rheumatoid arthritis, rheumatoid arthritis and the like often cause a series of clinical symptoms such as red swelling, pain and the like. The embodiment of the invention can be used for applying the pharmaceutical composition to the affected part and massaging and absorbing the pharmaceutical composition, so that the pharmaceutical composition not only has the functions of mainly treating hyperplasia of mammary glands and reducing fever, but also can be used for conditioning symptoms such as low back pain and leg pain, lumbar disc herniation, varicosity, chest distress and short breath, poor sleep and the like caused by rheumatism and rheumatoid, has a simple use mode, and can achieve the aim of rehabilitation treatment of related diseases through skin.

While the preferred embodiments of the present invention have been described in detail, the embodiments of the present invention are not limited to the above embodiments, and various changes can be made without departing from the spirit of the embodiments of the present invention within the knowledge of those skilled in the art. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications of the invention may be made without departing from the scope of the invention.

Claims

1. A pharmaceutical composition is characterized in that the pharmaceutical composition is prepared by processing at least borneol, pseudo-ginseng, angelica, starch and sodium bicarbonate as main raw materials.

2. The pharmaceutical composition according to claim 1, wherein the starch is amylose and/or amylopectin.

3. The pharmaceutical composition of claim 2, wherein the starch is any one of potato starch, mung bean starch, wheat starch, sweet potato starch, water chestnut starch, lotus root starch, and corn starch.

4. The pharmaceutical composition according to claim 1, wherein the pharmaceutical composition comprises the following raw materials in parts by weight: 2-8 parts of borneol, 1-5 parts of pseudo-ginseng, 1-5 parts of angelica, 0.1-0.7 part of starch and 80-100 parts of sodium bicarbonate.

5. The pharmaceutical composition according to claim 1, wherein the pharmaceutical composition comprises the following raw materials in parts by weight: 4-6 parts of borneol, 1.5-4 parts of pseudo-ginseng, 1.5-4 parts of angelica, 0.3-0.6 part of starch and 85-95 parts of sodium bicarbonate.

6. A process for the preparation of a pharmaceutical composition according to any one of claims 1 to 5, comprising the steps of: weighing borneol, pseudo-ginseng, angelica, starch and sodium bicarbonate according to the proportion, crushing and placing to obtain the medicinal composition.

7. The method for preparing the pharmaceutical composition according to claim 6, wherein the pulverizing is performed by pulverizing the borneol, the notoginseng, the angelica, the starch and the sodium bicarbonate into powder respectively and then mixing them uniformly, or by pulverizing the borneol, the notoginseng, the angelica, the starch and the sodium bicarbonate into powder together after mixing them uniformly.

8. A topical medicament comprising, in part or in whole, a pharmaceutical composition as claimed in any one of claims 1 to 5.

9. The external preparation as defined in claim 8, wherein the external preparation is in the form of powder, fumigant or spray.

10. Use of an external medicament as claimed in any one of claims 8 to 9 in the manufacture of a medicament for the treatment of rheumatoid disease and/or rheumatic disease and/or insomnia and/or diabetes.