CN113171395A

CN113171395A - Skin antibacterial cream and preparation method thereof

Info

Publication number: CN113171395A
Application number: CN202110507926.XA
Authority: CN
Inventors: 不公告发明人
Original assignee: Xinjiang Made Looz Biotechnology Co ltd
Current assignee: Xinjiang Made Looz Biotechnology Co ltd
Priority date: 2021-05-10
Filing date: 2021-05-10
Publication date: 2021-07-27

Abstract

The invention discloses a skin bacteriostatic cream and a preparation method thereof, wherein the skin bacteriostatic cream is dissolved by the following steps: dissolving beeswax in a water bath kettle at 60 ℃ for later use; stirring the vegetable oil: pouring olive fruit oil, sesame oil, black grass seed oil, clove essential oil, lithospermum oil, seabuckthorn fruit oil, pistachio oil, walnut oil, pomegranate seed oil and shea butter into a sandwich stirring pot with a heating function, heating to 40-50 ℃ while stirring, stirring for 6-8H, and standing for 2H while keeping the temperature; stirring the mixture: pouring the dissolved beeswax into an interlayer stirring pot, continuously stirring for 2H, cooling to 35 ℃, slowly adding parachlorometaxylenol, and uniformly stirring; filtering and filling: and filtering the fully stirred mixture and filling to obtain a finished product. The skin antibacterial cream is very suitable for the skin of people living in dry climate of Xinjiang due to high oil content, is rich in vitamin E grease, not only nourishes the skin, but also forms a layer of protective film on the skin, and has the effects of shrinking and moistening, inhibiting bacteria and relieving itching.

Description

Skin antibacterial cream and preparation method thereof

Technical Field

The invention relates to the technical field of medicinal preparations, in particular to a skin bacteriostatic cream and a preparation method thereof.

Background

Uygur medicine is a medical system created by the continuous struggle of Uygur ancestors and ancient Uygur people with diseases in the long history period, living at the west edge of China-Xinjiang. Has rich experience and unique theory, and is one of the important components of Chinese traditional medicine. For short, Wei medicine or Wei medicine. The unique diagnosis and treatment and peculiar curative effect on certain diseases play a great role in the innovation and the multiplication of the nation.

The traditional Chinese medicine preparation is a medicine which is processed and prepared by taking traditional Chinese medicines as raw materials under the guidance of the traditional Chinese pharmacology theory, has a certain specification and can be directly used for preventing and treating diseases. The most representative traditional dosage forms are pills, powder, ointment and pellets. For thousands of years, the traditional Chinese medicine preparation accumulates abundant experience in the medical practice of doctors of all generations, forms a unique preparation technology and is an important component in the traditional Chinese medicine treasury.

Because of the special local environment of Xinjiang and dry climate, the skin of people living in Xinjiang is easy to be dry and itchy and rough, and the prior bacteriostatic cream for skin is difficult to moisten the skin of people in the area because of low oil content.

Disclosure of Invention

The invention aims to provide a skin bacteriostatic cream and a preparation method thereof, which can solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

the skin bacteriostatic cream comprises the following formula in percentage by volume:

1.3 percent of parachlorometaxylenol, 10 to 20 percent of olive oil, 5 to 10 percent of sesame oil, 20 to 30 percent of black grass seed oil, 0.2 to 0.5 percent of clove essential oil, 1 to 2 percent of lithospermum oil, 1 to 2 percent of sea buckthorn fruit oil, 5 to 8 percent of pistachio oil, 5 to 8 percent of walnut oil, 5 to 8 percent of pomegranate seed oil, 15 to 25 percent of shea butter and the balance of beeswax.

The parachlorometaxylenol is an organic compound, has a molecular formula of C8H9CIO, is stable in chemical property, and is easily soluble in organic solvents such as alcohol, ether, polyglycol and the like and strong alkaline aqueous solution. It is a broad-spectrum mildew-proof antibacterial agent, and has killing effect on most gram-positive and gram-negative bacteria, fungi and mould.

The olive fruit oil contains various nutrient components required by human body, does not contain essence and chemical substances, and the fatty acid and various natural fat-soluble vitamins thereof are very beneficial to moistening skin, and the olive oil skin care oil can be directly applied to prevent skin wrinkles and rough skin, so that the skin recovers natural elasticity, is glossy and delicate, and has special absorption capacity to ultraviolet rays.

Sesame oil is a sun-screening and isolating cream with high-concentration nutrition, the nutrient substances contained in the cream can effectively prevent the skin from being damaged by sunlight and ultraviolet rays, and a small amount of sesame oil is smeared on the surface of the skin to effectively form a protective film, so that the cream can resist ultraviolet radiation and isolate harmful substances and dust in the air, and has an excellent protective effect on the skin. The sesame oil can be a pure natural nutritional humectant which is rich in moisturizing factors and can prevent skin from drying and peeling, and the sesame oil can play a good role in moisturizing and locking water when being smeared on the surface of the skin in autumn and winter or used as a mask. The skin care product also has a great help effect on relieving the problems of skin itching, redness and swelling and the like caused by dryness.

The black grass seed oil is an oil which is rich in nutrients, but very light and smooth, and has a very luxurious feeling on the skin, and can be quickly absorbed when being used on the face. Despite its deep moisturizing effect, it can nourish, soothe, soften dry skin, and improve eczema, psoriasis, dermatitis, and acne. The oil is absolutely excellent overnight repair and care oil, can promote cell regeneration and delay skin aging, has antioxidant effect, and is suitable for damaged skin, dry skin and aged skin. The improvement on the allergic skin is excellent. And its effect can be manifested only by a small amount. The regular use can greatly improve the integral condition of skin and increase the density and softness of the skin.

The clove essential oil contains most natural components in the plant clove, has a certain medicinal value, can eliminate inflammation and bacterial diseases when being smeared on skin, can prevent various fungi from breeding and can prevent skin inflammation, and in addition, when people suffer from skin pain and itch or skin red swelling, a proper amount of clove essential oil is directly smeared and massaged, so that swelling and pain can be relieved, and the state of an illness can be quickly relieved.

The lithospermum is also called as the root of lithospermum erythrorhizon, purple , sanguinea and the like, is the root of lithospermum erythrorhizon, new Tibetan pseudo lithospermum or onosma paniculatum of the alkanaceae, has the effects of clearing heat and cooling blood, is lithospermum oil extracted and refined from the root of the lithospermum, is fragrant, refreshing and breathable, can repair discomfort such as skin itching, redness and the like, and can also prevent and treat skin problems such as diaper rash, skin ulceration, eczema and the like of babies. The lithospermum skin care oil has the advantages of moistening and not being greasy, deeply nourishing and being easy to absorb, mildly caring the skin lipid membrane and conditioning the skin.

The free fatty acid in the seabuckthorn oil is easily absorbed by the skin, so that the skin elasticity is increased, and the VC rich in the free fatty acid can reduce the melanin deposition of the skin and clean and whiten the skin. The seabuckthorn oil also has the effects of promoting blood circulation, removing blood stasis, promoting blood vessel circulation, improving metabolism and keeping skin smooth and tender.

The pistachio contains more tannin, and also contains anthocyanin galactoside, anthocyanin glucoside, lutein and the like. It has effects in scavenging free radicals, and can be used as antioxidant to prevent aging; has antibacterial effect on Escherichia coli, Staphylococcus aureus, and Streptococcus albus, and can be used as antiinflammatory agent.

The walnut oil is beneficial to keeping moisture, moistening and nourishing skin, eliminating and delaying the appearance of wrinkles and slowing down the aging degree of the skin. Can prevent ultraviolet ray from damaging skin and avoid sunburn, skin explosion and desquamation. In winter, the walnut oil is used for wiping face, lips and hands and feet, so that the skin can be moistened and protected, and the roughness and the dryness can be prevented.

The obtained product has strong oxidation resistance, can effectively resist inflammation and oxygen free radical damage, and can be used as additive for high-grade cosmetics, and has effects in whitening skin, removing wrinkle, delaying aging, preventing atherosclerosis and slowing canceration process.

Shea butter can promote the regeneration and renewal of skin by promoting the activity of epidermal cells, thereby stopping and reversing the typical symptoms of skin aging such as wrinkles, canthus wrinkles and skin laxity! As the aging phenomenon disappears, the facial skin becomes smooth and tight.

Cera flava has strong moistening effect, and has effects of removing necrotic tissue and promoting granulation.

Further, the formula comprises the following components in percentage by volume:

1.3% of parachlorometaxylenol, 20% of olive oil, 8% of sesame oil, 30% of black cumin seed oil, 0.4% of clove essential oil, 1% of lithospermum oil, 1% of seabuckthorn fruit oil, 6% of pistachio oil, 5% of walnut oil, 6% of pomegranate seed oil, 20% of shea butter and the balance beeswax.

1.3% of parachlorometaxylenol, 10% of olive oil, 10% of sesame oil, 20% of black cumin seed oil, 0.2% of clove essential oil, 2% of lithospermum oil, 2% of sea buckthorn fruit oil, 8% of pistachio nut oil, 8% of walnut oil, 5% of pomegranate seed oil, 25% of shea butter and the balance beeswax.

1.3% of parachlorometaxylenol, 15% of olive oil, 5% of sesame oil, 25% of black-seed grass seed oil, 0.5% of clove essential oil, 1.5% of lithospermum oil, 1.5% of sea buckthorn fruit oil, 5% of pistachio nut oil, 8% of walnut oil, 8% of pomegranate seed oil, 25% of shea butter and the balance of beeswax.

1.3% of parachlorometaxylenol, 20% of olive oil, 10% of sesame oil, 30% of black cumin seed oil, 0.3% of clove essential oil, 2% of lithospermum oil, 2% of seabuckthorn fruit oil, 6% of pistachio oil, 6% of walnut oil, 6% of pomegranate seed oil, 15% of shea butter and the balance beeswax.

The invention provides another technical scheme that: a preparation method of a skin antibacterial cream comprises the following steps:

s1: dissolving: dissolving beeswax in a water bath kettle at 60 ℃ for later use;

s2: stirring the vegetable oil: pouring olive fruit oil, sesame oil, black grass seed oil, clove essential oil, lithospermum oil, seabuckthorn fruit oil, pistachio oil, walnut oil, pomegranate seed oil and shea butter into a sandwich stirring pot with a heating function, heating to 40-50 ℃ while stirring, stirring for 6-8H, and standing for 2H while keeping the temperature;

s3: stirring the mixture: pouring the dissolved beeswax into an interlayer stirring pot, continuously stirring for 2H, finally, cooling to 35 ℃, slowly adding parachlorometaxylenol, and uniformly stirring;

s4: filtering and filling: and filtering the fully stirred mixture and filling to obtain a finished product.

Further, parachlorometaxylenol of S3 was dissolved in sesame oil in advance.

Compared with the prior art, the invention has the beneficial effects that:

the formula of the invention adopts olive fruit oil, sesame oil, black grass seed oil for cultivation, clove essential oil, lithospermum oil, sea buckthorn fruit oil, pistachio nut oil, walnut oil, pomegranate seed oil and shea butter, and is very suitable for the skin of people living in dry climates like Xinjiang due to high oil content, and the skin is not only nourished but also forms a layer of protective film on the skin, so that the skin is shrunk and moistened, and is bacteriostatic and antipruritic.

Drawings

FIG. 1 is a flow chart of the preparation process of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

As shown in the flow chart of fig. 1, the beeswax is dissolved in a water bath at 60 ℃ for standby; pouring 1.3% of parachlorometaxylenol, 20% of olive oil, 8% of sesame oil, 30% of black grass seed oil, 0.4% of clove essential oil, 1% of lithospermum oil, 1% of sea buckthorn fruit oil, 6% of pistachio oil, 5% of walnut oil, 6% of pomegranate seed oil and 20% of shea butter into a sandwich stirring pot with a heating function, heating to 40-50 ℃ while stirring, stirring for 6-8H, preserving heat and standing for 2H; pouring the dissolved beeswax into a jacketed stirring pot, continuously stirring for 2H, finally, cooling the temperature to 35 ℃, slowly adding parachlorometaxylenol (dissolved in sesame oil in advance, the parachlorometaxylenol is generally completely dissolved in base oil such as sesame oil and olive oil), and uniformly stirring; and filtering the fully stirred mixture and filling to obtain a finished product.

Example 2

Dissolving beeswax in a water bath kettle at 60 ℃ for later use; pouring 10% of olive oil, 10% of sesame oil, 20% of black grass seed oil, 0.2% of clove essential oil, 2% of lithospermum oil, 2% of sea buckthorn fruit oil, 8% of pistachio nut oil, 8% of walnut oil, 5% of pomegranate seed oil and 25% of shea butter into a sandwich stirring pot with a heating function, heating to 40-50 ℃ while stirring, stirring for 6-8H, preserving heat and standing for 2H; pouring the dissolved beeswax into a jacketed stirring pot, continuously stirring for 2H, finally, cooling the temperature to 35 ℃, slowly adding parachlorometaxylenol (dissolved in sesame oil in advance, the parachlorometaxylenol is generally completely dissolved in base oil such as sesame oil and olive oil), and uniformly stirring; and filtering the fully stirred mixture and filling to obtain a finished product.

Example 3

Dissolving beeswax in a water bath kettle at 60 ℃ for later use; pouring 15% of olive fruit oil, 5% of sesame oil, 25% of black grass seed oil, 0.5% of clove essential oil, 1.5% of lithospermum oil, 1.5% of sea buckthorn fruit oil, 5% of pistachio oil, 8% of walnut oil, 8% of pomegranate seed oil and 25% of shea butter into a sandwich stirring pot with a heating function, heating to 40-50 ℃ while stirring, stirring for 6-8H, and standing for 2H while keeping the temperature; pouring the dissolved beeswax into a jacketed stirring pot, continuously stirring for 2H, finally, cooling the temperature to 35 ℃, slowly adding parachlorometaxylenol (dissolved in sesame oil in advance, the parachlorometaxylenol is generally completely dissolved in base oil such as sesame oil and olive oil), and uniformly stirring; and filtering the fully stirred mixture and filling to obtain a finished product.

Example 4

Dissolving beeswax in a water bath kettle at 60 ℃ for later use; pouring 20% of olive oil, 10% of sesame oil, 30% of black grass seed oil, 0.3% of clove essential oil, 2% of lithospermum oil, 2% of sea buckthorn fruit oil, 6% of pistachio oil, 6% of walnut oil, 6% of pomegranate seed oil and 15% of shea butter into a sandwich stirring pot with a heating function, heating to 40-50 ℃ while stirring, stirring for 6-8H, and keeping the temperature and standing for 2H; pouring the dissolved beeswax into a jacketed stirring pot, continuously stirring for 2H, finally, cooling the temperature to 35 ℃, slowly adding parachlorometaxylenol (dissolved in sesame oil in advance, the parachlorometaxylenol is generally completely dissolved in base oil such as sesame oil and olive oil), and uniformly stirring; and filtering the fully stirred mixture and filling to obtain a finished product.

Control group: traditional antibacterial cream.

The bacteriostatic cream prepared in examples 1 to 4 was yellowish to orange-yellow paste, had no foreign substances visible to the naked eye, and had a specific odor.

(1) Bacteriostatic experiments were performed on the bacteriostatic creams prepared in examples 1 to 4 and the bacteriostatic cream of the control group, and the data shown in table 1 below were obtained.

As can be seen from Table 1, the bacteriostatic pastes of examples 1-4 using the formulation of the present invention are significantly superior to the conventional bacteriostatic paste in terms of bacteriostatic properties.

(2) The bacteriostatic creams prepared in examples 1 to 4 and the bacteriostatic cream of the control group were subjected to a microorganism quantity detection experiment to obtain the data shown in the following table 2.

As can be seen from Table 2, the bacteriostatic creams of examples 1-4 using the formulation of the present invention exhibited significantly less microbial numbers than the conventional bacteriostatic creams.

(3) The results of testing parachlorometaxylenol of the bacteriostatic pastes prepared in examples 1-4 are as follows:

as can be seen from Table 3, after the bacteriostatic pastes prepared in examples 1 to 4 were stored in a constant temperature and humidity chamber at 37 ℃ for 90 days, the content of parachlorometaxylenol was 0.155% as determined by high performance liquid chromatography, the reduction rate was 1.9%, and the test results met the requirements of "Disinfection technical Specification" (2002 edition).

The formula provided by the invention can effectively inhibit staphylococcus aureus. Colibacillus and candida albicans, and has the functions of reducing the infection of the skin from external harmful microorganisms and providing more protection for the skin.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be able to cover the technical solutions and the inventive concepts of the present invention within the technical scope of the present invention.

Claims

1. The skin bacteriostatic cream is characterized by comprising the following formula in percentage by volume:

2. The skin bacteriostatic cream according to claim 1, which comprises the following formula in percentage by volume:

3. The skin bacteriostatic cream according to claim 1, which comprises the following formula in percentage by volume:

4. The skin bacteriostatic cream according to claim 1, which comprises the following formula in percentage by volume:

5. The skin bacteriostatic cream according to claim 1, which comprises the following formula in percentage by volume:

6. A method for preparing a skin bacteriostatic cream according to claim 1, which is characterized by comprising the following steps:

7. A method for preparing a skin bacteriostatic cream according to claim 6 wherein the parachlorometaxylenol of S3 is dissolved in sesame oil in advance.