CN113144376B - Nanometer double-resistance deep vein catheter - Google Patents
Nanometer double-resistance deep vein catheter Download PDFInfo
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- CN113144376B CN113144376B CN202110413656.6A CN202110413656A CN113144376B CN 113144376 B CN113144376 B CN 113144376B CN 202110413656 A CN202110413656 A CN 202110413656A CN 113144376 B CN113144376 B CN 113144376B
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- 210000003462 vein Anatomy 0.000 title claims abstract description 153
- 238000001990 intravenous administration Methods 0.000 claims abstract description 69
- 239000003814 drug Substances 0.000 claims abstract description 39
- 230000002924 anti-infective effect Effects 0.000 claims abstract description 11
- 229940079593 drug Drugs 0.000 claims description 21
- 230000000007 visual effect Effects 0.000 claims description 4
- 229940127217 antithrombotic drug Drugs 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 11
- 208000007536 Thrombosis Diseases 0.000 abstract description 7
- 208000015181 infectious disease Diseases 0.000 abstract description 5
- 230000009977 dual effect Effects 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 description 18
- 239000007924 injection Substances 0.000 description 18
- 238000010041 electrostatic spinning Methods 0.000 description 11
- 229940121363 anti-inflammatory agent Drugs 0.000 description 8
- 239000002260 anti-inflammatory agent Substances 0.000 description 8
- 230000002785 anti-thrombosis Effects 0.000 description 8
- 239000000203 mixture Substances 0.000 description 6
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 229960002897 heparin Drugs 0.000 description 4
- 229920000669 heparin Polymers 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 4
- 229960001225 rifampicin Drugs 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000001741 anti-phlogistic effect Effects 0.000 description 3
- 239000003146 anticoagulant agent Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 description 3
- 229960004023 minocycline Drugs 0.000 description 3
- 239000002121 nanofiber Substances 0.000 description 3
- 238000013268 sustained release Methods 0.000 description 3
- 239000012730 sustained-release form Substances 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 206010040007 Sense of oppression Diseases 0.000 description 1
- 229960004676 antithrombotic agent Drugs 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
Abstract
The invention provides a nano double-resistance deep venous catheter, which is characterized in that: comprises a deep vein catheter body; the deep vein catheter body consists of a deep vein catheter main body, a deep vein catheter outer slow release layer and a deep vein catheter inner slow release layer; a deep vein catheter body having a central tube; the deep vein catheter outer slow release layer is positioned on the outer surface of the deep vein catheter main body; the deep intravenous catheter inner slow release layer is positioned on the inner surface of the deep intravenous catheter main body; a deep vein catheter outer slow release layer for slowly releasing the medicine with anti-infection and/or anti-thrombus effect; a slow-release layer in the deep vein catheter for slowly releasing the medicine with anti-infection and/or anti-thrombus effect. The catheter has the dual functions of resisting infection and thrombus, and the deep intravenous catheter can prolong the catheterization time and reduce the damage to the body of a patient by reducing the infection and thrombus formation of the patient.
Description
Technical Field
The invention relates to a medical apparatus, in particular to a nano double-resistance deep venous catheter.
Background
The clinical deep intravenous catheter is mainly used for fluid infusion and medication of critical patients and perioperative patients, but the catheter placement time is not too long, the risks of infection and thrombus are increased, the puncture catheter must be replaced generally according to different puncture parts for 5-14 days, the puncture catheter is an invasive operation, and the risks of bleeding and infection of the patients are increased due to frequent replacement.
Disclosure of Invention
The present invention aims to overcome the above-mentioned drawbacks and provide an anti-infective and antithrombotic intravenous catheter with dual functions, which not only can prolong the catheterization time, but also can reduce the damage to the body of the patient by reducing the infection and thrombosis of the patient.
The invention provides a nano double-resistance deep venous catheter, which is characterized in that: comprises a deep vein catheter body;
the deep vein catheter body consists of a deep vein catheter main body, a deep vein catheter outer slow-release layer and a deep vein catheter inner slow-release layer;
the deep vein catheter main body is provided with a middle through pipe;
the outer slow release layer of the deep vein catheter is positioned on the outer surface of the main body of the deep vein catheter;
the slow release layer in the deep vein catheter is positioned on the inner surface of the main body of the deep vein catheter;
the outer slow release layer of the deep vein catheter is used for slowly releasing the medicine with anti-infection and/or antithrombotic effects;
the slow release layer in the deep vein catheter can slowly release the medicine with anti-infection and/or anti-thrombosis effects.
According to the practical requirement, the two ends of the deep vein catheter body can be of a conventional intravenous tube structure, and generally, the tail ends (namely, the end which is deep into the injection part of a patient) of the deep vein catheter body are connected with a protective headgear, and the headgear is removed before use, so that the tail ends of the outer slow release layer and the inner slow release layer of the deep vein catheter can be of a closed structure or an open structure. The head end of the body is connected with a plurality of liquid input ends, and the storage, protection and control of the multiple pipelines are realized through the multi-way protection structure.
Considering the slow release effect and cost of the medicine, the outer slow release layer and the inner slow release layer of the deep vein catheter are generally covered and slightly longer than the traditional use length/built-in length.
Further, the nano double-resistance deep venous catheter provided by the invention is further characterized in that: the outer slow release layer of the deep vein catheter is a sleeve structure nested outside the main body of the deep vein catheter;
the outer visual surface of the deep vein catheter outer slow release layer is densely provided with nano-scale through holes;
the medicine with anti-infection and/or antithrombotic effect is filled between the deep vein catheter outer slow release layer and the deep vein catheter main body.
Further, the nano double-resistance deep venous catheter provided by the invention is further characterized in that: the slow release layer in the deep vein catheter is a sleeve structure nested in the deep vein catheter main body;
the inner view surface of the slow release layer in the deep vein catheter is densely provided with nano through holes;
the medicine with anti-infection and/or anti-thrombosis effect is filled between the slow release layer in the deep vein catheter and the main body of the deep vein catheter.
Further, the nano double-resistance deep venous catheter provided by the invention is further characterized in that: the deep vein catheter outer slow-release layer comprises a first deep vein catheter outer slow-release layer and a second deep vein catheter outer slow-release layer;
the first deep vein catheter outer slow release layer and the second deep vein catheter outer slow release layer are independently arranged on the outer surface of the deep vein catheter main body;
different medicines are filled in the first deep vein catheter outer slow release layer and the second deep vein catheter outer slow release layer.
Further, the nano double-resistance deep venous catheter provided by the invention is further characterized in that: the first deep vein catheter outer slow release layer and the second deep vein catheter outer slow release layer are independent from each other and are spirally arranged on the outer surface of the deep vein catheter main body;
or (b)
The first deep vein catheter outer slow release layer and the second deep vein catheter outer slow release layer are independent from each other and are arranged on the outer surface of the deep vein catheter main body in an staggered mode.
Further, the nano double-resistance deep venous catheter provided by the invention is further characterized in that: the slow-release layer in the deep vein catheter comprises a first slow-release layer in the deep vein catheter and a second slow-release layer in the deep vein catheter;
the first deep intravenous catheter inner slow release layer and the second deep intravenous catheter inner slow release layer are independently arranged on the inner surface of the deep intravenous catheter main body;
different medicines are filled in the first deep intravenous catheter inner slow release layer and the second deep intravenous catheter inner slow release layer.
Further, the nano double-resistance deep venous catheter provided by the invention is further characterized in that: the first deep intravenous catheter inner slow release layer and the second deep intravenous catheter inner slow release layer are independent from each other and are spirally arranged on the inner surface of the deep intravenous catheter main body;
or (b)
The first deep intravenous catheter inner slow release layer and the second deep intravenous catheter inner slow release layer are independent and staggered and arranged on the inner surface of the deep intravenous catheter main body.
Further, the nano double-resistance deep venous catheter provided by the invention is further characterized in that: the outer slow release layer of the deep vein catheter is of a reticular medicine carrying structure;
the net-shaped medicine carrying structure is manufactured by adopting an electrostatic spinning process.
Further, the nano double-resistance deep venous catheter provided by the invention is further characterized in that: the slow release layer in the deep intravenous catheter is of a net-shaped medicine carrying structure;
the net-shaped medicine carrying structure is manufactured by adopting an electrostatic spinning process.
Drawings
Fig. 1 is a schematic structural diagram of a nano dual anti-deep venous catheter according to the present embodiment;
fig. 2 is a schematic cross-sectional view of the tube body of the nano double-resistance deep venous catheter provided in this embodiment 1;
fig. 3 is a schematic structural diagram of a tube portion of the nano double-resistance deep venous catheter provided in embodiment 2;
fig. 4 is a schematic structural diagram of a tube portion of the nano double-resistance deep venous catheter provided in this embodiment 3.
Fig. 5 is a schematic structural diagram of a tube portion of the nano double-resistance deep venous catheter provided in this embodiment 4.
Detailed Description
Example 1
Embodiment 1 provides a nano double-resistant deep intravenous catheter, comprising a deep intravenous catheter body 100;
the deep vein catheter body 100 is composed of a deep vein catheter body 110, a deep vein catheter outer slow release layer 120 and a deep vein catheter inner slow release layer 130;
the deep vein catheter main body 100 has a central passage pipe, one end of which has a protection head 101, the other end of which is provided with a branching device 10, and the branching communication of the first branch pipe 11, the second branch pipe 12 and the third branch pipe 13 with the deep vein catheter main body 100 is realized by the branching device 10;
in order to realize the input of different injection medicines, the end of the first branch pipe 11 is provided with an injection terminal 11-1, the end of the second branch pipe 12 is provided with an injection terminal 12-1, the end of the third branch pipe 13 is provided with an injection terminal 13-1, and a valve and the like can be arranged on the third branch pipe for realizing the control of the branch pipe;
the deep vein catheter outer slow release layer 120 is positioned on the outer surface of the deep vein catheter main body 110;
the deep intravenous catheter inner slow release layer 130 is positioned on the inner surface of the deep intravenous catheter main body 110;
as shown in fig. 2, in the present embodiment, the tube body portion is configured such that a deep intravenous catheter inner sustained release layer 130, a deep intravenous catheter main body 110, and a deep intravenous catheter outer sustained release layer 120 are nested in this order from the inside to the outside;
wherein, the deep vein catheter outer slow release layer 120 is filled with a slow release drug with anti-infection and/or anti-thrombus effects, such as: antiphlogistics such as minocycline, rifampin and the like, antithrombotic such as heparin and the like, and the medicines can be mixed according to the conventional dosage proportion and then filled;
the slow release layer 130 in the deep intravenous catheter is filled with a slow release drug with anti-infection and/or anti-thrombosis effects, such as: the medicines can be mixed according to the conventional dosage proportion and then filled.
In addition, the outer visual surface of the deep vein catheter outer slow-release layer is densely provided with nano through holes (the actual size of the through holes is according to the actual size), when the catheter is placed in a vein, due to the compression effect formed by natural expansion of the vein wall, the medicine in the deep vein catheter outer slow-release layer is slowly compressed by the nano through holes, so that a slow-release effect is formed, and meanwhile, after the catheter body is placed in the vein, blood enters and exits the deep vein catheter outer slow-release layer through the nano holes, so that the medicine can be gradually slowly released at an action part in a flushing mode.
Through, in addition, also densely covered on the interior visual surface of this deep vein intraductal slow release layer has nano-scale through-holes, after the pipe is put into the vein, because the injection of medicine and the leading-in of blood produce oppression to the pipe wall, slowly empty the medicine in the deep vein intraductal slow release layer and press out through the nano-hole to form slow release effect, simultaneously, because the body is put into the vein, blood among them passes through the mode that the nano-hole business turn over deep vein intraductal slow release layer can realize gradually passing through the scour with the medicine, is slowly released gradually in the action position and is gone out.
Example 2
Embodiment 2 provides a nano-dual anti-deep intravenous catheter, comprising a deep intravenous catheter body 100;
the deep vein catheter body 100 is composed of a deep vein catheter body 110, a deep vein catheter outer slow release layer 120 and a deep vein catheter inner slow release layer 130;
the deep vein catheter main body 100 has a central passage pipe, one end of which has a protection head 101, the other end of which is provided with a branching device 10, and the branching communication of the first branch pipe 11, the second branch pipe 12 and the third branch pipe 13 with the deep vein catheter main body 100 is realized by the branching device 10;
in order to realize the input of different injection medicines, the end of the first branch pipe 11 is provided with an injection terminal 11-1, the end of the second branch pipe 12 is provided with an injection terminal 12-1, the end of the third branch pipe 13 is provided with an injection terminal 13-1, and a valve and the like can be arranged on the third branch pipe for realizing the control of the branch pipe;
the deep vein catheter outer slow release layer 120 is positioned on the outer surface of the deep vein catheter main body 110;
the deep intravenous catheter inner slow release layer 130 is positioned on the inner surface of the deep intravenous catheter main body 110;
in the present embodiment, the tube body portion is configured such that the deep intravenous catheter inner slow release layer 130 is provided on the inner surface of the deep intravenous catheter main body 110, and the deep intravenous catheter outer slow release layer 120 is provided on the outer surface of the deep intravenous catheter main body 110;
in this embodiment, the problem that the mutual cancellation of the efficacy or the deterioration of the efficacy due to mixed preservation may occur among different drugs is considered.
Thus, in this embodiment, a structure in which different drugs are independently released is proposed on the basis of the above embodiment.
As shown in fig. 3, taking two drugs as examples in the present embodiment, the structure of the outer slow release layer of the deep vein catheter includes a first outer slow release layer 131 of the deep vein catheter and a second outer slow release layer 132 of the deep vein catheter;
the first deep vein catheter outer slow release layer 131 and the second deep vein catheter outer slow release layer 132 are independent from each other and spiral on the outer surface of the deep vein catheter main body 110;
the first deep vein catheter outer slow release layer is filled with one or more of antiphlogistics such as minocycline, rifampicin and the like;
heparin is filled in the second deep intravenous catheter outer slow-release layer.
Also, the outer viewing surfaces of the first deep vein catheter outer slow release layer 131 and the second deep vein catheter outer slow release layer 132 are uniformly distributed with nano holes so as to facilitate exudation of the medicine.
Also, the structure of the slow release layer in the deep vein catheter can be the same as that of the slow release layer outside the deep vein catheter.
Example 3
Embodiment 3 provides a nano-dual anti-deep intravenous catheter, comprising a deep intravenous catheter body 100;
the deep vein catheter body 100 is composed of a deep vein catheter body 110, a deep vein catheter outer slow release layer 120 and a deep vein catheter inner slow release layer 130;
the deep vein catheter main body 100 has a central passage pipe, one end of which has a protection head 101, the other end of which is provided with a branching device 10, and the branching communication of the first branch pipe 11, the second branch pipe 12 and the third branch pipe 13 with the deep vein catheter main body 100 is realized by the branching device 10;
in order to realize the input of different injection medicines, the end of the first branch pipe 11 is provided with an injection terminal 11-1, the end of the second branch pipe 12 is provided with an injection terminal 12-1, the end of the third branch pipe 13 is provided with an injection terminal 13-1, and a valve and the like can be arranged on the third branch pipe for realizing the control of the branch pipe;
the deep vein catheter outer slow release layer 120 is positioned on the outer surface of the deep vein catheter main body 110;
the deep intravenous catheter inner slow release layer 130 is positioned on the inner surface of the deep intravenous catheter main body 110;
in the present embodiment, the tube body portion is configured such that the deep intravenous catheter inner slow release layer 130 is provided on the inner surface of the deep intravenous catheter main body 110, and the deep intravenous catheter outer slow release layer 120 is provided on the outer surface of the deep intravenous catheter main body 110;
in this embodiment, the problem that the mutual cancellation of the efficacy or the deterioration of the efficacy due to mixed preservation may occur among different drugs is considered.
Thus, in this embodiment, a structure in which different drugs are independently released is proposed on the basis of the above embodiment.
As shown in fig. 4, taking two drugs as examples in the present embodiment, the structure of the outer slow release layer of the deep vein catheter includes a first outer slow release layer 131 of the deep vein catheter and a second outer slow release layer 132 of the deep vein catheter;
the first deep vein catheter outer slow release layer 131 and the second deep vein catheter outer slow release layer 132 are independently provided on the outer surface of the deep vein catheter main body 110 in a staggered manner;
the first deep vein catheter outer slow release layer is filled with one or more of antiphlogistics such as minocycline, rifampicin and the like;
heparin is filled in the second deep intravenous catheter outer slow-release layer.
Also, the outer viewing surfaces of the first deep vein catheter outer slow release layer 131 and the second deep vein catheter outer slow release layer 132 are uniformly distributed with nano holes so as to facilitate exudation of the medicine.
Also, the structure of the slow release layer in the deep vein catheter can be the same as that of the slow release layer outside the deep vein catheter.
Example 4
Embodiment 4 provides a nano-dual anti-deep intravenous catheter, comprising a deep intravenous catheter body 100;
the deep vein catheter body 100 is composed of a deep vein catheter body 110, a deep vein catheter outer slow release layer 120 and a deep vein catheter inner slow release layer 130;
the deep vein catheter main body 100 has a central passage pipe, one end of which has a protection head 101, the other end of which is provided with a branching device 10, and the branching communication of the first branch pipe 11, the second branch pipe 12 and the third branch pipe 13 with the deep vein catheter main body 100 is realized by the branching device 10;
in order to realize the input of different injection medicines, the end of the first branch pipe 11 is provided with an injection terminal 11-1, the end of the second branch pipe 12 is provided with an injection terminal 12-1, the end of the third branch pipe 13 is provided with an injection terminal 13-1, and a valve and the like can be arranged on the third branch pipe for realizing the control of the branch pipe;
the deep vein catheter outer slow release layer 120 is positioned on the outer surface of the deep vein catheter main body 110;
the deep intravenous catheter inner slow release layer 130 is positioned on the inner surface of the deep intravenous catheter main body 110;
in the present embodiment, the tube body portion is configured such that the deep intravenous catheter inner slow release layer 130 is provided on the inner surface of the deep intravenous catheter main body 110, and the deep intravenous catheter outer slow release layer 120 is provided on the outer surface of the deep intravenous catheter main body 110;
in this embodiment, a new drug sustained release structure is provided.
As shown in fig. 5, the drug-releasing layer is realized by an outer film layer manufactured by an electrostatic spinning process, and the specific manufacturing method of the outer film layer is as follows: equal amount of polyvinyl alcohol and collagen sugar and rifampicin (the mass ratio of the total concentration of the polymer to the anti-inflammatory agent is 10:0.5-1, and the anti-inflammatory agent or the anti-thrombosis agent can be replaced by other anti-inflammatory agents or the mixture thereof) are dissolved in 6 ml of HFIP, and the mixture is magnetically stirred at normal temperature until the mixture is completely dissolved to obtain the electrostatic spinning solution with the concentration of 5% (g/ml). Placing the obtained electrostatic spinning solution into an injector for electrostatic spinning: the voltage is 12 kv, the syringe advancing speed is 0.8 ml/hr, the receiving distance is 150 mm, the aluminum foil paper is received, the composite nanofiber carrying the anti-inflammatory agent is obtained after vacuum drying, and then the composite nanofiber is covered on the outer surface of the deep vein catheter main body 110 in a scalding manner.
If the double-layer electrostatic spinning effect is required to be achieved, the drug slow-release inner layer is also realized by an inner membrane layer manufactured by an electrostatic spinning process, and the specific manufacturing method of the outer membrane layer comprises the following steps: equivalent polyvinyl alcohol and collagen sugar and heparin (the mass ratio of the total concentration of the polymer to the anti-inflammatory agent is 10:0.5-1, and the anti-inflammatory agent can be replaced by other anti-inflammatory agents or antithrombotic agents or the mixture thereof) are dissolved in 6 ml of HFIP, and the mixture is magnetically stirred at normal temperature until the mixture is completely dissolved to obtain an electrostatic spinning solution with the concentration of 5% (g/ml). Placing the obtained electrostatic spinning solution into an injector for electrostatic spinning: the voltage was 12 kv, the syringe advancing speed was 0.8 ml/hr, the receiving distance was 150 mm, and the aluminum foil paper was received, and the composite nanofiber loaded with the anti-inflammatory agent was obtained after vacuum drying, and then covered on the inner surface of the deep vein catheter main body 110 in a thermoplastic manner.
Claims (5)
1. A nano double-resistance deep venous catheter, which is characterized in that: comprises a deep vein catheter body;
the deep vein catheter body consists of a deep vein catheter main body, a deep vein catheter outer slow-release layer and a deep vein catheter inner slow-release layer;
the deep vein catheter body has a central tube;
the deep vein catheter outer slow release layer is positioned on the outer surface of the deep vein catheter main body;
the slow release layer in the deep intravenous catheter is positioned on the inner surface of the deep intravenous catheter main body;
the slow-release layer outside the deep intravenous catheter is filled with anti-infection and/or antithrombotic drugs;
the slow-release layer in the deep intravenous catheter is filled with anti-infection and/or antithrombotic drugs;
the outer visual surface of the deep vein catheter outer slow release layer is densely provided with nanoscale through holes;
the inner view surface of the slow release layer in the deep vein catheter is also densely provided with nano-scale through holes.
2. A nano-dual anti-deep intravenous catheter according to claim 1, wherein:
the deep vein catheter outer slow-release layer comprises a first deep vein catheter outer slow-release layer and a second deep vein catheter outer slow-release layer;
the first deep vein catheter outer slow release layer and the second deep vein catheter outer slow release layer are arranged on the outer surface of the deep vein catheter main body independently of each other;
different medicines are filled in the first deep vein catheter outer slow release layer and the second deep vein catheter outer slow release layer.
3. A nano-dual anti-deep intravenous catheter according to claim 2, wherein:
the first deep vein catheter outer slow release layer and the second deep vein catheter outer slow release layer are independent from each other and are spirally arranged on the outer surface of the deep vein catheter main body;
or (b)
The first deep vein catheter outer slow release layer and the second deep vein catheter outer slow release layer are independent from each other and are arranged on the outer surface of the deep vein catheter main body in an staggered mode.
4. A nano-dual anti-deep intravenous catheter according to claim 1, wherein:
the slow-release layer in the deep vein catheter comprises a first slow-release layer in the deep vein catheter and a second slow-release layer in the deep vein catheter;
the first deep intravenous catheter inner slow release layer and the second deep intravenous catheter inner slow release layer are arranged on the inner surface of the deep intravenous catheter main body independently of each other;
different medicines are filled in the slow release layer in the first deep vein catheter and the slow release layer in the second deep vein catheter.
5. A nano-dual anti-deep intravenous catheter according to claim 4, wherein:
the first deep intravenous catheter inner slow release layer and the second deep intravenous catheter inner slow release layer are independent from each other and are spirally arranged on the inner surface of the deep intravenous catheter main body;
or (b)
The first deep intravenous catheter inner slow release layer and the second deep intravenous catheter inner slow release layer are independent from each other and are arranged on the inner surface of the deep intravenous catheter main body in an staggered mode.
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| CN202110413656.6A CN113144376B (en) | 2021-04-16 | 2021-04-16 | Nanometer double-resistance deep vein catheter |
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| CN202110413656.6A CN113144376B (en) | 2021-04-16 | 2021-04-16 | Nanometer double-resistance deep vein catheter |
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| CN113144376B true CN113144376B (en) | 2024-03-29 |
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