CN113143805A

CN113143805A - Active composition for improving skin barrier function and preparation method thereof

Info

Publication number: CN113143805A
Application number: CN202110481560.3A
Authority: CN
Inventors: 简婷婷; 朱伟红
Original assignee: Wuxi Jianyuxi Biological Technology Co ltd
Current assignee: Wuxi Jianyuxi Biological Technology Co ltd
Priority date: 2021-03-25
Filing date: 2021-04-30
Publication date: 2021-07-23
Anticipated expiration: 2041-04-30
Also published as: CN113143805B

Abstract

The invention discloses an active composition for improving skin barrier function and a preparation method thereof, wherein the active composition comprises the following components: butanediol, glycerol, 1, 2-hexanediol, squalane, olive oil unsaponifiable matter, shea butter, di-diglycerol polyacyladipate-2, liposomes, cetearyl glucoside, cetearyl alcohol, polyglycerol-10 oleate, polyvinylpyrrolidone, adenosine, magnesium PCA, arnica extract, raspberry ketone, EDTA-disodium, and adding water to 100 parts; the hand cream composition with the function of improving the hand skin barrier aims at the problems of skin dryness, roughness, peeling and the like of the hand skin caused by little sebum secretion or damaged barrier function, moisturizes water and moisture, reduces the moisture loss through skin, moisturizes the skin, and has the effects of softening and resisting oxidation.

Description

Active composition for improving skin barrier function and preparation method thereof

Technical Field

The invention belongs to the technical field of hand cream, and particularly relates to an active composition for improving skin barrier function and a preparation method thereof.

Background

With the improvement of living standard, people pay more attention to the skin care, daily chemical cleaning products used in daily life can cause the damage of sebum on the surface of skin, so that the reduction of sebum on the surface of skin and the excessive secretion of sebaceous glands are caused, the barrier function of the skin is damaged, the skin is dry and loses luster, severe people have rough and rough skin in winter and are easily infected by bacteria, fungi and the like, the hand cream is a skin care product which can heal and smooth skin cracks and is dry and can effectively prevent and treat the rough and dry hand cracks in autumn and winter, however, most of traditional hand cream products only pay attention to water replenishing, the skin is neglected to lock water, the barrier function of the skin is not repaired, many moisturizing components of the hand cream product are difficult to enter the cuticle of the skin, and the skin cannot be moisturized for a long time.

Therefore, how to prepare a hand cream product which has the functions of skin water locking, skin barrier repair and strong skin permeability and can keep moisture for a long time is a technical problem to be solved.

Disclosure of Invention

This section is for the purpose of summarizing some aspects of embodiments of the invention and to briefly introduce some preferred embodiments. In this section, as well as in the abstract and the title of the invention of this application, simplifications or omissions may be made to avoid obscuring the purpose of the section, the abstract and the title, and such simplifications or omissions are not intended to limit the scope of the invention.

The invention provides a hand cream composition for improving skin barrier function, which comprises the following components in part by weight: the composition comprises the following components in parts by mass: 2-8 parts of butanediol, 1-7 parts of glycerol, 0.3-1.5 parts of 1, 2-hexanediol, 4-10 parts of squalane, 1-6 parts of olive (Olea EUROPAEA) oil unsaponifiable matter, 1-6 parts of shea butter, 21-5 parts of di-diglycerol polyacyladipate, 25-50 parts of liposome, 1-5 parts of cetearyl glucoside, 1-5 parts of cetearyl alcohol, 0.2-1 part of polyglycerol-10 oleate, 0.1-0.5 part of polyvinylpyrrolidone, 0.05-0.2 part of adenosine, 0.2-1.5 parts of PCA magnesium, 0.1-0.5 part of Arnica Montana flower extract, 0.2-1 part of raspberry ketone, 0.05-0.1 part of EDTA disodium and water is added to 100 parts;

the liposome comprises the following components in parts by mass: 2-7 parts of hydrogenated lecithin, 31-4 parts of ceramide, 0.5-3 parts of cholesterol, 0.5-3 parts of micromolecule sodium hyaluronate, 0.5-3 parts of hydroxyethyl piperazine ethane sulfonic acid and 100 parts of water.

As a preferred embodiment of the hand cream composition for improving skin barrier function according to the present invention: the hand cream composition consists of the following components: 3-6 parts of butanediol, 2-6 parts of glycerol, 0.5-1 part of 1, 2-hexanediol, 6-9 parts of squalane, 3-4 parts of olive (Olea EUROPAEA) oil unsaponifiable matter, 2-4 parts of shea butter, 22-3 parts of di-diglycerol polyacyladipate, 30-45 parts of liposome, 1.5-3 parts of cetearyl glucoside, 2-4 parts of cetearyl alcohol, 0.4-0.8 part of polyglycerol-10 oleate, 0.1-0.2 part of polyvinylpyrrolidone, 0.1-0.15 part of adenosine, 0.5-1 part of PCA magnesium, 0.2-0.4 part of Arnica Montana flower extract, 0.4-0.7 part of raspberry ketone, 0.05-0.1 part of EDTA disodium and water to 100 parts.

As a preferred embodiment of the hand cream composition for improving skin barrier function according to the present invention: the liposome comprises the following components in parts by mass: 4-6 parts of hydrogenated lecithin, 32-3 parts of ceramide, 2-2.5 parts of cholesterol, 1-2 parts of micromolecular sodium hyaluronate, 1-2 parts of hydroxyethyl piperazine ethane sulfonic acid and 100 parts of water.

As a preferred embodiment of the hand cream composition for improving skin barrier function according to the present invention: the molecular weight of the micromolecular sodium hyaluronate is 3-5 ten thousand.

As another aspect of the present invention, the present invention provides a method for preparing the hand cream composition for improving skin barrier function, comprising: the method comprises the following steps of (1),

(1) adding butanediol, glycerol, 1, 2-hexanediol and polyvinylpyrrolidone into water, mixing, and heating in water bath to 75-85 deg.C;

(2) mixing squalane, olive (Olea EUROPAEA) oil unsaponifiable matter, shea butter, di-diglycerol polyacyladipate-2, cetearyl glucoside, cetearyl alcohol and polyglycerol-10 oleate, adding the mixture obtained in the step (1) into the mixture, and homogenizing at the speed of 2000-4000r/s for 1-4 min;

(3) cooling to 50 deg.C, adding liposome, adenosine, PCA magnesium, Arnica Montana (ARNICA MONTANA) flower extract, and raspberry ketone into the emulsion obtained in step (2), homogenizing at 2000-;

(4) and (4) carrying out gradient homogenization on the emulsion obtained in the step (3) to form nano emulsion.

As a preferred embodiment of the method for preparing a hand cream for improving skin barrier function according to the present invention: the gradient homogenization is carried out for 2-4 times under the pressure of 20-40 MPa; homogenizing at 50-7-Mpa for 2-4 times; homogenizing under 85-95MPa for 2-4 times, each for 0.5-3 min.

As a preferred embodiment of the method for preparing a hand cream for improving skin barrier function according to the present invention: the gradient homogenization is carried out for 3 times under the pressure of 30 MPa; homogenizing at 60MPa for 3 times; homogenizing under 90MPa for 3 times, each for 1 min.

As a preferred embodiment of the method for preparing a hand cream for improving skin barrier function according to the present invention: the preparation method of the liposome comprises dissolving hydrogenated lecithin, ceramide 3 and cholesterol in ethanol, and heating to 75-85 deg.C to obtain oil phase; dissolving micromolecular sodium hyaluronate and hydroxyethyl piperazine ethane sulfonic acid in deionized water, and heating to 75-85 ℃ to be used as a water phase; respectively loading the oil phase and the water phase into a glass injector, connecting the injector with a micro-fluidic chip through a micro-tube, and adjusting the injection flow rate of an injection pump as follows: volume flow rate of water phase channels on two sides of micro-fluidic chip and volume flow rate ratio V of central oil phase channel_{Aqueous phase}/V_{Oil phase}The injection flow rate of the central oil phase channel is set to be 0.2-0.4mg/min, the liposome is collected at the outlet, ethanol is removed by the permeation filtration, and the liposome is sterilized by the filtration of a filter membrane.

The invention has the beneficial effects that: aiming at the problems of dry, rough and peeling of the hand skin caused by little sebum secretion or damaged barrier function, the hand cream composition adopts squalane, shea butter, olive (Olea EUROPAEA) oil unsaponifiable, double-diglycerol polyacyladipate-2 and a skin barrier repair liposome composition containing ceramide 3, cholesterol, hydrogenated lecithin and hydroxyethylpiperazine ethanesulfonic acid, so that on one hand, the bionic sebum replaces the sebum of a hand to moisten the skin, and simultaneously, the synergistic permeation promoting effect of the liposome and the hydroxyethylpiperazine ethanesulfonic acid is utilized to promote the ceramide 3 and the cholesterol to enter the deep layer of the skin, supplement damaged intercellular lipid, repair the barrier function of the hand skin, enhance the skin permeability and the long-acting moisturizing effect, and obviously improve the flexibility and smoothness of the hand skin, Elasticity and barrier function. The raspberry ketone serving as a natural plant component has a good antiseptic effect under the compounding synergistic effect of the raspberry ketone and the 1, 2-hexanediol, and the raspberry ketone moisturizing cream disclosed by the invention has the functions of moisturizing, locking water, reducing percutaneous water loss, moisturizing skin, softening and resisting oxidation.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without inventive exercise. Wherein:

FIG. 1 is a test of the moisture content of the stratum corneum of the skin for each example.

Figure 2 is a skin transdermal water loss value test of various examples.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with examples are described in detail below.

In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be practiced in other ways than those specifically described and will be readily apparent to those of ordinary skill in the art without departing from the spirit of the present invention, and therefore the present invention is not limited to the specific embodiments disclosed below.

Furthermore, reference herein to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one implementation of the invention. The appearances of the phrase "in one embodiment" in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments.

Example 1:

preparing liposome: dissolving 4 parts of hydrogenated lecithin, 2 parts of ceramide 3 and 2 parts of cholesterol in 10 parts of ethanol, and heating to 80 ℃ to obtain an oil phase; dissolving 1 part of micromolecular sodium hyaluronate (molecular weight is 4 ten thousand) and 1 part of hydroxyethyl piperazine ethane sulfonic acid in 80 parts of deionized water, and heating to 80 ℃ to obtain a water phase; respectively loading the oil phase and the water phase into a glass syringe, connecting the syringe with a microfluidic chip through a microtube, and adjusting the injection flow rate of a syringe pump (model WZ-50C2) to be as follows: volume flow rate and central oil phase of water phase channels on two sides of micro-fluidic chipVolumetric flow rate ratio V of the channel_{Aqueous phase}/V_{Oil phase}Setting the injection flow rate of the central oil phase channel to be 0.2mg/min, collecting the liposome at the outlet, filtering to remove ethanol, and filtering to remove bacteria with a 0.22 μm filter membrane, wherein the average particle size of the liposome is 121.3nm, the particle size distribution range is 90-150 nm, and the particle size is uniform and stable.

The hand cream composition formula comprises:

the raw materials are all commercial products.

The preparation method of the hand cream composition comprises the following steps:

(1) adding butanediol, glycerol, 1, 2-hexanediol and polyvinylpyrrolidone into water, mixing, and heating in water bath to 80 deg.C;

(2) mixing squalane, olive (Olea EUROPAEA) oil unsaponifiable matter, shea butter, di-diglycerol polyacyladipate-2, cetearyl glucoside, cetearyl alcohol and polyglycerol-10 oleate, adding into the mixture obtained in the step (1), homogenizing at the speed of 3000r/s for 3 min;

(3) cooling to 50 deg.C, adding liposome, adenosine, PCA magnesium, Arnica Montana (Arnica Montana) flower extract, raspberry ketone, and EDTA disodium into the emulsion obtained in step (2), homogenizing at 3000r/s for 2 min;

(4) carrying out gradient homogenization on the emulsion obtained in the step (3), and homogenizing for 3 times under 30 MPa; homogenizing at 60MPa for 3 times; homogenizing at 90MPa for 3 times, each for 1min to obtain nanoemulsion.

Example 2:

preparing liposome: dissolving 6 parts of hydrogenated lecithin, 3 parts of ceramide and 2 parts of cholesterol in 9 parts of ethanol, and heating to 90 ℃ to obtain an oil phase; 1.5 parts of micromolecular sodium hyaluronate (molecular weight is 4 ten thousand), 1.5 parts of hydroxyethyl piperazine ethane sulfonic acid, and dissolvingDissolving in 80 parts of deionized water, and heating to 90 ℃ to be used as a water phase; loading the oil phase and the water phase into a glass syringe respectively, connecting the syringe with a microfluidic chip through a microtube, and adjusting the injection flow rate of a syringe pump (WZ-50C2) to be as follows: volume flow rate of water phase channels on two sides of micro-fluidic chip and volume flow rate ratio V of central oil phase channel_{Aqueous phase}/V_{Oil phase}The injection flow rate of the central oil phase channel was set at 0.4mg/min, and the liposomes were collected at the outlet, ethanol was removed by diafiltration, and sterilized by filtration through a 0.22 μm filter.

The hand cream composition formula comprises:

example 3:

preparing liposome: dissolving 5 parts of hydrogenated lecithin, 3 parts of ceramide 3 and 2 parts of cholesterol in 10 parts of ethanol, and heating to 80 ℃ to obtain an oil phase; dissolving 2 parts of micromolecular sodium hyaluronate (with the molecular weight of 4 ten thousand) and 2 parts of hydroxyethyl piperazine ethane sulfonic acid in 80 parts of deionized water, and heating to 80 ℃ to be used as a water phase; loading the oil phase and the water phase into a glass syringe respectively, connecting the syringe with a microfluidic chip through a microtube, and adjusting the injection flow rate of a syringe pump (WZ-50C2) to be as follows: volume flow rate of water phase channels on two sides of micro-fluidic chip and volume flow rate ratio V of central oil phase channel_{Aqueous phase}/V_{Oil phase}The injection flow rate of the central oil phase channel was set at 0.3mg/min, and the liposomes were collected at the outlet, ethanol was removed by diafiltration, and sterilized by filtration through a 0.22 μm filter.

The hand cream composition formula comprises:

comparative example 1:

preparing liposome: dissolving 4 parts of hydrogenated lecithin, 2 parts of ceramide 3 and 2 parts of cholesterol in 10 parts of ethanol, and heating to 80 ℃ to obtain an oil phase; 1 part of high molecular sodium hyaluronate (molecular weight 200 ten thousand) is dissolved in 80 parts of deionized water and heated to 80 ℃ to be used as a water phase; loading the oil phase and the water phase into a glass syringe respectively, connecting the syringe with a microfluidic chip through a microtube, and adjusting the injection flow rate of a syringe pump (WZ-50C2) to be as follows: volume flow rate of water phase channels on two sides of micro-fluidic chip and volume flow rate ratio V of central oil phase channel_{Aqueous phase}/V_{Oil phase}The injection flow rate of the central oil phase channel was set at 0.2mg/min, and the liposomes were collected at the outlet, ethanol was removed by diafiltration, and sterilized by filtration through a 0.22 μm filter.

The formulation and preparation method of the hand cream composition are the same as those of example 1.

Comparative example 2:

preparing liposome: dissolving 4 parts of hydrogenated lecithin, 2 parts of ceramide 3 and 2 parts of cholesterol in 10 parts of ethanol, and heating to 80 ℃ to obtain an oil phase; dissolving 1 part of micromolecular sodium hyaluronate (molecular weight is 4 ten thousand) and 1 part of hydroxyethyl piperazine ethane sulfonic acid in 80 parts of deionized water, and heating to 80 ℃ to obtain a water phase; respectively loading the oil phase and the water phase into a glass syringe, connecting the syringe with a microfluidic chip through a microtube, and adjusting the injection flow rate of a syringe pump (model WZ-50C2) to be as follows: volume flow rate of water phase channels on two sides of micro-fluidic chip and volume flow rate ratio V of central oil phase channel_{Aqueous phase}/V_{Oil phase}The injection flow rate of the central oil phase channel was set at 0.1mg/min, and the liposomes were collected at the outlet, ethanol was removed by diafiltration, and sterilized by filtration through a 0.22 μm filter. The average particle size of the liposome is 283.7 nm.

Comparative example 3:

(1) adding butanediol, glycerol, 1, 2-hexanediol, polyvinylpyrrolidone, sodium hyaluronate (molecular weight of 200 ten thousand) and hydroxyethyl piperazine ethane sulfonic acid into water, mixing, and heating in water bath to 80 deg.C;

(2) mixing squalane, olive (Olea EUROPAEA) oil unsaponifiable matter, shea butter, di-diglycerol polyacyladipate-2, cetearyl glucoside, cetearyl alcohol, polyglycerol-10 oleate, hydrogenated lecithin, ceramide 3 and cholesterol, adding into the mixture obtained in the step (1), and homogenizing at 3000r/s for 3 min;

(3) cooling to 50 deg.C, adding PCA magnesium, adenosine, Arnica Montana flower extract, raspberry ketone, and EDTA disodium into the emulsion obtained in step (2), homogenizing at 3000r/s for 2 min;

(4) carrying out gradient homogenization on the emulsion obtained in the step (3), and homogenizing for 3 times under 30 MPa; homogenizing at 60MPa for 3 times; homogenizing at 90MPa for 3 times, each for 1min to obtain nanoemulsion. The amounts of the above-mentioned raw material components added were the same as in example 1.

The hand cream composition formula of each example:

the hand cream compositions of comparative examples 4-6 were prepared in the same manner as in example 1.

Testing moisture content of skin stratum corneum: using a multi-probe skin test system Corneometer to measure the moisture content of the skin of a subject, measuring the moisture content at a selected position for 3 times, and taking the average value; subject 30, women with dry skin in the age range of 20-50 years, test environment: the temperature is 22.0 +/-1.0 ℃; humidity is 50% +/-10%, and the test area is an area 3cm multiplied by 3cm on the inner side of the forearm; during testing, about 2mL of hand cream samples were evenly smeared on the inner side of the arm, and the changes in the moisture content of the stratum corneum before use and 1h and 4h after using different test samples were measured, respectively, and the average moisture content of the stratum corneum of the subjects before use was 29.6 (a.u.).

Testing the percutaneous water loss value: using a Tewameter (coupling)&Khazaka, germany) measured the transdermal water loss value 3 times at selected sites, taking the average; subject 30, women with dry skin in the age range of 20-50 years, test environment: the temperature is 22.0 +/-1.0 ℃; humidity is 50% +/-10%, and the test area is an area 3cm multiplied by 3cm on the inner side of the forearm; during testing, about 2mL of hand cream sample was uniformly applied to the inner side of the arm, and the transdermal water loss values (g/hm) before use and after 1h and 4h of use of different test samples were measured respectively²) The average transdermal water loss value of the tested subject is 13.8g/hm before use²。

The hand cream compositions of example 1 and comparative example 5 were repeatedly placed at-15 ℃ and 45 ℃ for 7 cycles, alternately every 24 hours, and the stability of the hand cream compositions was observed, with "-" indicating no change in the emulsion. "+" indicates emulsion separation.

Stability comparison of example 1 with comparative example 5

Number of weeks	Example 1	Comparative example 5
			0	-	-
1	-	-
			2	-	-
3	-	-
			4	-	-
5	-	-
			6	-	+
7	-	+

Example 1 testing of preservative challenge for hand cream composition:

the results show that the formula in the embodiment 1 can successfully pass the corrosion prevention challenge test, and the corrosion prevention and corrosion prevention of the invention can completely meet the corrosion prevention requirement and has good corrosion prevention effect. The preservative challenge test was performed in the same manner for comparative examples 4 and 6, and the results showed that none of the composition formulations of comparative examples 4 and 6 passed the preservative challenge test. In addition, the invention finds that the single use of 2% of 1, 2-hexanediol as the preservative (no raspberry ketone is added) and fails the preservative challenge test, which indicates that the single use of 2% of 1, 2-hexanediol as the preservative cannot meet the preservative requirement.

The preservative of example 1 was replaced with 0.5% raspberry ketone, 0.5% 1, 2-hexanediol and the preservative challenge test passed, but the values for bacteria, mold yeast were < 10 by day 21.

Chick embryo chorioallantoic membrane test irritation evaluation of several different preservatives:

the stimulation of chick embryo chorioallantoic membrane test shows that: the formula of the hand cream is added with 1% of 1, 2-hexanediol, so that obvious skin irritation can be generated, and meanwhile, researches of the invention find that raspberry ketone has anti-inflammatory and relieving effects, and the raspberry ketone can effectively help to reduce the skin irritation caused by the 1, 2-hexanediol. Therefore, the raspberry ketone which is a natural plant component is added into cosmetics as a preservative, and can play a preservative role and reduce skin irritation.

Aiming at the problems of dry, rough and peeling of the hand skin caused by little sebum secretion or damaged barrier function, the hand cream composition adopts squalane, shea butter, olive (Olea EUROPAEA) oil unsaponifiable, double-diglycerol polyacyladipate-2 and a skin barrier repair liposome composition containing ceramide 3, cholesterol, hydrogenated lecithin and hydroxyethylpiperazine ethanesulfonic acid, so that on one hand, the bionic sebum replaces the sebum of a hand to moisten the skin, and simultaneously, the synergistic permeation promotion effect of the liposome and the hydroxyethylpiperazine ethanesulfonic acid is utilized to promote the ceramide 3 and the cholesterol to enter the deep layer of the skin, supplement damaged intercellular lipid, repair the barrier function of the hand skin, enhance the skin permeability and the long-acting moisturizing effect, and obviously improve the flexibility and smoothness of the hand skin, Elasticity and barrier function. The invention can moisturize water and moisture, simultaneously lock water and moisturize, reduce the moisture loss of the skin, moisturize the skin, and has the effects of softening and moisturizing and resisting oxidation.

According to the invention, the particle size and the distribution range of the liposome directly influence the long-term moisturizing effect of the product, if the liposome is prepared by adopting a traditional thin film hydration method, the prepared liposome has larger and non-uniform particle size, and the moisturizing effect is obviously influenced. The researches of the invention find that the raspberry ketone as a natural plant component has good antiseptic effect under the synergistic effect of compounding with 1, 2-hexanediol, does not generate irritation to skin, and solves the problem of strong skin irritation caused by a chemical antiseptic, and the 1, 2-hexanediol is used as one of water replenishing and moisturizing components and is compounded with the raspberry ketone as the synergistic antiseptic. Meanwhile, a liquid crystal emulsification and thickening system of cetearyl glucoside, cetearyl alcohol, polyglycerol-10 oleate and polyvinylpyrrolidone is preferably selected, the system has high moisturizing and synergistic permeation promoting effects while emulsifying and thickening, the nano-emulsion system prepared by the method is very stable, the product can keep moisture for a long time, and meanwhile, in the preparation process of the product, the nano-emulsion is formed by adopting high-pressure gradient homogenization, so that the emulsion product is uniform in particle size and stable and long-acting.

It should be noted that the above-mentioned embodiments are only for illustrating the technical solutions of the present invention and not for limiting, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions may be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, which should be covered by the claims of the present invention.

Claims

1. A hand cream composition for improving skin barrier function, characterized by: the composition comprises the following components in parts by mass: 2-8 parts of butanediol, 1-7 parts of glycerol, 0.3-1.5 parts of 1, 2-hexanediol, 4-10 parts of squalane, 1-6 parts of olive (Olea EUROPAEA) oil unsaponifiable matter, 1-6 parts of shea butter, 21-5 parts of di-diglycerol polyacyladipate, 25-50 parts of liposome, 1-5 parts of cetearyl glucoside, 1-5 parts of cetearyl alcohol, 0.2-1 part of polyglycerol-10 oleate, 0.1-0.5 part of polyvinylpyrrolidone, 0.05-0.2 part of adenosine, 0.2-1.5 parts of PCA magnesium, 0.1-0.5 part of Arnica Montana flower extract, 0.2-1 part of raspberry ketone, 0.05-0.1 part of EDTA disodium and water is added to 100 parts;

2. The hand cream composition for improving skin barrier function according to claim 1, characterized in that: the hand cream composition consists of the following components: 3-6 parts of butanediol, 2-6 parts of glycerol, 0.5-1 part of 1, 2-hexanediol, 6-9 parts of squalane, 3-4 parts of olive (Olea EUROPAEA) oil unsaponifiable matter, 2-4 parts of shea butter, 22-3 parts of di-diglycerol polyacyladipate, 30-45 parts of liposome, 1.5-3 parts of cetearyl glucoside, 2-4 parts of cetearyl alcohol, 0.4-0.8 part of polyglycerol-10 oleate, 0.1-0.2 part of polyvinylpyrrolidone, 0.1-0.15 part of adenosine, 0.5-1 part of PCA magnesium, 0.2-0.3 part of Arnica Montana flower extract, 0.4-0.7 part of raspberry ketone, 0.05-0.1 part of EDTA disodium and water to 100 parts.

3. The hand cream composition for improving skin barrier function according to claim 1, characterized in that: the liposome comprises the following components in parts by mass: 4-6 parts of hydrogenated lecithin, 32-3 parts of ceramide, 2-2.5 parts of cholesterol, 1-2 parts of micromolecular sodium hyaluronate, 1-2 parts of hydroxyethyl piperazine ethane sulfonic acid and 100 parts of water.

4. A hand cream composition for improving skin barrier function according to any one of claims 1 to 3, characterized in that: the molecular weight of the micromolecular sodium hyaluronate is 3-5 ten thousand.

5. A method of preparing the hand cream composition for improving skin barrier function according to claim 1, characterized in that: the method comprises the following steps of (1),

6. The method for preparing a hand cream composition for improving skin barrier function according to claim 5, characterized in that: the gradient homogenization is carried out for 2-4 times under the pressure of 20-40 MPa; homogenizing at 50-7-Mpa for 2-4 times; homogenizing under 85-95MPa for 2-4 times, each for 0.5-3 min.

7. The method for preparing a hand cream composition for improving skin barrier function according to claim 6, characterized in that: the gradient homogenization is carried out for 3 times under the pressure of 30 MPa; homogenizing at 60MPa for 3 times; homogenizing under 90MPa for 3 times, each for 1 min.

8. The method for preparing a hand cream composition for improving skin barrier function according to claim 5, characterized in that: the preparation method of the liposome comprises dissolving hydrogenated lecithin, ceramide 3 and cholesterol in ethanol, and heating to 75-85 deg.C to obtain oil phase; dissolving micromolecular sodium hyaluronate and hydroxyethyl piperazine ethane sulfonic acid in deionized water, and heating to 75-85 ℃ to be used as a water phase; respectively loading the oil phase and the water phase into a glass injector, connecting the injector with a micro-fluidic chip through a micro-tube, and adjusting the injection flow rate of an injection pump as follows: volume flow rate of water phase channels on two sides of micro-fluidic chip and volume flow rate ratio V of central oil phase channel_{Aqueous phase}/V_{Oil phase}The injection flow rate of the central oil phase channel is set to be 0.2-0.4mg/min, the liposome is collected at the outlet, ethanol is removed by the permeation filtration, and the liposome is sterilized by the filtration of a filter membrane.