CN113116296A - Photoacoustic and ultrasonic collaborative diagnosis and treatment system - Google Patents
Photoacoustic and ultrasonic collaborative diagnosis and treatment system Download PDFInfo
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Abstract
The invention discloses a photoacoustic ultrasonic collaborative diagnosis and treatment system, which comprises: a photoacoustic monitoring device, an ultrasound physiotherapy device, and a controller; the photoacoustic monitoring device is used for sending a laser signal to a target sample and sending a trigger signal to the controller while sending the laser signal to the target sample; the ultrasonic physiotherapy equipment comprises an ultrasonic physiotherapy probe, a controller and a control module, wherein the ultrasonic physiotherapy probe is used for sending an ultrasonic excitation signal to a target sample according to an excitation mode parameter pre-stored by the controller; the controller is configured to receive a trigger signal sent by the photoacoustic monitoring apparatus, pre-store excitation mode parameters of the ultrasound physiotherapy apparatus, receive a photoacoustic signal and an ultrasound echo signal, and analyze the photoacoustic signal and the ultrasound echo signal, where the photoacoustic signal is excited by a target sample by the laser signal, and the ultrasound echo signal is generated by the ultrasound excitation signal by the target sample. The invention improves the use safety and avoids secondary damage to the damaged tissue.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a photoacoustic and ultrasonic collaborative diagnosis and treatment system.
Background
Medically, a medical system is generally used to repair and heal damaged tissues of a diseased part of a human body. The most common diagnosis and treatment system is a low-intensity ultrasonic diagnosis and treatment system, which acts ultrasonic waves with certain energy on a pathological change part of a human body to generate biophysical effects such as a pyrogenicity effect, a mechanical oscillation effect, a sound rush current effect and the like, accelerates the synthesis and release of angiogenesis factors and related proteins, changes the permeability of cell membranes, accelerates the movement of leukocytes, plays an anti-inflammatory role, accelerates the synthesis and maturation of collagen, improves blood circulation and blood flow, promotes blood oxygen metabolism, further achieves the effects of cleaning, activating and repairing damaged cell tissues, and further promotes the repair and healing of the damaged tissues.
However, the diagnosis and treatment system often causes secondary damage to the damaged tissues, and the use safety is low.
Disclosure of Invention
The embodiment of the invention provides a photoacoustic ultrasonic collaborative diagnosis and treatment system, which is used for repairing and healing damaged tissues of human lesion parts, improving the use safety and avoiding secondary damage to the damaged tissues, and comprises: a photoacoustic monitoring device, an ultrasound physiotherapy device, and a controller;
the photoacoustic monitoring device is used for sending a laser signal to a target sample and sending a trigger signal to the controller while sending the laser signal to the target sample;
the ultrasonic physiotherapy equipment comprises an ultrasonic physiotherapy probe, a controller and a control module, wherein the ultrasonic physiotherapy probe is used for sending an ultrasonic excitation signal to a target sample according to an excitation mode parameter pre-stored by the controller;
the controller is configured to receive a trigger signal sent by the photoacoustic monitoring apparatus, pre-store excitation mode parameters of the ultrasound physiotherapy apparatus, receive a photoacoustic signal and an ultrasound echo signal, and analyze the photoacoustic signal and the ultrasound echo signal, where the photoacoustic signal is excited by a target sample by the laser signal, and the ultrasound echo signal is generated by the ultrasound excitation signal by the target sample.
Compared with the scheme of repairing and healing the damaged tissues of the pathological part of the human body by using a low-intensity ultrasonic physiotherapy system in the prior art, the photoacoustic and ultrasonic collaborative diagnosis and treatment system provided by the embodiment of the invention comprises the following components: a photoacoustic monitoring device, an ultrasound physiotherapy device, and a controller; the photoacoustic monitoring device is used for sending a laser signal to a target sample and sending a trigger signal to the controller while sending the laser signal to the target sample; the ultrasonic physiotherapy equipment comprises an ultrasonic physiotherapy probe, a controller and a control module, wherein the ultrasonic physiotherapy probe is used for sending an ultrasonic excitation signal to a target sample according to an excitation mode parameter pre-stored by the controller; the controller is configured to receive a trigger signal sent by the photoacoustic monitoring apparatus, pre-store excitation mode parameters of the ultrasound physiotherapy apparatus, receive a photoacoustic signal and an ultrasound echo signal, and analyze the photoacoustic signal and the ultrasound echo signal, where the photoacoustic signal is excited by a target sample by the laser signal, and the ultrasound echo signal is generated by the ultrasound excitation signal by the target sample. The photoacoustic ultrasonic collaborative diagnosis and treatment system provided by the embodiment of the invention is additionally provided with the photoacoustic monitoring device on the basis of the ultrasonic physical therapy device, the photoacoustic monitoring device is used for sending the laser signal to the target sample, and the controller is used for analyzing the photoacoustic signal of the laser signal excited by the target sample, so that the working state of the ultrasonic physical therapy system is effectively monitored, the use safety is improved, and the secondary damage to the damaged tissue is avoided.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts. In the drawings:
FIG. 1 is a structural diagram of a photoacoustic ultrasound collaborative diagnosis system according to an embodiment of the present invention;
FIG. 2 is a block diagram of a photoacoustic monitoring apparatus in an embodiment of the present invention;
FIG. 3 is a structural diagram of an ultrasonic physiotherapy apparatus in an embodiment of the present invention;
fig. 4 is a diagram of a controller structure in an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the embodiments of the present invention are further described in detail below with reference to the accompanying drawings. The exemplary embodiments and descriptions of the present invention are provided to explain the present invention, but not to limit the present invention.
In order to repair and heal damaged tissues of a diseased part of a human body, improve use safety, and avoid secondary damage to tissues to be repaired, an embodiment of the present invention provides a photoacoustic ultrasound collaborative diagnosis and treatment system, which may include: a photoacoustic monitoring apparatus 100, an ultrasound therapy apparatus 200, and a controller 300;
the photoacoustic monitoring apparatus 100 is configured to transmit a laser signal to a target sample, and transmit a trigger signal to the controller 300 while transmitting the laser signal to the target sample;
the ultrasonic physiotherapy apparatus 200 includes an ultrasonic physiotherapy probe for transmitting an ultrasonic excitation signal to a target sample according to an excitation pattern parameter pre-stored in the controller 300;
the controller 300 is configured to receive a trigger signal transmitted by the photoacoustic monitoring apparatus 100, pre-store excitation mode parameters of the ultrasound therapy apparatus 200, receive a photoacoustic signal and an ultrasound echo signal, and analyze the photoacoustic signal and the ultrasound echo signal, wherein the photoacoustic signal is excited by the laser signal through the target sample, and the ultrasound echo signal is generated by the ultrasound excitation signal through the target sample.
As shown in fig. 1, the photoacoustic ultrasound collaborative diagnosis and treatment system provided by the embodiment of the present invention includes: a photoacoustic monitoring apparatus 100, an ultrasound therapy apparatus 200, and a controller 300; the photoacoustic monitoring apparatus 100 is configured to transmit a laser signal to a target sample, and transmit a trigger signal to the controller 300 while transmitting the laser signal to the target sample; the ultrasonic physiotherapy apparatus 200 includes an ultrasonic physiotherapy probe for transmitting an ultrasonic excitation signal to a target sample according to an excitation pattern parameter pre-stored in the controller 300; the controller 300 is configured to receive a trigger signal transmitted by the photoacoustic monitoring apparatus 100, pre-store excitation mode parameters of the ultrasound therapy apparatus 200, receive a photoacoustic signal and an ultrasound echo signal, and analyze the photoacoustic signal and the ultrasound echo signal, wherein the photoacoustic signal is excited by the laser signal through the target sample, and the ultrasound echo signal is generated by the ultrasound excitation signal through the target sample. The photoacoustic ultrasonic collaborative diagnosis and treatment system provided by the embodiment of the invention is additionally provided with the photoacoustic monitoring device 100 on the basis of the ultrasonic physiotherapy device 200, the photoacoustic monitoring device 100 is utilized to send laser signals to a target sample, and the controller 300 is utilized to analyze the photoacoustic signals of the laser signals excited by the target sample, so that the working state of the ultrasonic physiotherapy system is effectively monitored, the use safety is improved, and secondary damage to damaged tissues is avoided.
As mentioned above, the low-intensity ultrasonic therapy system is generally used in medicine to repair and heal the damaged tissue of the diseased part of the human body, however, the therapy system often causes secondary damage to the damaged tissue and has low safety. The inventor finds that the photoacoustic monitoring has the high contrast characteristic of optical imaging and the deep penetration characteristic of ultrasonic imaging, can perform nondestructive, non-invasive and continuous dynamic monitoring on the injury healing process, can obtain morphological images of regeneration and repair of superficial and deep tissues, can monitor functional metabolic information reflected by the blood oxygen saturation, and can monitor the temperature change of the deep tissues. Therefore, the photoacoustic ultrasonic collaborative diagnosis and treatment system provided by the embodiment of the invention is additionally provided with the photoacoustic monitoring device 100 on the basis of the ultrasonic physiotherapy device, the photoacoustic monitoring device 100 is used for sending the laser signal to the target sample, and the controller 300 is used for analyzing the photoacoustic signal of the laser signal excited by the target sample, so that the working state of the ultrasonic physiotherapy system is effectively monitored, the use safety is improved, and secondary damage to the damaged tissue is avoided.
In an embodiment, as shown in fig. 2, the photoacoustic monitoring apparatus 100 includes: a laser group 101 for emitting laser light according to a preset laser parameter; and the spatial light path shaping and optical fiber light path conducting equipment 102 is used for preprocessing the light path formed by the laser, coupling the processed light path into a one-to-two multimode optical fiber bundle, and transmitting a laser signal to a target sample after the light path is conducted by the one-to-two multimode optical fiber bundle.
In this embodiment, the target sample may be deep or superficial vascular injury tissue, such as atherosclerosis, venous thrombosis, deep penetrating injury, etc. Those skilled in the art can understand that the photoacoustic and ultrasonic collaborative diagnosis and treatment system provided by the embodiment of the present invention is an exemplary illustration for diagnosing and treating a damaged vascular tissue, and other damaged vascular tissues can be diagnosed and treated according to requirements during implementation, and related modifications all fall within the scope of the present invention.
In this embodiment, the laser group 101 may be a multi-wavelength laser group. Four lasers with the same performance index are set into a laser group 101, the laser emission sequence among the lasers is coordinated through a delay circuit, and the laser group has the characteristics of low hardware cost and controllable delay.
In this embodiment, the laser group 101 emits laser light according to preset laser parameters, where the laser parameters include: a pulse width parameter, a pulse peak energy parameter, and a repetition frequency parameter. The following rules are required when the laser parameters are preset:
pulse width parameters: the set pulse width must satisfy the requirement of exciting the photoacoustic signal, generally is ns pulse width, and cannot excite the photoacoustic signal if ms pulse width or mum pulse width;
pulse peak energy parameter: the set pulse peak energy should ensure that the signal intensity of the pulse signal does not exceed the maximum value which can be received by the data acquisition card and cannot be infinite;
repetition frequency parameters: the set repetition frequency depends on the imaging real-time requirements and can be set to 10 Hz.
In this embodiment, the spatial light path shaping and fiber light path conducting device 102 is configured to pre-process a light path formed by the laser, couple the processed light path into a one-to-two multimode fiber bundle, and send a laser signal to a target sample after the light path is conducted by the one-to-two multimode fiber bundle. Wherein the pretreatment comprises: the method comprises the steps of lens group collimation processing, facula beam-shrinking processing and light energy attenuation processing. The pretreated light path is coupled into a one-to-two multimode fiber bundle positioned in the fiber coupler, and a laser signal is transmitted to a target sample after being conducted by the fiber bundle to irradiate the surface of the target sample, so that the laser forms uniform circular spots at the inlet end of the fiber, and the coupling efficiency of the fiber is improved.
In this embodiment, the spatial light path shaping and fiber light path guiding device 102 may include: the laser device comprises a diaphragm, a steering mirror, a convex lens and an attenuation sheet, wherein the diaphragm is connected with a laser group 101 and is used for reducing laser beams; the steering mirror and the convex lens are connected with the laser group 101 and are used for shaping, gathering, beam-shrinking and collimating laser beams; the attenuation sheet is used for rotating the controllable attenuation rate so as to finely adjust the light energy. The diaphragm, the steering mirror, the convex lens and the attenuation sheet can be set by a technician according to needs.
In an embodiment, the ultrasound therapy apparatus 200 comprises an ultrasound therapy probe 201 for transmitting an ultrasound excitation signal to the target specimen according to an excitation pattern parameter pre-stored by the controller 300.
In this embodiment, the ultrasonic excitation signal includes: an ultrasonic imaging excitation signal and an ultrasonic physiotherapy excitation signal; wherein the ultrasonic echo signal is generated by the ultrasonic excitation signal via a target sample comprising: wherein the ultrasound echo signal is generated by the ultrasound imaging excitation signal via a target sample.
In this embodiment, as shown in fig. 3, the ultrasound therapy apparatus 200 further includes: the power amplifier 202 is used for amplifying the power of the ultrasonic physiotherapy probe 201, and the impedance matching module 203 is used for performing impedance matching processing on the ultrasonic physiotherapy probe 201. The impedance matching is a conventional mode of ultrasonic probe performance characterization, the impedance test of each array element of an ultrasonic array is required to be carried out, an impedance analyzer can be adopted, and then according to the tested resistance, inductance and capacitance values, the compensation is carried out externally according to the principle of a resonant circuit, the inductance and the capacitance are offset, so that the array elements are equivalent to a pure resistance.
In this embodiment, the ultrasonic physiotherapy probe 201 adopts a concave ultrasonic array. The inventor finds that the existing ultrasonic physiotherapy equipment adopts a single probe, has the defects that space dynamic focusing cannot be carried out, an external mechanical moving mode can only be adopted, time and labor are wasted, accurate positioning cannot be achieved, control parameters are few, and only a power adjusting mode can be provided. The temperature of ultrasonic physiotherapy is difficult to control, and the tissue is easy to be damaged. Therefore, the concave ultrasonic array adopted by the invention can be a concave low-intensity ultrasonic array, and can control parameters of a plurality of excitation modes, so that better control of ultrasonic physical therapy effects such as micro-flow dispersion, mechanical friction and the like is realized, the scanning range of the ultrasonic array is large, dynamic focusing can be realized, and the temperature of the ultrasonic physical therapy can be monitored by combining temperature data obtained according to the photoacoustic signal. Excitation mode parameters include: transmitting one or any combination of a coding type parameter, a spatial dynamic focusing radiation region parameter, an ultrasonic excitation sound intensity parameter, an ultrasonic excitation frequency parameter and an ultrasonic excitation action period parameter; the power amplifier 202 is further configured to perform power amplification processing on the excitation mode parameter. The transmission coding type parameters are used for controlling the mechanical micro-friction and micro-flow dispersion of the ultrasonic physical therapy and the ultrasonic physical therapy effects such as ultrasonic cavitation and the like; the parameters of the space dynamic focusing radiation area are used for space positioning, and the positioning precision is higher; the ultrasonic excitation sound intensity parameter, the ultrasonic excitation frequency parameter and the ultrasonic excitation action period parameter are used for controlling the thermal effect of the ultrasonic physical therapy. It should be noted that ultrasound therapy is the result of a variety of physical effects, including mechanical micro-friction, micro-flow dispersion, ultrasonic cavitation and thermal effects, and therefore, different excitation mode parameters are required to control the different effects.
In an embodiment, the controller 300 is configured to receive a trigger signal transmitted by the photoacoustic monitoring apparatus 100, store excitation mode parameters of the ultrasound therapy apparatus 200 in advance, receive a photoacoustic signal and an ultrasound echo signal, and analyze the photoacoustic signal and the ultrasound echo signal, wherein the photoacoustic signal is excited by the laser signal through the target sample, and the ultrasound echo signal is generated by the ultrasound excitation signal through the target sample.
In this embodiment, as shown in fig. 4, the controller 300 includes: a sequential logic controller 301, a memory 302, a signal acquisition device 303 and an analysis processor 304; the sequential logic controller 301 is configured to receive a trigger signal sent by the photoacoustic monitoring device 100, and perform sequential logic control on the photoacoustic and ultrasonic collaborative diagnosis and treatment system according to the trigger signal; the memory 302 is used for storing the excitation mode parameters of the ultrasonic physiotherapy device 200 in advance; the signal acquisition device 303 is configured to acquire a photoacoustic signal and an ultrasonic echo signal; the analysis processor 304 is configured to analyze the photoacoustic signal and the ultrasonic echo signal. The sequential logic controller 301 receives a trigger signal sent by the photoacoustic monitoring device 100, and according to the sequential logic between the devices in the photoacoustic ultrasound collaborative diagnosis and treatment system in cooperation with the trigger signal, the controller 300 notifies the ultrasound physiotherapy device 200 to receive or collect photoacoustic signals and ultrasound echo signals after receiving the trigger signal, so that the situation that the signals cannot be received in time is avoided. The time sequence logic of the photoacoustic ultrasonic collaborative diagnosis and treatment system can be as follows: sending a trigger signal-receiving a photoacoustic signal-sending an ultrasonic imaging excitation signal-receiving an ultrasonic echo signal-sending an ultrasonic physiotherapy excitation signal-sending a next trigger signal-receiving a photoacoustic signal-sending an ultrasonic imaging excitation signal-receiving an ultrasonic echo signal-sending an ultrasonic physiotherapy excitation signal, and so on, wherein the hardware connection can be made through a signal line.
In this embodiment, the signal acquisition device 303 is further configured to perform signal amplification processing, filtering processing, and discrete processing on the acquired photoacoustic signal and the acquired ultrasound echo signal; the analysis processor 304 is further configured to analyze the photoacoustic signal and the ultrasonic echo signal after the signal amplification processing, the filtering processing, and the discrete processing.
In this embodiment, the analysis processor 304 is configured to image the photoacoustic signal and the ultrasound echo signal. The inventors have found that photoacoustic signals can be used not only for structural imaging, but also for functional imaging, reflecting the blood oxygenation information of tissue by multi-wavelength scanning. In addition, the photoacoustic signal may also perform temperature measurement of the damaged tissue, measuring the temperature for the ultrasound therapy apparatus 200. The imaging can intuitively reflect the structure, function and temperature information of the physical therapy part in an image mode.
In this embodiment, the processor stores and analyzes the photoacoustic signal and the ultrasonic echo signal, and cooperates with each device in the photoacoustic and ultrasonic collaborative diagnosis and treatment system to achieve collaborative diagnosis and treatment of a target sample. The photoacoustic and ultrasonic collaborative diagnosis and treatment system also comprises a motion control device which is used for three-dimensionally moving the phantom target, so that the range of ultrasonic physical therapy and photoacoustic imaging is wider.
In this embodiment, the analysis processor 304 is configured to control the excitation mode parameter, and reconstruct the photoacoustic signal and the ultrasonic echo signal. The reconstruction may employ back-projection reconstruction methods known in the art.
In an embodiment, the photoacoustic ultrasonic collaborative diagnosis and treatment system provided by the embodiment of the invention utilizes photoacoustic signal imaging to construct a structural and functional multi-parameter monitoring and tissue temperature measuring model in deep tissues, wherein the photoacoustic imaging is formed by a photoacoustic signal through a reconstruction method, and parameters required by the photoacoustic imaging depend on geometric positions of an ultrasonic imaging probe and a region to be imaged. And imaging by using the ultrasonic echo signals, displaying and identifying the damage section structure, co-registering with the photoacoustic image, and integrating the photoacoustic signals and the ultrasonic anatomical information to form a bimodal imaging system. The photoacoustic signal imaging and the ultrasonic echo signal imaging can share hardware, and can image the same target sample, except that the ultrasonic echo signal reflects acoustic impedance information of tissues, and the photoacoustic signal reflects optical absorption information. Different physical information is reflected by the same target sample, so that the acoustic impedance and the light absorption information can be subjected to image registration to form dual-mode imaging. The image registration method can be a depth registration method, and the photoacoustic image and the ultrasound are overlaid in the depth direction.
In the embodiment, the photoacoustic ultrasonic collaborative diagnosis and treatment system provided by the embodiment of the invention takes an ultrasonic echo signal image as a background, performs perspective and imaging target automatic identification processing on the photoacoustic signal image, and performs geometric superposition in the transverse direction and the depth direction of an ultrasonic array according to the ultrasonic echo signal image and the imaging target automatic identification processing, so that image fusion of two modes of ultrasonic echo signal imaging and photoacoustic signal imaging is realized, and quantitative monitoring of functional parameters such as blood oxygen saturation, tissue temperature and the like is performed at the same time. The ultrasonic array probe is adopted, and the deflection and the spatial focusing of the sound beam are realized by controlling the delay time of the probe, so that the accurate and rapid treatment of the injury position is realized. The key of the dynamic focusing lies in effective and accurate control of time and space for transmitting the acoustic beam, especially the important factor of time delay precision which influences the dynamic focusing of the acoustic beam, the depth of a focal zone of an acoustic focus is improved, the width of the focus is reduced, and therefore effective ultrasonic radiation within a certain depth range is achieved.
In summary, the photoacoustic and ultrasonic collaborative diagnosis and treatment system provided by the embodiment of the present invention includes: a photoacoustic monitoring device, an ultrasound physiotherapy device, and a controller; the photoacoustic monitoring device is used for sending a laser signal to a target sample and sending a trigger signal to the controller while sending the laser signal to the target sample; the ultrasonic physiotherapy equipment comprises an ultrasonic physiotherapy probe, a controller and a control module, wherein the ultrasonic physiotherapy probe is used for sending an ultrasonic excitation signal to a target sample according to an excitation mode parameter pre-stored by the controller; the controller is configured to receive a trigger signal sent by the photoacoustic monitoring apparatus, pre-store excitation mode parameters of the ultrasound physiotherapy apparatus, receive a photoacoustic signal and an ultrasound echo signal, where the photoacoustic signal is excited by the laser signal through a target sample, and the ultrasound echo signal is generated by the ultrasound excitation signal through the target sample, and analyze the photoacoustic signal and the ultrasound echo signal. The photoacoustic ultrasonic collaborative diagnosis and treatment system provided by the embodiment of the invention is additionally provided with the photoacoustic monitoring device on the basis of the ultrasonic physical therapy device, the photoacoustic monitoring device is used for sending the laser signal to the target sample, and the controller is used for analyzing the photoacoustic signal of the laser signal excited by the target sample, so that the working state of the ultrasonic physical therapy system is effectively monitored, the use safety is improved, and the secondary damage to the damaged tissue is avoided.
As will be appreciated by one skilled in the art, embodiments of the present invention may be provided as a method, system, or computer program product. Accordingly, the present invention may take the form of an entirely hardware embodiment, an entirely software embodiment or an embodiment combining software and hardware aspects. Furthermore, the present invention may take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROM, optical storage, and the like) having computer-usable program code embodied therein.
The present invention is described with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems), and computer program products according to embodiments of the invention. It will be understood that each flow and/or block of the flow diagrams and/or block diagrams, and combinations of flows and/or blocks in the flow diagrams and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, embedded processor, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.
These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including instruction means which implement the function specified in the flowchart flow or flows and/or block diagram block or blocks.
These computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are only exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. A photoacoustic ultrasound collaborative diagnosis and treatment system, comprising: a photoacoustic monitoring device, an ultrasound physiotherapy device, and a controller;
the photoacoustic monitoring device is used for sending a laser signal to a target sample and sending a trigger signal to the controller while sending the laser signal to the target sample;
the ultrasonic physiotherapy equipment comprises an ultrasonic physiotherapy probe, a controller and a control module, wherein the ultrasonic physiotherapy probe is used for sending an ultrasonic excitation signal to a target sample according to an excitation mode parameter pre-stored by the controller;
the controller is configured to receive a trigger signal sent by the photoacoustic monitoring apparatus, pre-store excitation mode parameters of the ultrasound physiotherapy apparatus, receive a photoacoustic signal and an ultrasound echo signal, and analyze the photoacoustic signal and the ultrasound echo signal, where the photoacoustic signal is excited by a target sample by the laser signal, and the ultrasound echo signal is generated by the ultrasound excitation signal by the target sample.
2. The photoacoustic ultrasound collaborative clinical system of claim 1 wherein the photoacoustic monitoring device comprises:
the laser group is used for emitting laser according to preset laser parameters;
and the space light path shaping and optical fiber light path conducting equipment is used for preprocessing the light path formed by the laser, coupling the processed light path into a one-to-two multimode optical fiber bundle, and transmitting a laser signal to a target sample after the light path is conducted by the one-to-two multimode optical fiber bundle.
3. The photoacoustic ultrasound collaborative clinical system of claim 2 wherein the laser parameters comprise: a pulse width parameter, a pulse peak energy parameter, and a repetition frequency parameter.
4. The photoacoustic ultrasound collaborative clinical system of claim 1 wherein the ultrasound therapy device further comprises: the power amplifier and the impedance matching module are used for carrying out power amplification and impedance matching processing on the ultrasonic physiotherapy probe.
5. The photoacoustic ultrasound collaborative diagnosis and treatment system according to claim 4, wherein the ultrasound therapy probe employs a concave ultrasound array.
6. The photoacoustic ultrasound collaborative clinical system of claim 5 wherein the excitation mode parameters comprise: transmitting one or any combination of a coding type parameter, a spatial dynamic focusing radiation region parameter, an ultrasonic excitation sound intensity parameter, an ultrasonic excitation frequency parameter and an ultrasonic excitation action period parameter;
the power amplifier is also used for carrying out power amplification processing on the excitation mode parameters.
7. The photoacoustic ultrasound collaborative clinical system of claim 1 wherein the ultrasound excitation signal comprises: an ultrasonic imaging excitation signal and an ultrasonic physiotherapy excitation signal;
the ultrasonic echo signal generated by the ultrasonic excitation signal via a target sample comprises: the ultrasound echo signal is generated by the ultrasound imaging excitation signal via a target sample.
8. The photoacoustic ultrasound collaborative clinical system of claim 1 wherein the controller comprises: the system comprises a sequential logic controller, a memory, a signal acquisition device and an analysis processor;
the sequential logic controller is used for receiving a trigger signal sent by the photoacoustic monitoring equipment and performing sequential logic control on the photoacoustic and ultrasonic collaborative diagnosis and treatment system according to the trigger signal;
the memory is used for pre-storing the excitation mode parameters of the ultrasonic physiotherapy equipment;
the signal acquisition equipment is used for acquiring photoacoustic signals and ultrasonic echo signals;
the analysis processor is used for analyzing the photoacoustic signal and the ultrasonic echo signal.
9. The photoacoustic ultrasound collaborative clinical system of claim 8 wherein the analysis processor is further configured to image photoacoustic signals and ultrasound echo signals.
10. The photoacoustic ultrasound collaborative diagnosis and treatment system according to claim 8 wherein the signal acquisition device is further configured to perform signal amplification processing, filtering processing and discrete processing on the acquired photoacoustic signal and ultrasound echo signal;
the analysis processor is further used for analyzing the photoacoustic signal and the ultrasonic echo signal after signal amplification processing, filtering processing and discrete processing.
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