CN113102473B - Overdue medicine harmless treatment method - Google Patents
Overdue medicine harmless treatment method Download PDFInfo
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- CN113102473B CN113102473B CN202110493382.6A CN202110493382A CN113102473B CN 113102473 B CN113102473 B CN 113102473B CN 202110493382 A CN202110493382 A CN 202110493382A CN 113102473 B CN113102473 B CN 113102473B
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- overdue
- stainless steel
- tank body
- oyster shells
- drugs
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims abstract description 16
- 229940079593 drug Drugs 0.000 claims abstract description 33
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 19
- 241000237502 Ostreidae Species 0.000 claims abstract description 19
- 235000020636 oyster Nutrition 0.000 claims abstract description 19
- 239000002699 waste material Substances 0.000 claims abstract description 17
- 229910001220 stainless steel Inorganic materials 0.000 claims abstract description 15
- 239000010935 stainless steel Substances 0.000 claims abstract description 15
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 238000000227 grinding Methods 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims description 15
- 239000011148 porous material Substances 0.000 claims description 4
- 238000007873 sieving Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 2
- 235000013372 meat Nutrition 0.000 claims description 2
- 229940126589 solid medicine Drugs 0.000 claims description 2
- 230000007613 environmental effect Effects 0.000 abstract description 6
- 230000015556 catabolic process Effects 0.000 abstract description 5
- 238000006731 degradation reaction Methods 0.000 abstract description 5
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract description 2
- 238000001179 sorption measurement Methods 0.000 abstract description 2
- 238000000498 ball milling Methods 0.000 description 17
- 230000000694 effects Effects 0.000 description 10
- 230000012010 growth Effects 0.000 description 9
- 239000004480 active ingredient Substances 0.000 description 5
- 238000002386 leaching Methods 0.000 description 5
- 239000002957 persistent organic pollutant Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229910000831 Steel Inorganic materials 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 230000000593 degrading effect Effects 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000001784 detoxification Methods 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000012137 tryptone Substances 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- UUTKICFRNVKFRG-WDSKDSINSA-N (4R)-3-[oxo-[(2S)-5-oxo-2-pyrrolidinyl]methyl]-4-thiazolidinecarboxylic acid Chemical compound OC(=O)[C@@H]1CSCN1C(=O)[C@H]1NC(=O)CC1 UUTKICFRNVKFRG-WDSKDSINSA-N 0.000 description 1
- 241000589151 Azotobacter Species 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 238000006298 dechlorination reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 231100000584 environmental toxicity Toxicity 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000010303 mechanochemical reaction Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 231100001239 persistent pollutant Toxicity 0.000 description 1
- 229960001163 pidotimod Drugs 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 238000005381 potential energy Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002786 root growth Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE NOT OTHERWISE PROVIDED FOR
- B09B3/00—Destroying solid waste or transforming solid waste into something useful or harmless
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Engineering & Computer Science (AREA)
- Environmental & Geological Engineering (AREA)
- Processing Of Solid Wastes (AREA)
Abstract
The invention relates to a method for harmlessly treating overdue drugs, which comprises the steps of crushing and grinding waste oyster shells through a 0.2mm sieve, mixing the crushed oyster shells with the overdue drugs, placing the mixture into a stainless steel tank body of a planetary ball mill, adding stainless steel balls, covering the tank body, and then carrying out harmless treatment on the overdue drugs at a rotating speed of 250r/min for 4 hours according to a ball mill loading mode. The technology of the invention fully utilizes the adsorption and fixation characteristics of the waste oyster shell calcium carbonate, realizes the harmless treatment of overdue medicines under the action of mechanical kinetic energy degradation, and has better environmental and social benefits.
Description
Technical Field
The invention belongs to the technical field of harmless treatment and disposal of wastes, and relates to a harmless treatment technology for overdue medicines.
Background
The problem of environmental pollution caused by human and livestock drugs is one of the troublesome problems of the current environmental pollution prevention and management, the problem of the proliferation of drug resistance genes and the appearance of super bacteria threaten human health and social sustainability. The improper disposal of overdue drugs is one of the important ways for drugs to enter the environment, and according to statistics, about 70% of the drugs in household medicine boxes are idle to be overdue, and more than 88% of the overdue drugs are discarded along with domestic garbage or poured into toilets, water tanks and the like to enter the environment, so that drug pollution of environmental media and corresponding ecological risks are caused. Therefore, development of a harmless treatment technology of overdue drugs has important practical significance for drug environmental risk management and control.
Disclosure of Invention
The invention aims to realize harmless treatment of overdue drugs by utilizing the principle that energy is provided by mechanical ball milling to degrade organic pollutants and fully utilizing the component characteristics of waste oyster shells.
In order to achieve the purpose, the technical scheme adopted by the invention is developed as follows:
a method for harmlessly treating expired drugs comprises the following steps:
step 1: mechanically crushing and grinding the waste oyster shells, and sieving the crushed and ground oyster shells through a sieve pore of 0.2mm to obtain oyster shell powder;
step 2: mixing oyster shell powder and overdue medicines according to a weight ratio of 1:60, and placing the mixture in a stainless steel tank of a planetary ball mill;
and step 3: and (3) mixing the mixture with stainless steel balls according to the weight ratio of 1:60 adding stainless steel balls with the diameter of 3mm into the tank body;
and 4, step 4: after the stainless steel tank body is covered, the stainless steel tank body is safely loaded in a planetary ball mill and runs for 4 hours at the rotating speed of 250 r/min;
and 5: and naturally cooling to obtain harmless matter.
The waste oyster shells in the step 1 are coastal cultured oysters, and the waste oyster shells after meat taking are harvested.
The waste oyster shells in the step 1 are crushed, ground and sieved by a sieve with 0.2mm mesh so as to obtain fine granular powder, and conditions are provided for full contact between effective ingredients of the oyster shells and overdue medicines.
The overdue medicines in the step 2 are commonly used granular, flaky and powdery solid medicines.
The stainless steel ball in the step 3 is used for ensuring that enough kinetic energy and potential energy are generated during collision and the stainless steel ball and overdue drugs are subjected to mechanochemical reaction, and the rotating speed and the time of the ball mill are set to ensure a good ball milling process so as to obtain a harmless treatment result.
On the basis of the principle that energy is provided by mechanical ball milling to degrade organic pollutants, the adsorption and fixation properties of the active ingredients of the oyster shells are fully considered, and the overdue drugs are harmlessly treated by the optimized proportion of the overdue drugs and the waste oyster shell powder and the research and comparison of the parameters such as the addition amount of ball-milled stainless steel balls, the ball-milling rotating speed, the ball-milling time and the like.
95% of oyster shell component is calcium carbonate, have porous characteristic, the specific surface area is large, after interacting with overdue pharmaceutical active ingredient, can reach the fixed effect of absorption, help the detoxification of pharmaceutical active ingredient. After the porous material adsorbs overdue medicine active ingredients, the degradation of organic matters is accelerated in the energy transfer process of mechanical ball milling. Therefore, the oyster shell mainly plays a role in adsorbing and fixing the overdue medicinal effective components, so that the contact collision between the medicinal components and the mechanical steel ball is improved, and the effects of degradation and detoxification are achieved.
In the existing case, calcium oxide or zero-valent iron is added to provide a chloride ion receiving carrier to be changed into calcium chloride or ferric chloride in the process of degrading organic pollutants by mechanical ball milling, so that dechlorination and effective degradation of the organic pollutants, particularly the chlorine-containing organic pollutants are realized. Most of overdue medicines do not contain halogen elements, the chemical stability is not high as persistent pollutants, and the high-cost auxiliary agent of zero-valent iron is not required to be added. In addition, oyster shell is used as a breeding waste, and the treatment and disposal of oyster shell are a big environmental problem which troubles coastal oyster breeding areas. Oyster shell is used as an auxiliary agent for mechanical degradation of overdue medicaments, and the method is a way for recycling oyster shell. And the overdue medicine is treated by a mechanical ball milling method to realize harmlessness, so that the method is not reported at present, is an effective technology for harmlessly treating the overdue medicine, and is a new content for degrading pollutants by mechanical ball milling.
The treatment technology has the following advantages:
1) the mechanical kinetic energy is utilized to degrade the effective components of the overdue medicines, so that the method has the characteristics of rapidness, convenience and no secondary pollution;
2) the characteristics of the active ingredients of the oyster shell waste are fully utilized, the recycling of regional waste is facilitated, and the environmental pressure of the waste is reduced;
3) the simple treatment process of the mechanical ball milling is beneficial to the production and popularization of equipment of the treatment technology;
4) the treated overdue medicine can realize harmlessness to environmental microorganisms and plant root growth.
Drawings
FIG. 1 illustrates a harmless powder formed after mechanical ball milling of an expired medicament;
FIG. 2 shows the evaluation effect of nitrogen-fixing bacteria inhibition of the powder leaching liquor after mechanical ball milling of overdue drugs.
Fig. 1 illustrates that the overdue drugs form white powder after harmless treatment by mechanical ball milling, and the powder also helps to separate steel balls from the powder, thereby realizing industrial equipment automation. Fig. 2 shows that the overdue drugs have obvious inhibitory effect on the growth of nitrogen-fixing flora, but after mechanical ball milling, the obtained powder leaching liquor has no obvious inhibitory effect on the growth of nitrogen-fixing flora, the growth curve of the powder leaching liquor is close to the growth trend of normal flora, and the overdue drugs achieve harmless effect.
Detailed Description
The present invention is further illustrated with reference to the following specific examples, but the scope of the present invention is not limited thereto.
Example of the implementation
A method for harmlessly treating expired drugs comprises the following steps:
(1) collecting the commonly overdue antibiotic drug pidotimod particles, removing the external package, and mixing;
(2) collecting waste oyster shells in a coastal oyster culture area, and obtaining oyster shell powder by mechanical crushing, mechanical grinding and sieving through a sieve pore of 0.2 mm;
(3) fully and uniformly mixing the prepared oyster shell powder and overdue medicines according to the mass ratio of 1: 60;
(4) mixing the mixture with a steel ball with the diameter of 3mm according to the proportion of 1:60 percent of the mixture is mixed and placed in a ball mill, and the ball mill is operated for 4 hours at the rotating speed of 250r/min, so that the harmless treatment is realized.
The harmless effect evaluation test was as follows:
test strains: azotobacteria
Liquid LB medium: weighing 10g Tryptone (Tryptone), 5g Yeast extract (Yeast extract) and 5g NaCl, diluting to 1L with deionized water, adjusting pH to 7.4 with 1mol/L NaOH, and sterilizing for 20 min.
The sample after ball milling treatment of the embodiment is shown in figure 1, the mixture after ball milling is taken out, deionized water is added according to the water-soil ratio of 1:10 (ml: g), the mixture is shaken for 30min, and after centrifugation, the supernatant is taken for evaluating the inhibition effect of the bacterial growth activity.
The result shows that compared with the growth trend of normal strains, the leaching liquor of the medicament without ball milling has obvious inhibiting effect on the growth of the azotobacter, which indicates that the overdue medicament still has obvious ecotoxicity effect; after the treatment by the method, the growth tendency of the mixture leaching liquor on the nitrogen-fixing bacteria is consistent with the normal growth tendency of the bacteria, and a good harmless effect is shown (shown in figure 2). The overdue medicine treated by the method can achieve the harmless effect.
The above description is only a preferred embodiment of the present invention, and all equivalent changes and modifications made in accordance with the claims of the present invention should be covered by the present invention.
Claims (1)
1. A method for harmlessly treating expired drugs is characterized by comprising the following steps:
step 1: mechanically crushing and grinding the waste oyster shells, and sieving the crushed and ground oyster shells through a sieve pore of 0.2mm to obtain oyster shell powder;
step 2: mixing oyster shell powder and overdue medicines according to a weight ratio of 1:60, and placing the mixture in a stainless steel tank of a planetary ball mill;
and step 3: and (3) mixing the mixture with stainless steel balls according to the weight ratio of 1:60 adding stainless steel balls with the diameter of 3mm into the tank body;
and 4, step 4: after the stainless steel tank body is covered, the stainless steel tank body is safely loaded in a planetary ball mill and runs for 4 hours at the rotating speed of 250 r/min;
and 5: naturally cooling, and taking out the substances from the tank body to obtain harmless substances;
the waste oyster shells in the step 1 are coastal culture oysters, and the waste oyster shells after meat taking are harvested;
the overdue medicines in the step 2 are commonly used granular, flaky and powdery solid medicines.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110493382.6A CN113102473B (en) | 2021-05-07 | 2021-05-07 | Overdue medicine harmless treatment method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110493382.6A CN113102473B (en) | 2021-05-07 | 2021-05-07 | Overdue medicine harmless treatment method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113102473A CN113102473A (en) | 2021-07-13 |
| CN113102473B true CN113102473B (en) | 2022-07-05 |
Family
ID=76721051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110493382.6A Active CN113102473B (en) | 2021-05-07 | 2021-05-07 | Overdue medicine harmless treatment method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113102473B (en) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8535711B2 (en) * | 2004-01-23 | 2013-09-17 | Teikoku Pharma Usa, Inc. | Medication disposal system |
| CN102166577B (en) * | 2010-12-07 | 2012-10-24 | 清华大学 | Method for destroying chloric persistent organic waste through iron and quartz sand high-energy ball milling |
| CN104784863A (en) * | 2014-07-23 | 2015-07-22 | 北京师范大学 | Persulfate enhanced ball-milling treatment method of chemical waste |
| CN104874452A (en) * | 2015-05-13 | 2015-09-02 | 成都中牧生物药业有限公司 | Device for processing overdue spice |
| WO2018052870A1 (en) * | 2016-09-13 | 2018-03-22 | Board Of Regents, The University Of Texas System | Drug disposal system |
| CN108826305A (en) * | 2018-07-24 | 2018-11-16 | 陈春女 | A kind of discarded tablet environmental protection apparatus for destroying of the Western medicine based on roller breakdown mill technology |
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2021
- 2021-05-07 CN CN202110493382.6A patent/CN113102473B/en active Active
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