CN113082125A - Traditional Chinese medicine for clearing lung and abating fever and application thereof - Google Patents

Abstract

The invention discloses a lung-clearing and fever-abating traditional Chinese medicine and application thereof in preparing a medicine for treating acute upper respiratory tract infection, wherein the lung-clearing and fever-abating traditional Chinese medicine is prepared from, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of fried scutellaria baicalensis, 4-9 parts of perilla leaf, 4-9 parts of mint, 4-9 parts of radix peucedani, 4-9 parts of bupleurum chinense, 15-30 parts of sweet wormwood herb, 15-30 parts of folium isatidis, 4-9 parts of blackberry lily, 4-12 parts of platycodon grandiflorum, 4-12 parts of cortex mori, 4-12 parts of thunberg fritillary bulb, 4-15 parts of radix angelicae and 9-15 parts of medicated leaven. The Chinese medicinal composition is used for treating acute upper respiratory tract infection, can obviously accelerate the relief of symptoms such as fever and the like, and promotes the recovery of diseases; the traditional Chinese medicine has the effects of clearing lung, abating fever and the like, and has reliable curative effect; the raw materials are easy to obtain, the price is low, the preparation is convenient, and the application range is wide.

Description

Traditional Chinese medicine for clearing lung and abating fever and application thereof

Technical Field

The invention relates to the field of traditional Chinese medicine formulas for treating fever, in particular to a traditional Chinese medicine formula granule composition for treating patients with acute upper respiratory infection of 10 years old and above.

Background

Acute upper respiratory infection is a general term for acute inflammation of nasal cavity, pharynx or larynx caused by virus or bacteria, usually with many viruses, and is the most common infectious disease of respiratory tract, not only having strong infectivity, but also causing serious complications. The related documents show that the infection caused by the virus accounts for 70-80%, the main infection of the virus is the bacterial infection such as influenza virus (A, B and C), rhinovirus, parainfluenza virus, respiratory syncytial virus, adenovirus, echovirus, coxsackie virus, measles virus, rubella virus and the like can be directly or more secondary to the infection of the virus, hemolytic streptococcus is more common, haemophilus influenzae, streptococcus pneumoniae, staphylococcus, mycoplasma, chlamydia and the like are more common, and gram negative bacillus occasionally has rhinitis, pharyngolaryngitis or tonsillitis according to the infection parts

Due to catching cold, rain, over fatigue and other reasons, the defense function of the body is reduced, or the body can rapidly propagate in local parts to mutated virus lack immunity virus or bacteria, so that the disease is more likely to be caused, especially for the old, young, weak or chronic respiratory disease patients, and is the main cause of repeated attack of chronic bronchitis.

Because symptoms such as fever, cough, pharyngalgia, nasal obstruction, watery nasal discharge, headache, hypodynamia, intolerance of cold and the like in the acute stage and secondary diseases often bring influence to the life of a patient, no ideal antiviral drug and long-term effective antibacterial drug exist in western medicine so far, and symptomatic treatment is mainly adopted.

Disclosure of Invention

The invention aims to provide a lung-clearing fever-abating traditional Chinese medicine formula granule composition capable of obtaining an effective, remarkable, lasting and stable treatment result aiming at acute upper respiratory tract infection and application thereof.

When the traditional Chinese medicine formula particle composition is used for treating acute upper respiratory infection, the relief of symptoms such as fever and the like can be obviously accelerated, and the recovery of diseases is promoted; the traditional Chinese medicine has the effects of clearing lung, abating fever and the like, and has reliable curative effect; the raw materials are easy to obtain, the price is low, the preparation is convenient, and the application range is wide.

In order to solve the problems, the invention adopts the technical scheme that:

a traditional Chinese medicine for clearing lung and relieving fever (namely a traditional Chinese medicine formula particle composition for treating acute upper respiratory infection) is prepared from 15-30 parts by weight of wild buckwheat rhizome, 9-15 parts by weight of fried scutellaria baicalensis, 4-9 parts by weight of perilla leaf, 4-9 parts by weight of mint, 4-9 parts by weight of bupleurum chinense, 15-30 parts by weight of sweet wormwood herb and 15-30 parts by weight of folium isatidis. (the pharmaceutical formulation is the basic formulation for the treatment of patients with acute upper respiratory infections).

A traditional Chinese medicine formula particle composition for treating acute upper respiratory infection comprises, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of fried scutellaria baicalensis, 4-9 parts of perilla leaf, 4-9 parts of mint, 4-9 parts of bupleurum chinense, 15-30 parts of sweet wormwood herb, 15-30 parts of folium isatidis, 4-9 parts of blackberry lily, 4-12 parts of platycodon grandiflorum, 4-12 parts of white mulberry root-bark and 4-12 parts of thunberg fritillary bulb. (the formula of the medicine is mainly used for treating acute upper respiratory tract infection patients with wind-cold transforming heat and phlegm-dampness obstructing lung).

A traditional Chinese medicine formula particle composition for treating acute upper respiratory infection comprises, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of fried scutellaria baicalensis, 4-9 parts of perilla leaf, 4-9 parts of mint, 4-9 parts of bupleurum chinense, 15-30 parts of sweet wormwood herb, 15-30 parts of folium isatidis and 4-15 parts of angelica dahurica. (the medicine formula is mainly used for treating the acute upper respiratory tract infection patient suffering from wind-heat attack).

A traditional Chinese medicine formula particle composition for treating acute upper respiratory infection comprises, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of fried scutellaria baicalensis, 4-9 parts of perilla leaf, 4-9 parts of mint, 4-9 parts of bupleurum chinense, 15-30 parts of sweet wormwood herb, 15-30 parts of folium isatidis, 9-15 parts of medicated leaven, 9-15 parts of fried malt and 9-15 parts of scorched hawthorn fruit. (the medicine formula is mainly used for treating acute upper respiratory tract infection patients with wind-cold heat and lung and stomach disorder).

A traditional Chinese medicine formula particle composition for treating acute upper respiratory tract infection is composed of, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of fried scutellaria baicalensis, 4-9 parts of perilla leaf, 4-9 parts of mint, 4-9 parts of radix peucedani, 4-9 parts of bupleurum chinense, 15-30 parts of sweet wormwood herb, 15-30 parts of folium isatidis, 4-9 parts of blackberry lily, 4-12 parts of platycodon grandiflorum, 4-12 parts of cortex mori, 4-12 parts of thunberg fritillary bulb, 4-15 parts of radix angelicae and 9-15 parts of medicated leaven (the medicine formula is mainly used for treating patients with acute upper respiratory tract infection caused by wind-cold-induced heat, phlegm-dampness obstructing lung and stomach disorder). Further preferably, 15 parts of fried scutellaria baicalensis, 9 parts of perilla leaves, 30 parts of folium isatidis, 9 parts of mint, 12 parts of platycodon grandiflorum, 9 parts of radix peucedani, 9 parts of bupleurum chinense, 12 parts of cortex mori, 12 parts of thunberg fritillary bulb, 15 parts of angelica dahurica, 15 parts of medicated leaven (namely charred medicated leaven), 30 parts of sweet wormwood herb, 30 parts of wild buckwheat rhizome and 9 parts of blackberry lily.

The invention relates to a traditional Chinese medicine formula granule composition for treating acute upper respiratory infection, which comprises the following components in part by weight: the traditional Chinese medicine formula particle composition for treating acute upper respiratory infection provided by the invention is prepared for 1 person, 1 dose is taken per day in grams (g) and divided into 2 bags, the traditional Chinese medicine formula particle composition is taken 1 time by one time, 100-200 ml of warm boiled water is taken each time, and the warm boiled water is taken 1 time in the morning and evening respectively. The traditional Chinese medicine formula particle composition for treating acute upper respiratory infection can also be prepared for multiple people, the amount of 1 person in the formula is multiplied by the number of people needing to take the formula particles according to the formula composition provided by the invention, the corresponding needed traditional Chinese medicine formula particles are taken for brewing, the juice amount is multiplied by the needed amount of each person, and the traditional Chinese medicine formula particle composition can be taken 1 time warmly in the morning and evening.

The pharmacological actions of various raw materials of the invention are as follows:

wild buckwheat rhizome:

the product is slightly pungent, astringent and cool in nature, and enters lung meridian. The product has effects of clearing away heat and toxic materials, relieving swelling, relieving sore throat, and dispelling pathogenic wind and dampness. It is often used for cough due to lung heat, lung abscess, purulent phlegm, swelling and pain of throat, stomach ache, dyspepsia, dysentery, common cold, rheumatalgia, traumatic injury, lumbago, leg pain, skin sore, carbuncle, toxic swelling, and lyssodexis. The product contains fagopyrum tataricum glycoside, which is hydrolyzed to generate coumaric acid, ferulic acid and glucose. Each part contains flavone components such as rutin, leaves and fruits contain flavone components such as rutin and cyanidin, and contains procyanidine, hecogenin and beta-sitosterol. In addition, the extract contains effective components such as tannin and volatile oil. The product has the following pharmacological effects: 1. the antibacterial effect is as follows: the Jinyangmai extract can obviously inhibit the activity of the extracellular heat-resistant nuclease of staphylococcus aureus, has obvious bacteriostatic action on staphylococcus aureus, escherichia coli, bacillus subtilis, bacillus thuringiensis and diplococcus kalae, and has obvious bacteriostatic action on flagellate bacteria, candida albicans and other fungi; 2. cough relieving, phlegm eliminating and anti-inflammatory effects: rhizoma Fagopyri Dibotryis extract has effects of relieving cough, eliminating phlegm and resisting inflammation; 3. the anti-tumor effect is as follows: the wild buckwheat rhizome extract has obvious anti-tumor effect, and in-vitro cell direct killing experiments prove that the wild buckwheat rhizome extract has obvious killing effect on human cancer cells such as lung adenocarcinoma cells (GLC), cervical squamous carcinoma cells (HeLa), gastric adenocarcinoma cells (SGC-7901), nasopharyngeal squamous carcinoma cells (KB) and the like, and the killing effect and the inhibition effect are obviously enhanced along with the increase of the mass concentration of the medicament. The wild buckwheat rhizome has the functions of obviously killing various human cancer cells, inhibiting the growth and proliferation of stem cells of the human cancer cells and inhibiting DNA synthesis, the wild buckwheat rhizome extract can obviously inhibit the nucleic acid metabolism in the cancer cells, and the inhibition effect of the wild buckwheat rhizome extract is similar to that of positive control fluorouracil with the same mass concentration; DFr4 and CTX have additive effect on inhibiting the growth of transplanted tumor S180 and liver cancer H22, and can antagonize bone marrow depression caused by CTX; 4. antioxidation: the dibosilside A and lapathiide A separated from wild buckwheat rhizome have weak antioxidation, and ethanol extract with volume fraction of 70% of wild buckwheat rhizome has in vitro lipid peroxidation resistance; 5. enhancing the immune function: the wild buckwheat rhizome medicated serum has obvious dose-effect and time-effect relationship on the proliferation activity of splenic lymphocytes; 6. h1 receptor blockade: the wild buckwheat rhizome slice (wild buckwheat rhizome extract) can resist the in vitro guinea pig enteromorphic contraction reaction caused by histamine, and has obvious dose-effect and aging relationship; 7. Inhibition of platelet aggregation: the flavanol can inhibit platelet aggregation of rat induced by ADP and Staphylococcus aureus in vitro, and the action intensity is enhanced with dosage.

Shooting:

being bitter and pungent in flavor and cold in nature, it enters lung, liver and spleen meridians. The product has effects of clearing away heat and toxic materials, clearing lung-heat, eliminating phlegm, dispelling blood stasis, and relieving swelling, and can be used for treating stagnation of phlegm-fire, sore throat, phlegm cough, asthma, etc. due to toxic heat, and is widely used for treating upper respiratory infection, suppurative tonsillitis, etc. The product contains flavonoids, isoflavones and their derivatives, ketones, phenols, benzoquinones, bicyclic triterpenes, steroids and volatile components. Wherein the isoflavone compounds are irisflavone, tectorigenin, irigenin, genistein, dimethyl tectorigenin, sub-wild tectorigenin, tectorigenin A, tectorigenin B, tectoridin, 6 '-O-vanilloyl wild tectoridin, 2, 3-dihydro wild tectorigenin, 6' -D-p-hydroxybenzoyl wild tectoridin, wild tectoridin, Belamcandin, 5,7, 3 '-trihydroxy-8, 4' -dimethoxy isoflavone, demethyl sub-wild tectorigenin and Belamcandin A. The flavonols include isorhamnetin and 3' -O-methyl rhamnonin. Triterpene fatty acids, and the like. The product has the following pharmacological effects: 1. anti-inflammatory and anti-tumor activity: tectorigenin and tectoridin both inhibit prostaglandin E2 production induced by protein kinase C activator, 12-O-tetracapryl crotonyl alcohol-13-acetate (TPA) or inner membrane Ca2+ -ATPase inhibitor in rat peritoneal macrophage; 2. and (3) scavenging free radicals: wild tectoridin, tectorigenin, tectoridin and 5,6,7, 4' -tetrahydroxy-8-methoxy isoflavone all have the function of scavenging free radicals; 3. estrogen-like action: tectorigenin and wild tectorigenin (50-100. mu. mol/L) were effective in reducing the cell number of these 3 cell lines. Two phytoestrogens inhibit the proliferation of cancer cells by regulating cell cycle, thereby reducing the number of prostate cancer cells; 4. antioxidant and anti-hepatotoxic effects: tectoridin and its aglycone can significantly reduce serum transaminase activity due to liver injury, and greatly enhance activities of antioxidase such as superoxide dismutase, catalase and glutathione peroxidase in liver cell sap. Tectoridin and aglycone thereof not only have antioxidant effect, but also have liver protecting effect; 5. The antibacterial effect is as follows: the blackberry lily has stronger inhibition effect on the multiple drug-resistant strains; 6. effects on the digestive system and experimental thrombosis: 5g/kg of blackberry lily 75% ethanol extract and 15g/kg of blackberry lily can inhibit the formation of mouse indometacin-ethanol gastric ulcer, and only has inhibition tendency on the formation of hydrochloric acid and water immersion stress gastric ulcer; 7. toxic fish activity: both n-hexane extract and ether extract showed toxic fish activity, and they were found to have cytotoxic effects on P388 lymphocytes, but most of the single-ring iris compounds did not show toxic fish activity.

Parching radix Scutellariae:

this herb is bitter in flavor and cold in nature, and enters spleen, lung, small intestine, gallbladder and large intestine meridians. The product has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substances, stopping bleeding, and preventing miscarriage. It is often used to treat fever, chest distress, thirst, dysentery, jaundice; cough, dry cough with little phlegm, asthma, etc. caused by lung heat; epistaxis, hematemesis, hemoptysis, hematemesis, etc. due to blood heat. The product mainly contains flavonoids such as baicalin, baicalein, wogonin, and baicalein. Also contains volatile oil components such as acetophenone, palmitic acid, and oleic acid, beta-sitosterol, and baicalinase. The product has the following pharmacological effects: 1. the antibacterial effect is as follows: the scutellaria decoction has different degrees of inhibition effects on gram-positive bacteria such as staphylococcus aureus, hemolytic streptococcus, pneumococcus and the like and gram-negative bacteria such as escherichia coli, dysentery bacillus, pseudomonas aeruginosa and the like in vitro; 2. the antiviral effect is as follows: the Scutellariae radix decoction and water can inhibit influenza A virus and hepatitis B virus; 3. Anti-allergic effect: baicalin and baicalein have inhibitory effect on acute and chronic inflammation, and can reduce capillary permeability and reduce release of allergic medium; 4. the antipyretic effect is as follows: baicalin, total flavonoids of scutellaria and the like have obvious antipyretic effect; 5. the antidepressant effect is as follows: the scutellaria aqueous extract can improve depression symptoms through ways of reducing the level of inflammatory cytokines, regulating neurogenesis channels and the like; 6. the anticancer effect is as follows: baicalin induces apoptosis of colon cancer cells and inhibits tumor growth by reducing the expression of c-Myc (protooncogene) and oncomiRs (RNA molecules that affect energy supply of cancer cells).

Perilla leaf:

it is pungent, slightly warm, nontoxic, and enters spleen and lung meridians. The product has effects of relieving exterior syndrome, dispelling cold, activating qi-flowing, and regulating stomach function, and can be used for treating wind-cold type common cold, cough emesis, vomiting of pregnancy, fish and crab poisoning. The product contains volatile oil, flavone, anthocyanin, phenolic acid, glycoside, triterpene and steroid. Wherein the volatile oil comprises linalool, linalyl acetate, neryl acetate, geranyl acetate, citral, geranial, vanillyl alcohol, chrysolone, isochrysolone, perillyl ketone, perillyl ene, elsholtzone, menthane (menthane) -type levo-limonene, gamma-terpinene, terpinolene, and terpinyl acetate. Aromatic components include methyl eugenol, apiol, myristyl ether, asarone, dill naphtha, safrole, styrene, dimethyl phthalate and 1, 3-dimethyl benzene, and aliphatic components include neophytadiene, 7-octene-4-alcohol and jasmone. The flavone components comprise apigenin, apigenin-7-glucoside, apigenin-7-O-diglucoside, apigenin-7-caffeoylglucoside, luteolin-7-glucoside, luteolin-7-O-diglucoside, luteolin-7-caffeoylglucoside, chrysoeriol, scutellarin-7-O-diglucoside, scutellarin and baicalein-7-methyl ether. The anthocyanin components include pelargonidin, cyanidin, paeoniflorin-3-glucoside, paeoniflorin-3- (6' -acetyl) glucoside, caffeoyl anthocyanin, perillarine, cis-perillarine, malonyl perillarine, and malonyl-cis-perillarine. Phenolic acid components including rosmarinic acid and cinnamic acid derivatives. Glycoside compounds including monoterpene glycoside, phenylpropanoid, glycoside cyanogenic glycoside, elderberry glycoside, alcohol glycoside, 3-beta-D-glucopyranoside of benzene valeric acid and daucosterol. Triterpenes and steroids, including oleanane (oleana) type triterpenes, ursane type triterpenes and sterols. The product has the following pharmacological effects: 1. protecting cardiovascular system and cerebrovascular system, inhibiting platelet aggregation, nourishing myocardium, increasing coronary blood flow, dilating rat artery blood vessel with perillaldehyde, resisting thrombi with linolenic acid, and relieving focal cerebral ischemia injury of mouse with perilla essential oil; 2. antioxidant and antibacterial effects, flavonoids can effectively remove oxygen free radicals, rosmarinic acid can effectively remove superoxide, and Perillae herba extract can prevent lipid peroxidation. The perilla extract has a wide range of antibacterial activity, and it is presumed that its antibacterial active ingredient may be present in compounds such as flavone, volatile oil, organic acid, phenol, etc. The perilla essential oil can inhibit the growth of bacteria to a certain extent, and the bacteria can be completely killed when the concentration is high enough; 3. blood fat and blood sugar are reduced: the perilla seed is rich in alpha-linolenic acid, has the effects of reducing blood fat and blood pressure, arachidonic acid in platelets can be converted into thromboxane and prostacyclin under the action of cyclooxygenase, and the alpha-linolenic acid in the perilla seed can reduce the level of arachidonic acid so as to play a role in resisting thrombus.

Mint:

it is pungent in flavor and cool in nature, entering lung and liver meridians. The product has effects of dispelling pathogenic wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing. It is mainly used for treating affection of exogenous wind-heat, headache, sore throat, food stagnation, flatulence, aphtha, toothache, scabies, urticaria, early stage of epidemic febrile disease, rubella pruritus, stagnation of qi due to depression of the liver, chest distress, and hypochondriac pain. The product contains volatile oil, flavonoids, amino acids, organic acids, terpenes, and quinones. Wherein the volatile oil contains sesquiterpene volatile components such as levomenthol, peppermint, levorotatory mint, pulegone, etc. The flavonoids include luteolin-7-glucoside, acacetin-7-O-neohesperidoside, isoflavone glycoside, isorfurin, hesperidin, diosmetin-7-O-glucoside, beta-daucosterol, etc. The amino acids include lysine, histidine, tyrosine, valine, arginine, and aspartic acid. The organic acid component comprises: rosmarinic acid, caffeic acid, benzoic acid, trans-cinnamic acid, etc. The terpenes include pentacyclic triterpenes and monocyclic monoterpenes. The quinones include emodin, chrysophanol, physcion, aloe-emodin, ursolic acid, daucosterol, trans-cinnamic acid, benzoic acid, and beta-orynol. The pharmacological action of the product is as follows: 1. action on the central nervous system: the Mentha rotundifolia essential oil and Mentha piperita essential oil can regulate the content of amino acid neurotransmitter in brain region related to mental fatigue by using olfaction. The menthol can block the internal flow of sodium ions, thereby generating local nerve block and playing the role of analgesia; 2. the antiviral and antibacterial effects are as follows: the mint polysaccharide and the mint oil have strong inhibition effect on respiratory syncytial virus and herpes simplex virus. The herba Menthae decoction can be used for resisting Staphylococcus epidermidis, Staphylococcus aureus, Bacillus proteus, Pseudomonas aeruginosa, Escherichia coli, and Streptococcus pneumoniae. Peppermint oil also has fungicidal activity; 3. action on digestive system: menthol and menthone both have choleretic effect; 4. acting on the respiratory system: menthol can increase the secretion of respiratory mucus, reduce the foam sputum of the respiratory tract, reduce the weight of the secretion, enlarge the effective ventilation cavity and dilute the thick mucus for easy discharge; 5. local anesthetic action: menthol and menthone both have skin stimulating effects. The menthone has effects of local anesthesia and relieving pain, and has stronger skin irritation than menthol, and its ethanol solution has antiseptic effect.

Balloon flower:

being bitter and pungent in flavor and neutral in nature, it enters lung meridian. The product has effects of dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus. It is mainly suitable for cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung carbuncle, and purulent vomiting. The product mainly contains saponins, flavonoids, polysaccharide, fatty acid, and inorganic elements. The saponins include oleanolic acid type pentacyclic triterpene saponin, radix Platycodi acid (platycodin A), mandelic acid (platycodin B), and platycodin D. The flavonoids mainly comprise flavanone, flavone and flavonoid glycoside compounds. The polysaccharide includes platycodon grandiflorum polysaccharide GF 2-GF and inulin. The fatty acid includes linoleic acid, palmitic acid, linolenic acid, stearic acid, oleic acid, and palmitic acid. The radix Platycodi contains inorganic elements such as Fe, Mn, Co, Zn, Cr, Mg, Ca, Sr, Li, etc. The pharmacological action of the product is as follows: 1. relieving cough and asthma: the platycodon grandiflorum water extract achieves the purpose of eliminating phlegm by increasing the secretion of respiratory mucosa. The platycodon grandiflorum has a promoting effect on LXA4 release of asthma guinea pigs, can also promote secretion of IFN-gamma, and indirectly plays a role in regulating balance of Th1/Th 2; meanwhile, the generation and the release of oxygen free radicals can be reduced; 2. anti-inflammatory and bacteriostatic effects: with the increase of the concentration of the platycodin D, the change of candida albicans from a spore phase to a hypha phase is gradually reduced, and the adhesion number and the bacterial activity of the candida albicans are gradually reduced; 3. the anti-tumor effect is as follows: platycodin D, platycodin D3 and polygalin D can inhibit the proliferation of a Bel-7402 cell line of human liver cancer, a BGC-823 cell line of human stomach cancer and a MCF-7 cell line of human breast cancer, wherein the platycodin D has the strongest inhibition effect; 4. the hypoglycemic effect: the platycodon grandiflorum polysaccharide can also improve the activity of superoxide dismutase in liver tissues, reduce the content of malondialdehyde, improve the fasting insulin level and improve the oxidation resistance; 5. antioxidation: the platycodin D and the platycodin D both have better capacity of eliminating free radicals in vitro and have stronger activity than ascorbic acid with the same concentration; 6. liver protection: the platycodin substances have a good protective effect on liver injury, and the platycodin D has an anti-hepatic fibrosis effect, and can reduce the expression level of a hepatic tissue transformation growth factor-beta 1 (TGF-beta 1) and increase the expression level of bone morphogenetic protein-7 (BMP-7) by inhibiting the cell proliferation and activation of hepatic stellate cells, so that the anti-hepatic fibrosis effect is achieved.

Radix peucedani:

this herb is bitter and pungent in flavor and slightly cold in nature, entering lung meridian. The product has effects of lowering qi, eliminating phlegm, dispelling pathogenic wind, and clearing away heat. It is suitable for treating phlegm-heat type dyspnea with fullness and distention, yellow and thick phlegm, cough due to wind-heat type, and excessive phlegm. The product mainly contains coumarins, inorganic elements, volatile oils, etc. Wherein the coumarins are Peucedanine A, Peucedanine B, Peucedanine C, Peucedanine D, Peucedanine E, bergapten, palmitic acid, imperatorin, tetracosanoic acid, 2, 6-dimethylquinoline, and daucosterol; inorganic elements including phosphorus, sulfur, silicon, barium, aluminum, chromium, zinc, manganese, rubidium, selenium, chromium, titanium, iron, palladium, cerium, zirconium, lanthanum, copper, tin, nickel, cesium, vanadium, yttrium, niobium, and the like; the volatile oils are beta-elemene, vanillin, beta-arborvitae, alpha-farnesene, etc.; others include tanshinone IIA and tanshinone, daucosterol, decursin, tetracosanoic acid, palmitic acid. The product has the following pharmacological effects: 1. the functions of resisting myocardial ischemia and protecting cardiac muscle are as follows: the peucedanum praeruptorum dunn extract can regulate the expression of related gene of myocardial cell apoptosis caused by abdominal aortic constriction, thereby inhibiting myocardial remodeling and playing a role in biological treatment on heart failure; 2. improving cardiac function: the peucedanum praeruptorum dunn extract can effectively improve the left ventricular contraction function of a patient, improve the blood supply of the body and relieve the heart failure symptom; 3. dilating blood vessels and reducing blood pressure: Pra-C can inhibit angiotensin II induced hypertrophy and proliferation of smooth muscle cells, reduce vascular smooth muscle intracellular [ Ca2+ ] and restore abnormal response of blood vessels to voltage-dependent and receptor-operated calcium channel agonists. The blood vessel hyperplasia and hypertrophy are improved from the aspects of reducing the area of smooth muscle cells, reducing the content of collagen, reducing [ Ca2+ ] and increasing the release amount of NO, and the like, so that the spontaneous hypertension is treated; 4. antioxidation: coumarins (TCP) in peucedanum praeruptorum dunn can obviously inhibit the generation of mouse liver homogenate Malondialdehyde (MDA), and the TCP is prompted to effectively inhibit lipid peroxidation; 5. the function of eliminating phlegm: the Peucedanum praeruptorum C and decursin can enhance mouse airway excretion of phenol red, and has expectorant effect; 6. the antibacterial effect is as follows: the volatile oil component in Peucedanum praeruptorum dunn has certain antibacterial activity on Escherichia coli, Salmonella typhi and Shigella flexneri.

Bupleurum chinense nakai:

this herb is bitter in flavor and cool in nature, entering heart, liver and spleen meridians. It has the actions of relieving exterior syndrome, relieving fever, soothing liver, and lifting yang qi. It is mainly used for treating fever due to exogenous pathogens, alternating chills and fever, malaria, liver depression, hypochondriac pain, distention, headache, dizziness, menoxenia, prolapse of anus, uterine prolapse, and gastroptosis due to qi deficiency sinking. The product mainly contains triterpenoid saponins, volatile oil, flavonoids, polysaccharides, etc. Triterpene saponins: saikosaponin is one of the main components of bupleurum chinense and is also one of the important activities of bupleurum chinense. The Saikosaponin isolated so far is an oleanane type derivative including Saikosaponin (saikospo-nin) a, d, c, S1, b2, v-2, 1, t, b3, f, q-1, q-2, 2 '-O-acetyl Saikosaponin a, 2' -O-acetyl Saikosaponin b2, 3 '-O-acetyl Saikosaponin b2, 3' -O-acetyl Saikosaponin d [ 9-14 ], saikosponin v-1, 6 '-O-acetyl Saikosaponin b2, 6' -O-acetyl Saikosaponin d. Wherein, the pharmacological research of the saikosaponin a is more deep, and the saikosaponin a has multiple nerve inhibition effects; the volatile oil mainly comprises gamma-cadinene, beta-ionone, lauric acid and myristic acid; the flavonoids are kaempferol, kaempferol-7-O-alpha-L-rhamnoside, kaempferol-3-O-alpha-L-furan, arabinose-7-O-alpha-L-chinaroot, rhamnose, kaempferitrin, quercetin-3-O-beta-D-glucoside, quercetin, rutin, parasitoside, isorhamnetin-3-O-beta-D-glucoside, narcissus, cactus glycoside, daidzin, puerarin, 7-hydroxy-2, 5-dimethyl-chromone and bupleurum chromone A respectively; the polysaccharides in bupleuri radix mainly comprise monosaccharide such as L-ara, D-rib, D-xyl, L-hra, D-glc, and D-gal. The product has the following pharmacological effects: 1. the antipyretic effect is as follows: the effective components with antipyretic effect in bupleuri radix are volatile oil component and saikosaponin component, which have obvious antipyretic effect on fever caused by typhoid, paratyphoid vaccine, Escherichia coli liquid, fermented milk, yeast, etc.; 2. tranquilizing, pain relieving and cough relieving effects: oral administration of crude saikosaponin has obvious sedative and hypnotic effects, and can prolong hypnotic time of barbital sodium and cyclohexapental sodium; 3. anti-inflammatory action: the anti-inflammatory active ingredients of the bupleurum are considered to be saikosaponin, and the ingredients have the inhibition effect on ankle swelling and connective tissue proliferative inflammation caused by various inflammatory agents, can reduce capillary permeability, reduce exudation of inflammatory factors, inhibit histamine release and leukocyte migration of inflammatory tissues, and have the inhibition effect on a plurality of links of inflammatory development; 4. the antiviral effect is as follows: the effective component saikoside in bupleuri radix and the saikoside generated secondarily have good inhibitory effect on influenza virus, hepatitis virus, vaccinia virus, type I spinal cord offwhite virus, herpes virus, etc. The compounds can inhibit Na + -K + -ATP enzyme of virus, influence energy and water salt metabolism of virus and play a role in resisting virus.

White mulberry root-bark:

it is sweet and cold in flavor and enters lung and spleen meridians. The product has effects in purging lung, relieving asthma, inducing diuresis, relieving swelling, tonifying deficiency, promoting blood circulation, dispelling blood stasis, eliminating phlegm, relieving cough, stopping bleeding, promoting salivation, quenching thirst, relieving constipation, expelling intestinal parasites, resolving food stagnation, expelling pathogenic wind, treating stranguria, and relieving pain. It is used clinically to treat edema, diabetes, tracheitis, pleuritis, pertussis and epistaxis. The product mainly comprises benzofuran compounds, stilbene compounds, flavonoids, coumarins, and other components. The benzofuran compound is prepared by using 2-phenyl benzofuran as main nucleus connected with common substituent or flavone compound; stilbene compounds include mainly:

alboctalol, andalasin B and macrourin B, D, etc.; the flavonoids mainly comprise morusin, morchelene, cyclosporine, morusin A-L, morusin C, D, morusin A-P, morusin alcohol, cyclosporine, morusin, hydroxyl dihydro morusin, morusin hydroperoxide and the like; the coumarin compounds mainly include 5, 7-hydroxycoumarin, scopoletin, umbelliferone, scopoletin, etc. Other compounds include ethyl 3, 4-dihydroxybenzoate, mulberry polysaccharide, mulberry furan, betulinic acid, stilbene glycoside compounds, chitosan, mucin, chitin, tannin, volatile oil, etc. The pharmacological action of the product is as follows: 1. analgesic and anti-inflammatory effects: the main component of the cortex mori radicis total flavonoids (400 mg.kg < -1 >) can obviously inhibit mouse auricle swelling caused by dimethylbenzene and capillary permeability increase caused by acetic acid, which indicates that the cortex mori radicis total flavonoids have stronger anti-inflammatory effect; 2. relieving cough, eliminating phlegm, relieving asthma and promoting urination: mulberroside can obviously reduce the cough times caused by sulfur dioxide (SO2), citric acid and strong ammonia water, has obvious asthma relieving effect on guinea pig bronchial asthma caused by histamine, can obviously increase the discharge amount of tracheal phenol red, and can also obviously increase the NO content in the bronchus, and the asthma relieving action mechanism is related to bronchial relaxation caused by the increase of the NO content in the bronchus. 3. The hypoglycemic effect: MTF has obvious blood sugar reducing effect and can improve osteoporosis and femoral head pathological changes caused by diabetes; 4. the effect of relaxing the heart and blood vessels: the effective parts of cortex Mori such as ethyl acetate extract and non-acetone extract have cardiovascular relaxing effect; 5. liver protection: white mulberry root bark Polysaccharide (PCM) inhibits the expression of Vascular Endothelial Growth Factor (VEGF), Platelet Derived Growth Factor (PDGF), messenger rna (mrna) in the liver; 6. the anticancer effect is as follows: the mulberry bark low chitosan and the volatile oil can effectively inhibit the growth of tumor cells and have obvious anticancer effect; 7. immunoregulation effect: the cortex Mori 30% ethanol fraction has effects of promoting humoral immunity and cellular immunity. The 50% ethanol component can inhibit growth of thymus gland, and has effects of inhibiting nonspecific immunity and cellular immunity, and the fatty oil component can promote humoral immunity; 8. antioxidation: cortex Mori flavone and 3 stilbene compounds (oxyresveratrol, resveratrol, and mulberroside) have strong biological activities of resisting oxidation and scavenging free radicals.

Thunberg fritillary bulb:

this herb is bitter in flavor and cold in nature, and enters heart and lung meridians. The product has effects of clearing heat, resolving hard mass, eliminating phlegm, and relieving cough. It is mainly used for treating wind-heat affecting lung, phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore, etc. The product mainly contains effective components such as alkaloid and total saponin, wherein the alkaloid comprises peimine, peiminine, thunbergine, thunbergtone, peiminine, beiminine, choline, peiminol, phytosterol, dehydroebeibidine, peiminine, ibesine, peiminine, obetidine, thunbergine, dehydropeiminine and isobeimine. The saponin includes peimine glycoside, sipelin glycoside, Thunberg peinin glycoside, peimine glycoside, ibeibaine glycoside A, and Pinebicine glycoside; also contains polysaccharide component. The pharmacological action of the product is as follows: 1. Cough relieving and phlegm dispelling: the fritillaria effective components peimine, peiminine, sipeimine glycoside and great bepeiminine five steroid alkaloids have antagonism on tracheal M receptor, and the alkaloid in thunberg fritillary acts on tracheal M receptor to generate antagonism and inhibit tracheal contraction; 2. pain relieving and antibacterial: the peiminine can increase the accumulation of antibiotics in the drug-resistant staphylococcus aureus by inhibiting an active efflux pump on a bacterial cell membrane, and can play a role in reversing the drug resistance of bacteria, wherein the reversing role is mainly played by regulating the immunity of an organism and improving the sensitivity of drug-resistant bacteria to the antibiotics; 3, antiulcer, anti-inflammatory and antidiarrheal: the thunberg fritillary bulb alcohol extract can inhibit water immersion stress and formation of hydrochloric acid gastric ulcer, inhibit acetic acid and improve permeability of abdominal capillary vessels to play a role in resisting inflammation; 4. and (3) tumor resistance: the anti-tumor components in the fritillaria are mainly alkaloids, wherein the main alkaloids mainly comprise peimine and peiminine, which have the effect of reversing the drug resistance of tumor cells and can have the synergistic effect with other anti-tumor drugs, thereby providing an effective way for treating tumors.

Radix angelicae:

it is pungent in flavor and warm in nature, entering lung, spleen and stomach meridians. The product has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, stopping leukorrhagia, and relieving swelling and pus discharge. It is mainly used for treating headache, supraorbital pain, toothache, nasosinusitis, cold-dampness, abdominal pain, intestinal wind, hemorrhoid, leucorrhea with reddish discharge, carbuncle, cellulitis, pyocutaneous disease, skin pruritus, scabies and tinea. The main components of the product comprise coumarins, volatile oils, glycosides, polysaccharides, amino acids, alkaloids and the like, wherein the coumarins mainly comprise imperatorin, isoimperatorin, oxypeucedanin, hydrated oxypeucedanin, xanthotoxol, angelica dahurica and isopsoralen, the volatile oils mainly comprise pentadecanol, dodecanol and oleyl alcohol, and 3 volatile components; glycosides mainly include aurantiamarin, isofraxidin-7-O-beta-D-glucopyranoside, benzyl-O-beta-D-glucopyranoside, scopolamine, (2 'R) -5' -hydroxy aurantiamarin-5 '-O-beta-D-glucopyranoside, (2' S,3 'R) -3' -hydroxy aurantiamarin, skimmin and the like; the polysaccharides mainly comprise 6 monosaccharides of rhamnose, arabinose, xylose, mannose, glucose and galactose; amino acids: the content of arginine in the non-essential amino acids is highest, the content of leucine in the essential amino acids is highest, and alkaloids mainly comprise desmodium styracifolium alkali, angelicine A-F and the like. The pharmacological action of the product is as follows: 1. anti-inflammatory action: the angelica dahurica can treat acne by acting on interleukin, metalloprotease tissue inhibitory factor, serum insulin-like growth factor and androgen receptor target, and interferes phosphatidylinositol-3-kinase/serine protein kinase, nuclear factor kappa B, mitogen activated protein kinase and fibroblast growth factor receptor 2 signal channel, thereby mediating processes of organism inflammatory reaction, immune reaction, sebum secretion and the like; 2. the analgesic effect is as follows: the angelica dahurica coumarin components imperatorin and isoimperatorin can be combined with receptors such as 5-hydroxytryptamine, acetylcholine, thromboxane-prostaglandin and the like, and can assist corydalis tuber to play an analgesic role through signal paths related to mediated spasm, inflammation and the like; 3. whitening: the angelica dahurica plays a role in whitening mainly by inhibiting the activity of tyrosinase; 4. photosensitivity: some coumarins such as bergapten in radix angelicae have the effect of activating tyrosine kinase, and the photosensitivity of radix angelicae for treating psoriasis is reported in the literature in the early years. 5. And (3) antibiosis: the radix Angelicae Dahuricae extract has inhibitory effect on Staphylococcus aureus, Staphylococcus epidermidis, Bacillus proteus, Salmonella paratyphi B, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Porphyromonas, Streptococcus anaerobicus, Gardnerella vaginalis, etc.; 6. and (3) antiallergic: more than 10 kinds of coumarin components such as oxypeucedanin, bergapten, phellopterin, etc. can inhibit histamine release, and reduce secretion of inflammatory cytokines IL-1 beta, IL-4 and TNF-alpha by inhibiting NF-kB pathway activation; 7. vasodilation, the vasodilatory activity of which is mediated by an endothelial-dependent pathway, comprising blocking extracellular calcium influx via a receptor-mediated Ca2+ channel and a voltage-dependent calcium channel; 8. and (3) tumor resistance: the radix angelicae dahuricae alcohol extract can inhibit the growth of B16F10 melanoma cells by promoting the down regulation of Matrix Metalloproteinase (MMP) activity and expression thereof and inducing a mitochondrion-mediated endogenous apoptosis pathway.

Medicated leaven:

this herb is sweet and pungent in flavor and warm in nature, and enters spleen and stomach meridians. The product has effects of invigorating spleen, regulating stomach function, resolving food stagnation, and regulating middle warmer, and has vitamin B-like effect, such as stimulating appetite, and maintaining normal digestive function. It is mainly used for treating dyspepsia, cardialgia, sunstroke, diarrhea, injury due to drinking, chest distress, infantile diarrhea, abdominal pain, diarrhea, dysphagia, and puerperal regurgitation. The main components of the product comprise volatile oil, vitamin B group, ergosterol, glycosides, amylase, protease, etc. As medicated leaven is a medicine obtained by co-fermenting a plurality of raw materials, the medicated leaven has extremely complex chemical components and low content, and the existing chemical separation means is difficult to efficiently obtain trace active substances in the medicated leaven. The pharmacological action of the product is as follows: can increase secretion of gastrin and cholinesterase, reduce NO content in serum, repair intestinal ulcer, enhance contraction effect on smooth muscle of intestine, increase beneficial bacteria population, and inhibit growth of enterobacter. The medicated leaven also contains abundant digestive enzymes, and amylase, protease, etc. are produced by decomposing fermentation matrix with special microorganism or microorganism group during fermentation process, so as to achieve the effects of invigorating stomach and promoting digestion.

Sweet wormwood herb:

being bitter and pungent in flavor and cold in nature, it enters liver and gallbladder meridians. The product has effects of clearing deficiency heat, cooling blood, removing heat by steaming, relieving summer-heat, and preventing malaria, and can be used for treating yin deficiency, fever due to yin deficiency, bone steaming, fatigue, fever due to summer-heat, malaria fever, and jaundice due to damp-heat. The main components of the product are sesquiterpene, diterpene, flavone, phenylpropionic acid, coumarin, volatile oil, etc. Sesquiterpenes: the main chemical component in sweet wormwood herb, especially artemisinin with antimalarial effect is the best known. The sesquiterpenes separated from herba Artemisiae Annuae include arteannuin, dihydrodeoxyartemisinin B, deoxyartemisinin B, and arteannuic acid. The pharmacological action of the product is as follows: 1. antimalarial effect: the mechanism of action of artemisinin compounds to exert antimalarial activity includes: (1) the peroxide bridge bond is an important part artemisinin which plays antimalarial activity, and the peroxide bridge bond is broken under the catalysis of hemoglobin Fe2+ to generate oxygen and carbon free radicals, the free radicals can block the nutrient absorption of plasmodium along with amino acid residues near the organic alkylation binding site, and meanwhile, autophagic vacuoles are quickly formed to discharge protozoa which lack nutrition and cause amino acid starvation, so that the effect of killing the plasmodium is played; (2) under the catalytic action of a certain amount of Fe2+, artemisinin generates a free radical taking carbon as a center, activated artemisinin targets and acts on calcium ATP protein 6(PfATP6) of plasmodium by virtue of a hydrophobic skeleton of the activated artemisinin, the concentration of calcium ions in cytoplasm of the plasmodium is increased, and the insecticidal and antimalarial effects are exerted. 2. The anti-tumor effect is as follows: sesquiterpene lactone and flavonoid components in Artemisia annua have good antitumor activity, and artemisinin derivatives can inhibit proliferation of cervical cancer HeLa cells in vitro and promote apoptosis. 3. Bacteriostasis and disinsection effects: the volatile oil in the sweet wormwood herb has obvious inhibiting effect on enterococcus, candida albicans and yeast, and the proposal of combining the artemisinin derivative preparation (dihydroartemisinin piperaquine phosphate tablets and sweet wormwood tiger fat tablets) and the compound sulfamethoxazole and azithromycin is an effective medicine for treating toxoplasma encephalopathy. 4. Antipyretic and anti-inflammatory effects: the sweet wormwood water extract, the ethyl acetate and the n-butyl alcohol part have obvious antipyretic and high temperature resistant functions. Artemisinin exerts an anti-inflammatory effect by modulating nuclear transcription factor- κ B (NF- κ B) and mitogen-activated protein kinase (MAPK) signaling pathways. 5. Immunoregulation effect: directly or indirectly reducing the level of serum R97-116 antibody, inhibiting the secretion of interferon gamma (IFN-gamma) and IL-17 proinflammatory factor by lymph node mononuclear cells, and the artemisinin and the derivatives thereof have better curative effect on the systemic lupus erythematosus.

Folium isatidis

Being bitter in flavor and cold in flavor, it enters liver, heart and stomach meridians. The product has effects of clearing heat, removing toxic substance, cooling blood, and stopping bleeding, and can be used for treating epidemic febrile disease, excessive heat, polydipsia, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, hematemesis, epistaxis, jaundice, dysentery, pharyngitis, aphtha, carbuncle, and pyogenic infections. The main components of the product are indole compounds, quinazolinone compounds, sinapside compounds, organic acid compounds, etc. The indole compounds all contain indigo blue and indirubin, isatin B is contained in isatis leaf, and isoindigo is contained in isatis leaf; the quinazolone compounds include 4(3H) quinazolone, 2,4(1H,2H) quinazolone and tryptanthrin; the sinaposide compounds include glucosinolate brassicae, neoglucosinolate brassicae, and glucosinolate 1-sulfo brassicae; the organic acid compounds include 1-thiocyanic acid-2-hydroxy-3-butene, anthranilic acid, benzoic acid, syringic acid, salicylic acid, palmitic acid, etc. The pharmacological actions of the product are as follows: 1. the antibacterial effect is as follows: the folium isatidis extracts (water extract, ethanol extract and n-butyl alcohol extract) have different degrees of bacteriostasis on experimental bacteria, wherein the bacteriostasis on staphylococcus aureus is most obvious. 2. The antiviral effect is as follows: the 4(3H) quinazolone in folium Isatidis has effects of inhibiting activity of influenza virus and Coxsackie virus, and inhibiting infection and proliferation of influenza A virus, Japanese encephalitis virus, mumps virus, and influenza virus. 3. Anti-endotoxin activity: the n-butanol extraction part of the dyers woad leaf can directly neutralize and degrade endotoxin, the pyrogenicity and the lethality of the endotoxin are obviously reduced, the activity strength of the antiendotoxin of the dyers woad leaf is closely related to chemical components such as organic acids, amino acids and the like contained in the dyers woad leaf, and the components directly inactivate the bacterial endotoxin, inhibit the toxic biological effect of the bacterial endotoxin or enhance the immune function of an organism to resist the invasion of the toxin so as to play a lasting and beneficial antiendotoxin effect. 4. Effects on the immune system: the folium isatidis decoction can improve the immune function by promoting the secretion of lymphocyte IL-2, and has no obvious influence on inflammatory effect and immunopathological damage caused by TNF secretion of macrophages. 5. The anticancer effect is as follows: the indirubin participates in the regulation of the metabolism of the lung cancer cells by inducing the activities of cytochrome P4501A 1 and 1B1 mRNA enzymes in MCF-7 lung cancer cells, achieves the anti-tumor effect, has stronger inhibiting effect on animal transplantation tumors, and has better curative effect on chronic granulocytic leukemia.

Compared with the prior art, the invention has the following beneficial effects:

the traditional Chinese medicine formula particle composition is used for treating acute upper respiratory infection, can obviously accelerate the relief of symptoms such as fever and the like, and promotes the recovery of diseases; the traditional Chinese medicine has the effects of clearing lung, abating fever and the like, and has reliable curative effect; the raw materials are easy to obtain, the price is low, the preparation is convenient, and the application range is wide.

The traditional Chinese medicine composition has reasonable formula, reasonable and scientific medicine compatibility, rich medicinal material sources, moderate price, convenient material taking, convenient preparation and proper differentiation. Is suitable for treating and preventing upper respiratory tract infection. Clinical research and observation show that the medicament has obvious treatment effect when used for treating acute upper respiratory tract infection.

The invention is an addition and subtraction prescription based on the Xushiyujing effect proved prescription of national medical famous physicians in Zhejiang province, and has definite curative effect through clinical application. Moreover, the medicament for treating acute upper respiratory infection has obvious clinical treatment effect by observing hundreds of patients through clinical research. The medicine of the invention is used for treating acute upper respiratory tract infection, the fever is resolved, the symptom is controlled stably, and the time can be advanced by 0-4 days from the fever to the normal body temperature. The disease is stable, and the curative effects of clearing lung and abating fever are reliable.

The traditional Chinese medicine formula particle composition can be used by combining the four diagnostic methods of traditional Chinese medicine aiming at the symptoms of patients before the definite diagnosis is made in modern medicine, has definite curative effect and has good compliance.

Drawings

FIG. 1 is a box diagram of the annealing time of each group;

figure 2 is a bar graph of the efficacy profile of each group.

Detailed Description

Selecting formula granules of 15g of fried scutellaria baicalensis, 9g of perilla leaf, 30g of folium isatidis, 9g of mint, 12g of platycodon grandiflorum, 9g of radix peucedani, 9g of bupleurum chinense, 12g of white mulberry root-bark, 12g of thunberg fritillary bulb, 15g of angelica dahurica, 15g of medicated leaven (namely charred medicated leaven), 30g of sweet wormwood, 30g of wild buckwheat and 9g of blackberry lily, uniformly mixing, and dividing into 2 bags, wherein one bag is respectively used in the morning and evening. When in use, one bag is torn off and poured into a cup, boiled water is added for brewing, and the mixture is fully stirred until being dissolved.

Partial clinical data for the treatment of acute upper respiratory infection according to the invention

Now, the effect of treating acute upper respiratory tract infection by using the traditional Chinese medicine composition of the invention is illustrated, and the detailed contents of treating patients with acute upper respiratory tract infection by using the traditional Chinese medicine formula granule composition of the invention are as follows:

the treatment subjects were: 200 patients who are out-patients with fever in 30 days 1 and 30 days 4 and 30 days 2020 are randomly divided into 50 cases of traditional Chinese medicine treatment groups (treated by the traditional Chinese medicine formula particle composition and western medicine conventional treatment) and 150 cases of conventional treatment groups (treated by western medicine conventional treatment). Treating according to the treatment scheme, and recording according to the follow-up result after treatment. Patients who were lost of visits and failed to complete the established treatment regimen were excluded, as well as misdiagnosed cases (perianal abscess 1, appendicitis 2), adverse drug reactions (levofloxacin 1). The patient data were included in total of 167 patients, 97 men and 70 women; 24 cases aged 10-19, 46 cases aged 20-29, 37 cases aged 30-39, 23 cases aged 40-49, 16 cases aged 50-59, 19 cases aged 60-79, 2 cases aged 80-89. The most common symptoms counted were fever (90.7%), cough (28.8%), nasal obstruction (20.8%), angina (20.3%), weakness (17.8%), headache (16.5%), aversion to cold (14.4%), runny nose (14.0%), dizziness (10.6%), expectoration (10.6%). Wherein, the traditional Chinese medicine treatment group comprises 38 cases and the conventional treatment group comprises 129 cases. No statistical difference was observed between the two groups in age, sex and disease (P > 005).

The treatment method comprises the following steps: the conventional treatment group carries out symptomatic treatment and basic supporting treatment such as oxygen inhalation, antivirus, anti-infection, phlegm elimination, cough relieving and the like according to the specific state of illness of a patient. The traditional Chinese medicine treatment group is taken with the traditional Chinese medicine formula particle composition on the basis of the conventional treatment scheme of the treatment group for 3-6 days.

The curative effect judgment (made according to the guiding principle of clinical research of new traditional Chinese medicine (examination) 2002, Zhengxiao cornus main edition):

and (3) healing: the body temperature returns to normal within 3 days after treatment, and the symptoms of upper respiratory tract infection disappear completely.

The effect is shown: the body temperature is normal within 3 days of treatment, and the symptoms of upper respiratory infection mostly disappear.

The method has the following advantages: the body temperature is reduced within 3 days of treatment compared with the prior treatment, and the main symptoms of the upper respiratory tract infection are partially disappeared.

And (4) invalidation: the body temperature is not reduced or increased within 3 days of treatment, and the main symptoms of upper respiratory tract infection are not improved.

Statistical treatment:and measuring the data distribution of the data by adopting t test or non-parameter statistics. Chi for counting data²And (5) checking, and selecting rank and checking the grade data. With p<0.05 indicates that the difference is statistically significant.

The treatment results are as follows:

(1) the antipyretic effect is as follows: the antipyretic time of the granule group is 0.5-3 days, and the median: 1 (0.5-1) day; the antipyretic time of the conventional treatment group is 0.5-7 days, and the median: 1 (0.5-2) day. The data are found to be in abnormal distribution by inspection, and the granules have obvious antipyretic effect by comparison of a Mann-Whitney test and have significant difference (p is less than 0.05) compared with a conventional treatment group, which is detailed in Table 1. The box chart of the annealing time of each group is shown in figure 1.

TABLE 1 comparison of antipyretic time between granule and conventional treatment groups

	Time to defervesce	Z	p
				Granules	1(0.5～1)	-2.191	0.028
General of	1(0.5～2)

(2) The treatment effect of the main symptoms is as follows:

after 167 patients included were treated, 94 (56.29%) were cured, 24 (14.37%) were significantly effective, 27 (16.17%) were effective, and 22 (13.17%) were ineffective. After comparison, the granule group is found to have better curative effect than the conventional treatment group, and has significant difference (p <0.01), which is detailed in table 2.

TABLE 2 comparison of the efficacy of the granule group with that of the conventional treatment group

Typical cases are:

1. the patient comes for diagnosis by 'pharyngalgia fever 1 day' in 3 months and 3 days in 2020, and has no obvious induction of pharyngalgia fever, poor appetite, no nasal obstruction, no headache, no cough and expectoration, no chest distress and short breath, long-term permanent health for living, no history of going out, no contact history of foreign people, no contact history of febrile people and no contact history of wild animals before 1 day. And (5) a health code green code. Physical examination: 38.9 ℃, P96/min, R22/min, BP: 120/70mmhg, clear mind, no macula on face, no obvious abnormality in flat scan of 2020.3.3 chest CT. 2020/3/3 routine blood test: 12.54 x 10^9/L white blood cells; c-reactive protein 6.00 mg/L; 75.8% of neutrophils; neutrophil count 9.5110^ 9/L; lymphocyte count 1.5810^ 9/L; lymphocyte 12.6%; 2020/3/3 influenza a virus antigen (colloidal gold method) negative; influenza b virus antigen (colloidal gold method) negative; and (3) preliminary diagnosis: acute pharyngolaryngitis and hyponatremia. The Chinese medicinal composition granules are taken for immediate transfusion, anti-infection and symptomatic treatment, and comprise the following components: 15g of fried scutellaria baicalensis, 9g of perilla leaf, 30g of folium isatidis, 9g of mint, 12g of platycodon grandiflorum, 9g of radix peucedani, 9g of bupleurum chinense, 12g of white mulberry root-bark, 12g of thunberg fritillary bulb, 15g of angelica dahurica, 15g of charred medicated leaven, 30g of sweet wormwood herb, 30g of wild buckwheat rhizome and 9g of blackberry lily. 3 doses of the traditional Chinese medicine composition are taken with water twice a day, after one day of taking, the self-induction symptom is obviously relieved, the body temperature is reduced to be normal, after three days of taking, other symptoms such as pharyngalgia and the like disappear, and the disease is cured.

2. The patient is diagnosed with 'fever 1 day' in 18 months of 4 and 2020, the patient has fever, nasal discharge and nasal obstruction, cough, headache and no muscle soreness before 1 day, and the patient is diagnosed with the disease at present without improvement of self-taking medicine. The last menstruation 2020.02.05, deny the recent poultry exposure history, deny the visit and residence history of Hubei, Wenzhou and Taizhou areas within 2 weeks, deny the visit and contact history of people in Hubei, Wenzhou and Taizhou areas within 2 weeks, deny the history of fever of people around, deny the history of leaving home within 2 weeks. Physical examination: 39.6 ℃, P98/min, R23/min, BP: 126/75mmhg, 2020/4/18 white blood cells 10.70 x 10^ 9/L; monocyte% 6.4%; 21mg/L of C-reactive protein; neutrophil% 82.5%; basophilic granulocytes% 0.2%; 2020/4/18 influenza a virus antigen (colloidal gold method) negative; influenza b virus antigen (colloidal gold method) negative; no obvious abnormalities were seen in chest CT. And (3) preliminary diagnosis: acute upper respiratory infection, immediate transfusion, anti-infection and symptomatic treatment, and the Chinese medicinal composition granules are taken to comprise the following components: 15g of fried scutellaria baicalensis, 9g of perilla leaf, 30g of folium isatidis, 9g of mint, 12g of platycodon grandiflorum, 9g of radix peucedani, 9g of bupleurum chinense, 12g of white mulberry root-bark, 12g of thunberg fritillary bulb, 15g of angelica dahurica, 15g of charred medicated leaven, 30g of sweet wormwood herb, 30g of wild buckwheat rhizome and 9g of blackberry lily. 3 doses of the traditional Chinese medicine composition are taken with water twice a day, after one day of taking, the self-induction symptom is relieved, the body temperature is reduced to be normal on the second day, and other symptoms are relieved after two or three days.

3. The patient Li is 23 years old, is diagnosed with the fever for 1 day in 14 days 4 months in 2020, has the symptoms of fever discomfort, nasal obstruction, watery nasal discharge and angina, denies recent poultry contact history, denies the visit and residence history of Hubei, Wenzhou and Taizhou areas within 2 weeks, denies the contact history of people in the Hubei, Wenzhou and Taizhou areas within 2 weeks, denies the fever history of surrounding people and denies the national history within 2 weeks. Physical examination: 38.6 ℃, P86/min, R21/min, BP: 118/78mmhg, 2020/4/14 white blood cells 10.16 x 10^ 9/L; 168g/L of hemoglobin; c-reactive protein 7 mg/L; 87.6% of neutrophils; monocyte% 3.5%; influenza a virus antigen (colloidal gold method) negative; influenza b virus antigen (colloidal gold method) negative; no obvious abnormality was seen in the chest CT flat scan. And (3) preliminary diagnosis: acute upper respiratory infection, immediate transfusion, anti-infection and symptomatic treatment, and the Chinese medicinal composition granules are taken to comprise the following components: 15g of fried scutellaria baicalensis, 9g of perilla leaf, 30g of folium isatidis, 9g of mint, 12g of platycodon grandiflorum, 9g of radix peucedani, 9g of bupleurum chinense, 12g of white mulberry root-bark, 12g of thunberg fritillary bulb, 15g of angelica dahurica, 15g of charred medicated leaven, 30g of sweet wormwood herb, 30g of wild buckwheat rhizome and 9g of blackberry lily. 3 doses of the traditional Chinese medicine composition are taken with water twice a day, after one day of taking, the symptoms are relieved, and after the third day, the body temperature symptoms and other symptoms are relieved.

4. The patient should be treated in 23 years in 7 days 4 and 7 months in 2020 because of "pharyngalgia fever 1 day", and the patient should begin to have pharyngalgia and discomfort, with subjective fever and discomfort, with cough, no phlegm, no nasal obstruction and running nose, no nausea and vomiting at 1 morning. 3.18 from Yunnan Zhenxiao self-driving. Measuring the body temperature: 39.4 ℃, breast CT: the two lungs have slightly increased texture; a little of the right upper lung and the left lower lung disperse in the affected part; please combine the clinical and follow-up visits if necessary. And (3) preliminary diagnosis: acute upper respiratory infection and pulmonary infection are instantly transfused, anti-infective and symptomatic treatment, and the Chinese medicinal composition granules are taken to comprise the following components: 15g of fried scutellaria baicalensis, 9g of perilla leaf, 30g of folium isatidis, 9g of mint, 12g of platycodon grandiflorum, 9g of radix peucedani, 9g of bupleurum chinense, 12g of white mulberry root-bark, 12g of thunberg fritillary bulb, 15g of angelica dahurica, 15g of charred medicated leaven, 30g of sweet wormwood herb, 30g of wild buckwheat rhizome and 9g of blackberry lily. 3 doses of the traditional Chinese medicine composition are taken with water twice a day, after one day of taking, the symptoms are relieved earlier, and after the third day, the body temperature symptoms and other symptoms are relieved.

5. The patient is in 35 years of age, is diagnosed with cough and fever for 1 day in 3 months and 15 days in 2020, has no obvious inducement before 1 day, has cough and fever, is accompanied with hypodynamia, is full of muscle soreness, has no obvious expectoration, has no nasal obstruction and no pharyngalgia, has no history of outgoing, no contact history of foreign people and no contact history of wild animals when living in Wuyi Tung Qin for a long time. Health code: and (4) green codes. Measuring the body temperature at 38.0 ℃, 2020/3/15 blood conventional leucocyte 14.2810^ 9/L; 17.00mg/L of C-reactive protein; 85.1% of neutrophils; neutrophil count 12.1610^ 9/L; lymphocyte 5.2%; lymphocyte count 0.7410^ 9/L; 2020/3/15 influenza a virus antigen (colloidal gold method) negative; influenza b virus antigen (colloidal gold method) negative; 2020/3/15 biochemical sodium (acute) 131.1mmol/L for emergency treatment; and (3) preliminary diagnosis: acute upper respiratory infection, immediate transfusion, anti-infection and symptomatic treatment, and the Chinese medicinal composition granules are taken to comprise the following components: 15g of fried scutellaria baicalensis, 9g of perilla leaf, 30g of folium isatidis, 9g of mint, 12g of platycodon grandiflorum, 9g of radix peucedani, 9g of bupleurum chinense, 12g of white mulberry root-bark, 12g of thunberg fritillary bulb, 15g of angelica dahurica, 15g of charred medicated leaven, 30g of sweet wormwood herb, 30g of wild buckwheat rhizome and 9g of blackberry lily. 3 doses of the traditional Chinese medicine composition are taken with water twice a day, after one dose of the traditional Chinese medicine composition is taken, a patient feels that symptoms are obviously improved, the body temperature is normal on the day, and other symptoms are relieved.

The lung-clearing and fever-abating traditional Chinese medicine comprises the following components in parts by weight: 15-30 parts of wild buckwheat rhizome, 9-15 parts of fried scutellaria baicalensis, 4-9 parts of perilla leaf, 4-9 parts of mint, 4-9 parts of bupleurum chinense, 15-30 parts of sweet wormwood herb and 15-30 parts of folium isatidis. The traditional Chinese medicine composition is used for treating acute upper respiratory tract infection, can obviously accelerate the relief of fever symptoms, and effectively treats various common symptoms caused by the upper respiratory tract infection. The medicine has reliable curative effect of clearing lung and abating fever, is easy to obtain materials, low in price, convenient to obtain and wide in application range. Through years of research, hundreds of patients are clinically observed, and the clinical treatment effect is obvious. When the medicine is used for treating acute upper respiratory infection, the fever is quickly resolved, and the time is advanced by 0-4 days from fever to normal body temperature. Other upper respiratory tract infection symptoms are steadily resolved, and the curative effect is obvious compared with other treatment groups.

Claims (6)

1. A traditional Chinese medicine for clearing lung and abating fever is characterized in that: the raw materials of the traditional Chinese medicine for clearing lung and bringing down fever comprise, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of fried scutellaria baicalensis, 4-9 parts of perilla leaf, 4-9 parts of mint, 4-9 parts of bupleurum chinense, 15-30 parts of sweet wormwood herb and 15-30 parts of folium isatidis.

2. A traditional Chinese medicine for clearing lung and abating fever is characterized in that: the traditional Chinese medicine for clearing lung and bringing down fever comprises, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of fried scutellaria baicalensis, 4-9 parts of perilla leaf, 4-9 parts of mint, 4-9 parts of bupleurum chinense, 15-30 parts of sweet wormwood herb, 15-30 parts of folium isatidis, 4-9 parts of blackberry lily, 4-12 parts of platycodon grandiflorum, 4-12 parts of cortex mori and 4-12 parts of thunberg fritillary bulb.

3. A traditional Chinese medicine for clearing lung and abating fever is characterized in that: the raw materials of the traditional Chinese medicine for clearing lung and bringing down fever comprise, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of fried scutellaria baicalensis, 4-9 parts of perilla leaf, 4-9 parts of mint, 4-9 parts of bupleurum chinense, 15-30 parts of sweet wormwood, 15-30 parts of folium isatidis and 4-15 parts of angelica dahurica.

4. A traditional Chinese medicine for clearing lung and abating fever is characterized in that: the raw materials of the traditional Chinese medicine for clearing lung and bringing down fever comprise, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of fried scutellaria baicalensis, 4-9 parts of perilla leaf, 4-9 parts of mint, 4-9 parts of bupleurum chinense, 15-30 parts of sweet wormwood, 15-30 parts of folium isatidis and 9-15 parts of medicated leaven.

5. A traditional Chinese medicine for clearing lung and abating fever is characterized in that: the raw materials of the traditional Chinese medicine composition comprise, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of fried scutellaria baicalensis, 4-9 parts of perilla leaf, 4-9 parts of mint, 4-9 parts of radix peucedani, 4-9 parts of bupleurum chinense, 15-30 parts of sweet wormwood herb, 15-30 parts of folium isatidis, 4-9 parts of blackberry lily, 4-12 parts of platycodon grandiflorum, 4-12 parts of cortex mori, 4-12 parts of thunberg fritillary bulb, 4-15 parts of radix angelicae and 9-15 parts of medicated leaven.

6. The use of the lung-clearing and fever-abating traditional Chinese medicine according to any one of claims 1 to 5 in the preparation of a medicament for treating acute upper respiratory tract infection.

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