CN113080546A - 一种治疗和/或预防鼻炎的口罩及其制备方法 - Google Patents
一种治疗和/或预防鼻炎的口罩及其制备方法 Download PDFInfo
- Publication number
- CN113080546A CN113080546A CN202110345927.9A CN202110345927A CN113080546A CN 113080546 A CN113080546 A CN 113080546A CN 202110345927 A CN202110345927 A CN 202110345927A CN 113080546 A CN113080546 A CN 113080546A
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- parts
- mask
- traditional chinese
- chinese medicine
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Abstract
本发明属于口罩领域,具体的涉及一种治疗和/或预防鼻炎的口罩及其制备方法。本发明的口罩包括口罩本体和中药插片,所述口罩本体的内侧或外侧上设有所述中药插片,其中:以重量份计,所述中药插片包括苍耳子5‑7重量份、辛夷4‑8重量份、薄荷6‑10重量份、白芷5‑8重量份、黄芩4‑8重量份、栀子5‑8重量份、柴胡4‑7重量份、细辛1‑3重量份、川芎5‑7重量份、黄芪12‑16重量份、川木通4‑7重量份、桔梗4‑8重量份和茯苓7‑10重量份。本发明的中药插片能够有效的治疗鼻炎,设置在口罩内侧或者外侧时,消费者在佩戴口罩的时候,通过呼吸能够让中药插片散发的药液进入到患者的鼻腔内,从而有效的能够对鼻炎进行治疗和/或预防。
Description
技术领域
本发明属于口罩领域,具体的涉及一种治疗和/或预防鼻炎的口罩及其制备方法。
背景技术
口罩是一种卫生用品,一般指戴在口鼻部位用于过滤进入口鼻的空气,以达到阻挡有害的气体、气味、飞沫、病毒等物质的作用,以纱布或纸等材料做成。口罩对进入肺部的空气有一定的过滤作用,在呼吸道传染病流行时,在粉尘等污染的环境中作业时,戴口罩具有非常好的作用。口罩可分为空气过滤式口罩和供气式口罩。
已有的由多层纱布缝制的普通口罩,主要用于医院或空气污染环境处,以防止疾病传播,起到了一定的疗效,阻止了病员直接呼出的部分病毒病菌进入人体,降低了呼吸道传染病的发生。
但是现有的普通口罩由于仅仅具有过滤空气的作用,导致其现有的普通口罩很难有效的治疗和/或预防鼻炎。
发明内容
本发明为了解决上述背景技术中现有的普通口罩由于仅仅具有过滤空气的作用,导致其现有的普通口罩很难有效的治疗和/或预防鼻炎的技术问题,提供一种治疗和/或预防鼻炎的口罩。
本发明采用的技术方案如下:
本发明一方面提供了一种治疗和/或预防鼻炎的口罩,包括口罩本体和中药插片,所述口罩本体的内侧或外侧上设有所述中药插片,其中:
以重量份计,所述中药插片包括苍耳子5-7重量份、辛夷4-8重量份、薄荷6-10重量份、白芷5-8重量份、黄芩4-8重量份、栀子5-8重量份、柴胡4-7重量份、细辛1-3重量份、川芎5-7重量份、黄芪12-16重量份、川木通4-7重量份、桔梗4-8重量份和茯苓7-10重量份。
本发明的有益效果是:本发明的中药插片能够有效的治疗鼻炎,设置在口罩内侧或者外侧时,消费者在佩戴口罩的时候,通过呼吸能够让中药插片散发的药液进入到患者的鼻腔内。从而有效的能够对鼻炎进行治疗和/或预防。解决了现有的普通口罩由于仅仅具有过滤空气的作用,导致其现有的普通口罩很难有效的治疗和/或预防鼻炎的技术问题。
在上述技术方案的基础上,本发明还可以做如下改进。
进一步,所述中药插片包括苍耳子5.5-6.5重量份、辛夷5-6重量份、薄荷8-9重量份、白芷6-7重量份、黄芩5-6重量份、栀子6-7重量份、柴胡5.5-6重量份、细辛1-2重量份、川芎6-7重量份、黄芪14-15重量份、川木通5-6重量份、桔梗5-6重量份、茯苓8-9重量份。
采用上述进一步方案的有益效果是,上述成分比例的中药插片,能够起到更好的治疗鼻炎的效果。
进一步,所述中药插片还包括缓控释基体。
采用上述进一步方案的有益效果是,通过加入缓控释基体,能够延缓气味的散发,使得口罩能够拥有更持久的治疗或预防鼻炎的效果。
进一步,以重量份计,所述缓控释基体包括桃胶5~7重量份,甘油5~7重量份,粉状硅胶3~5重量份,聚丙烯酸钠3~5重量份,活性炭1~2重量份,甘羟铝2~3重量份和二氧化钛1~2重量份。优选的,所述缓控释基体还包括西黄蓍胶8~10重量份。
采用上述进一步方案的有益效果是,西黄蓍胶的粘性较大,但乳化能力差,因此与桃胶配合使用,再与聚丙烯酸钠相结合,使得缓控释基体粘度适中且久存粘度变化极小,易剥离、不易腐败;甘油为最常用的保湿剂,能与水以任意比例互溶,不仅保湿滋润效果好,还温和不刺激;由于聚丙烯酸钠为直链共聚物,需用Al3+与之交联,故选用甘羟铝作为交联剂;粉状硅胶作为填充剂;氮酮为促渗剂,促进药物有效成分的释放;基体中加入功能性粒子活性炭和二氧化钛,可以吸附病毒颗粒,并在光催化作用下使其分解,与本发明中的药性材料相互协同,加强了抗病毒作用。与本发明的中药插片内的鼻渊舒13味中药的相应比例的配合,既能保证形成有效的病毒滤过屏障,又能延长抗病毒的防护作用时间,才能使赋形性、粘附力等相应指标符合质量标准规定,柔软度适中。其他配比外的组合,对产品的质量造成很不好的影响。
另一方面,本发明还提供了一种治疗和/或预防鼻炎的口罩,包括口罩本体、储药袋和中药插片,其中:
所述口罩本体的外侧或内测设有储药袋;
所述储药袋仅有一处开口,所述储药袋的开口端设有用于打开或闭合所述开口的魔术贴;
所述中药插片能够通过所述储药袋的开口进出所述储药袋。
本发明的有益效果是,储药袋将中药插片与患者隔开且储药袋设置在口罩本体的两侧。所以不但减少了中药插片受到环境的干扰而造成的污染,而且能够提升中药插片对于消费者的鼻炎的治疗效果。
在上述技术方案的基础上,本发明还可以做如下改进。
进一步,所述储药袋设置在所述口罩本体的内侧。
采用上述进一步方案的有益效果是,设置在内侧能够提升中药插片的治疗或预防鼻炎的效果。
进一步,所述储药袋上设有若干个排气孔。
采用上述进一步方案的有益效果是,排气孔能够有效增强中药插片与使用者之间的空气流通,有利于提升疗效。
进一步,所述储药袋采用吸湿发热纤维制成。
采用上述进一步方案的有益效果是,由于储药袋采用的吸湿发热纤维制成,所以使用者在佩戴口罩后的呼吸过程中,由于呼出热气,使得储药袋发热,从而让中药插片发热,大大的提升了药效。
另一方面,本发明还提供了一种如上所述的治疗和/或预防鼻炎的口罩的制备方法,首先取口罩本体,接着将储药袋缝合在所述口罩本体的内侧,接着将中药插片从所述储药袋的开口放入所述储药袋内,最后魔术贴封闭所述储药袋的开口,得到治疗和/或预防鼻炎的口罩。
本发明的有益效果是,本发明的口罩的制作工艺方便快捷,能够有效的实现本发明要解决的技术问题。
在上述技术方案的基础上,本发明还可以做如下改进。
进一步,所述中药插片的制备步骤如下:
S1、将辛夷、苍耳子、薄荷、白芷、栀子、柴胡、细辛、川芎、黄芪、川木通、桔梗和茯苓按照上述配比加水进行至少一次蒸馏,收集蒸馏液和药渣;
S2、将步骤S1的所述药渣依次进行煎煮和浓缩后加入乙醇使得醇含量达到67~74wt%,接着浓缩后得到醇浸膏;
S3、将上述配比的黄芩加水进行煎煮并浓缩后,调节pH至1.5~2,得到黄芩沉淀;
S4、将步骤S1中的蒸馏液、步骤S2中的醇浸膏和步骤S3中的黄芩沉淀混合,得到提取药液;
S5、将桃胶、西黄蓍胶和蒸馏水混合搅拌,并达到溶胀状态,得第一混合物;
S6、在水浴条件下将聚丙烯酸钠和蒸馏水混合搅拌,使其充分溶胀,得第二混合物;
S7、将第一混合物和第二混合物混合,并在水浴条件下加热搅拌至完全溶解,得第三混合物;
S8、将粉状硅胶、活性炭、二氧化钛、氮酮和第三混合物相混合,并在水浴条件下加热搅拌均匀,得第四混合物;用甘油将甘羟铝分散均匀,并与所述第四混合物混合搅拌均匀,即得缓控释基体;
S9、将缓控释基体与步骤S4的提取药液混合均匀后在水浴条件下加热,并不断搅拌炼合至浓溶状态,最后依次经过衬布涂布、干燥、贴防粘膜和切片,即得中药插片。
采用上述进一步方案的有益效果是,通过上述的制备步骤,能够很好的制造得到中药插片。由于中药插片的表明涂抹了混合并且浓溶得到缓控释基体和提取药液,使得提取药液的成分能够缓慢的挥发出来进入到使用者的鼻腔中,从而达到治疗或预防鼻炎的效果。
附图说明
图1为本发明口罩的正视图;
图2为本发明口罩的侧视图;
图3为本发明口罩的后视图;
图4为本发明图3的***图;
图5为本发明的折线图;
附图中,各标号所代表的部件列表如下:
1、口罩本体,2、储药袋,201、排气孔,202、魔术贴,3、中药插片
具体实施方式
以下结合附图对本发明的原理和特征进行描述,所举实例只用于解释本发明,并非用于限定本发明的范围。
实施例1、
如图1至图4所示,一种治疗和/或预防鼻炎的口罩的制备方法,首先取口罩本体1,接着将储药袋2缝合在所述口罩本体1的内侧,接着将中药插片3从所述储药袋2的开口放入所述储药袋2内,最后魔术贴202封闭所述储药袋2的开口,得到治疗和/或预防鼻炎的口罩。其中:
所述中药插片3的制备步骤如下:
S1、将500g辛夷、400g苍耳子、600g薄荷、500g白芷、500g栀子、400g柴胡、100g细辛、500g川芎、1200g黄芪、400g川木通、400g桔梗和700g茯苓按照上述配比加水进行至少一次蒸馏,收集蒸馏液和药渣;
S2、将步骤S1的所述药渣依次进行煎煮和浓缩后加入乙醇使得醇含量达到67~74wt%,接着浓缩后得到醇浸膏;
S3、将上述配比的400g黄芩加水进行煎煮并浓缩后,调节pH至1.5~2,得到黄芩沉淀;
S4、将步骤S1中的蒸馏液、步骤S2中的醇浸膏和步骤S3中的黄芩沉淀混合,得到提取药液;
S5、将500g桃胶、800g西黄蓍胶和蒸馏水混合搅拌2min,并达到溶胀状态,得第一混合物;其中,加入的蒸馏水的体积是桃胶和西黄蓍胶总体积的20倍;
S6、在水浴条件下将300g聚丙烯酸钠和蒸馏水混合搅拌,使其充分溶胀,得第二混合物;其中,加入的蒸馏水的体积是聚丙烯酸钠的10倍;
S7、将第一混合物和第二混合物混合,并在40℃水浴条件下加热搅拌至完全溶解,搅拌的速率为10r/min,搅拌的时间为2min,得第三混合物;
S8、将300g粉状硅胶、100g活性炭、100g二氧化钛、200g氮酮和第三混合物相混合,并在50℃水浴条件下加热搅拌均匀,得第四混合物;用500g甘油将200g甘羟铝分散均匀,并与所述第四混合物混合搅拌均匀,即得缓控释基体;
S9、将缓控释基体与步骤S4的提取药液混合均匀后在水浴条件下加热,并不断搅拌炼合至浓溶状态,最后依次经过在45℃下衬布涂布、于35℃下真空干燥3h、贴聚丙烯防粘膜和切片成14X10cm2,即得中药插片3。
实施例2、
与实施例1的区别在于,苍耳子为700g,辛夷为400g,薄荷为600g,白芷为500g,栀子为500g,柴胡为400g,细辛为300g,川芎为700g,黄芪为1600g,川木通为700g,桔梗为800g,茯苓为1000g,黄芩为800g,桃胶为700g,西黄蓍胶为1000g,聚丙烯酸钠为500g,粉状硅胶为500g,活性炭为200g,二氧化钛为200g,氮酮为300g,甘油为700g,甘羟铝为300g。
实施例3、
与实施例1的区别在于,苍耳子为550g,辛夷为500g,薄荷为800g,白芷为600g,栀子为600g,柴胡为550g,细辛为100g,川芎为600g,黄芪为1400g,川木通为500g,桔梗为500g,茯苓为800g,黄芩为500g,桃胶为600g,西黄蓍胶为850g,聚丙烯酸钠为400g,粉状硅胶为320g,活性炭为130g,二氧化钛为150g,氮酮为240g,甘油为600g,甘羟铝为260g。
实施例4、
与实施例1的区别在于,苍耳子为650g,辛夷为600g,薄荷为900g,白芷为700g,栀子为700g,柴胡为600g,细辛为200g,川芎为700g,黄芪为1500g,川木通为600g,桔梗为600g,茯苓为900g,黄芩为600g,桃胶为600g,西黄蓍胶为850g,聚丙烯酸钠为400g,粉状硅胶为320g,活性炭为130g,二氧化钛为150g,氮酮为240g,甘油为600g,甘羟铝为260g。
实施例5、
与实施例1的区别在于,苍耳子为600g,辛夷为550g,薄荷为850g,白芷为650g,栀子为650g,柴胡为580g,细辛为150g,川芎为650g,黄芪为1450g,川木通为550g,桔梗为550g,茯苓为850g,黄芩为550g,桃胶为600g,西黄蓍胶为850g,聚丙烯酸钠为400g,粉状硅胶为320g,活性炭为130g,二氧化钛为150g,氮酮为240g,甘油为600g,甘羟铝为260g。
对比文件1、
与实施例1的区别在于,不包含桃胶。
对比文件2、
与实施例1的区别在于,桃胶为400g。
对比文件3、
与实施例1的区别在于,桃胶为800g。
一、验证实验
为了说明本发明的技术效果,特做如下验证实验:
1、赋形性实验
按照《中国药典》试验方法,取按照实施例1~5和对比例1~3所述的中药插片3,置于37℃、相对湿度64%的恒温恒湿箱中30min,取出后将供试品固定在一平整的钢板上,钢板与水平面的斜角为60°,放置24h,观察中药插片3体面有无流淌现象,无流淌现象即为合格。具体的观察结果如下表1:
表1
从表1可以看出,本发明的中药插片3的赋形性良好,有利于提升本发明的口罩的质量。
2、粘附性测定
取实施例1~5和对比例1~3获得的治疗和/或预防鼻炎的口罩,轻按压实中药插片3,2min后180°剥离,观察口罩表面是否有膏体残留。具体的测试结果如下表2:
表2
从表2可以看出,本发明的口罩的膏体残留性好。能够在更换中药插片3的时候减少药品交叉,从而提升药效。
3、释放率测定
分别取实施例1至实施例5和对比例1至对比例3获得的中药插片3,以黄芩苷为指标,采用高效液相法进行含量测定,选用垂直式改良的Franz扩散池,以无纺布为释放膜,在24h内每经2h取样一次,对指标成分进行含量测定,根据如下公式计算累计释放率Q(%):Q(%)=Qt/W×100%(Qt:t时间内指标成分的单位面积累计释放量;W:制剂中各指标成分的含量),以时间为横坐标,累计释放率为纵坐标绘制Q-t曲线,结果如图5所示。具体的数据如下表3
表3
实施例1 | 实施例2 | 实施例3 | 实施例4 | 实施例5 | 对比例1 | 对比例2 | 对比例3 | |
5min | 9% | 10% | 6% | 8% | 9% | 18% | 14% | 15% |
10min | 23% | 22% | 18% | 22% | 22% | 35% | 30% | 29% |
15min | 38% | 39% | 31% | 37% | 38% | 45% | 40% | 41% |
20min | 46% | 47% | 40% | 44% | 45% | 56% | 50% | 51% |
25min | 50% | 51% | 46% | 48% | 49% | 64% | 55% | 54% |
30min | 60% | 63% | 55% | 59% | 58% | 70% | 66% | 67% |
35min | 68% | 70% | 61% | 67% | 66% | 78% | 72% | 71% |
通过上述表3中的释放率的测定可以知道,本发明的缓控释基体能够极大的延长了中药插片的味道散发时间,从而促进了鼻炎的治疗和提升了治疗效率。其中实施例3的效果最好,且本发明的组合物在配比范围内的释放率要比在配比范围外的组合物好,具有意想不到的技术效果。
4、疗效测定实验
4.1、测定方法
选有鼻炎症状的20~45岁的志愿者192例,随机分为对照组、空白组、实施例3组、实施例4组、对比例1组和对比例2组,每组32例。其中:
对照组给予氯雷他定片治疗,1片(10mg)/次,1次/天。治疗2周。
空白组,不做其他任何处理,保持2周。
实施例3组制备的一种治疗和/或预防鼻炎的口罩,45min/次,2次/天,治疗2周。
实施例4组制备的一种治疗和/或预防鼻炎的口罩,45min/次,2次/天,治疗2周。
对比例1组制备的一种治疗和/或预防鼻炎的口罩,45min/次,2次/天,治疗2周。
对比例2组制备的一种治疗和/或预防鼻炎的口罩,45min/次,2次/天,治疗2周。
比较以上6组的鼻炎大量水样鼻涕、阵发性喷嚏、鼻塞、鼻痒改善时间。根据疗效判定标准进行统计和评价。
4.2、疗效判定标准
显效:大量水样鼻涕、阵发性喷嚏、鼻塞、鼻痒等症状体征消失;
有效:大量水样鼻涕、阵发性喷嚏、鼻塞、鼻痒改善;
无效:大量水样鼻涕、阵发性喷嚏、鼻塞、鼻痒无缓解。
采用SPSS 22.0软件进行统计学分析。
4.3、疗效评价结果
6组治疗过程未见不良反应。具体的评价结果如下表4:
表4
从上述表4中的数据可以得知,可见本发明的口罩能够有效的治疗或预防鼻炎,差异具有统计学意义(P<0.05)。其中实施例3对鼻炎的治疗效果最好。
在本说明书的描述中,术语“一个实施例”、“一些实施例”、“具体实施例”等的描述意指结合该实施例或示例描述的具体特征、结构、材料或特点包含于本发明的至少一个实施例或示例中。在本说明书中,对上述术语的示意性表述不一定指的是相同的实施例或实例。而且,描述的具体特征、结构、材料或特点可以在任何的一个或多个实施例或示例中以合适的方式结合。
以上所述仅为本发明的较佳实施例,并不用以限制本发明,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (10)
1.一种治疗和/或预防鼻炎的口罩,其特征在于,包括口罩本体(1)和中药插片(3),所述口罩本体(1)的内侧或外侧上设有所述中药插片(3),其中:
以重量份计,所述中药插片(3)包括苍耳子5-7重量份、辛夷4-8重量份、薄荷6-10重量份、白芷5-8重量份、黄芩4-8重量份、栀子5-8重量份、柴胡4-7重量份、细辛1-3重量份、川芎5-7重量份、黄芪12-16重量份、川木通4-7重量份、桔梗4-8重量份和茯苓7-10重量份。
2.根据权利要求1所述的治疗和/或预防鼻炎的口罩,其特征在于,所述中药插片(3)包括苍耳子5.5-6.5重量份、辛夷5-6重量份、薄荷8-9重量份、白芷6-7重量份、黄芩5-6重量份、栀子6-7重量份、柴胡5.5-6重量份、细辛1-2重量份、川芎6-7重量份、黄芪14-15重量份、川木通5-6重量份、桔梗5-6重量份、茯苓8-9重量份。
3.根据权利要求1或2任意一项所述的治疗和/或预防鼻炎的口罩,其特征在于,所述中药插片(3)还包括缓控释基体。
4.根据权利要求3所述的治疗和/或预防鼻炎的口罩,其特征在于,以重量份计,所述缓控释基体包括桃胶5~7重量份,西黄蓍胶8~10重量份,甘油5~7重量份,粉状硅胶3~5重量份,聚丙烯酸钠3~5重量份,活性炭1~2重量份,甘羟铝2~3重量份,二氧化钛1~2重量份和氮酮2~3重量份。
5.一种治疗和/或预防鼻炎的口罩,其特征在于,包括口罩本体(1)、储药袋(2)和中药插片(3),其中:
所述口罩本体(1)的外侧或内测设有储药袋(2);
所述储药袋(2)仅有一处开口,所述储药袋(2)的开口端设有用于打开或闭合所述开口的魔术贴(202);
所述中药插片(3)能够通过所述储药袋(2)的开口进出所述储药袋(2)。
6.根据权利要求5所述的治疗和/或预防鼻炎的口罩,其特征在于,所述储药袋(2)设置在所述口罩本体(1)的内侧。
7.根据权利要求6所述的治疗和/或预防鼻炎的口罩,其特征在于,所述储药袋(2)上设有若干个排气孔(201)。
8.根据权利要求5至7任意一项所述的治疗和/或预防鼻炎的口罩,其特征在于,所述储药袋(2)采用吸湿发热纤维制成。
9.一种如权利要求1至8任意一项所述的治疗和/或预防鼻炎的口罩的制备方法,其特征在于,首先取口罩本体(1),接着将储药袋(2)缝合在所述口罩本体(1)的内侧,接着将中药插片(3)从所述储药袋(2)的开口放入所述储药袋(2)内,最后魔术贴(202)封闭所述储药袋(2)的开口,得到治疗和/或预防鼻炎的口罩。
10.根据权利要求9所述的治疗和/或预防鼻炎的口罩的制备方法,其特征在于,所述中药插片(3)的制备步骤如下:
S1、将辛夷、苍耳子、薄荷、白芷、栀子、柴胡、细辛、川芎、黄芪、川木通、桔梗和茯苓按照上述配比加水进行至少一次蒸馏,收集蒸馏液和药渣;
S2、将步骤S1的所述药渣依次进行煎煮和浓缩后加入乙醇使得醇含量达到67~74wt%,接着浓缩后得到醇浸膏;
S3、将上述配比的黄芩加水进行煎煮并浓缩后,调节pH至1.5~2,得到黄芩沉淀;
S4、将步骤S1中的蒸馏液、步骤S2中的醇浸膏和步骤S3中的黄芩沉淀混合,得到提取药液;
S5、将桃胶、西黄蓍胶和蒸馏水混合搅拌,并达到溶胀状态,得第一混合物;
S6、在水浴条件下将聚丙烯酸钠和蒸馏水混合搅拌,使其充分溶胀,得第二混合物;
S7、将第一混合物和第二混合物混合,并在水浴条件下加热搅拌至完全溶解,得第三混合物;
S8、将粉状硅胶、活性炭、二氧化钛、氮酮和第三混合物相混合,并在水浴条件下加热搅拌均匀,得第四混合物;用甘油将甘羟铝分散均匀,并与所述第四混合物混合搅拌均匀,即得缓控释基体;
S9、将缓控释基体与步骤S4的提取药液混合均匀后在水浴条件下加热,并不断搅拌炼合至浓溶状态,最后依次经过衬布涂布、干燥、贴防粘膜和切片,即得中药插片(3)。
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