CN113080202A - Long-acting silyl nano antibacterial agent and preparation method thereof - Google Patents

Long-acting silyl nano antibacterial agent and preparation method thereof Download PDF

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CN113080202A
CN113080202A CN202110391006.6A CN202110391006A CN113080202A CN 113080202 A CN113080202 A CN 113080202A CN 202110391006 A CN202110391006 A CN 202110391006A CN 113080202 A CN113080202 A CN 113080202A
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finished product
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周鲁帝
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Zhongke Weikang Shenzhen Biotechnology Co ltd
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Zhongke Weikang Shenzhen Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D183/00—Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon only; Coating compositions based on derivatives of such polymers
    • C09D183/04—Polysiloxanes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
    • C09D7/40—Additives
    • C09D7/60—Additives non-macromolecular
    • C09D7/61—Additives non-macromolecular inorganic
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
    • C09D7/40—Additives
    • C09D7/60—Additives non-macromolecular
    • C09D7/63—Additives non-macromolecular organic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
    • C08K3/20—Oxides; Hydroxides
    • C08K3/22—Oxides; Hydroxides of metals
    • C08K2003/2237—Oxides; Hydroxides of metals of titanium
    • C08K2003/2241—Titanium dioxide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
    • C08K3/20—Oxides; Hydroxides
    • C08K3/22—Oxides; Hydroxides of metals
    • C08K2003/2296—Oxides; Hydroxides of metals of zinc
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K2201/00—Specific properties of additives
    • C08K2201/011—Nanostructured additives

Abstract

The invention discloses a long-acting silyl nano antibacterial agent and a preparation method thereof in the field of antibacterial agents, wherein the long-acting silyl nano antibacterial agent is prepared from the following raw materials: trialkoxysilyl, nano titanium dioxide, nano silicon dioxide, nano zinc oxide, nano silicate, a silane coupling agent, ethanol, toluene and an activating agent. According to the invention, through adopting trialkoxysilyl and silane coupling agent, the anti-adhesion performance among nano titanium dioxide, nano silicon dioxide, nano zinc oxide and nano silicate can be improved, the water resistance and weather resistance of the antibacterial agent can be enhanced, the product can be almost suitable for the surface of any object, and the antibacterial protective layer can be effectively formed to kill viruses and bacteria for 90 days.

Description

Long-acting silyl nano antibacterial agent and preparation method thereof
Technical Field
The invention relates to the field of antibacterial agents, in particular to a long-acting silyl nano antibacterial agent and a preparation method thereof.
Background
The antibacterial agent is a medicament for preventing and treating plant diseases caused by various pathogenic microorganisms. An agent which kills or inhibits the growth of pathogenic microorganisms without interfering with the normal growth of plants. Fungicides can be classified according to mode of action, source of raw material and chemical composition. Internationally, they are generally referred to as agents for controlling various types of pathogenic microorganisms. Along with the development of bactericides, virucides, algicides and other subclasses are distinguished.
With the rapid development of nanotechnology, new ways for efficiently eliminating extracellular and intracellular pathogenic bacteria slowly appear in the public, and some novel nanomaterials such as widely researched nanogold, nanosilver, graphene oxide and the like have excellent performance in the aspect of antibacterial application and well avoid the problem of drug resistance, so that nanotechnology has huge potential in antibacterial material design and can be used for improving the sensitivity of bacteria to antibiotics. Accordingly, one skilled in the art has provided a long-acting silane-based nano antibacterial agent and a method for preparing the same to solve the problems set forth in the background art as described above.
Disclosure of Invention
The invention aims to provide a long-acting silane-based nano antibacterial agent and a preparation method thereof, which aim to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
a long-acting silyl nano antibacterial agent is prepared from the following raw materials: trialkoxysilyl, nanometer titanium dioxide, nanometer silicon dioxide, nanometer zinc oxide, nanometer silicate, silane coupling agent, ethanol, toluene and activating agent, wherein the weight parts of the raw materials are as follows: 50-60 parts of trialkoxysilyl, 50-60 parts of nano titanium dioxide, 50-60 parts of nano silicon dioxide, 50-60 parts of nano zinc oxide, 50-60 parts of nano silicate, 10-20 parts of silane coupling agent, 100 parts of ethanol, 10-20 parts of toluene and 5-10 parts of activating agent.
Wherein the silane coupling agent can be silane coupling agent kh-560 of Nanjing Quanxi chemical Co., Ltd
As a further scheme of the invention: the particle sizes of the nano titanium dioxide, the nano silicon dioxide, the nano zinc oxide and the nano silicate are all 100-200 nm.
As a still further scheme of the invention: the activating agent is any one of 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride or N-hydroxysuccinimide.
As a still further scheme of the invention: the ethanol is absolute ethanol.
A method for preparing the long-acting silane-based nano antibacterial agent, which comprises the following steps:
s1: before feeding, cleaning and sterilizing a liquid washing pot, an electronic scale, a weighing bottle, a filling machine and a packaging machine, and checking whether the names of the raw materials are correct or not;
s2: when weighing the materials, after determining that the names of the raw materials are correct, checking whether the required raw materials are complete and sufficient according to a feeding list, and finally weighing and taking the materials according to the proportion of the feeding amount of the raw materials for later use;
s3: after the bottom valve of the liquid washing pot is confirmed to be closed, putting the weighed trialkoxysilyl, nano titanium dioxide, nano silicon dioxide, nano zinc oxide, nano silicate, silane coupling agent, ethanol, toluene and activating agent into the liquid washing pot in sequence, and then stirring for 20-30min at the rotating speed of 30r/min to obtain a semi-finished product;
s4: sampling and detecting the semi-finished product, and filtering and discharging the qualified semi-finished product by using 500-mesh filter cloth;
s5: standing the discharged semi-finished product for 24 hours, and sampling and detecting the semi-finished product again to obtain a qualified semi-finished product for later use;
s6: taking the packaging material, sending the unpacked packaging material to a packaging material disinfection room for disinfection for more than 45min, carrying out first inspection on the qualified semi-finished product and the matched packaging material, and then conveying to a filling machine for filling;
s7: after filling, packaging and coding the product;
s8: and inspecting the packaged product, filling a finished product warehousing bill after the product is qualified, and delivering the finished product to warehouse.
As a still further scheme of the invention: in step S1, it is checked whether each raw material has a pass label, and if there is a mistake or no pass label, the feeding is prohibited.
As a still further scheme of the invention: in the step S2, the weight of the weighing bottle is removed first when the raw material is weighed, and an electronic scale with the precision of +/-0.2 g is adopted when the raw material is weighed to be less than 10g, an electronic scale with the weight of 3kg is adopted when the raw material is weighed to be 10g-3000g, and an electronic scale with the weight of 150kg is adopted when the raw material is weighed to be more than 3 kg.
As a still further scheme of the invention: in step S4, when the semi-finished sample is transparent liquid-free in appearance and has a pH of 4.0-10.0 (direct measurement), it is judged to be acceptable.
As a still further scheme of the invention: in step S5, when the semi-finished sample is transparent liquid-free in appearance and has a pH of 4.0-10.0 (direct measurement), it is judged to be acceptable.
As a still further scheme of the invention: in step S8, the test items include package labels, appearance indicators, sensory indicators, physical and chemical indicators, and hygiene indicators.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, through adopting trialkoxysilyl and silane coupling agent, the anti-adhesion performance among nano titanium dioxide, nano silicon dioxide, nano zinc oxide and nano silicate can be improved, the water resistance and weather resistance of the antibacterial agent can be enhanced, the product can be almost suitable for the surface of any object, and the antibacterial protective layer can be effectively formed to kill viruses and bacteria for 90 days.
Drawings
FIG. 1 is a flow chart of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1, a long-acting silane-based nano antibacterial agent is prepared from the following raw materials: trialkoxysilyl, nanometer titanium dioxide, nanometer silicon dioxide, nanometer zinc oxide, nanometer silicate, silane coupling agent, ethanol, toluene and activating agent, wherein the weight parts of the raw materials are as follows: 50-60 parts of trialkoxysilyl, 50-60 parts of nano titanium dioxide, 50-60 parts of nano silicon dioxide, 50-60 parts of nano zinc oxide, 50-60 parts of nano silicate, 10-20 parts of silane coupling agent, 100 parts of ethanol, 10-20 parts of toluene and 5-10 parts of activating agent.
The particle diameters of the nano titanium dioxide, the nano silicon dioxide, the nano zinc oxide and the nano silicate are all 100-200 nm.
The activating agent is any one of 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride or N-hydroxysuccinimide.
The ethanol is absolute ethanol.
A preparation method of a long-acting silane-based nano antibacterial agent comprises the following steps:
s1: before feeding, cleaning and sterilizing a liquid washing pot, an electronic scale, a weighing bottle, a filling machine and a packaging machine, and checking whether the names of the raw materials are correct or not;
s2: when weighing the materials, after determining that the names of the raw materials are correct, checking whether the required raw materials are complete and sufficient according to a feeding list, and finally weighing and taking the materials according to the proportion of the feeding amount of the raw materials for later use;
s3: after the bottom valve of the liquid washing pot is confirmed to be closed, putting the weighed trialkoxysilyl, nano titanium dioxide, nano silicon dioxide, nano zinc oxide, nano silicate, silane coupling agent, ethanol, toluene and activating agent into the liquid washing pot in sequence, and then stirring for 20-30min at the rotating speed of 30r/min to obtain a semi-finished product;
s4: sampling and detecting the semi-finished product, and filtering and discharging the qualified semi-finished product by using 500-mesh filter cloth;
s5: standing the discharged semi-finished product for 24 hours, and sampling and detecting the semi-finished product again to obtain a qualified semi-finished product for later use;
s6: taking the packaging material, delivering the unpacked packaging material to a packaging material disinfection room for disinfection for 45min, carrying out first inspection on the qualified semi-finished product and the matched packaging material, and then conveying to a filling machine for filling;
s7: after filling, packaging and coding the product;
s8: and inspecting the packaged product, filling a finished product warehousing bill after the product is qualified, and delivering the finished product to warehouse.
In step S1, it is checked whether each raw material has a pass label, and if there is a mistake or no pass label, the feeding is prohibited. In the step S2, the weight of the weighing bottle is removed first when the raw material is weighed, and an electronic scale with the precision of +/-0.2 g is adopted when the raw material is weighed to be less than 10g, an electronic scale with the weight of 3kg is adopted when the raw material is weighed to be 10g-3000g, and an electronic scale with the weight of 150kg is adopted when the raw material is weighed to be more than 3 kg. In step S4, when the semi-finished sample is transparent liquid-free in appearance and has a pH of 4.0-10.0 (direct measurement), it is judged to be acceptable. In step S5, when the semi-finished sample is transparent liquid-free in appearance and has a pH of 4.0-10.0 (direct measurement), it is judged to be acceptable. In step S8, the test items include package labels, appearance indicators, sensory indicators, physical and chemical indicators, and hygiene indicators.
Tests show that the silane-based nano coating long-acting antibacterial technology is effective after being sprayed for 90 days at a time, and the continuous sterilization rate is 99.91-99.99%.
Example 2, a long-acting silane-based nano antibacterial agent is prepared from the following raw materials: trialkoxysilyl, nanometer titanium dioxide, nanometer silicon dioxide, nanometer zinc oxide, nanometer silicate, silane coupling agent, ethanol, toluene and activating agent, wherein the weight parts of the raw materials are as follows: 52 parts of trialkoxysilyl, 52 parts of nano-titanium dioxide, 50 parts of nano-silicon dioxide, 52 parts of nano-zinc oxide, 50 parts of nano-silicate, 12 parts of silane coupling agent, 100 parts of ethanol, 12 parts of toluene and 7 parts of activating agent, wherein the particle diameters of the nano-titanium dioxide, the nano-silicon dioxide, the nano-zinc oxide and the nano-silicate are all 100 nm. The activating agent is 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride. The ethanol is absolute ethanol.
A preparation method of a long-acting silane-based nano antibacterial agent comprises the following steps: s1: before feeding, cleaning and sterilizing a liquid washing pot, an electronic scale, a weighing bottle, a filling machine and a packaging machine, and checking whether the names of the raw materials are correct or not; checking whether each raw material has a qualified label in S1, and strictly feeding the raw materials if the raw materials have errors or no qualified label; s2: when weighing the materials, after determining that the names of the raw materials are correct, checking whether the required raw materials are complete and sufficient according to a feeding list, and finally weighing and taking the materials according to the proportion of the feeding amount of the raw materials for later use; s3: after the bottom valve of the liquid washing pot is confirmed to be closed, putting the weighed trialkoxysilyl, nano titanium dioxide, nano silicon dioxide, nano zinc oxide, nano silicate, silane coupling agent, ethanol, toluene and activating agent into the liquid washing pot in sequence, and then stirring for 22min at the rotating speed of 30r/min to obtain a semi-finished product; s4: sampling and detecting the semi-finished product, and filtering and discharging the qualified semi-finished product by using 500-mesh filter cloth; in the step S4, when the appearance of the semi-finished product sample is transparent liquid-free and the PH is 4.0-10.0 (direct measurement), the semi-finished product sample is qualified; s5: standing the discharged semi-finished product for 24 hours, and sampling and detecting the semi-finished product again to obtain a qualified semi-finished product for later use; in the step S5, when the appearance of the semi-finished product sample is transparent liquid-free and the PH is 4.0-10.0 (direct measurement), the semi-finished product sample is qualified; s6: taking the packaging material, delivering the unpacked packaging material to a packaging material disinfection room for disinfection for 50min, carrying out first inspection on the qualified semi-finished product and the matched packaging material, and then conveying to a filling machine for filling; s7: after filling, packaging and coding the product; s8: inspecting the packaged product, filling a finished product warehousing bill after the product is qualified, and delivering the finished product to warehouse; in step S8, the test items include package labels, appearance indicators, sensory indicators, physical and chemical indicators, and hygiene indicators.
Tests show that the silane-based nano coating long-acting antibacterial technology is effective after being sprayed for 90 days at a time, and the continuous sterilization rate is 99.91%.
Example 3, a long-acting silane-based nano-antibacterial agent is prepared from the following raw materials: trialkoxysilyl, nanometer titanium dioxide, nanometer silicon dioxide, nanometer zinc oxide, nanometer silicate, silane coupling agent, ethanol, toluene and activating agent, wherein the weight parts of the raw materials are as follows: 55 parts of trialkoxysilyl, 50 parts of nano titanium dioxide, 60 parts of nano silicon dioxide, 55 parts of nano zinc oxide, 60 parts of nano silicate, 15 parts of silane coupling agent, 100 parts of ethanol, 15 parts of toluene and 10 parts of activating agent, wherein the particle diameters of the nano titanium dioxide, the nano silicon dioxide, the nano zinc oxide and the nano silicate are all 120nm, and the activating agent is N-hydroxysuccinimide.
A preparation method of a long-acting silane-based nano antibacterial agent comprises the following steps: s1: before feeding, cleaning and sterilizing a liquid washing pot, an electronic scale, a weighing bottle, a filling machine and a packaging machine, and checking whether the names of the raw materials are correct or not; checking whether each raw material has a qualified label in S1, and strictly feeding the raw materials if the raw materials have errors or no qualified label; s2: when weighing the materials, after determining that the names of the raw materials are correct, checking whether the required raw materials are complete and sufficient according to a feeding list, and finally weighing and taking the materials according to the proportion of the feeding amount of the raw materials for later use; in the step S2, when weighing the raw materials, the weight of the weighing bottle is removed, an electronic scale with the precision of +/-0.2 g is adopted when weighing less than 10g of raw materials, an electronic scale with the weight of 3kg is adopted when weighing 10g-3000g of raw materials, and an electronic scale with the weight of 150kg is adopted when weighing more than 3kg of raw materials; s3: after the bottom valve of the liquid washing pot is confirmed to be closed, putting the weighed trialkoxysilyl, nano titanium dioxide, nano silicon dioxide, nano zinc oxide, nano silicate, silane coupling agent, ethanol, toluene and activating agent into the liquid washing pot in sequence, and then stirring for 30min at the rotating speed of 30r/min to obtain a semi-finished product; s4: sampling and detecting the semi-finished product, and filtering and discharging the qualified semi-finished product by using 500-mesh filter cloth; in the step S4, when the appearance of the semi-finished product sample is transparent liquid-free and the PH is 4.0-10.0 (direct measurement), the semi-finished product sample is qualified; s5: standing the discharged semi-finished product for 24 hours, and sampling and detecting the semi-finished product again to obtain a qualified semi-finished product for later use; in the step S5, when the appearance of the semi-finished product sample is transparent liquid-free and the PH is 4.0-10.0 (direct measurement), the semi-finished product sample is qualified; s6: taking the packaging material, sending the unpacked packaging material to a packaging material disinfection room for disinfection for 55min, carrying out first inspection on the qualified semi-finished product and the matched packaging material, and then conveying to a filling machine for filling; s7: after filling, packaging and coding the product; s8: and inspecting the packaged product, filling a finished product warehousing bill after the product is qualified, and delivering the finished product to warehouse.
Tests show that the silane-based nano coating long-acting antibacterial technology is effective after being sprayed for 90 days at a time, and the continuous sterilization rate is 99.95%.
Example 4, a long-acting silane-based nano-antibacterial agent was prepared from the following raw materials: trialkoxysilyl, nanometer titanium dioxide, nanometer silicon dioxide, nanometer zinc oxide, nanometer silicate, silane coupling agent, ethanol, toluene and activating agent, wherein the weight parts of the raw materials are as follows: 60 parts of trialkoxysilyl, 60 parts of nano titanium dioxide, 60 parts of nano silicon dioxide, 50 parts of nano zinc oxide, 50 parts of nano silicate, 20 parts of silane coupling agent, 100 parts of ethanol, 20 parts of toluene and 10 parts of activating agent, wherein the particle diameters of the nano titanium dioxide, the nano silicon dioxide, the nano zinc oxide and the nano silicate are all 150nm, the activating agent is 1- (3-dimethylaminopropyl) -3-ethyl carbodiimide hydrochloride, and the ethanol is absolute ethanol.
A preparation method of a long-acting silane-based nano antibacterial agent comprises the following steps: s1: before feeding, cleaning and sterilizing a liquid washing pot, an electronic scale, a weighing bottle, a filling machine and a packaging machine, and checking whether the names of the raw materials are correct or not; checking whether each raw material has a qualified label in S1, and strictly feeding the raw materials if the raw materials have errors or no qualified label; s2: when weighing the materials, after determining that the names of the raw materials are correct, checking whether the required raw materials are complete and sufficient according to a feeding list, and finally weighing and taking the materials according to the proportion of the feeding amount of the raw materials for later use; in the step S2, when weighing the raw materials, the weight of the weighing bottle is removed, an electronic scale with the precision of +/-0.2 g is adopted when weighing less than 10g of raw materials, an electronic scale with the weight of 3kg is adopted when weighing 10g-3000g of raw materials, and an electronic scale with the weight of 150kg is adopted when weighing more than 3kg of raw materials; s3: after the bottom valve of the liquid washing pot is confirmed to be closed, putting the weighed trialkoxysilyl, nano titanium dioxide, nano silicon dioxide, nano zinc oxide, nano silicate, silane coupling agent, ethanol, toluene and activating agent into the liquid washing pot in sequence, and then stirring for 30min at the rotating speed of 30r/min to obtain a semi-finished product; s4: sampling and detecting the semi-finished product, and filtering and discharging the qualified semi-finished product by using 500-mesh filter cloth; in the step S4, when the appearance of the semi-finished product sample is transparent liquid-free and the PH is 4.0-10.0 (direct measurement), the semi-finished product sample is qualified; in S4, when the appearance of the semi-finished product sample is transparent liquid-free and the PH is 4.0-10.0 (direct measurement), the semi-finished product sample is qualified; s5: standing the discharged semi-finished product for 24 hours, and sampling and detecting the semi-finished product again to obtain a qualified semi-finished product for later use; in the step S5, when the appearance of the semi-finished product sample is transparent liquid-free and the PH is 4.0-10.0 (direct measurement), the semi-finished product sample is qualified; s6: taking the packaging material, delivering the unpacked packaging material to a packaging material disinfection room for disinfection for 50min, carrying out first inspection on the qualified semi-finished product and the matched packaging material, and then conveying to a filling machine for filling; s7: after filling, packaging and coding the product; s8: and inspecting the packaged product, filling a finished product warehousing bill after the product is qualified, and delivering the finished product to warehouse.
Tests show that the silane-based nano coating long-acting antibacterial technology is effective after being sprayed for 90 days at a time, and the continuous sterilization rate is 99.97%.
Example 5, a long-acting silane-based nano-antibacterial agent was prepared from the following raw materials: trialkoxysilyl, nanometer titanium dioxide, nanometer silicon dioxide, nanometer zinc oxide, nanometer silicate, silane coupling agent, ethanol, toluene and activating agent, wherein the weight parts of the raw materials are as follows: 58 parts of trialkoxysilyl, 55 parts of nano titanium dioxide, 52 parts of nano silicon dioxide, 50 parts of nano zinc oxide, 60 parts of nano silicate, 15 parts of silane coupling agent, 100 parts of ethanol, 20 parts of toluene and 10 parts of activating agent, wherein the particle diameters of the nano titanium dioxide, the nano silicon dioxide, the nano zinc oxide and the nano silicate are all 180nm, the activating agent is 1- (3-dimethylaminopropyl) -3-ethyl carbodiimide hydrochloride, and the ethanol is absolute ethanol.
A preparation method of a long-acting silane-based nano antibacterial agent comprises the following steps: s1: before feeding, cleaning and sterilizing a liquid washing pot, an electronic scale, a weighing bottle, a filling machine and a packaging machine, and checking whether the names of the raw materials are correct or not; checking whether each raw material has a qualified label in S1, and strictly feeding the raw materials if the raw materials have errors or no qualified label; s2: when weighing the materials, after determining that the names of the raw materials are correct, checking whether the required raw materials are complete and sufficient according to a feeding list, and finally weighing and taking the materials according to the proportion of the feeding amount of the raw materials for later use; in the step S2, when weighing the raw materials, the weight of the weighing bottle is removed, an electronic scale with the precision of +/-0.2 g is adopted when weighing less than 10g of raw materials, an electronic scale with the weight of 3kg is adopted when weighing 10g-3000g of raw materials, and an electronic scale with the weight of 150kg is adopted when weighing more than 3kg of raw materials; s3: after confirming that the bottom valve of the liquid washing pot is closed, putting the weighed trialkoxysilyl, nano titanium dioxide, nano silicon dioxide, nano zinc oxide, nano silicate, silane coupling agent, ethanol, toluene and activating agent into the liquid washing pot in sequence, and then stirring for 28min at the rotating speed of 30r/min to obtain a semi-finished product; s4: sampling and detecting the semi-finished product, and filtering and discharging the qualified semi-finished product by using 500-mesh filter cloth; in S4, when the appearance of the semi-finished product sample is transparent liquid-free and the PH is 4.0-10.0 (direct measurement), the semi-finished product sample is qualified; in the step S4, when the appearance of the semi-finished product sample is transparent liquid-free and the PH is 4.0-10.0 (direct measurement), the semi-finished product sample is qualified; s5: standing the discharged semi-finished product for 24 hours, and sampling and detecting the semi-finished product again to obtain a qualified semi-finished product for later use; in the step S5, when the appearance of the semi-finished product sample is transparent liquid-free and the PH is 4.0-10.0 (direct measurement), the semi-finished product sample is qualified; s6: taking the packaging material, delivering the unpacked packaging material to a packaging material disinfection room for disinfection for 60min, and carrying out first inspection on the qualified semi-finished product and the matched packaging material, and then conveying to a filling machine for filling; s7: after filling, packaging and coding the product; s8: and (4) inspecting the packaged product, filling a finished product warehousing bill after the packaged product is qualified, delivering the product to a warehouse, and inspecting items in S8, wherein the items comprise a packaging mark, an appearance index, a sensory index, a physical and chemical index and a health index.
Tests show that the silane-based nano coating long-acting antibacterial technology is effective after being sprayed for 90 days at a time, and the continuous sterilization rate is 99.99%.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (10)

1. A long-acting silane-based nanoantimicrobial agent characterized by: the feed is prepared from the following raw materials: trialkoxysilyl, nanometer titanium dioxide, nanometer silicon dioxide, nanometer zinc oxide, nanometer silicate, silane coupling agent, ethanol, toluene and activating agent, wherein the weight parts of the raw materials are as follows: 50-60 parts of trialkoxysilyl, 50-60 parts of nano titanium dioxide, 50-60 parts of nano silicon dioxide, 50-60 parts of nano zinc oxide, 50-60 parts of nano silicate, 10-20 parts of silane coupling agent, 100 parts of ethanol, 10-20 parts of toluene and 5-10 parts of activating agent.
2. The long-acting silane-based nanoantimicrobial agent of claim 1, wherein: the particle sizes of the nano titanium dioxide, the nano silicon dioxide, the nano zinc oxide and the nano silicate are all 100-200 nm.
3. The long-acting silane-based nanoantimicrobial agent of claim 1, wherein: the activating agent is any one of 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride or N-hydroxysuccinimide.
4. The long-acting silane-based nanoantimicrobial agent of claim 1, wherein: the ethanol is absolute ethanol.
5. A method of preparing a long-acting silyl nanoantimicrobial according to any of claims 1 to 4, wherein: the method comprises the following steps:
s1: before feeding, cleaning and sterilizing a liquid washing pot, an electronic scale, a weighing bottle, a filling machine and a packaging machine, and checking whether the names of the raw materials are correct or not;
s2: when weighing the materials, after determining that the names of the raw materials are correct, checking whether the required raw materials are complete and sufficient according to a feeding list, and finally weighing and taking the materials according to the proportion of the feeding amount of the raw materials for later use;
s3: after the bottom valve of the liquid washing pot is confirmed to be closed, putting the weighed trialkoxysilyl, nano titanium dioxide, nano silicon dioxide, nano zinc oxide, nano silicate, silane coupling agent, ethanol, toluene and activating agent into the liquid washing pot in sequence, and then stirring for 20-30min at the rotating speed of 30r/min to obtain a semi-finished product;
s4: sampling and detecting the semi-finished product, and filtering and discharging the qualified semi-finished product by using 500-mesh filter cloth;
s5: standing the discharged semi-finished product for 24 hours, and sampling and detecting the semi-finished product again to obtain a qualified semi-finished product for later use;
s6: taking the packaging material, sending the unpacked packaging material to a packaging material disinfection room for disinfection for more than 45min, carrying out first inspection on the qualified semi-finished product and the matched packaging material, and then conveying to a filling machine for filling;
s7: after filling, packaging and coding the product;
s8: and inspecting the packaged product, filling a finished product warehousing bill after the product is qualified, and delivering the finished product to warehouse.
6. The method of claim 5, wherein: in step S1, it is checked whether each raw material has a pass label, and if there is a mistake or no pass label, the feeding is prohibited.
7. The method of claim 5, wherein: in the step S2, the weight of the weighing bottle is removed first when the raw material is weighed, and an electronic scale with the precision of +/-0.2 g is adopted when the raw material is weighed to be less than 10g, an electronic scale with the weight of 3kg is adopted when the raw material is weighed to be 10g-3000g, and an electronic scale with the weight of 150kg is adopted when the raw material is weighed to be more than 3 kg.
8. The method of claim 5, wherein: in step S4, when the semi-finished sample is transparent liquid-free in appearance and has a pH of 4.0-10.0 (direct measurement), it is judged to be acceptable.
9. The method of claim 5, wherein: in step S5, when the semi-finished sample is transparent liquid-free in appearance and has a pH of 4.0-10.0 (direct measurement), it is judged to be acceptable.
10. The method of claim 5, wherein: in step S8, the test items include package labels, appearance indicators, sensory indicators, physical and chemical indicators, and hygiene indicators.
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