CN113040130A - Multifunctional mechanical perfusion liver trough device for rats - Google Patents
Multifunctional mechanical perfusion liver trough device for rats Download PDFInfo
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- CN113040130A CN113040130A CN202110260953.1A CN202110260953A CN113040130A CN 113040130 A CN113040130 A CN 113040130A CN 202110260953 A CN202110260953 A CN 202110260953A CN 113040130 A CN113040130 A CN 113040130A
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- liver
- trough
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- perfusion
- temperature control
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
Abstract
The invention relates to the technical field of medical treatment and experimental equipment, in particular to a multifunctional rat mechanical perfusion liver trough device, which comprises: the liver trough is placed on the liver trough table and used for containing perfusate and substances to be preserved; the temperature control assembly is arranged on the outer circumference and the bottom of the liver groove, detects the temperature of the perfusate in the liver groove and heats the liver groove according to the detection result so as to maintain the perfusate in a set temperature range; the plurality of restraint assemblies are arranged on the liver trough table at the side of the liver trough at intervals and used for fixing the mechanical perfusion pipeline; the invention has the beneficial effects that: the fixed mechanical perfusion pipeline of restraint subassembly and the blood vessel that sets up has reduced the position that leads to the liver because the device position changes in the perfusion process and has changed, and the temperature control assembly who sets up maintains the temperature of perfusate in the liver groove and in the settlement scope, has guaranteed that the temperature around the liver maintains invariably among the perfusion process, has satisfied different perfusion conditions.
Description
Technical Field
The invention relates to the technical field of medical treatment and experimental equipment, in particular to a multifunctional rat mechanical perfusion liver trough device.
Background
The lack of currently available supplies for liver has greatly limited the development of liver transplants. In recent years, extracorporeal machine perfusion has been developed year by year, and becomes a reliable preservation mode capable of improving the quality and preservation time of the liver. At present, the machine mainly comprises three perfusion modes according to different perfusion temperatures, namely low-temperature (4 ℃), sub-low-temperature (20 ℃) and normal-temperature (37 ℃) mechanical perfusion. The perfusion effect is different under different temperatures, the low-temperature mechanical perfusion depends on low temperature, the metabolism of liver cells is inhibited, so that the cell damage caused by oxygen deficiency and insufficient energy metabolism is avoided, meanwhile, the metabolic waste under the low-temperature condition is taken out of the liver through continuous circulation, and a satisfactory perfusion effect is obtained, but the biliary tract injury is easily caused by long-time preservation, and the method is an ideal method for preserving the liver for a short time. The sub-low temperature mechanical perfusion temperature is higher than 4 ℃, the metabolic capability of the liver is improved to a certain extent, and the preservation time of the liver is longer compared with the low temperature perfusion in the aspect of preserving the liver because the oxygen is provided to maintain the metabolism of the liver to a relatively ideal state. The normal-temperature oxygen-carrying mechanical perfusion is the perfusion closest to the physiological environment in three perfusion modes, can maintain the metabolic activity of a transplant to the maximum extent, and meanwhile, because the liver metabolism is maintained at a normal level, the function of the liver can be effectively evaluated by measuring related indexes in the perfusate, and meanwhile, the quality of the liver can be effectively regulated by medicine intervention in the perfusion process.
At present, the mechanical perfusion part is applied to clinic, but the study on the mechanical perfusion is mainly an animal experiment, and the study on the mechanical perfusion of rat liver is the most extensive in the animal experiment, and no uniformly accepted rat mechanical perfusion machine exists at present. The mechanical rat perfusion machines used in the centers are different, but the perfusion of the centers is mainly focused on the control of the temperature of the perfusate in terms of temperature control.
The mechanical perfusion at the present stage is mainly controlled by a water bath and an external heater for heating or under a specific environment, so that the temperature of perfusate in a perfusion system can meet the perfusion requirement, the perfusion mode ignores the environment around the liver, most liver grooves for perfusing and placing the liver are culture dishes of cells, the dishes do not have the temperature regulation function, and the liver grooves are directly placed in the environment of room temperature, so that the mechanical perfusion at the low temperature and the normal temperature can influence the functions of the liver.
Disclosure of Invention
The invention aims to provide a multifunctional rat mechanical perfusion liver trough device to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
a multi-functional rat mechanical perfusion liver trough device, comprising: the liver trough is placed on the liver trough table and used for containing perfusate and substances to be preserved; the temperature control assembly is arranged on the outer circumference and the bottom of the liver groove, detects the temperature of the perfusate in the liver groove and heats the liver groove according to the detection result so as to maintain the perfusate in a set temperature range; and the plurality of restraint assemblies are arranged on the liver trough table at the side of the liver trough at intervals and used for fixing the mechanical perfusion pipeline.
As a further scheme of the invention: the temperature control assembly comprises a temperature control unit and a heat source, and the heat source is communicated with a heat insulation layer arranged on the liver trough through a heat exchange loop; the temperature control unit controls the heat source to circularly convey the medium to the heat-insulating layer to exchange heat with the perfusate in the liver tank, and is used for maintaining the perfusate in the liver tank within a set temperature range.
As a still further scheme of the invention: the temperature control assembly further comprises an electric heating unit, the electric heating unit is electrically connected with the temperature control unit, and the temperature control unit controls the electric heating unit to heat the heat preservation layer and media in the heat preservation layer.
As a still further scheme of the invention: the liver groove comprises an interlayer structure to form a heat insulation layer, and a connector which is communicated with the heat insulation layer and used for connecting the heat exchange loop is arranged on the interlayer structure.
As a still further scheme of the invention: the outer circumferential surface of the sandwich structure is relatively provided with two fixing parts, and the liver slot table supports the liver slot in a limiting way through the fixing parts.
As a still further scheme of the invention: the temperature control unit comprises a temperature controller and a temperature detection element electrically connected with the temperature controller, the temperature detection element is used for detecting the temperature of the perfusate in the liver tank and feeding back the temperature to the temperature controller, and the temperature controller controls the heat source to work; the temperature detection element comprises at least one temperature control probe which is arranged on the outer circumferential surface of the liver trough.
As a still further scheme of the invention: the restraint assembly comprises an upright post movably arranged on the liver trough table and a clamping component arranged on the upright post, and the clamping component clamps and fixes the mechanical perfusion pipeline; the clamping component is a blood vessel fixing clamp.
As a still further scheme of the invention: the liver groove table is provided with an installation groove, and the bottom of the upright post is embedded in the installation groove and is fixed through a locking piece.
Compared with the prior art, the invention has the beneficial effects that: when rat liver preserved, the restraint subassembly of setting for fixed mechanical perfusion pipeline and blood vessel, through fixed good mechanical perfusion pipeline and blood vessel position, reduced the perfusion in-process because the device position changes the position that leads to the liver and change, the temperature control assembly of setting maintains the temperature of perfusate in the liver groove and at the settlement scope, through the control of temperature control assembly to the temperature, guaranteed that the temperature around the liver maintains invariably among the perfusion process, satisfied different perfusion conditions.
Drawings
Fig. 1 is a front view of a multifunctional rat mechanical perfusion liver trough device in an embodiment of the invention.
Fig. 2 is a top view of the multifunctional rat mechanical perfusion liver trough device in the embodiment of the invention.
FIG. 3 is a schematic structural diagram of a liver trough according to an embodiment of the present invention.
Fig. 4 is a schematic sectional view taken along the direction a-a in fig. 3.
In the drawings: 1. externally fixing the upright post; 2. a vascular cannula clamp; 3. a temperature probe; 4. a temperature controller; 5. a water bath water outlet; 6. a water bath water injection port; 7. heating the electrode; 8. a liver trough; 9. a liver slot table; 10. and fixing the handle.
Detailed Description
Reference will now be made in detail to the exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, like numbers in different drawings represent the same or similar elements unless otherwise indicated. The implementations described in the exemplary embodiments below are not intended to represent all implementations consistent with the present disclosure. Rather, they are merely examples of apparatus and methods consistent with certain aspects of the present disclosure, as detailed in the appended claims.
Referring to fig. 1, in one embodiment of the present invention, a multifunctional rat mechanical perfusion liver trough device comprises: the liver trough 8 is placed on the liver trough table 9 and used for containing perfusate and substances to be preserved; the temperature control assembly is arranged on the outer circumference and the bottom of the liver groove, detects the temperature of the perfusate in the liver groove and heats the liver groove according to the detection result so as to maintain the perfusate in a set temperature range; and a plurality of constraint components are arranged on the liver slot table 9 at the side of the liver slot at intervals and used for fixing the mechanical perfusion pipeline.
Specifically, in the case of rat liver preservation, the material to be preserved is rat liver. Placing the rat liver to be preserved in the liver groove 8, and carrying out mechanical perfusion related setting; mechanically perfusing the associated mechanical perfusion line and blood vessel is fixed by the restraint assembly. Then, starting a temperature control assembly, and carrying out temperature detection on the perfusate in the liver slot by the temperature control assembly; and according to the detection result, heating or heat preservation treatment is carried out on the liver groove; so that the perfusate in the liver slot and the temperature around the liver are maintained to the set range.
Consequently, the restraint subassembly of setting for fixed mechanical perfusion pipeline and blood vessel, through fixed good mechanical perfusion pipeline and blood vessel position, reduced among the perfusion process because the device position changes and lead to the position of liver to change, the temperature control assembly of setting maintains the temperature of perfusate in the liver groove and at the settlement scope, through the control of temperature control assembly to the temperature, has guaranteed that the temperature around the perfusion in-process liver maintains invariably, has satisfied different perfusion conditions.
In some embodiments, the temperature control assembly comprises a temperature control unit and a heat source, and the heat source is communicated with a heat insulation layer arranged on the liver trough through a heat exchange loop; the temperature control unit controls the heat source to circularly convey the medium to the heat-insulating layer to exchange heat with the perfusate in the liver tank, and is used for maintaining the perfusate in the liver tank within a set temperature range.
The heat source can adopt a water bath, and the water bath circularly conveys water as a medium to the heat-insulating layer; for example, when mechanical perfusion is performed at normal temperature (37 ℃), the temperature control unit controls the heat source to circularly convey water to the heat insulation layer to exchange heat with the perfusion liquid in the liver trough, so that the perfusion liquid in the liver trough is maintained at 37 ℃, the temperature around the liver trough is well controlled, and the physiological function of the liver is kept good.
As shown in fig. 3 and 4, the liver trough comprises a sandwich structure to form a heat insulation layer, and a connector which is communicated with the heat insulation layer and is used for connecting the heat exchange loop is arranged on the sandwich structure; the connecting ports are respectively a water bath water outlet 5 and a water bath water filling port 6; the heat source is a water bath kettle, the water bath kettle is communicated with the water bath water outlet 5 and the water bath water filling port 6 through a heat exchange loop, and the heat exchange loop is composed of a plurality of connecting pipes.
The connecting pipe is provided with an adjusting valve, and the flow of the medium in the heat exchange loop is adjusted through the adjusting valve, so that the heat exchange efficiency of the heat insulation layer is adjusted.
The liver groove is formed into an interlayer structure with a heat insulation layer through steel extrusion forming, and the surface of the liver groove is coated with a film, so that the anti-rust and anti-corrosion effects are achieved, and the service life of the liver groove is prolonged.
In addition, as shown in fig. 3 and 4, two fixing parts are oppositely arranged on the outer circumferential surface of the sandwich structure, and the liver trough table is used for supporting the liver trough in a limiting way through the fixing parts. The fixed part is provided with a fixed handle which is integrally processed and formed with the liver groove; the fixed handle 10 can not only play a role of limiting and supporting the liver groove; the liver groove can be conveniently taken by the fixed handle 10.
Referring to fig. 1 and 4, in another embodiment of the present invention, the temperature control assembly further includes an electric heating unit, the electric heating unit is electrically connected to the temperature control unit, and the temperature control unit controls the electric heating unit to heat the insulating layer and the medium therein.
The electric heating unit adopts a heating electrode 7, and the heating electrode 7 is arranged at the bottom of the liver trough; and the heating electrode 7 is matched with the water bath to supplement heat to the heat-insulating layer.
In some embodiments, the heating electrode 7 replaces the heat source to solely supplement heat for the heat preservation layer, and the heat source is not required to be configured; the construction cost of the device is saved, the overall layout of the device is facilitated, and meanwhile, more operation space is provided for the operation of mechanical filling.
As shown in fig. 1, in another embodiment, the temperature control unit includes a temperature controller 4 and a temperature detecting element electrically connected to the temperature controller 4, the temperature detecting element is used for detecting the temperature of the perfusate in the liver tank and feeding the temperature back to the temperature controller, and the temperature controller controls the heat source to work.
The temperature controller 4 is connected with a power supply, and the power supply provides electric energy for the temperature detection element and the heating electrode 7 through the temperature controller; the temperature detecting element comprises at least one temperature control probe 3, the temperature control probe 3 is arranged on the outer circumferential surface of the liver groove 8, specifically, the number of the temperature control probes can be 1, the temperature control probes detect the temperature of the perfusate in the liver groove, and the temperature controller timely adjusts the temperature of the perfusate in the liver groove according to a detection result, namely, the temperature of the perfusate in the liver groove is adjusted by changing the speed of conveying the medium by the water bath kettle, the temperature of the conveying medium by the water bath kettle is changed, so that the temperature of the perfusate in the liver groove is maintained within a proper range when the medium is conveyed to the heat preservation layer.
In practical application, the number of the temperature control probes 3 can be 2 or more, and the temperature of the perfusate in the liver groove can be accurately and reliably detected by arranging the temperature control probes 3 at a plurality of positions of the liver groove, so that the distribution difference of the temperature of each part in the liver groove can be mastered; then the temperature controller 4 controls the heating electrode to heat so as to maintain the proper temperature.
It should be noted that the temperature controller, the temperature control probe and the heating electrode adopted in the present invention are all applications in the prior art, and those skilled in the art can implement the functions to be achieved according to the related description, or implement the technical characteristics to be achieved through similar techniques, and will not be described in detail herein.
Referring to fig. 1 and 2, in another embodiment of the present invention, the constraint assembly includes a pillar movably mounted on the liver table, and a clamping member mounted on the pillar, wherein the clamping member clamps and fixes the mechanical perfusion circuit; the clamping component adopts a blood vessel fixing clamp 2.
Specifically, the three upright columns are arranged on the liver trough table at intervals as outer fixed upright columns 1, and the blood vessel fixing clamp 2 is arranged on the outer fixed upright columns 1. The relative position of the outer fixed upright post 1 on the liver trough table and the position of the blood vessel fixing clamp 2 on the outer fixed upright post are adjusted; the mechanical perfusion pipeline, namely the blood vessel of the liver can be fixed at a proper position through the blood vessel fixing clamp 2, so that the safety and the reliability of the mechanical perfusion are kept.
In order to improve the flexibility after the installation of the restraint assembly and provide more operation spaces for liver perfusion, as shown in fig. 2, an installation groove is formed in the liver trough table, the bottom of the stand column is embedded in the installation groove and is fixed through a locking piece, and the fastening piece adopts a bolt or a bolt.
The working principle of the invention is as follows: placing the rat liver to be preserved in the liver groove 8, and carrying out mechanical perfusion related setting; mechanically perfusing the associated mechanical perfusion line and blood vessel is fixed by the restraint assembly. Then, starting a temperature control assembly, and carrying out temperature detection on the perfusate in the liver slot by the temperature control assembly; and according to the detection result, heating or heat preservation treatment is carried out on the liver groove; so that the perfusate in the liver slot and the temperature around the liver are maintained to the set range.
Other embodiments of the disclosure will be apparent to those skilled in the art from consideration of the specification and practice of the disclosure herein. This application is intended to cover any variations, uses, or adaptations of the disclosure following, in general, the principles of the disclosure and including such departures from the present disclosure as come within known or customary practice within the art to which the disclosure pertains. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the disclosure being indicated by the following claims.
It will be understood that the present disclosure is not limited to the precise arrangements described above and shown in the drawings and that various modifications and changes may be made without departing from the scope thereof. The scope of the present disclosure is limited only by the appended claims.
Claims (10)
1. A multifunctional rat mechanical perfusion liver trough device is characterized by comprising:
the liver trough is placed on the liver trough table and used for containing perfusate and substances to be preserved;
the temperature control assembly is arranged on the outer circumference and the bottom of the liver groove, detects the temperature of the perfusate in the liver groove and heats the liver groove according to the detection result so as to maintain the perfusate in a set temperature range;
and the plurality of restraint assemblies are arranged on the liver trough table at the side of the liver trough at intervals and used for fixing the mechanical perfusion pipeline.
2. The multifunctional mechanical rat perfusion liver trough device according to claim 1, wherein the temperature control assembly comprises a temperature control unit and a heat source, and the heat source is communicated with a heat insulation layer arranged on the liver trough through a heat exchange loop; the temperature control unit controls the heat source to circularly convey the medium to the heat-insulating layer to exchange heat with the perfusate in the liver tank, and is used for maintaining the perfusate in the liver tank within a set temperature range.
3. The multifunctional rat mechanical perfusion liver trough device according to claim 2, wherein the temperature control assembly further comprises an electric heating unit, the electric heating unit is electrically connected with the temperature control unit, and the temperature control unit controls the electric heating unit to heat the heat preservation layer and the medium therein.
4. The multifunctional mechanical perfusion liver trough device for rats according to claim 2, wherein the liver trough comprises a sandwich structure to form a heat insulation layer, and a connector for connecting the heat exchange loop is formed on the sandwich structure and penetrates through the heat insulation layer.
5. The multifunctional rat mechanical perfusion liver trough device according to claim 4, wherein the outer circumferential surface of the sandwich structure is oppositely provided with two fixing parts, and the liver trough table is used for supporting the liver trough in a limiting way through the fixing parts.
6. The multifunctional rat mechanical perfusion liver trough device according to claim 2, wherein the temperature control unit comprises a temperature controller and a temperature detection element electrically connected with the temperature controller, the temperature detection element is used for detecting the temperature of the perfusion fluid in the liver trough and feeding back the temperature to the temperature controller, and the temperature controller controls the heat source to work.
7. The multifunctional rat mechanical perfusion liver trough device according to claim 6, wherein the temperature detection element comprises at least one temperature control probe disposed on an outer circumferential surface of the liver trough.
8. The multi-functional rat mechanical perfusion liver trough device of claim 1, wherein the restraining assembly comprises a post movably mounted on the liver trough table, a clamping member mounted on the post, the clamping member clamping the stationary mechanical perfusion line.
9. The multifunctional mechanical perfusion liver trough device for rats of claim 8, wherein the liver trough table is provided with an installation groove, and the bottom of the upright post is embedded in the installation groove and fixed by a locking member.
10. The multifunctional rat mechanical perfusion liver trough device according to claim 8 or 9, wherein the clamping component is a blood vessel fixing clamp.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110260953.1A CN113040130A (en) | 2021-03-10 | 2021-03-10 | Multifunctional mechanical perfusion liver trough device for rats |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110260953.1A CN113040130A (en) | 2021-03-10 | 2021-03-10 | Multifunctional mechanical perfusion liver trough device for rats |
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| CN113040130A true CN113040130A (en) | 2021-06-29 |
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| CN102065685A (en) * | 2008-05-14 | 2011-05-18 | 私人诊所生物医学研究基金会 | Device for the preservation of a hepatic graft in normothermia |
| CN202232703U (en) * | 2011-08-19 | 2012-05-30 | 天津市第一中心医院 | Constant-temperature perfusion system for in-vitro liver |
| CN205987870U (en) * | 2016-08-31 | 2017-03-01 | 郑州人民医院 | A kind of disposable Liver and kidney transplants intrusion pipe |
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| CN209473458U (en) * | 2018-08-17 | 2019-10-11 | 湖州露湖鄱生物科技有限公司 | A kind of liver room temperature machine perfusion system |
| CN111869657A (en) * | 2020-08-17 | 2020-11-03 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | In-vitro liver perfusion system, connector tube assembly and connecting method thereof |
| US20210022334A1 (en) * | 2019-07-24 | 2021-01-28 | SCREEN Holdings Co., Ltd. | Organ container |
-
2021
- 2021-03-10 CN CN202110260953.1A patent/CN113040130A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102065685A (en) * | 2008-05-14 | 2011-05-18 | 私人诊所生物医学研究基金会 | Device for the preservation of a hepatic graft in normothermia |
| CN202232703U (en) * | 2011-08-19 | 2012-05-30 | 天津市第一中心医院 | Constant-temperature perfusion system for in-vitro liver |
| CN205987870U (en) * | 2016-08-31 | 2017-03-01 | 郑州人民医院 | A kind of disposable Liver and kidney transplants intrusion pipe |
| CN209473458U (en) * | 2018-08-17 | 2019-10-11 | 湖州露湖鄱生物科技有限公司 | A kind of liver room temperature machine perfusion system |
| CN110026702A (en) * | 2019-05-09 | 2019-07-19 | 泰铂（上海）环保科技股份有限公司 | It is a kind of for welding the welding tooling and its application method of condenser pipe |
| US20210022334A1 (en) * | 2019-07-24 | 2021-01-28 | SCREEN Holdings Co., Ltd. | Organ container |
| CN111869657A (en) * | 2020-08-17 | 2020-11-03 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | In-vitro liver perfusion system, connector tube assembly and connecting method thereof |
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Application publication date: 20210629 |