CN113015749A - 靶向cd3的抗体、双特异性抗体及其用途 - Google Patents
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
本发明公开了一种靶向CD3的抗体、双特异性抗体及其用途。所述的靶向CD3的抗体包含轻链可变区(VL)和重链可变区(VH)，所述VL为如SEQ ID NO:56所示的氨基酸序列或其突变；所述VH在如SEQ ID NO:42所示的氨基酸序列上发生突变，所述突变选自一个或多个以下位点：第30位、第73位、第76位、第78位、第93位和第94位的氨基酸残基。所述双特异性抗体包括第一蛋白功能区和第二蛋白功能区，其中，所述第一蛋白功能区包含如上所述的靶向CD3的抗体。本发明的靶向CD3的抗体降低细胞因子释放综合征带来的毒性，由其制备的双特异性抗体稳定且具有T细胞结合能力，降低了生产难度。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
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| Application Number | Priority Date | Filing Date | Title |
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| CN2019109413286 | 2019-09-30 | ||
| CN201910941328 | 2019-09-30 | ||
| PCT/CN2020/118606 WO2021063330A1 (zh) | 2019-09-30 | 2020-09-29 | 靶向cd3的抗体、双特异性抗体及其用途 |
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| US (1) | US20220348661A1 (zh) |
| EP (1) | EP4039707A4 (zh) |
| JP (2) | JP2022550832A (zh) |
| KR (1) | KR20220071263A (zh) |
| CN (1) | CN113015749B (zh) |
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| WO2023011338A1 (zh) * | 2021-08-02 | 2023-02-09 | 信达生物制药(苏州)有限公司 | 抗CD79b×CD3双特异性抗体及其用途 |
| CN116514979A (zh) * | 2022-05-09 | 2023-08-01 | 华兰基因工程有限公司 | 特异性结合pv-1蛋白的抗体或其抗原结合片段hlpv-p09及其应用 |
| WO2024041435A1 (zh) * | 2022-08-22 | 2024-02-29 | 英脉德医疗科技(广东)有限公司 | 肿瘤微环境特异激活的Her2-CD3双特异性抗体 |
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| KR20230079409A (ko) * | 2020-09-29 | 2023-06-07 | 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드 | 항-cd3 항체 및 이의 용도 |
| EP4349870A1 (en) * | 2021-06-02 | 2024-04-10 | Qure Biotechnology (Shanghai) Co., Ltd. | Anti-cd3 antibody variant, fusion protein, and application |
| TWI833244B (zh) * | 2021-06-18 | 2024-02-21 | 大陸商和鉑醫藥（上海）有限責任公司 | 一種雙抗組合及其應用 |
| KR20240046557A (ko) | 2021-08-18 | 2024-04-09 | 하버 바이오메드 (상하이) 컴퍼니 리미티드 | 항-b7-h4 항체 및 이의 제조 방법과 용도 |
| CA3234822A1 (en) | 2021-10-28 | 2023-05-04 | Suman Kumar VODNALA | Methods for culturing cells expressing ror1-binding protein |
| WO2023192606A2 (en) * | 2022-04-01 | 2023-10-05 | Cytomx Therapeutics, Inc. | Cd3-binding proteins and methods of use thereof |
| WO2024064958A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
| WO2024064952A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells overexpressing c-jun |
| WO2024077174A1 (en) | 2022-10-05 | 2024-04-11 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
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- 2020-09-29 JP JP2022520343A patent/JP2022550832A/ja active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| EP4039707A1 (en) | 2022-08-10 |
| TW202126694A (zh) | 2021-07-16 |
| AU2020359928A1 (en) | 2022-04-21 |
| EP4039707A4 (en) | 2022-11-16 |
| CN113015749B (zh) | 2022-01-21 |
| JP2024036342A (ja) | 2024-03-15 |
| US20220348661A1 (en) | 2022-11-03 |
| CA3152438A1 (en) | 2021-04-08 |
| JP2022550832A (ja) | 2022-12-05 |
| KR20220071263A (ko) | 2022-05-31 |
| WO2021063330A1 (zh) | 2021-04-08 |
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