CN113004428B - Preparation method of carboxyl ferric maltose - Google Patents
Preparation method of carboxyl ferric maltose Download PDFInfo
- Publication number
- CN113004428B CN113004428B CN201911327843.1A CN201911327843A CN113004428B CN 113004428 B CN113004428 B CN 113004428B CN 201911327843 A CN201911327843 A CN 201911327843A CN 113004428 B CN113004428 B CN 113004428B
- Authority
- CN
- China
- Prior art keywords
- solution
- carboxyl
- sodium carbonate
- ferric
- maltose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2265—Oxides; Hydroxides of metals of iron
Abstract
The invention discloses a preparation method of carboxyl ferric maltose, which comprises the steps of adding a sodium carbonate solution into a mixed system of a carboxyl maltodextrin solution and a ferric trichloride solution at a constant speed within 0.3-4 hours, and controlling the adding speed of the sodium carbonate solution to obtain the carboxyl ferric maltose with target molecular weight and molecular weight distribution coefficient; wherein, the mass ratio of ferric trichloride to sodium carbonate is 2-3. The method combines actual production, fixes the raw material proportion, material concentration, pH value, temperature and the like of a reaction system, and controls the uniform adding speed of the sodium carbonate solution to obtain the carboxyl maltose iron with different target molecular weights.
Description
Technical Field
The invention belongs to the field of pharmaceutical chemicals, relates to a preparation method of carboxyl ferric maltose, and particularly relates to a method for controlling the molecular weight of carboxyl ferric maltose in a carboxyl ferric maltose synthesis reaction, which is suitable for controlling the molecular weight of a final product carboxyl ferric maltose in a carboxyl ferric maltose synthesis process.
Background
Iron deficiency anemia is a common nutritional disorder, anemia arising from the inability of iron storage in vivo to meet the needs of normal erythropoiesis. Ferric carboxymaltose is a novel medicament for treating or preventing iron-deficiency anemia.
The synthetic route of the carboxyferric maltose is as follows:
controlling the pH value of the maltodextrin solution to be 9.0-11.0 by adopting a sodium hydroxide solution, and moderately oxidizing the maltodextrin solution into a carboxyl maltodextrin solution by using sodium bromide as a catalyst through a 10% sodium hypochlorite solution; complexing the carboxyl maltodextrin solution and the ferric trichloride solution under the condition of sodium carbonate, and carrying out alkali, acid and heat curing to prepare a carboxyl maltodextrin solution; adding ethanol into the carboxyl ferric maltose solution for crystallization, refining and drying to obtain the carboxyl ferric maltose.
The iron carboxymaltose molecular weight is mainly expressed in terms of weight average molecular weight (Mw). The ferric carboxymaltose with different molecular weight distributions has certain characteristics in the aspects of solubility, bioavailability, stability and the like. Therefore, the carboxyl maltose iron with different weight-average molecular weights (110000-230000) can be produced in a certain range according to actual requirements in actual production.
Currently, iron supplementation is generally characterized by the iron carboxymaltose molecular weight attribute: weight average molecular weight (Mw): 110000 to 230000, number average molecular weight (Mn): not less than 60000 and a molecular weight distribution coefficient (Mw/Mn) not more than 1.9.
Related patents CN106977621A, CN108129582A, CN1705682A (original patents) and the like all relate to the synthesis of ferric carboxymaltose, but there is no corresponding description on the molecular weight control of ferric carboxymaltose. In CN1705682A and related documents, the dextrose equivalent of maltodextrin was controlled to obtain the desired target carboxymaltoferric molecular weight and distribution.
Disclosure of Invention
The invention provides a simple and effective method for obtaining the carboxyl maltose iron with different molecular weights in the synthesis reaction of the carboxyl maltose iron.
The carboxyl maltodextrin iron is prepared with maltodextrin as initial material, and through oxidation with hypochlorous acid in alkaline condition to obtain carboxyl maltodextrin, and reaction with ferric trichloride to form macromolecular compound with iron ion as core and carboxyl maltodextrin as shell and stable spatial structure. The final molecular weight distribution of the ferric carboxymaltose has close relation with the relevant parameter conditions of the reaction system.
The inventor creatively discovers that: in a complex reaction system of ferric chloride solution and carboxyl maltodextrin solution, the proportion of sodium carbonate to ferric chloride, the concentration of the sodium carbonate solution and the concentration of the ferric chloride solution are fixed, the molecular weight of the carboxyl maltodextrin is only related to the time (or adding speed) for adding the sodium carbonate solution at a constant speed in the whole process, but is not related to the quantity of materials in the reaction system, and the carboxyl maltodextrin iron with specific molecular weight and molecular weight distribution coefficient (1.35-1.55) can be obtained by controlling the adding speed of the sodium carbonate solution. The molecular weight of the final product of the ferric carboxymaltose is related to the adding time of the sodium carbonate solution, and is independent of the amount of reactants, namely the molecular weight of the final ferric carboxymaltose is not obviously different between small batches of reactants and large batches of reactants under the condition required by the invention.
The purpose of the invention is realized by the following technical scheme:
a method for preparing carboxyl ferric maltose comprises the steps of adding a sodium carbonate solution into a mixed system of a carboxyl maltodextrin solution and a ferric trichloride solution at a constant speed, and controlling the adding speed of the sodium carbonate solution to obtain the carboxyl ferric maltose with target molecular weight and molecular weight distribution coefficient.
The weight ratio of carboxymaltodextrin (calculated as raw maltodextrin) to ferric chloride (calculated as ferric chloride hexahydrate) was 100.
According to the requirements of the invention, the proportion of ferric trichloride and sodium carbonate is fixed, and the mass ratio of ferric trichloride to sodium carbonate is 2-3.
The concentration of ferric trichloride in the ferric trichloride solution is 70-80% (w/w).
The concentration of sodium carbonate in the sodium carbonate solution is 20-35% (w/w).
As the preferred technical scheme of the invention, the carboxyl maltodextrin solution and the ferric chloride solution are firstly mixed uniformly, the temperature is kept between 50 and 70 ℃, and the sodium carbonate solution is added into the mixed system at a constant speed under stirring.
Further preferably, sodium carbonate solution is added into the mixed system at constant speed within 0.3-4 hours.
Further preferably, the uniform adding of the sodium carbonate solution into the mixed system is realized within 0.3-4 hours by using equipment capable of controlling flow rate, such as a peristaltic pump, an overhead tank and the like.
During the complexing reaction, the main function of the sodium carbonate solution is to stabilize the pH value of the system within a certain range, but the pH value of the system does not need to be monitored during the whole complexing reaction. The core of the invention is that sodium carbonate solution is added at constant speed, but the time of the whole adding process is controlled, for example, the adding time is 0.5 hour, 1.0 hour, 1.5 hours and the like, so that the final product of carboxyl maltose iron corresponds to different target molecular weights. The molecular weight of the carboxyl ferric maltose and the uniform speed dripping time of the sodium carbonate solution are in a linear relation: y =25185x +77862 2 =0.9919, wherein y represents a weight average molecular weight of carboxymaltose iron, and x represents a dropping time of the sodium carbonate solution. The weight average molecular weight (Mw) of the carboxyl maltose iron is 100000-230000, and the molecular weight distribution coefficient (Mw/Mn) is 1.35-1.55.
The preferable technical scheme of the preparation method of the carboxyl maltose iron further comprises the following steps: after the reaction is finished, alkali curing, acid curing and high-temperature curing are sequentially carried out to obtain a stable ferric carboxymaltose solution, and absolute ethyl alcohol is added to separate out the ferric carboxymaltose.
The alkali curing is as follows: the pH value of the solution is adjusted to 10.0-12.0 by 30% sodium hydroxide solution, the temperature is controlled to 50-70 ℃, and the solution is stirred for 0.5 hour.
The acid is cured as follows: adding 20% hydrochloric acid solution to regulate pH value to 5.0-6.0, controlling temperature to 50-70 deg.c and stirring for 0.5 hr.
The high-temperature curing comprises the following steps: stirring for 0.5 hour at 90-100 ℃.
The carboxyl maltodextrin solution is prepared by oxidizing maltodextrin serving as an initial raw material with sodium bromide serving as a catalyst under the alkaline condition of pH 9.0-11.0 by hypochlorous acid.
Specifically, the carboxyl maltodextrin solution is prepared by the following method: dissolving the maltodextrin in 1-2 times of water, using sodium bromide accounting for 1-2% of the weight of the maltodextrin as a catalyst, adjusting the pH value to 9.0-11.0 by using 30% sodium hydroxide solution, controlling the temperature to be 25-40 ℃, and adding 10% sodium hypochlorite solution accounting for 0.8-1 times of the weight of the maltodextrin under the condition of stirring to obtain carboxyl maltodextrin solution.
And (3) carrying out complexation reaction on the carboxyl maltose and the raw material containing ferric ions to generate the carboxyl ferric maltose. In the complexing process, the molecular weight of the carboxyl ferric maltose is greatly related to the DE value of maltodextrin, the raw material ratio, the material concentration, the pH value, the temperature, the complexing time and the like of a reaction system. The DE value of the maltodextrin is 10-15.
The invention has the beneficial effects that:
the method combines the actual production, fixes the raw material proportion, the material concentration, the pH value, the temperature and the like of the reaction system, and controls the sodium carbonate solution to be added into the reaction system at a constant speed (namely the length of the constant-speed dropping time) to obtain the carboxyl ferric maltose with different target molecular weights.
The method is simple, has low requirements on equipment and technology, is particularly suitable for industrial operation, and has great practical significance in actual production.
Drawings
FIG. 1 is a graph showing the trend of the uniform dropping time of a sodium carbonate solution and the molecular weight of carboxyl maltose iron; wherein the abscissa is the dropping time (h), and the ordinate is the weight-average molecular weight or the number-average molecular weight.
FIG. 2 is a graph showing the molecular weight trends of ferric carboxymaltose at different batches under the same dropping time of a sodium carbonate solution; wherein the abscissa is the amount (g) of sodium carbonate, and the ordinate is the weight average molecular weight or the number average molecular weight.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments.
Example 1
Adding 100g of maltodextrin into 200ml of water, stirring and dissolving, adding 1g of sodium bromide, adding 30% sodium hydroxide solution to adjust the pH value of the maltodextrin solution to 9.0-11.0, controlling the temperature to be 25-40 ℃, and adding 80g of 10% sodium hypochlorite solution under the stirring condition to obtain the carboxyl maltodextrin solution.
The carboxyl maltodextrin solution and ferric chloride solution (ferric chloride concentration 75% w/w, prepared by adding water 220g ferric chloride hexahydrate) are mixed first, stirred, the temperature is controlled at 50-70 ℃, sodium carbonate solution (concentration 25% w/w, prepared by adding water 110g sodium carbonate) is added dropwise at uniform speed by a peristaltic pump, the flow rate is set, and the addition of the sodium carbonate solution is controlled to be finished within 0.3 hour. After the reaction is finished, adding 30 percent sodium hydroxide solution, adjusting the pH value of the solution to 10.0-12.0, controlling the temperature to 50-70 ℃, and stirring for 0.5 hour (alkali curing); adding 20% hydrochloric acid solution, adjusting the pH value of the solution to 5.0-6.0, controlling the temperature to 50-70 ℃, and stirring for 0.5 hour (acid curing); heating to 90-100 ℃, and continuing stirring for 0.5 hour (high-temperature solidification) to obtain a stable carboxyl maltose iron solution; after cooling to normal temperature, 160ml of absolute ethanol was added to precipitate iron carboxymaltose.
Example 2
The carboxymaltodextrin solution was prepared as in example 1.
The carboxyl maltodextrin solution and ferric chloride solution (ferric chloride concentration 75% w/w, prepared by adding 220g of water into ferric chloride hexahydrate) are mixed, stirred, the temperature is controlled to be 50-70 ℃, sodium carbonate solution (the concentration is 25% w/w, prepared by adding 110g of water into sodium carbonate) is added at uniform speed by a peristaltic pump, the flow rate is set, the sodium carbonate solution is controlled to be added within 0.5 hour, after the reaction is finished, the stable carboxyl ferric maltose solution is obtained by acid, alkali and high-temperature solidification, and 160ml of absolute ethyl alcohol is added to separate out the carboxyl ferric maltose.
Example 3
The carboxymaltodextrin solution was prepared as in example 1.
The carboxyl maltodextrin solution and ferric chloride solution (ferric chloride concentration 75% w/w, prepared by adding water 220g ferric chloride hexahydrate) are mixed first, stirred, controlled at 50-70 deg.C, sodium carbonate solution (concentration 25% w/w, prepared by adding water 110g sodium carbonate) is added dropwise at uniform speed by a peristaltic pump, the flow rate is set, and the addition of sodium carbonate solution is controlled to be finished within 1.0 hour. After the reaction is finished, acid, alkali and high-temperature solidification are carried out to obtain stable carboxyl maltose iron solution, and then 160ml of absolute ethyl alcohol is added to separate out the carboxyl maltose iron.
Example 4
The carboxymaltodextrin solution was prepared as in example 1.
The carboxyl maltodextrin solution and ferric chloride solution (ferric chloride concentration 75% w/w, prepared by adding water 220g ferric chloride hexahydrate) are mixed first, stirred, controlled at 50-70 deg.C, sodium carbonate solution (concentration 25% w/w, prepared by adding water 110g sodium carbonate) is added dropwise at uniform speed by a peristaltic pump, the flow rate is set, and the addition of sodium carbonate solution is controlled to be finished within 1.5 hours. After the reaction is finished, acid, alkali and high-temperature curing are carried out to obtain stable ferric carboxymaltose solution, and 160ml of absolute ethyl alcohol is added to separate out the ferric carboxymaltose.
Example 5
The carboxymaltodextrin solution was prepared as in example 1.
The carboxyl maltodextrin solution and ferric chloride solution (ferric chloride concentration 75% w/w, prepared by adding water 220g ferric chloride hexahydrate) are mixed first, stirred, the temperature is controlled at 50-70 ℃, sodium carbonate solution (concentration 25% w/w, prepared by adding water 110g sodium carbonate) is added dropwise at uniform speed by a peristaltic pump, the flow rate is set, and the addition of the sodium carbonate solution is finished within 2.0 hours. After the reaction is finished, acid, alkali and high-temperature solidification are carried out to obtain stable carboxyl maltose iron solution, and then 160ml of absolute ethyl alcohol is added to separate out the carboxyl maltose iron.
Example 6
The carboxymaltodextrin solution was prepared as in example 1.
The carboxyl maltodextrin solution and ferric chloride solution (ferric chloride concentration 75% w/w, prepared by adding water 220g ferric chloride hexahydrate) are mixed first, stirred, controlled at 50-70 deg.C, sodium carbonate solution (concentration 25% w/w, prepared by adding water 110g sodium carbonate) is added dropwise at uniform speed by a peristaltic pump, the flow rate is set, and the addition of sodium carbonate solution is controlled to be completed within 3.0 hours. After the reaction is finished, acid, alkali and high-temperature curing are carried out to obtain stable ferric carboxymaltose solution, and 160ml of absolute ethyl alcohol is added to separate out the ferric carboxymaltose.
TABLE 1 influence of the Uniform dropping time on the molecular weight of iron carboxymaltose under the same sodium carbonate dosage
Combining table 1 and fig. 1, it can be seen that, under the condition that the mass ratio of ferric trichloride to sodium carbonate is maintained unchanged, the molecular weight of ferric carboxymaltose and the uniform speed dripping time of sodium carbonate solution are in a linear relationship: y =25185x +77862 2 =0.9919, wherein y represents a weight average molecular weight of carboxymaltose iron, and x represents a dropping time of the sodium carbonate solution.
Example 7
On the basis of example 1, the respective materials were enlarged by a factor of 5.
Adding 1000ml of water into 500g of maltodextrin, stirring and dissolving, adding a sodium hydroxide solution, adjusting the pH value of the maltodextrin solution to 9.0-11.0, controlling the temperature to be 25-40 ℃, and adding 400g of a 10% sodium hypochlorite solution under stirring to obtain a carboxyl maltodextrin solution.
Mixing the carboxymaltodextrin solution with a ferric chloride solution (prepared by adding water to 1100g of ferric chloride hexahydrate) at a concentration of 75% w/w, stirring, controlling the temperature at 50-70 deg.C, adding a sodium carbonate solution (prepared by adding water to 550g of sodium carbonate at a concentration of 25% w/w) at a constant speed by a peristaltic pump, setting the flow rate, and controlling the addition of the sodium carbonate solution at 1.0 hour. After the reaction is finished, acid, alkali and high-temperature curing are carried out to obtain stable ferric carboxymaltose solution, and 800ml of ethanol is added to separate out ferric carboxymaltose.
Example 8
On the basis of example 1, the respective materials were enlarged by a factor of 10.
1000g of maltodextrin was dissolved in 2000ml of water under stirring. Adding sodium hydroxide solution, adjusting the pH value of the maltodextrin solution to 9.0-11.0, controlling the temperature to be 25-40 ℃, and adding 800g of 10% sodium hypochlorite solution under the stirring condition to obtain the carboxyl maltodextrin solution.
The carboxyl maltodextrin solution and ferric chloride solution (ferric chloride concentration 75% w/w, prepared by adding water 2200g ferric chloride hexahydrate) were mixed, stirred, controlled at 50-70 deg.C, sodium carbonate solution (concentration 25% w/w, prepared by adding water 1100g sodium carbonate) was added dropwise at uniform speed by peristaltic pump, the flow rate was set, and the addition of sodium carbonate solution was completed within 1.0 hour. After the reaction is finished, the stable ferric carboxymaltose solution is obtained after acid, alkali and high-temperature solidification, and 1600ml of ethanol is added to separate out the ferric carboxymaltose.
Example 9
On the basis of example 1, the individual materials were enlarged by a factor of 20.
2000g of maltodextrin was dissolved in 4000ml of water with stirring. Adding sodium hydroxide solution, adjusting the pH value of the maltodextrin solution to 9.0-11.0, controlling the temperature to be 25-40 ℃, and adding 1600g of 10% sodium hypochlorite solution under the stirring condition to obtain the carboxyl maltodextrin solution.
The carboxyl maltodextrin solution and ferric chloride solution (ferric chloride concentration 75% w/w, prepared by adding water 4400g of ferric chloride hexahydrate) are mixed firstly, stirred, the temperature is controlled to be 50-70 ℃, sodium carbonate solution (concentration 25% w/w, prepared by adding water 2200g of sodium carbonate) is added dropwise at uniform speed by a peristaltic pump, the flow rate is set, and the addition of the sodium carbonate solution is finished within 1.0 hour. After the reaction is finished, the stable ferric carboxymaltose solution is obtained after acid, alkali and high-temperature solidification, and 3200ml of ethanol is added to separate out the ferric carboxymaltose.
TABLE 2 influence of different batches on the molecular weight of carboxymaltose iron under the same sodium carbonate solution drop-adding time at uniform speed
As can be seen from Table 2 and FIG. 2, the molecular weight of the iron carboxymaltose is independent of the amount of the reactants, i.e., the molecular weight of the final iron carboxymaltose is not significantly different between the small batch and the large batch of reactants under the conditions required by the present invention.
Example 10
The carboxymaltodextrin solution was prepared as in example 1.
Ferric chloride solution: 220g of ferric trichloride hexahydrate and water are added to prepare a 75% (w/w) solution.
Sodium carbonate solution: 110g of sodium carbonate and water are added to prepare a 25% (w/w) solution.
Mixing the carboxyl maltodextrin solution and the ferric trichloride solution, stirring, controlling the temperature to be 50-70 ℃, and randomly dripping the sodium carbonate solution, wherein the dripping is finished within 1.0 hour. After the reaction is finished, acid, alkali and high-temperature solidification are carried out to obtain stable carboxyl maltose iron solution, and then 160ml of absolute ethyl alcohol is added to separate out the carboxyl maltose iron.
Sodium carbonate solution addition scheme 1: the sodium carbonate solution is dripped for half an hour at a dripping speed of 350g/h at a constant speed, and then the dripping speed is adjusted to 200g/h at a constant speed for half an hour. The weight average molecular weight of the iron carboxymaltose is 147306 and the molecular weight distribution coefficient is 1.82.
Sodium carbonate solution addition scheme 2: the sodium carbonate solution is dripped at the dripping speed of 420g/h for 20 minutes at a constant speed, the dripping is stopped for 10 minutes, and the dripping speed is adjusted to be 270g/h for 30 minutes at a constant speed. The weight average molecular weight of the carboxyl ferric maltose is 169685, and the molecular weight distribution coefficient is 1.10.
From this, it is understood that although the completion time of the dropping of the sodium carbonate solution was the same as that of example 3, the molecular weight of the final product was greatly different due to the random dropping even though the other conditions were completely the same.
Claims (2)
1. A preparation method of carboxyl ferric maltose is characterized in that in a mixed system of a carboxyl maltodextrin solution and a ferric trichloride solution, a sodium carbonate solution is added at a constant speed within 0.3-4 hours, and the carboxyl ferric maltose with target molecular weight and molecular weight distribution coefficient is obtained by controlling the adding speed of the sodium carbonate solution;
wherein the weight ratio of carboxyl maltodextrin calculated by raw material maltodextrin to ferric trichloride calculated by ferric trichloride hexahydrate is 100;
the mass ratio of ferric trichloride to sodium carbonate is (1-3);
the concentration of ferric trichloride in the ferric trichloride solution is 70-80% (w/w);
the concentration of sodium carbonate in the sodium carbonate solution is 20-35% (w/w);
the weight-average molecular weight of the carboxyl maltose iron is 100000-230000, and the molecular weight distribution coefficient is 1.35-1.55;
the DE value of maltodextrin is 10-15.
2. The method for preparing carboxymaltodextrin iron as claimed in claim 1, wherein the carboxymaltodextrin solution and the ferric chloride solution are mixed uniformly, the temperature is kept at 50-70 ℃, and the sodium carbonate solution is added into the mixed system at a constant speed under stirring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911327843.1A CN113004428B (en) | 2019-12-20 | 2019-12-20 | Preparation method of carboxyl ferric maltose |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911327843.1A CN113004428B (en) | 2019-12-20 | 2019-12-20 | Preparation method of carboxyl ferric maltose |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113004428A CN113004428A (en) | 2021-06-22 |
| CN113004428B true CN113004428B (en) | 2023-02-03 |
Family
ID=76381796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911327843.1A Active CN113004428B (en) | 2019-12-20 | 2019-12-20 | Preparation method of carboxyl ferric maltose |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113004428B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115403675A (en) * | 2022-08-29 | 2022-11-29 | 滨州学院 | Complexing and refining process of ferric carboxymaltose |
| CN115322265A (en) * | 2022-08-29 | 2022-11-11 | 滨州学院 | Carboxyl maltose controlled oxidation and purification process |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2496595A2 (en) * | 2009-11-04 | 2012-09-12 | Symed Labs Limited | Process for the preparation of iron (iii) carboxymaltose complex |
| IT1405688B1 (en) * | 2010-06-09 | 2014-01-24 | Biofer Spa | NEW COMPLEXES AT LOW MOLECULAR WEIGHT BETWEEN IRON AND MALTOBIONIC ACID, USE OF THESE FOR INTRAMUSCULAR OR SUBCUTANEOUS ADMINISTRATION IN ANEMIC STATE THERAPY, AND NEW PHARMACEUTICAL COMPOSITIONS SUITABLE FOR THESE USES. |
| CN108129582A (en) * | 2016-12-01 | 2018-06-08 | 江苏奥赛康药业股份有限公司 | A kind of preparation method of iron carbohydrate compound |
| CN106940348A (en) * | 2016-12-20 | 2017-07-11 | 南京艾德凯腾生物医药有限责任公司 | It is a kind of to determine carboxyl maltose iron molecule amount and its method for distribution |
| CN106977621A (en) * | 2017-02-15 | 2017-07-25 | 广州仁恒医药科技股份有限公司 | A kind of preparation method of carboxyl maltose iron |
| CN108498539A (en) * | 2018-05-03 | 2018-09-07 | 东营天东制药有限公司 | A kind of preparation method of water solubility chalybeate complex bulk pharmaceutical chemicals |
-
2019
- 2019-12-20 CN CN201911327843.1A patent/CN113004428B/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 羧基麦芽糖铁制备工艺研究;赵维等;《浙江化工》;20181115(第11期);全文 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113004428A (en) | 2021-06-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN113004428B (en) | Preparation method of carboxyl ferric maltose | |
| Chen et al. | Size-controlled synthesis of Ru nanoparticles by ethylene glycol reduction | |
| EP3127911A1 (en) | Preparation process and product of dialkyl phosphinate | |
| CN102010618B (en) | Method for preparing encapsulated red phosphorus | |
| CN108658047B (en) | Method for preparing high-content nano magnesium peroxide by one-pot precipitation method and product thereof | |
| CN105754333B (en) | A kind of selective laser sintering nylon powder and preparation method thereof | |
| CN114249844B (en) | Polysaccharide iron with controllable molecular weight and preparation method thereof | |
| CN110028672B (en) | Comb-shaped polythioether compound containing sulfur, nitrogen and oxygen atoms, and synthetic method and application thereof | |
| CN102690389B (en) | Preparation method for high molecular weight cationic polyacrylamide | |
| CN109179507B (en) | Slow-release long-acting nano antibacterial material and preparation and application methods thereof | |
| CN113261566B (en) | Preparation method of basic magnesium hypochlorite loaded metal organic framework bacteriostatic agent | |
| CN103936939A (en) | Interpenetrating polymer network core-shell emulsion and preparation method thereof | |
| CN110102772A (en) | A kind of high pressure hydro-thermal method that the reaction temperature being used to prepare noble metal nano particles is controllable | |
| CN108220946A (en) | The method that the processing of rare earth permanent magnet powder room temperature blackening improves antioxygenic property | |
| CN110510592B (en) | Method for regulating and preparing hydroxyapatite with excellent cell compatibility | |
| CN111732087A (en) | Europium-selenium double-doped hydroxyapatite and application thereof in preparing medicine for monitoring and treating osteosarcoma | |
| CN117843819A (en) | Preparation method of ferric carboxymaltose | |
| CN103497328B (en) | A kind of production technique of poly(isophthaloyl metaphenylene diamine) polymkeric substance | |
| CN214598936U (en) | PH adjusting device for alkaline material neutralization reaction | |
| CN108187136A (en) | A kind of preparation method of nanometer of load zinc hydroxyapatite | |
| KR20130043462A (en) | Synthesis of gold nanoparticles comprising control method of gold nanoparticle size | |
| CN102428961B (en) | Method for preparing nano MgO sustained-release sterilizing granules | |
| CN108030947B (en) | A kind of preparation method of modified negative oxygen ion powder | |
| CN109836614A (en) | Composite thermal stabilizer, the method for lactide ring-opening polymerisation production polylactic acid and polylactic acid and application | |
| CN112142996A (en) | Preparation method and application of modified polyester master batch |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |