CN112972799B - Combined treatment device for skin wounds - Google Patents
Combined treatment device for skin wounds Download PDFInfo
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- CN112972799B CN112972799B CN202110314928.7A CN202110314928A CN112972799B CN 112972799 B CN112972799 B CN 112972799B CN 202110314928 A CN202110314928 A CN 202110314928A CN 112972799 B CN112972799 B CN 112972799B
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- 206010072170 Skin wound Diseases 0.000 title claims abstract description 62
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Images
Classifications
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- A61F13/05—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H33/00—Bathing devices for special therapeutic or hygienic purposes
- A61H33/14—Devices for gas baths with ozone, hydrogen, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02N—ELECTRIC MACHINES NOT OTHERWISE PROVIDED FOR
- H02N1/00—Electrostatic generators or motors using a solid moving electrostatic charge carrier
- H02N1/04—Friction generators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H33/00—Bathing devices for special therapeutic or hygienic purposes
- A61H33/14—Devices for gas baths with ozone, hydrogen, or the like
- A61H2033/143—Devices for gas baths with ozone, hydrogen, or the like with oxygen
Abstract
The invention discloses a combined treatment device for skin wounds, and belongs to the field of skin wound repairers. Skin wound is with jointly treating device includes negative pressure drainage ware and friction nanometer generator, the negative pressure drainage ware includes air pump and has the enclosed type dressing of deformability, the enclosed type dressing with the air pump links to each other, the air pump is bled according to a plurality of predetermined time quantum and is aerifyd the drive the enclosed type dressing carries out rhythmical contraction and relaxation, friction nanometer generator implant extremely in the enclosed type dressing. The combined treatment device for the skin wound collects mechanical energy in the drainage and oxygenation processes in the negative pressure drainage device through the friction nano generator, realizes stable output electric stimulation of the friction nano generator, skillfully realizes the fusion of three wound diagnosis and treatment means of negative pressure drainage, oxygenation and electric stimulation, and realizes wound triple treatment.
Description
Technical Field
The invention relates to the field of skin wound repairers, in particular to a combined treatment device for skin wounds.
Background
The Vacuum Sealing Drainage technology (VSD) is a technology widely applied to wound treatment in clinic in recent years, and has the advantages of simple and controllable operation, promotion of wound healing, sustainable absorption of wound exudate, avoidance of cross contamination of infection sources and the like. Electrical Stimulation (ES) is an effective adjunct to wound care, which can stably enhance or mimic the endogenous electric field generated after trauma to promote wound repair. Therefore, in clinical medical practice or experimental research, the two are often combined and applied to the treatment of large-area wound surfaces to accelerate wound surface repair. The existing negative pressure closed drainage equipment and the existing electric stimulator are two sets of independent systems, so that the operation of VSD and ES combined treatment is very complicated, particularly, the electric stimulator usually adopts a commercial power supply, not only is complex in operation and maintenance, but also is large in size and not beneficial to carrying, is not beneficial to the activity of a patient and is difficult to meet the treatment requirement of a family.
Chinese patent document publication No. CN110201301B discloses a wound healing device based on friction power generation, which comprises a friction nano-generator, a rectifying and boosting circuit and a wound treatment assembly connected in sequence; the wound treatment assembly comprises a microplasma wound healing unit and an electrical stimulation wound healing unit mounted within the housing; the micro-plasma wound healing unit comprises a first electrode layer, an insulating layer and a second electrode layer, wherein the first electrode layer, the insulating layer and the second electrode layer are sequentially stacked, and the insulating layer and the second electrode layer are arranged at intervals; the first electrode layer and the second electrode layer are respectively connected with the positive electrode output end and the negative electrode output end of the alternating current booster circuit; the electric stimulation wound healing unit comprises two electrode strips which are symmetrically positioned on two sides of the bottom of the shell and are respectively connected with the positive and negative output ends of the rectification and voltage stabilization circuit, and the surfaces of the two electrode strips are both covered with a silica gel layer. Although the patent document mentions that the friction nano generator is used for wound healing, it needs to obtain a rotation speed by additionally providing mechanical energy input such as a hand-operated rotating shaft or a motor connecting rotating shaft, during the rotation of the rotor, the first friction plate is in alternate frictional contact with the second friction plate corresponding to the first and second electrode plates, so as to generate charge transfer, establish a high-voltage electric field, and induce the charge to be transferred between the first and second electrode plates through a load. Therefore, the wound healing device based on the friction power generation is complex in power supply and poor in use convenience.
Disclosure of Invention
In order to overcome the defects of the prior art, the technical problem to be solved by the invention is to provide a combined treatment device for skin wounds, mechanical energy in the drainage and oxygenation processes in a negative pressure drainage device is collected through a friction nano generator implanted in a dressing, stable output electric stimulation of the friction nano generator is realized, the fusion of three wound diagnosis and treatment means of negative pressure drainage, oxygenation and electric stimulation is ingeniously realized, and the wound triple treatment is realized.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a combined treatment device for skin wounds, which comprises a negative pressure drainage device and a friction nano generator, wherein the negative pressure drainage device comprises an air pump and a closed dressing with deformation capacity, the closed dressing is connected with the air pump, the air pump is used for pumping air and inflating according to a plurality of preset time periods to drive the closed dressing to perform rhythmic contraction and relaxation, the friction nano generator is implanted into the closed dressing, and the friction nano generator converts mechanical energy generated by the contraction and relaxation of the closed dressing into electric energy and outputs electric stimulation in the process of rhythmic contraction and relaxation.
The invention is further technically characterized in that the closed dressing comprises a film with single-side viscosity and a dressing body, the film is attached to an attached object to form a sealed cavity capable of containing the dressing body, the dressing body is arranged in the sealed cavity, and an air pump is communicated with the sealed cavity through a pipeline.
The invention is further technically characterized in that the negative pressure drainage device further comprises a negative pressure tube and an inflation tube, the air pump is configured to be a negative pressure pump and an inflation pump, the negative pressure pump is communicated with the closed dressing through the negative pressure tube, and the inflation pump is communicated with the closed dressing through the inflation tube.
The negative pressure drainage device is further technically characterized by further comprising a reversing valve, a negative pressure pipe and an inflation pipe, wherein the air pump is configured into a positive and negative pressure dual-purpose pump, the positive and negative pressure dual-purpose pump is connected with the reversing valve, a first interface of the reversing valve is communicated with the closed dressing through the negative pressure pipe, and a second interface of the reversing valve is communicated with the closed dressing through the inflation pipe.
The invention is further technically characterized by also comprising a drainage tank, wherein the negative pressure pipe comprises a first negative pressure pipe and a second negative pressure pipe, the negative pressure pump is connected with a first interface of the drainage tank through the first negative pressure pipe, and a second interface of the drainage tank is communicated with the closed dressing; or the first interface of the reversing valve is connected with the first interface of the drainage tank through a first negative pressure pipe, and the second interface of the drainage tank is communicated with the closed dressing.
The invention is further technically characterized in that the film in the closed dressing is provided with suckers corresponding to the negative pressure tube and the inflation tube, and the negative pressure tube and the inflation tube are communicated with the closed dressing through the suckers corresponding to the negative pressure tube and the inflation tube.
The invention is further technically characterized by further comprising a rectifying circuit for rectifying the pulse generated by the friction nano generator into the pulse for electric stimulation, wherein the friction nano generator is electrically connected with the rectifying circuit.
The invention is further technically characterized by also comprising a sealing package, wherein the rectifying circuit and the friction nano generator are arranged in the sealing package, and the sealing package is fixed in the sealing dressing.
The invention is further technically characterized by also comprising an annular electrode attached to the periphery of the wound edge of the attached object and a point-shaped electrode attached to the center of the wound surface of the attached object, wherein the annular electrode is electrically connected with the positive electrode or the negative electrode of the rectifying circuit, and the corresponding point-shaped electrode is electrically connected with the negative electrode or the positive electrode of the rectifying circuit.
The invention is further technically characterized by also comprising an air filter, wherein the air filter is communicated with the air pump, and the air filter is fixed at the air inlet of the air pump.
The invention is further technically characterized in that the output voltage and current of the friction nano generator are adjusted through the working period of air suction and air inflation.
The invention has the beneficial effects that:
according to the combined treatment device for the skin wound, the negative pressure drainage device is combined with the friction nano generator, so that mechanical energy in the rhythmic contraction and relaxation process of the closed dressing is converted into electric energy of the friction nano generator, electric stimulation is output after rectification by the rectification module, three wound diagnosis and treatment means of negative pressure drainage, oxygenation and electric stimulation are ingeniously fused, and triple treatment of the wound is achieved. The self-generating therapeutic system is composed of the closed dressing, the friction nano generator, the rectifying module and the electrodes, and the problem that the friction nano generator needs an external driving part to provide energy is solved. The closed dressing reasonably sets regular contraction and relaxation cycles, can realize effective cooperation of negative pressure drainage and electrical stimulation, outputs electrical stimulation with preset frequency, can provide proper oxygen supply for the skin wound surface in the relaxation process, and does not need external oxygen generation or supply equipment when implementing a normal oxygen supply mode of skin wound surface diagnosis and treatment. The low-intensity low-frequency unidirectional pulse generated by the friction nano power generation and rectification module can promote the directional migration of Hacat cells and the repair of a large-area wound surface. An external driving part for friction nano power generation is cancelled, and the friction nano power generation is selectively implanted into the closed dressing, so that the volume of the combined treatment device is greatly reduced, and the combined treatment device is more portable.
Drawings
FIG. 1 is a schematic view of the structure of a combined treatment apparatus for skin wounds, provided in one embodiment of the present invention;
FIG. 2 is a schematic cross-sectional view of an enclosed dressing provided in a first embodiment of the present invention;
FIG. 3 is a bottom view of an occlusive dressing provided in one embodiment of the present invention, without an adherend;
FIG. 4 is a schematic structural diagram of a triboelectric nanogenerator provided in a first embodiment of the invention;
FIG. 5 is a schematic structural diagram of a triboelectric nanogenerator provided in a second embodiment of the invention;
FIG. 6 is a comparison of the healing rates of the A, B set of comparative experiments provided in an embodiment of the present invention;
FIG. 7 is a graph of the cell migration trajectories for a group A assay provided in an embodiment of the present invention;
FIG. 8 is a graph of the cell migration trajectory for the group C assay provided in an embodiment of the present invention, wherein the cycle of evacuation and inflation is: pumping air for 1s, and inflating air for 1 s;
FIG. 9 is a graph of the cell migration trajectories for the group B experiments provided in the present embodiment, wherein the duty cycle of air pumping and air charging is: pumping air for 3s and inflating air for 1 s;
FIG. 10 is a graph of the output voltage waveform of a group C test provided in an embodiment of the present invention;
FIG. 11 is a graph of the output current waveform of a group C test provided in an embodiment of the present invention;
FIG. 12 is a graph of the output voltage waveforms of the group B tests provided in this embodiment of the present invention;
fig. 13 is a graph of output current waveforms for a group B test provided in an embodiment of the present invention.
In the figure: 2. an occlusive dressing; 3. a friction nanogenerator; 4. sealing the cavity; 21. a film; 22. a dressing body; 13. a negative pressure tube; 14. an inflation tube; 11. a negative pressure pump; 12. a booster pump; 40. a suction cup; 6. an attached object; 7. a drainage tank; 131. a first negative pressure tube; 132. a second negative pressure tube; 8. a rectifying circuit; 31. a first friction layer; 32. a second friction layer; 33. a first electrode layer; 34. a second motor layer; 35. an isolation layer; 36. a support layer; 8. a rectifying circuit; 9. sealing and packaging; 10. a ring-shaped electrode; 20. a dot-shaped electrode; 30. an air filter; 15. a diverter valve; 16. a positive and negative pressure dual-purpose pump.
Detailed Description
The technical scheme of the invention is further explained by the specific implementation mode in combination with the attached drawings.
Example one
As shown in fig. 1 to 4, the combined treatment device for skin wounds provided in this embodiment is used for negative pressure drainage and oxygenation and electrical stimulation combined treatment of large-area wounds, and includes a negative pressure drainage device and a friction nano-generator 3, where the negative pressure drainage device includes an air pump and an enclosed dressing 2 with deformation capability. The closed dressing 2 refers to a dressing body 22 with the capability of deformation placed inside the sealed cavity 4, for example: the dressing body 22 with the deformation capacity is wrapped on a flat surgical drainage tube, one end wrapped with the dressing body 22 is placed at the wound, and a transparent sealing film is covered to form the closed dressing 2. The closed dressing 2 is connected with an air pump, the air pump is used for pumping air according to a plurality of preset time periods and inflating the air pump to drive the closed dressing 2 to perform rhythmic contraction and relaxation, and the preset time periods can be periodic or a plurality of time periods reasonably determined according to skin recovery conditions or different electric stimulation requirements. The friction nanometer generator 3 is implanted into the closed dressing 2, and in the process that the closed dressing 2 performs rhythmic contraction and relaxation, the friction nanometer generator 3 located in the closed dressing 2 converts mechanical energy generated by contraction and relaxation of the closed dressing 2 into electric energy and outputs electric stimulation. The shape-changing capability means that the closed dressing 2 can generate electric stimulation through rhythmic contraction and relaxation of the closed dressing 3. When the closed dressing device works specifically, the air pump drives the closed dressing 2 to perform rhythmic contraction and relaxation for a plurality of preset time periods, and the friction nanometer generator 3 converts mechanical energy generated by the contraction and relaxation of the closed dressing 2 into electric energy and outputs rhythmic electric stimulation.
In order to realize that air pump drive dressing 2 contracts and diastole, furtherly, enclosed type dressing 2 is including film 21 and the dressing body 22 that have the unilateral stickness, dressing body 22 refers to medical dressing commonly used, the film 21 that have the unilateral stickness is attached and is formed the seal chamber 4 that can hold dressing body 22 on being attached 6, dressing body 22 is arranged in seal chamber 4, the air pump passes through the pipeline and is linked together with seal chamber 4, it usually indicates human wound skin or is used for experimental simulation wound skin etc. to be attached 6. In practice, the dressing body 22 is preferably applied to the wound site, and the single-sided adhesive film 21 is preferably adhered to the normal skin to effect sealing. When the air pump pumps air or inflates air to the sealed cavity 4, the dressing body 22 in the sealed cavity can contract and relax rhythmically. Preferably, the dressing body 22 is configured as a foam dressing, and further, the dressing body 22 is configured as a polyurethane foam dressing, which has good biocompatibility and stronger deformation capability in the air suction or inflation process, and can still be tightly attached to the wound surface when the internal pressure is small, that is, the wound sheet has good fitting performance, and meanwhile, the foam structure of the dressing can better absorb the exudate at the skin of the wound surface of a human body, and meanwhile, the polyurethane foam dressing provides a good microenvironment for wound surface healing.
In order to enable the dressing 2 to perform rhythmic contraction and relaxation, the negative pressure drainage device further comprises a negative pressure tube 13 and an inflation tube 14, the air pump is configured to be a negative pressure pump 11 and a booster pump 12, the negative pressure pump 11 is communicated with the closed dressing 2 through the negative pressure tube 13 and transmits negative pressure into the sealed cavity 4 of the closed dressing 2, and the booster pump 12 is communicated with the closed dressing 2 through the inflation tube 14 and transmits pressurization into the sealed cavity 4 of the closed dressing 2. Further preferably, the film 21 is provided with a suction cup 40 corresponding to the negative pressure tube 13 and the inflation tube 14, and the negative pressure tube 13 and the inflation tube 14 are communicated with the sealed cavity 4 through the suction cups 40 corresponding to the negative pressure tube 13 and the inflation tube 14. During specific work, the negative pressure pump 11 generates negative pressure through the negative pressure pipe 13, so that the closed dressing 2 is in a contraction state, the booster pump 12 generates boosting pressure through the inflation pipe 14, so that the closed dressing 2 is in a relaxation state, the actions are repeated in a plurality of preset time periods, the rhythmic contraction and relaxation of the dressing 2 can be realized, the output electrical stimulation of the rhythmic performance of the friction nano generator 3 is realized, and the purpose of combined treatment is achieved.
In order to drain the exudate generated by the skin wound, further, the combined treatment device for the skin wound further comprises a drainage tank 7, the negative pressure tube 13 comprises a first negative pressure tube 131 and a second negative pressure tube 132, the negative pressure pump 11 is connected with a first interface of the drainage tank 7 through the first negative pressure tube 131, and a second interface of the drainage tank 7 is communicated with the closed dressing 2 through the second negative pressure tube 132. Under the action of the negative pressure pump 11, the exudate and the negative pressure gas generated by the skin wound surface flow into the drainage tank 7 through the second negative pressure tube 132, at this time, the exudate generated by the skin wound surface is heavier than the negative pressure gas, and then falls into the drainage tank 7 for storage, the negative pressure gas continues to enter the negative pressure pump 11 along the first negative pressure tube 131, and then the exudate generated by the skin wound surface is prevented from being sucked back into the negative pressure pump 11 because the negative pressure pump 11 is discharged, so that the drainage tank 7 can be used for preventing the exudate generated by the skin wound surface from being sucked back into the negative pressure pump 11.
In order to rectify the electricity generated by the friction nano-generator 3, it is preferable that the skin wound combination therapy device further includes a rectification circuit 8, the rectification circuit 8 is configured to rectify the pulse generated by the friction nano-generator 3 into a pulse for electrical stimulation, and the friction nano-generator 3 is electrically connected to the rectification circuit 8. The rectifying circuit 8 is configured as a circuit consisting of at least one rectifying bridge, which is capable of rectifying the bidirectional pulse current generated by the friction nano-generator 3 into a unidirectional pulse current in order to better meet the requirements of the electrical stimulation. The friction nanogenerator 3 is configured as a contact separation type friction nanogenerator, the friction nanogenerator 3 includes a first friction layer 31, a second friction layer 32, a first electrode layer 33 and a second motor layer 34, a friction surface of the first friction layer 31 and a friction surface of the second friction layer 32 are disposed opposite to each other with a predetermined gap therebetween, and the first electrode layer 33 and the second motor layer 34 are made of a metal conductive material, for example: the first electrode layer 33 and the second electrode layer 34 may be configured as Cu tapes or Au or Cu thin electrode layers obtained by a metal magnetron sputtering process. The first electrode layer 33 is located on the outer side of the first friction layer 31, i.e. the upper surface of the first friction layer 31 in the figure, and the second electrode layer 34 is located on the outer side of the second friction layer 32, i.e. the lower surface of the second friction layer 32 in the figure, when the closed dressing 2 contracts, the first friction layer 31 and the second friction layer 32 are continuously pressed, so that the friction surfaces of the first friction layer 31 and the second friction layer 32 are continuously rubbed with each other to generate charges, and when the closed dressing 2 expands, the first friction layer 31 and the second friction layer 32 are separated due to a preset gap, so that the charges generated by the first friction layer 31 and the second friction layer 32 cannot be completely neutralized to form a potential difference. In order to provide a reasonable predetermined gap between the friction surface of the first friction layer 31 and the friction surface of the second friction layer 32 of the friction nanogenerator 3, it is further preferable that the friction nanogenerator 3 further includes an isolation layer 35, the isolation layer 35 is located between the first friction layer 31 and the second friction layer 32 and at the edge of the first friction layer 31 and the second friction layer 32, and the predetermined gap between the first friction layer 31 and the second friction layer 32 can be adjusted by reasonably setting the thickness of the isolation layer 35. In order to increase the hardness of the first friction layer 31, it is further preferred that the friction nanogenerator 3 further comprises a support layer 36, the support layer 36 is disposed between the first friction layer 31 and the first electrode layer 33, and the support layer 36 is configured as an insulating material, such as: the support layer 36 is configured as a 0.15mm-0.2mm thick PET or Kapton sheet. Further preferably, the friction surface of the first friction layer 31 and the friction surface of the second friction layer 32 are polished by using sand paper, and the roughness of the friction surface of the first friction layer 31 and the roughness of the friction surface of the second friction layer 32 can be increased by polishing the sand paper, so that the contact area between the two is increased, and the friction power generation effect of the friction nano-generator 3 is improved.
In order to avoid damage to the friction nanogenerator 3 and the rectifying circuit 8 by exudates generated on the skin wound surface, the skin wound combined treatment device further comprises a sealing package 9, the rectifying circuit 8 and the friction nanogenerator 3 are arranged in the sealing package 9, the sealing package 9 is fixed in the closed dressing 2, the sealing package 9 is made of an insulating material, and the material of the sealing package 9 is preferably one or more of PTFE, Kapton and PET.
In order to apply the electricity generated by the friction nano generator 3 to the skin wound surface, the combined treatment device for skin wound further comprises an annular electrode 10 attached to the periphery of the wound edge of the attached object 6 and a point-shaped electrode 20 attached to the center of the wound surface of the attached object 6, wherein the annular electrode 10 is electrically connected with the positive electrode or the negative electrode of the rectifying circuit 8, and the corresponding point-shaped electrode 20 is electrically connected with the negative electrode or the positive electrode of the rectifying circuit 8. The annular electrode 10 and the point-like electrode 20 are made of metal materials with good biocompatibility, such as Au nanoparticles, silver nanowires or platinum, the annular electrode 10 and the point-like electrode 20 can be fixed on one surface of the closed dressing 2, which is in contact with a skin wound surface, through a chemical crosslinking or physical fixing method, the annular electrode 10 is preferably attached to normal skin, namely the diameter of the annular electrode 10 is larger than the maximum outer diameter of the skin wound surface, the point-like electrode 20 is preferably attached to the center of the wound surface of the skin wound surface, electricity generated by the friction nano generator 3 is rectified by the rectifying circuit 8 and then acts on the annular electrode 10 and the point-like electrode 20, and a directional electric field is generated between the annular electrode 10 and the point-like electrode 20 to form electric stimulation. In practical production, the types and shapes of the ring-shaped electrode 10 and the dot-shaped electrode 20 can be reasonably set according to the area of the skin wound, and the ring-shaped electrode 10 provided in this embodiment is annular and only aims at the circular skin wound.
In order to ensure that the gas entering the negative pressure drainage device is clean gas, further, the combined treatment device for skin wounds further comprises an air filter 30 or a clean gas source, the air filter 30 is communicated with the air pump, the air filter 30 is fixed at the air inlet of the air pump, when the air pump works, air can firstly pass through the air filter 30 to be filtered and then enters the air pump of the negative pressure drainage device, so that the gas flowing into the negative pressure drainage device is ensured to be clean gas, and secondary infection at wounds is avoided.
Example two
As shown in fig. 5, the combined treatment device for skin wounds provided in this embodiment includes a negative pressure drainage device and a friction nano-generator 3, the negative pressure drainage device includes an air pump and an enclosed dressing 2 having a deformation capability, the air pump is connected to the enclosed dressing 2, the air pump pumps air and inflates according to a plurality of preset time periods to drive the enclosed dressing 2 to perform rhythmic contraction and relaxation, the friction nano-generator 3 is implanted into the enclosed dressing 2, and during the rhythmic contraction and relaxation of the enclosed dressing 2, the friction nano-generator 3 located in the enclosed dressing 2 converts mechanical energy generated by the contraction and relaxation of the enclosed dressing 2 into electrical energy and outputs electrical stimulation.
The second embodiment is different from the first embodiment in that:
the combined treatment device for the skin wounds further comprises a reversing valve 15, the negative pressure drainage device comprises a negative pressure tube 13, an inflation tube 14 and the reversing valve 15, the air pump is configured to be a positive and negative pressure dual-purpose pump 16, the positive and negative pressure dual-purpose pump 16 is connected with the reversing valve 15, a first interface of the reversing valve 15 is communicated with the closed dressing 2 through the negative pressure tube 13, and a second interface of the reversing valve 15 is communicated with the closed dressing 2 through the inflation tube 14. Further preferably, a suction cup 40 corresponding to the negative pressure tube 13 and the inflation tube 14 is arranged on the closed dressing 2, and the negative pressure tube 13 and the inflation tube 14 are communicated with the closed dressing 2 through the suction cups 40 corresponding to the negative pressure tube 13 and the inflation tube 14. When the closed dressing 2 is in a diastolic state, the actions are repeated in a plurality of preset time periods, rhythmic contraction and diastole of the dressing 2 can be realized, rhythmic output electric stimulation of the friction nano generator 3 is realized, and the purpose of combined treatment is achieved. Further preferably, the combined treatment device for skin wounds further comprises a drainage tank 7, the negative pressure tube 13 comprises a first negative pressure tube 131 and a second negative pressure tube 132, the positive and negative pressure dual-purpose pump 16 is connected with the first interface of the drainage tank 7 through the first negative pressure tube 131, and the second interface of the drainage tank 7 is communicated with the closed dressing 2 through the second negative pressure tube 132. Under the action of the positive and negative pressure dual-purpose pump 16, the exudate and the negative pressure gas generated by the skin wound surface flow into the drainage tank 7 through the second negative pressure tube 132, at this time, the exudate generated by the skin wound surface is heavier than the negative pressure gas, and then falls into the drainage tank 7 for storage, and the negative pressure gas continues to enter the positive and negative pressure dual-purpose pump 16 along the first negative pressure tube 131, and then is discharged out of the positive and negative pressure dual-purpose pump 16.
The combined treatment device comprises a negative pressure drainage device and a friction nano generator 3, wherein the negative pressure drainage device comprises an air pump and an enclosed dressing 2 with deformation capacity. The closed dressing 2 refers to a dressing body 22 with the capability of deformation placed inside the sealed cavity 4, for example: the dressing body 22 with the deformation capacity is wrapped on a flat surgical drainage tube, one end wrapped with the dressing body 22 is placed at the wound, and a transparent sealing film is covered to form the closed dressing 2. The effective effect of the combined treatment apparatus for skin wounds provided in the present embodiment is further demonstrated by experiments, and is illustrated by taking the positive and negative pressure pump 16 as an example.
In the combined treatment device for skin wounds provided in this embodiment, the rectification circuit 8 and the friction nano-generator 3 are first placed in the sealing package 9, and then the sealing package 9 is implanted into the dressing body 22, and the annular electrode 10 is electrically connected with the rectification circuit 8 in the dressing body 22 in order for the point-like electrode 20 to be outside the dressing body 22. The dressing body 22 is placed inside the film 21 and fixed on normal skin on the periphery of the skin wound, the dressing body 22 is attached to the skin wound, and the film 21 and the normal skin form a sealed cavity 4 together with the skin wound after being attached. At this time, it should be noted that the ring-shaped electrode 10 is attached to the periphery of the wound edge of the skin wound surface, and the point-shaped electrode 20 is attached to the center of the wound surface of the skin wound surface. Illustratively, the specific use may be according to the following operation steps:
and step S00: taking a circular skin wound surface with the diameter of 4cm as an example, selecting a proper polyurethane foam dressing body 22 according to the size of the wound, wherein the size of the dressing body 22 is configured to be 15-20cm in length, 10-15cm in width and 2.5-4cm in height;
and S10: the friction nanometer generator 3 with the size of 3cm by 6cm by 0.2cm and the rectifying circuit 8 with the size of 0.5cm by 0.08cm are arranged in the sealed package 9, a cavity with the size of 3.5cm by 6.5cm by 0.4cm is drawn in the middle of the dressing body 22, the sealed package 9 is fixed in the dressing body 22, and the lead for connecting the annular electrode 10 and the point-shaped electrode 20 extends to the bottom of the dressing body 22;
and step S20: a ring electrode 10 with the inner diameter of 4.5cm and the outer diameter of 5.5cm and a point electrode 20 with the diameter of 0.2-0.5cm are fixed at the bottom of the dressing body 22, the point electrode 20 is arranged in the middle of the ring electrode 10, and the sealing package 9 is electrically connected with the ring electrode 10 and the point electrode 20 respectively through positive and negative leads;
and S30: after the dressing body 22 is sterilized and disinfected, the dressing body 22 is attached to the round skin wound surface through the film 21, and the size of the film 21 is larger than that of the dressing and can be completely sealed;
and step S40: two small holes are cut on the film 21, a negative pressure tube 13 and an inflation tube 14 which are connected with a positive and negative pressure dual-purpose pump 16 are attached to the two small holes through corresponding suction cups 40, the negative pressure tube 13 and the inflation tube 14 are communicated with the sealed cavity 4 of the film 21, and a drainage tank 7 is arranged on the passage of the negative pressure tube 13.
And step S50: the positive and negative pressure dual-purpose pump 16 is started, the positive and negative pressure dual-purpose pump 16 adopts the working mode of charging air for 1s and pumping air for 3s, namely the working frequency of the positive and negative pressure dual-purpose pump 16 is 0.25 Hz.
As shown in fig. 12 and 13, fig. 12 and 13 are waveforms of output voltage and current of the combined treatment device for skin trauma provided in this embodiment, and the rectifying circuit 8 rectifies the bidirectional pulse current generated by the friction nano-generator 3 into a unidirectional pulse current so as to better satisfy the requirement of electrical stimulation.
The effective effect of the combined treatment device for skin wounds provided in this example is further demonstrated below by comparative experiments, and the group a providing device is only a negative pressure drainage device (VSD); the device provided in group B is a combined treatment device for skin wounds (VSD-ES) provided in the application, and the work cycle of air suction and air inflation is as follows: pumping for 3s and inflating for 1 s; the device provided in group C is a combined treatment device for skin wounds (VSD-ES) according to the present application, and the duty cycle of air suction and air inflation is as follows: pumping air for 1s, and inflating for 1 s; group a had no electrical stimulation, while groups B and C had electrical stimulation. Referring to fig. 7, it is shown in fig. 7 that the wound healing speed of the group B is significantly better than that of the group a, and it is further proved that the combined treatment device for skin wounds provided by this embodiment enables three wound diagnosis and treatment means of negative pressure drainage, oxygenation and electrical stimulation to be ingeniously integrated, so that triple treatment of the wound is realized, and the curative effect of the combined treatment device is significantly better than that of a treatment device that only adopts a negative pressure drainage device (VSD). As can be seen from fig. 7, 8 and 9, fig. 7 is a diagram of the cell migration trajectory in the group a experiment provided in the embodiment of the present invention, and fig. 8 is a diagram of the cell migration trajectory in the group C experiment provided in the embodiment of the present invention, wherein the duty cycle of the air pumping and the air charging is: air suction 1s and air inflation 1s, fig. 9 is a diagram of the cell directional migration trajectory of the group B experiment provided in the embodiment of the present invention, wherein the duty cycle of air suction and air inflation is: air is pumped for 3s, and air is inflated for 1 s. The Hacat cell directional migration method has the advantages that a directional electric field is applied to Hacat cells for 3h, and the cell directional migration trace diagram of the group A is compared with the cell directional migration trace diagram of the group B and the cell directional migration trace diagram of the group C, so that the group B obviously promotes the directional migration of the cells, the directional migration effect of the cells is far better than that of the group A and the group C, and the directional migration effect of the cells is slightly better than that of the group A because the group C also has a small amount of electric stimulation, so that the working cycle of air suction and air inflation has an important influence on the strength of the generated electric stimulation, and the directional migration trace of the cells can be obviously influenced only when the electric stimulation has certain strength. As can be seen from comparing fig. 10 and 11 with fig. 12 and 13, the duty cycle of pumping and inflating is as follows: when the air is pumped for 3s and is inflated for 1s, the voltage and the current intensity output by the combined treatment device for the skin wounds are obviously increased, and the electrical stimulation effect is better.
While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the spirit and scope of the invention. The present invention is not to be limited by the specific embodiments disclosed herein, and other embodiments that fall within the scope of the claims of the present application are intended to be within the scope of the present invention.
Claims (13)
1. A combination treatment device for skin wounds, characterized by:
comprises a negative pressure drainage device and a friction nano generator;
the negative pressure drainage device comprises an air pump and a closed dressing with deformation capacity;
the closed dressing is connected with the air pump, the air pump is used for pumping air and inflating according to a plurality of preset time periods to drive the closed dressing to perform rhythmic contraction and relaxation, the friction nanometer generator is implanted into the closed dressing, and the friction nanometer generator converts mechanical energy generated by the contraction and relaxation of the closed dressing into electric energy and outputs electric stimulation in the process of performing the rhythmic contraction and relaxation of the closed dressing.
2. The combination treatment device for skin wounds according to claim 1, characterized in that:
the closed dressing comprises a film with single-side adhesion and a dressing body;
the film is attached to an attached object to form a sealed cavity capable of containing the dressing body, the dressing body is arranged in the sealed cavity, and the air pump is communicated with the sealed cavity through a pipeline.
3. The combination treatment device for skin wounds according to claim 1, characterized in that:
the negative pressure drainage device also comprises a negative pressure pipe and an inflation pipe;
the air pump is configured to be a negative pressure pump and an inflator pump, the negative pressure pump is communicated with the closed dressing through a negative pressure pipe, and the inflator pump is communicated with the closed dressing through an inflator pipe.
4. The combination treatment device for skin wounds according to claim 1, characterized in that:
the negative pressure drainage device also comprises a reversing valve, a negative pressure pipe and an inflation pipe;
the air pump is configured to be a positive-negative pressure dual-purpose pump, the positive-negative pressure dual-purpose pump is connected with the reversing valve, a first interface of the reversing valve is communicated with the closed dressing through a negative pressure pipe, and a second interface of the reversing valve is communicated with the closed dressing through an inflation pipe.
5. The combination treatment device for skin wounds according to claim 3, characterized in that:
also comprises a drainage tank;
the negative pressure pipe comprises a first negative pressure pipe and a second negative pressure pipe;
the negative pressure pump is connected with the first interface of the drainage tank through a first negative pressure pipe, and the second interface of the drainage tank is communicated with the closed dressing.
6. The combination treatment device for skin wounds according to claim 4, characterized in that:
also comprises a drainage tank;
the first interface of the reversing valve is connected with the first interface of the drainage tank through a first negative pressure pipe, and the second interface of the drainage tank is communicated with the closed dressing.
7. The combination therapy device for cutaneous wounds according to claim 3 or 4, characterized in that:
and suckers corresponding to the negative pressure tube and the inflation tube are arranged on the film in the closed dressing, and the negative pressure tube and the inflation tube are communicated with the closed dressing through the suckers corresponding to the negative pressure tube and the inflation tube.
8. The combination therapy device for skin wounds according to any one of claims 1 to 7, characterized in that:
the friction nano generator is electrically connected with the rectifying circuit.
9. The combination treatment device for skin wounds according to claim 8, characterized in that:
the friction nanometer generator is characterized by further comprising a sealing package, the rectifying circuit and the friction nanometer generator are arranged in the sealing package, and the sealing package is fixed in the closed dressing.
10. The combination therapy device for cutaneous wounds according to claim 8 or 9, characterized in that:
the wound surface treatment device is characterized by further comprising an annular electrode attached to the periphery of the wound edge of the attached object and a point-shaped electrode attached to the center of the wound surface of the attached object, wherein the annular electrode is electrically connected with the positive electrode of the rectifying circuit, and the corresponding point-shaped electrode is electrically connected with the negative electrode of the rectifying circuit.
11. The combination treatment device for skin wounds according to claim 1, characterized in that:
the air pump is communicated with the air pump, and the air filter is fixed at an air inlet of the air pump.
12. The combination treatment device for skin wounds according to claim 1, characterized in that:
the output voltage and current of the friction nano generator are adjusted through the working period of air suction and air inflation.
13. The combination treatment device for skin wounds according to claim 12, characterized in that:
when the air-assisted vehicle works, air is pumped for 3s, and air is inflated for 1 s.
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| CN114469518B (en) * | 2022-01-27 | 2023-02-21 | 长沙海润生物技术有限公司 | Dressing for negative-voltage electric field coupling strong-oxygen therapy |
| CN114533977B (en) * | 2022-02-21 | 2022-11-25 | 杭州整形医院有限公司 | Portable vacuum pump negative pressure scar therapeutic device |
| CN114712089B (en) * | 2022-04-25 | 2023-04-07 | 长沙海润生物技术有限公司 | Wound surface dressing for negative-pressure coupling electric field and constant-temperature treatment |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530361A (en) * | 2008-03-13 | 2009-09-16 | 泰科保健集团有限合伙公司 | Vacuum wound therapy wound dressing with variable performance zones |
| WO2009141820A1 (en) * | 2008-05-21 | 2009-11-26 | Morris Topaz | Wound healing device |
| CN101721741A (en) * | 2008-10-14 | 2010-06-09 | 孙建军 | Cytoskeleton for tissue-engineered tympanic membrane |
| KR101494213B1 (en) * | 2013-12-31 | 2015-02-17 | 연세대학교 산학협력단 | Self-powered generator, method for manufacturing the same and piezoelectric enery-harvesting device using the generator |
| CN104467516A (en) * | 2014-12-05 | 2015-03-25 | 天津理工大学 | Method for applying nano-silver to pole plate surface line control of mini-type frictional generator |
| EP3117807A1 (en) * | 2015-07-16 | 2017-01-18 | Carag AG | Multifunctional wound treatment dressing |
| CN110201301A (en) * | 2019-06-14 | 2019-09-06 | 清华大学 | A kind of wound healing device based on triboelectricity |
| CN209360990U (en) * | 2018-06-21 | 2019-09-10 | 昆明医科大学第二附属医院 | A kind of fixed device of the simple rat skin surface of a wound |
| CN111744023A (en) * | 2019-03-28 | 2020-10-09 | 华中科技大学 | Self-adhesive hydrogel patch with spontaneous electrical property and preparation method and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210060296A1 (en) * | 2018-03-28 | 2021-03-04 | Miraki Innovation Think Tank, Llc | Miniaturized intra-body controllable medical device |
-
2021
- 2021-03-24 CN CN202110314928.7A patent/CN112972799B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530361A (en) * | 2008-03-13 | 2009-09-16 | 泰科保健集团有限合伙公司 | Vacuum wound therapy wound dressing with variable performance zones |
| WO2009141820A1 (en) * | 2008-05-21 | 2009-11-26 | Morris Topaz | Wound healing device |
| CN101721741A (en) * | 2008-10-14 | 2010-06-09 | 孙建军 | Cytoskeleton for tissue-engineered tympanic membrane |
| KR101494213B1 (en) * | 2013-12-31 | 2015-02-17 | 연세대학교 산학협력단 | Self-powered generator, method for manufacturing the same and piezoelectric enery-harvesting device using the generator |
| CN104467516A (en) * | 2014-12-05 | 2015-03-25 | 天津理工大学 | Method for applying nano-silver to pole plate surface line control of mini-type frictional generator |
| EP3117807A1 (en) * | 2015-07-16 | 2017-01-18 | Carag AG | Multifunctional wound treatment dressing |
| CN209360990U (en) * | 2018-06-21 | 2019-09-10 | 昆明医科大学第二附属医院 | A kind of fixed device of the simple rat skin surface of a wound |
| CN111744023A (en) * | 2019-03-28 | 2020-10-09 | 华中科技大学 | Self-adhesive hydrogel patch with spontaneous electrical property and preparation method and application thereof |
| CN110201301A (en) * | 2019-06-14 | 2019-09-06 | 清华大学 | A kind of wound healing device based on triboelectricity |
Non-Patent Citations (1)
| Title |
|---|
| 自制负压装置联合纳米银敷料在手术切口感染中的应用;杨剑英，成沛玉，鄢碧玙，王薇，邹惠美;《当代护士》;20180301;第25卷(第9期);62-63 * |
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