CN112914099A - Anti-wrinkle composition for postpartum women and preparation method and application thereof - Google Patents
Anti-wrinkle composition for postpartum women and preparation method and application thereof Download PDFInfo
- Publication number
- CN112914099A CN112914099A CN202110155256.XA CN202110155256A CN112914099A CN 112914099 A CN112914099 A CN 112914099A CN 202110155256 A CN202110155256 A CN 202110155256A CN 112914099 A CN112914099 A CN 112914099A
- Authority
- CN
- China
- Prior art keywords
- postpartum women
- parts
- wrinkle composition
- folic acid
- wrinkle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001153 anti-wrinkle effect Effects 0.000 title claims abstract description 70
- 239000000203 mixture Substances 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title abstract description 16
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 27
- 108010010803 Gelatin Proteins 0.000 claims abstract description 26
- 239000008273 gelatin Substances 0.000 claims abstract description 26
- 229920000159 gelatin Polymers 0.000 claims abstract description 26
- 235000019322 gelatine Nutrition 0.000 claims abstract description 26
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 26
- 150000002224 folic acids Chemical class 0.000 claims abstract description 16
- 239000000706 filtrate Substances 0.000 claims description 50
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 41
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 40
- 238000001914 filtration Methods 0.000 claims description 34
- 239000011259 mixed solution Substances 0.000 claims description 27
- 241000125175 Angelica Species 0.000 claims description 26
- 239000000047 product Substances 0.000 claims description 22
- 230000001954 sterilising effect Effects 0.000 claims description 21
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 20
- 238000001035 drying Methods 0.000 claims description 20
- 239000011724 folic acid Substances 0.000 claims description 20
- 235000019152 folic acid Nutrition 0.000 claims description 20
- 229960000304 folic acid Drugs 0.000 claims description 20
- 238000002156 mixing Methods 0.000 claims description 20
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 19
- 235000013824 polyphenols Nutrition 0.000 claims description 19
- 238000005303 weighing Methods 0.000 claims description 19
- 239000000243 solution Substances 0.000 claims description 18
- 108010052008 colla corii asini Proteins 0.000 claims description 17
- 238000010438 heat treatment Methods 0.000 claims description 17
- 238000001816 cooling Methods 0.000 claims description 11
- 238000009835 boiling Methods 0.000 claims description 8
- 238000002844 melting Methods 0.000 claims description 8
- 230000008018 melting Effects 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 229940065207 methylfolic acid Drugs 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 239000000126 substance Chemical class 0.000 claims description 3
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims description 2
- 235000008191 folinic acid Nutrition 0.000 claims description 2
- 239000011672 folinic acid Substances 0.000 claims description 2
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 229960001691 leucovorin Drugs 0.000 claims description 2
- 244000269722 Thea sinensis Species 0.000 claims 3
- 241000382455 Angelica sinensis Species 0.000 claims 2
- 230000037303 wrinkles Effects 0.000 abstract description 13
- 230000036541 health Effects 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 6
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 206010040925 Skin striae Diseases 0.000 description 19
- 241001122767 Theaceae Species 0.000 description 16
- 230000000052 comparative effect Effects 0.000 description 14
- 239000003921 oil Substances 0.000 description 8
- 235000019198 oils Nutrition 0.000 description 8
- 230000037394 skin elasticity Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 230000008439 repair process Effects 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 235000021590 normal diet Nutrition 0.000 description 3
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 2
- 244000144725 Amygdalus communis Species 0.000 description 2
- 235000011437 Amygdalus communis Nutrition 0.000 description 2
- 241000213006 Angelica dahurica Species 0.000 description 2
- NRGONRDRXCPMIC-GDKBPFBDSA-N N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CC(C=O)C(O)=O)C(O)=O)C=C1 Chemical compound N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CC(C=O)C(O)=O)C(O)=O)C=C1 NRGONRDRXCPMIC-GDKBPFBDSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 241000304195 Salvia miltiorrhiza Species 0.000 description 2
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 2
- 208000031439 Striae Distensae Diseases 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 239000008168 almond oil Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- 229940035437 1,3-propanediol Drugs 0.000 description 1
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 244000144927 Aloe barbadensis Species 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- 241001530056 Athelia rolfsii Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 241000208680 Hamamelis mollis Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- LXNHXLLTXMVWPM-UHFFFAOYSA-N Vitamin B6 Natural products CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 210000000579 abdominal fat Anatomy 0.000 description 1
- 210000003815 abdominal wall Anatomy 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 235000005770 birds nest Nutrition 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000013532 laser treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000008845 photoaging Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 235000005765 wild carrot Nutrition 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of health care products, and particularly relates to an anti-wrinkle composition for postpartum women, and a preparation method and application thereof. The anti-wrinkle health care product for postpartum women comprises the following components: angelica, donkey-hide gelatin and folic acid compounds. The product disclosed by the invention is an oral preparation, can achieve the effects of resisting wrinkles and tightening skin, and can comprehensively improve the problem of wrinkles of the whole skin of a postpartum female.
Description
Technical Field
The invention belongs to the field of health care products, and particularly relates to an anti-wrinkle composition for postpartum women, and a preparation method and application thereof.
Background
After delivery, the women have large weight change before and after production, and the weight changes rapidly in a short time, which may cause skin relaxation and increase of postpartum wrinkles, for example, fine lines, striae gravidarum and the like appear on the face, and the striae gravidarum is serious. The striae gravidarum is mainly formed due to the influence of hormones in pregnancy, and the abdominal distension causes elastic fibers and collagen fibers of the skin to be damaged or broken, so that the abdominal skin becomes thin and thin, and pink or purple wavy patterns with different widths and lengths appear. After delivery, these lines gradually disappear, leaving white or silvery-white shiny scar lines, i.e. stretch marks. Stretch marks appear mainly on the abdominal wall, and may also appear on the inside and outside of the thighs, buttocks, chest, back waist, arms, and the like. The most obvious is the first lying-in woman. Once the striae gravidarum appears, the striae gravidarum cannot disappear, and the striae gravidarum, the breast drop and the abdominal fat accumulation are accompanied, so that the postpartum physical state and the physical and mental health of women are seriously influenced.
The current treatment methods of striae gravidarum include chemical desquamation, skin grinding, laser treatment and treatment with striae gravidarum products. At present, the market has a plurality of products for removing striae gravidarum, but the real effect is too much. The good product for removing the striae gravidarum does not contain alcohol, hormone, pigment and heavy metal components such as lead, mercury and the like, is approved by strict medical skin safety tests, has no allergy and no stimulation, and can be safely and safely used by pregnant and lying-in women and lactating women. The striae gravidarum removing products processed by mineral oil, artificial pigment and various spices in the market can seriously damage the health of pregnant women and babies.
In the prior art, more anti-wrinkle products for pregnant women exist, for example, the Chinese patent application CN 110151624A discloses a striae gravidarum smearing repair essence emulsion, which comprises a striae gravidarum smearing repair essence emulsion, a first component, a second component, a third component, a fourth component and a fifth component; the first component comprises the following components (expressed by mass percent): 35-45 parts of water; 3-8 parts of 1, 3-propanediol; 0.1-0.5 of xanthan gum; sclerotium rolfsii (scleritium mrolfssii) gum 0.05-0.15; 0.05 to 0.15 percent of sodium hyaluronate; 1-3 parts of trehalose; dipotassium glycyrrhizinate 0.1-0.5; 0.5-1.5 parts of nicotinamide; 0.4-1 part of 1, 2-hexanediol; 0.3-0.8 of p-hydroxyacetophenone; allantoin 0.1-0.3; the striae gravidarum smearing repair essence lotion is formed by combining the first component, the second component, the third component, the fourth component and the fifth component, and is smeared on the striae gravidarum of a pregnant woman, so that the aims of resisting wrinkles, removing fine lines and tightening pores in an instant and long-acting manner can be fulfilled. Although the technology has a good anti-wrinkle effect, the components of the technology are various, on one hand, the cost is high, and on the other hand, due to the possible interaction among the components, the situation that whether the pregnant women feel uncomfortable after using the technology is unpredictable. For example, chinese patent application CN 101507695 a discloses a striae gravidarum repair emulsion, which is prepared by blending deionized water, sweet almond oil, witch hazel extract, aloe vera gel, and sunflower seed oil as main materials with an appropriate amount of auxiliary materials including beta-SS, wherein the sweet almond oil is rich in vitamin B1, B2, B6, and VE, which is helpful for anti-itching and inflammation, but its wrinkle-removing effect is not described in detail. Therefore, the development of the anti-wrinkle health food which has simple components and no side effect and is suitable for postpartum women is needed.
Disclosure of Invention
In order to overcome the technical problems, the invention provides an anti-wrinkle composition for postpartum women. The composition can improve skin wrinkle of puerperal female.
In order to achieve the above purpose, the technical scheme provided by the invention is as follows:
an anti-wrinkle composition for postpartum women comprises the following components:
angelica, donkey-hide gelatin and folic acid compounds.
Preferably, the anti-wrinkle composition for postpartum women further comprises tea polyphenol.
Preferably, the anti-wrinkle composition for postpartum women comprises the following components in parts by weight:
30-70 parts of angelica, 10-40 parts of donkey-hide gelatin and 1-2 parts of folic acid compounds.
Preferably, the anti-wrinkle composition for postpartum women comprises the following components in parts by weight:
50 parts of angelica, 25 parts of donkey-hide gelatin and 1.5 parts of folic acid compounds.
Preferably, the anti-wrinkle composition for postpartum women comprises the following components in parts by weight:
30-70 parts of angelica, 10-40 parts of donkey-hide gelatin, 1-2 parts of folic acid compounds and 1-5 parts of tea polyphenol.
Preferably, the anti-wrinkle composition for postpartum women comprises the following components in parts by weight:
50 parts of angelica, 25 parts of donkey-hide gelatin, 1.5 parts of folic acid compounds and 2 parts of tea polyphenol.
Preferably, the folic acid compounds are one or more of folic acid, leucovorin, L-methyl folic acid, pharmaceutically acceptable salts of folic acid, active metabolites of folic acid or pharmaceutically acceptable salts of folic acid, and substances capable of metabolizing and/or generating folic acid in vivo.
The present invention is not particularly limited in terms of the source of the above raw materials, and commercially available products known to those skilled in the art may be used.
The invention also aims to provide a preparation method of the anti-wrinkle composition for postpartum women, which comprises the following steps:
s1, weighing angelica, adding water, heating, decocting and filtering to obtain filtrate 1 and filter residue 1; adding water into the filter residue 1, carrying out second heating decoction, and filtering; preparing filtrate 2 and residue 2, adding water into residue 2, decocting for the third time, and filtering; obtaining filtrate 3 and filter residue 3;
s2, weighing colla Corii Asini, melting with boiling water, and removing oil layer to obtain colla Corii Asini solution;
s3, mixing the filtrate 1, the filtrate 2, the filtrate 3 and the donkey-hide gelatin solution obtained in the step S1, standing, filtering, removing residues, and preparing a mixed solution;
s3, cooling the mixed solution, and concentrating to obtain fluid extract;
s4, drying and sterilizing the clear paste, adding folic acid compounds and tea polyphenol, mixing, drying and sterilizing to obtain the anti-wrinkle composition.
Preferably, in S1, the weight of the water added into the angelica is 8-10 times of the mass of the angelica; the weight of the water added into the filter residue 1 is 4-6 times of the mass of the filter residue 1; the weight of the water added into the filter residue 2 is 2-3 times of the mass of the filter residue 2.
Preferably, the heating and decocting time is 2-4 h; the time for the second heating decoction is 2-3 h; the time for the third heating decoction is 1.5-2.5 h.
Preferably, in S3, the standing time is 24-36 h.
Preferably, in S3, the cooling temperature is 5 to 7 ℃.
Preferably, in S3, the concentration is performed until the relative density of the mixed solution is 1.25 ± 0.05.
Preferably, in S4, the dry sterilization is performed at 80-85 ℃ for 4-6 h.
Preferably, in S4, the mixing is performed in a mixer for 60 to 80 minutes.
Preferably, in S4, the dry sterilization is performed at 80-85 ℃ for 2.5-3 h.
Preferably, the anti-wrinkle composition further comprises additives or excipients acceptable in health care products or medicines and prepared into any dosage form.
Preferably, the dosage form is any one of tablets, oral liquids, granules, capsules, soft extracts, drop pills, powders, lozenges, fluid extracts, injections and syrups.
The invention also aims to provide an anti-wrinkle product for postpartum women, which comprises the anti-wrinkle composition.
Preferably, the anti-wrinkle product is a health product or a medicine.
Compared with the prior art, the invention has the technical advantages that:
(1) the product disclosed by the invention is an oral preparation, can achieve the effects of resisting wrinkles and tightening skin, and can comprehensively improve the problem of wrinkles of the whole skin of a postpartum female.
(2) According to the invention, angelica, donkey-hide gelatin and folic acid compounds are creatively used together, so that striae gravidarum is relieved, fine lines are well faded, folic acid can be supplemented for postpartum women, and the postpartum women can recover physique.
(3) The Chinese angelica and the donkey-hide gelatin which can tonify qi and blood and the folic acid which can promote cell division and growth are used together, so that the Chinese angelica and the donkey-hide gelatin achieve the synergistic effect, thin wrinkles can be quickly faded, qi and blood can be supplemented for postpartum women, and the skin problem of the postpartum women is fundamentally solved.
(4) The invention has the advantages of good naturalness of the selected raw materials, scientific and reasonable formula, wide applicable population, safety, reliability and convenient and fast eating mode.
Detailed Description
The present invention will be described below with reference to specific examples to make the technical aspects of the present invention easier to understand and grasp, but the present invention is not limited thereto. The experimental methods described in the following examples are all conventional methods unless otherwise specified; the reagents and materials are commercially available, unless otherwise specified.
Example 1
The anti-wrinkle composition for postpartum women comprises the following components in parts by weight: 50 parts of angelica, 25 parts of donkey-hide gelatin and 1.5 parts of folic acid.
The preparation method of the anti-wrinkle composition for postpartum women comprises the following steps:
s1, weighing angelica, adding 9 times of water by mass, heating and decocting for 3 hours, and filtering to obtain filtrate 1 and filter residue 1; adding 5 times of water into the filter residue 1, decocting for 2 hr, and filtering; preparing filtrate 2 and residue 2, adding 3 times of water into residue 2, decocting for 2 hr for the third time, and filtering; obtaining filtrate 3 and filter residue 3;
s2, weighing colla Corii Asini, melting with boiling water, and removing oil layer to obtain colla Corii Asini solution;
s3, mixing the filtrate 1, the filtrate 2, the filtrate 3 and the donkey-hide gelatin solution obtained in the step S1, standing for 24 hours, filtering, removing residues, and preparing a mixed solution;
s3, cooling the mixed solution to 6 ℃, and concentrating until the relative density of the mixed solution is 1.25 +/-0.05 to obtain clear paste;
s4, drying and sterilizing the clear paste at 80 ℃ for 5h, adding folic acid, mixing in a mixer for 70 min, and drying and sterilizing at 80 ℃ for 3h to obtain the anti-wrinkle composition.
Example 2
The anti-wrinkle composition for postpartum women comprises the following components in parts by weight: 50 parts of angelica, 25 parts of donkey-hide gelatin, 1.5 parts of folic acid and 2 parts of tea polyphenol.
The preparation method of the anti-wrinkle composition for postpartum women comprises the following steps:
s1, weighing angelica, adding 9 times of water by mass, heating and decocting for 3 hours, and filtering to obtain filtrate 1 and filter residue 1; adding 5 times of water into the filter residue 1, decocting for 2 hr, and filtering; preparing filtrate 2 and residue 2, adding 3 times of water into residue 2, decocting for 2 hr for the third time, and filtering; obtaining filtrate 3 and filter residue 3;
s2, weighing colla Corii Asini, melting with boiling water, and removing oil layer to obtain colla Corii Asini solution;
s3, mixing the filtrate 1, the filtrate 2, the filtrate 3 and the donkey-hide gelatin solution obtained in the step S1, standing for 24 hours, filtering, removing residues, and preparing a mixed solution;
s3, cooling the mixed solution to 6 ℃, and concentrating until the relative density of the mixed solution is 1.25 +/-0.05 to obtain clear paste;
s4, drying and sterilizing the clear paste at 80 ℃ for 5h, adding folic acid and tea polyphenol, mixing in a mixer for 70 min, and drying and sterilizing at 80 ℃ for 3h to obtain the anti-wrinkle composition.
Example 3
The anti-wrinkle composition for postpartum women comprises the following components in parts by weight: 30 parts of angelica, 40 parts of donkey-hide gelatin, 1 part of formyl tetrahydrofolic acid and 5 parts of tea polyphenol.
The preparation method of the anti-wrinkle composition for postpartum women comprises the following steps:
s1, weighing angelica, adding 8 times of water by mass, heating and decocting for 2 hours, and filtering to obtain filtrate 1 and filter residue 1; adding 4 times of water into the residue 1, decocting for 2 hr, and filtering; preparing filtrate 2 and residue 2, adding 3 times of water into residue 2, decocting for the third time for 1.5 hr, and filtering; obtaining filtrate 3 and filter residue 3;
s2, weighing colla Corii Asini, melting with boiling water, and removing oil layer to obtain colla Corii Asini solution;
s3, mixing the filtrate 1, the filtrate 2, the filtrate 3 and the donkey-hide gelatin solution obtained in the step S1, standing for 24 hours, filtering, removing residues, and preparing a mixed solution;
s3, cooling the mixed solution to 5 ℃, and concentrating until the relative density of the mixed solution is 1.25 +/-0.05 to obtain clear paste;
s4, drying and sterilizing the clear paste at 85 ℃ for 4h, adding formyltetrahydrofolic acid and tea polyphenol, mixing in a mixer for 60 min, and drying and sterilizing at 85 ℃ for 2.5h to obtain the anti-wrinkle composition.
Example 4
The anti-wrinkle composition for postpartum women comprises the following components in parts by weight: 70 parts of angelica, 10 parts of donkey-hide gelatin, 2 parts of L-methyl folic acid and 1 part of tea polyphenol.
The preparation method of the anti-wrinkle composition for postpartum women comprises the following steps:
s1, weighing angelica, adding water with the mass being 10 times that of the angelica, heating and decocting for 4 hours, and filtering to obtain filtrate 1 and filter residue 1; adding 6 times of water into the filter residue 1, decocting for 3 hr, and filtering; preparing filtrate 2 and residue 2, adding 2 times of water to residue 2, decocting for 2.5 hr for the third time, and filtering; obtaining filtrate 3 and filter residue 3;
s2, weighing colla Corii Asini, melting with boiling water, and removing oil layer to obtain colla Corii Asini solution;
s3, mixing the filtrate 1, the filtrate 2, the filtrate 3 and the donkey-hide gelatin solution obtained in the step S1, standing for 36 hours, filtering, removing residues, and preparing a mixed solution;
s3, cooling the mixed solution to 7 ℃, and concentrating until the relative density of the mixed solution is 1.25 +/-0.05 to obtain clear paste;
s4, drying and sterilizing the clear paste at 80 ℃ for 6h, adding L-methyl folic acid and tea polyphenol, mixing in a mixer for 80 min, and drying and sterilizing at 80 ℃ for 3h to obtain the anti-wrinkle composition.
Comparative example 1
Compared with example 2, the difference is in the composition difference: replacing colla Corii Asini with nidus Collocaliae.
The anti-wrinkle composition for postpartum women comprises the following components in parts by weight: 50 parts of angelica, 25 parts of bird's nest, 1.5 parts of folic acid and 2 parts of tea polyphenol.
The preparation method of the anti-wrinkle composition for postpartum women comprises the following steps:
s1, weighing angelica, adding 9 times of water by mass, heating and decocting for 3 hours, and filtering to obtain filtrate 1 and filter residue 1; adding 5 times of water into the filter residue 1, decocting for 2 hr, and filtering; preparing filtrate 2 and residue 2, adding 3 times of water into residue 2, decocting for 2 hr for the third time, and filtering; obtaining filtrate 3 and filter residue 3;
s2, weighing cubilose, and stewing until the cubilose is hydrated to obtain cubilose solution;
s3, combining the filtrate 1, the filtrate 2, the filtrate 3 and the cubilose solution obtained in the step S1, standing for 24 hours, filtering, removing residues, and preparing a mixed solution;
s3, cooling the mixed solution to 6 ℃, and concentrating until the relative density of the mixed solution is 1.25 +/-0.05 to obtain clear paste;
s4, drying and sterilizing the clear paste at 80 ℃ for 5h, adding folic acid and tea polyphenol, mixing in a mixer for 70 min, and drying and sterilizing at 80 ℃ for 3h to obtain the anti-wrinkle composition.
Comparative example 2
Compared with example 2, the difference is in the composition difference: radix Angelicae sinensis is replaced by Saviae Miltiorrhizae radix.
The anti-wrinkle composition for postpartum women comprises the following components in parts by weight: 50 parts of salvia miltiorrhiza, 25 parts of donkey-hide gelatin, 1.5 parts of folic acid and 2 parts of tea polyphenol.
The preparation method of the anti-wrinkle composition for postpartum women comprises the following steps:
s1, weighing the salvia miltiorrhiza, adding 9 times of water by mass, heating and decocting for 3 hours, and filtering to obtain filtrate 1 and filter residue 1; adding 5 times of water into the filter residue 1, decocting for 2 hr, and filtering; preparing filtrate 2 and residue 2, adding 3 times of water into residue 2, decocting for 2 hr for the third time, and filtering; obtaining filtrate 3 and filter residue 3;
s2, weighing colla Corii Asini, melting with boiling water, and removing oil layer to obtain colla Corii Asini solution;
s3, mixing the filtrate 1, the filtrate 2, the filtrate 3 and the donkey-hide gelatin solution obtained in the step S1, standing for 24 hours, filtering, removing residues, and preparing a mixed solution;
s3, cooling the mixed solution to 6 ℃, and concentrating until the relative density of the mixed solution is 1.25 +/-0.05 to obtain clear paste;
s4, drying and sterilizing the clear paste at 80 ℃ for 5h, adding folic acid and tea polyphenol, mixing in a mixer for 70 min, and drying and sterilizing at 80 ℃ for 3h to obtain the anti-wrinkle composition.
Comparative example 3
Compared with example 2, the difference lies in the preparation method.
The anti-wrinkle composition for postpartum women comprises the following components in parts by weight: 50 parts of angelica, 25 parts of donkey-hide gelatin, 1.5 parts of folic acid and 2 parts of tea polyphenol.
The preparation method of the anti-wrinkle composition for postpartum women comprises the following steps:
s1, weighing angelica, adding 9 times of water by mass, heating and decocting for 7 hours, and filtering to obtain filtrate;
s2, weighing colla Corii Asini, melting with boiling water, and removing oil layer to obtain colla Corii Asini solution;
s3, mixing the filtrate in the S1 with the donkey-hide gelatin solution, standing for 24 hours, filtering, removing residues, and preparing a mixed solution;
s3, cooling the mixed solution to 6 ℃, and concentrating until the relative density of the mixed solution is 1.25 +/-0.05 to obtain clear paste;
s4, drying and sterilizing the clear paste at 80 ℃ for 5h, adding folic acid and tea polyphenol, mixing in a mixer for 70 min, and drying and sterilizing at 80 ℃ for 3h to obtain the anti-wrinkle composition.
Examples of effects
The compositions prepared in examples 1 to 3 and comparative examples 1 to 3 were prepared into granules (the content of the composition in the granules is not limited, and the products fed during the elasticity test and the anti-wrinkle test were used in amounts calculated based on the actual weight of the composition in the products as an effective content).
1. Elasticity test
Female volunteers 35 aged 25-35 years and within 1 year of postpartum and weighing within 50-70kg were selected and randomly divided into 7 groups of 5 persons each, namely, a control group, examples 1-3 groups and comparative examples 1-3 groups. Wherein, the groups of examples 1-3 and comparative examples 1-3 were tasted daily for anti-wrinkle products of the corresponding group at an effective content of 0.25 g/kg; during the period of taking the anti-wrinkle product, the diet was balanced normally, and the control group had only balanced normal diet. After 12 weeks of continuous taking, the skin elasticity of the lower abdomen before and after taking the anti-wrinkle product was measured using the skin elasticity tester MPA580 of CK company, Germany, and the R2 value was recorded (R2 value is the ratio of the amount of springback of the skin without negative pressure to the maximum amount of stretch in the presence of negative pressure, and the ratio is approximately 1, indicating that the skin elasticity is better). The results are shown in Table 1.
TABLE 1 skin elasticity
| Test group | Initial skin elasticity R2 value | Skin elasticity R2 value after 12 weeks |
| Control group | 0.54±0.12 | 0.59±0.11 |
| Example 1 | 0.46±0.07 | 0.65±0.14 |
| Example 2 | 0.51±0.16 | 0.77±0.06* |
| Example 3 | 0.53±0.09 | 0.76±0.13* |
| Comparative example 1 | 0.48±0.21 | 0.69±0.16 |
| Comparative example 2 | 0.55±0.17 | 0.67±0.19 |
| Comparative example 3 | 0.49±0.08 | 0.70±0.07 |
Note: p < 0.05 compared to control.
2. Anti-wrinkle effect
70 six-week-old hairless mice were selected and divided into 7 groups of 10 mice each, according to examples 1 to 3 and comparative examples 1 to 3, and a control group. The groups of examples 1 to 3 and comparative examples 1 to 3 were fed the corresponding products daily at an effective content of 0.25g/kg, and the normal diet and drinking water during the period of taking the anti-wrinkle product, and the normal diet and drinking water of the control group. During the experiment, the dorsal part of hairless mice was irradiated with UVB ultraviolet rays at a frequency of 30min once a day to induce photoaging, and the dose of UVB irradiation was set to 100mJ/cm2. The irradiation is continued for 10 weeks, and the wrinkle of the dorsal part of the mouse is observed on the 1 st day after the completion of the experiment to evaluate the wrinkle-resistant effect. Evaluation criteria: scoring for 0-5 points according to the depth, length and length of wrinkles, and scoring for 0 point when no wrinkles are observed, and scoring for deep and long dorsal partThe number of wrinkles was 5, and the scoring was performed by three testers, and the average of the three was taken as the final result (the average has a decimal part and is rounded up to an integer). The results are shown in Table 2.
TABLE 2 anti-wrinkle effects experiment
| Test group | Scoring |
| Control group | 37 |
| Example 1 | 23 |
| Example 2 | 12 |
| Example 3 | 11 |
| Comparative example 1 | 26 |
| Comparative example 2 | 29 |
| Comparative example 3 | 18 |
Therefore, the anti-wrinkle health care product provided by the invention has a good anti-wrinkle effect. And the composition and the preparation method of the anti-wrinkle product have great influence on the anti-wrinkle effect.
The above detailed description is specific to one possible embodiment of the present invention, and the embodiment is not intended to limit the scope of the present invention, and all equivalent implementations or modifications without departing from the scope of the present invention should be included in the technical scope of the present invention.
Claims (10)
1. An anti-wrinkle composition for postpartum women comprises the following components: angelica, donkey-hide gelatin and folic acid compounds.
2. The anti-wrinkle composition for postpartum women according to claim 1, wherein the anti-wrinkle composition for postpartum women comprises the following components in parts by weight: 30-70 parts of angelica, 10-40 parts of donkey-hide gelatin and 1-2 parts of folic acid compounds.
3. The anti-wrinkle composition for postpartum women according to claim 1, wherein the anti-wrinkle composition for postpartum women further comprises tea polyphenols.
4. The anti-wrinkle composition for postpartum women according to claim 3, wherein the anti-wrinkle composition for postpartum women comprises the following components in parts by weight: 30-70 parts of angelica, 10-40 parts of donkey-hide gelatin, 1-2 parts of folic acid compounds and 1-5 parts of tea polyphenol.
5. The anti-wrinkle composition for postpartum women according to claim 1, wherein the folic acid compounds are one or more of folic acid, leucovorin, L-methyl folic acid, pharmaceutically acceptable salts of folic acid, active metabolites of folic acid or pharmaceutically acceptable salts of folic acid, and substances capable of metabolizing and/or generating folic acid in vivo.
6. The method for preparing the anti-wrinkle composition for postpartum women according to any one of claims 1 to 5, comprising the steps of:
s1, weighing angelica, adding water, heating, decocting and filtering to obtain filtrate 1 and filter residue 1; adding water into the filter residue 1, carrying out second heating decoction, and filtering; preparing filtrate 2 and residue 2, adding water into residue 2, decocting for the third time, and filtering; obtaining filtrate 3 and filter residue 3;
s2, weighing colla Corii Asini, melting with boiling water, and removing oil layer to obtain colla Corii Asini solution;
s3, mixing the filtrate 1, the filtrate 2, the filtrate 3 and the donkey-hide gelatin solution obtained in the step S1, standing, filtering, removing residues, and preparing a mixed solution;
s3, cooling the mixed solution, and concentrating to obtain fluid extract;
s4, drying and sterilizing the clear paste, adding folic acid compounds and tea polyphenol, mixing, drying and sterilizing to obtain the anti-wrinkle composition.
7. The method for preparing the anti-wrinkle composition for postpartum women as in claim 6, wherein in S1, the weight of the water added into the angelica sinensis is 8-10 times of the weight of the angelica sinensis; the weight of the water added into the filter residue 1 is 4-6 times of the mass of the filter residue 1; the weight of the water added into the filter residue 2 is 2-3 times of the mass of the filter residue 2; the heating and decocting time is 2-4 h; the time for the second heating decoction is 2-3 h; the time for the third heating decoction is 1.5-2.5 h.
8. The method for preparing the anti-wrinkle composition for postpartum women as in claim 6, wherein the standing time in S3 is 24-36 h; the cooling temperature is 5-7 ℃; in S3, the concentration is performed until the relative density of the mixed solution is 1.25 ± 0.05.
9. The method for preparing the anti-wrinkle composition for postpartum women as in claim 6, wherein the drying and sterilizing are performed at 80-85 ℃ for 4-6h in S4; the mixing is carried out in a mixer for 60-80 minutes; the drying and disinfection are carried out for 2.5-3h at the temperature of 80-85 ℃.
10. An anti-wrinkle product for postpartum women, comprising the anti-wrinkle composition for postpartum women according to any one of claims 1 to 5 or the anti-wrinkle composition for postpartum women prepared by the method for preparing the anti-wrinkle composition for postpartum women according to any one of claims 6 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110155256.XA CN112914099B (en) | 2021-02-04 | 2021-02-04 | Anti-wrinkle composition for female postpartum use and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110155256.XA CN112914099B (en) | 2021-02-04 | 2021-02-04 | Anti-wrinkle composition for female postpartum use and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112914099A true CN112914099A (en) | 2021-06-08 |
| CN112914099B CN112914099B (en) | 2023-07-14 |
Family
ID=76170379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110155256.XA Active CN112914099B (en) | 2021-02-04 | 2021-02-04 | Anti-wrinkle composition for female postpartum use and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112914099B (en) |
Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0028706D0 (en) * | 2000-11-24 | 2001-01-10 | Unilever Plc | Cosmetic composition |
| CN102283342A (en) * | 2011-06-29 | 2011-12-21 | 中国航天员科研训练中心 | Functional total-nutrient liquid food for space flight and preparation method thereof |
| CN102631480A (en) * | 2012-04-20 | 2012-08-15 | 苏州爱斯欧蒂生物科技有限公司 | Toxin-expelling beautifying health-care product |
| US20130004598A1 (en) * | 2011-07-01 | 2013-01-03 | Shorong-Shii Liou | Herbal Preparation for Anemia and a Manufacture Method Thereof |
| CN103223128A (en) * | 2012-01-30 | 2013-07-31 | 王凡 | Traditional Chinese medicine composition for improving alimentary anemia and preparation method |
| CN104351382A (en) * | 2014-01-17 | 2015-02-18 | 车传东 | Anti-radiation blood-enriching health tea cream and preparation method thereof |
| CN105362457A (en) * | 2015-12-07 | 2016-03-02 | 陕西百年健康药业有限公司 | Formula of Yingmei granules and process for preparing same |
| CN105942495A (en) * | 2016-04-29 | 2016-09-21 | 山东邓记阿胶有限公司 | Feature beautifying donkey-hide gelatin cakes and preparation method thereof |
| CN107096007A (en) * | 2017-04-13 | 2017-08-29 | 中唐慈幼（北京）生物科技有限公司 | A kind of postpartum recuperating composition and preparation method thereof |
| CN108553535A (en) * | 2018-04-18 | 2018-09-21 | 襄城县实验学校 | A kind of pregnant woman's postpartum, which enriches blood, uses oral solution |
| CN108904697A (en) * | 2018-08-30 | 2018-11-30 | 吉林省恒实传食品科技发展有限公司 | A kind of female irregular menstruation conditioning cream and preparation method thereof |
| CN109350705A (en) * | 2018-12-24 | 2019-02-19 | 建昌帮药业有限公司 | A kind of composition and application with blood-enriching face-nourishing and strengthen immunity effect |
| CN109718303A (en) * | 2019-03-20 | 2019-05-07 | 江西天元药业有限公司 | Improving the skin maintenance and cosmetic benefits of female ovary function improves the Chinese medicine composition of female skin |
| CN110742269A (en) * | 2019-12-10 | 2020-02-04 | 北京斯利安药业有限公司 | Memory enhancing composition suitable for postpartum women and preparation method thereof |
| CN111528483A (en) * | 2020-05-21 | 2020-08-14 | 青岛自然珍萃生物科技有限公司 | Functional meal replacement powder with balanced nutrition and preparation method thereof |
| CN112869159A (en) * | 2021-02-04 | 2021-06-01 | 建昌帮药业有限公司 | Anti-wrinkle health product containing folic acid |
-
2021
- 2021-02-04 CN CN202110155256.XA patent/CN112914099B/en active Active
Patent Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0028706D0 (en) * | 2000-11-24 | 2001-01-10 | Unilever Plc | Cosmetic composition |
| CN102283342A (en) * | 2011-06-29 | 2011-12-21 | 中国航天员科研训练中心 | Functional total-nutrient liquid food for space flight and preparation method thereof |
| US20130004598A1 (en) * | 2011-07-01 | 2013-01-03 | Shorong-Shii Liou | Herbal Preparation for Anemia and a Manufacture Method Thereof |
| CN103223128A (en) * | 2012-01-30 | 2013-07-31 | 王凡 | Traditional Chinese medicine composition for improving alimentary anemia and preparation method |
| CN102631480A (en) * | 2012-04-20 | 2012-08-15 | 苏州爱斯欧蒂生物科技有限公司 | Toxin-expelling beautifying health-care product |
| CN104351382A (en) * | 2014-01-17 | 2015-02-18 | 车传东 | Anti-radiation blood-enriching health tea cream and preparation method thereof |
| CN105362457A (en) * | 2015-12-07 | 2016-03-02 | 陕西百年健康药业有限公司 | Formula of Yingmei granules and process for preparing same |
| CN105942495A (en) * | 2016-04-29 | 2016-09-21 | 山东邓记阿胶有限公司 | Feature beautifying donkey-hide gelatin cakes and preparation method thereof |
| CN107096007A (en) * | 2017-04-13 | 2017-08-29 | 中唐慈幼（北京）生物科技有限公司 | A kind of postpartum recuperating composition and preparation method thereof |
| CN108553535A (en) * | 2018-04-18 | 2018-09-21 | 襄城县实验学校 | A kind of pregnant woman's postpartum, which enriches blood, uses oral solution |
| CN108904697A (en) * | 2018-08-30 | 2018-11-30 | 吉林省恒实传食品科技发展有限公司 | A kind of female irregular menstruation conditioning cream and preparation method thereof |
| CN109350705A (en) * | 2018-12-24 | 2019-02-19 | 建昌帮药业有限公司 | A kind of composition and application with blood-enriching face-nourishing and strengthen immunity effect |
| CN109718303A (en) * | 2019-03-20 | 2019-05-07 | 江西天元药业有限公司 | Improving the skin maintenance and cosmetic benefits of female ovary function improves the Chinese medicine composition of female skin |
| CN110742269A (en) * | 2019-12-10 | 2020-02-04 | 北京斯利安药业有限公司 | Memory enhancing composition suitable for postpartum women and preparation method thereof |
| CN111528483A (en) * | 2020-05-21 | 2020-08-14 | 青岛自然珍萃生物科技有限公司 | Functional meal replacement powder with balanced nutrition and preparation method thereof |
| CN112869159A (en) * | 2021-02-04 | 2021-06-01 | 建昌帮药业有限公司 | Anti-wrinkle health product containing folic acid |
Non-Patent Citations (5)
| Title |
|---|
| 于守洋: "关于中国营养保健食品的若干讨论意见之二：中国营养保健食品的理论基础与有效成分原料资源", 《中国公共卫生》 * |
| 于守洋: "关于中国营养保健食品的若干讨论意见之二：中国营养保健食品的理论基础与有效成分原料资源", 《中国公共卫生》, vol. 12, no. 02, 10 February 1996 (1996-02-10), pages 70 - 72 * |
| 曾满红等: "茶多酚延缓皮肤光老化的药效学实验研究", 《宜春学院学报》 * |
| 曾满红等: "茶多酚延缓皮肤光老化的药效学实验研究", 《宜春学院学报》, vol. 33, no. 12, 25 December 2011 (2011-12-25), pages 91 - 92 * |
| 韩彦彬;彭亮;赵鹏;李彬;张洁宏;覃辉艳;姚思宇;李凤文;黄超培;: "云亭牌阿胶口服液改善大鼠营养性贫血的效果评价", 中国卫生检验杂志, no. 08, pages 1765 - 1767 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112914099B (en) | 2023-07-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20020098253A1 (en) | Oral compositions containing lotus | |
| CN103705421A (en) | Moisturizing and anti-aging milk cream and preparation method thereof | |
| CN111529477A (en) | Composition for caring hair, and preparation and application thereof | |
| CN106491454A (en) | Chinese medicinal toothpaste | |
| CN103989618B (en) | For toothpaste treating gingivitis and preparation method thereof | |
| CN102389539B (en) | Pure traditional Chinese medicine preparation for removing speckle and beautifying, and preparation method of pulvis and particle of the preparation | |
| CN111494496A (en) | Traditional Chinese medicine composition for growing and blackening hair and preparation method and application thereof | |
| KR102204346B1 (en) | Composition for relieving menopausal symptom or osteoporosis | |
| KR101817514B1 (en) | New use of hesperetin | |
| CN109260119A (en) | A kind of anti-acne repairs facial mask and preparation method thereof | |
| CN112914099A (en) | Anti-wrinkle composition for postpartum women and preparation method and application thereof | |
| CN112826892B (en) | Traditional Chinese medicine for treating alopecia areata, androgenetic alopecia and white hair and preparation method of medicine thereof | |
| CN106963845A (en) | It is a kind of to be used to protect female to prolong the Chinese medicine composition in spring and preparation method thereof | |
| CN107362244A (en) | A kind of Eradicates removes the Chinese medical extract and its external preparation of red blood trace on face | |
| CN110201122B (en) | Traditional Chinese medicine composition for treating irregular menstruation and preparation method and application thereof | |
| KR102100333B1 (en) | Composition for preventing hair loss and promoting hair growth containing mixed extract of Salvia plebia, Polygala tenuifolia and Aloe Barbadensis | |
| CN113101245A (en) | Composition and care product with effect of repairing stretch marks | |
| KR20110023531A (en) | Cosmetic composition for improving bust drooping and elasticity | |
| CN104435368A (en) | Radiation-proof Chinese medicinal preparation as well as preparation method and application thereof | |
| CN109331129A (en) | A kind of Chinese medicine dietary product and preparation method thereof suitable for the proliferation of mammary gland | |
| CN101897828A (en) | Pharmaceutical composition with chloasma-dispelling function and preparation method thereof | |
| KR20180134730A (en) | Patch for prevention and treatment of stretch mark | |
| CN102949567A (en) | Medicinal capsule for removing chloasma and preparation method thereof | |
| CN109468182B (en) | Whitening and beautifying soap and preparation method thereof | |
| CN114601779A (en) | Facial mask with functions of tendering skin and improving metabolism and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |