CN112826866B

CN112826866B - Modified sanguisorba officinalis gargle for treating oral mucositis and preparation method thereof

Info

Publication number: CN112826866B
Application number: CN202110095025.4A
Authority: CN
Inventors: 尤海玲
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-01-25
Filing date: 2021-01-25
Publication date: 2022-04-19
Anticipated expiration: 2041-01-25
Also published as: CN112826866A

Abstract

The invention relates to the fields of medicine, health care and disinfection, in particular to an added sanguisorba gargle for treating oral mucositis and a preparation method thereof. The formula is prepared according to the theory of ancient method, the thought is strict, the medicinal properties and the flavors are properly combined, no toxic medicine is generated, the formula is used for gargling, and patients can feed back sweet flavor which is easily accepted. Clinical observation shows that the healing time of the ulcer surface of the oral mucositis is fast, the ulcer surface can be healed generally within 3-5 days, the effect can still be achieved after the oral mucositis is repeatedly used, the medicine can not be resisted, the life quality of a patient is improved, the use frequency of albumin, antibiotics and the like during treatment is reduced, the hospitalization cost is reduced, and the oral mucositis has certain economic and social values and is worthy of popularization clinically. Meanwhile, the modified sanguisorba officinalis gargle disclosed by the invention has the characteristics of reasonable formula, easiness in obtaining components, simple production process, good reproducibility, remarkable curative effect, small toxic and side effects and no pungent smell. Can be used for treating recurrent oral ulcer, and can remarkably eliminate symptoms such as oral ulcer, exudation, congestion, hemorrhage, edema and pain caused by the disease.

Description

Modified sanguisorba officinalis gargle for treating oral mucositis and preparation method thereof

Technical Field

The invention relates to the fields of medicine, health care and disinfection, in particular to an added sanguisorba gargle for treating oral mucositis and a preparation method thereof.

Background

Oral mucosal tissues and cells are metabolized quickly, so that oral mucositis often occurs after radiotherapy and chemotherapy of malignant tumors and in patients with oral targeted drugs. Head and neck tumors are clinically treated by multiple choices of radiotherapy due to physiological and anatomical reasons, and are considered to be pathogenic heat-toxicity according to the reaction after radiotherapy. On the one hand, the heat toxin can consume qi, blood and body fluid of the whole body, especially qi and yin; the pathogenic heat-toxin locally enters nutrient-blood to cause the occurrence of radioactive oral mucositis. The traditional Chinese medicine composition has a certain treatment scheme for modern medicine of oral mucositis caused by chemotherapy, but the clinical application is not wide, and on one hand, the acquisition of the guideline medicine is difficult in clinical practice; on the other hand, the economic benefit is poor. Therefore, in clinic, many doctors seek from the perspective of traditional Chinese medicine, and have certain effects whether taking orally or gargling. The gargling traditional Chinese medicine compound prescription and the single prescription are not few, wherein part of the gargling traditional Chinese medicine compound prescription contains toxic substances, and the other part of the gargling traditional Chinese medicine compound prescription contains medicines with pungent odor, so that the gargling traditional Chinese medicine compound prescription is not easy to accept by patients.

Disclosure of Invention

In order to solve the problems, the invention provides a flavored sanguisorba officinalis gargle for treating oral mucositis and a preparation method thereof, so that the defect that a patient is not easy to accept the gargle with side effects because part of the gargle contains toxic products and part of the gargle contains drugs with pungent odor in the prior art is overcome. The gargle has good curative effect and low cost, so that the process of treating oral mucositis by using the traditional Chinese medicine is milder.

In order to achieve the purpose, the invention adopts the technical scheme that: a flavored garden burnet gargle for treating oral mucositis is prepared from the following raw materials in parts by mass: 10-30 parts of garden burnet, 10-30 parts of purslane, 15-25 parts of dark plum fruit, 5-10 parts of coptis chinensis, 5-15 parts of scutellaria baicalensis, 10-20 parts of madder root, 10-30 parts of weeping forsythia, 10-30 parts of honeysuckle flower, 15-30 parts of raw liquorice, 20-50 parts of gypsum, 10-20 parts of lucid ganoderma, 15-30 parts of dandelion, 15-30 parts of radix zanthoxyli, 1200 parts of water and 1200 parts of preservative.

The application also provides a preparation method of the flavored sanguisorba officinalis gargle for treating oral mucositis, which comprises the following steps:

step 1: weighing 10-30 parts of garden burnet, 10-30 parts of purslane, 15-25 parts of dark plum fruit, 5-10 parts of coptis chinensis, 5-15 parts of scutellaria baicalensis, 10-20 parts of madder root, 10-30 parts of fructus forsythiae, 10-30 parts of honeysuckle flower, 15-30 parts of raw liquorice, 20-50 parts of gypsum, 10-20 parts of lucid ganoderma, 15-30 parts of dandelion and 15-30 parts of radix zanthoxyli according to the parts by weight, and uniformly mixing;

step 2: weighing 500-700 parts of water according to the weight part ratio, adding the water into the mixed raw materials in the step 1, heating, decocting with strong fire until the materials are boiled, continuing to decoct with slow fire for 20-45 min, stopping heating, and filtering to obtain a first filtrate for later use;

and step 3: weighing 500 portions of 300-500 portions of water according to the weight portion ratio, adding the water into the filter residue after the primary filtrate is extracted, decocting with strong fire until the filter residue is boiled and then is further decocted with slow fire for 20-45 min, stopping heating, and filtering to obtain a secondary filtrate;

and 4, step 4: mixing the first filtrate and the second filtrate, decocting, and concentrating to obtain collutory with concentration of 1.2g/mL-1.6 g/mL.

And 5: and (4) adding 2-4 parts of preservative into the gargle prepared in the step (4) and uniformly stirring, wherein the preservative is sodium benzoate.

Further, the water used in step 2 and step 3 is purified water.

Further, the specific steps of step 2 are: weighing 700 parts of purified water by weight, adding the purified water into the mixed raw materials obtained in the step 1, soaking for 15-45 min, heating, decocting with strong fire until boiling, continuing to decoct with slow fire for 20-45 min, stopping heating, filtering, and taking the primary filtrate for later use.

Further, the application provides a specific preferred example, a preparation method of the flavored sanguisorba officinalis gargle for treating oral mucositis comprises the following specific steps:

step 1: weighing 30 parts of garden burnet, 30 parts of purslane, 15 parts of dark plum fruit, 5 parts of coptis chinensis, 10 parts of scutellaria baicalensis, 15 parts of madder root, 15 parts of weeping forsythia, 15 parts of honeysuckle, 25 parts of raw liquorice, 30 parts of gypsum, 20 parts of lucid ganoderma, 30 parts of dandelion and 30 parts of radix zanthoxyli according to the weight parts, and uniformly mixing;

step 2: weighing 600 parts of water according to the weight part ratio, adding the water into the mixed raw materials in the step 1, heating, decocting with strong fire until the mixture is boiled, continuing to decoct with slow fire for 30min, stopping heating, and filtering to obtain a first filtrate for later use;

and step 3: weighing 400 parts of water according to the weight part ratio, adding the water into the filter residue after the first filtrate is extracted, decocting with strong fire until the water is boiling, continuing to decoct with slow fire for 30min, stopping heating, and filtering to obtain a second filtrate;

and 4, step 4: mixing the first filtrate and the second filtrate, decocting, and concentrating to obtain collutory with concentration of 1.4 g/mL;

and 5: adding preservative into the gargle prepared in the step 4 and stirring uniformly, wherein the usage amount of the preservative is 0.3 percent, namely, 0.3g of the preservative is directly added into every 100mL of the gargle.

The invention has the beneficial effects that:

1. the formula is prepared according to the theory of an ancient method, the thought is strict, the medicinal properties and the taste are properly compatible, no toxic medicine exists, and the patient can feel sweet after gargling by using the formula, so that the formula is easily accepted. Clinical observation shows that the healing time of the ulcer surface of the oral mucositis is fast, the ulcer surface can be healed generally within 3-5 days, the effect can still be achieved after the oral mucositis is repeatedly used, the medicine can not be resisted, the life quality of a patient is improved, the use frequency of albumin, antibiotics and the like during treatment is reduced, the hospitalization cost is reduced, and the oral mucositis has certain economic and social values and is worthy of popularization clinically.

2. The recurrent aphtha is frequently found in middle-aged and young patients, clinical observation is mostly related to fire evil due to yin deficiency, and according to the theory of simultaneous treatment of the traditional Chinese medicine, the method of gargling with oral administration by the formula can accelerate ulcer healing and prevent recurrence, thereby killing two birds with one stone. Therefore, the method is worthy of clinical popularization. Certainly, a large sample is needed to observe the curative effect of the oral mucositis and the recurrent aphthous ulcer after the chemotherapy and radiotherapy of the prescription and the oral administration of the targeted medicament, the action mechanism of the local microenvironment of the oral cavity of the mouth wash of the prescription is further observed through experiments, the mechanism of the oral mucositis and the recurrent aphthous ulcer after the chemotherapy and radiotherapy of the prescription is discussed, and a solid foundation is laid for clinical popularization and application.

3. The modified sanguisorba officinalis gargle disclosed by the invention has the characteristics of reasonable formula, easiness in obtaining components, simple production process, good reproducibility, remarkable curative effect, small toxic and side effects and no pungent smell. Can be used for treating recurrent oral ulcer, and can remarkably eliminate symptoms such as oral ulcer, exudation, congestion, hemorrhage, edema and pain caused by the disease, and has advantages of low recurrence rate, sweet taste, good taste, and suitability for all ages. And the modified sanguisorba gargle is applied, so that the patient can take the gargle orally and gargle at the same time, and the internal and external combined treatment can accelerate the ulcer healing, reduce the recurrence and greatly improve the life quality of the patient.

Detailed Description

The invention provides a flavored sanguisorba officinalis gargle for treating oral mucositis, which comprises the following raw materials in parts by mass: 10-30 parts of garden burnet, 10-30 parts of purslane, 15-25 parts of dark plum fruit, 5-10 parts of coptis chinensis, 5-15 parts of scutellaria baicalensis, 10-20 parts of madder root, 10-30 parts of weeping forsythia, 10-30 parts of honeysuckle flower, 15-30 parts of raw liquorice, 20-50 parts of gypsum, 10-20 parts of lucid ganoderma, 15-30 parts of dandelion, 15-30 parts of radix zanthoxyli and 1200 parts of water.

Sanguisorba officinalis is cold in nature, slightly bitter in taste and nontoxic, belongs to liver, lung, kidney and large intestine channels, and has the effects of cooling blood, stopping bleeding, clearing heat and detoxicating, nourishing yin, relieving swelling and healing sore.

Purslane, being sour in taste and cold in nature, enters liver and large intestine channels and has the effects of clearing heat and removing toxicity, cooling blood and stopping bleeding and stopping dysentery.

Dark plum is astringent in nature, sour, astringent and neutral in flavor, and enters liver, spleen, lung and large intestine meridians.

Coptis chinensis, for clearing heat and drying dampness, purging fire and removing toxicity, is used for treating damp-heat fullness, vomiting and acid regurgitation, dysentery, jaundice, high fever and coma, hyperactivity of heart fire, vexation and insomnia, blood heat and hematemesis and epistaxis, conjunctival congestion, toothache, diabetes, carbuncle and furuncle; it is used externally to treat eczema, eczema and purulent ear canal.

Scutellaria baicalensis, bitter and cold in property, can clear away the lung-heat, and damp-heat in stomach, liver and gallbladder and large intestine, and can be used for treating damp-warm disease or early summer-heat damp disease manifested by fever without Yang, stuffiness in chest and epigastrium, yellow and greasy tongue coating, etc.; huang Qin has the actions of clearing heat, purging fire and removing toxicity, and is often combined with Huang Lian, Huang Bai and Zhi Zi to treat abscess, swelling and sore.

Radix Rubiae, radix Rubiae is bitter and cold in flavor, and has the main effects of cooling blood and stopping bleeding, and activating blood and dredging meridians.

Lian Qiao can clear heat and remove toxicity, resolve swelling and dissipate nodulation. Can be used for treating carbuncle, cellulitis, scrofula, acute mastitis, erysipelas, wind-heat type common cold, early epidemic febrile disease, warm heat entering nutrient system, hyperpyrexia, polydipsia, coma, macula, and stranguria with heat.

Honeysuckle flower, sweet in nature and cold in nature, enters lung, heart and stomach meridians, clears away heat and toxic materials, and disperses wind and heat, and is the monarch drug.

Raw licorice root, radix Glycyrrhizae Praeparata, has the effects of invigorating the spleen and replenishing qi, clearing away heat and toxic materials, expelling phlegm and arresting cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.

Gypsum, Gypsum Fibrosum Preparatum, has effects of clearing heat and purging fire, relieving restlessness, quenching thirst, astringing and promoting granulation (Gypsum Fibrosum Preparatum).

The ganoderma lucidum can also promote the metabolism of the liver to drugs and poisons, and has definite curative effect on toxic hepatitis.

Dandelion, herba Taraxaci, clears away heat and toxic material, induces diuresis and dissipates nodulation.

Radix Zanthoxyli has effects of promoting blood circulation, removing blood stasis, relieving pain, and eliminating swelling.

Further, the flavored sanguisorba gargle also comprises the following raw materials in parts by weight: 2-4 parts of a preservative.

Further, still include: and 5, adding a preservative into the gargle prepared in the step 4 and uniformly stirring, wherein the usage amount of the preservative is 0.2-0.4%, namely 0.2-0.4 g of the preservative is directly added into every 100mL of the gargle. The flavored sanguisorba officinalis gargle can be stored for a longer time by adding a small amount of preservative, and the quality guarantee period of the flavored sanguisorba officinalis gargle at normal temperature is three months under normal conditions.

Further, the preservative comprises sodium benzoate.

Further, the water used in step 2 and step 3 is purified water.

Specific preferred examples are provided herein.

The first embodiment is as follows:

a preparation method of flavored sanguisorba officinalis gargle for treating oral mucositis comprises the following specific steps:

wherein each part is 1g, 30g of sanguisorba officinalis, 30g of purslane, 15g of dark plum fruit, 5g of coptis chinensis, 10g of scutellaria baicalensis, 15g of madder root, 15g of forsythia suspensa, 15g of honeysuckle, 25g of raw liquorice, 30g of gypsum, 20g of lucid ganoderma, 30g of dandelion and 30g of radix zanthoxyli are actually weighed and uniformly mixed; the amount of the prepared decoction pieces is 100mL correspondingly.

Step 2: weighing 600g of water (600mL of water is 6 times of the amount of decoction pieces) according to the weight part ratio, adding the water into the mixed raw materials in the step 1, soaking for 30min, heating, decocting with strong fire until the mixture is boiled, continuing to decoct with slow fire for 30min, stopping heating, filtering, and taking the first filtrate for later use;

and step 3: weighing 400g of water (400mL of water is 4 times of decoction pieces) according to the weight part ratio, adding the water into the filter residue after the first filtrate is extracted, decocting with strong fire until the water is boiled, continuing to decoct with slow fire for 30min, stopping heating, and filtering to obtain a second filtrate;

and 4, step 4: and combining the first filtrate and the second filtrate, continuing decocting, and concentrating to obtain the flavored sanguisorba officinalis gargle with the concentration of 1.4 g/mL.

And 5: and (4) adding a preservative into the flavored sanguisorba officinalis gargle prepared in the step (4) and uniformly stirring, wherein the usage amount of the preservative is 0.3%, namely 0.3g of the preservative is directly added into each 100mL of the flavored sanguisorba officinalis gargle.

The using method comprises the following steps: cleaning oral cavity with clear water, adding the flavored radix Sangusorbae collutory into oral cavity three times a day, each time for 10-30 min; part of patients can be orally administered. The efficacy is as follows: clearing away heat and toxic material, healing sore, promoting granulation and relieving pain. The main treatment is as follows: oral mucositis, recurrent oral ulcer, gingival swelling and pain, and halitosis after radiotherapy and chemotherapy; contraindications: pregnant women, patients with malignant oral tumor, and patients with spleen-stomach deficiency cold.

The second embodiment is as follows:

step 1: weighing 30 parts of garden burnet, 30 parts of purslane, 25 parts of dark plum fruit, 10 parts of coptis chinensis, 15 parts of scutellaria baicalensis, 20 parts of madder root, 30 parts of weeping forsythia, 30 parts of honeysuckle, 30 parts of raw liquorice, 50 parts of gypsum, 20 parts of lucid ganoderma, 30 parts of dandelion and 30 parts of radix zanthoxyli according to the weight part ratio; wherein each part is 1g, 30g of sanguisorba officinalis, 30g of purslane, 25g of dark plum fruit, 10g of coptis chinensis, 15g of scutellaria baicalensis, 20g of madder root, 30g of forsythia suspensa, 30g of honeysuckle, 30g of raw liquorice, 50g of gypsum, 20g of lucid ganoderma, 30g of dandelion and 30g of radix zanthoxyli are actually weighed and uniformly mixed; the amount of the prepared decoction pieces is 100mL correspondingly.

Step 2: weighing 700g of water (700mL of water is 7 times of the amount of decoction pieces) according to the weight part ratio, adding the water into the mixed raw materials in the step 1, soaking for 45min, heating, decocting with strong fire until the mixture is boiled, continuing to decoct with slow fire for 30min, stopping heating, filtering, and taking the first filtrate for later use;

The third concrete embodiment:

step 1: weighing 30 parts of garden burnet, 30 parts of purslane, 25 parts of dark plum fruit, 10 parts of coptis chinensis, 10 parts of scutellaria baicalensis, 15 parts of madder root, 15 parts of weeping forsythia, 15 parts of honeysuckle flower, 25 parts of raw liquorice, 50 parts of gypsum, 20 parts of lucid ganoderma, 30 parts of dandelion and 30 parts of radix zanthoxyli according to the weight parts; wherein each part is 1g, 30g of sanguisorba officinalis, 30g of purslane, 25g of dark plum fruit, 10g of coptis chinensis, 10g of scutellaria baicalensis, 15g of madder root, 15g of forsythia, 15g of honeysuckle, 25g of raw liquorice, 50g of gypsum, 20g of lucid ganoderma, 30g of dandelion and 30g of radix zanthoxyli are actually weighed and uniformly mixed; the amount of the prepared decoction pieces is 100mL correspondingly.

Step 2: weighing 600g of water (6 times of 700mL of water in amount of the instant tablets) according to the weight part ratio, adding the water into the mixed raw materials in the step 1, soaking for 30min, heating, decocting with strong fire until the mixture is boiled, continuing to decoct with slow fire for 45min, stopping heating, filtering, and taking the first filtrate for later use;

and step 3: weighing 400g of water (400mL of water is 4 times of decoction pieces) according to the weight part ratio, adding the water into the filter residue after the first filtrate is extracted, decocting with strong fire until the water is boiled, continuing to decoct with slow fire for 45min, stopping heating, and filtering to obtain a second filtrate;

Clinical cases

1. After nasopharyngeal carcinoma radiotherapy

Patients should be dandy, after nasopharyngeal carcinoma is confirmed in 2019 and 5 months, radiotherapy is performed in tumor hospitals in Shenzhen city, after radiotherapy is completed, oral mucositis is outbreaked, the patients cannot eat food, a stomach tube is left, the patients are not completely relieved after modern medical treatment, and the patients are treated with the stomach tube in our hospital. The symptoms are red face, burning mouth and pain, and difficulty in eating and sleeping. Four diagnostic methods of traditional Chinese medicine: the tongue is bright red without coating, the oral mucosa is mostly ulcerated, the tongue is congested and red, and the pulse is thready and rapid. After the patient is admitted, the gargle with the added garden burnet is used for gargling three times a day, 15 minutes is carried out once every other day, the pain of the oral cavity of the patient can be relieved and the patient can fall asleep, the pain can be fully relieved on the fifth day and the patient can eat liquid food, and the ulcer surface of the oral mucosa is fully healed. After two days, the stomach tube is pulled out, normal food can be taken, discharge is arranged, the gargle with the flavored sanguisorba is discharged from the hospital, and the curative effect is strengthened.

2. After radiotherapy of hypopharyngeal carcinoma

The patient is aged, hypopharynx cancer is diagnosed in 2019 in 7 months, radiation therapy is performed in Shenzhen tumor hospital, after the radiation therapy is completed, oral mucositis cannot eat, and the oral mucositis is not relieved after symptomatic support therapy, traditional Chinese medicine therapy is sought, and the patient is diagnosed in our hospital with the symptoms: the stomach tube is left, the oral cavity is burnt and painful, the mouth is opened, the swallowing is difficult, the words are not spitted, and the skin below the cheekbone and at the laryngeal prominence is red and swollen; four diagnostic methods of traditional Chinese medicine: failure to stretch the tongue, red tongue tip, ulcerated tongue surface, no coating, and thready and rapid pulse. The modified sanguisorba gargle is gargled three times a day for 15 minutes once, the pain is relieved on the next day, the user can talk, eat, pull out a stomach tube and discharge 5 agents with the medicines for consolidation after three days.

3. Arterial perfusion chemotherapy for pancreatic cancer

The patients are old, pancreas malignant tumors are diagnosed in Xiangya Hospital of Zhongnan university at 12 and 25 months in 2018, the patients are perfused with gemcitabine and cinobufagin in the action pulse, and are orally taken with Hiluoda, and on the 8 th day, the patients have multiple ulcers, pains, mouth opening difficulties, red tongue, thin and greasy fur and thready and slow pulse. The modified sanguisorba gargle is used for gargling, the pain of a patient is completely relieved on the next day, the patient continues to gargle for 7 days and takes orally, the oral capecitabine treatment course is completed, the oral ulcer recurs in the subsequent treatment course, the effect is still obtained by gargling and taking orally by using the formula, and the subsequent multi-course treatment is completed.

4. After nasopharyngeal carcinoma chemotherapy

Zhengqi, the nasopharyngeal carcinoma III stage is confirmed in Zhongshan university 10 months in 2019, cisplatin +5-FU chemotherapy is performed, oral mucositis is developed after chemotherapy, multiple oral ulcers, pain is difficult to endure, mouth opening is difficult, words are not clear, eating is difficult, nutrition support is given, electrolytes are corrected, and relief after symptomatic treatment of inflammation is not obvious; in the four diagnostic methods of traditional Chinese medicine, the tongue tip is red, the coating is thin and yellow, the pulse is thin and rapid, and the oral mucosa of the gum is subjected to multiple ulcers. The gargle containing the modified sanguisorba officinalis gargle is used for gargling for 15 minutes three times a day, the pain is completely relieved in 5 days, most of the ulcer is healed, the gargle can be eaten, and the gargle is taken out of a hospital to consolidate the curative effect. After the patient is subjected to subsequent chemotherapy, oral mucositis repeatedly erupts, but the patient is cured by gargling and orally taking the gargle containing the modified sanguisorba officinalis gargle according to symptomatic support.

5 in the Targeted therapy of Lung cancer

Chen and woman, 55 years old, visit 5 months in 2020, the patient repeatedly coughs for half a year, aggravates for half a month with hemoptysis, carries out chest CT examination after hospital admission, finds the right upper lung occupation, carries out lung tumor puncture biopsy after evaluating postoperative indication, and has definite diagnosis of postoperative pathology: adenocarcinoma. And further carrying out gene detection to prompt EGFR mutation, and taking gefitinib orally one day according to the medication prompt, wherein the patient has oral ulcer, difficulty in eating, intolerable pain, incapability of falling asleep at night and obvious weight loss during the period of taking the gefitinib right after the administration. In the palpation with writing, the tongue is red, the coating is thin, and the pulse is thready and rapid. The gargle containing the added sanguisorba officinalis gargle is used for gargling, the pain is completely relieved once for 15 minutes three times a day, 2 days are prolonged, most of ulcer can be healed, liquid food can be taken, and five days later, oral mucositis is completely healed. If gefitinib is continuously taken, cough is gradually reduced, and hemoptysis is stopped. The oral mucositis does not relapse, the eating is gradually normal, and the weight is gradually restored to be normal.

6 recurrent aphthous ulcer

Chen Shi, male, 35 years old, and repeated dental ulcer were diagnosed in the pen in 6 months of 2020, and the patient complained of the recent repeated onset of dental ulcer, had difficulty in suffering pain, had been taken with food and was already treated in his hospital by the stomatological department before the diagnosis, and could not be relieved. When the doctor visits the doctor with the pen, ulcer is found on the oral mucosa and ulcer is also found on the tongue tip. The tongue is red, the coating is thin and yellow, and the pulse is smooth and rapid. The gargle containing the modified sanguisorba officinalis gargle is used for gargling, the gargle is used for 15 minutes once three times a day, most of pain is relieved in the day, the patient is particularly happy after the three days, so that the gargle is used as much before, and the traditional Chinese medicine gargle has the advantages of quick response, no stimulation in taste and sweet taste. After the return visit, three bottles are opened, half is gargled, and half is orally taken. The patient had a visit to the applicant again after several months and was still a mouth ulcer, but the patient was said to have a much longer time interval between attacks, not multiple blooms, but only one ulcer. Several bottles are required to be opened to continue gargling. This time again, the patient is advised to rinse his mouth half and take his oral half. The latter patient is asked about the canker sore because he is at a visit with the pen, so that the recurrence is greatly reduced. Order the patient to stay up at night, and have light and nutritious diet and less pungency.

The above embodiments are merely illustrative of the preferred embodiments of the present invention, and not restrictive, and various changes and modifications to the technical solutions of the present invention may be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are intended to fall within the scope of the present invention defined by the appended claims.

Claims

1. The flavored sanguisorba gargle for treating oral mucositis is characterized by being prepared from the following raw materials in parts by weight: 10-30 parts of garden burnet, 10-30 parts of purslane, 15-25 parts of dark plum fruit, 5-10 parts of coptis chinensis, 5-15 parts of scutellaria baicalensis, 10-20 parts of madder root, 10-30 parts of weeping forsythia, 10-30 parts of honeysuckle flower, 15-30 parts of raw liquorice, 20-50 parts of gypsum, 10-20 parts of lucid ganoderma, 15-30 parts of dandelion, 15-30 parts of radix zanthoxyli, 1200 parts of water and 1200 parts of preservative.

2. A method of preparing the flavored sanguisorba officinalis mouthrinse solution for treating oral mucositis of claim 1, wherein the method comprises the steps of: the method comprises the following steps:

and 4, step 4: mixing the first filtrate and the second filtrate, decocting, and concentrating to obtain flavored radix Sangusorbae collutory with concentration of 1.2-1.6 g/mL;

3. The preparation method of the flavored sanguisorba officinalis gargle for treating oral mucositis according to claim 2, which is characterized in that: wherein the water used in step 2 and step 3 is purified water.

4. The preparation method of the flavored sanguisorba officinalis gargle for treating oral mucositis, according to claim 2, is characterized in that: the specific steps of the step 2 are as follows: weighing 700 parts of purified water by weight, adding the purified water into the mixed raw materials obtained in the step 1, soaking for 15-45 min, heating, decocting with strong fire until boiling, continuing to decoct with slow fire for 20-45 min, stopping heating, filtering, and taking the primary filtrate for later use.