CN112716833A - Mild nipple cream and preparation method thereof - Google Patents
Mild nipple cream and preparation method thereof Download PDFInfo
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- CN112716833A CN112716833A CN202110060476.4A CN202110060476A CN112716833A CN 112716833 A CN112716833 A CN 112716833A CN 202110060476 A CN202110060476 A CN 202110060476A CN 112716833 A CN112716833 A CN 112716833A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/0229—Sticks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Birds (AREA)
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Abstract
The invention discloses mild nipple cream and a preparation method thereof. The mild nipple cream comprises the following emollients in parts by weight: 20-70 parts of lanolin, 3-15 parts of coconut oil, 5-40 parts of olive oil and 0.5-1.5 parts of glyceryl caprylate. According to the invention, lanolin, coconut oil, olive fruit oil and glyceryl caprylate are added as components of the emollient, and the components are compounded and synergized by utilizing the strong repairing and moisturizing performances of lanolin, the mellow coconut fragrance and moisturizing performances of coconut oil, the ductility and moisturizing performances of olive fruit oil and the antibacterial and moisturizing performances of glyceryl caprylate, so that the performances of repairing, moisturizing, bacteriostasis and preventing dry cracking are realized. Meanwhile, the combination of stearyl alcohol glycyrrhetinate can effectively inhibit NF-kB and TNF-alpha and reduce allergy. The mild nipple cream prepared by the formula components and the preparation method is pasty, can be made into a rod-shaped product, is convenient to use, and reduces pollution caused by hand smearing.
Description
Technical Field
The invention belongs to the field of skin care products, relates to a skin care product, and particularly relates to mild nipple cream and a preparation method thereof.
Background
The nipple cream is a breast care product for mothers, and has the functions of moistening skin, and effectively preventing nipple rupture and other skin dryness. The nipple ointment has the action principle of moisturizing therapy, keeps moist and promotes wound healing, certain humidity is required for cell growth in the wound healing process, the wound healing speed is improved by 50% in a moist environment, and moisturizing nursing of the wound provides an optimal environment for wound healing. However, the currently marketed products have the following disadvantages:
(1) most of the products sold in the market at present are cream-shaped or full-fat, and are sticky when in use;
(2) at present, products sold in the market are basically packaged in extrusion bottles, and the products are extruded firstly and then smeared by hands when used, so that the products are inconvenient to use, and the hands are easy to pollute if not cleaned;
(3) most products only have the functions of supplementing water and repairing, but infants bite nipples forcibly, and the epidermis is soaked by saliva for a long time to become soft, stripped and eroded, so that allergy is easily caused;
(4) because newborns are sensitive to essence, the products are not added with essence basically, and the selected raw materials such as mutton tallow are heavy in taste.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides the mild nipple cream and the preparation method thereof, and lanolin, coconut oil, olive oil and glyceryl caprylate are compounded for synergistic interaction, so that the performances of repairing, moisturizing, bacteriostasis, refreshing, preventing chapping and having faint scent taste are realized.
In order to achieve the purpose, the invention adopts the technical scheme that: the mild nipple cream comprises the following emollients in parts by weight: 20-70 parts of lanolin, 3-15 parts of coconut oil, 5-40 parts of olive oil and 0.5-1.5 parts of glyceryl caprylate.
Lanolin, a secreted oil attached to wool, is a yellowish or brownish yellow ointment, sticky and greasy, and has a weak and specific odor. Lanolin can smooth and tender skin, and soften and recover skin which is dry or rough due to lack of natural moisture.
More than 85% of coconut oil is a large amount of saturated fatty acid ester, can reduce the water loss through epidermis, and has the effects of moistening and preserving skin; coconut oil has good inhibitory action on metalloprotease, and the activity of metalloprotease can be used as an index of organism aging, so that it can be used for resisting aging, and simultaneously coconut oil has mellow natural coconut fragrance, and can reduce the weak odor of lanolin.
The olive fruit oil is a natural skin-moistening oil, can deeply nourish the skin, has fragrant and elegant fragrance, shows excellent ductility on the skin, and has good moisturizing performance.
The glyceryl caprylate is commonly used as skin emollient and emulsifier, has anti-acne activity, antibacterial effect, reduces bacterial infection of application part, and protects health of infant and baby mother. The short lipophilic carbon chains of glyceryl caprylate penetrate into and adsorb on lipid part of human skin, and has good moisturizing effect on stratum corneum, and lipid-adding effect, and can transport and retain oily components on skin surface layer.
The components are compounded and synergized by utilizing the strong repairing and moisturizing performances of lanolin, the mellow coconut flavor and moisturizing performances of coconut oil, the ductility and moisturizing performances of olive oil and the bacteriostatic and moisturizing performances of glyceryl caprylate, so that the repairing, moisturizing, bacteriostatic, refreshing, anti-cracking and fragrance performances are realized.
As a preferred embodiment of the present invention, the mild teat cream comprises the following emollients in parts by weight: 49.3 parts lanolin, 9 parts coconut oil, 27 parts olive oil and 1 part glyceryl caprylate.
The mild nipple cream has the best effects of repairing, moisturizing, bacteriostasis, refreshing, preventing chapping and fragrance in the proportion.
As a preferred embodiment of the present invention, the mild teat cream further comprises the following skin conditioning agents in parts by weight: 0.03-0.4 parts of stearyl glycyrrhetinate.
The stearyl alcohol glycyrrhetinic acid ester has lipophilic higher alkanol introduced, remarkably improved solubility to oil and fat, wide compatibility in cosmetics, antibacterial, antiinflammatory, antioxidant, antiaging, ultraviolet absorbing, skin whitening, speckle removing, and moisture keeping effects.
As a preferred embodiment of the present invention, the mild teat cream further comprises the following antioxidant in parts by weight: 0.1-2.0 parts of tocopherol.
The tocopherol is a hydrolysate of vitamin E, can increase the antioxidation of cells, has certain anti-aging and anti-wrinkle effects, can improve lipid metabolism, prevent arteriosclerosis, reduce blood fat, has moisturizing and moisturizing properties, and can form a soft protective film on the surface of skin to isolate external pollution.
As a preferred embodiment of the present invention, the mild teat cream further comprises the following thickener in parts by weight: 4.5-13 parts of candelilla wax and 2-12 parts of beeswax.
According to the invention, mild candelilla wax and beeswax are used as thickening plastic agents, so that the mild nipple ointment is pasty and can be made into a rod-shaped product, on one hand, the rod-shaped product is convenient to use, and on the other hand, the pollution caused by hand application can be reduced.
As a preferred embodiment of the present invention, the mild teat cream comprises the following components in parts by weight: 49.3 parts lanolin, 9 parts coconut oil, 27 parts olive oil, 1 part glyceryl caprylate, 0.2 part stearyl glycyrrhetinate, 0.5 part tocopherol, 8.5 parts candelilla wax, and 4.5 parts beeswax.
Through a large number of experiments, the mild nipple cream disclosed by the invention has the best effects of repairing, moisturizing, inhibiting bacteria, refreshing, preventing chapping and having faint scent under the conditions of the proportion.
The invention also provides a preparation method of the mild nipple cream, which comprises the following steps:
(1) at the temperature of 90-100 ℃, adding candelilla wax, beeswax and lanolin into a reaction container, and stirring for dissolving;
(2) adding coconut oil, olive oil, glyceryl caprylate, stearyl glycyrrhetinate and tocopherol into the solution obtained in the step (1), dissolving, filtering, and cooling to obtain the mild nipple ointment.
As a preferred embodiment of the present invention, the wrapper tube is inserted into a mold, the body obtained in step (2) is poured into the wrapper tube, and cooled to obtain a mild cream nipple in the form of a stick.
The mild nipple cream prepared by controlling the components of the mild nipple cream and the addition amount of the components is pasty, so that a rod-shaped product can be prepared, on one hand, the rod-shaped product is convenient to use, on the other hand, the pollution caused by hand smearing can be reduced, and the rod-shaped product has the characteristics of natural mildness, moisture retention and bacteria resistance.
In a preferred embodiment of the present invention, in the step (1), the stirring speed is 20 rpm.
In the step (2), a 400-mesh sieve is used for filtering. Compared with the prior art, the invention has the beneficial effects that: according to the invention, lanolin, coconut oil, olive fruit oil and glyceryl caprylate are added as components of the emollient, and the strong repairing and moisturizing performances of lanolin, the mellow coconut fragrance and moisturizing performances of coconut oil, the ductility and moisturizing performances of olive fruit oil and the antibacterial moisturizing performances of glyceryl caprylate are utilized to compound the components of the emollient to realize synergistic interaction, so that the performances of repairing, moisturizing, bacteriostasis, refreshing, preventing chapping and fragrance are realized. Meanwhile, the combination of stearyl alcohol glycyrrhetinate can effectively inhibit NF-kB and TNF-alpha and reduce allergy. The mild nipple ointment prepared by the formula components and the preparation method of the invention takes mild candelilla wax and beeswax as thickening plastic agents, can be made into a rod-shaped product, is convenient to use, and reduces pollution caused by hand application.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Examples 1 to 4, comparative examples 1 to 6
The component formulations of the mild teat creams described in examples 1-4 and comparative examples 1-6 are shown in Table 1.
Table 1 mass percentage of each component in the mild teat cream (%)
The preparation method of the mild nipple cream described in examples 1 to 4 and comparative examples 1 to 6 includes the following steps:
(1) at 95 ℃, putting candelilla wax, beeswax and lanolin into a reaction container, and stirring and dissolving at the speed of 20 revolutions per minute;
(2) adding coconut oil, olive oil, glyceryl caprylate, stearyl glycyrrhetinate and tocopherol into the solution obtained in the step (1), dissolving until the solution is transparent, and filtering with a 400-mesh filter screen for later use;
(3) and (3) inserting the packaging material tube into a mold, pouring the material body obtained in the step (2) into the packaging material tube, and cooling to obtain the rod-shaped mild nipple paste.
Test example 1: performance testing
Testing the population: female volunteers aged 17-45 years, total 200 persons, divided into 10 groups of 20 persons each.
The test method comprises the following steps: volunteers were randomly grouped and tested on the lips for samples from examples 1-4 and comparative examples 1-6, respectively (one sample for each group); the dosage is 0.15 g/time and 3 times/day, and the preparation is continuously administered for one month. The self-judgment standard is that the satisfaction is 0-5 points. The score was 5 and the average of the test results is shown in Table 2.
TABLE 2 Performance testing of Mild Nipple creams
Moisture retention | Moistening degree | Refreshing property | Allergic reaction | |
Example 1 | 4.9 | 5.0 | 4.9 | Has no allergy |
Example 2 | 4.5 | 4.4 | 4.6 | Has no allergy |
Example 3 | 4.8 | 4.8 | 4.8 | Has no allergy |
Example 4 | 4.6 | 4.7 | 4.7 | Has no allergy |
Comparative example 1 | 2.8 | 3.0 | 4.3 | Has no allergy |
Comparative example 2 | 4.0 | 4.2 | 3.8 | Has no allergy |
Comparative example 3 | 4.3 | 3.8 | 3.3 | Has no allergy |
Comparative example 4 | 3.5 | 4.0 | 3.1 | Has no allergy |
Comparative example 5 | 3.9 | 4.1 | 3.8 | Slight discomfort for 1 person |
Comparative example 6 | 3.0 | 3.5 | 4.2 | Has no allergy |
As is clear from the results in Table 2, the samples of examples 1 to 4 and comparative example 6 were not allergic; the mild nipple creams prepared in examples 1-4 all have good moisturizing, moistening and refreshing effects, wherein example 1 is the best formulation. Further analyzing comparative examples 1-4, the moisturizing, moisturizing and refreshing effects of the product decreased when any one of the components was absent during the test period, indicating that lanolin, coconut oil, olive oil and glyceryl caprylate, compounded, may synergistically moisturize, moisturize and refresh the effects. Moreover, as can be seen from the test results of comparative example 5, the combination of the emollient component of the invention and stearyl glycyrrhetinate can make the product have moisturizing, moistening and refreshing properties and simultaneously have good anti-allergy effect. As can be seen from comparative example 6, the addition amount of each component of the mild nipple cream of the present invention has a great influence on the moisturizing, moistening and refreshing properties of the mild nipple cream of the present invention, indicating that the above components have good moisturizing, moistening and refreshing effects within the range defined by the present invention.
Test example 2: test of antibacterial Property
Respectively weighing 10g of the samples of example 1 and comparative example 4, putting the samples into a sterilized mortar, respectively adding 5g of common face cream without preservatives, then adding 10ml of sterilized liquid paraffin, grinding the mixture into paste, then adding 10ml of sterilized Tween 80, grinding the paste to dissolve the sterilized liquid paraffin, adding 65ml of sterilized normal saline, and fully mixing the sterilized normal saline in a water bath at 40-44 ℃ to prepare 1:10 diluent.
1. Total bacterial count determination
The test method comprises the following steps: (1) sending the sample to be detected with the written detection serial number into a sterile room;
(2) igniting the alcohol lamp, and carrying out all operations beside the alcohol flame;
(3) the test operator wears a mask and gloves, disinfects the hands by 75% alcohol, and then sterilizes the sample bottle cap (three times of flame sterilization) to uniformly mix the sample in the bottle before opening the cap. After the cover is opened, the mouth of the sample bottle is sterilized by flame for three times. Weighing 10g of sample, extruding into a triangular flask filled with 90ml of normal saline to prepare 1:10 diluent, and numbering consistent with the sample;
(4) sucking 1ml of the test solution with a sterilizing pipette, injecting into a sterilizing dish with the same number of corresponding diluent, adding another 1ml into a 9ml sterilized normal saline tube (taking care not to make the pipette contact the liquid surface), and mixing well to obtain 1:100 diluted test solution. Replacing a suction pipe, sucking 1ml of the solution and injecting the solution into another plate with a corresponding number;
(5) the lecithin, tween 80-medium cooled to 45-50 ℃ was injected into the dish. About 15ml of each dish was then rotated to mix the sample with the medium. A sterile empty dish without sample was also poured and a blank experiment was performed. And after the culture medium is completely cooled to be solidified, turning over the plate, and putting the plate into a constant-temperature incubator at 37 ℃ for culturing for 48 hours.
2. Determination of total number of mold and yeast
The test method comprises the following steps: (1) sending the sample to be detected with the written detection serial number into a sterile room;
(2) igniting the alcohol lamp, wherein all operations need to be carried out beside the flame of the alcohol lamp;
(3) the test operator wears a mask and gloves, disinfects the hands by 75% alcohol, and then sterilizes the sample bottle cap (three times of flame sterilization) to uniformly mix the sample in the bottle before opening the cap. After the cover is opened, the mouth of the sample bottle is sterilized by flame for three times. Weighing 10g of sample, extruding into a triangular flask filled with 90ml of normal saline to prepare 1:10 diluent, and numbering consistent with the sample;
(4) sucking 1ml of the test solution with a sterilizing pipette, injecting into a sterilizing dish with the same number of corresponding diluent, adding another 1ml into a 9ml sterilized normal saline tube (taking care not to make the pipette contact the liquid surface), and mixing well to obtain 1:100 diluted test solution. Replacing a suction pipe, sucking 1ml of the solution and injecting the solution into another plate with a corresponding number;
(5) the Bengal red medium cooled to 45-50 ℃ was poured into a dish containing the diluted test solution. About 15ml of each dish was then rotated to mix the sample with the medium. A sterile empty dish without sample was also poured and a blank experiment was performed. And after the culture medium is completely cooled to be solidified, turning the plate, and putting the plate upside down into a constant-temperature incubator at 28 ℃ for culturing for 120 hours.
TABLE 3 microbiological testing of Mild Nipple creams
From the test results, both example 1 and comparative example 4 met the use criteria (total number of bacteria ≦ 100 cfu/g; total number of enzyme bacteria and yeast ≦ 10 cfu/g). The product is easily affected by external factors and microorganism in the using process, and the glyceryl caprylate is used as a mild humectant, has good antibacterial effect and can effectively prevent the growth of microorganisms brought by the outside.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (7)
1. The mild nipple cream is characterized by comprising the following emollients in parts by weight: 20-70 parts of lanolin, 3-15 parts of coconut oil, 5-40 parts of olive oil and 0.5-1.5 parts of glyceryl caprylate.
2. The mild teat cream of claim 1 comprising the following emollient in parts by weight: 49.3 parts lanolin, 9 parts coconut oil, 27 parts olive oil and 1 part glyceryl caprylate.
3. The mild teat cream of claim 1 or 2, further comprising the following skin conditioning agents in parts by weight: 0.03-0.4 parts of stearyl glycyrrhetinate.
4. The mild teat cream of claim 1 or 2, further comprising an antioxidant in parts by weight: 0.1-2.0 parts of tocopherol.
5. The mild teat cream of claim 1 or 2, further comprising a thickener in the following parts by weight: 4.5-13 parts of candelilla wax and 2-12 parts of beeswax.
6. The mild teat cream of claim 1 comprising the following components in parts by weight: 49.3 parts lanolin, 9 parts coconut oil, 27 parts olive oil, 1 part glyceryl caprylate, 0.2 part stearyl glycyrrhetinate, 0.5 part tocopherol, 8.5 parts candelilla wax, and 4.5 parts beeswax.
7. The method for preparing mild nipple cream according to claim 6, comprising the steps of:
(1) adding candelilla wax, beeswax and lanolin into a reaction container at 90-100 deg.C, stirring and dissolving;
(2) adding coconut oil, olive oil, glyceryl caprylate, stearyl glycyrrhetinate and tocopherol into the solution obtained in the step (1), dissolving, filtering, and cooling to obtain the mild nipple ointment.
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Citations (4)
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CN106109324A (en) * | 2016-07-31 | 2016-11-16 | 唐玥琳 | Skin-moisturizing, skin emulsion |
CN106265151A (en) * | 2016-08-24 | 2017-01-04 | 登封市科技企业孵化服务中心 | Oleum Cocois skin care day cream |
CN109091421A (en) * | 2018-11-01 | 2018-12-28 | 广州市华晟健康产业有限公司 | A kind of infant's soothing oil |
CN111557867A (en) * | 2020-04-21 | 2020-08-21 | 上海纽因贝母婴用品有限公司 | Infant soothing cream and preparation method thereof |
-
2021
- 2021-01-15 CN CN202110060476.4A patent/CN112716833A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106109324A (en) * | 2016-07-31 | 2016-11-16 | 唐玥琳 | Skin-moisturizing, skin emulsion |
CN106265151A (en) * | 2016-08-24 | 2017-01-04 | 登封市科技企业孵化服务中心 | Oleum Cocois skin care day cream |
CN109091421A (en) * | 2018-11-01 | 2018-12-28 | 广州市华晟健康产业有限公司 | A kind of infant's soothing oil |
CN111557867A (en) * | 2020-04-21 | 2020-08-21 | 上海纽因贝母婴用品有限公司 | Infant soothing cream and preparation method thereof |
Non-Patent Citations (1)
Title |
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佚名: "羊毛脂功效和作用", 《百度》 * |
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