CN112691077B - Processing method of glucose injection - Google Patents
Processing method of glucose injection Download PDFInfo
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- CN112691077B CN112691077B CN202011604061.0A CN202011604061A CN112691077B CN 112691077 B CN112691077 B CN 112691077B CN 202011604061 A CN202011604061 A CN 202011604061A CN 112691077 B CN112691077 B CN 112691077B
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- aqueous solution
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- silk fibroin
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 55
- 229940093181 glucose injection Drugs 0.000 title claims abstract description 23
- 238000003672 processing method Methods 0.000 title claims abstract description 19
- 239000007864 aqueous solution Substances 0.000 claims abstract description 164
- 108010022355 Fibroins Proteins 0.000 claims abstract description 65
- 238000002156 mixing Methods 0.000 claims abstract description 64
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 61
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 61
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 61
- 239000000661 sodium alginate Substances 0.000 claims abstract description 61
- 239000000463 material Substances 0.000 claims abstract description 53
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 50
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 50
- 239000008103 glucose Substances 0.000 claims abstract description 32
- 239000003814 drug Substances 0.000 claims abstract description 29
- 239000011259 mixed solution Substances 0.000 claims abstract description 12
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229920001983 poloxamer Polymers 0.000 claims abstract description 10
- 229960000502 poloxamer Drugs 0.000 claims abstract description 10
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 8
- 239000002775 capsule Substances 0.000 claims abstract description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 8
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims abstract description 4
- 240000009138 Curcuma zedoaria Species 0.000 claims abstract description 4
- 235000003405 Curcuma zedoaria Nutrition 0.000 claims abstract description 4
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 4
- 235000017471 coenzyme Q10 Nutrition 0.000 claims abstract description 4
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims abstract description 4
- 229940110767 coenzyme Q10 Drugs 0.000 claims abstract description 4
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 claims abstract description 4
- 238000001914 filtration Methods 0.000 claims abstract description 4
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000012528 membrane Substances 0.000 claims abstract description 4
- 238000010008 shearing Methods 0.000 claims abstract description 4
- 230000001954 sterilising effect Effects 0.000 claims abstract description 4
- 239000010681 turmeric oil Substances 0.000 claims abstract description 4
- 238000002604 ultrasonography Methods 0.000 claims abstract description 4
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 4
- 229940046009 vitamin E Drugs 0.000 claims abstract description 4
- 239000011709 vitamin E Substances 0.000 claims abstract description 4
- 235000019509 white turmeric Nutrition 0.000 claims abstract description 4
- 238000005192 partition Methods 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 238000006386 neutralization reaction Methods 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 description 19
- 229940079593 drug Drugs 0.000 description 6
- 239000003094 microcapsule Substances 0.000 description 6
- 239000003012 bilayer membrane Substances 0.000 description 3
- 229940090044 injection Drugs 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000002502 liposome Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000010410 layer Substances 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/60—Pump mixers, i.e. mixing within a pump
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Abstract
The invention discloses a processing method of a glucose injection, the glucose injection comprises a fat-soluble medicine and a capsule wall material, and the capsule wall material comprises the following components in parts by weight: 15-45 parts of sodium alginate, 1882.5-9 parts of poloxamer, 1.5-5 parts of silk fibroin, 0.5-3 parts of polyvinyl alcohol and 0.2-3 parts of polyethylene glycol, wherein the glucose accounts for 5% of the total volume by mass; the fat-soluble medicine is zedoary turmeric oil, vitamin E or coenzyme Q10, the weight portion is 15-45 portions, and the processing method comprises the following steps: preparing a sodium alginate aqueous solution, a silk fibroin aqueous solution and a polyvinyl alcohol aqueous solution; mixing a sodium alginate aqueous solution, a silk fibroin aqueous solution, a polyvinyl alcohol aqueous solution and glucose by using a mixing device to obtain a mixed solution A; adding poloxamer and polyethylene glycol into the mixed solution A, uniformly mixing, and finally dropwise adding a fat-soluble medicine to obtain a mixed solution B; treating with ultrasound and shearing, filtering with 450nm membrane, and sterilizing with damp heat to obtain glucose injection.
Description
Technical Field
The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a processing method of a glucose injection.
Background
The pharmacological activity of the fat-soluble medicine is obvious, the effective components are easy to be oxidized and deteriorated to influence the medicine property, and the solubility in the human body internal environment is low, so that the effective concentration of the medicine is difficult to achieve. Therefore, the clinical commonly used solubilizer improves the stability and solubility of the fat-soluble medicine, realizes targeting, improves the bioavailability of the medicine and reduces toxic and side effects.
When the bilayer membrane liposome is used as a water-soluble drug delivery system, the problem of thermodynamic instability still exists, but when the bilayer membrane liposome is applied to fat-soluble drugs, the bilayer membrane liposome is in a monolayer form, and the stability becomes extremely poor. Poloxamer has good biocompatibility but poor stability, and is mainly tween-80 in the application of clinical fat-soluble medicine injection, but has higher hemolysis risk, and the application range and the medicine concentration of the medicine are limited. At present, the market lacks an injection preparation with high safety, high stability and high drug-loading rate, so that the search for a preparation method of a fat-soluble drug injection preparation with higher safety, stability and high drug-loading rate is particularly important.
Disclosure of Invention
The invention provides a processing method of a glucose injection to overcome the defects of the prior art.
In order to achieve the purpose, the invention adopts the following technical scheme: a processing method of a glucose injection comprises a fat-soluble medicine and a capsule wall material, wherein the capsule wall material comprises the following components in parts by weight: 15-45 parts of sodium alginate, 2.5-9 parts of poloxamer, 1.5-5 parts of silk fibroin, 0.5-3 parts of polyvinyl alcohol and 0.2-3 parts of polyethylene glycol; the fat-soluble medicine is zedoary turmeric oil, vitamin E or coenzyme Q10, and the weight parts of the medicine are 15-45 parts; the glucose which accounts for 5 percent of the total volume is also included, and the method comprises the following steps:
step a: preparing a sodium alginate aqueous solution, a silk fibroin aqueous solution and a polyvinyl alcohol aqueous solution; step b: mixing a sodium alginate aqueous solution, a silk fibroin aqueous solution, a polyvinyl alcohol aqueous solution and glucose by using a mixing device to obtain a mixed solution A;
step c: adding poloxamer and polyethylene glycol into the mixed solution A, uniformly mixing, and finally dropwise adding a fat-soluble medicine to obtain a mixed solution B;
step d: treating with ultrasound and shearing, filtering with 450nm membrane, and sterilizing with damp heat to obtain glucose injection;
the mixing device in the step b comprises a neutralization mixing pump, a mixing sleeve matched with the neutralization mixing pump and a third connecting pipe for connecting the neutralization mixing pump with the first feeding pipe, wherein the mixing sleeve is provided with four layers, and sodium alginate aqueous solution, silk fibroin aqueous solution, polyvinyl alcohol aqueous solution and glucose are sequentially supplied from outside to inside; the mixed sleeve comprises a first pipe body, a second pipe body arranged in the first pipe body, a third pipe body arranged in the second pipe body, a fourth pipe body arranged in the third pipe body, a plurality of groups of first hole groups arranged on the second pipe body, a plurality of groups of second hole groups arranged on the third pipe body, a plurality of groups of third hole groups arranged on the fourth pipe body, a first shunt assembly arranged at the first end first hole group, a second shunt assembly arranged at the second end second hole group, a third shunt assembly arranged at the third end hole group, a first clapboard and a second clapboard arranged between the first pipe body and the second pipe body, a third clapboard, a fourth clapboard, a fifth clapboard and a sixth clapboard arranged between the second pipe body and the third pipe body, a seventh clapboard, an eighth clapboard, a ninth clapboard and a tenth clapboard arranged between the third pipe body and the third pipe body, the two adjacent first hole groups are symmetrically arranged and consist of a plurality of first arc-shaped holes which are distributed on the second pipe body in an annular mode at equal intervals; the sodium alginate aqueous solution between the first tube body and the second tube body enters between the second tube body and the third tube body through the first hole group at the head end by the arrangement of the first partition plate, and is mixed with the silk fibroin aqueous solution in the second tube body and the third tube body, the sodium alginate aqueous solution and the silk fibroin aqueous solution are rapidly mixed through the first shunt assembly at the head end, the sodium alginate aqueous solution and the silk fibroin aqueous solution are rapidly mixed through the second hole group at the head end after being mixed through the third partition plate, the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution are rapidly mixed through the second shunt assembly at the head end, the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution are rapidly mixed through the third hole group at the head end after being mixed through the seventh partition plate, the mixed sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution enter into the fourth tube body through the third hole group at the head end, the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution are mixed through the third shunt assembly, The silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose are quickly mixed, the mixed four materials return to a position between a fourth pipe body and a third pipe body through a third hole group adjacent to a head end third hole group, sequentially pass through a second hole group adjacent to the head end second hole group and a first hole group adjacent to the head end first hole group, sequentially enter a position between the third pipe body and the second pipe body and a position between the first pipe body and the second pipe body, the first hole group, the second hole group and the third hole group are multiple, the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose are mixed through a first partition plate to a tenth partition plate, the mixed four materials continuously return to and fro between the first pipe body and the second pipe body, between the second pipe body and the third pipe body, between the third pipe body and the fourth pipe body and in the fourth pipe body, thereby prolonging the flow length of the mixed four materials and leading the mixed four materials to have better mixing and neutralizing effect, and further mixing by a mixing pump.
Preferably, the mixing sleeve further comprises a plurality of first rod bodies which are distributed in an equidistant annular manner, penetrate through the second partition plate and are fixedly arranged on the first partition plate at one end, a plurality of second rod bodies which are distributed in an equidistant annular manner, penetrate through the fourth partition plate, the fifth partition plate and the sixth partition plate and are fixedly arranged on the third partition plate at one end, and a plurality of third rod bodies which are distributed in an equidistant annular manner, penetrate through the eighth partition plate, the ninth partition plate and the tenth partition plate and are fixedly arranged on the seventh partition plate at one end; the arrangement of the first rod body leads the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose which enter between the first pipe body and the second pipe body to be shunted, thereby having good mixing effect, the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose which enter between the second tube body and the third tube body are shunted through the arrangement of the second rod body, so that a good mixing effect is achieved, the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose which enter between the fourth tube body and the third tube body are shunted by the arrangement of the third tube body, so that a good mixing effect is achieved, the mixing efficiency and effect can be greatly improved through the flow division and mixing of the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose for many times in the flowing process, and the mixing process does not need to be stopped.
Preferably, the mass fraction of the sodium alginate aqueous solution is 0.5-2.0%, the mass fraction of the silk fibroin aqueous solution is 0.5-2%, and the mass fraction of the polyvinyl alcohol aqueous solution is 0.5-2%.
Preferably, the first flow distribution assembly comprises a first conical plate, a first cavity arranged in the first conical plate, a plurality of first water outlet pipes which are distributed on the first conical plate in an annular manner at equal intervals, a plurality of second water outlet pipes which are arranged on the first conical plate in a penetrating manner, a first fixing ring fixedly arranged on the inner wall of the second pipe body, a plurality of flow distribution plates which are distributed on the first fixing ring in an annular manner at equal intervals and fixedly arranged on the first fixing ring, and a first through hole arranged in the middle of the flow distribution plates; the sodium alginate aqueous solution enters the first cavity in the first conical plate through the plurality of first arc-shaped holes, is discharged through the plurality of first water outlet pipes on the first cavity and then enters between the second pipe body and the third pipe body, the silk fibroin aqueous solution between the second pipe body and the third pipe body is discharged through the plurality of second water outlet pipes, the flow velocity of the sodium alginate aqueous solution discharged from the first water outlet pipe from the outside of the inner channel is sequentially increased through the arrangement of the first conical plate, the silk fibroin aqueous solution discharged from the second water outlet pipe from the outside of the inner channel is sequentially increased, the first fixing ring is arranged to mix the two to form a vortex, the mixing effect of the two is improved, the two flow to the two sides of the first fixing ring and the second fixing ring are enabled to flow through the plurality of flow distribution plates, one part of the two flow through the first through holes on the first fixing ring, and the first water outlet pipe and the second water outlet pipe are arranged in a staggered manner, so that the mixing effect of the first water outlet pipe and the second water outlet pipe can be greatly improved.
Preferably, the third shunting assembly comprises a rotating shaft arranged at the axis of the fourth pipe body, a first shaft sleeve fixedly sleeved on the rotating shaft, a second shaft sleeve rotatably sleeved on the rotating shaft and fixedly arranged on the inner wall of the fourth pipe body, a second fixing ring fixedly arranged on the inner wall of the fourth pipe body, a second through hole arranged in the middle of the second fixing ring, a vortex-shaped current collecting plate fixedly arranged on the rotating shaft, a circular plate fixedly sleeved on the rotating shaft, a plurality of inclined plates equidistantly arranged on the vortex-shaped current collecting plate, a third through hole arranged at one end of each inclined plate on the vortex-shaped current collecting plate, and a fourth through hole arranged at the other end of each inclined plate on the vortex-shaped current collecting plate; the rotation of the rotating shaft is driven by the neutralization mixing pump, so that the vortex-shaped flow gathering plate on the rotating shaft rotates, glucose in the fourth pipe body passes through the space between the fourth pipe body and the circular plate and is mixed with the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution which enter through the third hole group, the four mixed materials flow to the middle of the vortex-shaped flow gathering plate in the rotation process of the vortex-shaped flow gathering plate and flow to the first shaft sleeve from the second through hole in the middle of the fixing ring, the four mixed materials are gathered and mixed, the flow direction of the four mixed materials can be changed by arranging the inclined plates on the four inclined plates, the four mixed materials have good mixing effect integrally, the resistance borne in the rotation process of the vortex-shaped flow gathering plate can be reduced by the third through hole and the fourth through hole, the flow speed of the four mixed materials can be improved by the third through hole and the fourth through hole, and the mixing effect at the third through hole and the fourth through hole can be improved, it is more steady to set up through first axle sleeve and second axle sleeve to make the pivot rotate the in-process, reduces and rotates rocking of in-process, improves the life of pivot, and four flow from the second through-hole to first axle sleeve direction flow after gathering through vortex form current board, shunts four again through first axle sleeve, gathers to flow promptly and assaults the mixture, shunts four again, has improved mixed effect and efficiency to four greatly.
Preferably, the first shaft sleeve comprises a sleeve body, a first conical body fixedly arranged at one end of the sleeve body, a fixed plate fixedly arranged on the first conical body in an equidistant annular distribution manner, a driven shaft rotatably arranged on the fixed plate, a second conical body fixedly arranged on the driven shaft in a fixed manner, a hollow pipe fixedly arranged on the driven shaft in a fixed manner, a plurality of fifth through holes and sixth through holes which are annularly distributed at equal intervals on the hollow pipe, and a conical ring fixedly arranged at one end of the hollow pipe; the rotating shaft drives the first shaft sleeve to rotate in the rotating process, the sleeve body rotates, the first conical body rotates, the plurality of fixing plates on the first conical body revolve around the rotating shaft as an axis, the four mixed materials flowing through the position can flow outwards through the arrangement of the first conical body, one part of the mixed materials directly enter the hollow pipe in the flowing process and the other part of the mixed materials directly enter the hollow pipe through the fifth through hole, so that the mixed materials are impacted and mixed with the four mixed materials directly entering the hollow pipe, the mixed materials in the hollow pipe are discharged through the sixth through hole and flow through the second conical body to be shunted outwards again, and the mixed materials are arranged on the fixing plates in a rotating mode through the driven shaft, so that the hollow pipe can rotate, the four mixed materials in the hollow pipe are mixed more easily, one part of the mixed materials in the hollow pipe can flow out from other fifth through holes, and the resistance force applied in the revolution process of the hollow pipe can be reduced, the four groups can be mixed more comprehensively when flowing through the position through the revolution of the hollow pipe.
In conclusion, the fat-soluble medicine sub-microcapsule glucose injection is a stable system, the solution is clear and transparent after centrifugation, no layering and no suspension liquid exist, the sub-microcapsule system is uniformly wrapped, and the particle size of the sub-microcapsule is uniform; the addition of the sub-microcapsule material poloxamer is safe and nontoxic, and can effectively improve the uniformity and stability of the microcapsule; the technical problems of low safety, poor stability and low drug loading rate of the conventional fat-soluble drug sub-microcapsule are solved, the raw materials of the glucose injection prepared by the mixing device are mixed more uniformly, so that the glucose injection has good compatibility with blood, and the problem of the fat-soluble glucose injection with higher safety, stability and drug loading rate is better solved.
Drawings
Fig. 1 is a cross-sectional view of the present invention.
Fig. 2 is an enlarged view of a portion a in fig. 1.
Fig. 3 is an enlarged view of fig. 1 at B.
Fig. 4 is a partial sectional view taken along line B-B of fig. 1.
Fig. 5 is a partial sectional view taken along line C-C of fig. 1.
Fig. 6 is a partial sectional view taken along line D-D in fig. 1.
Fig. 7 is a cross-sectional view taken along line E-E of fig. 1.
Fig. 8 is a sectional view taken along line F-F in fig. 1.
Fig. 9 is an enlarged view of fig. 8 at C.
Fig. 10 is a schematic structural view of the second tube.
Detailed Description
As shown in fig. 1-10, a processing method of a glucose injection, the glucose injection comprises a fat-soluble drug and a capsule wall material, and the capsule wall material comprises the following components in parts by weight: 15-45 parts of sodium alginate, 2.5-9 parts of poloxamer, 1.5-5 parts of silk fibroin, 0.5-3 parts of polyvinyl alcohol and 0.2-3 parts of polyethylene glycol; the fat-soluble medicine is zedoary turmeric oil, vitamin E or coenzyme Q10, and the weight parts of the medicine are 15-45 parts; the glucose which accounts for 5 percent of the total volume is also included, and the method comprises the following steps:
step a: preparing a sodium alginate aqueous solution, a silk fibroin aqueous solution and a polyvinyl alcohol aqueous solution; step b: mixing a sodium alginate aqueous solution, a silk fibroin aqueous solution, a polyvinyl alcohol aqueous solution and glucose by using a mixing device to obtain a mixed solution A;
step c: adding poloxamer and polyethylene glycol into the mixed solution A, uniformly mixing, and finally dropwise adding a fat-soluble medicine to obtain a mixed solution B;
step d: treating with ultrasound and shearing, filtering with 450nm membrane, and sterilizing with damp heat to obtain glucose injection;
the mixing device in the step b comprises a neutralization mixing pump 11, a mixing sleeve 12 matched with the neutralization mixing pump and a third connecting pipe 13 connecting the neutralization mixing pump and the first feeding pipe, wherein the mixing sleeve is provided with four layers, and sodium alginate aqueous solution, silk fibroin aqueous solution, polyvinyl alcohol aqueous solution and glucose are sequentially supplied from outside to inside; the mixing sleeve 12 comprises a first pipe 121, a second pipe 122 arranged in the first pipe, a third pipe 123 arranged in the second pipe, a fourth pipe 124 arranged in the third pipe, a plurality of first hole sets 125 arranged on the second pipe, a plurality of second hole sets 126 arranged on the third pipe, a plurality of third hole sets 127 arranged on the fourth pipe, a first flow dividing assembly 128 arranged at the first hole set at the head end, a second flow dividing assembly 129 arranged at the second hole set at the head end, a third flow dividing assembly 130 arranged at the third hole set at the head end, a first clapboard 131 and a second clapboard 132 arranged between the first pipe and the second pipe, a third clapboard 133 arranged between the second pipe and the third pipe, a fourth clapboard 134, a fifth clapboard 135 and a sixth clapboard 136, a seventh clapboard 137, an eighth clapboard 138, a ninth clapboard 139 and a tenth clapboard 140 arranged between the third pipe and the fourth pipe, the two adjacent first hole groups are symmetrically arranged and consist of a plurality of first arc-shaped holes 141 which are distributed on the second pipe body in an annular manner at equal intervals; the sodium alginate aqueous solution between the first tube body and the second tube body enters between the second tube body and the third tube body through the first hole group at the head end by the arrangement of the first partition plate, and is mixed with the silk fibroin aqueous solution in the second tube body and the third tube body, the sodium alginate aqueous solution and the silk fibroin aqueous solution are rapidly mixed through the first shunt assembly at the head end, the sodium alginate aqueous solution and the silk fibroin aqueous solution are rapidly mixed through the second hole group at the head end after being mixed through the third partition plate, the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution are rapidly mixed through the second shunt assembly at the head end, the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution are rapidly mixed through the third hole group at the head end after being mixed through the seventh partition plate, the mixed sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution enter into the fourth tube body through the third hole group at the head end, the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution are mixed through the third shunt assembly, The silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose are quickly mixed, the mixed four materials return to a position between a fourth pipe body and a third pipe body through a third hole group adjacent to a head end third hole group, sequentially pass through a second hole group adjacent to the head end second hole group and a first hole group adjacent to the head end first hole group, sequentially enter a position between the third pipe body and the second pipe body and a position between the first pipe body and the second pipe body, the first hole group, the second hole group and the third hole group are multiple, the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose are mixed through a first partition plate to a tenth partition plate, the mixed four materials continuously return to and fro between the first pipe body and the second pipe body, between the second pipe body and the third pipe body, between the third pipe body and the fourth pipe body and in the fourth pipe body, thereby prolonging the flow length of the mixed four materials and leading the mixed four materials to have better mixing and neutralizing effect, and further mixing by a mixing pump.
As shown in fig. 1 and 7, the mixing sleeve 12 further includes a plurality of first rods 142 disposed on the second partition plate in an equidistant annular distribution and having one end fixed on the first partition plate, a plurality of second rods 143 disposed on the fourth partition plate, the fifth partition plate, and the sixth partition plate in an equidistant annular distribution and having one end fixed on the third partition plate, and a plurality of third rods 144 disposed on the eighth partition plate, the ninth partition plate, and the tenth partition plate in an equidistant annular distribution and having one end fixed on the seventh partition plate; the arrangement of the first rod body leads the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose which enter between the first pipe body and the second pipe body to be shunted, thereby having good mixing effect, the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose which enter between the second tube body and the third tube body are shunted through the arrangement of the second rod body, so that a good mixing effect is achieved, the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose which enter between the fourth tube body and the third tube body are shunted by the arrangement of the third tube body, so that a good mixing effect is achieved, the mixing efficiency and effect can be greatly improved through the flow division and mixing of the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose for many times in the flowing process, and the mixing process does not need to be stopped.
Preferably, the mass fraction of the sodium alginate aqueous solution is 0.5-2.0%, the mass fraction of the silk fibroin aqueous solution is 0.5-2%, and the mass fraction of the polyvinyl alcohol aqueous solution is 0.5-2%.
As shown in fig. 2 and 4, the first diversion assembly 128 includes a first conical plate 145, a first cavity 146 disposed in the first conical plate, a plurality of first water outlet pipes 147 annularly distributed at equal intervals on the first conical plate, a plurality of second water outlet pipes 148 penetrating the first conical plate, a first fixing ring 149 fixedly disposed on the inner wall of the second pipe body, a plurality of diversion plates 150 annularly distributed at equal intervals and fixedly disposed on the first fixing ring, and a first through hole 151 disposed in the middle of the diversion plate; the sodium alginate aqueous solution enters the first cavity in the first conical plate through the plurality of first arc-shaped holes, is discharged through the plurality of first water outlet pipes on the first cavity and then enters between the second pipe body and the third pipe body, the silk fibroin aqueous solution between the second pipe body and the third pipe body is discharged through the plurality of second water outlet pipes, the flow velocity of the sodium alginate aqueous solution discharged from the first water outlet pipe from the outside of the inner channel is sequentially increased through the arrangement of the first conical plate, the silk fibroin aqueous solution discharged from the second water outlet pipe from the outside of the inner channel is sequentially increased, the first fixing ring is arranged to mix the two to form a vortex, the mixing effect of the two is improved, the two flow to the two sides of the first fixing ring and the second fixing ring are enabled to flow through the plurality of flow distribution plates, one part of the two flow through the first through holes on the first fixing ring, and the first water outlet pipe and the second water outlet pipe are arranged in a staggered manner, so that the mixing effect of the first water outlet pipe and the second water outlet pipe can be greatly improved.
As shown in fig. 3, 5, and 6, the third shunting assembly 130 includes a rotating shaft 152 disposed at the axis of the fourth pipe, a first shaft sleeve 153 fixedly sleeved on the rotating shaft, a second shaft sleeve 154 rotatably sleeved on the rotating shaft and fixedly disposed on the inner wall of the fourth pipe, a second fixing ring 155 fixedly disposed on the inner wall of the fourth pipe, a second through hole 156 disposed at the middle of the second fixing ring, a vortex-shaped current collecting plate 157 fixedly disposed on the rotating shaft, a circular plate 158 fixedly sleeved on the rotating shaft, a plurality of inclined plates 159 equidistantly disposed on the vortex-shaped current collecting plate, a third through hole 160 disposed on the vortex-shaped current collecting plate at one end of the inclined plates, and a fourth through hole 161 disposed on the vortex-shaped current collecting plate at the other end of the inclined plates; the rotation of the rotating shaft is driven by the neutralization mixing pump, so that the vortex-shaped flow gathering plate on the rotating shaft rotates, glucose in the fourth pipe body passes through the space between the fourth pipe body and the circular plate and is mixed with the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution which enter through the third hole group, the four mixed materials flow to the middle of the vortex-shaped flow gathering plate in the rotation process of the vortex-shaped flow gathering plate and flow to the first shaft sleeve from the second through hole in the middle of the fixing ring, the four mixed materials are gathered and mixed, the flow direction of the four mixed materials can be changed by arranging the inclined plates on the four inclined plates, the four mixed materials have good mixing effect integrally, the resistance borne in the rotation process of the vortex-shaped flow gathering plate can be reduced by the third through hole and the fourth through hole, the flow speed of the four mixed materials can be improved by the third through hole and the fourth through hole, and the mixing effect at the third through hole and the fourth through hole can be improved, it is more steady to set up through first axle sleeve and second axle sleeve to make the pivot rotate the in-process, reduces and rotates rocking of in-process, improves the life of pivot, and four flow from the second through-hole to first axle sleeve direction flow after gathering through vortex form current board, shunts four again through first axle sleeve, gathers to flow promptly and assaults the mixture, shunts four again, has improved mixed effect and efficiency to four greatly.
As shown in fig. 3 and 9, the first shaft sleeve 153 includes a sleeve body 162, a first conical body 163 fixedly disposed at one end of the sleeve body, a fixing plate 164 fixed on the first conical body in an equidistant annular distribution, a driven shaft 165 rotatably disposed on the fixing plate, a second conical body 166 fixedly disposed on the driven shaft, a hollow tube 167 fixedly disposed on the driven shaft, a plurality of fifth through holes 168 and sixth through holes 169 annularly disposed on the hollow tube in an equidistant annular distribution, and a conical ring 170 fixedly disposed at one end of the hollow tube; the rotating shaft drives the first shaft sleeve to rotate in the rotating process, the sleeve body rotates, the first conical body rotates, the plurality of fixing plates on the first conical body revolve around the rotating shaft as an axis, the four mixed materials flowing through the position can flow outwards through the arrangement of the first conical body, one part of the mixed materials directly enter the hollow pipe in the flowing process and the other part of the mixed materials directly enter the hollow pipe through the fifth through hole, so that the mixed materials are impacted and mixed with the four mixed materials directly entering the hollow pipe, the mixed materials in the hollow pipe are discharged through the sixth through hole and flow through the second conical body to be shunted outwards again, and the mixed materials are arranged on the fixing plates in a rotating mode through the driven shaft, so that the hollow pipe can rotate, the four mixed materials in the hollow pipe are mixed more easily, one part of the mixed materials in the hollow pipe can flow out from other fifth through holes, and the resistance force applied in the revolution process of the hollow pipe can be reduced, the four groups can be mixed more comprehensively when flowing through the position through the revolution of the hollow pipe.
Claims (6)
1. A processing method of a glucose injection comprises a fat-soluble medicine and a capsule wall material, wherein the capsule wall material comprises the following components in parts by weight: 15-45 parts of sodium alginate, 2.5-9 parts of poloxamer, 1.5-5 parts of silk fibroin, 0.5-3 parts of polyvinyl alcohol and 0.2-3 parts of polyethylene glycol; the fat-soluble medicine is zedoary turmeric oil, vitamin E or coenzyme Q10, and the weight parts of the medicine are 15-45 parts; still include the glucose of accounting for 5% of total volume quality, its characterized in that: the method comprises the following steps:
step a: preparing a sodium alginate aqueous solution, a silk fibroin aqueous solution and a polyvinyl alcohol aqueous solution; step b: mixing a sodium alginate aqueous solution, a silk fibroin aqueous solution, a polyvinyl alcohol aqueous solution and glucose by using a mixing device to obtain a mixed solution A;
step c: adding poloxamer and polyethylene glycol into the mixed solution A, uniformly mixing, and finally dropwise adding a fat-soluble medicine to obtain a mixed solution B;
step d: treating with ultrasound and shearing, filtering with 450nm membrane, and sterilizing with damp heat to obtain glucose injection;
the mixing device in the step b comprises a neutralization mixing pump (11), a mixing sleeve (12) matched with the neutralization mixing pump and a third connecting pipe (13) connecting the neutralization mixing pump and the first feeding pipe, wherein the mixing sleeve is provided with four layers, and sodium alginate aqueous solution, silk fibroin aqueous solution, polyvinyl alcohol aqueous solution and glucose are sequentially supplied from outside to inside; the mixed sleeve (12) comprises a first pipe body (121), a second pipe body (122) arranged in the first pipe body, a third pipe body (123) arranged in the second pipe body, a fourth pipe body (124) arranged in the third pipe body, a plurality of groups of first hole groups (125) arranged on the second pipe body, a plurality of groups of second hole groups (126) arranged on the third pipe body, a plurality of groups of third hole groups (127) arranged on the fourth pipe body, a first flow distribution assembly (128) arranged at the first hole group at the head end, a second flow distribution assembly (129) arranged at the second hole group at the head end, a third flow distribution assembly (130) arranged at the third hole group at the head end, a first clapboard (131) and a second clapboard (132) arranged between the first pipe body and the second pipe body, a third clapboard (133) arranged between the second pipe body and the third pipe body, a fourth clapboard (134), a fifth clapboard (135) and a sixth clapboard (136), The first partition plate (137), the eighth partition plate (138), the ninth partition plate (139) and the tenth partition plate (140) are arranged between the third pipe body and the fourth pipe body, two adjacent groups of first hole groups are symmetrically arranged, and each first hole group consists of a plurality of first arc-shaped holes (141) which are distributed on the second pipe body in an annular mode at equal intervals; the sodium alginate aqueous solution between the first tube body and the second tube body enters between the second tube body and the third tube body through the first hole group at the head end by the arrangement of the first partition plate, and is mixed with the silk fibroin aqueous solution in the second tube body and the third tube body, the sodium alginate aqueous solution and the silk fibroin aqueous solution are rapidly mixed through the first shunt assembly at the head end, the sodium alginate aqueous solution and the silk fibroin aqueous solution are rapidly mixed through the second hole group at the head end after being mixed through the third partition plate, the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution are rapidly mixed through the second shunt assembly at the head end, the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution are rapidly mixed through the third hole group at the head end after being mixed through the seventh partition plate, the mixed sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution enter into the fourth tube body through the third hole group at the head end, the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution are mixed through the third shunt assembly, And the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose are quickly mixed, and the mixed silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose return to the position between the fourth pipe body and the third pipe body again through the third hole group adjacent to the head end third hole group, sequentially pass through the second hole group adjacent to the head end second hole group and the first hole group adjacent to the head end first hole group, and sequentially enter the position between the third pipe body and the second pipe body and the position between the first pipe body and the second pipe body.
2. The processing method of the glucose injection according to claim 1, wherein the processing method comprises the following steps: the mixing sleeve (12) also comprises a plurality of first rod bodies (142) which are distributed in an equidistant annular mode, penetrate through the second partition plate and are fixedly arranged on the first partition plate at one end, a plurality of second rod bodies (143) which are distributed in an equidistant annular mode, penetrate through the fourth partition plate, the fifth partition plate and the sixth partition plate and are fixedly arranged on the third partition plate at one end, and a plurality of third rod bodies (144) which are distributed in an equidistant annular mode, penetrate through the eighth partition plate, the ninth partition plate and the tenth partition plate and are fixedly arranged on the seventh partition plate at one end; the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose which enter between the first tube body and the second tube body are shunted through the arrangement of the first tube body, the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose which enter between the second tube body and the third tube body are shunted through the arrangement of the second tube body, and the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose which enter between the fourth tube body and the third tube body are shunted through the arrangement of the third tube body.
3. The processing method of the glucose injection according to claim 1, wherein the processing method comprises the following steps: the mass fraction of the sodium alginate aqueous solution is 0.5-2.0%, the mass fraction of the silk fibroin aqueous solution is 0.5-2%, and the mass fraction of the polyvinyl alcohol aqueous solution is 0.5-2%.
4. The processing method of the glucose injection according to claim 1, wherein the processing method comprises the following steps: the first flow distribution assembly (128) comprises a first conical plate (145), a first cavity (146) arranged in the first conical plate, a plurality of first water outlet pipes (147) which are distributed on the first conical plate in an annular mode at equal intervals, a plurality of second water outlet pipes (148) which penetrate through the first conical plate, a first fixing ring (149) which is fixedly arranged on the inner wall of the second pipe body, a plurality of flow distribution plates (150) which are distributed on the first fixing ring in an annular mode at equal intervals and fixedly arranged on the first fixing ring, and a first through hole (151) arranged in the middle of the flow distribution plates; sodium alginate aqueous solution gets into the first cavity in the first toper board through a plurality of first arc holes, just get into between second body and the third body through a plurality of first outlet pipes on the first cavity discharge, silk fibroin aqueous solution between second body and the third body is discharged from a plurality of second outlet pipes, set up through first toper board and make by interior way outer sodium alginate aqueous solution velocity of flow that follow first outlet pipe discharge increase in proper order, make by interior way outer silk fibroin aqueous solution that follow second outlet pipe discharge increase in proper order, thereby form the vortex after setting up through first solid fixed ring and making the two of this department mix, rethread a plurality of flow distribution plates make the two flow to its both sides, partly flows through first through-hole on it, mix with the two through adjacent flow distribution plate reposition of redundant personnel and touch the mixture mutually.
5. The processing method of the glucose injection according to claim 1, wherein the processing method comprises the following steps: the third shunting assembly (130) comprises a rotating shaft (152) arranged at the axis center of the fourth pipe body, a first shaft sleeve (153) fixedly sleeved on the rotating shaft, a second shaft sleeve (154) rotatably sleeved on the rotating shaft and fixedly arranged on the inner wall of the fourth pipe body, a second fixing ring (155) fixedly arranged on the inner wall of the fourth pipe body, a second through hole (156) arranged in the middle of the second fixing ring, a vortex-shaped flow collecting plate (157) fixedly arranged on the rotating shaft, a circular plate (158) fixedly sleeved on the rotating shaft, a plurality of inclined plates (159) equidistantly arranged on the vortex-shaped flow collecting plate, a third through hole (160) arranged at one end of each inclined plate on the vortex-shaped flow collecting plate, and a fourth through hole (161) arranged at the other end of each inclined plate on the vortex-shaped flow collecting plate; the vortex-shaped flow gathering plate is driven to rotate by the neutralization mixing pump, so that the vortex-shaped flow gathering plate on the rotating shaft rotates, glucose in the fourth pipe body passes through the space between the fourth pipe body and the circular plate, and the glucose and the mixture of the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution which enter through the third hole group flow towards the middle of the vortex-shaped flow gathering plate, and flow towards the first shaft sleeve from the second through hole in the middle of the fixing ring to gather and mix the four mixtures.
6. The processing method of the glucose injection according to claim 5, wherein the processing method comprises the following steps: the first shaft sleeve (153) comprises a sleeve body (162), a first conical body (163) fixedly arranged at one end of the sleeve body, a fixing plate (164) fixedly arranged on the first conical body in an equidistant annular distribution manner, a driven shaft (165) rotatably arranged on the fixing plate, a second conical body (166) fixedly arranged on the driven shaft in a fixed manner, a hollow pipe (167) fixedly arranged on the driven shaft in a fixed manner, a plurality of fifth through holes (168) and sixth through holes (169) which are annularly arranged on the hollow pipe in an equidistant manner, and a conical ring (170) fixedly arranged at one end of the hollow pipe; the rotating shaft drives the first shaft sleeve to rotate in the rotating process, the sleeve body rotates, the first conical body rotates, the fixing plates on the first conical body revolve around the rotating shaft serving as an axis, four mixed materials flowing through the first conical body can flow outwards through the first conical body, one part of the mixed materials directly enter the hollow pipe in the flowing process, one part of the mixed materials directly enter the hollow pipe through the fifth through hole, the mixed materials directly enter the hollow pipe to be mixed in an impact mode, the mixed materials in the hollow pipe are discharged through the sixth through hole and flow through the second conical body, the mixed materials are shunted outwards again, and the driven shaft rotates and is arranged on the fixing plates, so that the hollow pipe can rotate, the four mixed materials in the hollow pipe are mixed more easily, and one part of the mixed materials in the hollow pipe can flow out from other fifth through holes.
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Denomination of invention: A processing method for glucose injection Effective date of registration: 20231019 Granted publication date: 20220405 Pledgee: ZHEJIANG DONGYANG RURAL COMMERCIAL BANK Co.,Ltd. Pledgor: Zhejiang Kancheer Pharmaceutical Co.,Ltd. Registration number: Y2023980061785 |