CN112603386A - Brain tumor operation cavity interstitial fluid sampling monitoring diagnosis and treatment device - Google Patents

Brain tumor operation cavity interstitial fluid sampling monitoring diagnosis and treatment device Download PDF

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Publication number
CN112603386A
CN112603386A CN202110109858.1A CN202110109858A CN112603386A CN 112603386 A CN112603386 A CN 112603386A CN 202110109858 A CN202110109858 A CN 202110109858A CN 112603386 A CN112603386 A CN 112603386A
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bag
outer membrane
joint
interstitial fluid
reservoir
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CN112603386B (en
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步星耀
步超杰
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Henan Provincial Peoples Hospital
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Henan Provincial Peoples Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head

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  • Life Sciences & Earth Sciences (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Medical Informatics (AREA)
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Abstract

The invention designs a brain tumor operation interstitial fluid sampling monitoring diagnosis and treatment device, which comprises a liquid storage bag, wherein the liquid storage bag is connected with a flow guide pipe through a liquid storage bag connector, the end part of the flow guide pipe is communicated with a three-dimensional alternating current pump, the three-dimensional alternating current pump comprises an outer membrane bag, an elastic net and a dispersing bag, the dispersing bag is positioned at the inner side of the outer membrane bag, the elastic net is positioned between the dispersing bag and the outer membrane bag, liquid passing gaps which are uniformly distributed are longitudinally arranged on the outer membrane bag, and a plurality of liquid passing holes are formed in the outer membrane bag. The invention has the beneficial effects that: the invention has simple structure and convenient use, and the three-dimensional AC pump outer membrane capsule has larger contact surface with the tissues between the brain, so that the distribution and the collection of the treatment liquid are more extensive and comprehensive, the treatment liquid is dispersed and the impact on the brain tissues is slowed down, and the safety of the device is improved.

Description

Brain tumor operation cavity interstitial fluid sampling monitoring diagnosis and treatment device
Technical Field
The invention relates to the technical field of brain tumor in-vivo detection, monitoring, diagnosis and treatment, in particular to a brain tumor operation interstitial fluid sampling monitoring diagnosis and treatment device.
Background
Under the guidance of the concept of precise neurosurgery, the precise minimally invasive surgery not only effectively improves the brain tumor resection rate, but also effectively retains the functions of the patient, prolongs the life cycle of the patient, is beneficial to improving the postoperative life quality of the patient, provides tumor dynamic growth information, and creates opportunities for other follow-up treatments such as radiotherapy, chemotherapy, biological treatment and other auxiliary treatments. Brain tumor, especially malignant brain tumor, infiltrates and grows, and has no obvious limit with surrounding normal brain tissue, even if the most advanced operation tools and techniques are adopted to carry out precise operation at present, the tumor of important functional areas of the brain is still difficult to be completely and safely resected clinically, so the postoperative recurrence rate of patients is still high.
With the development of modern genetics research, the '2016 WHO central nervous system tumor classification' guideline adds molecular pathological content, and further promotes the accurate diagnosis and treatment of brain tumors. Although the pathological result of the current surgery or biopsy tumor tissue is the gold standard for clinical application, a reliable non-invasive specimen acquisition and detection technology is urgently needed to provide more accurate diagnosis and treatment of disease evolution and prognosis guidance for brain tumor patients due to the invasiveness of specimen acquisition after surgery and the inability to dynamically monitor the change of disease after surgery.
Since the characteristics of non-invasiveness, easy operation and the like, the imaging such as MRI and the like are always tumor diagnosis and monitoring methods widely applied clinically, but because the characteristics of the radiology are similar, the in-situ recurrence of malignant brain tumors and the change of treatment reactivity on the MRI cannot be accurately distinguished finally, and the imaging result cannot accurately guide the selection of a medication scheme. The early detection of tumor recurrence is the key to optimize individual treatment, improve prognosis and prolong overall survival, while the molecular markers after recurrence are the key to select super-adaptive target drugs, so a noninvasive and more accurate detection technology is still required to be explored to meet the clinical application requirements. Although liquid biopsy of brain tumor-derived biological samples such as blood, cerebrospinal fluid and the like is a reliable technology, accurate diagnosis of early relapse of brain tumors and monitoring of disease evolution and guidance of accurate treatment cannot be realized clinically due to anatomical position relation. Therefore, the brain tumor operation interstitial fluid sampling monitoring diagnosis and treatment device has important clinical value and wide application prospect for in-vivo biopsy and accurate diagnosis and treatment of brain tumors.
Disclosure of Invention
The invention designs a brain tumor operation interstitial fluid sampling monitoring diagnosis and treatment device, which solves the problems that the prior art can not realize non-invasive biological sample acquisition in vivo of a brain tumor patient, real-time monitoring of disease evolution and early accurate diagnosis and treatment of tumor recurrence and prognosis analysis and judgment.
The technical scheme of the invention is realized as follows:
a brain tumor operation interstitial fluid sampling monitoring diagnosis and treatment device comprises a liquid storage bag, wherein the liquid storage bag is connected with a flow guide pipe through a liquid storage bag connector, the end part of the flow guide pipe is communicated with a three-dimensional alternating current pump, the three-dimensional alternating current pump comprises an outer membrane bag, an elastic net and a dispersing bag, the dispersing bag is positioned on the inner side of the outer membrane bag, the elastic net is positioned between the dispersing bag and the outer membrane bag, liquid passing gaps which are uniformly distributed are longitudinally arranged on the outer membrane bag, a plurality of liquid passing holes are formed in the outer membrane bag, therapeutic liquid can be directly injected into the liquid storage bag, enters the three-dimensional alternating current pump through the flow guide pipe and enters brain; the brain interstitial fluid (cavity) can be directly pumped into the reservoir and then into the reservoir through the flow guide tube.
The honeycomb duct includes inner tube and outer tube, is equipped with the support blade between inner tube and the outer tube, and the support blade is arranged along honeycomb duct axis direction, prevents that the catheter from when receiving external extrusion, intraductal stifled die completely, and the reservoir connects and includes inner joint and outer joint, and the inner joint and the interior union coupling of reservoir joint, the outer joint and the outer union coupling of reservoir joint.
The tail end of the inner tube is communicated with the dispersing bag, the dispersing bag is elliptical to increase the liquid diffusion range, the dispersing bag is provided with a one-way valve I, and a one-way valve II is arranged between an inner joint and an outer joint of the liquid storage bag joint to enable liquid in the inner tube to move in one direction towards the brain and enable liquid in the outer tube to move in one direction towards the brain.
The honeycomb duct is equipped with sleeve and ear seat, and the sleeve cover is established on the honeycomb duct, is convenient for fix the honeycomb duct.
The sleeve is an L-shaped steering pipe sleeve, and the lug seat is arranged on the outer wall of the transverse pipe sleeve part of the sleeve.
The liquid storage bag is oval, and the liquid storage bag joint is located oval one end, conveniently judges the direction that the liquid storage bag connects.
The liquid storage bag is internally provided with a non-magnetic blocking sheet, so that the liquid storage bag is prevented from being punctured by a needle head during puncture.
The end part of the liquid storage bag connector is bound and connected with the flow guide pipe through a binding belt, and the end part of the liquid storage bag connector is provided with a fixing chuck to prevent the flow guide pipe from sliding down.
The surface of the outer membrane capsule is in a wrinkled shape and is similar to the outer surface of walnut kernels, so that the contact area between the outer membrane capsule and the brain tissue is effectively increased.
The invention has the beneficial effects that: the device has simple structure and convenient use, is arranged in brain tumor operation, can extract a brain interstitial (cavity) fluid biological sample participating in circulation in the liquid storage bag through extracranial head subcutaneous puncture for detection and real-time dynamic monitoring, explores the evolution and biological information change of the brain tumor, evaluates and identifies treatment reaction and effect, diagnoses relapse accurately in early stage, predicts and judges prognosis, can inject treatment fluid into intracranial through extracranial head subcutaneous liquid storage bag for individualized treatment, and obviously improves the life quality of patients and prognosis. The three-dimensional alternating-current pump outer membrane bag, the elastic net and the dispersion bag have a supporting function on brain tissue cavities and have larger contact surfaces with brain tissues, so that the biological samples distributed and collected by the treatment liquid have wider and comprehensive sources, the treatment liquid is dispersed and the impact on the brain tissues is relieved, and the safety of the device is improved; the cost is low, the sampling, monitoring and treatment can be repeatedly used, the wound and the harm to the patient can not be brought, and the clinical application and popularization prospect is wide.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is a schematic structural view of a brain tumor operation interstitial fluid sampling monitoring diagnosis and treatment device.
Figure 2 is a cross-sectional view of a reservoir.
Fig. 3 is a sectional view of the draft tube.
Fig. 4 is a schematic cross-sectional view of a type stereoscopic alternating-current pump.
Fig. 5 is a schematic view of the connection of the draft tube and the adapter.
In the figure: 1-outer membrane bag, 2-liquid passing hole, 3-elastic net, 4-outer tube, 5-one-way valve I, 6-sleeve, 7-ear seat, 8-binding band, 9-liquid storage bag joint, 10-fixing clip, 11-liquid storage bag, 12-non-magnetic separation sheet, 13-one-way valve II, 14-inner tube and 15-supporting blade.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.
Embodiment 1, as shown in fig. 1, a brain tumor operation cavity interstitial fluid sampling monitoring diagnosis and treatment device, comprising a reservoir 11, as shown in fig. 2, the reservoir 11 is oval, and a reservoir joint 9 is located at one end of the oval, so as to conveniently judge the direction of the reservoir joint, a non-magnetic separation sheet 12 is arranged in the reservoir 11, in this embodiment, the non-magnetic separation sheet 12 is a titanium sheet, so as to prevent the needle head from inserting into the reservoir 11 to absorb or inject fluid during puncture, and not penetrating the reservoir 11, the titanium sheet is non-magnetic, so as to facilitate the nuclear magnetic resonance examination of a patient, the reservoir joint 9 is arranged on the reservoir 11, the end of the reservoir joint 9 is bound and connected with a flow guide pipe through a binding belt 8, and the end of the reservoir joint 9 is provided with a fixing chuck 10 to prevent the flow guide pipe from slipping off, the end of the flow guide pipe is communicated with a stereo ac pump, the stereo ac pump comprises, the dispersion bag is located inside the outer membrane bag 1, the elastic net 3 is located between the dispersion bag and the outer membrane bag 1, the outer membrane bag 1 is vertically and evenly provided with a liquid passing gap, the outer membrane bag 1 is provided with a plurality of liquid passing holes 2, the outer membrane bag 1 plays a supporting role for the brain tissue gap, when the treatment liquid is conveyed, the dispersion bag, the elastic net 3, the outer membrane bag 1 plays a dispersing role and a buffering role, the impact of the treatment liquid on the tissues between the brains is slowed down, the treatment liquid is evenly diffused, when the interstitial liquid is extracted, the sampling range is larger and more complete, and the detection accuracy is better.
Further, as shown in fig. 1, a fixing mechanism is arranged on the flow guide pipe, the fixing mechanism comprises a sleeve 6 and an ear seat 7, the sleeve 6 is an L-shaped steering pipe sleeve, the ear seat 7 is arranged on the outer wall of the transverse pipe sleeve portion of the sleeve 6, the sleeve 6 is matched with the flow guide pipe to fix the flow guide pipe, the sleeve 6 is sleeved on the flow guide pipe, and the ear seat 7 is connected with the skull to fix the flow guide pipe.
Embodiment 2, a brain tumour art interstitial fluid sampling monitoring diagnoses ware, as shown in fig. 3, the honeycomb duct includes inner tube 14 and outer tube 4, be equipped with support blade 15 between inner tube 14 and the outer tube 4, support blade 15 and arrange along the axis direction of honeycomb duct, in this embodiment, support blade 15's quantity is 3, prevent that the catheter from receiving external pressure when extrudeing, the honeycomb duct is died totally, when the honeycomb duct received pressure, support blade 15 supports inner tube 14 and outer tube 4, the honeycomb duct can normally carry treatment fluid or extract interstitial fluid, as shown in fig. 2, fig. 5, reservoir joint 9 includes inner joint and outer joint, the inner joint and the inner tube 14 of reservoir joint 9 are connected, the outer joint and the outer tube 4 of reservoir joint 9 are connected.
Further, as shown in fig. 4, the end of the inner tube 14 is a dispersion bag, which is located inside the stereo ac pump, the dispersion bag is oval to increase the liquid diffusion area, the dispersion bag is provided with a one-way flap i 5 to make the liquid inside the dispersion bag move in one way towards the brain, a one-way flap ii 13 is arranged between the inner joint and the outer joint of the reservoir joint 9 to make the liquid inside the outer tube 4 move in one way towards the outside of the brain, the brain beats to squeeze the outer membrane bag 1, and then the liquid inside the elastic net 3 flows towards the reservoir 11 from the outer tube 4, the brain tissue contracts and loosens the outer membrane bag 1, the outer membrane bag 1 and the elastic net rebound to drive the liquid inside the reservoir 11 to flow towards the elastic net 3 from the inner tube 14, and further diffuses to the brain tissue around the. The other structure is the same as embodiment 1.
Embodiment 3, a brain tumor operation cavity interstitial fluid sampling monitoring diagnosis and treatment device, as shown in fig. 4, the three-dimensional ac pump includes an outer membrane bag 1 and an elastic net 3, the surface of the outer membrane bag 1 is corrugated and is similar to the surface shape of walnut kernel, so that the contact area between the outer membrane bag 1 and the brain tissue is large, further the coverage of the treatment fluid is wider, or the sampling range of the interstitial fluid is wide, so that the sampling is accurate, the surface of the outer membrane bag 1 is provided with liquid passing holes 2 which are arranged in a staggered manner, and the surface of the outer membrane bag 1 is provided with a plurality of longitudinal liquid passing gaps, the elastic net 3 is located inside the outer membrane bag 1, the outer membrane bag 1 plays a supporting role, the treatment fluid or the interstitial fluid can flow out or into the outer membrane bag 1 through the liquid passing holes 2 conveniently, the elastic net 3 plays a filtering role for the treatment fluid or the interstitial fluid, and the elastic net 3 can play a buffering role for the treatment fluid, so as to slow. The other structure is the same as embodiment 1.
The working principle of the invention is as follows: the brain pulsation is taken as the power of brain interstitial (cavity) fluid circulation, the brain expands to extrude the outer membrane bag 1 and the middle layer elastic net 3 of the three-dimensional alternating-current pump in the cerebrovascular contraction period, the extrusion on the outer membrane bag 1 pushes the brain interstitial (cavity) fluid to flow to the liquid storage bag 11 along the outer tube 4 of the flow guide tube, and the brain interstitial (cavity) fluid enters the liquid storage bag 11 through the outer joint of the liquid storage bag 11; in the diastole of cerebral vessels, venous blood outflow is increased, cerebral blood flow is reduced, cerebral tissue is retracted, cerebral interstitial (cavity) liquid in the dispersion bag is sucked by rebounding the outer membrane bag 1 and the elastic net 3 of the three-dimensional alternating-current pump and enters between the elastic net 3 and the dispersion bag through the opening of the one-way valve I5, the pressure of the inner dispersion bag cavity is reduced, and the cerebral interstitial (cavity) liquid in the liquid storage bag 11 flows to the dispersion bag along the inner tube 14 of the flow guide tube along the pressure difference.
When the treatment liquid is injected, the treatment liquid is injected into the liquid storage bag 11 fixed under the scalp by using an injector, the treatment liquid enters the three-dimensional alternating-current pump through the liquid guide pipe inner pipe 14, the treatment liquid enters each pathological change part through the buffer of the elastic net 3 and the liquid passing hole 2 on the outer membrane bag 1 due to the increase of the internal pressure of the three-dimensional alternating-current pump, so that residual tumor cells and tumor cells infiltrated at the periphery are killed and controlled, and the buffered treatment liquid cannot impact brain tissues.
In a normal state, interstitial fluid (cavity) in the brain enters the three-dimensional alternating-current pump through the fluid passing hole 2 and the elastic net 3, the brain expands to extrude the outer membrane bag 1 to tighten in the contraction period of the cerebral blood vessel, the interstitial fluid in the three-dimensional alternating-current pump enters the liquid storage bag 11 through the outer tube 4, the cerebral blood vessel relaxes the brain tissue to retract, the outer membrane bag 1 is loosened, the outer membrane bag 1 and the elastic net rebound, due to the pressure difference between the inner tube 14 and the outer tube 4, the interstitial fluid enters the three-dimensional alternating-current pump from the liquid storage bag 11 through the inner tube 14, the interstitial fluid circulates in the monitoring diagnosis and treatment device along with the continuous pulsation of the brain tissue, the interstitial fluid in the liquid storage bag 11 is the same as the interstitial fluid in the brain tissue, and the.
When sampling and extracting interstitial fluid, a needle head is inserted into the liquid storage bag 11, the interstitial fluid flows into the catheter outer tube 4 through the liquid holes 2 and the elastic net 3 under the action of pressure, flows into the liquid storage bag 11 along the catheter outer tube 4 and is extracted out of the body, and tumor evolution can be found and monitored in real time through biological information detection of the interstitial fluid in vitro, so that the therapeutic effect can be monitored in real time, recurrence risk can be evaluated, and an individualized therapeutic scheme can be formulated.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (9)

1. The utility model provides a brain tumour art interstitial fluid sampling monitoring diagnoses ware, including reservoir (11), reservoir (11) are connected with the honeycomb duct through reservoir joint (9), the honeycomb duct end portion communicates with three-dimensional alternating-current pump mutually, a serial communication port, three-dimensional alternating-current pump includes outer membrane bag (1), elasticity net (3) and dispersion bag, the dispersion bag is located inside outer membrane bag (1), elasticity net (3) are located between dispersion bag and outer membrane bag (1), vertically be equipped with the liquid clearance of crossing of evenly arranging on outer membrane bag (1), be equipped with a plurality of liquid holes (2) of crossing on outer membrane bag (1).
2. The brain tumor operation interstitial fluid sampling monitoring diagnosis and treatment device according to claim 1, wherein the flow guiding tube comprises an inner tube (14) and an outer tube (4), a supporting blade (15) is arranged between the inner tube (14) and the outer tube (4), the reservoir joint (9) comprises an inner joint and an outer joint, the inner joint of the reservoir joint (9) is connected with the inner tube (14), and the outer joint of the reservoir joint (9) is connected with the outer tube (4).
3. The brain tumor operation interstitial fluid sampling monitoring diagnosis and treatment device according to claim 2, wherein the end of the inner tube (14) is communicated with the dispersion bag, the dispersion bag is provided with a one-way valve I (5), and a one-way valve II (13) is arranged between the inner joint and the outer joint of the reservoir joint (9).
4. The brain tumor operation cavity interstitial fluid sampling monitoring diagnosis and treatment device according to claim 1, wherein the guide tube is provided with a sleeve (6) and an ear seat (7), and the sleeve (6) is sleeved on the guide tube.
5. The brain tumor operation interstitial fluid sampling monitoring diagnosis and treatment device according to claim 4, wherein the sleeve (6) is an L-shaped steering tube sleeve, and the ear base (7) is arranged on the outer wall of the transverse tube sleeve part of the sleeve (6).
6. The brain tumor operation interstitial fluid sampling monitoring diagnosis and treatment device according to claim 1, wherein the reservoir (11) is oval-shaped, and the reservoir joint (9) is located at one end of the oval.
7. The brain tumor operation interstitial fluid sampling monitoring diagnosis and treatment device according to claim 1, wherein a non-magnetic separation sheet (12) is arranged in the liquid storage bag (11).
8. The brain tumor operation interstitial fluid sampling monitoring diagnosis and treatment device according to claim 2, wherein the end of the reservoir connector (9) is bound with the flow guide tube through a binding band (8), and the end of the reservoir connector (9) is provided with a fixing chuck (10).
9. The brain tumor operation interstitial fluid sampling monitoring diagnosis and treatment device according to claim 1, wherein the surface of the outer membrane sac (1) is wrinkled.
CN202110109858.1A 2021-01-27 2021-01-27 Brain tumor operation cavity interstitial fluid sampling monitoring diagnosis and treatment device Active CN112603386B (en)

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Citations (11)

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Publication number Priority date Publication date Assignee Title
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US20020115942A1 (en) * 2001-02-20 2002-08-22 Stanford Ulf Harry Low profile emboli capture device
CN1514740A (en) * 2001-04-02 2004-07-21 О Conformable balloonless catheter
CN101279113A (en) * 2007-12-29 2008-10-08 孙德科 Therapeutic equipment for intracranial cystic malignancy
US20090064495A1 (en) * 2001-12-03 2009-03-12 University Of Southern California Electrochemical Fabrication Methods Incorporating Dielectric Materials and/or Using Dielectric Substrates
CN102939126A (en) * 2010-04-30 2013-02-20 雅培心脏血管***股份有限公司 Improved balloon catheter exhibiting rapid inflation and deflation
US20130158670A1 (en) * 2010-07-30 2013-06-20 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Systems and methods for cranial implant assembly adapted for insertion during craniectomy procedure
CN203539857U (en) * 2013-10-13 2014-04-16 步星耀 Three-dimensional therapentic equipment for intracranial tumour
CN205252290U (en) * 2015-12-08 2016-05-25 牟永告 Two sacculus liquid receiver
CN108653840A (en) * 2017-03-31 2018-10-16 广东省心血管病研究所 Cryptomere chamber lung auxiliary circulating equipment
CN210785938U (en) * 2019-05-05 2020-06-19 武汉大学 Intracranial tumor conformal radiotherapy and chemotherapy liquid storage bag with tumor cell collection function

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5441481A (en) * 1994-05-27 1995-08-15 Mishra; Pravin Microdialysis probes and methods of use
US20020115942A1 (en) * 2001-02-20 2002-08-22 Stanford Ulf Harry Low profile emboli capture device
CN1514740A (en) * 2001-04-02 2004-07-21 О Conformable balloonless catheter
US20090064495A1 (en) * 2001-12-03 2009-03-12 University Of Southern California Electrochemical Fabrication Methods Incorporating Dielectric Materials and/or Using Dielectric Substrates
CN101279113A (en) * 2007-12-29 2008-10-08 孙德科 Therapeutic equipment for intracranial cystic malignancy
CN102939126A (en) * 2010-04-30 2013-02-20 雅培心脏血管***股份有限公司 Improved balloon catheter exhibiting rapid inflation and deflation
US20130158670A1 (en) * 2010-07-30 2013-06-20 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Systems and methods for cranial implant assembly adapted for insertion during craniectomy procedure
CN203539857U (en) * 2013-10-13 2014-04-16 步星耀 Three-dimensional therapentic equipment for intracranial tumour
CN205252290U (en) * 2015-12-08 2016-05-25 牟永告 Two sacculus liquid receiver
CN108653840A (en) * 2017-03-31 2018-10-16 广东省心血管病研究所 Cryptomere chamber lung auxiliary circulating equipment
CN210785938U (en) * 2019-05-05 2020-06-19 武汉大学 Intracranial tumor conformal radiotherapy and chemotherapy liquid storage bag with tumor cell collection function

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