CN112603263A - Handheld photoacoustic imaging device and method - Google Patents
Handheld photoacoustic imaging device and method Download PDFInfo
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Abstract
The invention discloses a handheld photoacoustic imaging device and a method, wherein the device comprises: the device comprises a light source driving circuit, a light source array, an optical shaping system, an ultrasonic detection array, a signal amplification circuit, a signal acquisition circuit, a microprocessor ARM unit, an image display circuit, a wireless transmission circuit, a synchronous trigger circuit and a power supply. The method comprises the following steps: the photoacoustic signal is excited by the light source array and received by the ultrasonic detection array to be converted into an analog electric signal; the analog electric signal is amplified by the signal amplifying circuit, and the signal collecting circuit is converted into a digital signal and stored; the device of the invention adopts an LED/LD as an excitation light source, stores, processes and reconstructs photoacoustic signals collected by an ultrasonic detection array at an imaging device end to realize palm real-time display imaging, and simultaneously, imaging data can also be transmitted to a computer in a wireless transmission mode and displayed at the computer end.
Description
Technical Field
The invention relates to the field of photoacoustic imaging technology and device, in particular to a handheld photoacoustic imaging device and method.
Background
The photoacoustic imaging technology is a new type of bioimaging technology of non-invasive and non-ionizing type that has been rapidly developed and receives much attention in recent years. The photoacoustic imaging combines the advantages of optical imaging and ultrasonic imaging, namely the characteristics of no damage, high selectivity excitation and low attenuation and high penetrability of the optical imaging. The theory basis of photoacoustic imaging is the photoacoustic effect, when short pulse light irradiates biological tissues, an absorber in the tissues absorbs light energy, so that the temperature rises and expands to generate thermal elastic waves, the energy is emitted in the form of ultrasonic waves, and the ultrasonic signals generated by light excitation are photoacoustic signals. The photoacoustic signal generated by the biological tissue contains light absorption characteristic information of different tissue components in the tissue, and a light absorption distribution image in the tissue can be reconstructed by detecting the strength of the photoacoustic signal. The photoacoustic imaging combines the advantages of high selection characteristic in pure optical tissue imaging and deep penetration characteristic in pure ultrasonic tissue imaging, can obtain a tissue image with high resolution and high contrast, simultaneously avoids the influence of light scattering in principle, and breaks through the depth 'soft limit' (1 mm) of the traditional high-resolution optical imaging. The photoacoustic imaging can reflect the internal structure and functional information of the superficial tissues, and is a functional imaging technology for inverting physiological lesions in biological tissues based on optical absorption difference characteristics.
The traditional photoacoustic imaging adopts pulse laser as an excitation light source. For example, a solid laser (for example, Nd: YAG laser) is used as a light source device, but such a laser is generally large in size, expensive in cost, inconvenient to move, and not widely popularized in practice. Furthermore, the laser beam needs to be shaped and focused by an optical fiber, a collimator, a lens, and the like. The whole system is large, complex and difficult to operate.
Both the chinese patent CN109497952A and the CN104568758A disclose that the LED is used as an excitation source, which realizes photoacoustic imaging and reduces the volume and cost of the photoacoustic imaging system. However, the signal transmission of the above inventions is transmitted from the head ultrasonic transducer through the signal line and stored in the (external) computer, the photoacoustic imaging system connected by wire and attached with a computer or an oscilloscope is still bulky and not portable, and the connection of the signal line makes the adjustment of the detection angle and the real-time operation during imaging unfavorable.
Disclosure of Invention
The invention mainly aims to overcome the defects in the prior art, and provides a handheld photoacoustic imaging device, which realizes handheld real-time photoacoustic imaging and improves the portability and operability of the device.
Another object of the present invention is to provide a method for palm photoacoustic imaging.
In order to achieve the first purpose, the invention adopts the following technical scheme:
the invention provides a palm photoacoustic imaging device, which comprises: the device comprises a light source driving circuit, a light source array, an optical shaping system, an ultrasonic detection array, a signal amplification circuit, a signal acquisition circuit, a microprocessor ARM unit, an image display circuit, a wireless transmission circuit, a synchronous trigger circuit and a power supply; the light source driving circuit, the light source array and the optical shaping system are sequentially connected; the ultrasonic detection array, the signal amplification circuit, the signal acquisition circuit and the microprocessor ARM unit are sequentially connected; the microprocessor ARM unit is respectively connected with the image display circuit and the wireless transmission circuit; the synchronous trigger circuit is respectively connected with the light source driving circuit and the signal acquisition circuit; the power supply is respectively connected with the light source driving circuit, the synchronous trigger circuit, the signal amplification circuit, the signal acquisition circuit, the microprocessor ARM unit, the image display circuit and the wireless transmission circuit;
the light source driving circuit is used for providing driving current for the light source array and controlling pulse excitation of the light source array;
the light source array is used as an excitation light source of the photoacoustic signal to excite the imaging object to generate the photoacoustic signal;
the optical shaping system is used for shaping and focusing the scattering light spots emitted by the light source array;
the ultrasonic detection array is used for capturing photoacoustic signals excited by an imaging object and converting the photoacoustic signals into analog electric signals;
the signal amplifying circuit is used for further amplifying the analog electric signal;
the signal acquisition circuit is used for carrying out multi-path parallel analog/digital conversion and storage on the amplified analog signals;
the microprocessor ARM unit is used for processing the stored data and reconstructing an image;
the image display circuit is used for displaying the reconstructed image data under the control of the microprocessor ARM unit to form a real-time image;
the wireless transmission circuit is used for transmitting the reconstructed image to a computer with a wireless receiving function in a wireless mode;
the synchronous trigger circuit is used for providing synchronous trigger signals of the light source driving circuit and the signal acquisition circuit in parallel.
As the preferred technical scheme, the light source array is composed of a plurality of high-power single-color LEDs/LDs, the LEDs/LDs are linearly arranged, and the LEDs/LDs are connected in series; (ii) a The light source arrays are distributed on the left side and the right side of the ultrasonic detection array, and a rectangular superposed light field with the length of 24.5mm and the width of 6mm is formed by irradiation superposition.
As a preferable technical scheme, the pulse width range of the driving current in the light source driving circuit is 10ns-500ns, the pulse voltage repetition frequency range is 1KHz-6KHz, and the current magnitude range is 20A-100A.
As a preferred technical solution, the optical shaping system includes a total reflection lens and a convex lens; the light source array is positioned at the focus of the total reflection type lens; the total reflection type lens collimates the scattered light of the light source array into parallel light; the convex lens is positioned right in front of the total reflection type lens and used for focusing parallel light into linear light; the size of the light spot of the linear light is matched with the detection range of the ultrasonic detection array.
As a preferred technical solution, the ultrasonic detection array comprises a 128-array element linear array, the center frequency is 7.5MHz, and the array is located between two light source arrays; the ultrasonic detection array is positioned in the middle of the probe part, and the detection range is a rectangle with the length of 24.5mm and the width of 6 mm; the superimposed light field generated by the light source array is directly in front of the ultrasonic detection array.
As a preferred technical scheme, the signal acquisition circuit is controlled by a field programmable gate array FPGA and is used for performing analog-to-digital conversion on the multipath parallel input analog data and storing the data.
As a preferred technical scheme, the microprocessor ARM unit performs filtering and averaging processing on data by calling stored photoacoustic data, and performs image reconstruction on the data through an imaging algorithm; the microprocessor ARM unit transmits data to the LCD driver through an LCD controller in the LCD display screen; the LCD driver controls the liquid crystal molecules of each pixel point to form a final image.
As a preferred technical scheme, the wireless transmission circuit transmits the data after image reconstruction to a Wi-Fi transmitting terminal through an SPI interface; the Wi-Fi transmitting terminal is used for transmitting and uploading data to a computer.
Preferably, the power supply has a capacity of 5000mAH, a power of 42W, and a rectangular parallelepiped shape with a length of 90mm, a width of 50mm and a height of 25 mm.
In order to achieve the second object, the invention provides a handheld photoacoustic imaging method, which comprises the following steps:
(1) the imaging object is excited by pulse light emitted by the light source array, and a photoacoustic signal is excited by a thermoelastic effect;
(2) collecting photoacoustic signals generated by the imaging object through an ultrasonic detection array, and converting the photoacoustic signals into analog electric signals;
(3) further amplifying the analog electric signal output by the ultrasonic detection array through a signal amplification circuit;
(4) performing analog/digital conversion on the amplified analog signal through a signal acquisition circuit, converting an analog electric signal into a digital signal, and storing the digital signal;
(5) the stored data are subjected to data processing and image reconstruction through an ARM unit of a microprocessor to obtain photoacoustic images reflecting specific absorption of different substances in an imaged object to exciting light, and the photoacoustic images are displayed in real time through an LCD (liquid crystal display) screen;
(6) and transmitting the image data after the image reconstruction to a computer through a wireless transmission circuit.
Compared with the prior art, the invention has the following advantages and beneficial effects:
the device of the invention adopts the LED/LD as an excitation light source, stores, processes and reconstructs photoacoustic signals collected by the ultrasonic detection array at the imaging device end to realize palm real-time display imaging, and simultaneously, imaging data can be transmitted to a computer in a wireless transmission mode and displayed at the computer end. In addition, the imaging device of the invention integrates light source excitation, signal acquisition and real-time imaging, has extremely high portability and operation flexibility, can adjust the detection part in time according to the real-time imaging in the using process, and realizes the functional imaging of quick, instant and multi-position adjustment.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
Fig. 1 is an apparatus diagram of a palm photoacoustic imaging apparatus of the present invention.
Fig. 2 is a schematic front structure diagram of a palm photoacoustic imaging device according to the present invention.
Fig. 3 is a right sectional view of a palm photoacoustic imaging apparatus of the present invention.
Fig. 4 is a top view of a palm-top photoacoustic imaging apparatus of the present invention.
Fig. 5 is a system flow chart of an imaging method of a palm photoacoustic imaging device of the present invention.
Wherein 1 is an ultrasound probe array; 2-1 is the upper LED/LD light source port; 2-2 is the lower LED/LD light source port; 3-1 is an upper optical shaping system; 3-2 is a lower optical shaping system; 4-1 is an upper array of light sources; 4-2 is the lower light source array; 5-1 is an upper light source driving circuit; 5-2 is a lower light source driving circuit; 6 is an integration module; 7 is a power supply driving circuit; 8 is an image display circuit; 9 is an LCD display screen; 10 is a power supply; 11 is an acquisition switch; 12 is a power switch; and 13 is a USB charging interface.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Examples
As shown in fig. 1, fig. 2, fig. 3, and fig. 4, the handheld photoacoustic imaging device provided in this embodiment includes an ultrasonic detection array 1, an upper LED/LD light source port 2-1, a lower LED/LD light source port 2-2, an upper optical shaping system 3-1, a lower optical shaping system 3-2, an upper light source array 4-1, a lower light source array 4-2, an upper light source driving circuit 5-1, a lower light source driving circuit 5-2, an integrated module 6, a power driving circuit 7, an image display circuit 8, an LCD display screen 9, a power supply 10, an acquisition switch 11, a power supply switch 12, a USB charging port 13, and a handheld mold appearance; the integrated module 6 is integrated by a synchronous trigger circuit, a signal amplification circuit, a signal acquisition circuit, a microprocessor ARM unit and a wireless transmission circuit; all the devices and circuits are assembled and connected in the appearance of the palm mould.
As shown in fig. 3, the upper LED/LD light source port 2-1, the upper optical shaping system 3-1, the upper light source array 4-1 and the upper light source driving circuit 5-1 are connected in sequence; the lower LED/LD light source port 2-2, the lower optical shaping system 3-2, the lower light source array 4-2 and the lower light source driving circuit 5-2 are connected in sequence.
As shown in fig. 5, the ultrasonic detection array 1, the signal amplification circuit in the integrated module 6, the signal acquisition circuit in the integrated module 6, and the microprocessor ARM unit in the integrated module 6 are sequentially connected, and the microprocessor ARM unit in the integrated module 6 is respectively connected with the image display circuit 8 and the wireless transmission circuit in the integrated module 6; the synchronous trigger circuit in the integrated module 6 is respectively connected with the upper light source drive circuit 5-1, the lower light source drive circuit 5-2 and the signal acquisition circuit; the power supply 10 is connected with the power supply driving circuit 7, and the power supply driving circuit 7 is respectively connected with the upper light source driving circuit 5-1, the lower light source driving circuit 5-2, the synchronous trigger circuit in the integrated module 6, the signal amplifying circuit in the integrated module 6, the signal acquisition circuit in the integrated module 6, the microprocessor ARM unit in the integrated module 6, the wireless transmission circuit in the integrated module 6 and the image display circuit 8.
The upper light source driving circuit 5-1 is used for providing driving current for the upper light source array 4-1 and controlling the pulse excitation of the upper light source array 4-1; the lower light source driving circuit 5-2 is used for providing driving current for the lower light source array 4-2 and controlling pulse excitation of the lower light source array 4-2.
The upper light source array 4-1 and the lower light source array 4-2 are used as excitation light sources of photoacoustic signals to excite the imaging object to generate photoacoustic signals.
The upper optical shaping system 3-1 is used for shaping and focusing scattered light spots emitted by the upper light source array 4-1; the lower optical shaping system 3-2 is used for shaping and focusing the scattering light spots emitted by the lower light source array 4-2.
The upper LED/LD light source port 2-1 is used as a light outlet of the pulse light beam emitted from the upper optical shaping system 3-1 after shaping and focusing; the lower LED/LD light source port 2-2 is used as a light outlet for the shaped and focused pulse beam emitted from the lower optical shaping system 3-2.
The ultrasonic detection array 1 is used for capturing photoacoustic signals excited by an imaging object and converting the photoacoustic signals into analog electric signals.
And the synchronous trigger circuit in the integrated module 6 is used for providing synchronous trigger signals of the upper light source driving circuit 5-1, the lower light source driving circuit 5-2 and the signal acquisition circuit in the integrated module 6 in parallel.
And the signal amplification circuit in the integrated module 6 is used for further amplifying the analog electric signal output by the ultrasonic detection array 1.
And the signal acquisition circuit in the integrated module 6 is used for carrying out multi-path parallel analog/digital conversion and storage on the amplified analog signals.
And the microprocessor ARM unit in the integrated module 6 is used for processing the stored data and reconstructing an image.
And the wireless transmission circuit in the integrated module 6 is used for transmitting the reconstructed image to a computer with a wireless receiving function in a wireless mode.
The power driving circuit 7 is used for converting the electric energy provided by the power source 10 into voltage outputs with different specifications required in the system.
And the image display circuit 8 is used for displaying the reconstructed image data under the control of the microprocessor ARM unit to form a real-time image.
The LCD display screen 9 is responsible for displaying real-time images.
The power supply 10 provides the power supply of the whole handheld photoacoustic imaging device.
The acquisition switch 11 controls the excitation and acquisition of the photoacoustic signals through a synchronous trigger circuit in the integrated module 6.
The power switch 12 controls the power supply of the palm photoacoustic imaging device.
The USB charging interface 13 is used for charging the power supply 10.
Specifically, in this embodiment, the input voltage of the upper light source driving circuit 5-1 and the lower light source driving circuit 5-2 is 16V, the pulse width range of the driving current provided by the upper light source driving circuit 5-1 and the lower light source driving circuit 5-2 for the upper light source array 4-1 and the lower light source array 4-2 is 10ns-500ns, the pulse voltage repetition frequency range is 1KHz-6KHz, and the current magnitude range is 20A-100A. When the photoacoustic imaging device normally works, the driving current excites the upper light source array 4-1 and the lower light source array 4-2 to emit light, and pulse light with narrow pulse width can be obtained by utilizing the characteristic of quick response of the upper light source array 4-1 and the lower light source array 4-2, so that the photoacoustic conversion efficiency and the signal-to-noise ratio are improved; a plurality of signals can be rapidly acquired and averaged in a short time by utilizing the high pulse repetition frequency of the driving current, so that the problem of low signal-to-noise ratio caused by relatively low pulse energy of the signals is solved; when driven by pulses of high current (50A-70A), the upper light source array 4-1 and the lower light source array 4-2 can be made to provide optical output power far exceeding that of their normal continuous operation, improving their signal-to-noise ratio.
Specifically, in this embodiment, the upper light source array 4-1 and the lower light source array 4-2 adopt a plurality of high-power monochromatic LED lamps and LD lamps, the wavelength of the LED lamp is 520nm (± 10nm), the maximum input direct current is 10.5A, the wavelength of the LD lamp is 905nm, the output power is 130W, the LED lamp and the LD lamp are connected in series, the LED lamp and the LD lamp can adopt a multi-row linear array and circular array, and the upper light source array 4-1 and the lower light source array 4-2 are distributed on the upper side and the lower side of the ultrasonic detection array 1, irradiate together and are overlapped with each other to form a rectangular overlapped light field with a length of 24.5mm and a width of 6 mm.
Specifically, in the present embodiment, the upper optical shaping system 3-1 and the lower optical shaping system 3-2 each include a total reflection lens and a convex lens; the focus of the total reflection type lens of the upper light source array 4-1 and the lower light source array 4-2; the total reflection type lens refracts and reflects the passed exciting light beam and collimates the reflected exciting light beam into parallel light; the convex lens is positioned in front of the upper light source array 4-1 and the lower light source array 4-2, parallel light is focused into linear light, and the size of a light spot of the linear light is matched with the detection range of the ultrasonic detection array 1; the total reflection type lens and the convex lens are made of optical-grade PMMA materials, and the light transmittance is 93%.
Specifically, in the present embodiment, the ultrasonic detection array 1 includes an ultrasonic detection array housing, a matching layer, a piezoelectric material, a backing block, and a signal line; one end of the ultrasonic detection array for receiving/transmitting the ultrasonic is tightly connected with the ultrasonic coupler; the ultrasonic detection array 1 comprises a linear array of 128 array elements, the center frequency is 7.5MHz, and the linear array is positioned between an upper light source array 4-1 and a lower light source array 4-2; the ultrasonic detection array 1 is positioned in the middle of the probe part, and the detection range is a rectangle with the length of 24.5mm and the width of 6 mm; the superposed light fields generated by the upper light source array 4-1 and the lower light source array 4-2 are right in front of the ultrasonic detection array 1; the electric signal detected by the ultrasonic detection array 1 is transmitted to a signal amplifying circuit in the integrated module 6 through a signal wire.
Specifically, in this embodiment, the synchronous trigger circuit in the integrated module 6 is composed of a field programmable gate array FPGA, and is configured to provide a synchronous trigger signal for the upper light source driving circuit 5-1, the lower light source driving circuit 5-2, and the signal acquisition circuit in the integrated module 6; the frequency and the pulse width of the synchronous trigger signal can be set in advance in the FPGA; specifically, in the present embodiment, the frequency of the synchronous trigger signal is 5KHz, and the pulse width is 150 ns.
Specifically, in the present embodiment, the signal amplification circuit in the integrated module 6 includes a low noise amplifier and a power amplifier. The low-noise amplifier amplifies the electric signals acquired by the ultrasonic detection array 1 and simultaneously suppresses noise in the system; the power amplifier further amplifies the power of the current amplified by the low noise amplifier.
Specifically, in this embodiment, the signal acquisition circuit in the integrated module 6 performs multi-path parallel analog/digital conversion on the 128 channels of signals output by the signal amplification circuit in the integrated module 6, and stores the data in the EMMC memory.
Specifically, in this embodiment, the embedded chip used by the microprocessor ARM unit in the integrated module 6 to perform the image reconstruction process is an Exynos4412 chip of samsung corporation; the Exynos4412 chip integrates four 32-bit processor cores at 1.5GHz frequency and a GPU graphics core Mali400MP quad-core. The average power consumption for a 1.5GHz CPU full load is 0.9W. The operation memory reaches 1G, the internal storage capacity EMMC reaches 4G, the number of chip pins reaches 804, and the number of input and output pins GPIO reaches 304.
Specifically, in the present embodiment, the embedded system adopts a Linux system. The Linux system supports 32-bit hardware Linux and 64-bit hardware Linux, and is an operating system which is multitask, supports multithreading and multiple CPUs. Linux is a free open source operating system with stable system performance, can be customized and optimized to a specific embedded system, and is easy to develop and debug system software and application software.
Specifically, in this embodiment, the wireless transmission circuit in the integrated module 6 adopts an AP6181 module; the AP6181 module is a single-frequency Wi-Fi module, adopts a Botong BCM43362 scheme, has the frequency of 2.4GHz, supports an Android/Linux/RTOS operating system, provides a wireless modem function, directly utilizes sequence spread spectrum and OFDM/CCK technology, and integrates IEEE 802.11b/g/n MAC, a baseband, a radio frequency and power amplifier, a power management device, an SDIO 2.0 or SPI interface.
Specifically, in this embodiment, the microprocessor ARM unit in the integrated module 6 transmits data to the LCD driver through the LCD controller in the LCD display screen 9; the LCD driver controls the liquid crystal molecules of each pixel to form the final image in the LCD display 9.
Specifically, in this embodiment, the power supply adopts a 16V lithium battery, has a capacity of 5000mAH and a power of 42W, and is a rectangular parallelepiped with a length of 90mm, a width of 50mm and a height of 25mm, and is located in a battery box at the rear of the imaging device; when the electric quantity is insufficient, the USB charging interface 13 can be used for charging.
As shown in fig. 5, based on the above-mentioned palm photoacoustic imaging apparatus, this embodiment further provides a palm photoacoustic imaging method, which includes the following steps:
(1) closing a power switch, and supplying power by a power supply:
closing the power switch 12 of the imaging device, and starting the power supply 10 to supply the power to the upper power driving circuit 7; the power supply driving circuit 7 converts the electric energy provided by the power supply 10 into voltages of different specifications required by the ultrasonic detection array 1, the light source driving circuit 5-1, the lower light source driving circuit 5-2, the integrated module 6, the image display circuit 8 and the LCD display screen 9, and the system is initialized;
(2) closing the acquisition switch:
a synchronous trigger circuit in the integrated module 6 sends a trigger signal with a repetition frequency of pulse to the light source driving circuit 5-1 and the lower light source driving circuit 5-2; the light source driving circuit 5-1 and the lower light source driving circuit 5-2 respectively provide instantaneous heavy current with repetition frequency of 5KHz, current value of 70A and pulse width of 150ns for the upper light source array 4-1 and the lower light source array 4-2, and drive the LEDs/LDs in the upper light source array 4-1 and the lower light source array 4-2 to emit light; the light emitted from the upper light source array 4-1 and the lower light source array 4-2 respectively passes through the beam shape and the focus of the upper optical shaping system 3-1 and the lower optical shaping system 3-2, and then is emitted from the upper LED/LD light source port 2-1 and the lower LED/LD light source port 2-2; the emergent light beams are converged right in front of the ultrasonic detection array 1 at the head of the palm photoacoustic imaging device.
(3) Collecting photoacoustic signals:
coating a small amount of ultrasonic coupling liquid on the surface of an imaging object, and attaching the ultrasonic coupling liquid to the front of the ultrasonic detection array 1 at the head of the palm photoacoustic imaging device; a synchronous trigger circuit in the integrated module 6 sends a synchronous trigger signal to a signal acquisition circuit in the integrated module 6, wherein the synchronous trigger signal controls 128 channels in the signal acquisition circuit to acquire and receive photoacoustic signals excited by pulsed light; photoacoustic signals excited by the upper light source array 4-1 and the lower light source array 4-2 are collected by the ultrasonic detection array 1, and the photoacoustic signals are converted into analog electric signals;
(4) signal amplification:
the signal amplification circuit in the integrated module 6 further amplifies the weak analog electric signal generated by the ultrasonic detection array 1: a low-noise amplifier in the signal amplification circuit amplifies an analog electric signal and simultaneously suppresses noise; the power amplifier in the signal amplification circuit further performs power amplification on the analog electric signal amplified by the low-noise amplifier;
(5) signal A/D conversion:
the analog electrical signal amplified by the signal amplifying circuit in the integrated module 6 is subjected to analog/digital conversion by the signal acquisition circuit in the integrated module 6, the analog electrical signal is converted into a digital electrical signal, and the digital electrical signal is stored;
(6) image reconstruction and real-time display:
the microprocessor ARM unit in the integrated module 6 performs data analysis, processing and image reconstruction on the stored digital electric signal data to obtain photoacoustic images reflecting specific absorption of different substances in an imaged object to exciting light, and the photoacoustic images are displayed in real time through an LCD (liquid crystal display) screen 9; the reconstructed image data can also be transmitted to an external computer through a wireless transmission circuit in the integrated module 6.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (10)
1. A handheld photoacoustic imaging device, comprising: the device comprises a light source driving circuit, a light source array, an optical shaping system, an ultrasonic detection array, a signal amplification circuit, a signal acquisition circuit, a microprocessor ARM unit, an image display circuit, a wireless transmission circuit, a synchronous trigger circuit and a power supply; the light source driving circuit, the light source array and the optical shaping system are sequentially connected; the ultrasonic detection array, the signal amplification circuit, the signal acquisition circuit and the microprocessor ARM unit are sequentially connected; the microprocessor ARM unit is respectively connected with the image display circuit and the wireless transmission circuit; the synchronous trigger circuit is respectively connected with the light source driving circuit and the signal acquisition circuit; the power supply is respectively connected with the light source driving circuit, the synchronous trigger circuit, the signal amplification circuit, the signal acquisition circuit, the microprocessor ARM unit, the image display circuit and the wireless transmission circuit;
the light source driving circuit is used for providing driving current for the light source array and controlling pulse excitation of the light source array;
the light source array is used as an excitation light source of the photoacoustic signal to excite the imaging object to generate the photoacoustic signal;
the optical shaping system is used for shaping and focusing the scattering light spots emitted by the light source array;
the ultrasonic detection array is used for capturing photoacoustic signals excited by an imaging object and converting the photoacoustic signals into analog electric signals;
the signal amplifying circuit is used for further amplifying the analog electric signal;
the signal acquisition circuit is used for carrying out multi-path parallel analog/digital conversion and storage on the amplified analog signals;
the microprocessor ARM unit is used for processing the stored data and reconstructing an image;
the image display circuit is used for displaying the reconstructed image data under the control of the microprocessor ARM unit to form a real-time image;
the wireless transmission circuit is used for transmitting the reconstructed image to a computer with a wireless receiving function in a wireless mode;
the synchronous trigger circuit is used for providing synchronous trigger signals of the light source driving circuit and the signal acquisition circuit in parallel.
2. The palm photoacoustic imaging device of claim 1, wherein the light source array is composed of a plurality of high-power single-color LEDs/LDs, the LEDs/LDs are arranged linearly, and the LEDs/LDs are connected in series; the light source arrays are distributed on two sides of the ultrasonic detection array, and the light source arrays irradiate and overlap to form a rectangular overlapped light field with the length of 24.5mm and the width of 6 mm.
3. The palm photoacoustic imaging device of claim 1, wherein the pulse width of the driving current in the light source driving circuit is in the range of 10ns to 500ns, the pulse voltage repetition frequency is in the range of 1KHz to 6KHz, and the current magnitude is in the range of 20A to 100A.
4. The palm photoacoustic imaging device of claim 1, wherein the optical shaping system comprises a total reflection lens and a convex lens; the light source array is positioned at the focus of the total reflection type lens; the total reflection type lens collimates the scattered light of the light source array into parallel light; the convex lens is positioned right in front of the total reflection type lens and used for focusing parallel light into linear light; the size of the light spot of the linear light is matched with the detection range of the ultrasonic detection array.
5. The palm photoacoustic imaging device of claim 1, wherein the ultrasound probe array comprises a linear array of 128 elements centered at 7.5MHz between two arrays of light sources; the ultrasonic detection array is positioned in the middle of the probe part, and the detection range is a rectangle with the length of 24.5mm and the width of 6 mm; the superimposed light field generated by the light source array is directly in front of the ultrasonic detection array.
6. The palm photoacoustic imaging device according to claim 1, wherein the signal acquisition circuit is controlled by a Field Programmable Gate Array (FPGA) and is used for performing analog-to-digital conversion on the multiple paths of analog data input in parallel and storing the data.
7. The palm photoacoustic imaging device according to claim 1, wherein the microprocessor ARM unit filters and averages the stored photoacoustic data by calling the photoacoustic data, and reconstructs an image of the data by an imaging algorithm; the microprocessor ARM unit transmits data to the LCD driver through an LCD controller in the LCD display screen; the LCD driver controls the liquid crystal molecules of each pixel point to form a final image.
8. The palm photoacoustic imaging device according to claim 1, wherein the wireless transmission circuit transmits the data after image reconstruction to the Wi-Fi transmitting terminal through the SPI interface; the Wi-Fi transmitting terminal is used for transmitting and uploading data to a computer.
9. A hand-held photoacoustic imaging device as claimed in claim 1, wherein said power source has a capacity of 5000mAH and a power of 42W and is in the shape of a rectangular parallelepiped 90mm long, 50mm wide and 25mm high.
10. A method of palm photoacoustic imaging based on the device of any of claims 1-9, comprising the steps of:
the imaging object is excited by pulse light emitted by the light source array, and a photoacoustic signal is excited by a thermoelastic effect;
collecting photoacoustic signals generated by the imaging object through an ultrasonic detection array, and converting the photoacoustic signals into analog electric signals;
further amplifying the analog electric signal output by the ultrasonic detection array through a signal amplification circuit;
performing analog/digital conversion on the amplified analog signal through a signal acquisition circuit, converting an analog electric signal into a digital signal, and storing the digital signal;
the stored data are subjected to data processing and image reconstruction through an ARM unit of a microprocessor to obtain photoacoustic images reflecting specific absorption of different substances in an imaged object to exciting light, and the photoacoustic images are displayed in real time through an LCD (liquid crystal display) screen;
and transmitting the image data after the image reconstruction to a computer through a wireless transmission circuit.
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