CN112587714A - Absorbable wire capable of promoting skin collagen synthesis and using method thereof - Google Patents
Absorbable wire capable of promoting skin collagen synthesis and using method thereof Download PDFInfo
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- CN112587714A CN112587714A CN202011499990.XA CN202011499990A CN112587714A CN 112587714 A CN112587714 A CN 112587714A CN 202011499990 A CN202011499990 A CN 202011499990A CN 112587714 A CN112587714 A CN 112587714A
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- Prior art keywords
- skin
- absorbable
- collagen synthesis
- polycaprolactone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/105—Polyesters not covered by A61L17/12
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
- A61L17/145—Coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses an absorbable wire for promoting skin collagen synthesis and a using method thereof, wherein a double-helix polycaprolactone absorbable suture is made of semi-crystalline linear polyester, is directly prepared from a monomer e-caprolactone through ring-opening polymerization, has a relative molecular weight of 40000, takes D & C violet No. 2 as a dye, is sterilized by ethylene oxide after being prepared, and is filled into a 27G-60MM type stainless steel needle tube. Compared with the prior art, the invention has the advantages that: overcomes the defects of large wound, high risk, long recovery period, permanent scar and the like of the traditional wrinkle-removing operation; and has no practical effect on thinning, atrophy and elasticity reduction of skin; the common photoelectric instrument treatment has the defects of inaccurate effect and short maintenance time; provides a novel safe non-invasive non-recovery period-free non-operative comprehensive treatment method with definite and lasting effect.
Description
Technical Field
The invention relates to the field of medical supplies, in particular to an absorbable wire for promoting skin collagen synthesis and a using method thereof.
Background
High concentration of auto-active factors is a biologically active biological medium from autologous venous serum that regulates cell growth. They release a variety of cytokines substantially from platelet alpha particles during variable speed centrifugation, mainly including: TGF-. beta.s (transforming growth factor-. beta.), PDGF (platelet-derived growth factor), VEGF (vascular endothelial growth factor), IGF (insulin-like growth factor), EGF (epidermal growth factor), FGF (fibroblast growth factor), and the like. They have the functions of promoting the repair, regeneration, immunoregulation and the like of skin collagen and blood vessels. There is no medical consumable that can be used effectively.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a suture capable of promoting the repair and regeneration of skin and blood vessels and a using method thereof.
In order to solve the technical problems, the technical scheme provided by the invention is as follows: an absorbable suture of double-spiral polycaprolactone is prepared from semi-crystalline linear polyester, and E-caprolactone through ring-opening polymerization, relative molecular weight of 40000, using D & C violet No. 2 as dye, sterilizing with ethylene oxide, and loading in 27G-60MM stainless steel needle tube.
As an improvement, the using method comprises the following steps:
(1) tightening and supporting: embedding the double-helix polycaprolactone absorbable suture into the bottom layer of the aged skin in a crisscross manner, tightening and supporting the skin immediately and stimulating the regeneration of collagen;
(2) and (3) separating active factors: extracting 20-30 ml of autoblood, and preparing high-concentration auto-active factors by a low-temperature variable-speed centrifuge
(3) Intradermal introduction: guiding the prepared high-concentration active factors into the skin layer through the micro-needle;
(4) deep water locking: injecting non-crosslinked modified sodium hyaluronate into skin layer.
As an improvement, the explanation cycle of the double-helix polycaprolactone absorbable suture is 2-3 years.
As an improvement, the double-helix polycaprolactone absorbable suture.
As an improvement, the non-crosslinked modified sodium hyaluronate for injection consists of a pre-filled glass syringe and a gel particle suspension encapsulated in the syringe.
Compared with the prior art, the invention has the advantages that: overcomes the defects of large wound, high risk, long recovery period, permanent scar and the like of the traditional wrinkle-removing operation; and has no practical effect on thinning, atrophy and elasticity reduction of skin; the common photoelectric instrument treatment has the defects of inaccurate effect and short maintenance time; provides a novel safe non-invasive non-recovery period-free non-operative comprehensive treatment method with definite and lasting effect.
Detailed Description
The present invention is described in further detail below.
In the specific implementation of the invention, the double-helix polycaprolactone absorbable suture is made of semi-crystalline linear polyester, is prepared by directly ring-opening polymerizing a monomer e-caprolactone, has a relative molecular weight of 40000 and takes D & C Violet No. 2 as a dye, and is filled into a 27G-60MM stainless steel needle tube after being sterilized by ethylene oxide after the preparation.
As an improvement, the using method comprises the following steps:
(1) tightening and supporting: embedding the double-helix polycaprolactone absorbable suture into the bottom layer of the aged skin in a crisscross manner, tightening and supporting the skin immediately and stimulating the regeneration of collagen;
(2) and (3) separating active factors: extracting 20-30 ml of autoblood, and preparing high-concentration auto-active factors by a low-temperature variable-speed centrifuge
(3) Intradermal introduction: guiding the prepared high-concentration active factors into the skin layer through the micro-needle;
(4) deep water locking: injecting non-crosslinked modified sodium hyaluronate into skin layer.
As an improvement, the explanation cycle of the double-helix polycaprolactone absorbable suture is 2-3 years.
As an improvement, the double-helix polycaprolactone absorbable suture.
As an improvement, the non-crosslinked modified sodium hyaluronate for injection consists of a pre-filled glass syringe and a gel particle suspension encapsulated in the syringe.
The working principle of the invention is as follows: the double-helix polycaprolactone absorbable suture is semi-crystalline linear polyester and is prepared by directly carrying out ring-opening polymerization on a monomer e-caprolactone. The molecular weight is 40000, the copolymer is easily dissolved in a plurality of organic solvents and can be copolymerized with a plurality of macromolecules; the degradation period is 2-3 years, the material is softer, the biocompatibility is good, and the biodegradable material can be used for medium and long-term biodegradable materials and has no toxic reaction when being implanted under the skin. The structure of the thread body is multi-strand weaving, the coating adopts calcium stearate, the suture thread is dyed by D & C violet No. 2, and the suture thread is arranged in a 27G-60MM type stainless steel needle tube. Disposable product, ethylene oxide sterilization.
Non-crosslinked modified sodium hyaluronate for injection the product consists of a pre-filled glass syringe and a gel particle suspension encapsulated in the syringe. The gel particle suspension consists of uncrosslinked sodium hyaluronate, lidocaine hydrochloride, sodium chloride, a phosphate buffer system and water for injection, wherein the sodium hyaluronate is prepared by a microbial fermentation method and has the marked concentration of 23 mg/mL. The syringe encapsulating the gel particle suspension has been moist heat sterilized.
The cryostatic variable speed centrifuge is a Medifuge200 centrifugal system technology manufactured by Safton, Italy. The method utilizes physical acceleration and deceleration, adopts differential uninterrupted centrifugation technology, fully activates alpha particles in platelets in the centrifugation process, generates cell active factors with higher concentration and high purity, and does not need to add chemical substances such as activating agents.
The high-concentration self-activity factor, the low-temperature variable-speed centrifuge, the double-helix polycaprolactone absorbable suture line and the non-crosslinked modified sodium hyaluronate for injection are used, and a non-surgical technology is combined, so that the aging symptoms of skin relaxation, atrophy, wrinkles and elasticity reduction are safely and effectively improved, the firmness, the thickness and the elasticity of the skin are improved, the whole youthful effect is generated, and the restoration is improved.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature, and in the description of the invention, "plurality" means two or more unless explicitly specifically defined otherwise.
In the present invention, unless otherwise specifically stated or limited, the terms "mounted," "connected," "fixed," and the like are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly above and obliquely above the second feature, or simply meaning that the first feature is at a lesser level than the second feature.
In the description herein, reference to the terms "one embodiment," "some embodiments," "an example," "a specific example," or "some examples" or the like means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made in the above embodiments by those of ordinary skill in the art without departing from the principle and spirit of the present invention.
Claims (5)
1. An absorbable wire for promoting skin collagen synthesis and a using method thereof are characterized in that: the double-helix polycaprolactone absorbable suture is made of semi-crystalline linear polyester, is formed by directly carrying out ring-opening polymerization on a monomer e-caprolactone, has a relative molecular weight of 40000, takes D & C Violet No. 2 as a dye, and is filled into a 27G-60MM type stainless steel needle tube after being sterilized by ethylene oxide after the preparation is finished.
2. An absorbable wire for promoting skin collagen synthesis and method of use thereof, according to claim 1, wherein the method of use is:
(1) tightening and supporting: embedding the double-helix polycaprolactone absorbable suture into the bottom layer of the aged skin in a crisscross manner, tightening and supporting the skin immediately and stimulating the regeneration of collagen;
(2) and (3) separating active factors: extracting 20-30 ml of autoblood, and preparing high-concentration auto-active factors by a low-temperature variable-speed centrifuge
(3) Intradermal introduction: guiding the prepared high-concentration active factors into the skin layer through the micro-needle;
(4) deep water locking: injecting non-crosslinked modified sodium hyaluronate into skin layer.
3. An absorbable wire for promoting collagen synthesis in skin and method of use thereof, as claimed in claim 1, wherein: the explanation cycle of the double-helix polycaprolactone absorbable suture is 2-3 years.
4. An absorbable wire for promoting collagen synthesis in skin and method of use thereof, as claimed in claim 1, wherein: the double-helix polycaprolactone absorbable suture.
5. An absorbable wire for promoting collagen synthesis in skin and method of use thereof, as claimed in claim 2, wherein: the non-crosslinked modified sodium hyaluronate for injection consists of a pre-filled and sealed glass syringe and gel particle suspension packaged in the syringe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011499990.XA CN112587714A (en) | 2020-12-18 | 2020-12-18 | Absorbable wire capable of promoting skin collagen synthesis and using method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011499990.XA CN112587714A (en) | 2020-12-18 | 2020-12-18 | Absorbable wire capable of promoting skin collagen synthesis and using method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112587714A true CN112587714A (en) | 2021-04-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011499990.XA Pending CN112587714A (en) | 2020-12-18 | 2020-12-18 | Absorbable wire capable of promoting skin collagen synthesis and using method thereof |
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| CN (1) | CN112587714A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103747746A (en) * | 2010-11-03 | 2014-04-23 | 伊西康有限责任公司 | Drug-eluting self-retaining sutures and methods relating thereto |
| CN106267341A (en) * | 2016-08-30 | 2017-01-04 | 圆容生物医药无锡有限公司 | One can organize induction bio-medical material |
| CN107096065A (en) * | 2017-04-05 | 2017-08-29 | 浙江大学 | Composite nano-fiber membrane containing polysialic acids and preparation method and application |
| CN109575247A (en) * | 2018-11-21 | 2019-04-05 | 华东理工大学 | A method of polycaprolactone porous material is prepared based on non-aqueous High Internal Phase Emulsion |
| CN112316198A (en) * | 2020-11-13 | 2021-02-05 | 浙江桐轩医疗科技有限公司 | Absorbable and degradable suture line |
-
2020
- 2020-12-18 CN CN202011499990.XA patent/CN112587714A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103747746A (en) * | 2010-11-03 | 2014-04-23 | 伊西康有限责任公司 | Drug-eluting self-retaining sutures and methods relating thereto |
| CN106267341A (en) * | 2016-08-30 | 2017-01-04 | 圆容生物医药无锡有限公司 | One can organize induction bio-medical material |
| CN107096065A (en) * | 2017-04-05 | 2017-08-29 | 浙江大学 | Composite nano-fiber membrane containing polysialic acids and preparation method and application |
| CN109575247A (en) * | 2018-11-21 | 2019-04-05 | 华东理工大学 | A method of polycaprolactone porous material is prepared based on non-aqueous High Internal Phase Emulsion |
| CN112316198A (en) * | 2020-11-13 | 2021-02-05 | 浙江桐轩医疗科技有限公司 | Absorbable and degradable suture line |
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Application publication date: 20210402 |