CN112569457A - Continuous drug delivery bag tube system - Google Patents
Continuous drug delivery bag tube system Download PDFInfo
- Publication number
- CN112569457A CN112569457A CN202011451940.4A CN202011451940A CN112569457A CN 112569457 A CN112569457 A CN 112569457A CN 202011451940 A CN202011451940 A CN 202011451940A CN 112569457 A CN112569457 A CN 112569457A
- Authority
- CN
- China
- Prior art keywords
- saccular
- cecum
- sac
- drainage tube
- flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000012377 drug delivery Methods 0.000 title claims abstract description 18
- 239000003814 drug Substances 0.000 claims abstract description 48
- 210000004534 cecum Anatomy 0.000 claims abstract description 35
- 239000012530 fluid Substances 0.000 claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 8
- 230000010412 perfusion Effects 0.000 claims abstract description 6
- 229940079593 drug Drugs 0.000 claims description 19
- 238000002347 injection Methods 0.000 claims description 11
- 239000007924 injection Substances 0.000 claims description 11
- 239000002775 capsule Substances 0.000 claims description 8
- 238000010255 intramuscular injection Methods 0.000 claims description 8
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 238000010253 intravenous injection Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 238000010254 subcutaneous injection Methods 0.000 claims description 5
- 238000001990 intravenous administration Methods 0.000 claims description 4
- 230000002459 sustained effect Effects 0.000 claims description 3
- 210000003717 douglas' pouch Anatomy 0.000 claims 4
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 7
- 239000000741 silica gel Substances 0.000 description 7
- 229910002027 silica gel Inorganic materials 0.000 description 7
- 230000000694 effects Effects 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 239000007927 intramuscular injection Substances 0.000 description 3
- 238000011200 topical administration Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention relates to a continuous drug delivery sac tube system, which comprises a sac-shaped blind end, a current-limiting channel and a drainage tube, wherein the sac-shaped blind end is made of an elastic expandable material and can be buried under the skin; the flow-limiting channel is hermetically connected between the saccular blind end and the drainage tube; the saccular blind end is used for storing the fluid medicine and continuously perfusing the fluid medicine to a treatment target through the flow limiting channel and the drainage tube; the flow restricting passage is used for limiting the flow rate and the flow rate of the fluid medicine flowing out of the saccular cecum, so that the fluid medicine injected into the saccular cecum is temporarily reserved in the saccular cecum, and then the saccular cecum is expanded, thereby maintaining the continuous perfusion of the fluid medicine from the saccular cecum to the open end of the drainage tube.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a continuous drug delivery capsule tube system.
Background
At present, the traditional administration mode of chemotherapeutic drugs is mainly intravenous injection, and the method cannot accurately kill tumors, so the method has the defects of low efficiency, large side effect and the like. Topical administration is a preferred improvement to solve the above problems, and comprises: disposable medicine local injection, multiple puncture local administration and the like, local medicine injection through a drainage tube and the like. However, the above-mentioned topical administration methods all have their own drawbacks, which limit their clinical application.
Disadvantages of various topical administration methods include: the disposable medicine local injection has limited space in the body, so the total administration dosage is low and the action time is short; the local drug delivery through multiple puncture needs CT assistance and higher technical level, and the risk is higher, so the popularization is difficult; the local injection of the medicine through the drainage tube easily causes bacteria in vitro to enter the body through the outer opening of the drainage tube, and has great risk of deep infection. Therefore, the development of new topical drug delivery devices to avoid the above disadvantages has significant clinical implications.
Disclosure of Invention
The invention aims to provide a novel continuous drug delivery capsule tube system, which solves the problems of small drug loading, short action time, high puncture operation risk, easy deep infection and the like of a local drug delivery scheme in the prior art.
The invention aims to solve the defects of the prior art and provides a novel continuous drug delivery sac tube system which comprises a sac-like blind end, a current-limiting channel and a drainage tube, wherein the sac-like blind end is made of an elastic expandable material and can be buried under the skin; the flow limiting channel is hermetically connected between the saccular blind end and the drainage tube; the saccular blind end is used for storing fluid medicines and continuously perfusing the fluid medicines to a treatment target through the flow limiting channel and the drainage tube; the flow-restricting passage is used for limiting the flow rate and the flow quantity of the fluid medicine flowing out of the saccular cecum, so that the fluid medicine injected into the saccular cecum is temporarily reserved in the saccular cecum, and then the saccular cecum is expanded, and the continuous perfusion of the fluid medicine from the saccular cecum to the open end of the drainage tube is maintained.
The therapeutic target comprises the position around the tumor or around the infection focus in the human body.
The open end of the drainage tube is implanted into a treatment target spot at the deep part of a human body.
After the saccular cecum is buried under the skin, the medicine is injected into the saccular cecum buried under the skin through a simple subcutaneous, intramuscular or intravenous injection technology.
Preferably, the saccular cecum allows the injection of a drug into the saccular cecum buried under the skin using a common intramuscular injection needle, a hypodermic needle or an intravenous infusion needle.
One or more than one saccular blind end is arranged.
One or more open ends are arranged.
The saccular blind end, the flow-limiting channel and the drainage tube are made of elastic silica gel.
The saccular cecum can store 10ml to 400ml of medicine.
The restricted flow channel allows a restricted flow rate of fluid medication out of the sac-like dead end of 0.5 ml/day to 10 ml/day with an average administration period of 1 week to 1 year.
Advantageous effects
Compared with the prior art, the invention has the beneficial effects that:
according to the sustained drug delivery sac tube system, one end of a traditional silica gel drainage tube is made into an expanded sac-shaped blind end and is used for being embedded under the skin to store drugs and receive in-vitro drug injection, and in the application process, the sac-shaped blind end embedded under the skin can contain more drugs, so that the problem of small drug loading rate in one-time drug local injection is solved; the continuous drug delivery capsule tube system can be used for repeated drug delivery, and the flow limiting channel can maintain continuous perfusion of the drug, so that the problem of short action time of local injection of the disposable drug is avoided; when the continuous drug delivery capsule tube system is used, the puncture operation for local drug delivery is similar to the conventional subcutaneous, intramuscular or intravenous injection operation, and CT assistance is not needed, so that the problems of high puncture operation difficulty and high risk caused by multiple times of puncture and local drug delivery are avoided; the saccular cecum of the continuous drug delivery saccular tube system is buried under the skin, and has no external part, so that the risk of deep infection caused by external bacteria entering the body through the external opening of the drainage tube is reduced.
Drawings
The accompanying drawings are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention.
FIG. 1 is a schematic view of the overall structure of a sustained-delivery capsule system according to the present invention.
Detailed Description
The present invention is described in more detail below to facilitate an understanding of the present invention.
As shown in figure 1, the continuous drug delivery sac tube system comprises a sac-like blind end 1, a flow limiting channel 2 and a drainage tube 3, wherein the sac-like blind end is made of an elastic expandable material and can be buried under the skin; the flow limiting channel 2 is hermetically connected between the saccular blind end 1 and the drainage tube 3; the saccular blind end is used for storing fluid medicine and continuously perfusing the fluid medicine to a treatment target through the flow limiting channel 2 and the drainage tube 3; the flow restricting passage 2 is used for limiting the flow rate and the flow rate of the fluid medicine flowing out from the saccular cecum, so that the fluid medicine injected into the saccular cecum is temporarily reserved in the saccular cecum, and then the saccular cecum is expanded, thereby maintaining the continuous perfusion of the fluid medicine from the saccular cecum to the open end 4 of the drainage tube.
The therapeutic target comprises the position around the tumor or around the infection focus in the human body.
The open end of the drainage tube is implanted into a treatment target spot at the deep part of a human body.
After the saccular cecum is buried under the skin, the medicine is injected into the saccular cecum buried under the skin through a simple subcutaneous, intramuscular or intravenous injection technology.
Preferably, the saccular cecum allows the injection of a drug into the saccular cecum buried under the skin using a common intramuscular injection needle, a hypodermic needle or an intravenous infusion needle.
Further preferably, the bladder-like blind end is provided with one or more than one, and the open end is also provided with one or more than one, so as to realize the loading and delivery of one or more than one medicament.
The saccular blind end, the flow-limiting channel and the drainage tube are made of elastic silica gel.
The continuous drug administration sac tube system is improved on the basis of the traditional silica gel drainage tube, only the internal part of the traditional drainage tube is reserved, one end of the shallow part of the drainage tube is made into an inflatable sac-shaped dead end by elastic silica gel, a narrow flow limiting channel is reserved between the sac-shaped dead end and the drainage tube, and the flow limiting channel only allows liquid to slowly flow through (the sac-shaped dead end stores medicine about 10-400ml, the flow limiting channel limits the flow rate to 0.5-10 ml/day, and the average drug administration period is about 1 week-1 year) so as to temporarily retain the medicine injected into the inflatable dead end and further expand the sac-shaped dead end, thereby maintaining the continuous perfusion of the medicine from the dead end to the open end. The user can implant the open end of the invention into a deep treatment target (such as around a tumor or around an infected focus) according to the implantation mode of a traditional drainage tube, and then embed the saccular blind end of the invention under the skin. After operation, the common intramuscular injection needle, the hypodermic needle or the intravenous infusion needle is used, and the simple subcutaneous, intramuscular or intravenous injection technology is adopted, so that the medicine can be injected into the saccular cecum buried under the skin; the medicine injected into the saccular cecum can enter a deep treatment target through the drainage tube, so that the effect of accurate treatment is achieved.
The materials of the saccular blind end, the flow-limiting channel and the drainage tube are not limited to silica gel materials, and other materials which can be used for human body implantation can be used as substitute materials of silica gel.
The foregoing describes preferred embodiments of the present invention, but is not intended to limit the invention thereto. Modifications and variations of the embodiments disclosed herein may be made by those skilled in the art without departing from the scope and spirit of the invention.
Claims (10)
1. The continuous drug delivery sac tube system is characterized by comprising a sac-shaped blind end, a flow limiting channel and a drainage tube, wherein the sac-shaped blind end is made of an elastic expandable material and can be buried under the skin; the flow limiting channel is hermetically connected between the saccular blind end and the drainage tube; the saccular blind end is used for storing fluid medicines and continuously perfusing the fluid medicines to a treatment target through the flow limiting channel and the drainage tube; the flow-restricting passage is used for limiting the flow rate and the flow quantity of the fluid medicine flowing out of the saccular cecum, so that the fluid medicine injected into the saccular cecum is temporarily reserved in the saccular cecum, and then the saccular cecum is expanded, and the continuous perfusion of the fluid medicine from the saccular cecum to the open end of the drainage tube is maintained.
2. The continuous delivery balloon catheter system of claim 1, wherein the target of treatment comprises a site in the body surrounding a tumor or a lesion of infection.
3. The continuous delivery balloon catheter system of claim 1, wherein the open end of the drainage tube is implanted at a target site of treatment deep in the body.
4. The sustained delivery balloon catheter system according to claim 1, wherein the balloon-like cul-de-sac allows injection of the drug into the balloon-like cul-de-sac subcutaneously by a simple subcutaneous, intramuscular or intravenous injection technique after the balloon-like cul-de-sac has been subcutaneously implanted.
5. The continuous delivery balloon catheter system of claim 4, wherein the balloon-like cecum allows for injection of the drug into the balloon-like cecum buried under the skin using a common intramuscular, subcutaneous or intravenous needle.
6. The continuous delivery capsule system of claim 1, wherein said capsule cecum is provided with one or more.
7. The continuous delivery capsule system of claim 1, wherein said open end is provided with one or more.
8. The continuous delivery bladder system of claim 1 wherein the bladder culm, the flow restriction passage and the drainage tube are formed of elastomeric silicone.
9. The sustained delivery balloon catheter system of claim 1 wherein the balloon-like blind end is capable of holding between 10ml and 400ml of drug.
10. The continuous delivery bladder system of claim 1 wherein said restricted flow passage provides a restricted flow rate of fluid drug out of said bladder cul-de-sac of from 0.5 ml/day to 10 ml/day for an average delivery period of from 1 week to 1 year.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011451940.4A CN112569457B (en) | 2020-12-10 | 2020-12-10 | Continuous administration cyst tube system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011451940.4A CN112569457B (en) | 2020-12-10 | 2020-12-10 | Continuous administration cyst tube system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112569457A true CN112569457A (en) | 2021-03-30 |
| CN112569457B CN112569457B (en) | 2024-02-13 |
Family
ID=75131229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011451940.4A Active CN112569457B (en) | 2020-12-10 | 2020-12-10 | Continuous administration cyst tube system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112569457B (en) |
Citations (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1130743A (en) * | 1956-08-30 | 1957-02-11 | Flexible containers | |
| US3796217A (en) * | 1972-03-10 | 1974-03-12 | Hydr Med Sciences Inc | Drug release system |
| US5688237A (en) * | 1995-05-04 | 1997-11-18 | Cedars-Sinai Medical Center | Implantable catheter and method of use |
| US5773019A (en) * | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
| CN2362514Y (en) * | 1998-11-03 | 2000-02-09 | 陈军 | Embedding type medicine introducing device |
| US20030014036A1 (en) * | 2001-06-12 | 2003-01-16 | Varner Signe Erickson | Reservoir device for intraocular drug delivery |
| US20030078550A1 (en) * | 2001-10-22 | 2003-04-24 | Williamson Shobha Devi | Implantable pump catheter access port denial device |
| US20030171401A1 (en) * | 1999-03-18 | 2003-09-11 | Johnson Randolph Mellus | Devices and methods for pain management |
| US20050107753A1 (en) * | 2002-02-01 | 2005-05-19 | Ali Rezai | Microinfusion device |
| CN2712349Y (en) * | 2004-07-12 | 2005-07-27 | 郑士全 | Subcutaneous implantable sustained-release silica gel rod for antipsychotics |
| CN1787844A (en) * | 2003-05-29 | 2006-06-14 | 瑞尼斯豪公司 | Implantable pump |
| CN200998518Y (en) * | 2006-11-03 | 2008-01-02 | 刘爱军 | Micro-wound implanting type radiotherapy bursa |
| CN101224315A (en) * | 2007-12-28 | 2008-07-23 | 李楠 | Infusion method of multiple medicine and velocity and device thereof |
| US20090149838A1 (en) * | 2007-12-10 | 2009-06-11 | Cassada David C | Subcutaneous Implant System |
| WO2009125181A1 (en) * | 2008-04-08 | 2009-10-15 | Epsom And St Helier University Hospitals Nhs Trust | Subcutaneous port and catheter |
| US20110208122A1 (en) * | 2010-02-22 | 2011-08-25 | Avraham Shekalim | Slow release liquid drug delivery device |
| US20150025478A1 (en) * | 2005-04-27 | 2015-01-22 | C. R. Bard, Inc. | Reinforced Septum for an Implantable Medical Device |
| CN104857622A (en) * | 2015-06-10 | 2015-08-26 | 徐增良 | Drainage tube |
| CN106470731A (en) * | 2014-03-27 | 2017-03-01 | 贝塔O2技术有限公司 | Implantable medical device |
| US20170095653A1 (en) * | 2015-10-06 | 2017-04-06 | The Johns Hopkins University | Universal microport |
| CN107735142A (en) * | 2015-04-07 | 2018-02-23 | 伊哈卜·萨阿卜 | Implanted fluid delivery system |
| CN107753418A (en) * | 2017-11-20 | 2018-03-06 | 中国农业科学院北京畜牧兽医研究所 | Medicament slow release implants and heeling-in device |
| CN108042899A (en) * | 2018-01-24 | 2018-05-18 | 山东百多安医疗器械有限公司 | A kind of dual valve implantable drug delivery system |
| CN110841134A (en) * | 2018-08-20 | 2020-02-28 | 张海军 | Automatic drug delivery system for treating Parkinson's disease |
| KR20200032023A (en) * | 2019-12-06 | 2020-03-25 | 주식회사 유니메딕스 | Patient controlled drug administration device |
| CN214633242U (en) * | 2020-12-10 | 2021-11-09 | 北京大学第三医院（北京大学第三临床医学院） | Fully-implanted deep continuous administration silicone capsule tube system |
-
2020
- 2020-12-10 CN CN202011451940.4A patent/CN112569457B/en active Active
Patent Citations (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1130743A (en) * | 1956-08-30 | 1957-02-11 | Flexible containers | |
| US3796217A (en) * | 1972-03-10 | 1974-03-12 | Hydr Med Sciences Inc | Drug release system |
| US5688237A (en) * | 1995-05-04 | 1997-11-18 | Cedars-Sinai Medical Center | Implantable catheter and method of use |
| US5773019A (en) * | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
| CN2362514Y (en) * | 1998-11-03 | 2000-02-09 | 陈军 | Embedding type medicine introducing device |
| US20030171401A1 (en) * | 1999-03-18 | 2003-09-11 | Johnson Randolph Mellus | Devices and methods for pain management |
| US20030014036A1 (en) * | 2001-06-12 | 2003-01-16 | Varner Signe Erickson | Reservoir device for intraocular drug delivery |
| US20030078550A1 (en) * | 2001-10-22 | 2003-04-24 | Williamson Shobha Devi | Implantable pump catheter access port denial device |
| US20050107753A1 (en) * | 2002-02-01 | 2005-05-19 | Ali Rezai | Microinfusion device |
| CN1787844A (en) * | 2003-05-29 | 2006-06-14 | 瑞尼斯豪公司 | Implantable pump |
| CN2712349Y (en) * | 2004-07-12 | 2005-07-27 | 郑士全 | Subcutaneous implantable sustained-release silica gel rod for antipsychotics |
| US20150025478A1 (en) * | 2005-04-27 | 2015-01-22 | C. R. Bard, Inc. | Reinforced Septum for an Implantable Medical Device |
| CN200998518Y (en) * | 2006-11-03 | 2008-01-02 | 刘爱军 | Micro-wound implanting type radiotherapy bursa |
| US20090149838A1 (en) * | 2007-12-10 | 2009-06-11 | Cassada David C | Subcutaneous Implant System |
| CN101224315A (en) * | 2007-12-28 | 2008-07-23 | 李楠 | Infusion method of multiple medicine and velocity and device thereof |
| WO2009125181A1 (en) * | 2008-04-08 | 2009-10-15 | Epsom And St Helier University Hospitals Nhs Trust | Subcutaneous port and catheter |
| US20110208122A1 (en) * | 2010-02-22 | 2011-08-25 | Avraham Shekalim | Slow release liquid drug delivery device |
| CN106470731A (en) * | 2014-03-27 | 2017-03-01 | 贝塔O2技术有限公司 | Implantable medical device |
| CN107735142A (en) * | 2015-04-07 | 2018-02-23 | 伊哈卜·萨阿卜 | Implanted fluid delivery system |
| CN104857622A (en) * | 2015-06-10 | 2015-08-26 | 徐增良 | Drainage tube |
| US20170095653A1 (en) * | 2015-10-06 | 2017-04-06 | The Johns Hopkins University | Universal microport |
| CN107753418A (en) * | 2017-11-20 | 2018-03-06 | 中国农业科学院北京畜牧兽医研究所 | Medicament slow release implants and heeling-in device |
| CN108042899A (en) * | 2018-01-24 | 2018-05-18 | 山东百多安医疗器械有限公司 | A kind of dual valve implantable drug delivery system |
| CN110841134A (en) * | 2018-08-20 | 2020-02-28 | 张海军 | Automatic drug delivery system for treating Parkinson's disease |
| KR20200032023A (en) * | 2019-12-06 | 2020-03-25 | 주식회사 유니메딕스 | Patient controlled drug administration device |
| CN214633242U (en) * | 2020-12-10 | 2021-11-09 | 北京大学第三医院（北京大学第三临床医学院） | Fully-implanted deep continuous administration silicone capsule tube system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112569457B (en) | 2024-02-13 |
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